Deniz Durmusoglu

Works (8)

Updated: September 20th, 2024 05:00

2024 journal article

A cell-free transcription-translation pipeline for recreating methylation patterns boosts DNA transformation in bacteria

MOLECULAR CELL, 84(14).

By: J. Vento n, D. Durmusoglu n, T. Li n, C. Patinios *, S. Sullivan  n, F. Ttofali n, J. Schaik n, Y. Yu * ...

Sources: Web Of Science, NC State University Libraries
Added: September 16, 2024

2023 journal article

Design of 8-mer peptides that block <i>Clostridioides difficile</i> toxin A in intestinal cells

COMMUNICATIONS BIOLOGY, 6(1).

By: S. Sarma n, C. Catella n, E. San Pedro*, X. Xiao n, D. Durmusoglu n, S. Menegatti n , N. Crook n , S. Magness*, C. Hall n 

TL;DR: An approach that combines a Pep tide B inding D esign (PepBD) algorithm, molecular-level simulations, a rapid screening assay, and surface plasmon resonance (SPR) measurements to develop peptide inhibitors that block Toxin A in colon epithelial cells is described. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 27, 2023

2023 journal article

Improving therapeutic protein secretion in the probiotic yeast Saccharomyces boulardii using a multifactorial engineering approach

MICROBIAL CELL FACTORIES, 22(1).

By: D. Durmusoglu n, I. Al'Abri n, Z. Li n, T. Islam Williams  n, L. Collins n , J. Martinez *, N. Crook n 

Contributors: D. Durmusoglu n, I. Al’Abri  n, Z. Li n, T. Islam Williams  n, L. Collins n , J. Martínez *, N. Crook n 

MeSH headings : Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Saccharomyces boulardii / genetics; Saccharomyces boulardii / metabolism; Saccharomyces / genetics; Saccharomyces / metabolism; Probiotics / metabolism; Endopeptidases / metabolism
TL;DR: A quadruple protease-deficient Sb strain is constructed that produces 5045 mg/L secretory NPA, an improvement of tenfold over wild-type Sb and highlights the ability of proteomics to highlight under-explored mediators of this process. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 19, 2023

2022 journal article

Engineered cell differentiation and sexual reproduction in probiotic and mating yeasts

NATURE COMMUNICATIONS, 13(1).

By: E. Jensen *, M. Deichmann *, X. Ma *, R. Vilandt*, G. Schiesaro *, M. Rojek*, B. Lengger *, L. Eliasson* ...

MeSH headings : Saccharomyces cerevisiae / metabolism; Reproduction / genetics; Receptors, G-Protein-Coupled / metabolism; Pheromones / metabolism; Receptors, Cell Surface / metabolism; Cell Differentiation; Cell Communication; Probiotics; Ligands
TL;DR: This work reports transcriptome profiles following mating pathway activation in native and hGPCR-signaling yeast, and uses a model-guided approach to correlate gene expression to morphological changes, and devise a ligand-free screening strategy for hGpcR compatibility with the yeast mating pathway and enable hG PCR-Signaling in the probiotic yeast Saccharomyces boulardii. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: October 31, 2022

2021 journal article

Design and in situ biosynthesis of precision therapies against gastrointestinal pathogens

CURRENT OPINION IN PHYSIOLOGY, 23.

By: D. Durmusoglu n, C. Catella n, E. Purnell n, S. Menegatti n  & N. Crook n 

TL;DR: Recent progress in understanding of small molecules that inhibit specific virulence mechanisms point to an emerging integrative approach to treatment of gastrointestinal diseases, comprising microbiologists, peptide chemists, and synthetic biologists. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: October 26, 2021

2021 review

Discovery and delivery strategies for engineered live biotherapeutic products

[Review of ]. TRENDS IN BIOTECHNOLOGY, 40(3), 354–369.

By: M. Heavey *, D. Durmusoglu n, N. Crook n  & A. Anselmo *

MeSH headings : Administration, Oral; Genetic Engineering; Probiotics / therapeutic use
TL;DR: This review describes recent approaches (often demonstrated using traditional probiotic microorganisms) to discover LBP chassis and genetic parts utilizing omics-based methods and highlights LBP delivery strategies, with a focus on addressing physiological challenges that LBPs encounter after oral administration. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: March 7, 2022

2021 journal article

In Situ Biomanufacturing of Small Molecules in the Mammalian Gut by Probiotic Saccharomyces boulardii

ACS SYNTHETIC BIOLOGY, 10(5), 1039–1052.

By: D. Durmusoglu n, I. Al'Abri n, S. Collins n, J. Cheng n, A. Eroglu n , C. Beisel n, N. Crook n 

author keywords: Saccharomyces boulardii; probiotic engineering; metabolic engineering; colonization profile; in situ production; beta-carotene
MeSH headings : Animals; Antineoplastic Agents / metabolism; CRISPR-Cas Systems; Feces / chemistry; Female; Gastrointestinal Microbiome; Gastrointestinal Tract / metabolism; Gastrointestinal Tract / microbiology; Gene Editing / methods; Gene Expression; Indoles / metabolism; Male; Metabolic Engineering / methods; Mice; Mice, Inbred C57BL; Microorganisms, Genetically-Modified; Multigene Family; Plasmids / genetics; Probiotics / metabolism; Promoter Regions, Genetic; Provitamins / biosynthesis; Saccharomyces boulardii / genetics; Saccharomyces boulardii / metabolism; Saccharomyces cerevisiae / genetics; beta Carotene / biosynthesis
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: May 6, 2021

2021 article

What E. coli knows about your 1-year-old infant: Antibiotic use, lifestyle, birth mode, and siblings

Al'Abri, I. S., Durmusoglu, D., & Crook, N. (2021, June 9). CELL HOST & MICROBE, Vol. 29, pp. 854–855.

By: I. Al'Abri n, D. Durmusoglu n & N. Crook n 

MeSH headings : Anti-Bacterial Agents / pharmacology; Asthma; Child; Environmental Exposure; Escherichia coli; Gastrointestinal Microbiome; Humans; Infant; Life Style; Siblings
TL;DR: The causes, spread, and dynamics of ARGs and their relationship with asthma-associated microbiota in Danish children are studied and the relationship between asthma and the gut microbiota is studied. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: June 28, 2021

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