Derek Evan Adrian

Works (5)

Updated: July 5th, 2023 15:32

2021 article

Clinical safety of robenacoxib in cats with chronic musculoskeletal disease

King, J. N., Seewald, W., Forster, S., Friton, G., Adrian, D. E., & Lascelles, B. D. X. (2021, July 2). Journal of Veterinary Internal Medicine, Vol. 7.

By: J. King *, W. Seewald*, S. Forster *, G. Friton *, D. Adrian n  & B. Lascelles n 

author keywords: adverse event; coxib; harm; NSAID
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / adverse effects; Cat Diseases / drug therapy; Cats; Diphenylamine / adverse effects; Diphenylamine / analogs & derivatives; Musculoskeletal Diseases / drug therapy; Musculoskeletal Diseases / veterinary; Phenylacetates; Prospective Studies
topics (OpenAlex): Veterinary Oncology Research; Veterinary Orthopedics and Neurology; Shoulder Injury and Treatment
TL;DR: Robenacoxib was not associated with increased risk of AEs compared to placebo when administered for 4 to 12 weeks to cats with CMSD and generalizability of the results to general practice is limited by the fact that cases with severe and uncontrolled concomitant diseases were not included. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: July 12, 2021

2021 journal article

Robenacoxib shows efficacy for the treatment of chronic degenerative joint disease-associated pain in cats: a randomized and blinded pilot clinical trial

Scientific Reports Volume, 11, 7721.

By: D. Adrian n , J. King, R. Parrish*, S. King*, S. Budsberg*, M. Gruen n , B. Lascelles* 

MeSH headings : Animals; Cat Diseases / drug therapy; Cats; Diphenylamine / analogs & derivatives; Diphenylamine / therapeutic use; Female; Joint Diseases / complications; Joint Diseases / veterinary; Male; Osteoarthritis / complications; Osteoarthritis / veterinary; Pain / complications; Pain / veterinary; Pain Management / veterinary; Phenylacetates / therapeutic use; Pilot Projects; Placebos
topics (OpenAlex): Veterinary Orthopedics and Neurology; Inflammatory mediators and NSAID effects; Osteoarthritis Treatment and Mechanisms
TL;DR: Results identified suitable endpoints for confirmatory studies, while also indicating efficacy of robenacoxib in cats with DJD-pain, and decreased owner-assessed disability. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: April 18, 2021

2018 journal article

Prescribing Practices of Veterinarians in the Treatment of Chronic Musculoskeletal Pain in Cats

J Feline Med Surg, 7(6), 495–506.

By: D. Adrian n , M. Rishniw, M. Scherk & B. Lascelles n 

author keywords: Musculoskeletal pain; analgesics; surveys; questionnaires
MeSH headings : Animals; Cat Diseases / drug therapy; Cats; Cross-Sectional Studies; Musculoskeletal Pain / drug therapy; Musculoskeletal Pain / veterinary; Practice Patterns, Physicians' / statistics & numerical data; Surveys and Questionnaires; Veterinarians / statistics & numerical data
topics (OpenAlex): Veterinary Orthopedics and Neurology; Veterinary Pharmacology and Anesthesia; Veterinary Equine Medical Research
TL;DR: The results show a contrast between therapies prescribed by practitioners and what is supported by evidenced-based literature, and future research evaluating the safety and efficacy of gabapentin should be prioritised. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: January 25, 2019

2018 article

The pharmacokinetics of gabapentin in cats

Adrian, D., Papich, M. G., Baynes, R., Stafford, E., & Lascelles, B. D. X. (2018, October 11). Journal of Veterinary Internal Medicine, Vol. 32, pp. 1996–2002.

By: D. Adrian n , M. Papich n , R. Baynes n , E. Stafford n & B. Lascelles n 

author keywords: compounded; feline; pain; transdermal
MeSH headings : Analgesics / administration & dosage; Analgesics / blood; Analgesics / pharmacokinetics; Animals; Cats / metabolism; Female; Gabapentin / administration & dosage; Gabapentin / blood; Gabapentin / pharmacokinetics; Half-Life; Injections, Intravenous / veterinary; Male
topics (OpenAlex): Pain Mechanisms and Treatments; Veterinary Pharmacology and Anesthesia; Veterinary Equine Medical Research
TL;DR: Repeated oral dosing of gabapentin did not alter the drug's pharmacokinetics, making dose adjustments unnecessary with long‐term treatment, and the transdermal route is an inappropriate choice for drug administration. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 31, 2018

2017 journal article

Chronic maladaptive pain in cats: A review of current and future drug treatment options

The Veterinary Journal, 230, 52–61.

By: D. Adrian n , M. Papich n , R. Baynes n, J. Murrell* & B. Lascelles n 

author keywords: Maladaptive pain; Cats; Analgesia; Central plasticity; Chronic pain
MeSH headings : Analgesics / therapeutic use; Animals; Cat Diseases / diagnosis; Cat Diseases / drug therapy; Cats; Chronic Pain / diagnosis; Chronic Pain / drug therapy; Chronic Pain / veterinary; Forecasting; Pain Management / trends; Pain Management / veterinary; Pain Measurement / veterinary
topics (OpenAlex): Pain Mechanisms and Treatments; Veterinary Pharmacology and Anesthesia; Pain Management and Opioid Use
TL;DR: The current understanding of chronic or maladaptive pain, techniques for the detection and measurement of the condition and the associated central nervous changes, as well as an overview of the data evaluating potential therapeutics in cats are detailed. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: February 11, 2019

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