Chris Thomas Smith

Works (30)

Updated: August 3rd, 2023 17:20

2022 article

The U.S. academic job market survives the SARS-CoV-2 global pandemic

Kozik, A. J., Hagan, A., Jadavji, N. M., Smith, C. T., & Haage, A. (2022, May 30).

By: A. Kozik *, A. Hagan *, N. Jadavji *, C. Smith*  & A. Haage *

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: June 5, 2022

2022 article

The faculty-to-faculty mentorship experience: a survey on challenges and recommendations for improvements

Sarabipour, S., Burgess, S. J., Niemi, N. M., Smith, C. T., Filho, A. W. B., Ibrahim, A., & Clark, K. (2022, October 19).

By: S. Sarabipour *, S. Burgess *, N. Niemi, C. Smith* , A. Filho *, A. Ibrahim *, K. Clark *

Source: ORCID
Added: October 20, 2022

2021 article

Dopamine biases sensitivity to personal goals and social influence in self-control over everyday desires

Castrellon, J. J., Young, J. S., Dang, L. C., Smith, C. T., Cowan, R. L., Zald, D. H., & Samanez-Larkin, G. R. (2021, September 11). (Vol. 9). Vol. 9.

By: J. Castrellon *, J. Young *, L. Dang *, C. Smith* , R. Cowan *, D. Zald *, G. Samanez-Larkin *

TL;DR: Findings provide unique evidence that the dopamine system influences decision making and regulatory behavior and provides new insights into how these mechanisms interact with personal goals and social contexts. (via Semantic Scholar)
UN Sustainable Development Goal Categories
16. Peace, Justice and Strong Institutions (OpenAlex)
Source: ORCID
Added: September 13, 2021

2021 journal article

Reproducibility of findings in modern PET neuroimaging: insight from the NRM2018 grand challenge

Journal of Cerebral Blood Flow & Metabolism, 5, 0271678X2110151.

Chris Smith

author keywords: PET; data analysis; data sharing; reproducibility crisis; "NRM2018 PET Grand Challenge"
MeSH headings : Congresses as Topic; Female; History, 21st Century; Humans; Male; Neuroimaging / methods; Positron-Emission Tomography / methods; Reproducibility of Results
TL;DR: This paper investigates the issue of reproducibility of findings in brain PET imaging and finds that during the 2018 NeuroReceptor Mapping conference, the brain PET community was challenged with a computational contest involving a simulated neurotransmitter release experiment, with consistent solutions. (via Semantic Scholar)
Source: ORCID
Added: May 21, 2021

2020 journal article

A survey-based analysis of the academic job market

ELife, 9.

By: J. Fernandes *, S. Sarabipour *, C. Smith n , N. Niemi *, N. Jadavji *, A. Kozik *, A. Holehouse *, V. Pejaver * ...

MeSH headings : Achievement; Career Mobility; Faculty / statistics & numerical data; Female; Humans; Job Application; Knowledge; Male; Publishing; Research; Research Personnel / statistics & numerical data; Surveys and Questionnaires; Universities
UN Sustainable Development Goal Categories
4. Quality Education (Web of Science)
Source: ORCID
Added: June 14, 2020

2019 journal article

Differential regional decline in dopamine receptor availability across adulthood: Linear and nonlinear effects of age

Human Brain Mapping, 4.

By: K. Seaman *, C. Smith* , E. Juarez *, L. Dang *, J. Castrellon *, L. Burgess*, M. Juan*, P. Kundzicz* ...

author keywords: aging; D2 receptors; dopamine; positron emission tomography imaging; regional differences
MeSH headings : Adult; Aged; Aged, 80 and over; Aging / metabolism; Brain / metabolism; Cross-Sectional Studies; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Models, Statistical; Positron-Emission Tomography; Receptors, Dopamine D2 / metabolism; Receptors, Dopamine D3 / metabolism; Young Adult
TL;DR: Overall, these data indicate that the rate and pattern of decline in D2 receptor availability is regionally heterogeneous, and existing theories of adult brain development may need to be modified to better account for the spatial dynamics of dopaminergic system aging. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: December 4, 2019

2019 journal article

Individual Differences in Dopamine Are Associated with Reward Discounting in Clinical Groups But Not in Healthy Adults

The Journal of Neuroscience, 39(2), 321–332.

