Deniz Durmusoglu

Works (10)

Updated: March 5th, 2026 14:36

2026 article

Transcriptomic responses of Saccharomyces boulardii to the germ-free mouse gut

Wang, G., Durmusoglu, D., & Crook, N. (2026, February 18). BMC Genomics, Vol. 2.

By: G. Wang n, D. Durmusoglu n & N. Crook n 

topics (OpenAlex): Fungal and yeast genetics research; Bacterial Genetics and Biotechnology; Probiotics and Fermented Foods; Arsenic contamination and mitigation; Selenium in Biological Systems; Aluminum toxicity and tolerance in plants and animals
Sources: NC State University Libraries, NC State University Libraries
Added: March 4, 2026

2025 article

Development of Peptide Glucosyltransferase Inhibitors With Comprehensive Coverage Across Clostridioides difficile Toxin B Sub‐Types

Catella, C. M., Sarma, S., Hinesley, C. M., Febo, C. E., Breau, K. A., Durmusoglu, D., … Crook, N. (2025, November 14). Biotechnology and Bioengineering.

By: C. Catella n, S. Sarma n, C. Hinesley *, C. Febo n, K. Breau *, D. Durmusoglu n, E. Purnell n, S. Magness* ...

topics (OpenAlex): Clostridium difficile and Clostridium perfringens research; Helicobacter pylori-related gastroenterology studies; Yersinia bacterium, plague, ectoparasites research
Sources: NC State University Libraries, NC State University Libraries
Added: November 16, 2025

2024 article

A cell-free transcription-translation pipeline for recreating methylation patterns boosts DNA transformation in bacteria

Vento, J. M., Durmusoglu, D., Li, T., Patinios, C., Sullivan, S., Ttofali, F., … Beisel, C. L. (2024, June 26). Molecular Cell, Vol. 84.

By: J. Vento n, D. Durmusoglu n, T. Li n, C. Patinios *, S. Sullivan  n, F. Ttofali n, J. Schaik n, Y. Yu * ...

MeSH headings : Transcription, Genetic; Cell-Free System; DNA Methylation; Protein Biosynthesis; Escherichia coli / genetics; Escherichia coli / metabolism; Transformation, Bacterial; DNA, Bacterial / genetics; DNA, Bacterial / metabolism; Plasmids / genetics; Plasmids / metabolism; DNA Modification Methylases / metabolism; DNA Modification Methylases / genetics; Bacterial Proteins / genetics; Bacterial Proteins / metabolism
topics (OpenAlex): Bacterial Genetics and Biotechnology; Bacteriophages and microbial interactions; CRISPR and Genetic Engineering
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Sources: Web Of Science, NC State University Libraries
Added: September 16, 2024

2023 article

Design of 8-mer peptides that block Clostridioides difficile toxin A in intestinal cells

Sarma, S., Catella, C. M., Pedro, E. T. S., Xiao, X., Durmusoglu, D., Menegatti, S., … Hall, C. K. (2023, August 26). Communications Biology, Vol. 6.

By: S. Sarma n, C. Catella n, E. Pedro*, X. Xiao n, D. Durmusoglu n, S. Menegatti n , N. Crook n , S. Magness*, C. Hall n 

topics (OpenAlex): Clostridium difficile and Clostridium perfringens research; Microscopic Colitis; Toxin Mechanisms and Immunotoxins
TL;DR: An approach that combines a Pep tide B inding D esign (PepBD) algorithm, molecular-level simulations, a rapid screening assay, and surface plasmon resonance (SPR) measurements to develop peptide inhibitors that block Toxin A in colon epithelial cells is described. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 27, 2023

2023 article

Improving therapeutic protein secretion in the probiotic yeast Saccharomyces boulardii using a multifactorial engineering approach

Durmusoglu, D., Al’Abri, I., Li, Z., Williams, T. I., Collins, L. B., Martínez, J. L., & Crook, N. (2023, June 7). Microbial Cell Factories, Vol. 22.

By: D. Durmusoglu n, I. Al’Abri n, Z. Li n, T. Williams n , L. Collins n , J. Martínez *, N. Crook n 

Contributors: D. Durmusoglu n, I. Al’Abri n, Z. Li n, T. Williams n , L. Collins n , J. Martínez *, N. Crook n 

MeSH headings : Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Saccharomyces boulardii / genetics; Saccharomyces boulardii / metabolism; Saccharomyces / genetics; Saccharomyces / metabolism; Probiotics / metabolism; Endopeptidases / metabolism
topics (OpenAlex): Fungal and yeast genetics research; Bacterial Genetics and Biotechnology; Microbial Inactivation Methods; Transgenic Plants and Applications; Microbial Metabolic Engineering and Bioproduction
TL;DR: A quadruple protease-deficient Sb strain is constructed that produces 5045 mg/L secretory NPA, an improvement of tenfold over wild-type Sb and highlights the ability of proteomics to highlight under-explored mediators of this process. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 19, 2023

2022 article

Engineered cell differentiation and sexual reproduction in probiotic and mating yeasts

Jensen, E. D., Deichmann, M., Ma, X., Vilandt, R. U., Schiesaro, G., Rojek, M. B., … Jensen, M. K. (2022, October 19). Nature Communications, Vol. 10.

