Dereje Demissie Jima
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Works (38)
Updated: August 13th, 2023 21:17
2023 journal article
C/EBP beta deficiency enhances the keratinocyte innate immune response to direct activators of cytosolic pattern recognition receptors
INNATE IMMUNITY, 29(1-2), 14–24.
author keywords: C/EBP beta; cell death; keratinocytes; type I IFN response
MeSH headings : Animals; Mice; Caspase 3 / metabolism; Caspase 8 / metabolism; CCAAT-Enhancer-Binding Protein-beta / genetics; Immunity, Innate; Interferon Type I / metabolism; Keratinocytes; Receptors, Pattern Recognition / genetics; Receptors, Pattern Recognition / metabolism
doi.org (publisher)
Sources: Web Of Science, ORCID
Added: May 30, 2023
2023 journal article
LncRNA Tuna is activated in cadmium-induced placental insufficiency and drives the NRF2-mediated oxidative stress response
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 11.
author keywords: lncRNA; Tuna; placental insufficiency; fetal growth restriction (FGR); Cadmium; Nrf2; oxidative stress
Sources: Web Of Science, ORCID
Added: July 3, 2023
2023 article
Machine learning reveals common transcriptomic signatures across rat brain and placenta following developmental organophosphate ester exposure
Newell, A. J., Jima, D., Reading, B., & Patisaul, H. B. (2023, July 3). TOXICOLOGICAL SCIENCES, Vol. 7.
author keywords: artificial intelligence; toxicogenomics; neurodevelopment; OPFR; OPE; flame retardants; neurotoxicology; hippocampus; cortex; placenta
Sources: Web Of Science, ORCID
Added: July 24, 2023
2023 journal article
Salinity-induced ionoregulatory changes in the gill proteome of the mayfly, Neocloeon triangulifer
ENVIRONMENTAL POLLUTION, 316.
author keywords: Proteomics; Salinity; Mayfly; Gill biology; Ion transport; Osmoregulation
MeSH headings : Animals; Ephemeroptera; Gills / metabolism; Salinity; Proteome / metabolism; Sodium Chloride / metabolism; Proteomics; Calcium Chloride; Water Pollutants, Chemical / metabolism; Aquatic Organisms / metabolism; Sodium-Potassium-Exchanging ATPase / metabolism; Ions / metabolism; Water / metabolism
Sources: Web Of Science, ORCID
Added: January 30, 2023
2022 journal article
A resource for integrated genomic analysis of the human liver
SCIENTIFIC REPORTS, 12(1).
MeSH headings : Bayes Theorem; Genome-Wide Association Study / methods; Genomics; Humans; Liver; Polymorphism, Single Nucleotide; Quantitative Trait Loci
Sources: Web Of Science, ORCID
Added: September 8, 2022
2022 article
Alterations in DNA methylation associate with fatty liver and metabolic abnormalities in a multi-ethnic cohort of pre-teenage children
Moylan, C. A., Mavis, A. M., Jima, D., Maguire, R., Bashir, M., Hyun, J., … Hoyo, C. (2022, February 23). EPIGENETICS.
author keywords: DNA methylation; liver; non-alcoholic fatty liver disease; steatosis; Epigenetics; children
MeSH headings : Adolescent; Humans; Infant, Newborn; Alanine Transaminase / genetics; Alanine Transaminase / metabolism; DNA Methylation; Liver / metabolism; Non-alcoholic Fatty Liver Disease / diagnostic imaging; Non-alcoholic Fatty Liver Disease / genetics
Source: Web Of Science
Added: March 7, 2022
2022 journal article
Genome-wide transcriptome analysis of the orphan crop tef (Eragrostis tef (Zucc.) Trotter) under long-term low calcium stress
SCIENTIFIC REPORTS, 12(1).
MeSH headings : Humans; Eragrostis / genetics; Calcium; Edible Grain / genetics; Crops, Agricultural / genetics; Transcriptome; Gene Expression Profiling
Source: Web Of Science
Added: December 5, 2022
2022 article
Genomic map of candidate human imprint control regions: the imprintome
Jima, D. D., Skaar, D. A., Planchart, A., Motsinger-Reif, A., Cevik, S. E., Park, S. S., … Hoyo, C. (2022, June 25). EPIGENETICS, Vol. 6.
author keywords: Epigenetics; genomic imprinting; foetal origins; whole genome; methylation; imprint control regions
MeSH headings : Adult; Humans; Genomic Imprinting; DNA Methylation; Chromosome Mapping; Alleles; Genomics
Sources: Web Of Science, ORCID
Added: July 11, 2022
2022 journal article
Identification and single-base gene-editing functional validation of a cis-EPO variant as a genetic predictor for EPO-increasing therapies
AMERICAN JOURNAL OF HUMAN GENETICS, 109(9), 1638–1652.
