Works (151)
Updated: April 4th, 2024 12:56
2024 article
Estimation of optimal treatment regimes with electronic medical record data using the residual life value estimator
Rhodes, G., Davidian, M., & Lu, W. (2024, February 9). BIOSTATISTICS, Vol. 2.
author keywords: context vector; dynamic treatment regime; electronic medical record; MIMIC-III; precision medicine; Q-learning; random forest; residual life; sepsis
TL;DR:
ReLiVE-Q leverages accumulating patient information to estimate personalized treatment regimes that optimize a clinically meaningful function of residual life, and it is demonstrated that ReLiVE-Q leverages accumulating patient information to estimate personalized treatment regimes that optimize a clinically meaningful function of residual life.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: February 19, 2024
2023 journal article
Behavioral cancer pain intervention dosing: results of a Sequential Multiple Assignment Randomized Trial
PAIN, 164(9), 1935–1941.
author keywords: Behavioral pain intervention; Coping skills; SMART design; Breast cancer; Pain
TL;DR:
Varying PCST doses led to pain reduction over time, and intervention sequences demonstrating the most durable decreases in pain reduction included PCST-Full.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: September 18, 2023
2023 journal article
Cost-Effectiveness Analysis Evaluating Delivery Strategies for Pain Coping Skills Training in Women With Breast Cancer
JOURNAL OF PAIN, 24(9), 1712–1720.
author keywords: Cost-effectiveness; pain coping skills training; cancer pain; cognitive-behavioral therapy; behavioral pain management
TL;DR:
A cost-analysis of the delivery of Pain Coping Skills Training, a non-pharmacological intervention, to women with breast cancer and pain could potentially provide important cost-related information to healthcare providers and systems on the use of an efficacious and accessible non-medication strategy for pain management.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 23, 2023
2023 journal article
DYNAMIC PREDICTION OF RESIDUAL LIFE WITH LONGITUDINAL COVARIATES USING LONG SHORT-TERM MEMORY NETWORKS
ANNALS OF APPLIED STATISTICS, 17(3), 2039–2058.
author keywords: Biomarker; dynamic prediction; electronic medical record; long short-term memory network; longitudinal data; MIMIC-III; neural network; residual life; sepsis; transformed mean residual life model
TL;DR:
It is demonstrated that the L STM-GLM and the LSTM-NN are useful tools for producing individualized, real-time predictions of RMRL that can help inform the treatment decisions of septic patients.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: November 6, 2023
2023 article
Interim monitoring of sequential multiple assignment randomized trials using partial information
Manschot, C., Laber, E., & Davidian, M. (2023, March 22). BIOMETRICS, Vol. 3.
author keywords: augmented inverse probability weighting; clinical trials; double robustness; dynamic treatment regimes; early stopping; group sequential analysis
TL;DR:
An estimator for the mean outcome under a given regime that gains efficiency by using partial information from enrolled participants regardless of their progression through treatment stages is proposed.
(via Semantic Scholar)
arxiv.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 4, 2023
2022 article
A general framework for subgroup detection via one-step value difference estimation
Johnson, D., Lu, W., & Davidian, M. (2022, August 2). BIOMETRICS, Vol. 8.
author keywords: exceptional law; optimal treatment rule; precision medicine; subgroup test; survival analysis; value function
TL;DR:
This work proposes a general framework for testing for the existence of a subgroup with enhanced treatment effects based on the difference of the estimated value functions under an estimated optimal treatment regime and a fixed regime that assigns everyone to the same treatment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
16. Peace, Justice and Strong Institutions
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 15, 2022
2022 article
Group sequential methods for interim monitoring of randomized clinical trials with time-lagged outcome
Tsiatis, A. A., & Davidian, M. (2022, September 18). STATISTICS IN MEDICINE, Vol. 9.
author keywords: augmented inverse probability weighting; early stopping; influence function; proportion of information
MeSH headings : Humans; Randomized Controlled Trials as Topic; Odds Ratio; Research Design
TL;DR:
Treatment effect estimators that take account of censoring and incorporate covariate information at an interim analysis are derived using semiparametric theory and are demonstrated to lead to stronger evidence for early stopping than standard approaches.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 3, 2022
2022 journal article
Methods Based on Semiparametric Theory for Analysis in the Presence of Missing Data
ANNUAL REVIEW OF STATISTICS AND ITS APPLICATION, 9, 167–196.
author keywords: augmentation; double robustness; influence function; inverse probability weighting of complete cases; missing at random; monotone missingness
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: May 31, 2022
2022 journal article
Telehealth and racial disparities in colorectal cancer screening: A pilot study of how virtual clinician characteristics influence screening intentions
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE, 6(1).
author keywords: Cancer health disparities; colorectal cancer screening; telehealth; virtual human technology; precision prevention
TL;DR:
This study suggests that telehealth interventions that match Black patients with a Black VC can enhance perceptions of credibility and message relevance, which may then improve screening intentions, which is needed to reduce racial CRC screening disparities.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: May 23, 2022
2021 journal article
A Pilot Study Examining the Efficacy of Delivering Colorectal Cancer Screening Messages via Virtual Health Assistants
American Journal of Preventive Medicine, 61(2), 251–255.
MeSH headings : Adult; Black or African American; Colorectal Neoplasms / diagnosis; Early Detection of Cancer; Humans; Mass Screening; Pilot Projects
TL;DR:
Animated virtual healthcare assistants were efficacious compared with the staticvirtual healthcare assistant and attention control conditions and warrants additional investigation in future studies given the potential for virtual healthcare assistant‒assisted interventions to promote colorectal cancer screening within guidelines.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education
(OpenAlex)
Source: ORCID
Added: January 26, 2023
2021 article
Estimating vaccine efficacy over time after a randomized study is unblinded
Tsiatis, A. A., & Davidian, M. (2021, August 13). BIOMETRICS, Vol. 8.
author keywords: crossover; inverse probability weighting; potential outcomes; randomized phase 3 vaccine trial; waning vaccine efficacy
MeSH headings : COVID-19 / prevention & control; COVID-19 Vaccines; Humans; Pandemics / prevention & control; Randomized Controlled Trials as Topic; Research Design; SARS-CoV-2; Vaccine Efficacy
TL;DR:
This work focuses on the particular features of the Moderna trial and proposes a statistical framework based on a potential outcomes formulation within which methods for inference on potential waning of VE over time and estimation ofVE at any postvaccination time are developed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 23, 2021
2021 article
Estimation of the odds ratio in a proportional odds model with censored time-lagged outcome in a randomized clinical trial
Tsiatis, A. A., Davidian, M., & Holloway, S. T. (2021, December 17). BIOMETRICS, Vol. 12.
author keywords: augmented inverse probability weighting; censored ordinal categorical outcome; covariate adjustment; COVID-19 treatment; estimating function; marked point process
TL;DR:
An estimator for the OR in a proportional odds model with censored, time‐lagged categorical outcome that incorporates additional baseline and time‐dependent covariate information and demonstrates that it can result in considerable gains in efficiency relative to simpler approaches is proposed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: December 17, 2021
2021 article
Rejoinder: Estimating vaccine efficacy over time after a randomized study is unblinded
Tsiatis, A. A., & Davidian, M. (2021, August 22). BIOMETRICS, Vol. 8.
MeSH headings : Randomized Controlled Trials as Topic; Vaccine Efficacy
TL;DR:
Responding to the points they raise has enhanced the understanding of the area and the role of the work within it, and all note challenges posed by viral variants.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 30, 2021
2020 book
Dynamic Treatment Regimes: Statistical Methods for Precision Medicine
In CRC Press.
Event: at Boca Raton, FL
Sources: ORCID, NC State University Libraries
Added: January 23, 2020
2019 review
Application of a sequential multiple assignment randomized trial (SMART) design in older patients with chronic lymphocytic leukemia
[Review of ]. ANNALS OF ONCOLOGY, 30(4), 542–550.
author keywords: SMART; CLL; design strategies; adaptive interventions; randomized clinical trials
MeSH headings : Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Data Analysis; Disease Progression; Feasibility Studies; Humans; Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy; Leukemia, Lymphocytic, Chronic, B-Cell / mortality; Progression-Free Survival; Randomized Controlled Trials as Topic; Research Design; Sample Size
TL;DR:
SMART design strategies can be used in cancer clinical trials with adaptive interventions to identify optimal treatment strategies and are appropriate when comparing adaptive interventions, which are defined by an individual's sequence of treatment decisions and guided by intermediate outcomes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 17, 2019
2018 journal article
Interpretable Dynamic Treatment Regimes
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, 113(524), 1541–1549.
author keywords: Decision lists; Interpretability; Precision medicine; Research-practice gap; Treatment regimes; Tree-based methods
TL;DR:
An estimator of an optimal treatment regime composed of a sequence of decision rules, each expressible as a list of “if-then” statements that can be presented as either a paragraph or as a simple flowchart that is immediately interpretable to domain experts is proposed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: February 18, 2019
2018 journal article
Optimal two-stage dynamic treatment regimes from a classification perspective with censored survival data
BIOMETRICS, 74(4), 1180–1192.
author keywords: Doubly robust; Inverse probability weighting; Optimal treatment regime; Sequential multiple assignment randomized trial; Support vector machine; Value search
MeSH headings : Acute Disease; Algorithms; Biometry / methods; Computer Simulation; Decision Support Techniques; Humans; Leukemia; Outcome Assessment, Health Care / methods; Outcome Assessment, Health Care / standards; Randomized Controlled Trials as Topic; Support Vector Machine; Survival Analysis
TL;DR:
A method for estimation of an optimal regime involving two decision points when the outcome of interest is a censored survival time is proposed, based on maximizing a locally efficient, doubly robust, augmented inverse probability weighted estimator for average outcome over a class of regimes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
16. Peace, Justice and Strong Institutions
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 25, 2019
2018 entry reference
Q-Learning
UN Sustainable Development Goal Categories
16. Peace, Justice and Strong Institutions
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 19, 2020
2017 journal article
Biometrics, JABES and the International Biometric Society
Journal of Agricultural, Biological and Environmental Statistics, 22(3), 221–223.
