Works (12)
Updated: July 5th, 2023 15:38
2020 journal article
Sirtuin 5 Is Regulated by the SCFCyclin (F) Ubiquitin Ligase and Is Involved in Cell Cycle Control
MOLECULAR AND CELLULAR BIOLOGY, 41(2).
author keywords: cyclin F (CCNF); sirtuin 5 (SIRT5); cell cycle; ubiquitin; metabolism; SCF
MeSH headings : Cell Cycle / genetics; Cell Cycle Proteins / genetics; Cell Cycle Proteins / metabolism; F-Box Proteins / genetics; F-Box Proteins / metabolism; Gene Expression Profiling; Gene Expression Regulation, Fungal; Genes, Lethal; HEK293 Cells; HeLa Cells; Humans; Mutation; Protein Processing, Post-Translational; SKP Cullin F-Box Protein Ligases / genetics; SKP Cullin F-Box Protein Ligases / metabolism; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Saccharomyces cerevisiae Proteins / genetics; Saccharomyces cerevisiae Proteins / metabolism; Signal Transduction; Sirtuins / genetics; Sirtuins / metabolism; Ubiquitin-Protein Ligases / genetics; Ubiquitin-Protein Ligases / metabolism; Ubiquitination
TL;DR:
It is shown that cyclin F interacts with and controls the ubiquitination, abundance, and stability of SIRT5, which is a mitochondrial and cytosolic deacylating enzyme that has been implicated in metabolic processes, but its connection to the cell cycle is not known.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: March 15, 2021
2016 journal article
APC/C and SCFcyclin F Constitute a Reciprocal Feedback Circuit Controlling S-Phase Entry
CELL REPORTS, 16(12), 3359–3372.
MeSH headings : Anaphase-Promoting Complex-Cyclosome / metabolism; Cyclins / metabolism; Feedback, Physiological / physiology; HEK293 Cells; HeLa Cells; Humans; S Phase / physiology
TL;DR:
A reciprocal feedback circuit between APC/C and a second ubiquitin ligase, the SCF, is described and it is shown that cyclin F, a cell-cycle-regulated substrate receptor for the SCF, is targeted for degradation by APC/C.
(via Semantic Scholar)
open access via doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Connecting the microtubule attachment status of each kinetochore to cell cycle arrest through the spindle assembly checkpoint
Chromosoma, 124(4), 463–480.
author keywords: Mitosis; Mitotic checkpoint; Chromosome segregation; Cell division
MeSH headings : Animals; DNA Damage; Eukaryota; Humans; Kinetochores / physiology; M Phase Cell Cycle Checkpoints / physiology; Microtubules; Spindle Apparatus
TL;DR:
The molecular mechanisms by which kinetochores generate the spindle assembly checkpoint (SAC) and extinguish the signal after making proper attachments are reviewed, with the goal of identifying unanswered questions and new research directions.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2013 journal article
31
Cytokine, 63(3), 250.
TL;DR:
It is demonstrated that IFN regulation of glucose uptake is required for an antiviral response to infection with the cardiotropic virus, coxsackievirus B3 (CVB3), and evidence is provided for IFN regulated increases in ATP production.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2013 journal article
Unbiased segregation of yeast chromatids in Saccharomyces cerevisiae
Chromosome Research, 21(3), 193–202.
author keywords: mitosis; chromosomes; chromatids; immortal strand; strand-specific imprinting
MeSH headings : Chromatids / metabolism; Chromosome Segregation; Mitosis; Saccharomyces cerevisiae / cytology; Saccharomyces cerevisiae / genetics
TL;DR:
The special aspects of spindle morphogenesis and behavior in yeast that could accommodate a mechanism for biased segregation are discussed and a recent experiment demonstrated that yeast chromatids segregate randomly without mother–daughter bias in a common laboratory strain grown under routine laboratory conditions.
(via Semantic Scholar)
Source: Crossref
Added: November 17, 2020
2009 journal article
Irc15 Is a Microtubule-Associated Protein that Regulates Microtubule Dynamics in Saccharomyces cerevisiae
Current Biology, 19(6), 472–478.
MeSH headings : Chromosomes, Fungal / genetics; Conserved Sequence; Cytoplasm / physiology; Dihydrolipoamide Dehydrogenase / genetics; Genes, Reporter; Glycolysis; Homeostasis; Microtubule-Associated Proteins / genetics; Microtubule-Associated Proteins / physiology; Microtubules / physiology; Microtubules / ultrastructure; Mutation; Saccharomyces cerevisiae / cytology; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / physiology; Saccharomyces cerevisiae Proteins / genetics; Saccharomyces cerevisiae Proteins / physiology; Stress, Mechanical
TL;DR:
Evidence is presented that Irc15 regulates microtubule dynamics in vivo and loss of IRC15 function leads to delayed mitotic progression, resulting from failure to establish tension between sister kinetochores.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2008 journal article
Linking Kinetochore-Microtubule Binding to the Spindle Checkpoint
Developmental Cell, 14(4), 474–479.