MeSH headings : Anemia / drug therapy; Anemia / genetics; Coronary Artery Disease / genetics; Genome-Wide Association Study; Humans; Mendelian Randomization Analysis; Myocardial Infarction / genetics; Renal Insufficiency, Chronic / genetics
Source: Web Of Science
Added: November 21, 2022
2022 review
Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation
[Review of ]. MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH, 789.
author keywords: DNA methylation; Sex; Children; Cord blood; EWAS
Source: Web Of Science
Added: June 13, 2022
2022 article
TCDD alters essential transcriptional regulators of osteogenic differentiation in multipotent mesenchymal stem cells
Watson, A. L. T. D., Carmona Baez, A., Jima, D., Reif, D., Ding, J., Roberts, R., & Kullman, S. W. (2022, November 12). TOXICOLOGICAL SCIENCES, Vol. 11.
author keywords: mesenchymal stem cell; AhR; cell differentiation
MeSH headings : Humans; Osteogenesis / genetics; Polychlorinated Dibenzodioxins / toxicity; Cell Differentiation; Fibroblast Growth Factors / metabolism; Mesenchymal Stem Cells / metabolism; Cells, Cultured; Osteoblasts
Sources: Web Of Science, ORCID
Added: November 12, 2022
2022 article
The imprinted gene Zac1 regulates steatosis in developmental cadmium-induced nonalcoholic fatty liver disease
Riegl, S. D., Starnes, C., Jima, D. D., Baptissart, M., Diehl, A. M., Belcher, S. M., & Cowley, M. (2022, October 6). TOXICOLOGICAL SCIENCES, Vol. 10.
author keywords: nonalcoholic fatty liver disease; developmental toxicology; epigenetics; cadmium; genomic imprinting; developmental programming
MeSH headings : Mice; Animals; Non-alcoholic Fatty Liver Disease / genetics; Non-alcoholic Fatty Liver Disease / metabolism; Cadmium; Cadmium Chloride / toxicity; PPAR gamma; Liver / metabolism; Fibrosis
Sources: Web Of Science, ORCID
Added: October 29, 2022
2022 article
Zac1 and the Imprinted Gene Network program juvenile NAFLD in response to maternal metabolic syndrome
Baptissart, M., Bradish, C. M., Jones, B. S., Walsh, E., Tehrani, J., Marrero-Colon, V., … Cowley, M. (2022, February 28). HEPATOLOGY, Vol. 2.
MeSH headings : Animals; Cell Cycle Proteins / genetics; Cell Cycle Proteins / metabolism; Disease Models, Animal; Gene Regulatory Networks / genetics; Gene Regulatory Networks / physiology; Genes, Tumor Suppressor / physiology; Metabolic Syndrome / complications; Metabolic Syndrome / genetics; Metabolic Syndrome / metabolism; Mice; Non-alcoholic Fatty Liver Disease / complications; Non-alcoholic Fatty Liver Disease / genetics; Non-alcoholic Fatty Liver Disease / metabolism; Transcription Factors / genetics; Transcription Factors / metabolism; Transforming Growth Factor beta1
Sources: Web Of Science, ORCID
Added: March 28, 2022
2021 journal article
Association between PEG3 DNA methylation and high-grade cervical intraepithelial neoplasia
INFECTIOUS AGENTS AND CANCER, 16(1).
author keywords: Cervical intraepithelial neoplasia; Gene methylation; Imprinted gene; Human papillomavirus
Source: Web Of Science
Added: June 28, 2021
2021 journal article
Transcriptomic, proteomic, and metabolomic analyses identify candidate pathways linking maternal cadmium exposure to altered neurodevelopment and behavior
SCIENTIFIC REPORTS, 11(1).
