Updated: October 1st, 2024 06:08

2024 article

Datopotamab-deruxtecan in early-stage breast cancer: the sequential multiple assignment randomized I-SPY2.2 phase 2 trial

Khoury, K., Meisel, J. L., Yau, C., Rugo, H. S., Nanda, R., Davidian, M., … Esserman, L. J. (2024, September 14). *NATURE MEDICINE*, Vol. 9.

Sources: Web Of Science, NC State University Libraries

Added: September 23, 2024

2024 article

Datopotamab-deruxtecan plus durvalumab in early-stage breast cancer: the sequential multiple assignment randomized I-SPY2.2 phase 2 trial

Shatsky, R. A., Trivedi, M. S., Yau, C., Nanda, R., Rugo, H. S., Davidian, M., … Esserman, L. J. (2024, September 14). *NATURE MEDICINE*, Vol. 9.

Sources: Web Of Science, NC State University Libraries

Added: September 23, 2024

2024 article

Estimation of optimal treatment regimes with electronic medical record data using the residual life value estimator

Rhodes, G., Davidian, M., & Lu, W. (2024, February 9). *BIOSTATISTICS*, Vol. 2.

author keywords: context vector; dynamic treatment regime; electronic medical record; MIMIC-III; precision medicine; Q-learning; random forest; residual life; sepsis

TL;DR:
ReLiVE-Q leverages accumulating patient information to estimate personalized treatment regimes that optimize a clinically meaningful function of residual life, and it is demonstrated that ReLiVE-Q leverages accumulating patient information to estimate personalized treatment regimes that optimize a clinically meaningful function of residual life.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: February 19, 2024

2023 journal article

Behavioral cancer pain intervention dosing: results of a Sequential Multiple Assignment Randomized Trial

*PAIN*, *164*(9), 1935–1941.

author keywords: Behavioral pain intervention; Coping skills; SMART design; Breast cancer; Pain

TL;DR:
Varying PCST doses led to pain reduction over time, and intervention sequences demonstrating the most durable decreases in pain reduction included PCST-Full.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: September 18, 2023

2023 journal article

Cost-Effectiveness Analysis Evaluating Delivery Strategies for Pain Coping Skills Training in Women With Breast Cancer

*JOURNAL OF PAIN*, *24*(9), 1712–1720.

author keywords: Cost-effectiveness; pain coping skills training; cancer pain; cognitive-behavioral therapy; behavioral pain management

TL;DR:
A cost-analysis of the delivery of Pain Coping Skills Training, a non-pharmacological intervention, to women with breast cancer and pain could potentially provide important cost-related information to healthcare providers and systems on the use of an efficacious and accessible non-medication strategy for pain management.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: October 23, 2023

2023 journal article

DYNAMIC PREDICTION OF RESIDUAL LIFE WITH LONGITUDINAL COVARIATES USING LONG SHORT-TERM MEMORY NETWORKS

*ANNALS OF APPLIED STATISTICS*, *17*(3), 2039–2058.

author keywords: Biomarker; dynamic prediction; electronic medical record; long short-term memory network; longitudinal data; MIMIC-III; neural network; residual life; sepsis; transformed mean residual life model

TL;DR:
It is demonstrated that the L STM-GLM and the LSTM-NN are useful tools for producing individualized, real-time predictions of RMRL that can help inform the treatment decisions of septic patients.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: November 6, 2023

2023 article

Interim monitoring of sequential multiple assignment randomized trials using partial information

Manschot, C., Laber, E., & Davidian, M. (2023, March 22). *BIOMETRICS*, Vol. 3.

author keywords: augmented inverse probability weighting; clinical trials; double robustness; dynamic treatment regimes; early stopping; group sequential analysis

TL;DR:
An estimator for the mean outcome under a given regime that gains efficiency by using partial information from enrolled participants regardless of their progression through treatment stages is proposed.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science; OpenAlex)

Sources: Web Of Science, NC State University Libraries

Added: April 4, 2023

2022 article

A general framework for subgroup detection via one-step value difference estimation

Johnson, D., Lu, W., & Davidian, M. (2022, August 2). *BIOMETRICS*, Vol. 8.

author keywords: exceptional law; optimal treatment rule; precision medicine; subgroup test; survival analysis; value function

TL;DR:
This work proposes a general framework for testing for the existence of a subgroup with enhanced treatment effects based on the difference of the estimated value functions under an estimated optimal treatment regime and a fixed regime that assigns everyone to the same treatment.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

16. Peace, Justice and Strong Institutions
(OpenAlex)

Sources: Web Of Science, NC State University Libraries

Added: August 15, 2022

2022 article

Group sequential methods for interim monitoring of randomized clinical trials with time-lagged outcome

Tsiatis, A. A., & Davidian, M. (2022, September 18). *STATISTICS IN MEDICINE*, Vol. 9.

author keywords: augmented inverse probability weighting; early stopping; influence function; proportion of information

MeSH headings : Humans; Randomized Controlled Trials as Topic; Odds Ratio; Research Design

TL;DR:
Treatment effect estimators that take account of censoring and incorporate covariate information at an interim analysis are derived using semiparametric theory and are demonstrated to lead to stronger evidence for early stopping than standard approaches.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: October 3, 2022

2022 journal article

Methods Based on Semiparametric Theory for Analysis in the Presence of Missing Data

*ANNUAL REVIEW OF STATISTICS AND ITS APPLICATION*, *9*, 167–196.

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: May 31, 2022

2022 journal article

Telehealth and racial disparities in colorectal cancer screening: A pilot study of how virtual clinician characteristics influence screening intentions

*JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE*, *6*(1).

author keywords: Cancer health disparities; colorectal cancer screening; telehealth; virtual human technology; precision prevention

TL;DR:
This study suggests that telehealth interventions that match Black patients with a Black VC can enhance perceptions of credibility and message relevance, which may then improve screening intentions, which is needed to reduce racial CRC screening disparities.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: May 23, 2022

2021 journal article

A Pilot Study Examining the Efficacy of Delivering Colorectal Cancer Screening Messages via Virtual Health Assistants

*American Journal of Preventive Medicine*, *61*(2), 251–255.

MeSH headings : Adult; Black or African American; Colorectal Neoplasms / diagnosis; Early Detection of Cancer; Humans; Mass Screening; Pilot Projects

TL;DR:
Animated virtual healthcare assistants were efficacious compared with the staticvirtual healthcare assistant and attention control conditions and warrants additional investigation in future studies given the potential for virtual healthcare assistant‒assisted interventions to promote colorectal cancer screening within guidelines.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

4. Quality Education
(OpenAlex)

Source: ORCID

Added: January 26, 2023

2021 article

Estimating vaccine efficacy over time after a randomized study is unblinded

Tsiatis, A. A., & Davidian, M. (2021, August 13). *BIOMETRICS*, Vol. 8.

author keywords: crossover; inverse probability weighting; potential outcomes; randomized phase 3 vaccine trial; waning vaccine efficacy

MeSH headings : COVID-19 / prevention & control; COVID-19 Vaccines; Humans; Pandemics / prevention & control; Randomized Controlled Trials as Topic; Research Design; SARS-CoV-2; Vaccine Efficacy

TL;DR:
This work focuses on the particular features of the Moderna trial and proposes a statistical framework based on a potential outcomes formulation within which methods for inference on potential waning of VE over time and estimation ofVE at any postvaccination time are developed.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science; OpenAlex)

Sources: Web Of Science, NC State University Libraries

Added: August 23, 2021

2021 article

Estimation of the odds ratio in a proportional odds model with censored time-lagged outcome in a randomized clinical trial

Tsiatis, A. A., Davidian, M., & Holloway, S. T. (2021, December 17). *BIOMETRICS*, Vol. 12.

author keywords: augmented inverse probability weighting; censored ordinal categorical outcome; covariate adjustment; COVID-19 treatment; estimating function; marked point process

TL;DR:
An estimator for the OR in a proportional odds model with censored, time‐lagged categorical outcome that incorporates additional baseline and time‐dependent covariate information and demonstrates that it can result in considerable gains in efficiency relative to simpler approaches is proposed.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: ORCID, Web Of Science, NC State University Libraries

Added: December 17, 2021

2021 article

Rejoinder: Estimating vaccine efficacy over time after a randomized study is unblinded

Tsiatis, A. A., & Davidian, M. (2021, August 22). *BIOMETRICS*, Vol. 8.

MeSH headings : Randomized Controlled Trials as Topic; Vaccine Efficacy

TL;DR:
Responding to the points they raise has enhanced the understanding of the area and the role of the work within it, and all note challenges posed by viral variants.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(OpenAlex)

Sources: Web Of Science, NC State University Libraries

Added: August 30, 2021

2020 book

Dynamic Treatment Regimes: Statistical Methods for Precision Medicine

In *CRC Press*.

