Dmytro Havrylyuk

Havrylyuk, D., Heidary, D. K., & Glazer, E. C. (2024). The Impact of Inorganic Systems and Photoactive Metal Compounds on Cytochrome P450 Enzymes and Metabolism: From Induction to Inhibition. Biomolecules. https://doi.org/10.3390/biom14040441

Cole, H. D., Roque, J. A., III, Lifshits, L. M., Hodges, R., Barrett, P. C., Havrylyuk, D., … McFarland, S. A. (2022). Fine‐Feature Modifications to Strained Ruthenium Complexes Radically Alter Their Hypoxic Anticancer Activity
            <sup>†. Photochemistry and Photobiology, 98(1), 73–84. https://doi.org/10.1111/php.13395

Havrylyuk, D., Hachey, A. C., Fenton, A., Heidary, D. K., & Glazer, E. C. (2022). Ru(II) photocages enable precise control over enzyme activity with red light. Nature Communications. https://doi.org/10.1038/s41467-022-31269-5

Havrylyuk, D., Heidary, D. K., & Glazer, E. C. (2022). Ru-PROTACs are a Promising Tool for the Photocontrol of Protein Degradation. Metals in Medicine, Gordon Research Conference. Presented at the Metals in Medicine, Gordon Research Conference.

Ryan, R. T., Havrylyuk, D., Stevens, K. C., Moore, L. H., Parkin, S., Blackburn, J. S., … Glazer, E. C. (2021). Biological Investigations of Ru(II) Complexes with Diverse β‐Diketone Ligands. European Journal of Inorganic Chemistry, 2021(35), 3611–3621. https://doi.org/10.1002/ejic.202100468

Hachey, A. C., Havrylyuk, D., & Glazer, E. C. (2021). Biological activities of polypyridyl-type ligands: implications for bioinorganic chemistry and light-activated metal complexes. Current Opinion in Chemical Biology, 61, 191–202. https://doi.org/10.1016/j.cbpa.2021.01.016

Ryan, R. T., Havrylyuk, D., Stevens, K. C., Moore, L. H., Kim, D. Y., Blackburn, J. S., … Glazer, E. C. (2020). Avobenzone incorporation in a diverse range of Ru(<scp>ii</scp>) scaffolds produces potent potential antineoplastic agents. Dalton Transactions, 49(35), 12161–12167. https://doi.org/10.1039/d0dt02016h

Havrylyuk, D., Heidary, D. K., Sun, Y., Parkin, S., & Glazer, E. C. (2020). Photochemical and Photobiological Properties of Pyridyl-pyrazol(in)e-Based Ruthenium(II) Complexes with Sub-micromolar Cytotoxicity for Phototherapy. ACS Omega, 5(30), 18894–18906. https://doi.org/10.1021/acsomega.0c02079

Roque, J., III, Havrylyuk, D., Barrett, P. C., Sainuddin, T., McCain, J., Colón, K., … McFarland, S. A. (2020). Strained, Photoejecting Ru(II) Complexes that are Cytotoxic Under Hypoxic Conditions. Photochemistry and Photobiology, 96(2), 327–339. https://doi.org/10.1111/php.13174

Havrylyuk, D., Stevens, K., Parkin, S., & Glazer, E. C. (2020). Toward Optimal Ru(II) Photocages: Balancing Photochemistry, Stability, and Biocompatibility Through Fine Tuning of Steric, Electronic, and Physiochemical Features. Inorganic Chemistry, 59(2), 1006–1013. https://doi.org/10.1021/acs.inorgchem.9b02065

Havrylyuk, D., Stevens, K., Denning, C. A., Heidary, D. K., & Glazer, E. C. (2018). Ru(II) CYP1B1 Inhibitor Prodrugs with Enhanced Potency. Metals in Medicine, Gordon Research Conference. Presented at the Gordon Research Conference.

