@article{pacardo_neupane_rikard_lu_mo_mishra_tracy_wang_ligler_gu_2015, title={A dual wavelength-activatable gold nanorod complex for synergistic cancer treatment}, volume={7}, ISSN={["2040-3372"]}, url={http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000357805700034&KeyUID=WOS:000357805700034}, DOI={10.1039/c5nr01568e}, abstractNote={A multifunctional gold nanorod complex was formulated for synergistic anticancer treatment upon ultraviolet (UV) and infrared (IR) light dual irradiations.}, number={28}, journal={NANOSCALE}, author={Pacardo, Dennis B. and Neupane, Bhanu and Rikard, S. Michaela and Lu, Yue and Mo, Ran and Mishra, Sumeet R. and Tracy, Joseph B. and Wang, Gufeng and Ligler, Frances S. and Gu, Zhen}, year={2015}, pages={12096–12103} }
 @article{pacardo_neupane_wang_gu_walker_ligler_2015, title={A temperature microsensor for measuring laser-induced heating in gold nanorods}, volume={407}, ISSN={["1618-2650"]}, DOI={10.1007/s00216-014-8222-9}, number={3}, journal={ANALYTICAL AND BIOANALYTICAL CHEMISTRY}, author={Pacardo, Dennis B. and Neupane, Bhanu and Wang, Gufeng and Gu, Zhen and Walker, Glenn M. and Ligler, Frances S.}, year={2015}, month={Jan}, pages={719–725} }
 @misc{pacardo_ligler_gu_2015, title={Programmable nanomedicine: synergistic and sequential drug delivery systems}, volume={7}, ISSN={["2040-3372"]}, DOI={10.1039/c4nr07677j}, abstractNote={Recent developments in nanomedicine for the cancer therapy have enabled programmable delivery of therapeutics by exploiting the stimuli-responsive properties of nanocarriers. These therapeutic systems were designed with the relevant chemical and physical properties that respond to different triggers for enhanced anticancer efficacy, including the reduced development of drug-resistance, lower therapeutic dose, site-specific transport, and spatiotemporally controlled release. This minireview discusses the current advances in programmable nanocarriers for cancer therapy with particular emphasis on synergistic and sequential drug delivery systems.}, number={8}, journal={NANOSCALE}, author={Pacardo, Dennis B. and Ligler, Frances S. and Gu, Zhen}, year={2015}, pages={3381–3391} }
 @article{lu_hu_lin_pacardo_wang_sun_ligler_dickey_gu_2015, title={Transformable liquid-metal nanomedicine}, volume={6}, ISSN={["2041-1723"]}, DOI={10.1038/ncomms10066}, abstractNote={To date, numerous inorganic nanocarriers have been explored for drug delivery systems (DDSs). However, the clinical application of inorganic formulations has often been hindered by their toxicity and failure to biodegrade. We describe here a transformable liquid-metal nanomedicine, based on a core-shell nanosphere composed of a liquid-phase eutectic gallium-indium core and a thiolated polymeric shell. This formulation can be simply produced through a sonication-mediated method with bioconjugation flexibility. The resulting nanoparticles loaded with doxorubicin (Dox) have an average diameter of 107 nm and demonstrate the capability to fuse and subsequently degrade under a mildly acidic condition, which facilitates release of Dox in acidic endosomes after cellular internalization. Equipped with hyaluronic acid, a tumour-targeting ligand, this formulation displays enhanced chemotherapeutic inhibition towards the xenograft tumour-bearing mice. This liquid metal-based DDS with fusible and degradable behaviour under physiological conditions provides a new strategy for engineering theranostic agents with low toxicity.}, number={1}, journal={NATURE COMMUNICATIONS}, publisher={Springer Nature}, author={Lu, Yue and Hu, Quanyin and Lin, Yiliang and Pacardo, Dennis B. and Wang, Chao and Sun, Wujin and Ligler, Frances S. and Dickey, Michael D. and Gu, Zhen}, year={2015}, month={Dec} }