Event: at Boca Raton, FL

Sources: ORCID, NC State University Libraries

Added: January 23, 2020

2019 review

Application of a sequential multiple assignment randomized trial (SMART) design in older patients with chronic lymphocytic leukemia

[Review of ]. *ANNALS OF ONCOLOGY*, *30*(4), 542–550.

author keywords: SMART; CLL; design strategies; adaptive interventions; randomized clinical trials

MeSH headings : Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Data Analysis; Disease Progression; Feasibility Studies; Humans; Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy; Leukemia, Lymphocytic, Chronic, B-Cell / mortality; Progression-Free Survival; Randomized Controlled Trials as Topic; Research Design; Sample Size

TL;DR:
SMART design strategies can be used in cancer clinical trials with adaptive interventions to identify optimal treatment strategies and are appropriate when comparing adaptive interventions, which are defined by an individual's sequence of treatment decisions and guided by intermediate outcomes.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: June 17, 2019

2018 journal article

Optimal two-stage dynamic treatment regimes from a classification perspective with censored survival data

*BIOMETRICS*, *74*(4), 1180–1192.

author keywords: Doubly robust; Inverse probability weighting; Optimal treatment regime; Sequential multiple assignment randomized trial; Support vector machine; Value search

MeSH headings : Acute Disease; Algorithms; Biometry / methods; Computer Simulation; Decision Support Techniques; Humans; Leukemia; Outcome Assessment, Health Care / methods; Outcome Assessment, Health Care / standards; Randomized Controlled Trials as Topic; Support Vector Machine; Survival Analysis

TL;DR:
A method for estimation of an optimal regime involving two decision points when the outcome of interest is a censored survival time is proposed, based on maximizing a locally efficient, doubly robust, augmented inverse probability weighted estimator for average outcome over a class of regimes.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

16. Peace, Justice and Strong Institutions
(OpenAlex)

Sources: Web Of Science, NC State University Libraries

Added: February 25, 2019

2018 entry reference

Q-Learning

UN Sustainable Development Goal Categories

16. Peace, Justice and Strong Institutions
(OpenAlex)

Sources: Crossref, NC State University Libraries

Added: January 19, 2020

2017 journal article

Biometrics, JABES and the International Biometric Society

*Journal of Agricultural, Biological and Environmental Statistics*, *22*(3), 221–223.

Sources: Crossref, NC State University Libraries

Added: January 13, 2020

2017 journal article

Dynamic treatment regimes, past, present, and future: A conversation with experts

*STATISTICAL METHODS IN MEDICAL RESEARCH*, *26*(4), 1605–1610.

author keywords: Optimal dynamic treatment regime; sequential multiple assignment randomized trial; mHealth; clinical trials; treatment sequence

MeSH headings : Datasets as Topic / trends; History, 20th Century; History, 21st Century; Humans; Precision Medicine / trends; Randomized Controlled Trials as Topic / history; Randomized Controlled Trials as Topic / methods

TL;DR:
Three leading researchers in the area of dynamic treatment regimes are asked to share their stories on how they became interested in this topic and their perspectives on the most important opportunities and challenges for the future.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2017 journal article

Interpretable Dynamic Treatment Regimes

*JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION*, *113*(524), 1541–1549.

author keywords: Decision lists; Interpretability; Precision medicine; Research-practice gap; Treatment regimes; Tree-based methods

TL;DR:
An estimator of an optimal treatment regime composed of a sequence of decision rules, each expressible as a list of “if-then” statements that can be presented as either a paragraph or as a simple flowchart that is immediately interpretable to domain experts is proposed.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: February 18, 2019

2017 journal article

Optimizing delivery of a behavioral pain intervention in cancer patients using a sequential multiple assignment randomized trial SMART

*Contemporary Clinical Trials*, *57*, 51–57.

author keywords: Smart; Novel trial designs; Breast cancer; Pain; Pain coping skills training; Symptom management

MeSH headings : Adaptation, Psychological; Adult; Breast Neoplasms / complications; Breast Neoplasms / therapy; Cognitive Behavioral Therapy / economics; Cognitive Behavioral Therapy / methods; Cost-Benefit Analysis; Female; Humans; Pain Management / economics; Pain Management / methods; Pain Measurement

TL;DR:
This is one of the first trials to use a novel design to evaluate symptom management in cancer patients and in chronic illness; if successful, it could serve as a model for future work with a wide range of chronic illnesses.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Crossref, NC State University Libraries, NC State University Libraries

Added: August 6, 2018

2017 journal article

Survival benefit of lung transplantation in the modern era of lung allocation

*Annals of the American Thoracic Society*, *14*(2), 172–181.

Source: NC State University Libraries

Added: August 6, 2018

2017 personal communication

The analysis of multivariate longitudinal data: A review: Response to letter of M. Gebregziabher

Verbeke, G., Fieuws, S., Molenberghs, G., & Davidian, M. (2017, February).

MeSH headings : Longitudinal Studies; Multivariate Analysis

TL;DR:
This research presents a novel and scalable approach to solving the challenge of integrating bioinformatics into the traditional e-commerce system.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2016 chapter

Dynamic treatment regimes

In S. L. George, X. Wang, & H. Pang (Eds.), *Cancer Clinical Trials: Current and Controversial Issues in Design and Analysis* (pp. 409–446). Boca Raton: Chapman & Hall/CRC Press.

Ed(s): S. George, X. Wang & H. Pang

Source: NC State University Libraries

Added: January 27, 2020

2016 article

Estimating optimal treatment regimes from a classification perspective (vol 1, pg 103, 2012)

*STAT*, Vol. 5, pp. 278–278.

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2016 journal article

On estimation of optimal treatment regimes for maximizing t -year survival probability

*Journal of the Royal Statistical Society: Series B (Statistical Methodology)*, *79*(4), 1165–1185.

author keywords: Inverse probability weighted estimation; Kaplan-Meier estimator; Optimal treatment regime; Personalized medicine; Survival probability; Value function

TL;DR:
This work proposes two non‐parametric estimators for the survival function of patients following a given treatment regime involving one or more decisions, i.e. the so‐called value, and introduces kernel smoothing within the estimator to improve performance.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science; OpenAlex)

Sources: Web Of Science, NC State University Libraries, Crossref

Added: August 6, 2018

2016 entry reference

Optimal Dynamic Treatment Regimes

Sources: Crossref, NC State University Libraries

Added: January 19, 2020

2016 article

Special Issue of Journal of Biopharmaceutical Statistics dedicated to 2016 Trends and Innovations in Clinical Trial Statistics (TICTS) Conference

*JOURNAL OF BIOPHARMACEUTICAL STATISTICS*, Vol. 27, pp. 357–357.

MeSH headings : Biological Products; Biopharmaceutics / statistics & numerical data; Clinical Trials as Topic / statistics & numerical data; Congresses as Topic

TL;DR:
The issue includes articles on missing data, multiple comparisons, sample size re-estimation, Bayesian methods and applications, strategies for estimating a homogeneous treatment effect in observational studies, use of modeling and simulations to improve decision making, and methods in oncology.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

2. Zero Hunger
(OpenAlex)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2016 journal article

Ten Simple Rules for Effective Statistical Practice

*PLOS Computational Biology*, *12*(6), e1004961.

Ed(s): F. Lewitter

MeSH headings : Algorithms; Computational Biology / methods; Computer Simulation; Data Accuracy; Data Interpretation, Statistical; Information Dissemination / methods; Models, Statistical

TL;DR:
This list of rules for putting together a Ten Simple Rules article related to statistics was developed with researchers in mind: researchers having some knowledge of statistics, possibly with one or more statisticians available in their building, or with a healthy do-it-yourself attitude and a handful of statistical packages on their laptops.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Crossref, NC State University Libraries, NC State University Libraries

Added: August 6, 2018

2015 journal article

A Placebo-Controlled, Prospective, Randomized Clinical Trial of Polyethylene Glycol and Methylprednisolone Sodium Succinate in Dogs with Intervertebral Disk Herniation

*JOURNAL OF VETERINARY INTERNAL MEDICINE*, *30*(1), 206–214.

Contributors: N. Olby^{ n} , A. Muguet-Chanoit^{ n}, J. Lim^{ n}, ^{ n} , C. Mariani^{ n} , A. Freeman^{*}, S. Platt ^{*}, J. Humphrey^{ n}

author keywords: Neuroprotection; Paraplegia; Secondary injury; Spinal cord injury

MeSH headings : Animals; Anti-Inflammatory Agents / administration & dosage; Anti-Inflammatory Agents / therapeutic use; Dog Diseases / drug therapy; Dogs; Female; Intervertebral Disc Displacement / drug therapy; Intervertebral Disc Displacement / veterinary; Male; Methylprednisolone Hemisuccinate / administration & dosage; Methylprednisolone Hemisuccinate / therapeutic use; Nociception / drug effects; Polyethylene Glycols / administration & dosage; Polyethylene Glycols / therapeutic use

TL;DR:
This clinical trial did not show a benefit of either MPSS or PEG in the treatment of acute, severe thoracolumbar IVDH when used as adjunctive medical treatment administered to dogs presenting within 24 hours of onset of paralysis.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science; OpenAlex)

Sources: Web Of Science, NC State University Libraries, ORCID

Added: August 6, 2018

2015 chapter

Chapter 9: Value search estimators for optimal dynamic treatment regimes

In *Adaptive Treatment Strategies in Practice* (pp. 135–155).

Sources: Crossref, NC State University Libraries

Added: January 22, 2020

2015 journal article

Properties of Estimators in Exponential Family Settings with Observationbased Stopping Rules

*Journal of Biometrics & Biostatistics*, *07*(01).