Sources: Crossref, NC State University Libraries
Added: January 13, 2020
2017 journal article
Dynamic treatment regimes, past, present, and future: A conversation with experts
STATISTICAL METHODS IN MEDICAL RESEARCH, 26(4), 1605–1610.
author keywords: Optimal dynamic treatment regime; sequential multiple assignment randomized trial; mHealth; clinical trials; treatment sequence
MeSH headings : Datasets as Topic / trends; History, 20th Century; History, 21st Century; Humans; Precision Medicine / trends; Randomized Controlled Trials as Topic / history; Randomized Controlled Trials as Topic / methods
TL;DR:
Three leading researchers in the area of dynamic treatment regimes are asked to share their stories on how they became interested in this topic and their perspectives on the most important opportunities and challenges for the future.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2017 journal article
Optimizing delivery of a behavioral pain intervention in cancer patients using a sequential multiple assignment randomized trial SMART
Contemporary Clinical Trials, 57, 51–57.
author keywords: Smart; Novel trial designs; Breast cancer; Pain; Pain coping skills training; Symptom management
MeSH headings : Adaptation, Psychological; Adult; Breast Neoplasms / complications; Breast Neoplasms / therapy; Cognitive Behavioral Therapy / economics; Cognitive Behavioral Therapy / methods; Cost-Benefit Analysis; Female; Humans; Pain Management / economics; Pain Management / methods; Pain Measurement
TL;DR:
This is one of the first trials to use a novel design to evaluate symptom management in cancer patients and in chronic illness; if successful, it could serve as a model for future work with a wide range of chronic illnesses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2017 article
Special Issue of Journal of Biopharmaceutical Statistics dedicated to 2016 Trends and Innovations in Clinical Trial Statistics (TICTS) Conference
JOURNAL OF BIOPHARMACEUTICAL STATISTICS, Vol. 27, pp. 357–357.
MeSH headings : Biological Products; Biopharmaceutics / statistics & numerical data; Clinical Trials as Topic / statistics & numerical data; Congresses as Topic
TL;DR:
The issue includes articles on missing data, multiple comparisons, sample size re-estimation, Bayesian methods and applications, strategies for estimating a homogeneous treatment effect in observational studies, use of modeling and simulations to improve decision making, and methods in oncology.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2017 journal article
Survival benefit of lung transplantation in the modern era of lung allocation
Annals of the American Thoracic Society, 14(2), 172–181.
Source: NC State University Libraries
Added: August 6, 2018
2017 personal communication
The analysis of multivariate longitudinal data: A review: Response to letter of M. Gebregziabher
Verbeke, G., Fieuws, S., Molenberghs, G., & Davidian, M. (2017, February).
MeSH headings : Longitudinal Studies; Multivariate Analysis
TL;DR:
This research presents a novel and scalable approach to solving the challenge of integrating bioinformatics into the traditional e-commerce system.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2016 journal article
A Placebo-Controlled, Prospective, Randomized Clinical Trial of Polyethylene Glycol and Methylprednisolone Sodium Succinate in Dogs with Intervertebral Disk Herniation
JOURNAL OF VETERINARY INTERNAL MEDICINE, 30(1), 206–214.
Contributors: N. Olby n , A. Muguet-Chanoit n, J. Lim n, n , C. Mariani n , A. Freeman*, S. Platt *, J. Humphrey n
author keywords: Neuroprotection; Paraplegia; Secondary injury; Spinal cord injury
MeSH headings : Animals; Anti-Inflammatory Agents / administration & dosage; Anti-Inflammatory Agents / therapeutic use; Dog Diseases / drug therapy; Dogs; Female; Intervertebral Disc Displacement / drug therapy; Intervertebral Disc Displacement / veterinary; Male; Methylprednisolone Hemisuccinate / administration & dosage; Methylprednisolone Hemisuccinate / therapeutic use; Nociception / drug effects; Polyethylene Glycols / administration & dosage; Polyethylene Glycols / therapeutic use
TL;DR:
This clinical trial did not show a benefit of either MPSS or PEG in the treatment of acute, severe thoracolumbar IVDH when used as adjunctive medical treatment administered to dogs presenting within 24 hours of onset of paralysis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2016 chapter
Dynamic treatment regimes
In S. L. George, X. Wang, & H. Pang (Eds.), Cancer Clinical Trials: Current and Controversial Issues in Design and Analysis (pp. 409–446). Boca Raton: Chapman & Hall/CRC Press.
Ed(s): S. George, X. Wang & H. Pang
Source: NC State University Libraries
Added: January 27, 2020
2016 article
Estimating optimal treatment regimes from a classification perspective (vol 1, pg 103, 2012)
STAT, Vol. 5, pp. 278–278.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2016 journal article
On estimation of optimal treatment regimes for maximizing t -year survival probability
Journal of the Royal Statistical Society: Series B (Statistical Methodology), 79(4), 1165–1185.
author keywords: Inverse probability weighted estimation; Kaplan-Meier estimator; Optimal treatment regime; Personalized medicine; Survival probability; Value function
TL;DR:
This work proposes two non‐parametric estimators for the survival function of patients following a given treatment regime involving one or more decisions, i.e. the so‐called value, and introduces kernel smoothing within the estimator to improve performance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2016 entry reference
Optimal Dynamic Treatment Regimes
Sources: Crossref, NC State University Libraries
Added: January 19, 2020
2016 journal article
Ten Simple Rules for Effective Statistical Practice
PLOS Computational Biology, 12(6), e1004961.
Ed(s): F. Lewitter
MeSH headings : Algorithms; Computational Biology / methods; Computer Simulation; Data Accuracy; Data Interpretation, Statistical; Information Dissemination / methods; Models, Statistical
TL;DR:
This list of rules for putting together a Ten Simple Rules article related to statistics was developed with researchers in mind: researchers having some knowledge of statistics, possibly with one or more statisticians available in their building, or with a healthy do-it-yourself attitude and a handful of statistical packages on their laptops.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2015 journal article
A robust method for estimating optimal treatment regimes
Biometrics, 71, 271–273.
MeSH headings : Breast Neoplasms / epidemiology; Breast Neoplasms / therapy; Clinical Trials as Topic / methods; Decision Support Systems, Clinical; Female; Humans; Models, Statistical; Outcome Assessment, Health Care / methods
Sources: Crossref, NC State University Libraries
Added: January 27, 2020
2015 chapter
Chapter 9: Value search estimators for optimal dynamic treatment regimes
In Adaptive Treatment Strategies in Practice (pp. 135–155).
Sources: Crossref, NC State University Libraries
Added: January 22, 2020
2015 journal article
Estimation After a Group Sequential Trial
STATISTICS IN BIOSCIENCES, 7(2), 187–205.
author keywords: Exponential family; Frequentist inference; Generalized sample average; Joint modeling; Likelihood inference; Missing at random; Sample average
TL;DR:
It is shown that the ordinary sample average is a viable option for estimation following a group sequential trial, for a wide class of stopping rules and for random outcomes with a distribution in the exponential family, and it is consistent and asymptotically unbiased.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
Properties of Estimators in Exponential Family Settings with Observationbased Stopping Rules
Journal of Biometrics & Biostatistics, 07(01).