By: J. Castrellon, K. Seaman *, J. Crawford *, J. Young *, C. Smith* , L. Dang *, M. Hsu *, R. Cowan *, D. Zald *, G. Samanez-Larkin *

author keywords: decision making; delay discounting; dopamine; effort; PET; probability
MeSH headings : Adolescent; Adult; Aged; Aged, 80 and over; Aging / psychology; Behavior, Addictive / diagnostic imaging; Behavior, Addictive / psychology; Brain / diagnostic imaging; Brain / physiology; Brain Mapping; Delay Discounting; Dopamine / metabolism; Female; Humans; Individuality; Male; Mental Disorders / diagnostic imaging; Mental Disorders / psychology; Middle Aged; Positron-Emission Tomography; Receptors, Dopamine D2 / genetics; Receptors, Dopamine D2 / metabolism; Reward; Young Adult
TL;DR: It is shown that individual differences in DA D2 receptor availability are not consistently related to monetary discounting of time, probability, or physical effort in healthy individuals across a broad age range, and suggested that psychopathology accounts for observed inconsistencies in the relationship between measures of DA function and reward discounting behavior. (via Semantic Scholar)
Source: ORCID
Added: December 4, 2019

2019 article

Insights from a survey-based analysis of the academic job market

Fernandes, J. D., Sarabipour, S., Smith, C. T., Niemi, N. M., Jadavji, N. M., Kozik, A. J., … Haage, A. (2019, October 9). (Vol. 10). Vol. 10.

By: J. Fernandes *, S. Sarabipour *, C. Smith n , N. Niemi *, N. Jadavji *, A. Kozik *, A. Holehouse *, V. Pejaver * ...

TL;DR: There is no single clear path to a faculty job offer and metrics such as career transition awards and publications in high impact factor journals were neither necessary nor sufficient for landing a faculty position, suggesting the need to improve the transparency of the faculty job application process. (via Semantic Scholar)
Source: ORCID
Added: December 4, 2019

2019 journal article

Lack of consistent sex differences in d-amphetamine-induced dopamine release measured with [18F]fallypride PET

Psychopharmacology, 236(2), 581–590.

By: C. Smith* , L. Dang *, L. Burgess*, S. Perkins*, M. Juan*, D. Smith*, R. Cowan *, N. Le* ...

author keywords: (up to 10): Sex differences; Dopamine; PET; D2/3 receptor availability; Dopamine release; d-amphetamine
MeSH headings : Adult; Aged; Benzamides; Central Nervous System Stimulants / pharmacology; Dextroamphetamine / pharmacology; Dopamine / metabolism; Female; Fluorine Radioisotopes; Humans; Male; Middle Aged; Positron-Emission Tomography; Receptors, Dopamine D2 / drug effects; Receptors, Dopamine D2 / metabolism; Receptors, Dopamine D3 / drug effects; Receptors, Dopamine D3 / metabolism; Sex Characteristics; Sex Factors; Ventral Striatum / diagnostic imaging; Ventral Striatum / drug effects; Ventral Striatum / metabolism; Young Adult
TL;DR: There was limited evidence for greater right ventral striatal dopamine release in young adult males relative to similarly aged females, but this was not consistently observed across samples and the data do not support the presence of consistent widespread sex differences in this measure of dopamine release. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: December 4, 2019

2019 journal article

Partial-volume correction increases estimated dopamine D2-like receptor binding potential and reduces adult age differences

Journal of Cerebral Blood Flow & Metabolism, 39(5), 822–833.

By: C. Smith* , J. Crawford *, L. Dang *, K. Seaman *, M. Juan*, A. Vijay *, D. Katz*, D. Matuskey * ...

author keywords: Aging; D2 receptors; dopamine; partial volume correction; positron emission tomography imaging
MeSH headings : Adult; Aged; Aging; Brain / physiology; Dopamine / metabolism; Female; Gray Matter / physiology; Humans; Male; Middle Aged; Positron-Emission Tomography / methods; Protein Binding; Receptors, Dopamine D2 / metabolism
TL;DR: It is suggested that PVC increases estimated BPND in general and reduces adult age differences especially when using lower resolution cameras, and the past 30 years of research on dopamine receptor availability, for which very few studies use PVC, may overestimate effects of aging on dopamine receptors availability. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: December 4, 2019

2019 journal article

Reproducibility of the correlative triad among aging, dopamine receptor availability, and cognition.