Sources: Crossref, NC State University Libraries

Added: January 19, 2020

2015 journal article

Using Decision Lists to Construct Interpretable and Parsimonious Treatment Regimes

*BIOMETRICS*, *71*(4), 895–904.

author keywords: Decision lists; Exploratory analyses; Interpretability; Personalized medicine; Treatment regimes

MeSH headings : Biometry / methods; Breast Neoplasms / drug therapy; Clinical Protocols; Clinical Trials as Topic / statistics & numerical data; Computer Simulation; Decision Trees; Depression / therapy; Evidence-Based Medicine / statistics & numerical data; Female; Humans; Models, Statistical; Precision Medicine / statistics & numerical data

TL;DR:
A simple, yet flexible class of treatment regimes whose members are representable as a short list of if–then statements are proposed, which are immediately interpretable and are therefore an appealing choice for broad application in practice.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2015 journal article

Using pilot data to size a two-arm randomized trial to find a nearly optimal personalized treatment strategy

*Statistics in Medicine*, *35*(8), 1245–1256.

author keywords: personalized medicine; sample size calculation; treatment regimes; nonregular asymptotics; projection confidence region

MeSH headings : Biostatistics; Computer Simulation; Confidence Intervals; Data Interpretation, Statistical; Evidence-Based Practice / statistics & numerical data; Female; Fertility; Humans; Male; Models, Statistical; Pilot Projects; Precision Medicine / statistics & numerical data; Pregnancy; Randomized Controlled Trials as Topic / statistics & numerical data; Regression Analysis; Sample Size

TL;DR:
This work offers a simple and robust method for powering a single stage, two‐armed randomized clinical trial when the primary aim is estimating the optimal single stage personalized treatment strategy.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science; OpenAlex)

Sources: Crossref, NC State University Libraries, Web Of Science

Added: August 6, 2018

2014 journal article

A robust method for estimating optimal treatment regimes

*Biometrics*, *71*, 271–273.

Sources: Crossref, NC State University Libraries

Added: January 27, 2020

2014 article

Combining Biomarkers to Optimize Patient Treatment Recommendations Discussions

Laber, E. B., Tsiatis, A. A., Davidian, M., & Holloway, S. T. (2014, September). *BIOMETRICS*, Vol. 70, pp. 707–710.

MeSH headings : Biomarkers, Tumor / blood; Biometry / methods; Breast Neoplasms / blood; Breast Neoplasms / therapy; Data Interpretation, Statistical; Female; Humans; Male; Outcome Assessment, Health Care / methods

TL;DR:
It is shown how the method of KJH can be used with existing policy-search methods to construct a treatment rule that is interpretable, logistically feasible, parsimonious, or otherwise appealing.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

4. Quality Education
(OpenAlex)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2014 journal article

Estimation After a Group Sequential Trial

*STATISTICS IN BIOSCIENCES*, *7*(2), 187–205.

author keywords: Exponential family; Frequentist inference; Generalized sample average; Joint modeling; Likelihood inference; Missing at random; Sample average

TL;DR:
It is shown that the ordinary sample average is a viable option for estimation following a group sequential trial, for a wide class of stopping rules and for random outcomes with a distribution in the exponential family, and it is consistent and asymptotically unbiased.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

10. Reduced Inequalities
(OpenAlex)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2014 chapter

Missing data methods: A semiparametric perspective

In G. Fitzmaurice, M. Kenward, G. Molenberghs, A. A. Tsiatis, & G. Verbeke (Eds.), *Handbook of Missing Data*. Boca Raton: Chapman & Hall/CRC Press.

Ed(s): G. Fitzmaurice, M. Kenward, G. Molenberghs, A. Tsiatis & G. Verbeke

Source: NC State University Libraries

Added: January 27, 2020

2014 journal article

Publishing without perishing and other career advice

*Past, Present, and Future of Statistical Science*, 581–591.

Source: NC State University Libraries

Added: August 6, 2018

2014 journal article

Q- and A-Learning Methods for Estimating Optimal Dynamic Treatment Regimes

*STATISTICAL SCIENCE*, *29*(4), 640–661.

author keywords: Advantage learning; bias-variance trade-off; model misspecification; personalized medicine; potential outcomes; sequential decision-making

TL;DR:
This work provides a detailed account of Q- and A-learning methods, study their performance, and illustrate them using data from a depression study.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2014 chapter

Research Methods for Clinical Trials in Personalized Medicine: A Systematic Review

In *Lost in Translation* (pp. 659–684).

Sources: Crossref, NC State University Libraries

Added: January 22, 2020

2014 journal article

SNP_NLMM: A SAS Macro to Implement a Flexible Random Effects Density for Generalized Linear and Nonlinear Mixed Models

*Journal of Statistical Software*, *56*(Code Snippet 2).

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(OpenAlex)

Sources: Crossref, NC State University Libraries

Added: January 22, 2020

2014 book

Sources: Crossref, NC State University Libraries

Added: August 6, 2018

2013 journal article

Assessing the Causal Effect of Organ Transplantation on the Distribution of Residual Lifetime

*BIOMETRICS*, *69*(4), 820–829.

author keywords: Causal inference; G-estimation; Lung transplantation; Martingale theory; Structural nested failure time models

MeSH headings : Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Causality; Data Interpretation, Statistical; Humans; Internationality; Life Expectancy; Lung Diseases / mortality; Lung Diseases / surgery; Lung Transplantation / mortality; Middle Aged; Outcome Assessment, Health Care / methods; Survival Rate; Young Adult

TL;DR:
A version of G‐estimation is developed that accounts for the fact that treatment assignment is not independent across individuals to estimate the parameters of a structural nested failure time model and leads to valid inference of the effect of transplantation on the distribution of residual lifetime.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2013 chapter

Bias Reduction in Logistic Regression with Estimated Variance Predictors

In *ISS-2012 Proceedings Volume On Longitudinal Data Analysis Subject to Measurement Errors, Missing Values, and/or Outliers* (pp. 33–51).

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(OpenAlex)

Sources: Crossref, NC State University Libraries

Added: March 13, 2020

2013 journal article

Building the Biostatistics Pipeline: Summer Institutes for Training in Biostatistics (SIBS)

*CHANCE*, *26*(1), 4–9.

Sources: Crossref, NC State University Libraries

Added: January 23, 2020

2013 personal communication

Collaboration To Meet the Statistical Needs in the Chemistry Curriculum

Davidian, M., & Kutal, C. (2014, January).

UN Sustainable Development Goal Categories

4. Quality Education
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2013 journal article

Moment adjusted imputation for multivariate measurement error data with applications to logistic regression

*COMPUTATIONAL STATISTICS & DATA ANALYSIS*, *67*, 15–24.

author keywords: Moment adjusted imputation; Multivariate measurement error; Logistic regression; Regression calibration

TL;DR:
Moment Adjusted Imputation is method for measurement error in a scalar latent variable that is easy to implement and performs well in a variety of settings and the extension of MAI to the setting of multivariate latent variables involves unique challenges.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2013 journal article

Robust estimation of optimal dynamic treatment regimes for sequential treatment decisions

*BIOMETRIKA*, *100*(3), 681–694.

author keywords: A-learning; Double robustness; Outcome regression; Propensity score; Q-learning

TL;DR:
This work proposes an alternative to Q- and A-learning that maximizes a doubly robust augmented inverse probability weighted estimator for population mean outcome over a restricted class of regimes.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries, ORCID

Added: August 6, 2018

2013 article

The International Year of Statistics: A Celebration and A Call to Action

Davidian, M. (2013, December). *JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION*, Vol. 108, pp. 1141–1146.

UN Sustainable Development Goal Categories

12. Responsible Consumption and Production
(Web of Science)

16. Peace, Justice and Strong Institutions
(OpenAlex)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2012 journal article

A Robust Method for Estimating Optimal Treatment Regimes

*BIOMETRICS*, *68*(4), 1010–1018.

author keywords: Doubly robust estimator; Inverse probability weighting; Outcome regression; Personalized medicine; Potential outcomes; Propensity score

MeSH headings : Breast Neoplasms / epidemiology; Breast Neoplasms / therapy; Clinical Trials as Topic / methods; Computer Simulation; Decision Support Systems, Clinical; Female; Humans; Models, Statistical; Outcome Assessment, Health Care / methods; Prevalence; Regression Analysis; Treatment Outcome

TL;DR:
A doubly robust augmented inverse probability weighted estimator is used for finding the optimal regime within a class of regimes by finding the regime that optimizes an estimator of overall population mean outcome.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science; OpenAlex)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2012 journal article

Estimating optimal treatment regimes from a classification perspective

*Stat*, *1*(1), 103–114.

author keywords: classification; doubly robust estimator; inverse probability weighting; personalized medicine; potential outcomes; propensity score

TL;DR:
This work proposes a novel and general framework that transforms the problem of estimating an optimal treatment regime into a classification problem wherein the optimal classifier corresponds to the optimalreatment regime.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science; OpenAlex)

Sources: ORCID, Crossref, NC State University Libraries

Added: January 23, 2020

2012 journal article

On random sample size, ignorability, ancillarity, completeness, separability, and degeneracy: Sequential trials, random sample sizes, and missing data

*STATISTICAL METHODS IN MEDICAL RESEARCH*, *23*(1), 11–41.

author keywords: Frequentist inference; generalized sample average; informative cluster size; joint modeling; likelihood inference; missing at random; random cluster size

MeSH headings : Likelihood Functions; Models, Statistical; Probability; Sample Size

TL;DR:
The aim is to place various related examples into a single framework derived from the joint modeling of the outcomes and sampling process and so derive generic results that in turn provide insight, and in some cases practical consequences, for different settings.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2012 journal article

The analysis of multivariate longitudinal data: A review

*STATISTICAL METHODS IN MEDICAL RESEARCH*, *23*(1), 42–59.

author keywords: Mixed models; random effects; shared parameters; marginal models; conditional models; latent variables

MeSH headings : Hearing; Humans; Longitudinal Studies; Models, Statistical; Multivariate Analysis

TL;DR:
This article will present a review of the many approaches proposed in the statistical literature, and four main model families will be presented, discussed and compared.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2012 journal article

Variable selection for covariate-adjusted semiparametric inference in randomized clinical trials

*STATISTICS IN MEDICINE*, *31*(29), 3789–3804.

author keywords: covariate adjustment; false selection rate control; oracle property; semiparametric treatment effect estimation; shrinkage methods; variable selection

MeSH headings : Algorithms; Humans; Models, Statistical; Randomized Controlled Trials as Topic / statistics & numerical data; Research Design; Selection Bias; Statistics, Nonparametric

TL;DR:
It is demonstrated that objective variable selection techniques combined with a semiparametric framework can identify key variables and lead to unbiased and efficient inference on the treatment effect and show its superior performance relative to that of existing methods.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2012 article

Why Statistics?

