Davis A. Ranson

Works (3)

Updated: July 5th, 2023 15:40

2016 journal article

Internalized compartments encapsulated nanogels for targeted drug delivery

NANOSCALE, 8(17), 9178–9184.

By: J. Yu n, Y. Zhang n, W. Sun n, C. Wang n, D. Ranson n, Y. Ye n, Y. Weng *, Z. Gu n

MeSH headings : Doxorubicin / administration & dosage; Drug Delivery Systems; Ferrous Compounds; Hyaluronic Acid; Nanoparticles; Silicon Dioxide
TL;DR: This study illustrates the potential of utilizing an internalized compartments encapsulated formulation for targeted cancer therapy, and offers guidelines for developing a natural particulate-inspired drug delivery system. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Engineering Synthetic Insulin-Secreting Cells Using Hyaluronic Acid Microgels Integrated with Glucose-Responsive Nanoparticles

CELLULAR AND MOLECULAR BIOENGINEERING, 8(3), 445–454.

By: J. Di n, J. Yu n, Y. Ye n, D. Ranson n, A. Jindal n & Z. Gu n

author keywords: Insulin delivery; Diabetes; Glucose responsive; Bio-inspired; Hyaluronic acid; Dextran
TL;DR: In vitro studies demonstrated that the insulin release rate associated with HA microgels was effectively regulated by changes in the glucose concentration, and validated that a single injection of the developed formulation stabilized the blood glucose levels in the normoglycemic state for over 1 week. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 112(27), 8260–8265.

By: J. Yu n, Y. Zhang n, Y. Ye n, R. DiSanto n, W. Sun n, D. Ranson n, F. Ligler n, J. Buse *, Z. Gu n

author keywords: diabetes; drug delivery; glucose-responsive; hypoxia-sensitive; microneedle
MeSH headings : Animals; Blood Glucose / analysis; Diabetes Mellitus, Experimental / blood; Diabetes Mellitus, Experimental / drug therapy; Diabetes Mellitus, Type 1 / blood; Diabetes Mellitus, Type 1 / drug therapy; Drug Delivery Systems / instrumentation; Drug Delivery Systems / methods; Glucose / metabolism; Glucose Oxidase / metabolism; Humans; Hyaluronic Acid / chemistry; Hyaluronic Acid / metabolism; Hypoglycemic Agents / administration & dosage; Hypoglycemic Agents / chemistry; Hypoxia / metabolism; Insulin / administration & dosage; Insulin / chemistry; Insulin / metabolism; Male; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Molecular Structure; Oxidation-Reduction; Reproducibility of Results
TL;DR: The “smart insulin patch” with a new enzyme-based glucose-responsive mechanism can regulate the blood glucose of type 1 diabetic mice to achieve normal levels, with faster responsiveness compared with the commonly used pH-sensitive formulations, and can avoid the risk of hypoglycemia. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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