Works (21)
Updated: September 10th, 2024 05:03
2024 article
Classic Lesions of the Biliary Tree
Cullen, J. M., Malarkey, D., & Foster, J. R. (2024, August 27). TOXICOLOGIC PATHOLOGY.
author keywords: cholangiofibrosis; ductular reaction; canalicular cholestasis; biliary hyperplasia
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Web Of Science
Added: September 9, 2024
2022 article
Inter-pathologist agreement on diagnosis, classification and grading of canine glioma
Krane, G. A., Shockley, K. R., Malarkey, D. E., Miller, A. D., Miller, C. R., Tokarz, D. A., … Mariani, C. L. (2022, July 30). VETERINARY AND COMPARATIVE ONCOLOGY, Vol. 7.
author keywords: brain; cancer; dog; histopathology; immunohistochemistry
MeSH headings : Humans; Animals; Dogs; Oligodendroglioma / diagnosis; Oligodendroglioma / veterinary; Oligodendroglioma / pathology; Pathologists; Dog Diseases / diagnosis; Dog Diseases / pathology; Glioma / diagnosis; Glioma / veterinary; Glioma / pathology; Astrocytoma / veterinary; Brain Neoplasms / diagnosis; Brain Neoplasms / veterinary; Brain Neoplasms / pathology
TL;DR:
Inter‐pathologist agreement utilising CBTC guidelines for canine glioma was moderate overall but varied from fair to almost perfect between pairs of pathologists, similar for oligodendrogliomas and astrocytomas but lower for undefined gliomas.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 8, 2022
2021 journal article
A deleterious mutation in the ALMS1 gene in a naturally occurring model of hypertrophic cardiomyopathy in the Sphynx cat
ORPHANET JOURNAL OF RARE DISEASES, 16(1).
author keywords: Hypertrophic cardiomyopathy; ALMS1; Feline; Mitogenic; Sphynx
MeSH headings : Animals; Cardiomyopathy, Hypertrophic / genetics; Cats / genetics; Cell Cycle Proteins / genetics; Exons; Mice; Mutation / genetics
TL;DR:
This study demonstrates a novel form of cardiomyopathy associated with ALMS1 in the cat, and suggests that variants in genes involved with cardiac development and cell regulation, like the AL MS1 gene, may deserve further consideration for association with familial hypertrophic cardiopathy.
(via Semantic Scholar)
open access via ojrd.biomedcentral.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 12, 2021
2021 article
Immunohistochemical evaluation of immune cell infiltration in canine gliomas
Krane, G. A., Carly A. O'Dea, Malarkey, D. E., Miller, A. D., Miller, C. R., Tokarz, D. A., … Mariani, C. L. (2021, July 1). VETERINARY PATHOLOGY, Vol. 7.
author keywords: astrocytoma; brain; dogs; cancer; immunohistochemistry; immunology; lymphocytes; macrophages; oligodendroglioma
MeSH headings : Animals; Antigens, CD20; Dog Diseases; Dogs; Glioma / veterinary; Immunohistochemistry; Lymphocytes, Tumor-Infiltrating; T-Lymphocytes, Regulatory
TL;DR:
The distribution of immune cells infiltrating spontaneous intracranial canine gliomas was determined and there was a significant increase in tumor area fraction of CD163 compared to Mac387, and this ratio was greater in high- grade tumors than in low-grade tumors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 2, 2021
2009 journal article
Expression of epidermal growth factor receptor and vascular endothelial growth factor in malignant canine epithelial nasal tumours
VETERINARY AND COMPARATIVE ONCOLOGY, 7(2), 106–114.