Havrylyuk, D., Deshpande, M., Parkin, S., & Glazer, E. C. (2018). Ru(ii) complexes with diazine ligands: electronic modulation of the coordinating group is key to the design of “dual action” photoactivated agents. Chemical Communications, 54(88), 12487–12490. https://doi.org/10.1039/C8CC05809A

Havrylyuk, D., Howerton, B. S., Nease, L., Parkin, S., Heidary, D. K., & Glazer, E. C. (2018). Structure-activity relationships of anticancer ruthenium(II) complexes with substituted hydroxyquinolines. European Journal of Medicinal Chemistry, 156, 790–799. https://doi.org/10.1016/j.ejmech.2018.04.044

Havrylyuk, D., Heidary, D. K., Nease, L., Parkin, S., & Glazer, E. C. (2017). Back Cover: Photochemical Properties and Structure–Activity Relationships of RuII Complexes with Pyridylbenzazole Ligands as Promising Anticancer Agents (Eur. J. Inorg. Chem. 12/2017). European Journal of Inorganic Chemistry. https://doi.org/10.1002/ejic.201700259

Havrylyuk, D., Heidary, D. K., Nease, L., Parkin, S., & Glazer, E. C. (2017). Photochemical Properties and Structure–Activity Relationships of RuII Complexes with Pyridylbenzazole Ligands as Promising Anticancer Agents. European Journal of Inorganic Chemistry, 2017(12), 1687–1694. https://doi.org/10.1002/ejic.201601450

Havrylyuk, D., Howerton, B. S., Nease, L., Heidary, D. K., & Glazer, E. C. (2016). Synthesis, SAR analysis and Mechanistic Studies of New 2-R-Methyl-8-hydroxyquinoline Based Ruthenium(II) Complexes with Promising Antitumor Activity. 2nd Annual Postdoctoral Research Symposium. Presented at the 2nd Annual Postdoctoral Research Symposium, Lexington, KY.

Kobylinska, L. I., Havrylyuk, D. Y., Ryabtseva, A. O., Mitina, N. E., Zaichenko, O. S., Lesyk, R. B., … Stoika, R. S. (2015). BIOCHEMICAL INDICATORS OF HEPATOTOXICITY IN BLOOD SERUM OF RATS UNDER THE EFFECT OF NOVEL 4-THIAZOLIDINONE DERIVATIVES AND DOXORUBICIN AND THEIR COMPLEXES WITH POLYETHYLENEGLYCOL-CONTAINING NANOSCALE POLYMERIC CARRIER. Ukrainian Biochemical Journal, 87(2), 122–132. Retrieved from http://www.scopus.com/inward/record.url?eid=2-s2.0-84940029286&partnerID=MN8TOARS

Havrylyuk, D., Zimenkovsky, B., & Lesyk, R. (2015). Synthesis, Biological activity of thiazolidinones bearing indoline moiety and isatin based hybrids. Mini-Reviews in Organic Chemistry, 12(1), 66–87. Retrieved from http://www.scopus.com/inward/record.url?eid=2-s2.0-84920862003&partnerID=MN8TOARS

Devinyak, O., Havrylyuk, D., & Lesyk, R. (2014). 3D-MoRSE descriptors explained. Journal of Molecular Graphics and Modelling, 54, 194–203. https://doi.org/10.1016/j.jmgm.2014.10.006

Avdieiev, S., Gera, L., Havrylyuk, D., Hodges, R. S., Lesyk, R., Ribrag, V., … Kavsan, V. (2014). Bradykinin antagonists and thiazolidinone derivatives as new potential anti-cancer compounds. Bioorganic and Medicinal Chemistry, 22(15), 3815–3823. https://doi.org/10.1016/j.bmc.2014.06.046

Devinyak, O., Havrylyuk, D., Zimenkovsky, B., & Lesyk, R. (2014). Computational search for possible mechanisms of 4-thiazolidinones anticancer activity: The power of visualization. Molecular Informatics, 33(3), 216–229. https://doi.org/10.1002/minf.201300086