Davidian, M., & Louis, T. A. (2012, April 6). *SCIENCE*, Vol. 336, pp. 12–12.

UN Sustainable Development Goal Categories

12. Responsible Consumption and Production
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2011 journal article

A Moment-Adjusted Imputation Method for Measurement Error Models

*BIOMETRICS*, *67*(4), 1461–1470.

author keywords: Conditional score; Measurement error; Nonlinear models; Regression calibration

MeSH headings : Algorithms; Blood Pressure Determination / methods; Computer Simulation; Data Interpretation, Statistical; Heart Failure / diagnosis; Heart Failure / epidemiology; Humans; Models, Statistical; Reproducibility of Results; Sensitivity and Specificity

TL;DR:
An imputation approach called moment‐adjusted imputation that is flexible and relatively automatic that can be used to adjust a variety of analyses quickly, and it performs well under a broad range of circumstances is proposed.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2011 journal article

Connections between survey calibration estimators and semiparametric models for incomplete data discussion

*International Statistical Review*, *79*(2), 221–223.

Source: NC State University Libraries

Added: August 6, 2018

2011 journal article

Doubly Robust Estimation of Causal Effects

*AMERICAN JOURNAL OF EPIDEMIOLOGY*, *173*(7), 761–767.

author keywords: causal inference; epidemiologic methods; propensity score

MeSH headings : Causality; Computer Simulation; Confidence Intervals; Confounding Factors, Epidemiologic; Epidemiologic Methods; Humans; Likelihood Functions; Models, Statistical; Monte Carlo Method; Propensity Score; Regression Analysis

TL;DR:
The authors present a conceptual overview of doubly robust estimation, a simple worked example, results from a simulation study examining performance of estimated and bootstrapped standard errors, and a discussion of the potential advantages and limitations of this method.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2011 journal article

Mixed model analysis of censored longitudinal data with flexible random-effects density

*BIOSTATISTICS*, *13*(1), 61–73.

author keywords: Censoring; HCV; HIV; Limit of quantification; Longitudinal data; Random effects

MeSH headings : Antiviral Agents / therapeutic use; Bias; Biostatistics; Data Interpretation, Statistical; Hepatitis C / drug therapy; Hepatitis C / virology; Humans; Interferon-alpha / therapeutic use; Linear Models; Longitudinal Studies; Models, Statistical; Statistics, Nonparametric; Viral Load / drug effects

TL;DR:
A mixed model framework for censored longitudinal data in which the random effects are represented by the flexible seminonparametric density is developed andSimulations show that this approach can lead to reduction in bias and increase in efficiency relative to assuming Gaussian random effects.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2011 journal article

Timing of HAART initiation and clinical outcomes in human immunodeficiency virus type 1 seroconverters

*Archives of Internal Medicine*, *171*(17), 1560–1569.

Source: NC State University Libraries

Added: August 6, 2018

2010 journal article

Demographic and Historical Findings, Including Exposure to Environmental Tobacco Smoke, in Dogs with Chronic Cough

*JOURNAL OF VETERINARY INTERNAL MEDICINE*, *24*(4), 825–831.

author keywords: Bronchitis; Environmental tobacco smoke; Respiratory tract; Tracheobronchomalacia

MeSH headings : Air Pollution, Indoor / adverse effects; Animals; Chronic Disease; Cough / chemically induced; Cough / veterinary; Dog Diseases / chemically induced; Dog Diseases / diagnosis; Dogs; Female; Male; Risk Factors; Tobacco Smoke Pollution / adverse effects

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science; OpenAlex)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2010 chapter

Doubly robust estimation of treatment effects

In D. Faries, A. Leon, J. M. Haro, & R. Obenchain (Eds.), *Analysis of Observational Health-Care Data Using SAS*. Cary, NC: SAS Press.

Ed(s): D. Faries, A. Leon, J. Haro & R. Obenchain

Source: NC State University Libraries

Added: January 27, 2020

2010 chapter

Experimental Statistics for biological sciences

In H. Bang, X. K. Zhou, H. L. Van Epps, & M. Mazumdar (Eds.), *Statistical Methods in Molecular Biology* (pp. 3–104). New York: Springer (Humana Press).

Ed(s): H. Bang, X. Zhou, H. Van Epps & M. Mazumdar

Source: NC State University Libraries

Added: January 27, 2020

2010 journal article

Improved Doubly Robust Estimation When Data Are Monotonely Coarsened, with Application to Longitudinal Studies with Dropout

*BIOMETRICS*, *67*(2), 536–545.

author keywords: Coarsening at random; Discrete hazard; Dropout; Longitudinal data; Missing at random

MeSH headings : Acquired Immunodeficiency Syndrome; Biometry / methods; Computer Simulation; Humans; Longitudinal Studies; Models, Statistical; Statistical Distributions

TL;DR:
This work proposes a DR estimator applicable in general monotone coarsening problems that achieves comparable or improved performance relative to existing DR methods, which is demonstrated via simulation studies and by application to data from an AIDS clinical trial.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2010 journal article

Inference on treatment effects from a randomized clinical trial in the presence of premature treatment discontinuation: the SYNERGY trial

*BIOSTATISTICS*, *12*(2), 258–269.

author keywords: Dynamic treatment regime; Inverse probability weighting; Potential outcomes; Proportional hazards model

MeSH headings : Acute Coronary Syndrome / drug therapy; Algorithms; Computer Simulation; Endpoint Determination; Enoxaparin / administration & dosage; Enoxaparin / adverse effects; Enoxaparin / therapeutic use; Hemorrhage / etiology; Heparin / administration & dosage; Heparin / adverse effects; Heparin / therapeutic use; Humans; Intention to Treat Analysis; Models, Statistical; Monte Carlo Method; Mortality; Multicenter Studies as Topic; Probability; Proportional Hazards Models; Randomized Controlled Trials as Topic / methods; Survival Analysis; Treatment Outcome; Withholding Treatment / statistics & numerical data

TL;DR:
The Superior Yield of the New Strategy of Enoxaparin, Revascularization, and GlYcoprotein IIb/IIIa inhibitors (SYNERGY) was a randomized, open-label, multicenter clinical trial comparing 2 anticoagulant drugs on the basis of time-to-event endpoints.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science; OpenAlex)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2009 chapter

An Inverse Problem Statistical Methodology Summary

In *Mathematical and Statistical Estimation Approaches in Epidemiology* (pp. 249–302).

Sources: Crossref, NC State University Libraries

Added: January 23, 2020

2009 journal article

Gene-Trait Similarity Regression for Multimarker-Based Association Analysis

*Biometrics*, *65*(3), 822–832.

MeSH headings : Chromosome Mapping / methods; Computer Simulation; Genetic Linkage / genetics; Genetic Markers / genetics; Haplotypes / genetics; Humans; Models, Genetic; Models, Statistical; Quantitative Trait Loci / genetics; Regression Analysis

TL;DR:
The proposed similarity‐based regression method to detect associations between traits and multimarker genotypes allows for covariates, uses phase‐independent similarity measures to bypass the needs to impute phase information, and is applicable to traits of general types.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: NC State University Libraries, NC State University Libraries, Crossref

Added: August 6, 2018

2009 journal article

Improving efficiency and robustness of the doubly robust estimator for a population mean with incomplete data

*BIOMETRIKA*, *96*(3), 723–734.

author keywords: Causal inference; Enhanced propensity score model; Missing at random; No unmeasured confounders; Outcome regression

TL;DR:
This work proposes alternative doubly robust estimators that achieve comparable or improved performance relative to existing methods, even with some estimated propensity scores close to zero.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2009 journal article

Latent-Model Robustness in Joint Models for a Primary Endpoint and a Longitudinal Process

*BIOMETRICS*, *65*(3), 719–727.

author keywords: Censoring; Random effect; Remeasurement method; SIMEX

MeSH headings : Biometry / methods; Clinical Trials as Topic; Computer Simulation; Data Interpretation, Statistical; Effect Modifier, Epidemiologic; Endpoint Determination / methods; Longitudinal Studies; Models, Statistical; Regression Analysis

TL;DR:
Methods to diagnose random effect model misspecification of the type that leads to biased inference on joint models are presented and illustrated via application to simulated data.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science; OpenAlex)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2009 journal article

Nonlinear Models for Longitudinal Data

*AMERICAN STATISTICIAN*, *63*(4), 378–388.

author keywords: Conditional model; Marginal model; Random-effects model; Serial correlation; Transition model

TL;DR:
All three main modeling families, marginal models, random-effects models, and conditional models are considered, exemplify their great flexibility and relative ease of use, and apply them to a simple but illustrative set of data on tree circumference growth of orange trees.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2008 journal article

"Smooth" semiparametric regression analysis for arbitrarily censored time-to-event data

*BIOMETRICS*, *64*(2), 567–576.

author keywords: accelerated failure time model; heteroscedasticity; information criteria; interval censoring; proportional hazards model; proportional odds model; seminonparametric (SNP) density; time-dependent covariates

MeSH headings : Biometry / methods; Computer Simulation; Data Interpretation, Statistical; Models, Statistical; Regression Analysis; Statistics, Nonparametric

TL;DR:
A general framework for regression analysis of time-to-event data subject to arbitrary patterns of censoring is proposed, which allows popular models, such as the proportional hazards, proportional odds, and accelerated failure time models, to be placed in a common framework and provides a principled basis for choosing among them.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2008 journal article

'Smooth' inference for survival functions with arbitrarily censored data

*Statistics in Medicine*, *27*(26), 5421–5439.