TL;DR:
It is established that the ordinary sample average is a very sensible choice, contrary to commonly encountered statements, in the context of outcomes following an exponential family distribution and with a stochastic stopping rule that includes a deterministic rule and completely random sample size as special cases.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 19, 2020
2015 journal article
Using Decision Lists to Construct Interpretable and Parsimonious Treatment Regimes
BIOMETRICS, 71(4), 895–904.
author keywords: Decision lists; Exploratory analyses; Interpretability; Personalized medicine; Treatment regimes
MeSH headings : Biometry / methods; Breast Neoplasms / drug therapy; Clinical Protocols; Clinical Trials as Topic / statistics & numerical data; Computer Simulation; Decision Trees; Depression / therapy; Evidence-Based Medicine / statistics & numerical data; Female; Humans; Models, Statistical; Precision Medicine / statistics & numerical data
TL;DR:
A simple, yet flexible class of treatment regimes whose members are representable as a short list of if–then statements are proposed, which are immediately interpretable and are therefore an appealing choice for broad application in practice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
Using pilot data to size a two-arm randomized trial to find a nearly optimal personalized treatment strategy
Statistics in Medicine, 35(8), 1245–1256.
author keywords: personalized medicine; sample size calculation; treatment regimes; nonregular asymptotics; projection confidence region
MeSH headings : Biostatistics; Computer Simulation; Confidence Intervals; Data Interpretation, Statistical; Evidence-Based Practice / statistics & numerical data; Female; Fertility; Humans; Male; Models, Statistical; Pilot Projects; Precision Medicine / statistics & numerical data; Pregnancy; Randomized Controlled Trials as Topic / statistics & numerical data; Regression Analysis; Sample Size
TL;DR:
This work offers a simple and robust method for powering a single stage, two‐armed randomized clinical trial when the primary aim is estimating the optimal single stage personalized treatment strategy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018
2014 personal communication
Collaboration To Meet the Statistical Needs in the Chemistry Curriculum
Davidian, M., & Kutal, C. (2014, January).
author keywords: General Public; First-Year Undergraduate/General; Second-Year Undergraduate; Interdisciplinary/Multidisciplinary; Curriculum
UN Sustainable Development Goal Categories
4. Quality Education
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 article
Combining Biomarkers to Optimize Patient Treatment Recommendations Discussions
Laber, E. B., Tsiatis, A. A., Davidian, M., & Holloway, S. T. (2014, September). BIOMETRICS, Vol. 70, pp. 707–710.
MeSH headings : Biomarkers, Tumor / blood; Biometry / methods; Breast Neoplasms / blood; Breast Neoplasms / therapy; Data Interpretation, Statistical; Female; Humans; Male; Outcome Assessment, Health Care / methods
TL;DR:
It is shown how the method of KJH can be used with existing policy-search methods to construct a treatment rule that is interpretable, logistically feasible, parsimonious, or otherwise appealing.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
4. Quality Education
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 chapter
Missing data methods: A semiparametric perspective
In G. Fitzmaurice, M. Kenward, G. Molenberghs, A. A. Tsiatis, & G. Verbeke (Eds.), Handbook of Missing Data. Boca Raton: Chapman & Hall/CRC Press.
Ed(s): G. Fitzmaurice, M. Kenward, G. Molenberghs, A. Tsiatis & G. Verbeke
Source: NC State University Libraries
Added: January 27, 2020
2014 journal article
On random sample size, ignorability, ancillarity, completeness, separability, and degeneracy: Sequential trials, random sample sizes, and missing data
STATISTICAL METHODS IN MEDICAL RESEARCH, 23(1), 11–41.
author keywords: Frequentist inference; generalized sample average; informative cluster size; joint modeling; likelihood inference; missing at random; random cluster size
MeSH headings : Likelihood Functions; Models, Statistical; Probability; Sample Size
TL;DR:
The aim is to place various related examples into a single framework derived from the joint modeling of the outcomes and sampling process and so derive generic results that in turn provide insight, and in some cases practical consequences, for different settings.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Publishing without perishing and other career advice
Past, Present, and Future of Statistical Science, 581–591.
Source: NC State University Libraries
Added: August 6, 2018
2014 journal article
Q- and A-Learning Methods for Estimating Optimal Dynamic Treatment Regimes
STATISTICAL SCIENCE, 29(4), 640–661.
author keywords: Advantage learning; bias-variance trade-off; model misspecification; personalized medicine; potential outcomes; sequential decision-making
TL;DR:
This work provides a detailed account of Q- and A-learning methods, study their performance, and illustrate them using data from a depression study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 chapter
Research Methods for Clinical Trials in Personalized Medicine: A Systematic Review
In Lost in Translation (pp. 659–684).
TL;DR:
Much work is needed to standardize and improve statistical methods for finding biomarkers, validating results, and efficiently optimizing better individual treatment strategies in personalized medicine.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 22, 2020
2014 journal article
SNP_NLMM: A SAS Macro to Implement a Flexible Random Effects Density for Generalized Linear and Nonlinear Mixed Models
Journal of Statistical Software, 56(Code Snippet 2).
TL;DR:
A SAS macro, SNP_NLMM, is developed that overcomes the computational challenges to fit GLMMs and NLMMs where the random effects are assumed to follow a smooth density that can be represented by the seminonparametric formulation proposed by Gallant and Nychka (1987).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 22, 2020
2014 book
Sources: Crossref, NC State University Libraries
Added: August 6, 2018
2014 journal article
The analysis of multivariate longitudinal data: A review
STATISTICAL METHODS IN MEDICAL RESEARCH, 23(1), 42–59.
author keywords: Mixed models; random effects; shared parameters; marginal models; conditional models; latent variables
MeSH headings : Hearing; Humans; Longitudinal Studies; Models, Statistical; Multivariate Analysis
TL;DR:
This article will present a review of the many approaches proposed in the statistical literature, and four main model families will be presented, discussed and compared.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 journal article
Assessing the Causal Effect of Organ Transplantation on the Distribution of Residual Lifetime
BIOMETRICS, 69(4), 820–829.
author keywords: Causal inference; G-estimation; Lung transplantation; Martingale theory; Structural nested failure time models
MeSH headings : Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Causality; Data Interpretation, Statistical; Humans; Internationality; Life Expectancy; Lung Diseases / mortality; Lung Diseases / surgery; Lung Transplantation / mortality; Middle Aged; Outcome Assessment, Health Care / methods; Survival Rate; Young Adult
TL;DR:
A version of G‐estimation is developed that accounts for the fact that treatment assignment is not independent across individuals to estimate the parameters of a structural nested failure time model and leads to valid inference of the effect of transplantation on the distribution of residual lifetime.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 chapter
Bias Reduction in Logistic Regression with Estimated Variance Predictors
In ISS-2012 Proceedings Volume On Longitudinal Data Analysis Subject to Measurement Errors, Missing Values, and/or Outliers (pp. 33–51).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: March 13, 2020
2013 journal article
Building the Biostatistics Pipeline: Summer Institutes for Training in Biostatistics (SIBS)
CHANCE, 26(1), 4–9.
TL;DR:
Behind all these discoveries is biostatistics—the science of development of statistical theory and methods for application to data-driven challenges in the health sciences.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 23, 2020
2013 journal article
Moment adjusted imputation for multivariate measurement error data with applications to logistic regression
COMPUTATIONAL STATISTICS & DATA ANALYSIS, 67, 15–24.
author keywords: Moment adjusted imputation; Multivariate measurement error; Logistic regression; Regression calibration
TL;DR:
Moment Adjusted Imputation is method for measurement error in a scalar latent variable that is easy to implement and performs well in a variety of settings and the extension of MAI to the setting of multivariate latent variables involves unique challenges.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 journal article
Robust estimation of optimal dynamic treatment regimes for sequential treatment decisions
BIOMETRIKA, 100(3), 681–694.
author keywords: A-learning; Double robustness; Outcome regression; Propensity score; Q-learning
TL;DR:
This work proposes an alternative to Q- and A-learning that maximizes a doubly robust augmented inverse probability weighted estimator for population mean outcome over a restricted class of regimes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2013 article
The International Year of Statistics: A Celebration and A Call to Action
Davidian, M. (2013, December). JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, Vol. 108, pp. 1141–1146.
UN Sustainable Development Goal Categories
12. Responsible Consumption and Production
(Web of Science)
16. Peace, Justice and Strong Institutions
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
A Robust Method for Estimating Optimal Treatment Regimes
BIOMETRICS, 68(4), 1010–1018.
author keywords: Doubly robust estimator; Inverse probability weighting; Outcome regression; Personalized medicine; Potential outcomes; Propensity score
MeSH headings : Breast Neoplasms / epidemiology; Breast Neoplasms / therapy; Clinical Trials as Topic / methods; Computer Simulation; Decision Support Systems, Clinical; Female; Humans; Models, Statistical; Outcome Assessment, Health Care / methods; Prevalence; Regression Analysis; Treatment Outcome
TL;DR:
A doubly robust augmented inverse probability weighted estimator is used for finding the optimal regime within a class of regimes by finding the regime that optimizes an estimator of overall population mean outcome.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Estimating optimal treatment regimes from a classification perspective
Stat, 1(1), 103–114.
author keywords: classification; doubly robust estimator; inverse probability weighting; personalized medicine; potential outcomes; propensity score
TL;DR:
This work proposes a novel and general framework that transforms the problem of estimating an optimal treatment regime into a classification problem wherein the optimal classifier corresponds to the optimalreatment regime.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: January 23, 2020
2012 journal article
Mixed model analysis of censored longitudinal data with flexible random-effects density
BIOSTATISTICS, 13(1), 61–73.
author keywords: Censoring; HCV; HIV; Limit of quantification; Longitudinal data; Random effects
MeSH headings : Antiviral Agents / therapeutic use; Bias; Biostatistics; Data Interpretation, Statistical; Hepatitis C / drug therapy; Hepatitis C / virology; Humans; Interferon-alpha / therapeutic use; Linear Models; Longitudinal Studies; Models, Statistical; Statistics, Nonparametric; Viral Load / drug effects
TL;DR:
A mixed model framework for censored longitudinal data in which the random effects are represented by the flexible seminonparametric density is developed andSimulations show that this approach can lead to reduction in bias and increase in efficiency relative to assuming Gaussian random effects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Variable selection for covariate-adjusted semiparametric inference in randomized clinical trials
STATISTICS IN MEDICINE, 31(29), 3789–3804.
author keywords: covariate adjustment; false selection rate control; oracle property; semiparametric treatment effect estimation; shrinkage methods; variable selection
MeSH headings : Algorithms; Humans; Models, Statistical; Randomized Controlled Trials as Topic / statistics & numerical data; Research Design; Selection Bias; Statistics, Nonparametric
TL;DR:
It is demonstrated that objective variable selection techniques combined with a semiparametric framework can identify key variables and lead to unbiased and efficient inference on the treatment effect and show its superior performance relative to that of existing methods.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 article
Why Statistics?
