@article{marcellin-little_deyoung_doyens_deyoung_1999, title={Canine uncemented porous-coated anatomic total hip arthroplasty: Results of a long-term prospective evaluation of 50 consecutive cases}, volume={28}, ISSN={["1532-950X"]}, DOI={10.1053/jvet.1999.0010}, abstractNote={Objective— To evaluate the long‐term clinical and radiographic results of a canine uncemented porous‐coated anatomic (PCA) total hip arthroplasty (THA). Study Design— Prospective study of consecutive clinical patients using survival analysis. Animals— Forty‐one dogs that underwent PCA THA; nine had bilateral PCA THA (50 prostheses). Methods— Gait observation, orthopedic examination, and radiographic assessment were conducted before THA, 6 months after THA, and yearly thereafter. A zonal analysis system was used to document osseous changes in the femur and the acetabulum. Acetabular cup and femoral stem subsidence and migration, femoral canal fill, and implant orientation were measured. Survival analysis of the procedure was conducted. Results— Long‐term follow‐up was available for 37 dogs (46 prostheses). The median follow‐up was 63 months. Limb function was normal for 37 limbs and abnormal for 9 limbs because of dislocation ( n = 3 ), lumbosacral disease ( n = 2 ), degenerative myelopathy ( n = 1 ), autoimmune disease ( n = 1 ), brain tumor ( n = 1 ), or osteosarcoma of the femur ( n = 1 ). All prosthetic stems and cups were fixed by bone ingrowth fixation. Osteolysis was not observed. Bone infarction occurred in five femoral canals (four dogs). The 6‐year survival rate for the procedure was 87% (95% confidence interval, 72%‐96%). Conclusions— Long‐term fixation of the uncemented PCA acetabular cup and stem is successful in dogs, and long‐term clinical function is excellent.}, number={1}, journal={VETERINARY SURGERY}, author={Marcellin-Little, DJ and DeYoung, BA and Doyens, DH and DeYoung, DJ}, year={1999}, pages={10–20} }
 @article{marcellin-little_deyoung_thrall_merrill_1999, title={Osteosarcoma at the site of bone infarction associated with total hip arthroplasty in a dog}, volume={28}, ISSN={["0161-3499"]}, DOI={10.1053/jvet.1999.0054}, abstractNote={Objective— To report the occurrence of medullary bone infarction in both femoral canals after bilateral total hip arthroplasty (THA) and the subsequent unilateral development of an osteosarcoma at the site of bone infarction. Study Design— Clinical report. Animal Population— An 8‐month‐old neutered male Samoyed dog. Methods— Serial physical and radiographic examinations performed at 1, 2, 3, and 5 years after THA. Bone biopsy specimens of the right distal femoral metaphysis were taken 5 years after THA, and a complete necropsy was performed at the time of euthanasia. Results— Bilateral medullary bone infarction was visible in the femoral canals 1 year after THA and remained visible on subsequent evaluations. An osteosarcoma developed in the right distal femoral metaphysis at the site of infarction, 5 years after THA, and was found to have metastasized widely throughout the body. Conclusion— Bone infarction may occur in the femoral canal after canine THA. Clinical Relevance— Bone infarction may be a predisposing factor for the development of osteosarcoma in the femora of dogs with THAs.}, number={1}, journal={VETERINARY SURGERY}, author={Marcellin-Little, DJ and DeYoung, DJ and Thrall, DE and Merrill, CL}, year={1999}, pages={54–60} }
 @article{marcellin-little_ferretti_roe_deyoung_1998, title={Hinged ilizarov external fixation for correction of antebrachial deformities}, volume={27}, ISSN={["1532-950X"]}, DOI={10.1111/j.1532-950X.1998.tb00122.x}, abstractNote={Objective —To evaluate hinged circular external fixation for correction of antebrachial deformities in dogs. Study Design —Uncontrolled clinical trial. Animal Population —Seven client‐owned dogs. Methods —Six dogs had one radius corrected and one dog had both radii corrected. Preoperative planning included measurement of the craniocaudal and mediolateral angular deformities, rotational deformity, length deficit, origin of deformity, graphical or mathematical determination of the amplitude and direction of the actual limb deformity, and frame assembly. Results —Preoperatively, function and cosmesis were assessed to be fair to poor in all dogs. Deformity correction started 48 to 60 hours postoperatively and ranged from 0.46 mm to 1.36 mm twice daily. Hospitalization time ranged from 4 to 6 days. Corrections were mostly made by the owners, at home. Lengthening and angular correction ranged from 3 to 38 mm and 18° to 48°. Mean residual deformities were 2.7% of radial length and 2.7°. The time duration with the circular external fixators in place ranged from 29 to 71 days. Two additional surgeries were necessary in one dog because of wire breakage. Mean follow‐up was 40 months. Long‐term function and cosmesis were good to excellent in all dogs. Conclusion—Although complications were present in six of seven dogs, the outcome of hinged Ilizarov external fixation was successful in all dogs treated for deformities of the antebrachium. Clinical Relevance —Despite complex preoperative planning, the placement of hinged circular external fixators is straightforward, and allows precise correction of complex antebrachial deformities with minimal tissue trauma.}, number={3}, journal={VETERINARY SURGERY}, author={Marcellin-Little, DJ and Ferretti, A and Roe, SC and DeYoung, DJ}, year={1998}, pages={231–245} }
