David J. Bautz

Works (3)

Updated: July 5th, 2023 15:43

2021 article

Epithelial-specific ERBB3 deletion results in a genetic background-dependent increase in intestinal and colon polyps that is mediated by EGFR

Rojas, C. M., McGill, M. P., Salvador, A. C., Bautz, D., & Threadgill, D. W. (2021, November 29). PLoS Genetics.

By: C. Rojas *, M. McGill *, A. Salvador *, D. Bautz n & D. Threadgill*

MeSH headings : Adenomatous Polyposis Coli Protein / genetics; Animals; Cell Proliferation / genetics; Colon / metabolism; Colon / pathology; Colonic Polyps / genetics; Colonic Polyps / pathology; Colonic Polyps / therapy; Colorectal Neoplasms / genetics; Colorectal Neoplasms / pathology; Colorectal Neoplasms / therapy; Disease Models, Animal; ErbB Receptors / genetics; Gene Expression Regulation, Neoplastic / genetics; Gene Silencing; Humans; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Intestinal Polyps / genetics; Intestinal Polyps / pathology; Intestinal Polyps / therapy; Mice; Receptor, ErbB-3 / antagonists & inhibitors; Receptor, ErbB-3 / genetics
topics (OpenAlex): Pancreatic and Hepatic Oncology Research; Drug Transport and Resistance Mechanisms; Neuroendocrine Tumor Research Advances
TL;DR: Increase polyp number caused by loss of ERBB3 was mediated by increased epidermal growth factor receptor (EGFR) expression, which was confirmed by deletion of Egfr. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: December 13, 2021

2017 journal article

Prophylactic vaccination targeting erbb3 decreases polyp burden in a mouse model of human colorectal cancer

Oncoimmunology, 6(1).

By: D. Bautz, A. Sherpa & D. Threadgill

Source: NC State University Libraries
Added: August 6, 2018

2013 article

Identification of a Novel Polymorphism in X-Linked Sterol-4-Alpha-Carboxylate 3-Dehydrogenase (Nsdhl) Associated with Reduced High-Density Lipoprotein Cholesterol Levels in I/LnJ Mice

Bautz, D. J., Broman, K. W., & Threadgill, D. W. (2013, August 27). G3 Genes Genomes Genetics.

By: D. Bautz n, K. Broman * & D. Threadgill n

author keywords: QTL; genomics; HDL cholesterol; Nsdhl
MeSH headings : 3-Hydroxysteroid Dehydrogenases / genetics; Animals; Animals, Inbred Strains; Apolipoprotein A-II / genetics; Cholesterol, HDL / blood; Cholesterol, HDL / genetics; Genetic Linkage; Lipid Metabolism / genetics; Mice; Polymorphism, Single Nucleotide; Quantitative Trait Loci; X Chromosome / genetics
topics (OpenAlex): Cholesterol and Lipid Metabolism; Peroxisome Proliferator-Activated Receptors; Lipid metabolism and biosynthesis
TL;DR: There are additional genes left to be identified that control lipid levels and that can provide new pharmaceutical targets, including sterol-4-alpha-carboxylate 3-dehydrogenase in the cholesterol synthesis pathway. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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