2018 journal article

Population pharmacokinetics of ceftazidime after a single intramuscular injection in wild turtles

Journal of Veterinary Pharmacology and Therapeutics, 41(4), 495–501.

By: A. Cerreta n, G. Lewbart n, D. Dise n & M. Papich n

author keywords: ceftazidime; nonlinear mixed-effects modeling; pharmacokinetics; turtles
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Ceftazidime / administration & dosage; Ceftazidime / blood; Ceftazidime / pharmacokinetics; Chromatography, High Pressure Liquid / veterinary; Injections, Intramuscular / veterinary; Turtles / blood; Turtles / metabolism
TL;DR: This investigation used a population pharmacokinetic approach to study ceftazidime in wild turtles presented for rehabilitation, and concluded that this long T½ will allow for a dose of 20 mg/kg injected IM to maintain concentrations above the MIC of most wild-type bacteria for 5 days. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018

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