MeSH headings : Clinical Trials as Topic / methods; Computer Simulation; Data Interpretation, Statistical; Disease Progression; Endpoint Determination; Humans; Likelihood Functions; Statistics, Nonparametric; Survival Analysis

TL;DR:
The method is predicated on the mild assumption that the distribution of the random variable has a density that lies in a class of 'smooth' densities whose elements can be represented by an infinite Hermite series, and can result in gains in efficiency over traditional nonparametric methods.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: NC State University Libraries, NC State University Libraries

Added: August 6, 2018

2008 journal article

A model for HCMV infection in immunosuppressed patients

*MATHEMATICAL AND COMPUTER MODELLING*, *49*(7-8), 1653–1663.

author keywords: HCMV; CMV; Herpes; Transplantation; Mathematical model; Immunosuppression

TL;DR:
Simulations with the approximated parameter values demonstrates that the model is capable of describing primary, latent, and secondary (reactivated) HCMV infection.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science; OpenAlex)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2008 journal article

Improving efficiency of inferences in randomized clinical trials using auxiliary covariates

*BIOMETRICS*, *64*(3), 707–715.

author keywords: covariate adjustment; hypothesis test; k-arm trial; Kruskal-Wallis test; log odds ratio; longitudinal data; semiparametric theory

MeSH headings : Acquired Immunodeficiency Syndrome / drug therapy; Analysis of Variance; Angina, Unstable / blood; Angina, Unstable / drug therapy; Anti-HIV Agents / therapeutic use; Anticoagulants / therapeutic use; Biometry / methods; Humans; Linear Models; Logistic Models; Models, Statistical; Monte Carlo Method; Odds Ratio; Platelet Glycoprotein GPIIb-IIIa Complex / metabolism; Randomized Controlled Trials as Topic / statistics & numerical data; Treatment Outcome

TL;DR:
Taking a semiparametric theory perspective, this work proposes a broadly applicable approach to adjustment for auxiliary covariates to achieve more efficient estimators and tests for treatment parameters in the analysis of randomized clinical trials.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2008 chapter

Joint models for longitudinal data

In *Chapman & Hall/CRC Handbooks of Modern Statistical Methods* (pp. 319–326).

Sources: Crossref, NC State University Libraries

Added: January 23, 2020

2008 book

Source: Crossref

Added: January 23, 2020

2008 book

Longitudinal Data Analysis

In *Chapman & Hall/CRC, Taylor & Francis Group*. Boca Raton, FL: Chapman & Hall/CRC.

Event: at Boca Raton, FL

Source: ORCID

Added: March 29, 2023

2008 journal article

Modelling HIV immune response and validation with clinical data

*Journal of Biological Dynamics*, *2*(4), 357–385.

MeSH headings : CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / virology; HIV / immunology; HIV Antigens / immunology; HIV Infections / drug therapy; HIV Infections / immunology; HIV Infections / virology; Humans; Immunity / immunology; Models, Immunological; Reproducibility of Results; Viral Load / immunology; Viremia / immunology; Virus Activation / immunology

TL;DR:
This more biologically detailed model can exhibit the phenomenon of transient viremia experienced by some patients on therapy with viral load levels suppressed below the detection limit, and it is shown that treatment to move from a high viral load equilibrium state to an equilibrium state with a lower viral load is not possible for these patients.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(OpenAlex)

Sources: Crossref, NC State University Libraries

Added: January 23, 2020

2008 chapter

Non-linear mixed-effects models

In *Chapman & Hall/CRC Handbooks of Modern Statistical Methods* (pp. 107–141).

Sources: Crossref, NC State University Libraries

Added: January 19, 2020

2007 journal article

Comment: Demystifying Double Robustness: A Comparison of Alternative Strategies for Estimating a Population Mean from Incomplete Data

*Statistical Science*, *22*(4), 569–573.

Sources: Crossref, NC State University Libraries

Added: January 24, 2020

2007 article

Covariate adjustment for two-sample treatment comparisons in randomized clinical trials: A principled yet flexible approach

Tsiatis, A. A., Davidian, M., Zhang, M., & Lu, X. (2008, October 15). *STATISTICS IN MEDICINE*, Vol. 27, pp. 4658–4677.

author keywords: baseline variables; clinical trials; covariate adjustment; efficiency; semiparametric theory; variable selection

MeSH headings : Algorithms; Data Interpretation, Statistical; Humans; Randomized Controlled Trials as Topic / statistics & numerical data; Sampling Studies; Statistics, Nonparametric; Treatment Outcome

TL;DR:
App appealing to the theory of semiparametrics is led naturally to a characterization of all treatment effect estimators and to principled, practically feasible methods for covariate adjustment that yield the desired gains in efficiency and that allow covariate relationships to be identified and exploited while circumventing the usual concerns.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2007 journal article

Estimation and prediction with HIV-treatment interruption data

*BULLETIN OF MATHEMATICAL BIOLOGY*, *69*(2), 563–584.

author keywords: HIV models; treatment interruptions; censored data; parameter estimation; prediction

MeSH headings : Antiretroviral Therapy, Highly Active / methods; CD4 Lymphocyte Count; Cohort Studies; Data Interpretation, Statistical; Drug Administration Schedule; HIV Infections / drug therapy; HIV Infections / immunology; HIV-1; Humans; Longitudinal Studies; Models, Biological; Predictive Value of Tests; Viral Load

TL;DR:
This work uses a nonlinear dynamical mathematical model in attempts to fit individual patient data for HIV patients undergoing treatment interruptions using a statistically-based censored data method and inverse problem techniques to estimate dynamic parameters.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2007 journal article

Likelihood and pseudo-likelihood methods for semiparametric joint models for a primary endpoint and longitudinal data

*Computational Statistics & Data Analysis*, *51*(12), 5776–5790.

author keywords: conditional score; generalized linear model; mixed effects model; pseudo-likelihood; seminonparametric density

TL;DR:
A semiparametric joint model is considered that makes only mild assumptions on this distribution and likelihood-based inference on the association and distribution is developed, which offers improved performance relative to existing methods that is insensitive to the true random effects distribution.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries, Crossref

Added: August 6, 2018

2007 journal article

Using mathematical modeling and control to develop structured treatment interruption strategies for HIV infection

*DRUG AND ALCOHOL DEPENDENCE*, *88*, S41–S51.

author keywords: STI; CD4; HIV dynamics; drug resistance; viral load

MeSH headings : CD4 Antigens / immunology; HIV Infections / drug therapy; HIV Infections / immunology; Humans; Models, Theoretical

TL;DR:
It is argued that the most promising STI strategies are adaptive treatment strategies, which involve cycles of treatment withdrawal and re-initiation and that, when such mathematical representations of processes underlying a disease or disorder are available, they can be an important tool for suggesting adaptive treatment Strategies for clinical study.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science; OpenAlex)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2006 entry reference

Dose Calibration

Sources: Crossref, NC State University Libraries

Added: January 24, 2020

2006 journal article

Latent-model robustness in structural measurement error models

*BIOMETRIKA*, *93*(1), 53–64.

author keywords: bias; latent variable; measurement error; remeasurement method; simulation extrapolation; structural modelling

TL;DR:
Methods for diagnosing the effects of model misspecification of the true-predictor distribution in structural measurement error models and practical techniques for examining the adequacy of an assumed latent predictor model are presented.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science; OpenAlex)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2006 journal article

Smoothing spline-based score tests for proportional hazards models

*BIOMETRICS*, *62*(3), 803–812.

author keywords: Cox model; penalized partial likelihood; smoothing parameter; variance component

MeSH headings : Analysis of Variance; Biometry / methods; Breast Neoplasms / drug therapy; Breast Neoplasms / metabolism; Clinical Trials as Topic / statistics & numerical data; Female; Humans; Likelihood Functions; Menopause; Proportional Hazards Models; Receptors, Estrogen / metabolism

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2005 entry reference

Biometrics

Sources: Crossref, NC State University Libraries

Added: January 24, 2020

2005 journal article

HIV dynamics: Modeling, data analysis, and optimal treatment protocols

*JOURNAL OF COMPUTATIONAL AND APPLIED MATHEMATICS*, *184*(1), 10–49.

author keywords: HIV models; parameter estimation; data and model reduction; structured treatment interruptions; optimal control

TL;DR:
An overview of some concepts and methodologies useful in modeling HIV pathogenesis including parameter estimation, data reduction and representation, and optimal control relative to STI are presented.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science; OpenAlex)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2005 journal article

Semiparametric estimation of treatment effect in a pretest-posttest study with missing data

*Statistical Science*, *20*(3), 261–282.

Source: NC State University Libraries

Added: August 6, 2018

2005 article

Statistical issues arising in the Women's Health Initiative - Discussion

Tsiatis, A. A., & Davidian, M. (2005, December). *BIOMETRICS*, Vol. 61, pp. 933–935.

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

5. Gender Equality
(OpenAlex)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2005 journal article

Surgeons? Economic Profiles: Can We Get the ?Right? Answers?

*Journal of Medical Systems*, *29*(2), 111–124.