MeSH headings : Animals; Cell Cycle / physiology; Cell Cycle Proteins / genetics; Cell Cycle Proteins / metabolism; Genes, cdc; Humans; Kinetochores / metabolism; Microtubules / metabolism; Models, Biological; Protein Binding; Protein Kinases / metabolism; Signal Transduction / physiology; Spindle Apparatus / metabolism
TL;DR:
The spindle checkpoint blocks cell-cycle progression until chromosomes are properly attached to the mitotic spindle, arguing that a traditional signal transduction cascade is integral to spindle checkpoints signaling.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2008 journal article
The Immortal Strand Hypothesis: How Could It Work?
Cell, 133(1), 21–23.
MeSH headings : Animals; Chromosome Segregation; DNA Replication; Humans; Kinetochores; Stem Cells / cytology; Stem Cells / metabolism
TL;DR:
The “immortal strand” hypothesis holds that when stem cells undergo asymmetric cell division, one daughter (the self-renewing stem cell) selectively retains the older template DNA strand from each chromosome.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2007 journal article
A Hec of a microtubule attachment
Nature Structural & Molecular Biology, 14(1), 11–13.
MeSH headings : Animals; Crystallography, X-Ray; Cytoskeletal Proteins; Humans; Kinetochores / metabolism; Microtubules / metabolism; Mitosis; Nuclear Proteins / chemistry; Nuclear Proteins / metabolism; Protein Conformation; Protein Structure, Tertiary; Spindle Apparatus / metabolism
TL;DR:
Structural, biochemical and cell biological approaches have converged to uncover a microtubule-binding activity within the Ndc80/HEC1 complex, providing a satisfying answer to a question that has puzzled biologists for the last century.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2007 journal article
Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry
Proceedings of the National Academy of Sciences, 104(7), 2193–2198.
author keywords: yeast phosphoproteome; network analysis
MeSH headings : Binding Sites; Phosphoproteins / analysis; Phosphoproteins / chemistry; Phosphoproteins / metabolism; Phosphorylation; Phosphotransferases / analysis; Phosphotransferases / chemistry; Phosphotransferases / metabolism; Protein Binding; Proteomics / methods; Saccharomyces cerevisiae Proteins / analysis; Saccharomyces cerevisiae Proteins / chemistry; Saccharomyces cerevisiae Proteins / metabolism; Tandem Mass Spectrometry / methods
TL;DR:
It is shown that phosphoproteins have a higher number of interactions than an average protein and interact with each other more than with a random protein, and are likely to be conserved across large evolutionary distances.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2006 journal article
Pmr1, a Golgi Ca2+/Mn2+-ATPase, is a regulator of the target of rapamycin (TOR) signaling pathway in yeast
Proceedings of the National Academy of Sciences, 103(47), 17840–17845.
MeSH headings : Amino Acid Transport Systems / genetics; Amino Acid Transport Systems / metabolism; Antifungal Agents / metabolism; Calcium-Transporting ATPases / genetics; Calcium-Transporting ATPases / metabolism; Epistasis, Genetic; Gene Expression Regulation, Fungal; Golgi Apparatus / enzymology; Molecular Chaperones / genetics; Molecular Chaperones / metabolism; Protein Kinases / genetics; Protein Kinases / metabolism; Protein Serine-Threonine Kinases; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / metabolism; Saccharomyces cerevisiae / cytology; Saccharomyces cerevisiae / enzymology; Saccharomyces cerevisiae Proteins / genetics; Saccharomyces cerevisiae Proteins / metabolism; Signal Transduction / physiology; Sirolimus / metabolism; Transcription Factors / metabolism
TL;DR:
The results establish that Pmr1-dependent Ca2+ and/or Mn2+ ion homeostasis is necessary for TOR signaling, and suggest up-regulation of Npr1 function in the absence of Pmr
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2004 journal article
Analyses of the effects of Rck2p mutants on Pbs2pDD-induced toxicity in Saccharomyces cervisiae identify a MAP kinase docking motif, and unexpected functional inactivation due to acidic substitution of T379
Molecular Genetics and Genomics, 271(2), 208–219.
author keywords: yeast; RCK2; PBS2; HOG1; MAP kinases
MeSH headings : Alleles; Amino Acid Motifs / genetics; Amino Acid Sequence; Binding Sites / genetics; DNA Primers; Gene Deletion; Gene Expression Regulation, Fungal; Immunoblotting; Mitogen-Activated Protein Kinase Kinases / genetics; Mitogen-Activated Protein Kinases / metabolism; Molecular Sequence Data; Mutation, Missense / genetics; Plasmids / genetics; Precipitin Tests; Protein Serine-Threonine Kinases / genetics; Protein Serine-Threonine Kinases / metabolism; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / physiology; Saccharomyces cerevisiae Proteins / metabolism
TL;DR:
The structural and functional basis for the role of Rck2p in mediating the growth arrest phenotype associated with overexpression of Pbs2pDD is studied and the effect of replacing the predicted T379 and established S520 phosphorylation sites in Rck1p by glutamic acid is studied.
(via Semantic Scholar)
Source: Crossref
Added: November 17, 2020
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