author keywords: canine; EGFR; nasal tumour; radiosensitivity; VEGF
MeSH headings : Animals; Dog Diseases / metabolism; Dog Diseases / pathology; Dog Diseases / radiotherapy; Dogs; ErbB Receptors / metabolism; Gene Expression Regulation, Neoplastic; Immunohistochemistry / veterinary; Neoplasms, Glandular and Epithelial / metabolism; Neoplasms, Glandular and Epithelial / pathology; Neoplasms, Glandular and Epithelial / radiotherapy; Neoplasms, Glandular and Epithelial / veterinary; Nose Neoplasms / radiotherapy; Nose Neoplasms / veterinary; Treatment Outcome; Vascular Endothelial Growth Factor A / metabolism
TL;DR:
Findings indicate that EGFR and VEGF proteins were present in some malignant epithelial nasal tumours in the dogs, and therefore, it may be beneficial to treat canine patients with tumours that overexpress EG FR and V EGF with specific inhibitors in conjunction with radiation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Epibulbar melanoma in a foal
Veterinary Ophthalmology, 11, 44–50.
author keywords: congenital; epibulbar; equine; melanoma; neoplasia
MeSH headings : Animals; Animals, Newborn; Choroid Neoplasms / pathology; Choroid Neoplasms / surgery; Choroid Neoplasms / veterinary; Eye Enucleation / methods; Eye Enucleation / veterinary; Eye Neoplasms / pathology; Eye Neoplasms / surgery; Eye Neoplasms / veterinary; Horse Diseases / pathology; Horse Diseases / surgery; Horses; Limbus Corneae; Macrophages / pathology; Male; Melanoma / pathology; Melanoma / surgery; Melanoma / veterinary; Pigment Epithelium of Eye / pathology; Treatment Outcome
TL;DR:
Based on the sudden onset and rapid growth as well as the histological evidence of invasion, well-differentiated features, heavy pigmentation, and no apparent mitoses, this neoplasm was considered to be a low-grade malignant melanoma.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2004 article
Expression of cyclooxygenase-2 in canine epithelial nasal tumors
VETERINARY RADIOLOGY & ULTRASOUND, Vol. 45, pp. 255–260.
author keywords: canine; cyclooxygenase-2; nasal tumors; radiation therapy
MeSH headings : Adenocarcinoma / enzymology; Adenocarcinoma / veterinary; Animals; Carcinoma, Squamous Cell / enzymology; Carcinoma, Squamous Cell / veterinary; Case-Control Studies; Combined Modality Therapy; Cyclooxygenase 2; Dog Diseases / drug therapy; Dog Diseases / enzymology; Dog Diseases / radiotherapy; Dogs; Gene Expression Regulation, Neoplastic; Immunohistochemistry; Isoenzymes / metabolism; Nose Neoplasms / enzymology; Nose Neoplasms / veterinary; Prostaglandin-Endoperoxide Synthases / metabolism; Records / veterinary; Retrospective Studies
TL;DR:
A combination therapy of irradiation and a selective COX-2 inhibitor appears worthy of clinical investigation in the treatment of canine epithelial nasal tumors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Identification of spontaneous feline idiopathic pulmonary fibrosis - Morphology and ultrastructural evidence for a type II pneumocyte defect
CHEST, 125(6), 2278–2288.
author keywords: animal model; cats; fibrosis; idiopathic pulmonary fibrosis; lung; type II pneumocytes
MeSH headings : Animals; Apoptosis; Cats; Culture Techniques; Disease Models, Animal; Female; Immunohistochemistry; Male; Microscopy, Electron; Probability; Pulmonary Alveoli / cytology; Pulmonary Alveoli / ultrastructure; Pulmonary Fibrosis / pathology; Reference Values; Sensitivity and Specificity
TL;DR:
Sp spontaneous IPF in domestic cats is identified and it is hypothesized that this newly identified disease shares the pathology of human IPF; further, this work provides data suggesting that the disease is related to a defect in type II pneumocyte biology.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2003 journal article
Radiographic features of aortic bulb/valve mineralization in 20 dogs
VETERINARY RADIOLOGY & ULTRASOUND, 44(1), 20–27.
author keywords: canine; aortic bulb mineralization; radiography
MeSH headings : Animals; Aortic Valve / diagnostic imaging; Aortic Valve / pathology; Calcification, Physiologic; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Dogs; Female; Male; Radiography
TL;DR:
Based on the histologic findings in one dog, the mineralization seen in the aortic root is similar to a form of dystrophic mineralization called Monckeberg's calcific arteriosclerosis in humans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2002 article
Heterobilharzia americana infection in a dog
Flowers, JR, Hammerberg, B., Wood, S. L., Malarkey, D. E., Dam, G. J., Levy, M. G., & McLawhorn, L. D. (2002, January 15). JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 220, pp. 193–196.