 @article{massat_miller_deyoung_schiller_aberman_deyoung_1998, title={Single-stage revision using an uncemented, porous-coated, anatomic endoprosthesis in two dogs: Case report}, volume={27}, ISSN={["1532-950X"]}, DOI={10.1111/j.1532-950X.1998.tb00125.x}, abstractNote={Objective —To describe the clinical and radiographic features of septic and aseptic failure of two femoral endoprostheses and their successful revision. Study Design —Case report. Animals or Sample Population—Two skeletally mature male research dogs. Methods —An uncemented porous‐coated anatomic (PCA) endoprosthesis was implanted in a single‐stage revision procedure after thorough debridement and lavage of the femoral canal. An autogenous cancellous bone graft was used in dog 2 (aseptic loosening). Serial clinical and radiographic examinations were performed postoperatively. The dogs were euthanatized 1 year (dog 1) and 2 years (dog 2) after revision surgery, and necropsy was performed. High‐resolution contact radiographs and histopathologic evaluation of femoral sections were obtained. Results —The cause of implant failure was septic loosening in dog 1 and aseptic loosening in dog 2. In both dogs, clinical function returned to normal after revision. Serial radiographic assessment after revision documented disappearance of the bone pedestal and the periprosthetic lucency. Cancellous hypertrophy seen adjacent to the proximal porous‐coated region of the implants provided radiographic evidence of bony fixation. Histological evaluation of femoral sections documented successful implant integration with bone and fibrous tissue. Conclusion—Revision with an uncemented implant in a single‐stage procedure was successful in the two dogs described in this report. Clinical Relevance —This report provides a detailed description of the clinical course and serial radiographic assessment of septic and aseptic loosening of two femoral endoprostheses. Single‐stage revision is a potential treatment for either condition as demonstrated by the successful outcome in these two dogs.}, number={3}, journal={VETERINARY SURGERY}, author={Massat, BJ and Miller, RT and DeYoung, BA and Schiller, RA and Aberman, HM and DeYoung, DJ}, year={1998}, pages={268–277} }
 @article{wylie_deyoung_drost_deyoung_1997, title={The effect of surgical approach on femoral stem position in canine cemented total hip replacement}, volume={26}, ISSN={["0161-3499"]}, DOI={10.1111/j.1532-950X.1997.tb01464.x}, abstractNote={A prospective clinical study was designed to determine the effect of surgical approach on femoral stem position in canine cemented total hip replacement. Candidates for total hip replacement were randomly placed into one of two groups. In one group (n = 10), a craniolateral approach to the hip joint was made, incorporating a femoral trochanteric osteotomy. In the other group (n = 11), a craniolateral approach to the hip joint was made without performing a femoral trochanteric osteotomy. Radiographs obtained immediately after the operation were evaluated by two independent examiners for femoral stem position (neutral, varus, or valgus) and percentage of femoral canal fill, using a defined protocol. There was no statistical difference in femoral stem position between the study groups, whereas a greater percentage of canal fill was associated with the neutral femoral stem position.}, number={1}, journal={VETERINARY SURGERY}, author={Wylie, KB and DeYoung, DJ and Drost, WT and DeYoung, BA}, year={1997}, pages={62–66} }
 @article{marcellin-little_papich_richardson_de young_1996, title={A model for pharmacokinetic distribution of cefazolin during total hip replacement}, volume={57}, journal={American Journal of Veterinary Research}, author={Marcellin-Little, D. J. and Papich, M. G. and Richardson, D. C. and De Young, D. J.}, year={1996}, pages={720–723} }