MeSH headings : Animals; Body Weight / drug effects; Body Weight / genetics; Cadmium / toxicity; Female; Fetal Development / drug effects; Fetal Development / genetics; Humans; Maternal Exposure; Metabolomics / methods; Mice; Mice, Inbred C57BL; Neurodevelopmental Disorders / chemically induced; Neurodevelopmental Disorders / genetics; Placenta / drug effects; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / genetics; Proteomics / methods; Transcriptome / genetics
Sources: Web Of Science, ORCID
Added: August 30, 2021
2020 journal article
A New Liver Expression Quantitative Trait Locus Map From 1,183 Individuals Provides Evidence for Novel Expression Quantitative Trait Loci of Drug Response, Metabolic, and Sex-Biased Phenotypes
CLINICAL PHARMACOLOGY & THERAPEUTICS, 107(6), 1383–1393.
MeSH headings : Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents / adverse effects; Antineoplastic Agents / pharmacology; Child; Child, Preschool; Female; Gene Expression Regulation / genetics; Genetic Variation; Genome-Wide Association Study; Genotype; Humans; Hypolipidemic Agents / pharmacology; Infant; Liver / metabolism; Male; Middle Aged; Phenotype; Proprotein Convertase 9 / genetics; Quantitative Trait Loci / genetics; Receptors, G-Protein-Coupled / genetics; Sex Factors; Young Adult
Sources: Web Of Science, ORCID
Added: February 10, 2020
2020 journal article
Association between DNA methylation and ADHD symptoms from birth to school age: a prospective meta-analysis
TRANSLATIONAL PSYCHIATRY, 10(1).
MeSH headings : Adolescent; Attention Deficit Disorder with Hyperactivity / genetics; Child; Child, Preschool; DNA Methylation; Epigenesis, Genetic; Female; Humans; Infant, Newborn; Pregnancy; Prospective Studies; Schools
Source: Web Of Science
Added: December 21, 2020
2020 journal article
DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies
GENOME MEDICINE, 12(1).
author keywords: Body mass index; Childhood obesity; DNA methylation; Epigenetics
MeSH headings : Adolescent; Body Mass Index; Child; Child, Preschool; CpG Islands; Cross-Sectional Studies; DNA Methylation; Epigenesis, Genetic; Epigenome; Female; Fetal Blood; Humans; Male; Obesity / genetics; Parturition; Pediatric Obesity / genetics; Pregnancy
Source: Web Of Science
Added: December 21, 2020
2020 journal article
Effects of Prenatal Exposure to a Mixture of Organophosphhate Flame Ritardants on Placental Gene Expression and Serotonergic Innervaion in the Fetal Rat Brain
TOXICOLOGICAL SCIENCES, 176(1), 203–223.
author keywords: endocrine disruptors; endocrine toxicology; flame retardants; metabolome; neurotoxicity; developmental; neurotoxicology; neurotransmitter; developmental toxicity; prenatal; reproductive and developmental toxicology; developmental/teratology
MeSH headings : Animals; Brain / drug effects; Female; Fetal Development; Fetus; Flame Retardants / toxicity; Gene Expression; Humans; Male; Organophosphates; Organophosphorus Compounds; Placenta / metabolism; Plasticizers; Polybrominated Biphenyls; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Serotonin / metabolism
Sources: Web Of Science, ORCID
Added: December 14, 2020
2020 article
Expression of UDP Glucuronosyltransferases2B15and2B17is associated with methylation status in prostate cancer cells
EPIGENETICS.
MeSH headings : DNA Methylation; Gene Expression Regulation, Neoplastic; Glucuronosyltransferase / genetics; Glucuronosyltransferase / metabolism; Humans; Male; Minor Histocompatibility Antigens / genetics; Prostatic Neoplasms / genetics
Source: Web Of Science
Added: August 17, 2020
2020 journal article
Transcriptomic and life history responses of the mayfly Neocloeon triangulifer to chronic diel thermal challenge
SCIENTIFIC REPORTS, 10(1).
MeSH headings : Animals; Ephemeroptera / genetics; Ephemeroptera / physiology; Gene Expression Regulation; Heat-Shock Response / genetics; Heat-Shock Response / physiology; Temperature; Transcriptome
Source: Web Of Science
Added: November 30, 2020
2020 journal article
Vitamin D deficiency serves as a precursor to stunted growth and central adiposity in zebrafish
SCIENTIFIC REPORTS, 10(1).