Davidian, M., & Louis, T. A. (2012, April 6). SCIENCE, Vol. 336, pp. 12–12.
MeSH headings : Biostatistics; Data Interpretation, Statistical; Education, Graduate; Statistics as Topic / education; Workforce
UN Sustainable Development Goal Categories
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
A Moment-Adjusted Imputation Method for Measurement Error Models
BIOMETRICS, 67(4), 1461–1470.
author keywords: Conditional score; Measurement error; Nonlinear models; Regression calibration
MeSH headings : Algorithms; Blood Pressure Determination / methods; Computer Simulation; Data Interpretation, Statistical; Heart Failure / diagnosis; Heart Failure / epidemiology; Humans; Models, Statistical; Reproducibility of Results; Sensitivity and Specificity
TL;DR:
An imputation approach called moment‐adjusted imputation that is flexible and relatively automatic that can be used to adjust a variety of analyses quickly, and it performs well under a broad range of circumstances is proposed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Connections between survey calibration estimators and semiparametric models for incomplete data discussion
International Statistical Review, 79(2), 221–223.
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
Doubly Robust Estimation of Causal Effects
AMERICAN JOURNAL OF EPIDEMIOLOGY, 173(7), 761–767.
author keywords: causal inference; epidemiologic methods; propensity score
MeSH headings : Causality; Computer Simulation; Confidence Intervals; Confounding Factors, Epidemiologic; Epidemiologic Methods; Humans; Likelihood Functions; Models, Statistical; Monte Carlo Method; Propensity Score; Regression Analysis
TL;DR:
The authors present a conceptual overview of doubly robust estimation, a simple worked example, results from a simulation study examining performance of estimated and bootstrapped standard errors, and a discussion of the potential advantages and limitations of this method.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Improved Doubly Robust Estimation When Data Are Monotonely Coarsened, with Application to Longitudinal Studies with Dropout
BIOMETRICS, 67(2), 536–545.
author keywords: Coarsening at random; Discrete hazard; Dropout; Longitudinal data; Missing at random
MeSH headings : Acquired Immunodeficiency Syndrome; Biometry / methods; Computer Simulation; Humans; Longitudinal Studies; Models, Statistical; Statistical Distributions
TL;DR:
This work proposes a DR estimator applicable in general monotone coarsening problems that achieves comparable or improved performance relative to existing DR methods, which is demonstrated via simulation studies and by application to data from an AIDS clinical trial.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Inference on treatment effects from a randomized clinical trial in the presence of premature treatment discontinuation: the SYNERGY trial
BIOSTATISTICS, 12(2), 258–269.
author keywords: Dynamic treatment regime; Inverse probability weighting; Potential outcomes; Proportional hazards model
MeSH headings : Acute Coronary Syndrome / drug therapy; Algorithms; Computer Simulation; Endpoint Determination; Enoxaparin / administration & dosage; Enoxaparin / adverse effects; Enoxaparin / therapeutic use; Hemorrhage / etiology; Heparin / administration & dosage; Heparin / adverse effects; Heparin / therapeutic use; Humans; Intention to Treat Analysis; Models, Statistical; Monte Carlo Method; Mortality; Multicenter Studies as Topic; Probability; Proportional Hazards Models; Randomized Controlled Trials as Topic / methods; Survival Analysis; Treatment Outcome; Withholding Treatment / statistics & numerical data
TL;DR:
The Superior Yield of the New Strategy of Enoxaparin, Revascularization, and GlYcoprotein IIb/IIIa inhibitors (SYNERGY) was a randomized, open-label, multicenter clinical trial comparing 2 anticoagulant drugs on the basis of time-to-event endpoints.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Timing of HAART initiation and clinical outcomes in human immunodeficiency virus type 1 seroconverters
Archives of Internal Medicine, 171(17), 1560–1569.
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
Demographic and Historical Findings, Including Exposure to Environmental Tobacco Smoke, in Dogs with Chronic Cough
JOURNAL OF VETERINARY INTERNAL MEDICINE, 24(4), 825–831.
author keywords: Bronchitis; Environmental tobacco smoke; Respiratory tract; Tracheobronchomalacia
MeSH headings : Air Pollution, Indoor / adverse effects; Animals; Chronic Disease; Cough / chemically induced; Cough / veterinary; Dog Diseases / chemically induced; Dog Diseases / diagnosis; Dogs; Female; Male; Risk Factors; Tobacco Smoke Pollution / adverse effects
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 chapter
Doubly robust estimation of treatment effects
In D. Faries, A. Leon, J. M. Haro, & R. Obenchain (Eds.), Analysis of Observational Health-Care Data Using SAS. Cary, NC: SAS Press.
Ed(s): D. Faries, A. Leon, J. Haro & R. Obenchain
Source: NC State University Libraries
Added: January 27, 2020
2010 chapter
Experimental Statistics for biological sciences
In H. Bang, X. K. Zhou, H. L. Van Epps, & M. Mazumdar (Eds.), Statistical Methods in Molecular Biology (pp. 3–104). New York: Springer (Humana Press).
Ed(s): H. Bang, X. Zhou, H. Van Epps & M. Mazumdar
Source: NC State University Libraries
Added: January 27, 2020
2009 journal article
A model for HCMV infection in immunosuppressed patients
MATHEMATICAL AND COMPUTER MODELLING, 49(7-8), 1653–1663.
author keywords: HCMV; CMV; Herpes; Transplantation; Mathematical model; Immunosuppression
TL;DR:
Simulations with the approximated parameter values demonstrates that the model is capable of describing primary, latent, and secondary (reactivated) HCMV infection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 chapter
An Inverse Problem Statistical Methodology Summary
In Mathematical and Statistical Estimation Approaches in Epidemiology (pp. 249–302).
Sources: Crossref, NC State University Libraries
Added: January 23, 2020
2009 journal article
Gene-Trait Similarity Regression for Multimarker-Based Association Analysis
Biometrics, 65(3), 822–832.
MeSH headings : Chromosome Mapping / methods; Computer Simulation; Genetic Linkage / genetics; Genetic Markers / genetics; Haplotypes / genetics; Humans; Models, Genetic; Models, Statistical; Quantitative Trait Loci / genetics; Regression Analysis
TL;DR:
The proposed similarity‐based regression method to detect associations between traits and multimarker genotypes allows for covariates, uses phase‐independent similarity measures to bypass the needs to impute phase information, and is applicable to traits of general types.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, NC State University Libraries, Crossref
Added: August 6, 2018
2009 journal article
Improving efficiency and robustness of the doubly robust estimator for a population mean with incomplete data
BIOMETRIKA, 96(3), 723–734.
author keywords: Causal inference; Enhanced propensity score model; Missing at random; No unmeasured confounders; Outcome regression
TL;DR:
This work proposes alternative doubly robust estimators that achieve comparable or improved performance relative to existing methods, even with some estimated propensity scores close to zero.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Latent-Model Robustness in Joint Models for a Primary Endpoint and a Longitudinal Process
BIOMETRICS, 65(3), 719–727.
author keywords: Censoring; Random effect; Remeasurement method; SIMEX
MeSH headings : Biometry / methods; Clinical Trials as Topic; Computer Simulation; Data Interpretation, Statistical; Effect Modifier, Epidemiologic; Endpoint Determination / methods; Longitudinal Studies; Models, Statistical; Regression Analysis
TL;DR:
Methods to diagnose random effect model misspecification of the type that leads to biased inference on joint models are presented and illustrated via application to simulated data.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Nonlinear Models for Longitudinal Data
AMERICAN STATISTICIAN, 63(4), 378–388.
author keywords: Conditional model; Marginal model; Random-effects model; Serial correlation; Transition model
TL;DR:
All three main modeling families, marginal models, random-effects models, and conditional models are considered, exemplify their great flexibility and relative ease of use, and apply them to a simple but illustrative set of data on tree circumference growth of orange trees.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 journal article
"Smooth" semiparametric regression analysis for arbitrarily censored time-to-event data
BIOMETRICS, 64(2), 567–576.
author keywords: accelerated failure time model; heteroscedasticity; information criteria; interval censoring; proportional hazards model; proportional odds model; seminonparametric (SNP) density; time-dependent covariates
MeSH headings : Biometry / methods; Computer Simulation; Data Interpretation, Statistical; Models, Statistical; Regression Analysis; Statistics, Nonparametric
TL;DR:
A general framework for regression analysis of time-to-event data subject to arbitrary patterns of censoring is proposed, which allows popular models, such as the proportional hazards, proportional odds, and accelerated failure time models, to be placed in a common framework and provides a principled basis for choosing among them.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 journal article
'Smooth' inference for survival functions with arbitrarily censored data
Statistics in Medicine, 27(26), 5421–5439.
