Christopher Moody

Works (6)

Updated: April 5th, 2024 11:40

2023 journal article

Loading Intracranial Drug-Eluting Reservoirs Across the Blood-Brain Barrier With Focused Ultrasound


By: C. Moody n, P. Durham n, P. Dayton n & Y. Brudno n

author keywords: Blood-brain barrier; Brain delivery; Click chemistry; Drug delivery; Focused ultrasound
MeSH headings : Female; Mice; Animals; Blood-Brain Barrier; Drug Delivery Systems / methods; Neurodegenerative Diseases; Brain / diagnostic imaging; Microbubbles; Magnetic Resonance Imaging / methods
Sources: Web Of Science, ORCID
Added: June 19, 2023

2022 journal article

Restoring Carboxylates on Highly Modified Alginates Improves Gelation, Tissue Retention and Systemic Capture


By: C. Moody n, A. Brown n, N. Massaro n, A. Patel n, P. Agarwalla n, A. Simpson n, A. Brown n, H. Zheng n, J. Pierce n, Y. Brudno n

author keywords: Alginate; Click chemistry; Bioconjugation; Ionic cross-linking; Drug capture
Sources: Web Of Science, ORCID
Added: October 31, 2021

2021 journal article

On-Demand Drug Release from Click-Refillable Drug Depots


By: S. Palvai n, C. Moody n, S. Pandit n & Y. Brudno n

author keywords: drug delivery; bioorthogonal; stimuli-responsive; photocleavage; click chemistry
MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacokinetics; Cell Line, Tumor; Click Chemistry / methods; Delayed-Action Preparations; Doxorubicin / administration & dosage; Doxorubicin / pharmacokinetics; Drug Delivery Systems / methods; Drug Liberation; Fluorescent Dyes; Humans; Mice
Sources: Web Of Science, ORCID
Added: October 26, 2021

2020 journal article

In Vivo Targeting Using Arylboronate/Nopoldiol Click Conjugation

BIOCONJUGATE CHEMISTRY, 31(10), 2288–2292.

By: S. Palvai n, J. Bhangu*, B. Akgun*, C. Moody n, D. Hall* & Y. Brudno n

co-author countries: Canada 🇨🇦
MeSH headings : Animals; Boronic Acids / chemical synthesis; Boronic Acids / chemistry; Click Chemistry / methods; Crystallography, X-Ray; Magnetic Resonance Spectroscopy; Mice; Models, Molecular; Semicarbazides / chemical synthesis; Semicarbazides / chemistry
Sources: Web Of Science, ORCID
Added: December 21, 2020

2019 journal article

Extracellular-Matrix-Anchored Click Motifs for Specific Tissue Targeting

Molecular Pharmaceutics, 17(2), 392–403.

By: M. Adams n, C. Moody n, J. Sollinger n & Y. Brudno n

author keywords: drug delivery; click chemistry; pancreatic cancer; brain delivery; extracellular matrix; computer modeling
MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacokinetics; Brain / metabolism; Cell Line, Tumor; Click Chemistry / methods; Computational Biology / methods; Computer Simulation; Disease Models, Animal; Drug Delivery Systems / methods; Esters / administration & dosage; Esters / chemistry; Esters / pharmacokinetics; Extracellular Matrix / drug effects; Female; Hydrogels / administration & dosage; Mice; Mice, Inbred C57BL; Pancreatic Neoplasms / drug therapy; Pancreatic Neoplasms / pathology; Succinimides; Tissue Distribution
Sources: Web Of Science, ORCID, Crossref
Added: April 20, 2020

2018 journal article

Replenishable drug depot to combat post-resection cancer recurrence

BIOMATERIALS, 178, 373–382.

By: Y. Brudno n, M. Pezone, T. Snyder, O. Uzun, C. Moody n, M. Aizenberg, D. Mooney*

author keywords: Biomaterials; Drug delivery; Cancer therapy; Drug depot; Sustained release
MeSH headings : Alginates / chemistry; Animals; Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Antineoplastic Agents / therapeutic use; Cell Line, Tumor; Cell Proliferation / drug effects; Click Chemistry; Doxorubicin / chemistry; Doxorubicin / pharmacology; Doxorubicin / therapeutic use; Female; Hydrogels / chemistry; Kinetics; Mice; Neoplasm Recurrence, Local / drug therapy; Neoplasm Recurrence, Local / pathology; Neoplasms / pathology; Neoplasms / surgery; Prodrugs / chemical synthesis; Prodrugs / pharmacology; Prodrugs / therapeutic use; Prodrugs / toxicity; Subcutaneous Tissue / drug effects
Sources: Web Of Science, ORCID
Added: October 19, 2018

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