MeSH headings : Animals; Anthelmintics / therapeutic use; Antigens, Helminth / blood; Antigens, Helminth / immunology; Dog Diseases / diagnosis; Dog Diseases / drug therapy; Dog Diseases / parasitology; Dogs; Enzyme-Linked Immunosorbent Assay / veterinary; Feces / parasitology; Male; Parasite Egg Count / veterinary; Praziquantel / therapeutic use; Schistosomatidae / isolation & purification; Trematode Infections / diagnosis; Trematode Infections / drug therapy; Trematode Infections / parasitology; Trematode Infections / veterinary
TL;DR:
It is suggested that heterobilharziasis is underdiagnosed in dogs that have contact with water frequented by raccoons and inappropriate diagnostic procedures can foil accurate detection of this parasitic disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
Lack of teratogenicity of microcystin-LR in the mouse and toad
JOURNAL OF APPLIED TOXICOLOGY, 22(1), 13–17.
author keywords: microcystin; developmental toxicology; mouse; frog; embryo
MeSH headings : Animals; Bufo arenarum / abnormalities; Cyanobacteria / pathogenicity; Embryo, Mammalian / abnormalities; Embryo, Mammalian / drug effects; Embryo, Nonmammalian / abnormalities; Embryo, Nonmammalian / drug effects; Enzyme Inhibitors / administration & dosage; Enzyme Inhibitors / toxicity; Female; In Vitro Techniques; Lethal Dose 50; Marine Toxins; Maternal Exposure / adverse effects; Mice; Microcystins; Peptides, Cyclic / administration & dosage; Peptides, Cyclic / toxicity; Survival Rate; Toxicity Tests, Acute
TL;DR:
Data indicate that microcystin does not appear to affect development adversely in the mouse (in vivo or in vitro) or the toad at the doses and exposure parameters used.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 article
The hepatic endothelial carcinogen riddelliine induces endothelial apoptosis, mitosis, S phase, and p53 and hepatocytic vascular endothelial growth factor expression after short-term exposure
Nyska, A., Moomaw, C. R., Foley, J. F., Maronpot, R. R., Malarkey, D. E., Cummings, C. A., … Chan, P. C. (2002, November 1). TOXICOLOGY AND APPLIED PHARMACOLOGY, Vol. 184, pp. 153–164.
author keywords: pyrrolizidine alkaloid; endothelium; hemangiosarcoma; cytotoxicity; vascular endothelial growth factor; VEGFR2; BrdU; factor VIII-related antigen; von Willebrand factor; p53
MeSH headings : Administration, Oral; Animals; Apoptosis / drug effects; Bromodeoxyuridine / metabolism; Carcinogens / administration & dosage; Carcinogens / toxicity; Dose-Response Relationship, Drug; Endothelial Growth Factors / blood; Hepatocytes / drug effects; Hepatocytes / metabolism; Hepatocytes / pathology; Immunoenzyme Techniques; Intercellular Signaling Peptides and Proteins / blood; Kupffer Cells / drug effects; Kupffer Cells / metabolism; Kupffer Cells / pathology; Liver / drug effects; Liver / metabolism; Liver / pathology; Lymphokines / blood; Male; Mitosis; Pyrrolizidine Alkaloids / administration & dosage; Pyrrolizidine Alkaloids / toxicity; Rats; Rats, Inbred F344; S Phase / drug effects; Tumor Suppressor Protein p53 / metabolism; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 / metabolism; Vascular Endothelial Growth Factors; von Willebrand Factor / metabolism
TL;DR:
These changes may have promoted hemangiosarcoma development upon long-term exposure through endothelial adduct formation, apoptosis, proliferation of endothelial cells having undamaged and/or damaged DNA, and mutation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2001 journal article
Natural history of hypertrophic cardiomyopathy and aortic thromboembolism in a family of domestic shorthair cats
JOURNAL OF VETERINARY INTERNAL MEDICINE, 15(6), 595–599.
author keywords: cardiac myocyte disarray; end stage; spontaneous echo contrast; systolic function; ventricular remodeling
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2000 journal article
Histologic and immunohistochemical characterization of lens capsular plaques in dogs with cataracts
AMERICAN JOURNAL OF VETERINARY RESEARCH, 61(2), 139–143.