MeSH headings : Clinical Trials as Topic / methods; Computer Simulation; Data Interpretation, Statistical; Disease Progression; Endpoint Determination; Humans; Likelihood Functions; Statistics, Nonparametric; Survival Analysis
TL;DR:
The method is predicated on the mild assumption that the distribution of the random variable has a density that lies in a class of 'smooth' densities whose elements can be represented by an infinite Hermite series, and can result in gains in efficiency over traditional nonparametric methods.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2008 article
Covariate adjustment for two-sample treatment comparisons in randomized clinical trials: A principled yet flexible approach
Tsiatis, A. A., Davidian, M., Zhang, M., & Lu, X. (2008, October 15). STATISTICS IN MEDICINE, Vol. 27, pp. 4658–4677.
author keywords: baseline variables; clinical trials; covariate adjustment; efficiency; semiparametric theory; variable selection
MeSH headings : Algorithms; Data Interpretation, Statistical; Humans; Randomized Controlled Trials as Topic / statistics & numerical data; Sampling Studies; Statistics, Nonparametric; Treatment Outcome
TL;DR:
App appealing to the theory of semiparametrics is led naturally to a characterization of all treatment effect estimators and to principled, practically feasible methods for covariate adjustment that yield the desired gains in efficiency and that allow covariate relationships to be identified and exploited while circumventing the usual concerns.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 journal article
Improving efficiency of inferences in randomized clinical trials using auxiliary covariates
BIOMETRICS, 64(3), 707–715.
author keywords: covariate adjustment; hypothesis test; k-arm trial; Kruskal-Wallis test; log odds ratio; longitudinal data; semiparametric theory
MeSH headings : Acquired Immunodeficiency Syndrome / drug therapy; Analysis of Variance; Angina, Unstable / blood; Angina, Unstable / drug therapy; Anti-HIV Agents / therapeutic use; Anticoagulants / therapeutic use; Biometry / methods; Humans; Linear Models; Logistic Models; Models, Statistical; Monte Carlo Method; Odds Ratio; Platelet Glycoprotein GPIIb-IIIa Complex / metabolism; Randomized Controlled Trials as Topic / statistics & numerical data; Treatment Outcome
TL;DR:
Taking a semiparametric theory perspective, this work proposes a broadly applicable approach to adjustment for auxiliary covariates to achieve more efficient estimators and tests for treatment parameters in the analysis of randomized clinical trials.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 chapter
Joint models for longitudinal data
In Chapman & Hall/CRC Handbooks of Modern Statistical Methods (pp. 319–326).
Sources: Crossref, NC State University Libraries
Added: January 23, 2020
2008 book
TL;DR:
This course treats the statistical basis and practical application of linear Models for longitudinal normal data and generalized linear models for longitudinal binary, count, and ordinal data and involves inclusion of random effects in linear models to reflect within-person cross-time correlation.
(via Semantic Scholar)
Source: Crossref
Added: January 23, 2020
2008 book
Longitudinal Data Analysis
In Chapman & Hall/CRC, Taylor & Francis Group. Boca Raton, FL: Chapman & Hall/CRC.
Event: at Boca Raton, FL
Source: ORCID
Added: March 29, 2023
2008 journal article
Modelling HIV immune response and validation with clinical data
Journal of Biological Dynamics, 2(4), 357–385.
MeSH headings : CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / virology; HIV / immunology; HIV Antigens / immunology; HIV Infections / drug therapy; HIV Infections / immunology; HIV Infections / virology; Humans; Immunity / immunology; Models, Immunological; Reproducibility of Results; Viral Load / immunology; Viremia / immunology; Virus Activation / immunology
TL;DR:
This more biologically detailed model can exhibit the phenomenon of transient viremia experienced by some patients on therapy with viral load levels suppressed below the detection limit, and it is shown that treatment to move from a high viral load equilibrium state to an equilibrium state with a lower viral load is not possible for these patients.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 23, 2020
2008 chapter
Non-linear mixed-effects models
In Chapman & Hall/CRC Handbooks of Modern Statistical Methods (pp. 107–141).
Sources: Crossref, NC State University Libraries
Added: January 19, 2020
2007 journal article
Comment: Demystifying Double Robustness: A Comparison of Alternative Strategies for Estimating a Population Mean from Incomplete Data
Statistical Science, 22(4), 569–573.
TL;DR:
This discussion aims to complement the presentation of the authors by elaborating on the view from the vantage point of semi-parametric theory, focusing on the assumptions embedded in the statistical models leading to different “types” of estimators rather than on the forms of the estimators themselves.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 24, 2020
2007 journal article
Estimation and prediction with HIV-treatment interruption data
BULLETIN OF MATHEMATICAL BIOLOGY, 69(2), 563–584.
author keywords: HIV models; treatment interruptions; censored data; parameter estimation; prediction
MeSH headings : Antiretroviral Therapy, Highly Active / methods; CD4 Lymphocyte Count; Cohort Studies; Data Interpretation, Statistical; Drug Administration Schedule; HIV Infections / drug therapy; HIV Infections / immunology; HIV-1; Humans; Longitudinal Studies; Models, Biological; Predictive Value of Tests; Viral Load
TL;DR:
This work uses a nonlinear dynamical mathematical model in attempts to fit individual patient data for HIV patients undergoing treatment interruptions using a statistically-based censored data method and inverse problem techniques to estimate dynamic parameters.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2007 journal article
Likelihood and pseudo-likelihood methods for semiparametric joint models for a primary endpoint and longitudinal data
Computational Statistics & Data Analysis, 51(12), 5776–5790.
author keywords: conditional score; generalized linear model; mixed effects model; pseudo-likelihood; seminonparametric density
TL;DR:
A semiparametric joint model is considered that makes only mild assumptions on this distribution and likelihood-based inference on the association and distribution is developed, which offers improved performance relative to existing methods that is insensitive to the true random effects distribution.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2007 journal article
Using mathematical modeling and control to develop structured treatment interruption strategies for HIV infection
DRUG AND ALCOHOL DEPENDENCE, 88, S41–S51.
author keywords: STI; CD4; HIV dynamics; drug resistance; viral load
MeSH headings : CD4 Antigens / immunology; HIV Infections / drug therapy; HIV Infections / immunology; Humans; Models, Theoretical
TL;DR:
It is argued that the most promising STI strategies are adaptive treatment strategies, which involve cycles of treatment withdrawal and re-initiation and that, when such mathematical representations of processes underlying a disease or disorder are available, they can be an important tool for suggesting adaptive treatment Strategies for clinical study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2006 entry reference
Dose Calibration
Sources: Crossref, NC State University Libraries
Added: January 24, 2020
2006 journal article
Latent-model robustness in structural measurement error models
BIOMETRIKA, 93(1), 53–64.
author keywords: bias; latent variable; measurement error; remeasurement method; simulation extrapolation; structural modelling
TL;DR:
Methods for diagnosing the effects of model misspecification of the true-predictor distribution in structural measurement error models and practical techniques for examining the adequacy of an assumed latent predictor model are presented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2006 journal article
Smoothing spline-based score tests for proportional hazards models
BIOMETRICS, 62(3), 803–812.
author keywords: Cox model; penalized partial likelihood; smoothing parameter; variance component
MeSH headings : Analysis of Variance; Biometry / methods; Breast Neoplasms / drug therapy; Breast Neoplasms / metabolism; Clinical Trials as Topic / statistics & numerical data; Female; Humans; Likelihood Functions; Menopause; Proportional Hazards Models; Receptors, Estrogen / metabolism
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2005 entry reference
Biometrics
Sources: Crossref, NC State University Libraries
Added: January 24, 2020
2005 journal article
HIV dynamics: Modeling, data analysis, and optimal treatment protocols
JOURNAL OF COMPUTATIONAL AND APPLIED MATHEMATICS, 184(1), 10–49.
author keywords: HIV models; parameter estimation; data and model reduction; structured treatment interruptions; optimal control
TL;DR:
An overview of some concepts and methodologies useful in modeling HIV pathogenesis including parameter estimation, data reduction and representation, and optimal control relative to STI are presented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2005 journal article
Semiparametric estimation of treatment effect in a pretest-posttest study with missing data
Statistical Science, 20(3), 261–282.
Source: NC State University Libraries
Added: August 6, 2018
2005 article
Statistical issues arising in the Women's Health Initiative - Discussion
Tsiatis, A. A., & Davidian, M. (2005, December). BIOMETRICS, Vol. 61, pp. 933–935.
TL;DR:
The evidence clearly supports a clinically important protection against heart disease for postmenopausal women who use estrogen, and this topic seems important in resolving the discrepancy between WHI clinical trial and observational study results on post menopausal hormone therapy and cardiovascular disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2005 journal article
Surgeons? Economic Profiles: Can We Get the ?Right? Answers?
Journal of Medical Systems, 29(2), 111–124.