Chumak, V. V., Fil, M. R., Panchuk, R. R., Zimenkovsky, B. S., Havrylyuk, D. Y., Lesyk, R. B., & Stoika, R. S. (2014). Study of antineoplastic action of novel isomeric derivatives of 4-thiazolidinone. Ukrainian Biochemical Journal, 86(6), 96–105. Retrieved from http://www.scopus.com/inward/record.url?eid=2-s2.0-84938071889&partnerID=MN8TOARS

Havrylyuk, D., Zimenkovsky, B., Karpenko, O., Grellier, P., & Lesyk, R. (2014). Synthesis of pyrazoline-thiazolidinone hybrids with trypanocidal activity. European Journal of Medicinal Chemistry, 85, 245–254. https://doi.org/10.1016/j.ejmech.2014.07.103

Devinyak, O. T., Havrylyuk, D. Y. A., Avdieiev, S. S., Chumak, V. V., Panchuk, R. R., Stoika, R. S., … Lesyk, R. B. (2014). Virtual screening and its experimental validation reveal novel compounds with promising anticancer activity among 4-thiazolidinone- pyrazoline- and isatin-based conjugates. Austin Journal of Bioorganic & Organic Chemistry, 1(1), 6.

Havrylyuk, D., Zimenkovsky, B., Vasylenko, O., & Lesyk, R. (2013). Synthesis and anticancer and antiviral activities of new 2-pyrazoline-substituted 4-thiazolidinones. Journal of Heterocyclic Chemistry, 50(SUPPL.1). https://doi.org/10.1002/jhet.1056

Havrylyuk, D., Zimenkovsky, B., Vasylenko, O., Day, C. W., Smee, D. F., Grellier, P., & Lesyk, R. (2013). Synthesis and biological activity evaluation of 5-pyrazoline substituted 4-thiazolidinones. European Journal of Medicinal Chemistry, 66, 228–237. https://doi.org/10.1016/j.ejmech.2013.05.044

Harkov, S., Havrylyuk, D., Atamanyuk, V., Zimenkovsky, B., & Lesyk, R. (2013). Synthesis and biological activity of isatines bearing thiazolidinone and pyrazoline moieties. Pharmacia, 60(1), 8–18. Retrieved from http://www.scopus.com/inward/record.url?eid=2-s2.0-84888407984&partnerID=MN8TOARS

Harkov, S., Havrylyuk, D., & Lesyk, R. (2013). Synthesis of 3S-substituted triazino[5,6-b]indoles and 4-thiazolidinone-triazino[5,6-b]indole hybrids with antitumor activity. Chemistry and Chemical Technology, 7(4), 381–389. Retrieved from http://www.scopus.com/inward/record.url?eid=2-s2.0-84897827225&partnerID=MN8TOARS

Panchuk, R. R., Chumak, V. V., Fil, M. R., Havrylyuk, D. Y., Zimenkovsky, B. S., Lesyk, R. B., & Stoika, R. S. (2012). Study of molecular mechanisms of proapoptotic action of novel heterocyclic 4-thiazolidone derivatives. Biopolymers and Cell, 28(2), 121–128. https://doi.org/10.7124/bc.00003D

Havrylyuk, D., Zimenkovsky, B., Vasylenko, O., Gzella, A., & Lesyk, R. (2012). Synthesis of new 4-thiazolidinone-, pyrazoline-, and isatin-based conjugates with promising antitumor activity. Journal of Medicinal Chemistry, 55(20), 8630–8641. https://doi.org/10.1021/jm300789g

Sklyarov, A. Y., Lesyk, R. B., Panasyuk, N. B., Fomenko, I. S., & Havrylyuk, D. Y. (2011). Comparison of dual acting drugs and conventional NSAIDs towards parameters of NO-synthase system and oxidative stress in mucosal membrane of large intestine of rats with experimental ulcerative colitis. Biopolymers and Cell, 27(2), 147–153. Retrieved from http://www.scopus.com/inward/record.url?eid=2-s2.0-79957764684&partnerID=MN8TOARS