By: E. Jensen *, M. Deichmann *, X. Ma *, R. Vilandt*, G. Schiesaro *, M. Rojek*, B. Lengger *, L. Eliasson* ...

MeSH headings : Saccharomyces cerevisiae / metabolism; Reproduction / genetics; Receptors, G-Protein-Coupled / metabolism; Pheromones / metabolism; Receptors, Cell Surface / metabolism; Cell Differentiation; Cell Communication; Probiotics; Ligands
topics (OpenAlex): Fungal and yeast genetics research; Plant Reproductive Biology; Yeasts and Rust Fungi Studies
TL;DR: This work reports transcriptome profiles following mating pathway activation in native and hGPCR-signaling yeast, and uses a model-guided approach to correlate gene expression to morphological changes, and devise a ligand-free screening strategy for hGpcR compatibility with the yeast mating pathway and enable hG PCR-Signaling in the probiotic yeast Saccharomyces boulardii. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: October 31, 2022

2021 article

In Situ Biomanufacturing of Small Molecules in the Mammalian Gut by Probiotic Saccharomyces boulardii

Durmusoglu, D., Al’Abri, I. S., Collins, S. P., Cheng, J., Eroglu, A., Beisel, C. L., & Crook, N. (2021, April 12). ACS Synthetic Biology, Vol. 10, pp. 1039–1052.

By: D. Durmusoglu n, I. Al’Abri n, S. Collins n, J. Cheng n, A. Eroglu n , C. Beisel n, N. Crook n 

author keywords: Saccharomyces boulardii; probiotic engineering; metabolic engineering; colonization profile; in situ production; beta-carotene
MeSH headings : Animals; Antineoplastic Agents / metabolism; CRISPR-Cas Systems; Feces / chemistry; Female; Gastrointestinal Microbiome; Gastrointestinal Tract / metabolism; Gastrointestinal Tract / microbiology; Gene Editing / methods; Gene Expression; Indoles / metabolism; Male; Metabolic Engineering / methods; Mice; Mice, Inbred C57BL; Microorganisms, Genetically-Modified; Multigene Family; Plasmids / genetics; Probiotics / metabolism; Promoter Regions, Genetic; Provitamins / biosynthesis; Saccharomyces boulardii / genetics; Saccharomyces boulardii / metabolism; Saccharomyces cerevisiae / genetics; beta Carotene / biosynthesis
topics (OpenAlex): Microbial Metabolism and Applications; Probiotics and Fermented Foods; CRISPR and Genetic Engineering
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: May 6, 2021

2021 article

Design and in situ biosynthesis of precision therapies against gastrointestinal pathogens

Durmusoglu, D., Catella, C. M., Purnell, E. F., Menegatti, S., & Crook, N. C. (2021, July 1). Current Opinion in Physiology, Vol. 23.

By: D. Durmusoglu n, C. Catella n, E. Purnell n, S. Menegatti n  & N. Crook n 

topics (OpenAlex): Antimicrobial Peptides and Activities; Probiotics and Fermented Foods; Antifungal resistance and susceptibility
TL;DR: Recent progress in understanding of small molecules that inhibit specific virulence mechanisms point to an emerging integrative approach to treatment of gastrointestinal diseases, comprising microbiologists, peptide chemists, and synthetic biologists. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: October 26, 2021

2021 article

Discovery and delivery strategies for engineered live biotherapeutic products

Heavey, M. K., Durmusoglu, D., Crook, N., & Anselmo, A. C. (2021, September 1). Trends in Biotechnology.

By: M. Heavey *, D. Durmusoglu n, N. Crook n  & A. Anselmo *

MeSH headings : Administration, Oral; Genetic Engineering; Probiotics / therapeutic use
topics (OpenAlex): Transgenic Plants and Applications; Gut microbiota and health; Probiotics and Fermented Foods
TL;DR: This review describes recent approaches (often demonstrated using traditional probiotic microorganisms) to discover LBP chassis and genetic parts utilizing omics-based methods and highlights LBP delivery strategies, with a focus on addressing physiological challenges that LBPs encounter after oral administration. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: March 7, 2022

2021 article

What E. coli knows about your 1-year-old infant: Antibiotic use, lifestyle, birth mode, and siblings

Al’Abri, I. S., Durmusoglu, D., & Crook, N. (2021, June 1). Cell Host & Microbe, Vol. 6.

By: I. Al’Abri n, D. Durmusoglu n & N. Crook n 

MeSH headings : Anti-Bacterial Agents / pharmacology; Asthma; Child; Environmental Exposure; Escherichia coli; Gastrointestinal Microbiome; Humans; Infant; Life Style; Siblings
topics (OpenAlex): Pharmaceutical studies and practices; Neuroendocrine regulation and behavior; Antibiotic Use and Resistance
TL;DR: The causes, spread, and dynamics of ARGs and their relationship with asthma-associated microbiota in Danish children are studied and the relationship between asthma and the gut microbiota is studied. (via Semantic Scholar)
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11. Sustainable Cities and Communities (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 28, 2021

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