@article{zheng_tang_huang_wu_2022, title={An O(N) algorithm for computing expectation of N-dimensional truncated multi-variate normal distribution II: computing moments and sparse grid acceleration}, volume={48}, ISSN={["1572-9044"]}, DOI={10.1007/s10444-022-09988-6}, number={6}, journal={ADVANCES IN COMPUTATIONAL MATHEMATICS}, author={Zheng, Chaowen and Tang, Zhuochao and Huang, Jingfang and Wu, Yichao}, year={2022}, month={Dec} } @article{zheng_wu_2020, title={Tuning parameter selection for penalised empirical likelihood with a diverging number of parameters}, volume={32}, ISSN={["1029-0311"]}, DOI={10.1080/10485252.2020.1717491}, abstractNote={ABSTRACT Penalised likelihood methods have been a success in analysing high dimensional data. Tang and Leng [(2010), ‘Penalized High-Dimensional Empirical Likelihood’, Biometrika, 97(4), 905–920] extended the penalisation approach to the empirical likelihood scenario and showed that the penalised empirical likelihood estimator could identify the true predictors consistently in the linear regression models. However, this desired selection consistency property of the penalised empirical likelihood method relies heavily on the choice of the tuning parameter. In this work, we propose a tuning parameter selection procedure for penalised empirical likelihood to guarantee that this selection consistency can be achieved. Specifically, we propose a generalised information criterion (GIC) for the penalised empirical likelihood in the linear regression case. We show that the tuning parameter selected by the GIC yields the true model consistently even when the number of predictors diverges to infinity with the sample size. We demonstrate the performance of our procedure by numerical simulations and a real data analysis.}, number={1}, journal={JOURNAL OF NONPARAMETRIC STATISTICS}, author={Zheng, Chaowen and Wu, Yichao}, year={2020}, month={Jan}, pages={246–261} } @article{oh_foster_williams_zheng_ru_lunn_mowat_2019, title={Diagnostic utility of clinical and laboratory test parameters for differentiating between sudden acquired retinal degeneration syndrome and pituitary‐dependent hyperadrenocorticism in dogs}, volume={22}, ISSN={1463-5216 1463-5224}, url={http://dx.doi.org/10.1111/vop.12661}, DOI={10.1111/vop.12661}, abstractNote={AbstractObjectiveTo identify discriminating factors, using clinical ophthalmic examination findings and routine laboratory testing, that differentiate dogs with early sudden acquired retinal degeneration (SARDS; vision loss <6 weeks’ duration), age‐ and breed‐matched control dogs, and dogs with pituitary‐dependent hyperadrenocorticism (PDH).AnimalsClient‐owned dogs: 15 with SARDS with <6 weeks duration of vision loss, 14 age‐ and breed‐matched control dogs, and 13 dogs with confirmed PDH.ProceduresDogs underwent ophthalmic examination, electroretinography (ERG) fundus photography, and spectral‐domain optical coherence tomography (SD‐OCT) in addition to physical examination, urinalysis, serum biochemistry, complete blood count, and adrenocorticotrophic hormone (ACTH) stimulation testing. Statistical analysis was performed using receiver operating curve area under the curve analysis, principal component analysis with sparse partial least squares analysis, and one‐way ANOVA.ResultsDogs with SARDS all had absent vision and ERG a‐ and b‐waves. SD‐OCT demonstrated that dogs with SARDS had significantly thicker inner retina, thinner outer nuclear layer, and thicker photoreceptor inner/outer segment measurements than either controls or dogs with PDH. Discriminating laboratory parameters between dogs with SARDS and PDH with high specificity included post‐ACTH serum cortisol (<19.3 μg/dL), AST:ALT ratio (>0.343), and urine specific gravity (>1.030).Conclusions and Clinical RelevanceWe have identified significant discriminators between SARDS and PDH. This work provides the basis for future studies that could identify and examine dogs with SARDS prior to vision loss, which may extend the potential therapeutic window for SARDS.}, number={6}, journal={Veterinary Ophthalmology}, publisher={Wiley}, author={Oh, Annie and Foster, Melanie L. and Williams, Jonathan G. and Zheng, Chaowen and Ru, Hongyu and Lunn, Katharine F. and Mowat, Freya M.}, year={2019}, month={Mar}, pages={842–858} } @article{zheng_wu_2020, title={Nonparametric Estimation of Multivariate Mixtures}, volume={115}, ISSN={["1537-274X"]}, DOI={10.1080/01621459.2019.1635481}, abstractNote={A multivariate mixture model is determined by three elements: the number of components, the mixing proportions, and the component distributions. Assuming that the number of components is given and ...}, number={531}, journal={JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION}, author={Zheng, Chaowen and Wu, Yichao}, year={2020}, month={Jul}, pages={1456–1471} } @article{young_zheng_davidson_westermeyer_2019, title={Visual outcome in cats with hypertensive chorioretinopathy}, volume={22}, ISSN={["1463-5224"]}, url={https://doi.org/10.1111/vop.12575}, DOI={10.1111/vop.12575}, abstractNote={AbstractPurposeTo investigate factors associated with long‐term visual outcome in cats with hypertensive chorioretinopathy.Animals studiedEighty‐eight client‐owned cats diagnosed with hypertensive chorioretinopathy.ProcedureMedical records from cats with systemic hypertension and associated retinal lesions were reviewed.ResultsMost cats (61%) were blind in both eyes at presentation. Presence of menace response at last follow‐up evaluation was positively correlated with presence of menace response at presentation (P = .0025), time to complete retinal reattachment (P < .0001), and gender (P = .0137). Seventy‐six of 132 eyes (57.6%) that were blind at presentation regained some vision following treatment. At the time of last evaluation, 101/176 eyes (60%) had a positive menace response, while 34/46 (74%) eyes with a follow‐up of >6 months had a positive menace response. Eyes that had a menace response at presentation were 17 and 37 times more likely to have a menace response at last examination compared to eyes blind for less than 2 weeks and eyes blind greater than 2 weeks, respectively. Female cats were overrepresented (62.5% of cases), and male cats were 4.2 times more likely to be visual at time of last examination compared to female cats.ConclusionsWith treatment, the prognosis for long‐term vision in cats with hypertensive chorioretinopathy, even following complete retinal detachment, is good.}, number={2}, journal={VETERINARY OPHTHALMOLOGY}, author={Young, Whitney M. and Zheng, Chaowen and Davidson, Michael G. and Westermeyer, Hans D.}, year={2019}, month={Mar}, pages={161–167} }