@article{schulman_roccabianca_avallone_bertram_chalkley_chambers_donovan_foster_meuten_porcellato_et al._2022, title={Reporting guidelines for manuscripts on tumor prognosis}, ISSN={["1544-2217"]}, DOI={10.1177/03009858221082207}, abstractNote={Keywords neoplasia, observational study design, oncology, pathology, prognostic markers, reporting guidelines, scientific publishing, surgical pathology, veterinary}, journal={VETERINARY PATHOLOGY}, author={Schulman, F. Yvonne and Roccabianca, Paola and Avallone, Giancarlo and Bertram, Christof A. and Chalkley, Mark and Chambers, James K. and Donovan, Taryn A. and Foster, Robert A. and Meuten, Donald and Porcellato, Ilaria and et al.}, year={2022}, month={Feb} }
 @article{bertram_aubreville_donovan_bartel_wilm_marzahl_assenmacher_becker_bennett_corner_et al._2021, title={Computer-assisted mitotic count using a deep learning-based algorithm improves interobserver reproducibility and accuracy}, ISSN={["1544-2217"]}, DOI={10.1177/03009858211067478}, abstractNote={The mitotic count (MC) is an important histological parameter for prognostication of malignant neoplasms. However, it has inter- and intraobserver discrepancies due to difficulties in selecting the region of interest (MC-ROI) and in identifying or classifying mitotic figures (MFs). Recent progress in the field of artificial intelligence has allowed the development of high-performance algorithms that may improve standardization of the MC. As algorithmic predictions are not flawless, computer-assisted review by pathologists may ensure reliability. In the present study, we compared partial (MC-ROI preselection) and full (additional visualization of MF candidates and display of algorithmic confidence values) computer-assisted MC analysis to the routine (unaided) MC analysis by 23 pathologists for whole-slide images of 50 canine cutaneous mast cell tumors (ccMCTs). Algorithmic predictions aimed to assist pathologists in detecting mitotic hotspot locations, reducing omission of MFs, and improving classification against imposters. The interobserver consistency for the MC significantly increased with computer assistance (interobserver correlation coefficient, ICC = 0.92) compared to the unaided approach (ICC = 0.70). Classification into prognostic stratifications had a higher accuracy with computer assistance. The algorithmically preselected hotspot MC-ROIs had a consistently higher MCs than the manually selected MC-ROIs. Compared to a ground truth (developed with immunohistochemistry for phosphohistone H3), pathologist performance in detecting individual MF was augmented when using computer assistance (F1-score of 0.68 increased to 0.79) with a reduction in false negatives by 38%. The results of this study demonstrate that computer assistance may lead to more reproducible and accurate MCs in ccMCTs.}, journal={VETERINARY PATHOLOGY}, author={Bertram, Christof A. and Aubreville, Marc and Donovan, Taryn A. and Bartel, Alexander and Wilm, Frauke and Marzahl, Christian and Assenmacher, Charles-Antoine and Becker, Kathrin and Bennett, Mark and Corner, Sarah and et al.}, year={2021}, month={Dec} }
 @article{meuten_moore_donovan_bertram_klopfleisch_foster_smedley_dark_milovancev_stromberg_et al._2021, title={International Guidelines for Veterinary Tumor Pathology: A Call to Action}, ISSN={["1544-2217"]}, DOI={10.1177/03009858211013712}, abstractNote={Standardization of tumor assessment lays the foundation for validation of grading systems, permits reproducibility of oncologic studies among investigators, and increases confidence in the significance of study results. Currently, there is minimal methodological standardization for assessing tumors in veterinary medicine, with few attempts to validate published protocols and grading schemes. The current article attempts to address these shortcomings by providing standard guidelines for tumor assessment parameters and protocols for evaluating specific tumor types. More detailed information is available in the Supplemental Files, the intention of which is 2-fold: publication as part of this commentary, but more importantly, these will be available as "living documents" on a website (www.vetcancerprotocols.org), which will be updated as new information is presented in the peer-reviewed literature. Our hope is that veterinary pathologists will agree that this initiative is needed, and will contribute to and utilize this information for