MeSH headings : Aged; Benchmarking / methods; Cardiology Service, Hospital / economics; Cohort Studies; Coronary Artery Bypass / economics; Coronary Artery Bypass / mortality; Costs and Cost Analysis; Data Interpretation, Statistical; Female; Health Services Research / methods; Hospital Bed Capacity, 500 and over; Humans; Male; Middle Aged; Models, Economic; Practice Patterns, Physicians' / economics; Reproducibility of Results; Risk; Treatment Outcome

TL;DR:
It is found that profiles reporting unadjusted average surgeon costs may incorrectly identify high- and low-cost outliers, demonstrating the need for hospitals to reexamine their economic profiling methods.
(via Semantic Scholar)

Sources: Crossref, NC State University Libraries

Added: January 24, 2020

2004 journal article

Conditional estimation for generalized linear models when covariates are subject-specific parameters in a mixed model for longitudinal measurements

*Biometrics*, *60*(1), 07-.

Source: NC State University Libraries

Added: August 6, 2018

2004 journal article

Differential Treatment Benefit of Platelet Glycoprotein IIb/IIIa Inhibition With Percutaneous Coronary Intervention Versus Medical Therapy for Acute Coronary Syndromes

*Circulation*, *109*(5), 641–646.

author keywords: trials; glycoproteins; coronary disease

MeSH headings : Acute Disease; Aged; Combined Modality Therapy; Coronary Disease / drug therapy; Coronary Disease / surgery; Female; Humans; Male; Middle Aged; Myocardial Revascularization; Patient Selection; Platelet Glycoprotein GPIIb-IIIa Complex / antagonists & inhibitors; Randomized Controlled Trials as Topic; Research Design; Syndrome; Treatment Outcome

TL;DR:
Clinical-practice decisions and practice guidelines should be based on overall trial results and not analyses of post-randomization subgroups, based primarily on inappropriate subgroup analyses performed across the glycoprotein IIb/IIIa inhibitor trials.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science; OpenAlex)

Sources: Crossref, NC State University Libraries, Web Of Science

Added: August 6, 2018

2004 journal article

Discussion of nonparametric and semiparametric regression

*Statistica Sinica*, *14*(3), 615–629.

Source: NC State University Libraries

Added: August 6, 2018

2004 journal article

Emerging issues in longitudinal and functional data analysis - Introduction

*Statistica Sinica*, *14*(3), 613–614.

Source: NC State University Libraries

Added: August 6, 2018

2004 journal article

Growth, mortality, and hatchdate distributions of larval and juvenile spotted seatrout (Cynoscion nebulosus) in Florida Bay, Everglades National Park

*Fishery Bulletin (Washington, D.C.)*, *102*(1), 142–155.

Source: NC State University Libraries

Added: August 6, 2018

2004 journal article

Joint modeling of longitudinal and time-to-event data: An overview

*Statistica Sinica*, *14*(3), 809–834. http://www.jstor.org/stable/24307417

Sources: NC State University Libraries, ORCID

Added: August 6, 2018

2004 journal article

Likelihood and conditional likelihood inference for generalized additive mixed models for clustered data

*JOURNAL OF MULTIVARIATE ANALYSIS*, *91*(1), 90–106.

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2004 chapter

Linear mixed effects models with flexible generalized skew-elliptical random effects

In *Skew-elliptical distibutions and their applications: A journey beyond normality*. Boca Raton, FL: Chapman & Hall/CRC.

Source: NC State University Libraries

Added: August 6, 2018

2004 journal article

Marginal structural models for analyzing causal effects of time-dependent treatments: An application in perinatal epidemiology

*AMERICAN JOURNAL OF EPIDEMIOLOGY*, *159*(10), 926–934.

author keywords: causality; confounding factors (epidemiology); epidemiologic methods; longitudinal studies; models, structural

MeSH headings : Adult; Anemia / diet therapy; Anemia / epidemiology; Anemia / prevention & control; Causality; Confounding Factors, Epidemiologic; Dietary Supplements; Epidemiologic Research Design; Female; Humans; Iron / administration & dosage; Logistic Models; Models, Statistical; North Carolina / epidemiology; Pregnancy; Pregnancy Complications, Hematologic / diet therapy; Pregnancy Complications, Hematologic / epidemiology; Pregnancy Complications, Hematologic / prevention & control; Random Allocation; Time Factors

TL;DR:
The objective of this paper is to illustrate the fitting of an MSM for the causal effect of iron supplement use during pregnancy (time-varying treatment) on odds of anemia at delivery in the presence of time-dependent confounding.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science; OpenAlex)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2004 journal article

Stratification and weighting via the propensity score in estimation of causal treatment effects: a comparative study

*STATISTICS IN MEDICINE*, *23*(19), 2937–2960.

author keywords: covariate balance; double robustness; inverse-probability-of-treatment-weighted-estimator; observational data

MeSH headings : Computer Simulation; Data Interpretation, Statistical; Humans; Monte Carlo Method; Regression Analysis; Treatment Outcome

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2003 journal article

Nonlinear models for repeated measurement data: An overview and update

*JOURNAL OF AGRICULTURAL BIOLOGICAL AND ENVIRONMENTAL STATISTICS*, *8*(4), 387–419.

author keywords: hierarchical model; inter-individual variation; intra-individual variation; nonlinear mixed effects model; random effects; serial correlation; subject-specific

TL;DR:
An overview of the formulation, interpretation, and implementation of nonlinear mixed effects models and surveys recent advances and applications is presented.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2003 journal article

Robust two-stage approach to repeated measurements analysis of chronic ozone exposure in rats

*JOURNAL OF AGRICULTURAL BIOLOGICAL AND ENVIRONMENTAL STATISTICS*, *8*(4), 438–454.

author keywords: ANOVA; hierarchical nonlinear model; M-estimation; Michaelis-Menten; mixed effects; outlier

TL;DR:
A robust two-stage approach is used to reanalyze the repeated measurements from an experiment of airway responsiveness in rats randomized to long-term exposure at four ozone doses, finding the true effect of chronic ozone exposure may be masked by a few rats which exert undue influence on the population estimates in a nonrobust analysis.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2003 journal article

Semiparametric estimation of treatment effect in a pretest-posttest study

*BIOMETRICS*, *59*(4), 1046–1055.

author keywords: analysis of covariance; counterfactuals; influence function; inverse probability weighting; semiparametric model; t-test

MeSH headings : Antiviral Agents / therapeutic use; Biometry / methods; CD4 Lymphocyte Count; Clinical Trials as Topic; Computer Simulation; HIV Infections / drug therapy; Humans; Models, Statistical; Randomized Controlled Trials as Topic; Statistics, Nonparametric

TL;DR:
This work exploits recent developments in the literature on missing data and causal inference to derive the class of all consistent treatment effect estimators, identify the most efficient such estimator, and outline strategies for implementation of estimators that may improve on popular methods.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science; OpenAlex)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2002 journal article

A Monte Carlo EM algorithm for generalized linear mixed models with flexible random effects distribution.

*Biostatistics (Oxford, England)*, *3*(3), 347–360.

author keywords: correlated data; rejection sampling; seminonparametric density; semiparametric mixed model

TL;DR:
A Monte Carlo EM algorithm using a rejection sampling scheme to estimate the fixed parameters of the linear predictor, variance components and the SNP density is proposed.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: ORCID, NC State University Libraries, NC State University Libraries

Added: August 6, 2018

2002 journal article

A semiparametric likelihood approach to joint modeling of longitudinal and time-to-event data

*BIOMETRICS*, *58*(4), 742–753.

author keywords: informative censoring; mixed model; proportional hazards; SNP density; survival

MeSH headings : Anti-HIV Agents / therapeutic use; Biometry / methods; Computer Simulation; Disease Progression; HIV Infections / drug therapy; Humans; Likelihood Functions; Longitudinal Studies; Monte Carlo Method; Proportional Hazards Models; Randomized Controlled Trials as Topic / methods

TL;DR:
This work proposes a likelihood-based approach that requires only the assumption that the random effects have a smooth density, and implementation via the EM algorithm is described, and performance and the benefits for uncovering noteworthy features are illustrated.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science; OpenAlex)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2002 journal article

An estimator for the proportional hazards model with multiple longitudinal covariates measured with error

*Biostatistics (Oxford, England)*, *3*(4), 511–528.

Source: NC State University Libraries

Added: August 6, 2018

2002 chapter

Constrained four parameter logistic model

In *Developments in Biologicals*: *Vol.* *107*. *The Design and Analysis of Potency Assays for Biotechnology Products* (pp. 71–76). Basel: Karger.

Source: NC State University Libraries

Added: September 27, 2020

2002 journal article

Estimation of survival distributions of treatment policies in two-stage randomization designs in clinical trials

*BIOMETRICS*, *58*(1), 48–57.

author keywords: induction therapy; intent to treat; inverse weighting; maintenance therapy; potential outcomes; survival analysis

MeSH headings : Aged; Computer Simulation; Granulocyte-Macrophage Colony-Stimulating Factor / therapeutic use; Humans; Leukemia, Myeloid, Acute / drug therapy; Models, Statistical; Randomized Controlled Trials as Topic / methods; Survival Analysis; Treatment Outcome

TL;DR:
It is proposed consistent estimators for the survival distribution and mean restricted survival time for each treatment policy in such two‐stage studies and derive large‐sample properties.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science; OpenAlex)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2002 journal article

Multiple imputation methods for testing treatment differences in survival distributions with missing cause of failure

*Biometrika*, *89*(1), 238–244.

