Deanna J Nelson

Physiological Calcium Phosphate Management in Two Biofluids

Combinations of carnosine and zinc for the treatment and prevention of viral infections

(Patent No. WO2022005848A1).

Ramatroban for chemoprophylaxis and treatment of COVID-19: David takes on Goliath

Chiang, K. C., Rizk, J. G., Nelson, D. J., Krishnamurti, L., Subbian, S., Imig, J. D., … Gupta, A. (2022, February 24). EXPERT OPINION ON THERAPEUTIC TARGETS, Vol. 2.

Magnesium biotinate compositions and methods of use

(U.S. Patent Pending No. US20180071264A1).

Pharmaceutical quality strontium L-lactate. U.S

(Patent No. US11026906B2).

Drug delivery via ferric citrate

[U.S. Patent Pending].

Liquid concentrate of calcium and magnesium

(Patent No. WO2020210608A1).

Pharmaceutical quality strontium L-lactate

(Republic of South Africa Patent No. 2019/02258).

Pharmaceutical quality strontium L-lactate

(Patent No. US10463636B2).

Magnesium biotinate compositions and methods of use

(U.S. Patent No. 20180071264).

Magnesium picolinate compositions and methods of use

(US Patent No. US20180098976).

Phosphorus binder composition for treatment of hyperphosphatemia

(U.S. Patent No. US8759398B2).

Blood Substitutes: Hemoglobin-Based Oxygen Carriers

In J. Swarbrick (Ed.), Encyclopedia of Pharmaceutical Science and Technology, Fourth Edition (4th ed., pp. 330–341).

Combined calcium, magnesium, and Vitamin D supplements

(U.S. Patent No. 8324191).

Iron preparation suitable for pharmaceutical formulation and process for the preparation thereof

(U.S. Patent No. US8178709B2).

Phosphate Binder Comparison: Sevelamer Carbonate & CaSuccinate/MgLipoate

Nelson, D. J., Holberg, W. C., Hruska, K. A., & Fang, Y. (2012, November). Phosphate Binder Comparison: Sevelamer Carbonate & CaSuccinate/MgLipoate. Presented at the American Society of Nephrology 2012 National Meeting (Kidney Week 2012), San Diego, CA.

Phosphorus binder for treatment of kidney disease

(U.S. Patent No. 8034833).

Phosphorus binder for treatment of kidney disease

(U.S. Patent No. 7862836).

Stable, water-insoluble R-(+)-alpha-lipoic acid salt useful for the treatment of diabetes mellitus and its co-morbidities

(U.S. Patent No. 8222432).

Comparing Soluble Ferric Pyrophosphate to Common Iron Salts and Chelates as Sources of Bioavailable Iron in a Caco-2 Cell Culture Model

Journal of Agricultural and Food Chemistry, 57(11), 5014–5019.

Non-hygroscopic L-carnitine salts

(U.S. Patent No. 7572832).

Methods for the preparation and formulation and use of lithium valproate

(U.S. Patent No. 7790921).

Methods for the preparation and formulation and use of lithium valproate

(U.S. Patent No. 7449598).

Methods for the preparation and formulation of L-carnitine valproate salts

(U.S. Patent No. 7456216).

Synthesis of hydrazine and chlorinated derivatives of bicyclic pyridazines

(U.S. Patent No. 7220858).

Uptake and reduction of α-lipoic acid by human erythrocytes

Clinical Biochemistry, 40(15), 1135–1142.

Cellular disulfide-reducing capacity: An integrated measure of cell redox capacity

Biochemical and Biophysical Research Communications, 344(4), 1352–1359.

DCLHb and rHb1.1

In Blood Substitutes (pp. 399–414).

Stability of parenteral nutrition admixtures admixed with a novel parenteral iron dosage form

Presented at the National Meeting, Society for Free Radical Biology & Medicine, Denver, CO.

Methods for the preparation and formulation of magnesium valproate hydrate

(U.S. Patent No. 7482486).

Effective attenuation of endotoxin-induced acute lung injury by 2,3-diacetyloxybenzoic acid in two independent animal models

Pulmonary Pharmacology & Therapeutics, 17(2), 105–110.

Oligo(ethylene glycol)-terminated 1,2-dithiolanes and their conjugates useful for preparing self-assembled monolayers

(U.S. Patent No. 6756354).

Oxygen Carriers as Alternatives to Red Blood Cell Transfusions

Nelson, D. J. (2004, May 1). Presented at the Annual Meeting, Infusion Nurses Society, Salt Lake City, UT.

Aminosalicylate derivatives for treatment of inflammatory bowel disease

(U.S. Patent No. 7157444).

Stable hydralazine pharmaceutical compositions

(U.S. Patent Application No. 7989452).

Blood substitutes: Hemoglobin-based oxygen carriers

In J. Swarbrick & J. C. Boylan (Eds.), Encyclopedia of Pharmaceutical Technology (Vol. 20, pp. 236–262). New York: Marcel Dekker, Inc.

Biocompatible surfaces and a method for their preparation

(U.S. Patent No. US6204254B1).

Blood substitutes: Hemoglobin-based oxygen carriers

In J. Swarbrick & J. C. Boylan (Eds.), Encyclopedia of Pharmaceutical Technology (Vol. 19, pp. 1–33). New York: Marcel Dekker, Inc.