MeSH headings : Adipose Tissue / metabolism; Adiposity / physiology; Animals; Diet; Growth Disorders / metabolism; Hyperplasia / etiology; Hyperplasia / physiopathology; Liver / metabolism; Obesity / metabolism; Obesity, Abdominal / complications; Vitamin D / metabolism; Vitamin D Deficiency / metabolism; Vitamin D Deficiency / physiopathology; Zebrafish / growth & development; Zebrafish / metabolism; Zebrafish Proteins / metabolism
Sources: Web Of Science, ORCID
Added: October 26, 2020
2019 journal article
C/EBP beta suppresses keratinocyte autonomous type 1 IFN response and p53 to increase cell survival and susceptibility to UVB-induced skin cancer
CARCINOGENESIS, 40(9), 1099–1109.
Sources: Web Of Science, ORCID
Added: November 18, 2019
2019 journal article
Epigenome-wide meta-analysis of DNA methylation and childhood asthma
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 143(6), 2062–2074.
author keywords: Epigenetics; methylation; asthma; childhood; newborn; drug development
MeSH headings : Asthma / genetics; Child; CpG Islands / genetics; Cross-Sectional Studies; DNA Methylation; ERG1 Potassium Channel / genetics; Epigenesis, Genetic; Epigenome / genetics; Genome-Wide Association Study; Humans; Infant, Newborn; Interleukin-5 Receptor alpha Subunit / genetics
Source: Web Of Science
Added: June 24, 2019
2019 journal article
Maternal pre-pregnancy obesity, offspring cord blood DNA methylation, and offspring cardiometabolic health in early childhood: an epigenome-wide association study
EPIGENETICS, 14(4), 325–340.
author keywords: DNA methylation; epigenome-wide association study; maternal obesity; offspring body mass index; offspring blood pressure; cardiometabolic health; ALSPAC; NEST
MeSH headings : Adult; Blood Pressure; Cardiovascular Diseases / epidemiology; Cardiovascular Diseases / genetics; Child; Child, Preschool; DNA Methylation; Epigenesis, Genetic; Epigenomics; Female; Genome-Wide Association Study; Humans; Infant, Newborn / blood; Infant, Newborn / growth & development; Male; Membrane Transport Proteins / genetics; Metabolic Syndrome / epidemiology; Metabolic Syndrome / genetics; Obesity / epidemiology; Obesity / genetics
Sources: Web Of Science, ORCID
Added: April 29, 2019
2018 journal article
A common allele in FGF21 associated with sugar intake is associated with body shape, lower total body-fat percentage, and higher blood pressure
Cell Reports, 23(2), 327–336.
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
C/EBPβ deletion in oncogenic Ras skin tumors is a synthetic lethal event
Cell Death & Disease, 9(11).
MeSH headings : 9,10-Dimethyl-1,2-benzanthracene / administration & dosage; Animals; Apoptosis / drug effects; Apoptosis / genetics; CCAAT-Enhancer-Binding Protein-beta / deficiency; CCAAT-Enhancer-Binding Protein-beta / genetics; Cell Differentiation; Cell Transformation, Neoplastic / genetics; Cell Transformation, Neoplastic / metabolism; Cell Transformation, Neoplastic / pathology; Gene Expression Regulation, Neoplastic; Genes, Lethal; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratinocytes / pathology; Mice; Mice, Knockout; Receptors, Death Domain / genetics; Receptors, Death Domain / metabolism; Signal Transduction; Skin / drug effects; Skin / metabolism; Skin / pathology; Skin Neoplasms / chemically induced; Skin Neoplasms / genetics; Skin Neoplasms / metabolism; Skin Neoplasms / pathology; Tetradecanoylphorbol Acetate / administration & dosage; Tetradecanoylphorbol Acetate / analogs & derivatives; Tumor Suppressor Protein p53 / genetics; Tumor Suppressor Protein p53 / metabolism; ras Proteins / genetics; ras Proteins / metabolism
Sources: Web Of Science, Crossref, ORCID
Added: October 29, 2018
2018 journal article
Cohort profile: Pregnancy and childhood epigenetics (PACE) consortium
International Journal of Epidemiology, 47(1), 22-.
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
EDC IMPACT: Molecular effects of developmental FM 550 exposure in Wistar rat placenta and fetal forebrain
ENDOCRINE CONNECTIONS, 7(2), 305–324.
author keywords: endocrine disruptors; flame retardants; behavior; serotonin; sexually dimorphic; EDC; brain
Sources: Web Of Science, ORCID
Added: August 6, 2018
2018 journal article
Effects of cadmium exposure on DNA methylation at imprinting control regions and genome-wide in mothers and newborn children
Environmental Health Perspectives, 126(3).
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
HT-eQTL: integrative expression quantitative trait loci analysis in a large number of human tissues
BMC Bioinformatics, 19.