Psychology and Aging, 34(7), 921–932.

By: E. Juarez, J. Castrellon, M. Green, J. Crawford, K. Seaman, C. Smith* , L. Dang, D. Matuskey ...

author keywords: cognition; working memory; aging; dopamine; PET
MeSH headings : Adult; Aged; Aged, 80 and over; Aging / physiology; Animals; Cognition / physiology; Cross-Sectional Studies; Female; Healthy Volunteers; Humans; Male; Middle Aged; Receptors, Dopamine D2 / metabolism; Reproducibility of Results; Young Adult
UN Sustainable Development Goal Categories
Sources: Crossref, Web Of Science, NC State University Libraries, ORCID
Added: November 25, 2019

2018 article

Differential regional decline in dopamine receptor availability across adulthood: Linear and nonlinear effects of age

Seaman, K. L., Smith, C. T., Juarez, E. J., Dang, L. C., Castrellon, J. J., Burgess, L. L., … Samanez-Larkin, G. R. (2018, June 29). (Vol. 6). Vol. 6.

By: K. Seaman *, C. Smith* , E. Juarez *, L. Dang *, J. Castrellon *, L. Burgess, M. Juan*, P. Kundzicz * ...

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: December 4, 2019

2018 journal article

FTO affects food cravings and interacts with age to influence age-related decline in food cravings

Physiology and Behavior, 192, 188–193.

By: L. Dang *, G. Samanez-Larkin*, C. Smith* , J. Castrellon *, S. Perkins*, R. Cowan *, D. Claassen *, D. Zald *

Contributors: L. Dang *, G. Samanez-Larkin*, C. Smith* , J. Castrellon *, S. Perkins*, R. Cowan *, D. Claassen *, D. Zald *

author keywords: FTO; Food cravings; Aging; Dopamine receptor availability
MeSH headings : Adult; Aged; Aged, 80 and over; Aging / genetics; Aging / psychology; Alpha-Ketoglutarate-Dependent Dioxygenase FTO / genetics; Benzamides; Body Mass Index; Brain / diagnostic imaging; Brain / metabolism; Craving / physiology; Feeding Behavior / physiology; Feeding Behavior / psychology; Female; Food; Genetic Association Studies; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Positron-Emission Tomography; Pyrrolidines; Radiopharmaceuticals; Receptors, Dopamine D2 / metabolism; Young Adult
TL;DR: Testing whether FTO is associated with differences in food cravings and a key aspect of dopamine function that has been hypothesized to influence food reward mechanisms found no evidence of FTO effects on DRD2 availability. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: ORCID
Added: December 4, 2019

2018 article

Individual differences in dopamine are associated with reward discounting in clinical groups but not in healthy adults

Castrellon, J. J., Seaman, K. L., Crawford, J. L., Young, J. S., Smith, C. T., Dang, L. C., … Samanez-Larkin, G. R. (2018, August 2). (Vol. 8). Vol. 8.

By: J. Castrellon, K. Seaman, J. Crawford, J. Young, C. Smith* , L. Dang, M. Hsu, R. Cowan, D. Zald, G. Samanez-Larkin

Source: ORCID
Added: December 4, 2019

2018 journal article

Nigrostriatal and mesolimbic D<inf>2/3</inf>receptor expression in Parkinson’s disease patients with compulsive reward-driven behaviors

Journal of Neuroscience, 38(13), 3230–3239.

By: A. Stark *, C. Smith* , Y. Lin *, K. Petersen *, P. Trujillo *, N. Van Wouwe *, X. Kang *, M. Donahue * ...

Contributors: A. Stark *, C. Smith* , Y. Lin *, K. Petersen *, P. Trujillo *, N. Van Wouwe *, X. Kang *, M. Donahue * ...

author keywords: dopamine; impulse control disorder; impulsive compulsive behaviors; mesocorticolimbic; Parkinson's disease; positron emission tomography
MeSH headings : Aged; Benzamides; Compulsive Behavior / diagnostic imaging; Compulsive Behavior / etiology; Compulsive Behavior / metabolism; Dopamine Agonists / pharmacology; Dopamine D2 Receptor Antagonists / pharmacology; Female; Humans; Limbic System / diagnostic imaging; Limbic System / drug effects; Limbic System / metabolism; Male; Middle Aged; Parkinson Disease / complications; Parkinson Disease / diagnostic imaging; Parkinson Disease / metabolism; Positron-Emission Tomography; Radiopharmaceuticals; Receptors, Dopamine D2 / metabolism; Receptors, Dopamine D3 / metabolism; Reward; Substantia Nigra / diagnostic imaging; Substantia Nigra / drug effects; Substantia Nigra / metabolism
TL;DR: The hypothesis that compulsive behaviors in PD are associated with reduced ventral and dorsal striatal D2/3 expression, similar to changes in comparable behavioral disorders is supported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: December 4, 2019

