@article{wang_ye_hochu_sadeghifar_gu_2016, title={Enhanced Cancer Immunotherapy by Microneedle Patch-Assisted Delivery of Anti-PD1 Antibody}, volume={16}, ISSN={["1530-6992"]}, DOI={10.1021/acs.nanolett.5b05030}, abstractNote={Despite recent advances in melanoma treatment through the use of anti-PD-1 (aPD1) immunotherapy, the efficacy of this method remains to be improved. Here we report an innovative self-degradable microneedle (MN) patch for the sustained delivery of aPD1 in a physiologically controllable manner. The microneedle is composed of biocompatible hyaluronic acid integrated with pH-sensitive dextran nanoparticles (NPs) that encapsulate aPD1 and glucose oxidase (GOx), which converts blood glucose to gluconic acid. The generation of acidic environment promotes the self-dissociation of NPs and subsequently results in the substantial release of aPD1. We find that a single administration of the MN patch induces robust immune responses in a B16F10 mouse melanoma model compared to MN without degradation trigger or intratumoral injection of free aPD1 with the same dose. Moreover, this administration strategy can integrate with other immunomodulators (such as anti-CTLA-4) to achieve combination therapy for enhancing antitumor efficacy.}, number={4}, journal={NANO LETTERS}, author={Wang, Chao and Ye, Yanqi and Hochu, Gabrielle M. and Sadeghifar, Hasan and Gu, Zhen}, year={2016}, month={Apr}, pages={2334–2340} }
 @article{wang_kelley_venditti_2016, title={Lignin-Based Thermoplastic Materials}, volume={9}, ISSN={1864-5631}, url={http://dx.doi.org/10.1002/cssc.201501531}, DOI={10.1002/cssc.201501531}, abstractNote={Abstract}, number={8}, journal={ChemSusChem}, publisher={Wiley}, author={Wang, Chao and Kelley, Stephen S. and Venditti, Richard A.}, year={2016}, month={Apr}, pages={770–783} }
 @article{wang_venditti_2015, title={UV Cross-Linkable Lignin Thermoplastic Graft Copolymers}, volume={3}, ISSN={2168-0485 2168-0485}, url={http://dx.doi.org/10.1021/acssuschemeng.5b00416}, DOI={10.1021/acssuschemeng.5b00416}, abstractNote={This work highlighted a new method to prepare UV curable lignin thermoplastic copolymers, which are expected to show applications as functional materials (e.g., carbon fiber precursors) with improved thermal stability, solvent resistance and surface hardness. UV cross-linkable lignin graft copolymers were synthesized via activator regenerated by electron transfer (ARGET) atom transfer radical polymerization (ATRP) and characterized. By incorporating a photosensitive compound, acryloyl benzophenone (ABP), as a comonomer during the polymerization, lignin-g-poly(styrene-co-ABP) copolymers with 6–9% (mol %) of ABP moieties were obtained. The lignin graft copolymers showed similar glass transition temperature (∼100 °C) as polystyrene. The carbon yields during pyrolysis decreased as the degrees of polymerization of the graft copolymers increased. Under UV irradiation, up to ∼30 wt % of the lignin-g-poly(styrene-co-ABP) copolymers cross-linked to form polymer networks, whereas less than ∼5 wt % of the lignin-g-p...}, number={8}, journal={ACS Sustainable Chemistry & Engineering}, publisher={American Chemical Society (ACS)}, author={Wang, Chao and Venditti, Richard A.}, year={2015}, month={Jul}, pages={1839–1845} }