David Christopher Latshaw

Works (4)

Updated: July 16th, 2023 21:18

2017 journal article

Aggregation of amphipathic peptides at an aqueous-organic interface using coarse-grained simulations

MOLECULAR SIMULATION, 43(17), 1448–1458.

By: D. Latshaw n, T. Randolph * & C. Hall n 

author keywords: Amphipathic; monolayer; simulation; interface; aggregation
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Effects of Hydrophobic Macromolecular Crowders on Amyloid beta (16-22) Aggregation

BIOPHYSICAL JOURNAL, 109(1), 124–134.

By: D. Latshaw n & C. Hall n 

MeSH headings : Amyloid beta-Peptides / chemistry; Computer Simulation; Hydrophobic and Hydrophilic Interactions; Models, Chemical; Molecular Dynamics Simulation; Peptide Fragments / chemistry; Protein Multimerization; Protein Structure, Secondary
TL;DR: Strong hydrophobic crowders alter the secondary structure of the Aβ (16-22) monomers, bending them into a shape that is incapable of forming ordered β-sheets or fibrils, qualitatively agree with previous theoretical and experimental work. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Effects of Macromolecular Crowding on Amyloid Beta (16-22) Aggregation Using Coarse-Grained Simulations

JOURNAL OF PHYSICAL CHEMISTRY B, 118(47), 13513–13526.

By: D. Latshaw n, M. Cheon* & C. Hall n 

MeSH headings : Amyloid / chemistry; Amyloid beta-Peptides / chemistry; Kinetics; Molecular Dynamics Simulation; Peptide Fragments / chemistry; Protein Multimerization
TL;DR: To examine the effect of crowding on protein aggregation, discontinuous molecular dynamics simulations combined with an intermediate resolution protein model, PRIME20, were applied to a peptide/crowder system, showing that both crowder volume fraction and crowder diameter have a large impact on fibril and oligomer formation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Gelation and Cross-Linking in Multifunctional Thiol and Multifunctional Acrylate Systems Involving an in Situ Comonomer Catalyst

MACROMOLECULES, 47(2), 821–829.

By: A. Higham n, L. Garber*, D. Latshaw n, C. Hall n , J. Pojman * & S. Khan n 

Sources: Web Of Science, ORCID
Added: August 6, 2018

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