2018 article

Reproducibility of the correlative triad among aging, dopamine receptor availability, and cognition

Juarez, E. J., Castrellon, J. J., Green, M. A., Crawford, J. L., Seaman, K. L., Smith, C. T., … Samanez-Larkin, G. R. (2018, December 13). (Vol. 12). Vol. 12.

By: E. Juarez *, J. Castrellon *, M. Green *, J. Crawford *, K. Seaman *, C. Smith* , L. Dang *, D. Matuskey * ...

TL;DR: Examination of correlations among adult age, dopamine D2-like receptor (D2R) availability, and cognition in two cross-sectional studies of healthy human adults found no consistent evidence for significant associations between low D2R availability and low cognitive performance on these measures, and suggest caution in using PET measures as evidence of broad age-related declines in fluid cognition. (via Semantic Scholar)
Source: ORCID
Added: December 4, 2019

2018 journal article

Ventral striatal dopamine transporter availability is associated with lower trait motor impulsivity in healthy adults

Translational Psychiatry, 8(1).

By: C. Smith* , M. San Juan*, L. Dang *, D. Katz*, S. Perkins*, L. Burgess*, R. Cowan *, H. Manning* ...

MeSH headings : Adult; Aged; Dopamine Plasma Membrane Transport Proteins / metabolism; Exploratory Behavior / physiology; Female; Fluorodeoxyglucose F18; Humans; Impulsive Behavior / physiology; Male; Middle Aged; Personality; Personality Inventory; Positron-Emission Tomography; Ventral Striatum / metabolism; Young Adult
TL;DR: The data demonstrate that DAT availability in VS is negatively related to impulsivity and suggest a particular influence of DAT regulation of dopamine signaling in VS on acting without deliberation (BIS motor impulsivity). (via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 4, 2019

2018 journal article

[<sup>18</sup>F]fallypride characterization of striatal and extrastriatal D<inf>2/3</inf>receptors in Parkinson's disease

NeuroImage: Clinical, 18, 433–442.

By: A. Stark *, C. Smith* , K. Petersen *, P. Trujillo *, N. Wouwe *, M. Donahue *, R. Kessler*, A. Deutch*, D. Zald *, D. Claassen *

Contributors: A. Stark *, C. Smith* , K. Petersen *, P. Trujillo *, N. Wouwe *, M. Donahue *, R. Kessler*, A. Deutch*, D. Zald *, D. Claassen *

author keywords: Parkinson's disease; Dopamine; Positron emission tomography (PET); Neurodegeneration; Fallypride
MeSH headings : Aged; Aged, 80 and over; Benzamides / pharmacokinetics; Brain Mapping; Corpus Striatum / diagnostic imaging; Corpus Striatum / drug effects; Dopamine D2 Receptor Antagonists / pharmacokinetics; Female; Fluorodeoxyglucose F18 / pharmacokinetics; Humans; Magnetic Resonance Imaging; Male; Parkinson Disease / diagnostic imaging; Positron-Emission Tomography; Receptors, Dopamine D2 / metabolism
TL;DR: The hypothesis that abnormal D2/3 expression occurs in regions related to both the motor and non-motor symptoms of PD, including areas richly invested with noradrenergic neurons is supported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: December 4, 2019

2017 journal article

COMT Val158Met Polymorphism Exerts Sex-Dependent Effects on fMRI Measures of Brain Function

Frontiers in Human Neuroscience, 11.

By: A. Elton *, C. Smith* , M. Parrish * & C. Boettiger *

Contributors: A. Elton *, C. Smith* , M. Parrish * & C. Boettiger *

TL;DR: Testing healthy adults for COMT genotype and sex provided insight into the potential influences of COMT-regulated variations in catecholamine levels on brain function, which may represent endophenotypes for disorders of impulsivity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 4, 2019

2017 journal article

Neural systems underlying individual differences in intertemporal decision-making

Journal of Cognitive Neuroscience, 29(3), 467–479.