routine diagnostic work and oncologic studies. Journal editors and reviewers can utilize checklists to ensure publications include sufficient detail and standardized methods of tumor assessment. To maintain the relevance of the guidelines and protocols, it is critical that the information is periodically updated and revised as new studies are published and validated with the intent of providing a repository of this information. Our hope is that this initiative (a continuation of efforts published in this journal in 2011) will facilitate collaboration and reproducibility between pathologists and institutions, increase case numbers, and strengthen clinical research findings, thus ensuring continued progress in veterinary oncologic pathology and improving patient care.}, journal={VETERINARY PATHOLOGY}, author={Meuten, Donald J. and Moore, Frances M. and Donovan, Taryn A. and Bertram, Christof A. and Klopfleisch, Robert and Foster, Robert A. and Smedley, Rebecca C. and Dark, Michael J. and Milovancev, Milan and Stromberg, Paul and et al.}, year={2021}, month={Jul} }
 @article{donovan_moore_bertram_luong_bolfa_klopfleisch_tvedten_salas_whitley_aubreville_et al._2021, title={Mitotic Figures-Normal, Atypical, and Imposters: A Guide to Identification}, volume={58}, ISSN={["1544-2217"]}, DOI={10.1177/0300985820980049}, abstractNote={Counting mitotic figures (MF) in hematoxylin and eosin-stained histologic sections is an integral part of the diagnostic pathologist's tumor evaluation. The mitotic count (MC) is used alone or as part of a grading scheme for assessment of prognosis and clinical decisions. Determining MCs is subjective, somewhat laborious, and has interobserver variation. Proposals for standardizing this parameter in the veterinary field are limited to terminology (use of the term MC) and area (MC is counted in an area measuring 2.37 mm2). Digital imaging techniques are now commonplace and widely used among veterinary pathologists, and field of view area can be easily calculated with digital imaging software. In addition to standardizing the methods of counting MF, the morphologic characteristics of MF and distinguishing atypical mitotic figures (AMF) versus mitotic-like figures (MLF) need to be defined. This article provides morphologic criteria for MF identification and for distinguishing normal phases of MF from AMF and MLF. Pertinent features of digital microscopy and application of computational pathology (CPATH) methods are discussed. Correct identification of MF will improve MC consistency, reproducibility, and accuracy obtained from manual (glass slide or whole-slide imaging) and CPATH approaches.}, number={2}, journal={VETERINARY PATHOLOGY}, author={Donovan, Taryn A. and Moore, Frances M. and Bertram, Christof A. and Luong, Richard and Bolfa, Pompei and Klopfleisch, Robert and Tvedten, Harold and Salas, Elisa N. and Whitley, Derick B. and Aubreville, Marc and et al.}, year={2021}, month={Mar}, pages={243–257} }
 @article{meuten_munday_hauck_2018, title={Time to Standardize? Time to Validate?}, volume={55}, ISSN={["1544-2217"]}, DOI={10.1177/0300985817753869}, number={2}, journal={VETERINARY PATHOLOGY}, author={Meuten, Don and Munday, John S. and Hauck, Marlene}, year={2018}, month={Mar}, pages={195–199} }
 @article{meuten_moore_george_2016, title={Mitotic Count and the Field of View Area: Time to Standardize}, volume={53}, ISSN={["1544-2217"]}, DOI={10.1177/0300985815593349}, number={1}, journal={VETERINARY PATHOLOGY}, author={Meuten, D. J. and Moore, F. M. and George, J. W.}, year={2016}, month={Jan}, pages={7–9} }
 @article{freire_meuten_lascelles_2014, title={Pathology of Articular Cartilage and Synovial Membrane From Elbow Joints With and Without Degenerative Joint Disease in Domestic Cats}, volume={51}, ISSN={["1544-2217"]}, url={https://dx.doi.org/10.1177/0300985813516648}, DOI={10.1177/0300985813516648}, abstractNote={The elbow joint is one of the feline appendicular joints most commonly and severely affected by degenerative joint disease. The macroscopic and histopathological lesions of the elbow joints of 30 adult cats were evaluated immediately after euthanasia. Macroscopic evidence of degenerative joint disease was found in 22 of 30 cats (39 elbow joints) (73.33% cats; 65% elbow joints), and macroscopic cartilage erosion ranged from mild fibrillation to complete ulceration of the hyaline cartilage with exposure of the subchondral bone. Distribution