 @article{marcellinlittle_deyoung_ferris_berry_1994, title={INCOMPLETE OSSIFICATION OF THE HUMERAL CONDYLE IN SPANIELS}, volume={23}, ISSN={["0161-3499"]}, DOI={10.1111/j.1532-950X.1994.tb00509.x}, abstractNote={An evaluation of 157 dogs with humeral fractures was performed. Cocker spaniels were more likely to have humeral condylar fractures (HCFs) than other breeds (P < .001). Male cocker spaniels were at increased risk (P < .001). Cocker spaniels had more bilateral HCFs than other breeds of dogs (P < .001). Eighteen dogs (17 purebred spaniels and 1 crossbred spaniel) with HCFs of unknown cause or occurring with normal activity were further studied, using radiography of their humeral condyle bilaterally (n = 18), computed tomography (n = 3), biopsy (n = 2), bone scintigraphy (n = 2), and genetic evaluation (n = 8). Fourteen of these 18 dogs had a nonfractured contralateral condyle. Twelve (86%) of the 14 nonfractured humeral condyles had a radiolucent line within the center of the condyle, 13 (93%) had radiographic signs of degenerative joint disease and an abnormal medial coronoid process, and six (43%) had periosteal proliferation involving the lateral epicondyle. Examination of biopsy samples from the fracture sites of two cocker spaniels showed fibrous tissue present at the fracture surfaces. The results of this study suggest an association between incomplete ossification of the humeral condyle in cocker spaniels and Brittany spaniels and a high prevalence of HCFs. Eight affected cocker spaniels with available pedigree information were found to be genetically related, suggesting that incomplete ossification of the humeral condyle may be a genetic disease with a recessive mode of inheritance.}, number={6}, journal={VETERINARY SURGERY}, author={MARCELLINLITTLE, DJ and DEYOUNG, DJ and FERRIS, KK and BERRY, CM}, year={1994}, pages={475–477} }
 @article{deyoung_schiller_deyoung_1993, title={RADIOGRAPHIC ASSESSMENT OF A CANINE UNCEMENTED POROUS-COATED ANATOMIC TOTAL HIP-PROSTHESIS}, volume={22}, ISSN={["0161-3499"]}, DOI={10.1111/j.1532-950X.1993.tb00424.x}, abstractNote={Thirty uncemented porous‐coated anatomic total hip prostheses in 24 dogs were evaluated radiographically at 6 months, 12 months, or 18 months after arthroplasty. All dogs were fully weight bearing and free of lameness at the time of follow‐up. Radiographs were assessed for prosthetic component alignment, percentage of femoral canal fill, resorptive and formative bony changes, and changes at the implant bone interface. No evidence of infection, loosening, or failure of component fixation was seen. Settling of the acetabular component and subsidence of the femoral stem was seen early after surgery. Cortical atrophy was seen in all femurs and was the most significant bony remodeling change. Early results of clinical and radiographic evaluation of uncemented total hip arthroplasty in dogs have been encouraging.}, number={6}, journal={VETERINARY SURGERY}, author={DEYOUNG, DJ and SCHILLER, RA and DEYOUNG, BA}, year={1993}, pages={473–481} }
 @article{deyoung_deyoung_aberman_kenna_hungerford_1992, title={IMPLANTATION OF AN UNCEMENTED TOTAL HIP-PROSTHESIS - TECHNIQUE AND INITIAL RESULTS OF 100 ARTHROPLASTIES}, volume={21}, ISSN={["0161-3499"]}, DOI={10.1111/j.1532-950X.1992.tb00041.x}, abstractNote={A porous‐coated modular total hip system was developed for uncemented implantation in dogs. The operative technique was developed in cadaver bones and live animals. One hundred uncemented total hip arthroplasties were performed in 92 dogs. Results were successful in 98% of the joints during follow‐ups of 3 months or more. Complications included three luxations of the prosthetic joint, two fissure fractures of the femoral cortex, and one complete displacement of the acetabular component from its bony bed. Four complications were resolved successfully.}, number={3}, journal={VETERINARY SURGERY}, author={DEYOUNG, DJ and DEYOUNG, BA and ABERMAN, HA and KENNA, RV and HUNGERFORD, DS}, year={1992}, pages={168–177} }
 @article{deyoung_schiller_1992, title={RADIOGRAPHIC CRITERIA FOR EVALUATION OF UNCEMENTED TOTAL HIP-REPLACEMENT IN DOGS}, volume={21}, ISSN={["0161-3499"]}, DOI={10.1111/j.1532-950X.1992.tb00021.x}, abstractNote={A zonal analysis system and corresponding nomenclature were developed to describe the location and nature of radiographic changes in canine uncemented total hip arthroplasties. Criteria to assess prosthetic component alignment, percentage of femoral canal fill, resorptive and formative bony changes, and alterations in the bone at the implant‐bone interface were derived by studying serial radiographs of 100 consecutive canine uncemented total hip arthroplasties for up to 30 months after surgery.}, number={2}, journal={VETERINARY SURGERY}, author={DEYOUNG, DJ and SCHILLER, RA}, year={1992}, pages={88–98} }
 @article{marcellin-little_deyoung_doyens_deyoung, title={Canine uncemented porous-coated anatomic total hip arthroplasty: Results of a long-term prospective evaluation of 50 consecutive cases}, volume={10}, ISBN={1018-2357}, number={1}, journal={European Journal of Companion Animal Practice}, author={Marcellin-Little, D. J. and DeYoung, B. A. and Doyens, H. and DeYoung, D. J.}, pages={49} }