By: A. Elton, C. Smith* , M. Parrish & C. Boettiger

Contributors: A. Elton, C. Smith* , M. Parrish & C. Boettiger

MeSH headings : Adolescent; Adult; Alcohol-Related Disorders; Brain / diagnostic imaging; Brain / physiology; Brain Mapping; Delay Discounting / physiology; Female; Humans; Impulsive Behavior / physiology; Individuality; Linear Models; Magnetic Resonance Imaging; Male; Neural Pathways / diagnostic imaging; Neural Pathways / physiology; Neuropsychological Tests; Young Adult
TL;DR: Novel insight is provided into the neural underpinnings of individual differences in impulsive decision-making with potential implications for addiction and related disorders in which impulsivity is a defining feature. (via Semantic Scholar)
Source: ORCID
Added: December 4, 2019

2017 journal article

The impact of common dopamine D2 receptor gene polymorphisms on D2/3 receptor availability: C957T as a key determinant in putamen and ventral striatum

Translational Psychiatry, 7(4), e1091–e1091.

By: C. Smith* , L. Dang *, J. Buckholtz*, A. Tetreault*, R. Cowan *, R. Kessler, D. Zald *

Contributors: C. Smith* , L. Dang *, J. Buckholtz*, A. Tetreault*, R. Cowan *, R. Kessler, D. Zald *

MeSH headings : Adolescent; Adult; Alleles; Benzamides; Dopamine / physiology; Female; Fluorine Radioisotopes; Genetic Determinism; Genetic Linkage; Genotype; Humans; Image Interpretation, Computer-Assisted; Male; Polymorphism, Single Nucleotide / genetics; Positron-Emission Tomography; Putamen / diagnostic imaging; Putamen / metabolism; Receptors, Dopamine D2 / genetics; Receptors, Dopamine D2 / metabolism; Receptors, Dopamine D3 / genetics; Signal Transduction / genetics; Ventral Striatum / diagnostic imaging; Ventral Striatum / metabolism; Young Adult
TL;DR: The largest PET genetic study to date, testing for effects of the C957T and -141C Ins/Del SNPs as well as Taq1A on BPND of the high-affinity D2 receptor tracer 18F-Fallypride, found a positive linear effect of C 957T T allele status on striatal BPND bilaterally. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 4, 2019

2016 journal article

Individual differences in timing of peak positive subjective responses to d-amphetamine: Relationship to pharmacokinetics and physiology

Journal of Psychopharmacology, 30(4), 330–343.

By: C. Smith* , J. Weafer *, R. Cowan *, R. Kessler, A. Palmer*, H. De Wit*, D. Zald *

Contributors: C. Smith* , J. Weafer *, R. Cowan *, R. Kessler, A. Palmer*, H. De Wit*, D. Zald *

author keywords: d-amphetamine; subjective effects; individual differences; pharmacokinetics; addiction
MeSH headings : Adult; Behavior, Addictive / blood; Behavior, Addictive / chemically induced; Behavior, Addictive / metabolism; Central Nervous System Stimulants / blood; Central Nervous System Stimulants / pharmacokinetics; Central Nervous System Stimulants / pharmacology; Dextroamphetamine / blood; Dextroamphetamine / pharmacokinetics; Dextroamphetamine / pharmacology; Dose-Response Relationship, Drug; Female; Heart Rate / drug effects; Humans; Individuality; Male; Substance-Related Disorders / blood; Substance-Related Disorders / etiology; Substance-Related Disorders / metabolism; Surveys and Questionnaires; Young Adult
TL;DR: The present data illustrate the presence of significant individual differences in the temporal pattern of responses to oral d-amphetamine, which may contribute to heightened abuse potential. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: December 4, 2019

2016 journal article

Variability in paralimbic dopamine signaling correlates with subjective responses to d-amphetamine

Neuropharmacology, 108, 394–402.