Source: NC State University Libraries

Added: August 6, 2018

2002 journal article

Randomized COMparison of platelet inhibition with abciximab, TiRofiban and eptifibatide during percutaneous coronary intervention in acute coronary syndromes - The COMPARE trial

*Circulation (New York, N.Y. : 1950)*, *106*(12), 1470–1476.

Source: NC State University Libraries

Added: August 6, 2018

2001 journal article

A semiparametric estimator for the proportional hazards model with longitudinal covariates measured with error

*BIOMETRIKA*, *88*(2), 447–458.

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, ORCID

Added: August 6, 2018

2001 journal article

Linear mixed models with flexible distributions of random effects for longitudinal data

*BIOMETRICS*, *57*(3), 795–802.

author keywords: longitudinal data; multimodality; random effects; seminonparametric density; semiparametric mixed effects model; skewness

MeSH headings : Biometry; Cholesterol / blood; Data Interpretation, Statistical; Humans; Likelihood Functions; Linear Models; Longitudinal Studies

TL;DR:
It is demonstrated that standard information criteria may be used to choose the tuning parameter and detect departures from normality, and the approach is illustrated via simulation and using longitudinal data from the Framingham study.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2001 journal article

Robust two-stage estimation in hierarchical nonlinear models

*BIOMETRICS*, *57*(1), 266–272.

author keywords: M-estimation; mixed effects; outliers; repeated measurements

MeSH headings : Air Pollutants / toxicity; Algorithms; Animals; Biometry; Least-Squares Analysis; Nonlinear Dynamics; Ozone / toxicity; Rats; Respiratory System / drug effects; Serotonin / pharmacology

TL;DR:
This work proposes a robust two-stage procedure based on Huber's (1981, Robust Statistics) theory of M-estimation to accommodate separately aberrant responses within an experimental unit and subjects deviating from the study population when the usual assumptions of normality are violated.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2000 journal article

Consequences of misspecifying assumptions in nonlinear mixed effects models

*COMPUTATIONAL STATISTICS & DATA ANALYSIS*, *34*(2), 139–164.

author keywords: random effects; nonnormality; Laplace approximation; linearization

TL;DR:
The consequences for population inferences using popular methods for fitting nonlinear mixed effects models when the normality assumption is inappropriate and/or the model is misspecified are investigated.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science; OpenAlex)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2000 journal article

Correcting for measurement error in individual-level covariates in nonlinear mixed effects models

*BIOMETRICS*, *56*(2), 368–375.

author keywords: laplace's approximation; random effects; regression calibration; small sigma

MeSH headings : Biometry / methods; Calibration; Models, Statistical; Pharmacokinetics; Regression Analysis; Virus Physiological Phenomena

TL;DR:
Methods to take account of measurement error that correct this bias are developed and may be implemented with standard software and demonstrated their utility via simulation and application to data from a study of HIV dynamics.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science; OpenAlex)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2000 article

Differences in viral dynamics between genotypes 1 and 2 of hepatitis C virus

Neumann, A. U., Lam, N. P., Dahari, H., Davidian, M., Wiley, T. E., Mika, B. P., … Layden, T. J. (2000, July). *JOURNAL OF INFECTIOUS DISEASES*, Vol. 182, pp. 28–35.

MeSH headings : Antiviral Agents / therapeutic use; Apoptosis; Female; Genotype; Hepacivirus / genetics; Hepacivirus / physiology; Hepatitis C / drug therapy; Hepatitis C / immunology; Hepatitis C / pathology; Hepatitis C / virology; Humans; Interferon-alpha / therapeutic use; Male; Metabolic Clearance Rate; Middle Aged; Models, Theoretical; RNA, Viral / metabolism

TL;DR:
The better response rate of patients infected with HCV genotype 2 is multifactorial, the first finding of a difference in viral dynamics between subtypes of the same virus and demonstrates the importance of subtype-specific virus-host-drug interactions.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science; OpenAlex)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

2000 journal article

Estimating data transformations in nonlinear mixed effects models

*BIOMETRICS*, *56*(1), 65–72.

author keywords: Laplace's approximation; nonlinear mixed effects model; random effects; repeated measurements; small sigma; transform both sides

MeSH headings : Arginine / analogs & derivatives; Biometry / methods; Data Interpretation, Statistical; Humans; Infant, Newborn; Infant, Premature; Likelihood Functions; Monte Carlo Method; Nonlinear Dynamics; Phenobarbital / pharmacokinetics; Pipecolic Acids / pharmacokinetics; Sulfonamides

TL;DR:
A mixed effects framework based on the transform‐both‐sides model, where the transformation is represented by a monotone parametric function and is estimated from the data, is proposed, allowing straightforward implementation via standard software.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

1999 journal article

Human immunodeficiency virus type 1-specific cytotoxic T lymphocyte activity is inversely correlated with HIV type 1 viral load in HIV type 1-infected long-term survivors

*AIDS RESEARCH AND HUMAN RETROVIRUSES*, *15*(13), 1219–1228.

MeSH headings : CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes / immunology; Cross-Sectional Studies; Cytotoxicity Tests, Immunologic; Gene Products, pol / genetics; Gene Products, pol / metabolism; HIV Infections / immunology; HIV Infections / virology; HIV Long-Term Survivors; HIV-1 / immunology; HIV-1 / physiology; Histocompatibility Antigens Class I / classification; Histocompatibility Antigens Class I / genetics; Histocompatibility Antigens Class I / immunology; Humans; Longitudinal Studies; Male; Receptors, CCR5 / genetics; T-Lymphocytes, Cytotoxic / immunology; Viral Load

TL;DR:
The data suggest that the presence of HIV- 1-specific CTL activity in HIV-1-infected long-term survivors is an important component in the effective control of HIV -1 replication.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science; OpenAlex)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

1999 chapter

Invited discussion of “The Bayesian approach to population pharmacokinetic-pharmacodynamic modeling” by Wakefield, Aarons, and Racine-Poon

In C. Gatsonis, R. E. Kass, B. Carlin, A. Carriquiry, A. Gelman, I. Verdinelli, & M. West (Eds.), *Case Studies in Bayesian Statistics*: *Vol.* *IV* (pp. 257–263). New York: Springer-Verlag.

Ed(s): C. Gatsonis, R. Kass, B. Carlin, A. Carriquiry, A. Gelman, I. Verdinelli, M. West

Source: NC State University Libraries

Added: September 27, 2020

1998 journal article

Estimating the parameters in the Cox model when covariate variables are measured with error

*BIOMETRICS*, *54*(4), 1407–1419.

author keywords: cumulative hazards; measurement error; nonparametric maximum likelihood; proportional hazards model; regression calibration; semiparametric method

TL;DR:
A likelihood-based approach is introduced, which is referred to as the semiparametric method, and it is shown that this method is an appealing alternative to the Cox proportional hazards model to analyze the relationship between survival and CD4 count in patients with AIDS.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

1998 journal article

Statistical properties of fitted estimates of apparent in vivo metabolic constants obtained from gas uptake data. I. Lipophilic and slowly metabolized VOCs

*Inhalation Toxicology*, *10*(5), 383–409.

Source: NC State University Libraries

Added: August 6, 2018

1998 journal article

The effect of serial dilution error on calibration inference in immunoassay

*BIOMETRICS*, *54*(1), 19–32.

author keywords: confidence intervals; ELISA; generalized least squares; measurement error; precision profile; variance function estimation

TL;DR:
It is demonstrated that failure to account for serial dilution error in calibration inference on unknown samples leads to serious inaccuracy of assessments of assay precision such as confidence intervals and precision profiles.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

1997 journal article

A two-step approach to measurement error in time-dependent covariates in nonlinear mixed-effects models, with application to IGF-I pharmacokinetics

*Journal of the American Statistical Association*, *92*(438), 436–448.

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(OpenAlex)

Sources: NC State University Libraries, NC State University Libraries

Added: August 6, 2018

1997 journal article

Bootstrap-Adjusted Calibration Confidence Intervals for Immunoassay

*Journal of the American Statistical Association*, *92*(437), 278–290.

Sources: Crossref, NC State University Libraries

Added: January 24, 2020

1997 journal article

Calibration inference based on multiple runs of an immunoassay

*BIOMETRICS*, *53*(4), 1304–1317.

author keywords: confidence interval; empirical Bayes; nonlinear mixed effects; pooled variance estimation

TL;DR:
Methods for combining information from multiple runs to estimate assay response variance parameters and to refine characterization of the standard curve for the current run via empirical Bayes techniques are investigated formally.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

1. No Poverty
(OpenAlex)

2. Zero Hunger
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

1997 journal article

Testing homogeneity of intra-run variance parameters in immunoassay

*STATISTICS IN MEDICINE*, *16*(15), 1765–1776.

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

1996 journal article

A note on covariate measurement error in nonlinear mixed effects models

*Biometrika*, *83*(4), 801–812.

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Crossref, NC State University Libraries

Added: February 24, 2020

1996 journal article

Denaturation and Aggregation of Chicken Myosin Isoforms

*Journal of Agricultural and Food Chemistry*, *44*(6), 1435–1440.

author keywords: myosin; aggregation; denaturation; muscle protein

TL;DR:
Heat-induced denaturation and aggregation of chicken myosins isolated from one white muscle (pectoralis) and two red muscles (iliotibialis and gastrocnemius) were investigated using differential scanning calorimetry and turbidity measurements.
(via Semantic Scholar)

Sources: Crossref, NC State University Libraries

Added: January 24, 2020

1996 journal article

Organic Matter Decomposition following Harvesting and Site Preparation of a Forested Wetland

*Soil Science Society of America Journal*, *60*(6), 1994–2003.