MeSH headings : Actins / analysis; Animals; Cataract / pathology; Cataract / veterinary; Cataract Extraction / veterinary; Dog Diseases / pathology; Dogs; Fibronectins / analysis; Histocytochemistry; Humans; Immunohistochemistry / methods; Lens, Crystalline / pathology; Lens, Crystalline / ultrastructure; Tenascin / analysis; Transforming Growth Factor beta / analysis
TL;DR:
Canine lens capsular plaques are histologically and immunohistochemically similar to posterior capsule opacification and subcapsular cataracts in humans, which suggests that the canine condition, like the human conditions, is associated with fibrous metaplasia of lens epithelial cells.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Persistent hyperplastic tunica vasculosa lentis and persistent hyperplastic primary vitreous in transgenic line TgN3261Rpw
VETERINARY PATHOLOGY, 37(5), 422–427.
author keywords: embryology; eye; mice; persistent hyperplastic primary vitreous; persistent hyperplastic tunica vasculosa lentis
MeSH headings : Animals; Blotting, Southern / veterinary; Dog Diseases / pathology; Dogs; Eye Abnormalities / pathology; Eye Abnormalities / veterinary; Hyperplasia / pathology; Hyperplasia / veterinary; Lens, Crystalline / abnormalities; Lens, Crystalline / embryology; Mice; Mice, Mutant Strains / embryology; Mice, Transgenic / embryology; Mutagenesis, Insertional; Vitreous Body / abnormalities; Vitreous Body / embryology
TL;DR:
A line of insertional mutant mice, TgN3261Rpw, generated at the Oak Ridge National Laboratory in a large-scale insertional mutagenesis program was found to have a low incidence of multiple developmental ocular abnormalities.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1999 journal article
Altered bcl-2 family expression during non-genotoxic hepatocarcinogenesis in mice
CARCINOGENESIS, 20(8), 1583–1590.
MeSH headings : Adenoma / chemically induced; Adenoma / metabolism; Adenoma / pathology; Animals; Apoptosis; Carcinogens; Carcinoma / chemically induced; Carcinoma / metabolism; Carcinoma / pathology; Carrier Proteins / metabolism; Chlordan; DNA-Binding Proteins; Liver Neoplasms, Experimental / chemically induced; Liver Neoplasms, Experimental / metabolism; Liver Neoplasms, Experimental / pathology; Male; Mice; Neoplasm Proteins / metabolism; Phenobarbital; Phenotype; Polychlorinated Dibenzodioxins; Proto-Oncogene Proteins / metabolism; Proto-Oncogene Proteins c-bcl-2 / metabolism; Pyrimidines; Transcription Factors; bcl-2-Associated X Protein; bcl-X Protein
TL;DR:
The results suggest that regulation of apoptotic proteins is altered during non-genotoxic carcinogenesis in mouse liver and there were both chemical- and lesion-specific aspects of expression of apoptosis proteins during hepatocarcinogenesis in mice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
11. Sustainable Cities and Communities
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1998 journal article
Association of v-Ha-ras transgene expression with development of erythroleukemia in Tg.AC transgenic mice
AMERICAN JOURNAL OF PATHOLOGY, 153(1), 247–254.
MeSH headings : Animals; Blood Cell Count; Blood Cells / metabolism; Bone Marrow / metabolism; DNA-Binding Proteins / metabolism; Erythroid-Specific DNA-Binding Factors; GATA1 Transcription Factor; Genes, ras / genetics; Globins / metabolism; Leukemia, Erythroblastic, Acute / genetics; Leukemia, Erythroblastic, Acute / metabolism; Leukemia, Erythroblastic, Acute / pathology; Liver / metabolism; Liver / pathology; Mice; Mice, Transgenic; Organ Size; Polymerase Chain Reaction; Spleen / metabolism; Spleen / pathology; Transcription Factors / metabolism; Transcription, Genetic; ras Proteins / metabolism
TL;DR:
The morphological, immunophenotypic, and molecular features of a unique hematopoietic neoplasm in these mice are described, supporting the belief that the zeta-globin promoter directs v-Ha-ras expression in erythroid progenitor cells, ultimately leading to leukemic transformation.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
1998 journal article
Effect of the viable-yellow (A(vy)) agouti allele on skin tumorigenesis and humoral hypercalcemia in v-Ha-ras transgenic TG.AC mice
CARCINOGENESIS, 19(10), 1837–1845.