MeSH headings : Aged; Benchmarking / methods; Cardiology Service, Hospital / economics; Cohort Studies; Coronary Artery Bypass / economics; Coronary Artery Bypass / mortality; Costs and Cost Analysis; Data Interpretation, Statistical; Female; Health Services Research / methods; Hospital Bed Capacity, 500 and over; Humans; Male; Middle Aged; Models, Economic; Practice Patterns, Physicians' / economics; Reproducibility of Results; Risk; Treatment Outcome
TL;DR:
It is found that profiles reporting unadjusted average surgeon costs may incorrectly identify high- and low-cost outliers, demonstrating the need for hospitals to reexamine their economic profiling methods.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 24, 2020
2004 journal article
Conditional estimation for generalized linear models when covariates are subject-specific parameters in a mixed model for longitudinal measurements
Biometrics, 60(1), 07-.
Source: NC State University Libraries
Added: August 6, 2018
2004 journal article
Differential Treatment Benefit of Platelet Glycoprotein IIb/IIIa Inhibition With Percutaneous Coronary Intervention Versus Medical Therapy for Acute Coronary Syndromes
Circulation, 109(5), 641–646.
author keywords: trials; glycoproteins; coronary disease
MeSH headings : Acute Disease; Aged; Combined Modality Therapy; Coronary Disease / drug therapy; Coronary Disease / surgery; Female; Humans; Male; Middle Aged; Myocardial Revascularization; Patient Selection; Platelet Glycoprotein GPIIb-IIIa Complex / antagonists & inhibitors; Randomized Controlled Trials as Topic; Research Design; Syndrome; Treatment Outcome
TL;DR:
Clinical-practice decisions and practice guidelines should be based on overall trial results and not analyses of post-randomization subgroups, based primarily on inappropriate subgroup analyses performed across the glycoprotein IIb/IIIa inhibitor trials.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018
2004 journal article
Discussion of nonparametric and semiparametric regression
Statistica Sinica, 14(3), 615–629.
Source: NC State University Libraries
Added: August 6, 2018
2004 journal article
Emerging issues in longitudinal and functional data analysis - Introduction
Statistica Sinica, 14(3), 613–614.
Source: NC State University Libraries
Added: August 6, 2018
2004 journal article
Growth, mortality, and hatchdate distributions of larval and juvenile spotted seatrout (Cynoscion nebulosus) in Florida Bay, Everglades National Park
Fishery Bulletin (Washington, D.C.), 102(1), 142–155.
Source: NC State University Libraries
Added: August 6, 2018
2004 journal article
Joint modeling of longitudinal and time-to-event data: An overview
Statistica Sinica, 14(3), 809–834. http://www.jstor.org/stable/24307417
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
2004 journal article
Likelihood and conditional likelihood inference for generalized additive mixed models for clustered data
JOURNAL OF MULTIVARIATE ANALYSIS, 91(1), 90–106.
author keywords: longitudinal data; marginal likelihood; nonparametric regression; smoothing spline; variance component
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2004 chapter
Linear mixed effects models with flexible generalized skew-elliptical random effects
In Skew-elliptical distibutions and their applications: A journey beyond normality. Boca Raton, FL: Chapman & Hall/CRC.
Source: NC State University Libraries
Added: August 6, 2018
2004 journal article
Marginal structural models for analyzing causal effects of time-dependent treatments: An application in perinatal epidemiology
AMERICAN JOURNAL OF EPIDEMIOLOGY, 159(10), 926–934.
author keywords: causality; confounding factors (epidemiology); epidemiologic methods; longitudinal studies; models, structural
MeSH headings : Adult; Anemia / diet therapy; Anemia / epidemiology; Anemia / prevention & control; Causality; Confounding Factors, Epidemiologic; Dietary Supplements; Epidemiologic Research Design; Female; Humans; Iron / administration & dosage; Logistic Models; Models, Statistical; North Carolina / epidemiology; Pregnancy; Pregnancy Complications, Hematologic / diet therapy; Pregnancy Complications, Hematologic / epidemiology; Pregnancy Complications, Hematologic / prevention & control; Random Allocation; Time Factors
TL;DR:
The objective of this paper is to illustrate the fitting of an MSM for the causal effect of iron supplement use during pregnancy (time-varying treatment) on odds of anemia at delivery in the presence of time-dependent confounding.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2004 journal article
Stratification and weighting via the propensity score in estimation of causal treatment effects: a comparative study
STATISTICS IN MEDICINE, 23(19), 2937–2960.
author keywords: covariate balance; double robustness; inverse-probability-of-treatment-weighted-estimator; observational data
MeSH headings : Computer Simulation; Data Interpretation, Statistical; Humans; Monte Carlo Method; Regression Analysis; Treatment Outcome
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2003 journal article
Nonlinear models for repeated measurement data: An overview and update
JOURNAL OF AGRICULTURAL BIOLOGICAL AND ENVIRONMENTAL STATISTICS, 8(4), 387–419.
author keywords: hierarchical model; inter-individual variation; intra-individual variation; nonlinear mixed effects model; random effects; serial correlation; subject-specific
TL;DR:
An overview of the formulation, interpretation, and implementation of nonlinear mixed effects models and surveys recent advances and applications is presented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2003 journal article
Robust two-stage approach to repeated measurements analysis of chronic ozone exposure in rats
JOURNAL OF AGRICULTURAL BIOLOGICAL AND ENVIRONMENTAL STATISTICS, 8(4), 438–454.
author keywords: ANOVA; hierarchical nonlinear model; M-estimation; Michaelis-Menten; mixed effects; outlier
TL;DR:
A robust two-stage approach is used to reanalyze the repeated measurements from an experiment of airway responsiveness in rats randomized to long-term exposure at four ozone doses, finding the true effect of chronic ozone exposure may be masked by a few rats which exert undue influence on the population estimates in a nonrobust analysis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2003 journal article
Semiparametric estimation of treatment effect in a pretest-posttest study
BIOMETRICS, 59(4), 1046–1055.
author keywords: analysis of covariance; counterfactuals; influence function; inverse probability weighting; semiparametric model; t-test
MeSH headings : Antiviral Agents / therapeutic use; Biometry / methods; CD4 Lymphocyte Count; Clinical Trials as Topic; Computer Simulation; HIV Infections / drug therapy; Humans; Models, Statistical; Randomized Controlled Trials as Topic; Statistics, Nonparametric
TL;DR:
This work exploits recent developments in the literature on missing data and causal inference to derive the class of all consistent treatment effect estimators, identify the most efficient such estimator, and outline strategies for implementation of estimators that may improve on popular methods.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2002 journal article
A Monte Carlo EM algorithm for generalized linear mixed models with flexible random effects distribution.
Biostatistics (Oxford, England), 3(3), 347–360.
author keywords: correlated data; rejection sampling; seminonparametric density; semiparametric mixed model
TL;DR:
A Monte Carlo EM algorithm using a rejection sampling scheme to estimate the fixed parameters of the linear predictor, variance components and the SNP density is proposed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2002 journal article
A semiparametric likelihood approach to joint modeling of longitudinal and time-to-event data
BIOMETRICS, 58(4), 742–753.
author keywords: informative censoring; mixed model; proportional hazards; SNP density; survival
MeSH headings : Anti-HIV Agents / therapeutic use; Biometry / methods; Computer Simulation; Disease Progression; HIV Infections / drug therapy; Humans; Likelihood Functions; Longitudinal Studies; Monte Carlo Method; Proportional Hazards Models; Randomized Controlled Trials as Topic / methods
TL;DR:
This work proposes a likelihood-based approach that requires only the assumption that the random effects have a smooth density, and implementation via the EM algorithm is described, and performance and the benefits for uncovering noteworthy features are illustrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2002 journal article
An estimator for the proportional hazards model with multiple longitudinal covariates measured with error
Biostatistics (Oxford, England), 3(4), 511–528.
Source: NC State University Libraries
Added: August 6, 2018
2002 chapter
Constrained four parameter logistic model
In Developments in Biologicals: Vol. 107. The Design and Analysis of Potency Assays for Biotechnology Products (pp. 71–76). Basel: Karger.
Source: NC State University Libraries
Added: September 27, 2020
2002 journal article
Estimation of survival distributions of treatment policies in two-stage randomization designs in clinical trials
BIOMETRICS, 58(1), 48–57.
author keywords: induction therapy; intent to treat; inverse weighting; maintenance therapy; potential outcomes; survival analysis
MeSH headings : Aged; Computer Simulation; Granulocyte-Macrophage Colony-Stimulating Factor / therapeutic use; Humans; Leukemia, Myeloid, Acute / drug therapy; Models, Statistical; Randomized Controlled Trials as Topic / methods; Survival Analysis; Treatment Outcome
TL;DR:
It is proposed consistent estimators for the survival distribution and mean restricted survival time for each treatment policy in such two‐stage studies and derive large‐sample properties.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2002 journal article
Multiple imputation methods for testing treatment differences in survival distributions with missing cause of failure
Biometrika, 89(1), 238–244.
Source: NC State University Libraries
Added: August 6, 2018
2002 journal article
Randomized COMparison of platelet inhibition with abciximab, TiRofiban and eptifibatide during percutaneous coronary intervention in acute coronary syndromes - The COMPARE trial
Circulation (New York, N.Y. : 1950), 106(12), 1470–1476.