By: C. Smith* , L. Dang *, R. Cowan *, R. Kessler & D. Zald *

author keywords: d-amphetamine; Dopamine; Ventromedial PFC; Insula; Ventral striatum
MeSH headings : Administration, Oral; Adolescent; Adult; Central Nervous System Stimulants / administration & dosage; Corpus Striatum / diagnostic imaging; Corpus Striatum / drug effects; Corpus Striatum / metabolism; Dextroamphetamine / administration & dosage; Dopamine / metabolism; Humans; Male; Positron-Emission Tomography / methods; Prefrontal Cortex / diagnostic imaging; Prefrontal Cortex / drug effects; Prefrontal Cortex / metabolism; Receptors, Dopamine D2 / metabolism; Signal Transduction / drug effects; Signal Transduction / physiology; Young Adult
TL;DR: Characteristics of DA functioning in vmPFC, a cortical area implicated in subjective valuation, are associated with both subjective high and incentive (wanting) responses, which highlight the importance of variability in DA signaling in specific paralimbic cortical regions in dAMPH's subjective response, which may confer risk for abusing psychostimulants. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: December 4, 2019

2015 journal article

Intertemporal Choice Behavior in Emerging Adults and Adults: Effects of Age Interact with Alcohol Use and Family History Status

Front. Hum. Neurosci., 9.

By: C. Smith* , E. Steel*, M. Parrish *, M. Kelm* & C. Boettiger *

author keywords: alcoholism; family history; decision-making; delay-discounting; impulsivity
TL;DR: Findings lend support for elevated Now bias in adulthood as an intermediate phenotype for AUDs, and non-additive effects of age and heavy drinking on Now bias suggest perturbations in largely common neural circuits in both groups. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: December 4, 2019

2015 journal article

Modulation of impulsivity and reward sensitivity in intertemporal choice by striatal and midbrain dopamine synthesis in healthy adults

J Neurophysiol, 115(3), 1146–1156.

By: C. Smith* , D. Wallace *, L. Dang *, E. Aarts *, W. Jagust *, M. D'Esposito *, C. Boettiger *

author keywords: delay discounting; immediate reward bias; impulsive choice; putamen; ventral tegmental area
MeSH headings : Adult; Choice Behavior; Dopamine / metabolism; Female; Humans; Impulsive Behavior; Male; Mesencephalon / diagnostic imaging; Mesencephalon / metabolism; Mesencephalon / physiology; Positron-Emission Tomography; Putamen / diagnostic imaging; Putamen / metabolism; Putamen / physiology; Radiopharmaceuticals; Reaction Time; Reward; Tyrosine / analogs & derivatives
TL;DR: It is demonstrated that intertemporal reward choice in healthy humans varies with region-specific measures of DA processing, with regionally distinct associations with sensitivity to delay and to reward magnitude. (via Semantic Scholar)
Source: ORCID
Added: December 4, 2019

2014 journal article

Comprehensive interrogation of CpG island methylation in the gene encoding COMT, a key estrogen and catecholamine regulator

BMC Medical Genomics, 7(1).

By: T. Swift-Scanlan*, C. Smith* , S. Bardowell * & C. Boettiger *

Contributors: T. Swift-Scanlan*, C. Smith* , S. Bardowell * & C. Boettiger *

MeSH headings : Adult; Breast Neoplasms / enzymology; Breast Neoplasms / genetics; Catechol O-Methyltransferase / genetics; Catechol O-Methyltransferase / metabolism; Catecholamines / metabolism; Cell Line, Tumor; Cluster Analysis; CpG Islands / genetics; DNA Methylation / genetics; Estrogens / metabolism; Female; Gene Expression Regulation, Neoplastic; Humans; Male
TL;DR: This work comprehensively interrogated methylation in over 200 CpG dinucleotide sequences spanning the length of the catechol-O-methyltransferase (COMT) gene, corroborate previous findings of variation in COMT methylation with gene expression and the Val158Met genotype, and report novel associations with socioeconomic status (SES) and ethnicity at several methylated loci. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: December 4, 2019

2014 journal article

Erratum: Age modulates the effect of COMT genotype on delay discounting behavior (Psychopharmacology (2012) 222 (609617) (DOI 10.1007/s00213-012-2653-9) )

Psychopharmacology, 231(3), 621.

By: C. Smith*  & C. Boettiger *

Contributors: C. Smith*  & C. Boettiger *

Source: ORCID
Added: December 4, 2019

2014 journal article

Genetic polymorphisms regulating dopamine signaling in the frontal cortex interact to affect target detection under high working memory load

Journal of Cognitive Neuroscience, 26(2), 395–407.

