Works (3)
Updated: July 5th, 2023 15:43
2021 journal article
Epithelial-specific ERBB3 deletion results in a genetic background-dependent increase in intestinal and colon polyps that is mediated by EGFR
PLOS GENETICS, 17(11).
MeSH headings : Adenomatous Polyposis Coli Protein / genetics; Animals; Cell Proliferation / genetics; Colon / metabolism; Colon / pathology; Colonic Polyps / genetics; Colonic Polyps / pathology; Colonic Polyps / therapy; Colorectal Neoplasms / genetics; Colorectal Neoplasms / pathology; Colorectal Neoplasms / therapy; Disease Models, Animal; ErbB Receptors / genetics; Gene Expression Regulation, Neoplastic / genetics; Gene Silencing; Humans; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Intestinal Polyps / genetics; Intestinal Polyps / pathology; Intestinal Polyps / therapy; Mice; Receptor, ErbB-3 / antagonists & inhibitors; Receptor, ErbB-3 / genetics
TL;DR:
Increase polyp number caused by loss of ERBB3 was mediated by increased epidermal growth factor receptor (EGFR) expression, which was confirmed by deletion of Egfr.
(via Semantic Scholar)
journals.plos.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: December 13, 2021
2017 journal article
Prophylactic vaccination targeting erbb3 decreases polyp burden in a mouse model of human colorectal cancer
Oncoimmunology, 6(1).
Source: NC State University Libraries
Added: August 6, 2018
2013 journal article
Identification of a Novel Polymorphism in X-Linked Sterol-4-Alpha-Carboxylate 3-Dehydrogenase (Nsdhl) Associated with Reduced High-Density Lipoprotein Cholesterol Levels in I/LnJ Mice
G3-GENES GENOMES GENETICS, 3(10), 1819–1825.
author keywords: QTL; genomics; HDL cholesterol; Nsdhl
MeSH headings : 3-Hydroxysteroid Dehydrogenases / genetics; Animals; Animals, Inbred Strains; Apolipoprotein A-II / genetics; Cholesterol, HDL / blood; Cholesterol, HDL / genetics; Genetic Linkage; Lipid Metabolism / genetics; Mice; Polymorphism, Single Nucleotide; Quantitative Trait Loci; X Chromosome / genetics
TL;DR:
There are additional genes left to be identified that control lipid levels and that can provide new pharmaceutical targets, including sterol-4-alpha-carboxylate 3-dehydrogenase in the cholesterol synthesis pathway.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.
Certain data included herein are derived from the Web of Science© and InCites© (2024) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.