Havrylyuk, D., Zimenkovsky, B., & Lesyk, R. (2011). Design, synthesis and antitumor activity screening of novel heterocyclic derivatives of 4-thiazolidinones based on the hybrid pharmacophore approach. Bridges in Life Sciences: 6th Annual Scientific Meeting RECOOP HST. Presented at the 6th Annual Scientific Meeting RECOOP HST, Bratislava, Slovak Republic.

Havrylyuk, D., Kovach, N., Zimenkovsky, B., Vasylenko, O., & Lesyk, R. (2011). Synthesis and anticancer activity of isatin-based pyrazolines and thiazolidines conjugates. Archiv Der Pharmazie, 344(8), 514–522. https://doi.org/10.1002/ardp.201100055

Lesyk, R. B., Zimenkovsky, B. S., Kaminskyy, D. V., Kryshchyshyn, A. P., Havryluk, D. Y., Atamanyuk, D. V., … Khyluk, D. V. (2011). Thiazolidinone motif in anticancer drug discovery. Experience of DH LNMU medicinal chemistry scientific group. Biopolymers and Cell, 27(2), 107–117. Retrieved from http://www.scopus.com/inward/record.url?eid=2-s2.0-79957671997&partnerID=MN8TOARS

Havrylyuk, D., Mosula, L., Zimenkovsky, B., Vasylenko, O., Gzella, A., & Lesyk, R. (2010). Synthesis and anticancer activity evaluation of 4-thiazolidinones containing benzothiazole moiety. European Journal of Medicinal Chemistry, 45(11), 5012–5021. https://doi.org/10.1016/j.ejmech.2010.08.008

Havrylyuk, D., Zimenkovsky, B., & Lesyk, R. (2010). Synthesis and antitumor activity of thiazolidinones with pyrazoline moiety.Streszczenia farmacja polska na tle unii europejskiej. XXI Naukowy Zjazd Polskiego Towarzystwa Farmaceutycznego Gdansk, Poland. Presented at the XXI Naukowy Zjazd Polskiego Towarzystwa Farmaceutycznego Gdansk, Poland.

Havrylyuk, D., Kovach, N., Zimenkovsky, B., & Lesyk, R. (2010). Synthesis of new 4-azolidinones with 3,5-diaryl-4,5-dihydropyrazole moiety and evaluation of their antitumor activity in vitro. Annales Universitatis Mariae Curie-Sklodowska, Sectio DDD: Pharmacia, 23(3), 173–177. Retrieved from http://www.scopus.com/inward/record.url?eid=2-s2.0-84860479489&partnerID=MN8TOARS

Havrylyuk, D., Zimenkovsky, B., & Lesyk, R. (2009). Synthesis and anticancer activity of novel nonfused bicyclic thiazolidinone derivatives. Phosphorus, Sulfur and Silicon and the Related Elements, 184(3), 638–650. https://doi.org/10.1080/10426500802247563

Mosula, L., Zimenkovsky, B., Havrylyuk, D., Missir, A.-V., Chiriţǎ, I. C., & Lesyk, R. (2009). Synthesis and antitumor activity of novel 2-thioxo-4-thiazolidinones with benzothiazole moieties. Farmacia, 57(3), 321–330. Retrieved from http://www.scopus.com/inward/record.url?eid=2-s2.0-69249231104&partnerID=MN8TOARS

Havrylyuk, D., Zimenkovsky, B., Vasylenko, O., Zaprutko, L., Gzella, A., & Lesyk, R. (2009). Synthesis of novel thiazolone-based compounds containing pyrazoline moiety and evaluation of their anticancer activity. European Journal of Medicinal Chemistry, 44(4), 1396–1404. https://doi.org/10.1016/j.ejmech.2008.09.032