of the lesions in the cartilage indicated the presence of medial compartment joint disease (most severe lesions located in the medial coronoid process of the ulna and medial humeral epicondyle). Synovitis scores were mild overall and correlated only weakly with macroscopic cartilage damage. Intra-articular osteochondral fragments either free or attached to the synovium were found in 10 joints. Macroscopic or histologic evidence of a fragmented coronoid process was not found even in those cases with intra-articular osteochondral fragments. Lesions observed in these animals are most consistent with synovial osteochondromatosis secondary to degenerative joint disease. The pathogenesis for the medial compartmentalization of these lesions has not been established, but a fragmented medial coronoid process or osteochondritis dissecans does not appear to play a role.}, number={5}, journal={VETERINARY PATHOLOGY}, publisher={SAGE Publications Sage CA: Los Angeles, CA}, author={Freire, M. and Meuten, D. and Lascelles, D.}, year={2014}, month={Sep}, pages={968–978} }
 @article{simpson_bastian_michael_webster_prasad_conway_prieto_gary_goldschmidt_esplin_et al._2014, title={Sporadic naturally occurring melanoma in dogs as a preclinical model for human melanoma}, volume={27}, ISSN={["1755-148X"]}, DOI={10.1111/pcmr.12185}, abstractNote={Melanoma represents a significant malignancy in humans and dogs. Different from genetically engineered models, sporadic canine melanocytic neoplasms share several characteristics with human disease that could make dogs a more relevant preclinical model. Canine melanomas rarely arise in sun-exposed sites. Most occur in the oral cavity, with a subset having intra-epithelial malignant melanocytes mimicking the in situ component of human mucosal melanoma. The spectrum of canine melanocytic neoplasia includes benign lesions with some analogy to nevi, as well as invasive primary melanoma, and widespread metastasis. Growing evidence of distinct subtypes in humans, differing in somatic and predisposing germ-line genetic alterations, cell of origin, epidemiology, relationship to ultraviolet radiation and progression from benign to malignant tumors, may also exist in dogs. Canine and human mucosal melanomas appear to harbor BRAF, NRAS, and c-kit mutations uncommonly, compared with human cutaneous melanomas, although both species share AKT and MAPK signaling activation. We conclude that there is significant overlap in the clinical and histopathological features of canine and human mucosal melanomas. This represents opportunity to explore canine oral cavity melanoma as a preclinical model.}, number={1}, journal={PIGMENT CELL & MELANOMA RESEARCH}, author={Simpson, R. Mark and Bastian, Boris C. and Michael, Helen T. and Webster, Joshua D. and Prasad, Manju L. and Conway, Catherine M. and Prieto, Victor M. and Gary, Joy M. and Goldschmidt, Michael H. and Esplin, D. Glen and et al.}, year={2014}, month={Jan} }
 @misc{meuten_law_stromberg_cullen_2013, title={From Bipeds to an Honorary Member of the American College of Veterinary Pathologists}, volume={50}, ISSN={["1544-2217"]}, DOI={10.1177/0300985813480219}, number={3}, journal={VETERINARY PATHOLOGY}, author={Meuten, D. J. and Law, J. M. and Stromberg, P. C. and Cullen, J. M.}, year={2013}, month={May}, pages={365–365} }
 @article{law_stromberg_meuten_cullen_2011, title={Necropsy or Autopsy? It’s All About Communication!}, volume={49}, ISSN={0300-9858 1544-2217}, url={http://dx.doi.org/10.1177/0300985811410722}, DOI={10.1177/0300985811410722}, abstractNote={Several of us have decided that communication is more important than tradition. Yes, Virginia, we were all drilled in the discipline of veterinary pathology by traditionalists. We’re stubborn individualists, aren’t we? Greats like John King have necropsied thousands of animals, and we want our procedure to be distinguished from the ‘‘other’’ side—the RDs (well okay, the MDs). The short answer is that ‘‘necropsy’’ literally means ‘‘death examination’’ or examination of death and finds its application in the study of bodies following death. The term is general without reference to species. ‘‘Autopsy’’ literally means ‘‘self-examination,’’ and some of us were taught that the frame of reference for ‘‘self’’ referred to the postmortem examination of ‘‘ourselves’’ or our own species, humans. As such, postmortem examination of nonhumans was proscribed from using the term and was designated ‘‘necropsy.’’ But hold on there a minute, let’s see what Webster has to say. Or as Don Meuten likes to say, ‘‘Show me the reference!’’}, number={2}, journal={Veterinary Pathology}, publisher={SAGE Publications}, author={Law, M. and Stromberg, P. and Meuten, D. and Cullen, J.}, year={2011}, month={Jun}, pages={271–272} }
