Christopher Moody

Works (6)

Updated: April 5th, 2024 11:40

2023 article

Loading Intracranial Drug-Eluting Reservoirs Across the Blood–Brain Barrier With Focused Ultrasound

Moody, C. T., Durham, P. G., Dayton, P. A., & Brudno, Y. (2023, April 27). Ultrasound in Medicine & Biology, Vol. 49, pp. 1679–1685.

By: C. Moody n, P. Durham  n, P. Dayton n & Y. Brudno n 

author keywords: Blood-brain barrier; Brain delivery; Click chemistry; Drug delivery; Focused ultrasound
MeSH headings : Female; Mice; Animals; Blood-Brain Barrier; Drug Delivery Systems / methods; Neurodegenerative Diseases; Brain / diagnostic imaging; Microbubbles; Magnetic Resonance Imaging / methods
topics (OpenAlex): Ultrasound and Hyperthermia Applications; Photoacoustic and Ultrasonic Imaging; Nanoplatforms for cancer theranostics
TL;DR: The ability to target and retain small molecules at predetermined intracranial sites with pinpoint accuracy provides opportunities to continuously deliver drugs to the brain over weeks and months without excessive BBB opening and with minimal off-target side effects. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 19, 2023

2021 article

On-Demand Drug Release from Click-Refillable Drug Depots

Palvai, S., Moody, C. T., Pandit, S., & Brudno, Y. (2021, September 8). Molecular Pharmaceutics, Vol. 18, pp. 3920–3925.

By: S. Palvai n, C. Moody n, S. Pandit n & Y. Brudno n 

author keywords: drug delivery; bioorthogonal; stimuli-responsive; photocleavage; click chemistry
MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacokinetics; Cell Line, Tumor; Click Chemistry / methods; Delayed-Action Preparations; Doxorubicin / administration & dosage; Doxorubicin / pharmacokinetics; Drug Delivery Systems / methods; Drug Liberation; Fluorescent Dyes; Humans; Mice
topics (OpenAlex): Click Chemistry and Applications; Peptidase Inhibition and Analysis; Nanoplatforms for cancer theranostics
TL;DR: An on- demand drug delivery paradigm that combines bioorthogonal click chemistry to locally enrich protodrugs at a prelabeled site and light-triggered drug release at the target tissue is reported, establishing a novel method for in vivo targeting and on-demand delivery of cytotoxic drugs at target tissues. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 26, 2021

2021 journal article

Restoring Carboxylates on Highly Modified Alginates Improves Gelation, Tissue Retention and Systemic Capture

Acta Biomaterialia, 138, 208–217.

By: C. Moody n, A. Brown n , N. Massaro n, A. Patel n, P. Agarwalla n, A. Simpson  n, A. Brown, H. Zheng n , J. Pierce n , Y. Brudno n 

author keywords: Alginate; Click chemistry; Bioconjugation; Ionic cross-linking; Drug capture
MeSH headings : Alginates; Cell Adhesion; Hydrogels; Injections; Tissue Engineering
topics (OpenAlex): 3D Printing in Biomedical Research; Hydrogels: synthesis, properties, applications; Tissue Engineering and Regenerative Medicine
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: October 31, 2021

2020 article

In Vivo Targeting Using Arylboronate/Nopoldiol Click Conjugation

Palvai, S., Bhangu, J., Akgun, B., Moody, C. T., Hall, D. G., & Brudno, Y. (2020, September 22). Bioconjugate Chemistry, Vol. 31, pp. 2288–2292.

By: S. Palvai n, J. Bhangu*, B. Akgun*, C. Moody n, D. Hall * & Y. Brudno n 

MeSH headings : Animals; Boronic Acids / chemical synthesis; Boronic Acids / chemistry; Click Chemistry / methods; Crystallography, X-Ray; Magnetic Resonance Spectroscopy; Mice; Models, Molecular; Semicarbazides / chemical synthesis; Semicarbazides / chemistry
topics (OpenAlex): Click Chemistry and Applications; Chemical Synthesis and Analysis; Advanced Biosensing Techniques and Applications
TL;DR: A detailed structural analysis of the arylboronate/nopoldiol adduct is reported that the bioorthogonal reactants form, unexpectedly, a tetracyclic adduct through the cyclization of the distal nitrogen into the semithiocarbazone leading to a strong B-N dative bond and two new 5-membered rings. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 21, 2020

2019 journal article

Extracellular-Matrix-Anchored Click Motifs for Specific Tissue Targeting

Molecular Pharmaceutics, 12(2), 392–403.

By: M. Adams n, C. Moody n, J. Sollinger n & Y. Brudno n 

author keywords: drug delivery; click chemistry; pancreatic cancer; brain delivery; extracellular matrix; computer modeling
MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacokinetics; Brain / metabolism; Cell Line, Tumor; Click Chemistry / methods; Computational Biology / methods; Computer Simulation; Disease Models, Animal; Drug Delivery Systems / methods; Esters / administration & dosage; Esters / chemistry; Esters / pharmacokinetics; Extracellular Matrix / drug effects; Female; Hydrogels / administration & dosage; Mice; Mice, Inbred C57BL; Pancreatic Neoplasms / drug therapy; Pancreatic Neoplasms / pathology; Succinimides; Tissue Distribution
topics (OpenAlex): Nanoplatforms for cancer theranostics; RNA Interference and Gene Delivery; Cancer Research and Treatments
TL;DR: ECM-anchored click groups do not elicit any noticeable local or systemic toxicity or immune response and specifically capture systemically-circulating molecules at intradermal, intratumoral, and intracranial sites for multiple months. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: April 20, 2020

2018 article

Replenishable drug depot to combat post-resection cancer recurrence

Brudno, Y., Pezone, M. J., Snyder, T. K., Uzun, O., Moody, C. T., Aizenberg, M., & Mooney, D. J. (2018, May 6). Biomaterials, Vol. 178, pp. 373–382.

By: Y. Brudno n , M. Pezone, T. Snyder, O. Uzun, C. Moody n, M. Aizenberg, D. Mooney *

author keywords: Biomaterials; Drug delivery; Cancer therapy; Drug depot; Sustained release
MeSH headings : Alginates / chemistry; Animals; Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Antineoplastic Agents / therapeutic use; Cell Line, Tumor; Cell Proliferation / drug effects; Click Chemistry; Doxorubicin / chemistry; Doxorubicin / pharmacology; Doxorubicin / therapeutic use; Female; Hydrogels / chemistry; Kinetics; Mice; Neoplasm Recurrence, Local / drug therapy; Neoplasm Recurrence, Local / pathology; Neoplasms / pathology; Neoplasms / surgery; Prodrugs / chemical synthesis; Prodrugs / pharmacology; Prodrugs / therapeutic use; Prodrugs / toxicity; Subcutaneous Tissue / drug effects
topics (OpenAlex): Nanoplatforms for cancer theranostics; Click Chemistry and Applications; Advanced biosensing and bioanalysis techniques
TL;DR: A refillable hydrogel depot system based on bioorthogonal click chemistry that captures prodrug refills from the blood and subsequently releases active drugs locally in a sustained manner to improve cancer therapy while eliminating systemic side effects is presented. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 19, 2018

Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.

Certain data included herein are derived from the Web of Science© and InCites© (2026) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.