 @article{boyd_naciri_fontana_pacardo_shields_verbarg_spillmann_ligler_2014, title={Facile Fabrication of Color Tunable Film and Fiber Nanocomposites via Thiol Click Chemistry}, volume={47}, ISSN={["1520-5835"]}, DOI={10.1021/ma401636e}, abstractNote={A simple method for the fabrication of nanocomposite materials using thiol click chemistry is reported. The thiol click nanocomposite materials produced each displayed distinctive colors which were found to be dependent on both the ligand used to functionalize the nanoparticles and the concentration of nanoparticles in the materials. Functionalized metallic nanospheres were combined with thiol click solutions forming viscous prepolymer solutions which were then polymerized upon UV light exposure. Films were fabricated in a custom-built film mold, and microfibers were fabricated using hydrodynamic focusing in a microfluidic channel. For this study, three unique thiolated ligands—including a newly synthesized ligand—were used to functionalize the nanospheres, thus assisting in the facile incorporation and stability of the nanospheres within the polymers. In comparison to a previously reported method in which thiol–ene nanocomposite films were fabricated, the method reported herein reduces the fabrication ti...}, number={2}, journal={MACROMOLECULES}, author={Boyd, Darryl A. and Naciri, Jawad and Fontana, Jake and Pacardo, Dennis B. and Shields, Adam R. and Verbarg, Jasenka and Spillmann, Christopher M. and Ligler, Frances S.}, year={2014}, month={Jan}, pages={695–704} }
 @article{lu_mo_tai_sun_pacardo_qian_shen_ligler_gu_2014, title={Self-folded redox/acid dual-responsive nanocarriers for anticancer drug delivery}, volume={50}, ISSN={["1364-548X"]}, DOI={10.1039/c4cc07004f}, abstractNote={Self-folded redox/acid dual-responsive nanocarriers (RAD-NCs) are developed for physiologically triggered delivery of anticancer drugs. The evidenced redox/acid responsiveness, facile decoration of ligands, and active tumor-targeting capability of RAD-NCs suggest their potential as a promising formulation for tumor-targeted chemotherapy.}, number={95}, journal={CHEMICAL COMMUNICATIONS}, author={Lu, Yue and Mo, Ran and Tai, Wanyi and Sun, Wujin and Pacardo, Dennis B. and Qian, Chenggen and Shen, Qundong and Ligler, Frances S. and Gu, Zhen}, year={2014}, pages={15105–15108} }
 @article{boyd_bezares_pacardo_ukaegbu_hosten_ligler_2014, title={Small-Molecule Detection in Thiol-Yne Nanocomposites via Surface-Enhanced Raman Spectroscopy}, volume={86}, ISSN={["1520-6882"]}, DOI={10.1021/ac503607b}, abstractNote={Surface-enhanced Raman spectroscopy (SERS) is generally performed on planar surfaces, which can be difficult to prepare and may limit the interaction of the sensing surface with targets in large volume samples. We propose that nanocomposite materials can be configured that both include SERS probes and provide a high surface area-to-volume format, i.e., fibers. Thiol–yne nanocomposite films and fibers were fabricated using exposure to long-wave ultraviolet light after the inclusion of gold nanoparticles (AuNPs) functionalized with thiophenol. A SERS response was observed that was proportional to the aggregation of the AuNPs within the polymers and the amount of thiophenol present. Overall, this proof-of-concept fabrication of SERS active polymers indicated that thiol–yne nanocomposites may be useful as durable film or fiber SERS probes. Properties of the nanocomposites were evaluated using various techniques including UV–vis spectroscopy, μ-Raman spectroscopy, dynamic mechanical analysis, differential scanning calorimetry, thermogravimetric analysis, and transmission electron microscopy.}, number={24}, journal={ANALYTICAL CHEMISTRY}, author={Boyd, Darryl A. and Bezares, Francisco J. and Pacardo, Dennis B. and Ukaegbu, Maraizu and Hosten, Charles and Ligler, Frances S.}, year={2014}, month={Dec}, pages={12315–12320} }