 @article{ranck_linder_haber_meuten_2008, title={Primary intimal aortic angiosarcoma in a dog}, volume={45}, ISSN={["0300-9858"]}, DOI={10.1354/vp.45-3-361}, abstractNote={A primary intimal aortic angiosarcoma was diagnosed in a 4-year-old, spayed female German Shepherd that presented for complications of thromboembolic disease because of infarcts in multiple organs. On gross examination, aneurysmal dilatation of the aorta was associated with a friable, necrotic mass attached to the endothelial surface, which partially occluded the aortic lumen. On histologic examination, plump neoplastic spindle cells formed a plaque-like mass arising from the intima that merged with a large accumulation of fibrin and necrotic debris, and projected into the lumen. Neoplastic cells invaded periaortic vessels and were seen in some infarct-associated thromboemboli. Tumor cells expressed vimentin and CD31, with infrequent, patchy staining with factor VIII-related antigen; tumor cells were negative for cytokeratin and smooth-muscle actin. Aortic angiosarcoma is a rare malignancy in humans. This is the first description of a primary intimal aortic angiosarcoma in a dog, with immunohistochemical evidence of endothelial origin.}, number={3}, journal={VETERINARY PATHOLOGY}, author={Ranck, R. S. and Linder, K. E. and Haber, M. D. and Meuten, D. J.}, year={2008}, month={May}, pages={361–364} }
 @article{meuten_rebar_1998, title={A patient with clinical chemistry abnormalities}, volume={12}, number={1998}, journal={North American Veterinary Conference. Veterinary Proceedings}, author={Meuten, D. J. and Rebar, A.}, year={1998}, pages={114} }
 @article{meuten_rebar_1998, title={Clinical endocrinology}, volume={12}, number={1998}, journal={North American Veterinary Conference. Veterinary Proceedings}, author={Meuten, D. J. and Rebar, A.}, year={1998}, pages={117–118} }
 @article{meuten_rebar_1998, title={Cytologic diagnosis of soft tissue and lymph node abnormalities}, volume={12}, number={1998}, journal={North American Veterinary Conference. Veterinary Proceedings}, author={Meuten, D. J. and Rebar, A.}, year={1998}, pages={109–111} }
 @article{meuten_rebar_1998, title={Cytopathology of skin and subcutaneous masses}, volume={12}, number={1998}, journal={North American Veterinary Conference. Veterinary Proceedings}, author={Meuten, D. J. and Rebar, A.}, year={1998}, pages={112–113} }
 @article{meuten_rebar_1998, title={Examples of abnormalities in body effusions and clinical chemistry}, volume={12}, number={1998}, journal={North American Veterinary Conference. Veterinary Proceedings}, author={Meuten, D. J. and Rebar, A.}, year={1998}, pages={115–116} }
 @article{meuten_1998, title={Use of cytology to establish a diagnosis}, volume={12}, number={1998}, journal={North American Veterinary Conference. Veterinary Proceedings}, author={Meuten, D. J.}, year={1998}, pages={107–109} }
 @article{hawkins_davidson_meuten_rottman_al._1997, title={Cytologic identification of Toxoplasma gondii in bronchoalveolar lavage fluid of experimentally infected cats}, volume={210}, number={5}, journal={Journal of the American Veterinary Medical Association}, author={Hawkins, E. C. and Davidson, M. G. and Meuten, D. J. and Rottman, J. B. and al.}, year={1997}, pages={648–650} }
 @article{breitschwerdt_geoly_meuten_levine_howard_hegarty_stafford_1996, title={Myocarditis in mice and guinea pigs experimentally infected with a canine-origin Borrelia isolate from Florida}, volume={57}, number={4}, journal={American Journal of Veterinary Research}, author={Breitschwerdt, E. B. and Geoly, F. J. and Meuten, D. J. and Levine, J. F. and Howard, P. and Hegarty, B. C. and Stafford, L. C.}, year={1996}, pages={505–511} }
 @article{breitschwerdt_nicholson_kiehl_steers_meuten_levine_1994, title={Natural infections with Borrelia spirochetes in two dogs from Florida}, volume={32}, number={2}, journal={Journal of Clinical Microbiology}, author={Breitschwerdt, E. B. and Nicholson, W. L. and Kiehl, A. R. and Steers, C. and Meuten, D. J. and Levine, J. F.}, year={1994}, pages={352–357} }