By: C. Smith* , T. Swift-Scanlan & C. Boettiger

Contributors: C. Smith* , T. Swift-Scanlan & C. Boettiger

MeSH headings : Adult; Black People; Catechol O-Methyltransferase / genetics; DNA / genetics; Data Interpretation, Statistical; Discrimination, Psychological / physiology; Dopamine / physiology; Dopamine and cAMP-Regulated Phosphoprotein 32 / genetics; Dopamine and cAMP-Regulated Phosphoprotein 32 / physiology; Educational Status; Executive Function / physiology; Female; Genotype; Humans; Male; Memory, Short-Term / physiology; Minisatellite Repeats; Polymerase Chain Reaction; Polymorphism, Genetic / physiology; Polymorphism, Single Nucleotide; Prefrontal Cortex / physiology; Psychomotor Performance / physiology; Receptors, Dopamine D1 / genetics; Receptors, Dopamine D1 / physiology; Signal Transduction / genetics; White People; Young Adult
TL;DR: It is suggested that enhanced dopaminergic signaling via the DARPP-32 T allele aids target detection in individuals with presumed low frontal DA (COMTValVal) but impairs target Detection in those with putatively higher frontal DA levels (COMTMet carriers). (via Semantic Scholar)
Source: ORCID
Added: December 4, 2019

2014 journal article

Ovarian cycle effects on immediate reward selection bias in humans: A role for estradiol

Journal of Neuroscience, 34(16), 5468–5476.

By: C. Smith* , Y. Sierra, S. Oppler & C. Boettiger *

Contributors: C. Smith* , Y. Sierra, S. Oppler & C. Boettiger *

MeSH headings : Adolescent; Adult; Analysis of Variance; Catechol O-Methyltransferase / genetics; Decision Making / physiology; Dopamine / metabolism; Estradiol / metabolism; Female; Genotype; Humans; Menstrual Cycle / genetics; Menstrual Cycle / physiology; Polymorphism, Single Nucleotide / genetics; Psychometrics; Reward; Saliva / metabolism; Selection Bias; Young Adult
TL;DR: This is the first demonstration that intertemporal choice varies across the ovarian cycle, with Now bias declining at mid-cycle, when fertility peaks, and the interacting effects of estradiol and frontal DA mediate this cycle effect on decision making. (via Semantic Scholar)
Source: ORCID
Added: December 4, 2019

2012 journal article

Age modulates the effect of COMT genotype on delay discounting behavior

Psychopharmacology, 222(4), 609–617.

By: C. Smith*  & C. Boettiger *

Contributors: C. Smith*  & C. Boettiger *

author keywords: Adolescence; Decision-making; Delay discounting; Development; Dopamine; Impulsivity
MeSH headings : Adolescent; Adult; Age Factors; Alleles; Catechol O-Methyltransferase / genetics; Cross-Sectional Studies; Female; Genotype; Humans; Impulsive Behavior / genetics; Impulsive Behavior / psychology; Male; Polymorphism, Single Nucleotide
TL;DR: A single U-shaped model of the relationship between frontal DA levels and impulsive choice that accounts for both adolescent and adult data is proposed and confirmed the previous finding of enhanced delay-discounting among val/val adults relative to met-allele carriers. (via Semantic Scholar)
Source: ORCID
Added: December 4, 2019

Employment

Updated: February 15th, 2023 15:54

2022 - present

Virginia Tech Blacksburg, Virginia, US
Postdoctoral Affairs Program Administrator Office of Research and Innovation

2019 - 2022

North Carolina State University Raleigh, North Carolina, US
Postdoctoral Affairs Program Manager The Graduate School

2014 - 2019

Vanderbilt University Nashville, TN, US
Postdoctoral Research Fellow Psychology

Education

Updated: December 9th, 2014 12:45

2008 - 2014

University of North Carolina at Chapel Hill Chapel Hill, NC, US
PhD Neurobiology Neurobiology

Funding History

Funding history based on the linked ORCID record. Updated: May 10th, 2016 06:40

grant June 1, 2016 - May 1, 2019
Linking Temporal Differences in d-Amphetamine Subjective Effects to DRD2 and DAT
National Institute on Drug Abuse
grant August 1, 2011 - July 31, 2014
Now versus Later decision Making: Effects of frontal development and alcohol use
National Institute on Alcohol Abuse and Alcoholism

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