Source: NC State University Libraries
Added: August 6, 2018
2001 journal article
A semiparametric estimator for the proportional hazards model with longitudinal covariates measured with error
BIOMETRIKA, 88(2), 447–458.
author keywords: conditional score; measurement error; mixed effects model; regression calibration; semiparametric; survival analysis
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2001 journal article
Linear mixed models with flexible distributions of random effects for longitudinal data
BIOMETRICS, 57(3), 795–802.
author keywords: longitudinal data; multimodality; random effects; seminonparametric density; semiparametric mixed effects model; skewness
MeSH headings : Biometry; Cholesterol / blood; Data Interpretation, Statistical; Humans; Likelihood Functions; Linear Models; Longitudinal Studies
TL;DR:
It is demonstrated that standard information criteria may be used to choose the tuning parameter and detect departures from normality, and the approach is illustrated via simulation and using longitudinal data from the Framingham study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2001 journal article
Robust two-stage estimation in hierarchical nonlinear models
BIOMETRICS, 57(1), 266–272.
author keywords: M-estimation; mixed effects; outliers; repeated measurements
MeSH headings : Air Pollutants / toxicity; Algorithms; Animals; Biometry; Least-Squares Analysis; Nonlinear Dynamics; Ozone / toxicity; Rats; Respiratory System / drug effects; Serotonin / pharmacology
TL;DR:
This work proposes a robust two-stage procedure based on Huber's (1981, Robust Statistics) theory of M-estimation to accommodate separately aberrant responses within an experimental unit and subjects deviating from the study population when the usual assumptions of normality are violated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2000 journal article
Consequences of misspecifying assumptions in nonlinear mixed effects models
COMPUTATIONAL STATISTICS & DATA ANALYSIS, 34(2), 139–164.
author keywords: random effects; nonnormality; Laplace approximation; linearization
TL;DR:
The consequences for population inferences using popular methods for fitting nonlinear mixed effects models when the normality assumption is inappropriate and/or the model is misspecified are investigated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2000 journal article
Correcting for measurement error in individual-level covariates in nonlinear mixed effects models
BIOMETRICS, 56(2), 368–375.
author keywords: laplace's approximation; random effects; regression calibration; small sigma
MeSH headings : Biometry / methods; Calibration; Models, Statistical; Pharmacokinetics; Regression Analysis; Virus Physiological Phenomena
TL;DR:
Methods to take account of measurement error that correct this bias are developed and may be implemented with standard software and demonstrated their utility via simulation and application to data from a study of HIV dynamics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2000 article
Differences in viral dynamics between genotypes 1 and 2 of hepatitis C virus
Neumann, A. U., Lam, N. P., Dahari, H., Davidian, M., Wiley, T. E., Mika, B. P., … Layden, T. J. (2000, July). JOURNAL OF INFECTIOUS DISEASES, Vol. 182, pp. 28–35.
MeSH headings : Antiviral Agents / therapeutic use; Apoptosis; Female; Genotype; Hepacivirus / genetics; Hepacivirus / physiology; Hepatitis C / drug therapy; Hepatitis C / immunology; Hepatitis C / pathology; Hepatitis C / virology; Humans; Interferon-alpha / therapeutic use; Male; Metabolic Clearance Rate; Middle Aged; Models, Theoretical; RNA, Viral / metabolism
TL;DR:
The better response rate of patients infected with HCV genotype 2 is multifactorial, the first finding of a difference in viral dynamics between subtypes of the same virus and demonstrates the importance of subtype-specific virus-host-drug interactions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2000 journal article
Estimating data transformations in nonlinear mixed effects models
BIOMETRICS, 56(1), 65–72.
author keywords: Laplace's approximation; nonlinear mixed effects model; random effects; repeated measurements; small sigma; transform both sides
MeSH headings : Arginine / analogs & derivatives; Biometry / methods; Data Interpretation, Statistical; Humans; Infant, Newborn; Infant, Premature; Likelihood Functions; Monte Carlo Method; Nonlinear Dynamics; Phenobarbital / pharmacokinetics; Pipecolic Acids / pharmacokinetics; Sulfonamides
TL;DR:
A mixed effects framework based on the transform‐both‐sides model, where the transformation is represented by a monotone parametric function and is estimated from the data, is proposed, allowing straightforward implementation via standard software.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1999 journal article
Human immunodeficiency virus type 1-specific cytotoxic T lymphocyte activity is inversely correlated with HIV type 1 viral load in HIV type 1-infected long-term survivors
AIDS RESEARCH AND HUMAN RETROVIRUSES, 15(13), 1219–1228.
MeSH headings : CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes / immunology; Cross-Sectional Studies; Cytotoxicity Tests, Immunologic; Gene Products, pol / genetics; Gene Products, pol / metabolism; HIV Infections / immunology; HIV Infections / virology; HIV Long-Term Survivors; HIV-1 / immunology; HIV-1 / physiology; Histocompatibility Antigens Class I / classification; Histocompatibility Antigens Class I / genetics; Histocompatibility Antigens Class I / immunology; Humans; Longitudinal Studies; Male; Receptors, CCR5 / genetics; T-Lymphocytes, Cytotoxic / immunology; Viral Load
TL;DR:
The data suggest that the presence of HIV- 1-specific CTL activity in HIV-1-infected long-term survivors is an important component in the effective control of HIV -1 replication.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1999 chapter
Invited discussion of “The Bayesian approach to population pharmacokinetic-pharmacodynamic modeling” by Wakefield, Aarons, and Racine-Poon
In C. Gatsonis, R. E. Kass, B. Carlin, A. Carriquiry, A. Gelman, I. Verdinelli, & M. West (Eds.), Case Studies in Bayesian Statistics: Vol. IV (pp. 257–263). New York: Springer-Verlag.
Ed(s): C. Gatsonis, R. Kass, B. Carlin, A. Carriquiry, A. Gelman, I. Verdinelli, M. West
Source: NC State University Libraries
Added: September 27, 2020
1998 journal article
Estimating the parameters in the Cox model when covariate variables are measured with error
BIOMETRICS, 54(4), 1407–1419.
author keywords: cumulative hazards; measurement error; nonparametric maximum likelihood; proportional hazards model; regression calibration; semiparametric method
TL;DR:
A likelihood-based approach is introduced, which is referred to as the semiparametric method, and it is shown that this method is an appealing alternative to the Cox proportional hazards model to analyze the relationship between survival and CD4 count in patients with AIDS.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1998 journal article
Statistical properties of fitted estimates of apparent in vivo metabolic constants obtained from gas uptake data. I. Lipophilic and slowly metabolized VOCs
Inhalation Toxicology, 10(5), 383–409.
Source: NC State University Libraries
Added: August 6, 2018
1998 journal article
The effect of serial dilution error on calibration inference in immunoassay
BIOMETRICS, 54(1), 19–32.
author keywords: confidence intervals; ELISA; generalized least squares; measurement error; precision profile; variance function estimation
TL;DR:
It is demonstrated that failure to account for serial dilution error in calibration inference on unknown samples leads to serious inaccuracy of assessments of assay precision such as confidence intervals and precision profiles.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1997 journal article
A two-step approach to measurement error in time-dependent covariates in nonlinear mixed-effects models, with application to IGF-I pharmacokinetics
Journal of the American Statistical Association, 92(438), 436–448.
TL;DR:
Data is considered from a study of insulin-like growth factor I administered by intravenous infusion to patients with severe head trauma to identify individual-specific covariates associated with pharmacokinetic behavior.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
1997 journal article
Bootstrap-Adjusted Calibration Confidence Intervals for Immunoassay
Journal of the American Statistical Association, 92(437), 278–290.
TL;DR:
This work proposes a bootstrap procedure to adjust the usual intervals to achieve a higher degree of accuracy in immunoassay, and provides both theoretical results and simulation evidence to show that the proposed method attains the nominal level.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 24, 2020
1997 journal article
Calibration inference based on multiple runs of an immunoassay
BIOMETRICS, 53(4), 1304–1317.
author keywords: confidence interval; empirical Bayes; nonlinear mixed effects; pooled variance estimation
TL;DR:
Methods for combining information from multiple runs to estimate assay response variance parameters and to refine characterization of the standard curve for the current run via empirical Bayes techniques are investigated formally.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
2. Zero Hunger
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1997 journal article
Testing homogeneity of intra-run variance parameters in immunoassay
STATISTICS IN MEDICINE, 16(15), 1765–1776.
TL;DR:
A simple procedure is proposed for a formal test of the assumption of the homogeneity of parameters that characterize intra-run variation based on representation of standard curve data from multiple assay runs by a non-linear mixed effects model and the robustness of calibration inference to incorrect assumptions about the pattern of intra- run variation is investigated.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1996 journal article
A note on covariate measurement error in nonlinear mixed effects models
Biometrika, 83(4), 801–812.
author keywords: controlled variable model; generalised least squares; small sigma; two-stage estimation; variance function estimation
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020
1996 journal article
Denaturation and Aggregation of Chicken Myosin Isoforms
Journal of Agricultural and Food Chemistry, 44(6), 1435–1440.
author keywords: myosin; aggregation; denaturation; muscle protein
TL;DR:
Heat-induced denaturation and aggregation of chicken myosins isolated from one white muscle (pectoralis) and two red muscles (iliotibialis and gastrocnemius) were investigated using differential scanning calorimetry and turbidity measurements.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 24, 2020
1996 journal article
Organic Matter Decomposition following Harvesting and Site Preparation of a Forested Wetland
Soil Science Society of America Journal, 60(6), 1994–2003.
