Works (18)
Updated: April 4th, 2024 13:22
2024 journal article
Flunixin meglumine tissue residues after intravenous administration in goats
FRONTIERS IN VETERINARY SCIENCE, 10.
author keywords: flunixin; goat; residues; tolerance limit method; withdrawal interval; withdrawal time
TL;DR:
Since any detection of flunixin residues at slaughter found in goat tissues is considered a violative residue, a conservative withdrawal interval of 17 days was calculated to ensure levels of flunixin fell below the regulatory limits of detection in liver, kidney, and muscle tissues.
(via Semantic Scholar)
www.frontiersin.org (publisher PDF)
Sources: Web Of Science, ORCID
Added: February 12, 2024
2023 journal article
Milk residues following multiple doses of meloxicam and gabapentin in lactating dairy cattle
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 261(12), 1873–1879.
author keywords: meloxicam; gabapentin; lactation; postpartum; dairy cattle
TL;DR:
Results of this study suggest that milk from cows treated with multiple doses of meloxicam alone or in combination with gabapentin will have low drug concentrations and falls below the reported limit of detection formeloxicam or gABapentin 120 and 60 hours respectively, following the final dose regardless of their stage of lactation.
(via Semantic Scholar)
Sources: ORCID, Web Of Science
Added: February 1, 2024
2021 journal article
Pharmacokinetics of grapiprant in goat kids at two different dosing regimens
Small Ruminant Research, 205, 106531.
Source: ORCID
Added: February 1, 2024
2019 journal article
Comparative plasma and urine concentrations of flunixin and meloxicam in goats
SMALL RUMINANT RESEARCH, 174, 40–46.
TL;DR:
The information from this study represents a potential worst-case scenario for urine depletion and helps determine the withdrawal intervals needed for flunixin meglumine in show goats when administered in this extra label manner.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: June 4, 2019
2019 journal article
Impact of bovine respiratory disease on the pharmacokinetics of danofloxacin and tulathromycin in different ages of calves
PLOS ONE, 14(6).
Ed(s): D. Gladue
MeSH headings : Age Factors; Animals; Area Under Curve; Bronchoalveolar Lavage Fluid / chemistry; Cattle; Cattle Diseases / drug therapy; Disaccharides / administration & dosage; Disaccharides / pharmacokinetics; Extracellular Fluid / chemistry; Female; Fluoroquinolones / administration & dosage; Fluoroquinolones / pharmacokinetics; Heterocyclic Compounds / administration & dosage; Heterocyclic Compounds / pharmacokinetics; Pasteurella Infections / drug therapy; Pasteurella Infections / veterinary; Pasteurella multocida / pathogenicity; Respiration Disorders / drug therapy; Respiration Disorders / veterinary
TL;DR:
Age was determined to be a significant covariate for calves administered danofloxacin and tulathromycin for plasma PK parameters and potential reasons for age-related differences on plasma concentration–time profiles and the impact of disease on the partitioning of the drug from the blood to the lungs and ISF as a function of age are explored.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: September 30, 2019
2018 journal article
Automation and applications of the tolerance limit method in estimating meat withdrawal periods for veterinary drugs
COMPUTERS AND ELECTRONICS IN AGRICULTURE, 146, 125–135.
author keywords: Withdrawal time calculator; R studio; Maximum residue limit; Tolerance; US FDA
TL;DR:
A novel program provides a platform to calculate a withdrawal period recommendation for any drug in any class of animal for various regulatory body standards and could be very helpful in cases of extra-label drug use in food animals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2018 journal article
Effect of age on plasma protein binding of several veterinary drugs in dairy Check for calves 2
RESEARCH IN VETERINARY SCIENCE, 121, 59–64.
author keywords: Protein binding; Calves; Alpha-1-acid glycoprotein; Albumin
MeSH headings : Age Factors; Animals; Blood Proteins / metabolism; Cattle / metabolism; Protein Binding; Veterinary Drugs / metabolism
TL;DR:
Findings from these calves suggest that age is not an important factor in the binding of these drugs to plasma proteins, and statistically significant age-effects on plasma protein binding were not observed for any of the drugs evaluated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: December 17, 2018
2018 journal article
Effect of age on the pharmacokinetics and distribution of tulathromycin in interstitial and pulmonary epithelial lining fluid in healthy calves
American Journal of Veterinary Research, 79(11), 1193–1203.
MeSH headings : Animals; Anti-Bacterial Agents / pharmacokinetics; Bronchoalveolar Lavage Fluid; Cattle; Disaccharides / pharmacokinetics; Extracellular Fluid / drug effects; Heterocyclic Compounds / pharmacokinetics; Lung / metabolism; Male
TL;DR:
It is suggested that age affected multiple pharmacokinetic parameters of tulathromycin, likely owing to physiologic changes as calves mature from preruminants to ruminants.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Crossref
Added: August 28, 2019
2018 journal article
Use of an ultrafiltration device in gland cistern for continuous sampling of healthy and mastitic quarters of lactating cattle for pharmacokinetic modeling
JOURNAL OF DAIRY SCIENCE, 101(11), 10414–10420.