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
Prenatal bisphenol A (BPA) exposure alters the transcriptome of the neonate rat amygdala in a sex-specific manner: a CLARITY-BPA consortium study
NEUROTOXICOLOGY, 65, 207–220.
author keywords: Endocrine disruptor; EDC; Brain; Oxytocin; Sex difference; Estrogen; Androgen
MeSH headings : Amygdala / drug effects; Amygdala / metabolism; Animals; Animals, Newborn; Benzhydryl Compounds / toxicity; Dose-Response Relationship, Drug; Ethinyl Estradiol / pharmacology; Female; Male; Phenols / toxicity; Pregnancy; Prenatal Exposure Delayed Effects / metabolism; Rats; Sex Characteristics; Signal Transduction / drug effects; Transcriptome / drug effects
Sources: Web Of Science, ORCID
Added: August 6, 2018
2018 journal article
The Good, the Bad, and the Lethal: Gene Expression and Metabolomics Reveal Physiological Mechanisms Underlying Chronic Thermal Effects in Mayfly Larvae (Neocloeon triangulifer)
FRONTIERS IN ECOLOGY AND EVOLUTION, 6.
author keywords: aquatic insects; mayfly; thermal limits; metabolomics; temperature
Source: Web Of Science
Added: December 17, 2018
2017 journal article
A Pipeline for high-throughput concentration response modeling of gene expression for toxicogenomics
Frontiers in Genetics, 8.
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
Disruption of Trim9 function abrogates macrophage motility in vivo
Journal of Leukocyte Biology, 102(6), 1371–1380.
author keywords: chemotaxis; zebrafish; leukocyte; ubiquitin
MeSH headings : Animals; Cell Movement / genetics; Cell Shape; Chemotaxis; Humans; Macrophages / cytology; Macrophages / metabolism; Nerve Tissue Proteins / genetics; Nerve Tissue Proteins / metabolism; RNA, Messenger / genetics; RNA, Messenger / metabolism; Tripartite Motif Proteins / genetics; Tripartite Motif Proteins / metabolism; U937 Cells; Ubiquitin-Protein Ligases / genetics; Ubiquitin-Protein Ligases / metabolism; Zebrafish / genetics; Zebrafish / immunology; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2017 journal article
Nuclear Localized LSR: A Novel Regulator of Breast Cancer Behavior and Tumorigenesis
MOLECULAR CANCER RESEARCH, 15(2), 165–178.
MeSH headings : Animals; Breast Neoplasms / genetics; Breast Neoplasms / metabolism; Breast Neoplasms / pathology; Carcinogenesis / genetics; Carcinogenesis / metabolism; Carcinogenesis / pathology; Cell Transformation, Neoplastic / genetics; Cell Transformation, Neoplastic / metabolism; Cell Transformation, Neoplastic / pathology; Female; Heterografts; Humans; Mice; Receptors, LDL / biosynthesis; Receptors, LDL / genetics; Receptors, LDL / metabolism
Source: Web Of Science
Added: August 6, 2018
2017 journal article
The Arsenic Resistance-Associated Listeria Genomic Island LGI2 Exhibits Sequence and Integration Site Diversity and a Propensity for Three Listeria monocytogenes Clones with Enhanced Virulence
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 83(21).
author keywords: Listeria monocytogenes; arsenic resistance; genomic island; heavy metal resistance; hypervirulent clones
MeSH headings : Arsenic / metabolism; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Genetic Variation; Genomic Islands; Humans; Listeria monocytogenes / genetics; Listeria monocytogenes / metabolism; Listeria monocytogenes / pathogenicity; Listeriosis / microbiology; Virulence
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Enhanced transcription of complement and coagulation genes in the absence of adaptive immunity
Molecular Immunology, 46(7), 1505–1516.
author keywords: Zebrafish; Mouse; rag1; Innate immunity; SCID
MeSH headings : Adaptation, Physiological / genetics; Adaptation, Physiological / immunology; Animals; Animals, Genetically Modified; Blood Coagulation Factors / genetics; Blood Coagulation Factors / metabolism; Complement C4 / genetics; Complement C4 / metabolism; Complement System Proteins / genetics; Complement System Proteins / metabolism; Female; Gene Expression Profiling; Genes, RAG-1 / physiology; Immunity / genetics; Immunity / physiology; Intestinal Mucosa / metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Transcription, Genetic; Up-Regulation; Zebrafish
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