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 24, 2020
1996 journal article
Pyrimethamine pharmacokinetics in human immunodeficiency virus-positive patients seropositive for Toxoplasma gondii.
Antimicrobial Agents and Chemotherapy, 40(6), 1360–1365.
MeSH headings : AIDS-Related Opportunistic Infections / drug therapy; AIDS-Related Opportunistic Infections / metabolism; Drug Interactions; HIV Infections / drug therapy; HIV Infections / metabolism; Half-Life; Humans; Male; Pyrimethamine / adverse effects; Pyrimethamine / pharmacokinetics; Toxoplasmosis / drug therapy; Toxoplasmosis / metabolism; Zidovudine / pharmacokinetics; Zidovudine / therapeutic use
TL;DR:
Pyrimethamine exhibited pharmacokinetics in HIV-infected patients that were similar to those in non-HIV- infected subjects and it did not alter the pharmacokinetic of zidovudine in these patients.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 24, 2020
1996 journal article
The Effect of Variance Function Estimation on Nonlinear Calibration Inference in Immunoassay Data
Biometrics, 52(1), 158.
author keywords: assay; confidence interval; generalized least squares; heteroscedasticity; variance function estimation
TL;DR:
Calibration inference for immunoassay data which exhibit this nonlinear heteroscedastic mean-variance relationship is discussed, and an assessment of the effect of variance function estimation in three types of approximate large-sample confidence intervals for unknown concentrations is given.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 24, 2020
1995 book
Nonlinear models for repeated measurement data
In Chapman & Hall/CRC. Boca Raton, FL: Boca Raton: Chapman & Hall.
Event: at Boca Raton, FL
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
1995 journal article
Therapeutic effects of diethylcarbamazine and 3′-azido-3′-deoxythymidine on feline leukemia virus lymphoma formation
Veterinary Immunology and Immunopathology, 46(1-2), 181–194.
MeSH headings : Animals; Antibodies, Viral / blood; Cat Diseases / drug therapy; Cat Diseases / immunology; Cats; Diethylcarbamazine / administration & dosage; Diethylcarbamazine / therapeutic use; Enzyme-Linked Immunosorbent Assay / veterinary; Flow Cytometry / veterinary; Gene Products, gag / immunology; Leukemia Virus, Feline / drug effects; Leukemia Virus, Feline / immunology; Leukocyte Count / veterinary; Leukopenia / drug therapy; Leukopenia / immunology; Lymphocytes / immunology; Lymphoma / drug therapy; Lymphoma / immunology; Lymphoma / veterinary; Random Allocation; Retroviridae Infections / drug therapy; Retroviridae Infections / immunology; Retroviridae Infections / veterinary; Retroviridae Proteins, Oncogenic / immunology; Specific Pathogen-Free Organisms; Survival Rate; Tumor Virus Infections / drug therapy; Tumor Virus Infections / immunology; Tumor Virus Infections / veterinary; Viral Envelope Proteins / immunology; Zidovudine / administration & dosage; Zidovudine / therapeutic use
TL;DR:
DEC as well as AZT therapy delays the development of lymphomas associated with FeLV infection and significantly improves survival, suggesting FeLVR-induced immunosuppression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018
1994 journal article
Assays for recombinant proteins: A problem in non-linear calibration
Statistics in Medicine, 13(11), 1165–1179.
MeSH headings : Bayes Theorem; Biological Assay / methods; Biological Assay / standards; Biological Assay / statistics & numerical data; Calibration; Humans; Likelihood Functions; Models, Biological; Nonlinear Dynamics; Recombinant Proteins / blood; Regression Analysis; Reproducibility of Results
TL;DR:
It is shown that proper characterization of intra-assay variability requires pooling of information across several assay runs, and that use of empirical Bayes methods in calibration may afford considerable gain in efficiency.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: January 24, 2020
1994 journal article
Low serum antibacterial activity coincides with increased prevalence of shell disease in blue crabs Callinectes sapidus
Diseases of Aquatic Organisms, 19(2), 121–128.
author keywords: INVERTEBRATE IMMUNITY; BACTERICIDINS; BACTERIAL DISEASE
TL;DR:
In commercially important blue crabs Callinectes sapidus from the Albemarle-Pamlico Estuary, North Carolina, USA, potent antibacterial activity was identified which was active against most of the bacteria inhabiting the shell of both clinically normal crabs as well as those with shell disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018
1994 journal article
Population Pharmacokinetic/Pharmacodynamic Methodology and Applications: A Bibliography
Biometrics, 50(2), 566.
author keywords: NONLINEAR MIXED EFFECTS MODEL; POPULATION PHARMACOKINETICS/PHARMACODYNAMICS
TL;DR:
This bibliography lists all published methodological works (statistical methodology, implementation methodology, review papers, descriptions of software) in the area of population pharmacokinetics/pharmacodynamics up to 1993 and all published works describing applications of population pharmaceuticals up to 1992.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: January 24, 2020
1993 journal article
Analysis of repeated measurement data using the nonlinear mixed effects model
Chemometrics and Intelligent Laboratory Systems, 20(1), 1–24.
TL;DR:
In this tutorial, the NME model has been used to describe repeated measurement data for which the mean response function is nonlinear, and several methods are given for estimation and inference in the context of the model.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 24, 2020
1993 journal article
Some Simple Methods for Estimating Intraindividual Variability in Nonlinear Mixed Effects Models
Biometrics, 49(1), 59.
author keywords: CALIBRATION; GENERALIZED LEAST SQUARES; HETEROSCEDASTICITY; INTEREXPERIMENT VARIABILITY; PHARMACOKINETICS; VARIANCE FUNCTION ESTIMATION
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: January 24, 2020
1993 journal article
Some general estimation methods for nonlinear mixed-effects model
Journal of Biopharmaceutical Statistics, 3(1), 23–55.
MeSH headings : Calibration; Computer Simulation; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Female; Humans; Least-Squares Analysis; Likelihood Functions; Models, Biological; Models, Statistical; Relaxin / pharmacology; Software; Soybeans / growth & development
TL;DR:
A nonlinear mixed-effects model suitable for characterizing repeated measurement data and two classes of procedures for estimation in this model are described, which incorporate estimation of unknown parameters in the assumed intraindividual covariance structure.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 24, 2020
1993 journal article
The nonlinear mixed effects model with a smooth random effects density
Biometrika, 80(3), 475–488.
TL;DR:
The fixed parameters of the nonlinear mixed effects model and the density of the random effects are estimated jointly by maximum likelihood by using a series expansion that follows from the smoothness assumption to represent the density and quadrature to compute the likelihood.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 24, 2020
1992 journal article
Smooth nonparametric maximum likelihood estimation for population pharmacokinetics, with application to quinidine
Journal of Pharmacokinetics and Biopharmaceutics, 20(5), 529–556.
author keywords: POPULATION PHARMACOKINETICS; NONLINEAR MIXED EFFECTS MODELS; DENSITY ESTIMATION; NONPARAMETRIC ESTIMATION; MAXIMUM LIKELIHOOD; QUINIDINE
MeSH headings : Absorption; Bayes Theorem; Female; Genetic Variation / physiology; Humans; Male; Mathematical Computing; Methods; Models, Biological; Pharmacokinetics; Population; Quinidine / pharmacokinetics; Software
TL;DR:
The seminonparametric (SNP) method, popular in the econometrics literature, is proposed for use in population pharmacokinetic analysis and a graphical modelbuilding strategy based on the SNP method is described.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: January 24, 2020
1991 report
Infectious bursal disease virus titers may be misleading
In Breakthrough, North Carolina Cooperative Extension Service (Vol. 15).
Source: NC State University Libraries
Added: September 27, 2020
1991 conference paper
The use of regression analysis in nonwovens research
Proceedings of the TAPPI 1991 Nonwovens Conference, 27–33. Atlanta, Georgia: TAPPI Press.
Source: NC State University Libraries
Added: January 27, 2020
1990 journal article
Estimation of variance functions in assays with possibly unequal replication and nonnormal data
Biometrika, 77(1), 43–54.
TL;DR:
It is shown that ignoring unequal replication can lead to bias and inefficiency in estimation, and a method to account for bias is described that can offer robustness to nonnormality and leads to a comparison of Gini's mean difference to sample standard deviation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: January 24, 2020
1990 journal article
Regression and calibration with nonconstant error variance
Chemometrics and Intelligent Laboratory Systems, 9(3), 231–248.
Sources: Crossref, NC State University Libraries
Added: January 24, 2020
1988 journal article
A Note on Extended Quasi-Likelihood
Journal of the Royal Statistical Society: Series B (Methodological), 50(1), 74–82.
Sources: Crossref, NC State University Libraries
Added: January 24, 2020
1988 journal article
Variance functions and the minimum detectable concentration in assays
Biometrika, 75(3), 549–556.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: January 24, 2020
1987 journal article
VARIANCE FUNCTION ESTIMATION
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, 82(400), 1079–1091.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
Employment
Updated: November 3rd, 2019 14:47
1987 - present
North Carolina State University Raleigh, North Carolina, US
Professor
Statistics
Education
Updated: November 3rd, 2019 14:48
1982 - 1987
University of North Carolina at Chapel Hill Chapel Hill, NC, US
PhD
Statistics
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