MeSH headings : Administration, Intravenous / veterinary; Animals; Cattle; Chromatography, High Pressure Liquid / veterinary; Clonixin / analogs & derivatives; Clonixin / blood; Clonixin / pharmacokinetics; Feasibility Studies; Female; Lactation; Mammary Glands, Animal / metabolism; Mass Spectrometry / veterinary; Mastitis, Bovine / diagnosis; Milk / chemistry; Ultrafiltration / veterinary
TL;DR:
Collection of ultrafiltration samples from the mammary gland of cows provides a viable means to continuously assess drug concentrations in the milk while continuing to milk the cow normally, and demonstrates the utility of continuous sampling of milk via ultraFiltration for future pharmacokinetic studies in cattle.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: NC State University Libraries, ORCID
Added: November 5, 2018
2017 journal article
Avoiding violative flunixin meglumine residues in cattle and swine
Journal of the American Veterinary Medical Association, 250(2), 182–189.
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / chemistry; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Cattle; Clonixin / analogs & derivatives; Clonixin / chemistry; Clonixin / pharmacokinetics; Drug Residues / pharmacokinetics; Swine
TL;DR:
In the United States, NSAIDs are among the most frequently administered drugs for analgesia in cattle; however, such use is considered extralabel and must be in accordance with AMDUCA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: NC State University Libraries, ORCID, Crossref
Added: August 6, 2018
2017 journal article
Considerations for extralabel drug use in calves
Journal of the American Veterinary Medical Association, 250(11), 1275–1282.
MeSH headings : Animals; Animals, Newborn; Cattle; Drug Labeling; Drug Residues; Food Contamination; Meat; Milk; Veterinary Drugs / administration & dosage; Veterinary Drugs / pharmacokinetics
TL;DR:
The purpose of this digest is to provide veterinarians with a summary of the considerations for ELDU in both beef and dairy calves as well as calves intended for veal production.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2017 journal article
Pharmacokinetics and distribution in interstitial and pulmonary epithelial lining fluid of danofloxacin in ruminant and preruminant calves
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 40(2), 179–191.
MeSH headings : Animals; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / metabolism; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Body Fluids / chemistry; Cattle / physiology; Digestion / physiology; Fluoroquinolones / chemistry; Fluoroquinolones / metabolism; Fluoroquinolones / pharmacokinetics; Half-Life
TL;DR:
Comparison of active drug concentrations in the plasma vs. different effector compartments of healthy preruminating and ruminating calves found that ruminant calves maintained higher ISF/plasma concentration ratios throughout the study period compared to that observed in preruminant calves.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2016 journal article
Health concerns and management of select veterinary drug residues
Food and Chemical Toxicology, 88, 112–122.
author keywords: Drug; Veterinary; Residue; Adverse; Livestock
MeSH headings : Animals; Carcinogens; Drug Residues / adverse effects; Humans; Veterinary Drugs / chemistry; Veterinary Drugs / metabolism; Veterinary Drugs / pharmacokinetics
TL;DR:
The aim of this manuscript is to review the potential adverse health effects in humans if exposed to residues of selected veterinary drugs used in food-producing animals and how regulatory and independent organizations manage the risk of these veterinary drugs based on data from human health risk assessments.
(via Semantic Scholar)
Sources: ORCID, Crossref
Added: February 24, 2020
2014 journal article
Tetracycline Residues in Porcine Stomach after Administration via Drinking Water on a Swine Farm
JOURNAL OF FOOD PROTECTION, 77(1), 122–126.
MeSH headings : Animals; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Chromatography, High Pressure Liquid / veterinary; Drug Residues / analysis; Europe; Meat / analysis; Monte Carlo Method; Russia; Stomach / chemistry; Swine; Tetracycline / blood; Tetracycline / pharmacokinetics; United States; Water / chemistry
TL;DR:
It is demonstrated that tetracycline residues are still detectable in the stomach tissues after the established United States withdrawal time of 4 days, which may explain why stomach tissues tested in Russia and Europe show positive residues for tetrACYcline, even though the meat may pass inspection here in the United States prior to export.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2010 journal article
Terminology Challenges: Defining Modified Release Dosage Forms in Veterinary Medicine
Journal of Pharmaceutical Sciences, 99(8), 3281–3290.
TL;DR:
This manuscript reflects an initial effort to suggest definitions that may be appropriate for describing formulation effects in veterinary medicine.
(via Semantic Scholar)
Source: ORCID
Added: February 1, 2024
journal article
Comparative urine residues of flunixin and meloxicam in show goats
Bublitz, C. M., Mzyk, D. A., Mays, T., Fajt, V. R., Hairgrove, T., & Baynes, R. E. Journal of Veterinary Pharmacology and Therapeutics, 41, 24–24.
Source: NC State University Libraries
Added: August 6, 2018
review
Health concerns and management of select veterinary drug residues
Baynes, R. E., Dedonder, K., Kissell, L., Mzyk, D., Marmulak, T., Smith, G., … Riviere, J. E. [Review of ]. Food and Chemical Toxicology, 88, 112–122.
Source: NC State University Libraries
Added: August 6, 2018
journal article
Impact of bovine respiratory disease on the pharmacokinetics of danofloxacin and tulathromycin in different ages of calves
Mzyk, D. A., Bublitz, C. M., Martinez, M. N., Davis, J. L., Baynes, R. E., & Smith, G. W. Journal of Veterinary Pharmacology and Therapeutics, 41, 33–33.
Source: NC State University Libraries
Added: August 6, 2018
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