UN Sustainable Development Goal Categories

2. Zero Hunger
(Web of Science)

13. Climate Action
(Web of Science)

15. Life on Land
(Web of Science; OpenAlex)

Sources: Crossref, NC State University Libraries

Added: January 24, 2020

1996 journal article

Pyrimethamine pharmacokinetics in human immunodeficiency virus-positive patients seropositive for Toxoplasma gondii.

*Antimicrobial Agents and Chemotherapy*, *40*(6), 1360–1365.

MeSH headings : AIDS-Related Opportunistic Infections / drug therapy; AIDS-Related Opportunistic Infections / metabolism; Drug Interactions; HIV Infections / drug therapy; HIV Infections / metabolism; Half-Life; Humans; Male; Pyrimethamine / adverse effects; Pyrimethamine / pharmacokinetics; Toxoplasmosis / drug therapy; Toxoplasmosis / metabolism; Zidovudine / pharmacokinetics; Zidovudine / therapeutic use

TL;DR:
Pyrimethamine exhibited pharmacokinetics in HIV-infected patients that were similar to those in non-HIV- infected subjects and it did not alter the pharmacokinetic of zidovudine in these patients.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(OpenAlex)

Sources: Crossref, NC State University Libraries

Added: January 24, 2020

1996 journal article

The Effect of Variance Function Estimation on Nonlinear Calibration Inference in Immunoassay Data

*Biometrics*, *52*(1), 158.

author keywords: assay; confidence interval; generalized least squares; heteroscedasticity; variance function estimation

TL;DR:
Calibration inference for immunoassay data which exhibit this nonlinear heteroscedastic mean-variance relationship is discussed, and an assessment of the effect of variance function estimation in three types of approximate large-sample confidence intervals for unknown concentrations is given.
(via Semantic Scholar)

Sources: Crossref, NC State University Libraries

Added: January 24, 2020

1995 book

Nonlinear models for repeated measurement data

In *Chapman & Hall/CRC*. Boca Raton, FL: Boca Raton: Chapman & Hall.

Event: at Boca Raton, FL

Sources: NC State University Libraries, ORCID

Added: August 6, 2018

1995 journal article

Therapeutic effects of diethylcarbamazine and 3′-azido-3′-deoxythymidine on feline leukemia virus lymphoma formation

*Veterinary Immunology and Immunopathology*, *46*(1-2), 181–194.

MeSH headings : Animals; Antibodies, Viral / blood; Cat Diseases / drug therapy; Cat Diseases / immunology; Cats; Diethylcarbamazine / administration & dosage; Diethylcarbamazine / therapeutic use; Enzyme-Linked Immunosorbent Assay / veterinary; Flow Cytometry / veterinary; Gene Products, gag / immunology; Leukemia Virus, Feline / drug effects; Leukemia Virus, Feline / immunology; Leukocyte Count / veterinary; Leukopenia / drug therapy; Leukopenia / immunology; Lymphocytes / immunology; Lymphoma / drug therapy; Lymphoma / immunology; Lymphoma / veterinary; Random Allocation; Retroviridae Infections / drug therapy; Retroviridae Infections / immunology; Retroviridae Infections / veterinary; Retroviridae Proteins, Oncogenic / immunology; Specific Pathogen-Free Organisms; Survival Rate; Tumor Virus Infections / drug therapy; Tumor Virus Infections / immunology; Tumor Virus Infections / veterinary; Viral Envelope Proteins / immunology; Zidovudine / administration & dosage; Zidovudine / therapeutic use

TL;DR:
DEC as well as AZT therapy delays the development of lymphomas associated with FeLV infection and significantly improves survival, suggesting FeLVR-induced immunosuppression.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Crossref, NC State University Libraries, Web Of Science

Added: August 6, 2018

1994 journal article

Assays for recombinant proteins: A problem in non-linear calibration

*Statistics in Medicine*, *13*(11), 1165–1179.

MeSH headings : Bayes Theorem; Biological Assay / methods; Biological Assay / standards; Biological Assay / statistics & numerical data; Calibration; Humans; Likelihood Functions; Models, Biological; Nonlinear Dynamics; Recombinant Proteins / blood; Regression Analysis; Reproducibility of Results

TL;DR:
It is shown that proper characterization of intra-assay variability requires pooling of information across several assay runs, and that use of empirical Bayes methods in calibration may afford considerable gain in efficiency.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Crossref, NC State University Libraries

Added: January 24, 2020

1994 journal article

Low serum antibacterial activity coincides with increased prevalence of shell disease in blue crabs Callinectes sapidus

*Diseases of Aquatic Organisms*, *19*(2), 121–128.

author keywords: INVERTEBRATE IMMUNITY; BACTERICIDINS; BACTERIAL DISEASE

TL;DR:
In commercially important blue crabs Callinectes sapidus from the Albemarle-Pamlico Estuary, North Carolina, USA, potent antibacterial activity was identified which was active against most of the bacteria inhabiting the shell of both clinically normal crabs as well as those with shell disease.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Crossref, NC State University Libraries, Web Of Science

Added: August 6, 2018

1994 journal article

Population Pharmacokinetic/Pharmacodynamic Methodology and Applications: A Bibliography

*Biometrics*, *50*(2), 566.

author keywords: NONLINEAR MIXED EFFECTS MODEL; POPULATION PHARMACOKINETICS/PHARMACODYNAMICS

TL;DR:
This bibliography lists all published methodological works (statistical methodology, implementation methodology, review papers, descriptions of software) in the area of population pharmacokinetics/pharmacodynamics up to 1993 and all published works describing applications of population pharmaceuticals up to 1992.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Crossref, NC State University Libraries

Added: January 24, 2020

1993 journal article

Analysis of repeated measurement data using the nonlinear mixed effects model

*Chemometrics and Intelligent Laboratory Systems*, *20*(1), 1–24.

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

6. Clean Water and Sanitation
(OpenAlex)

Sources: Crossref, NC State University Libraries

Added: January 24, 2020

1993 journal article

Some Simple Methods for Estimating Intraindividual Variability in Nonlinear Mixed Effects Models

*Biometrics*, *49*(1), 59.

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Crossref, NC State University Libraries

Added: January 24, 2020

1993 journal article

Some general estimation methods for nonlinear mixed-effects model

*Journal of Biopharmaceutical Statistics*, *3*(1), 23–55.

MeSH headings : Calibration; Computer Simulation; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Female; Humans; Least-Squares Analysis; Likelihood Functions; Models, Biological; Models, Statistical; Relaxin / pharmacology; Software; Soybeans / growth & development

TL;DR:
A nonlinear mixed-effects model suitable for characterizing repeated measurement data and two classes of procedures for estimation in this model are described, which incorporate estimation of unknown parameters in the assumed intraindividual covariance structure.
(via Semantic Scholar)

Sources: Crossref, NC State University Libraries

Added: January 24, 2020

1993 journal article

The nonlinear mixed effects model with a smooth random effects density

*Biometrika*, *80*(3), 475–488.

Sources: Crossref, NC State University Libraries

Added: January 24, 2020

1992 journal article

Smooth nonparametric maximum likelihood estimation for population pharmacokinetics, with application to quinidine

*Journal of Pharmacokinetics and Biopharmaceutics*, *20*(5), 529–556.

author keywords: POPULATION PHARMACOKINETICS; NONLINEAR MIXED EFFECTS MODELS; DENSITY ESTIMATION; NONPARAMETRIC ESTIMATION; MAXIMUM LIKELIHOOD; QUINIDINE

MeSH headings : Absorption; Bayes Theorem; Female; Genetic Variation / physiology; Humans; Male; Mathematical Computing; Methods; Models, Biological; Pharmacokinetics; Population; Quinidine / pharmacokinetics; Software

TL;DR:
The seminonparametric (SNP) method, popular in the econometrics literature, is proposed for use in population pharmacokinetic analysis and a graphical modelbuilding strategy based on the SNP method is described.
(via Semantic Scholar)

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Crossref, NC State University Libraries

Added: January 24, 2020

1991 report

Infectious bursal disease virus titers may be misleading

In *Breakthrough, North Carolina Cooperative Extension Service* (Vol. 15).

Source: NC State University Libraries

Added: September 27, 2020

1991 conference paper

The use of regression analysis in nonwovens research

*Proceedings of the TAPPI 1991 Nonwovens Conference*, 27–33. Atlanta, Georgia: TAPPI Press.

Source: NC State University Libraries

Added: January 27, 2020

1990 journal article

Estimation of variance functions in assays with possibly unequal replication and nonnormal data

*Biometrika*, *77*(1), 43–54.

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Crossref, NC State University Libraries

Added: January 24, 2020

1990 journal article

Regression and calibration with nonconstant error variance

*Chemometrics and Intelligent Laboratory Systems*, *9*(3), 231–248.

Sources: Crossref, NC State University Libraries

Added: January 24, 2020

1988 journal article

A Note on Extended Quasi-Likelihood

*Journal of the Royal Statistical Society: Series B (Methodological)*, *50*(1), 74–82.

Sources: Crossref, NC State University Libraries

Added: January 24, 2020

1988 journal article

Variance functions and the minimum detectable concentration in assays

*Biometrika*, *75*(3), 549–556.

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Crossref, NC State University Libraries

Added: January 24, 2020

1987 journal article

VARIANCE FUNCTION ESTIMATION

*JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION*, *82*(400), 1079–1091.

UN Sustainable Development Goal Categories

3. Good Health and Well-being
(Web of Science)

Sources: Web Of Science, NC State University Libraries

Added: August 6, 2018

Updated: November 3rd, 2019 14:47

1987 - present

Updated: November 3rd, 2019 14:48

1982 - 1987

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