MeSH headings : Agouti Signaling Protein; Alleles; Animals; Base Sequence; Body Weight; DNA Primers; Genes, ras; Hypercalcemia / complications; Hypercalcemia / genetics; Intercellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Papilloma / chemically induced; Papilloma / complications; Papilloma / genetics; Proteins / genetics; Skin Neoplasms / chemically induced; Skin Neoplasms / complications; Skin Neoplasms / genetics; Tetradecanoylphorbol Acetate / toxicity
TL;DR:
It is concluded that the A(vy) allele can influence the development of skin tumors and PTHrP-mediated humoral hypercalcemia in v-Ha-ras transgenic TGxAC mice.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
1998 journal article
Impact of Helicobacter hepaticus infection in B6C3F(1) mice from twelve national toxicology program two-year carcinogenesis studies
TOXICOLOGIC PATHOLOGY, 26(5), 602–611.
author keywords: liver neoplasia; mice; hemangiosarcoma; cell proliferation; H-ras; hepatitis
MeSH headings : Animals; Carcinogenicity Tests; Cell Cycle / physiology; Female; Genes, ras; Helicobacter; Helicobacter Infections / complications; Hepatitis / microbiology; Liver Neoplasms, Experimental / genetics; Liver Neoplasms, Experimental / microbiology; Male; Mice; Mice, Inbred Strains; Mutation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Rats; Rats, Inbred F344
TL;DR:
Data support the hypothesis that the increased incidence of liver neoplasms is associated with H. hepaticus and that hepatitis may be important in the pathogenesis and interpretation of carcinogenic effects in the liver of B6C3F1 mice may be confounded if there is H. liveraticus-associaled hepatitis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1998 journal article
Spontaneous and chemically induced proliferative lesions in Tg.AC transgenic and p53-heterozygous mice
TOXICOLOGIC PATHOLOGY, 26(4), 501–511.
author keywords: mice; genetically altered; hazard identification; neoplasms; carcinogenicity
MeSH headings : Animals; Carcinogenicity Tests / methods; Carcinogens / toxicity; Genes, p53 / genetics; Heterozygote; Mice; Mice, Transgenic / genetics; Mice, Transgenic / physiology; Neoplasms, Experimental / chemically induced; Neoplasms, Experimental / genetics; Neoplasms, Experimental / pathology
TL;DR:
The proliferative target organ effects observed in this set of studies are described and the tumor profile in the control groups of this data set is presented to provide a comprehensive toxicologic assessment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1997 journal article
A PCR-RFLP method for the detection of Helicobacter hepaticus in frozen or fixed liver from B6C3F(1) mice
TOXICOLOGIC PATHOLOGY, 25(6), 606–612.
author keywords: mouse liver carcinogenesis; diagnostic assay; archival tissues; sensitivity; specificity; bioassay; National Toxicology Program (NTP)
MeSH headings : Animals; DNA, Bacterial / analysis; Female; Formaldehyde; Frozen Sections; Helicobacter / genetics; Helicobacter Infections / pathology; Liver / microbiology; Liver / pathology; Male; Mice; Mice, Inbred Strains; Paraffin Embedding; Polymerase Chain Reaction / methods; Polymorphism, Restriction Fragment Length; Tissue Fixation
TL;DR:
The sensitivity of the PCR-RFLP assay for H. hepaticus on formalin-fixed, paraffin-embedded mouse liver varied between studies from markedly decreased when compared to the results from frozen liver or histologic evaluation to nearly equivalent or more sensitive than Histologic evaluation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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