Connor Willis
College of Sciences
Works (3)
Updated: August 7th, 2023 21:16
2023 journal article
Comparison of Aptamer Signaling Mechanisms Reveals Disparities in Sensor Response and Strategies to Eliminate False Signals
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 145(22), 12407–12422.
MeSH headings : Aptamers, Nucleotide / chemistry; DNA; DNA, Complementary; Sensitivity and Specificity; SELEX Aptamer Technique / methods; Biosensing Techniques / methods
TL;DR:
This work has developed a series of sensors using aptamers for the small-molecule drugs flunixin, fentanyl, and furanyl fentanyl and compares their performance, focusing on their specificity, and demonstrates strategies for improving the sensitivity and specificity of aptamer sensors with the development of a "hybrid beacon".
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 19, 2023
2023 article
Suite of Aptamer-Based Sensors for the Detection of Fentanyl and Its Analogues
Canoura, J., Liu, Y., Perry, J., Willis, C., & Xiao, Y. (2023, April 25). ACS SENSORS, Vol. 4.
author keywords: aptamers; fentanyl; analogue; electrochemistry; colorimetry; fluorescence; bioanalytical; sensors
MeSH headings : Humans; United States; Fentanyl; Analgesics, Opioid; Illicit Drugs; Drug Overdose; Immunoassay
TL;DR:
A series of new aptamer-based assays and sensors that can detect fentanyl as well as several of its analogues in a reliable, accurate, rapid, and economic manner are developed and foresee the potential for routine use by medical and law enforcement personnel aswell as the general public to aid in rapid and accurate fentanyl identification.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: May 30, 2023
2022 article
High-throughput quantitative binding analysis of DNA aptamers using exonucleases
Canoura, J., Alkhamis, O., Liu, Y., Willis, C., & Xiao, Y. (2022, December 30). NUCLEIC ACIDS RESEARCH, Vol. 12.
MeSH headings : Aptamers, Nucleotide / chemical synthesis; Aptamers, Nucleotide / chemistry; Exonucleases; Ligands; Nucleic Acids; SELEX Aptamer Technique / methods; Fentanyl / analysis; Robotics
TL;DR:
This work has developed a high-throughput method for accurately quantifying aptamer binding affinity, specificity, and cross-reactivity via the kinetics of aptamer digestion by exonucleases and this approach dramatically accelerates the aptamer characterization process and streamlines sensor development.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 17, 2023