Reagents for isotropic size enhancement of a peptide, protein, nucleotide or other substrate

(U.S. Patent No. 6018035).

Surface Modification of Diaspirin Cross-linked Hemoglobin (DCLHb) with Chondroitin-4-sulfate Derivatives. Part 1

Bioconjugate Chemistry, 11(5), 705–713.

Covalently modified hemoglobin composition having low temperature-dependent oxygen-binding function

(U.S. Patent Application No. 6180598).

Polymerization of Diaspirin Cross-Linked Hemoglobin (DCLHb) with Water-Soluble, Nonimmunogenic Polyamide Cross-Linking Agents

Bioconjugate Chemistry, 10(6), 1013–1020.

Polymerization of diaspirin crosslinked hemoglobin (DCLHb) with PEG activated with benzenesulfonate bearing electron-withdrawing groups

Tetrahedron, 55(8), 2147–2156.

Therapeutic hemoglobin composition having isotropically increased size

(U.S. Patent No. 5981710).

A Convenient Large Scale Synthesis of N, N'-Disuccinimidyl Carbonate

Synthetic Communications, 28(21), 4019–4024.

Absence of Immunogenicity of Diaspirin Cross-Linked Hemoglobin in Humans

Blood, 91(2), 710–716.

Hemoglobin Therapeutics: Current status and clinical trials

Nelson, D. J. (1998, March 18). Presented at the Annual Meeting, Southeastern Area Blood Bankers, Atlanta, GA.

Synthesis of Water-Soluble, Nonimmunogenic Polyamide Cross-Linking Agents†

Bioconjugate Chemistry, 9(6), 645–654.

*HemAssist™: Development and Clinical Profile

In A. S. Rudolph, R. Rabinovici, & G. Z. Feuerstein (Eds.), Red Blood Cell Substitutes (pp. 365–412).

Blood and HemAssist (DCLHb): Potentially a Complementary Therapeutic Team

In T. M. S. Chang (Ed.), Blood Substitutes: Principles, Methods, Products and Clinical Trials (pp. 36–91). New York: Karger Landes Systems.

DCLHb, a well-characterized hemoglobin

VII International Symposium on Blood Substitutes, Program and Abstracts, (P08-b), 101.

Progress in developing therapeutic blood substitutes. Chicago Section of the American Chemical Society

Chemical Bulletin, 1–2.

Stabilization of therapeutic hemoglobin compositions

(Patent No. WO1997039027A1).

Cyclizations during the Grignard reactions of omega-bromoalkynes

Croatica Chimica Acta, 69(4), 1473–1490.

Diaspirin Crosslinked Hemoglobin (DCLHb): Biocompatibility Studies

Presented at the American Association of Pharmaceutical Scientists.

Hemoglobin Based Blood Substitutes: New Biologics with Unique and Unexpected Pharmacologic Properties

Nelson, D. J. (1996, May 20). Presented at the American Association of Pharmaceutical Scientists Midwest Regional Meeting, Chicago, IL.

Method and composition for administration of beneficial agent by controlled dissolution

(U.S. Patent No. 5510115).

Modification of DCLHb with proprietary polyamides

Artif Cells Blood Subs Immob Biotech, 24(4), 347.

Use of 2,3-alkylcarbonyloxybenzoic acid in treating adult respiratory distress syndrome

(U.S. Patent No. 5502111).

Hemoglobin Based Blood Substitutes

Presented at the Annual Meeting of the Oxygen Society.

Diaspirin Crosslinked Hemoglobin (DCLHbTM): Bioanalytical Studies in Swine

Artificial Cells, Blood Substitutes, and Biotechnology, 22(3), 917–922.

Diaspirin Crosslinked Hemoglobin (DCLHbTM)Polymerization

Artificial Cells, Blood Substitutes, and Biotechnology, 22(3), 923–931.

Water-soluble nonimmunogenic polyamide crosslinking agents

(Patent No. WO1994012220A2).

Diaspirin Crosslinked Hemoglobin (DCLHbTM) Polymerization

Vth International Symposium on Blood Substitutes, Program and Abstracts, (H66).

Diaspirin Crosslinked Hemoglobin (DCLHb): Bioanalytical Studies in Swine

Vth International Symposium on Blood Substitutes, Program and Abstracts, (H36).

Glassy sugar matrix for administration of beneficial agent in blood preservation and drug delivery

(Patent No. EP0343239B1).

Interactions of Human Monocytes with Hemoglobins: In Vitro Assessment

Vth International Symposium on Blood Substitutes, Program and Abstracts, (H37).

Oxirane-modified hemoglobin based composition

(U.S. Patent No. US5248766A).

Diaspirin cross-linked hemoglobin: an investigational drug exemplifying hemoglobin-based blood substitutes

Nelson, D. J., Bush, S. L., Farmer, M. C., & Picken, J. (1992, December). Presented at the American Society of Hospital Pharmacists National Meeting, Orlando, FL.

New blood product: diaspirin cross-linked hemoglobin as a blood substitute, I: Characterization and oxygen transport.

Transfusion, 32(S8), S21.

New blood product: diaspirin cross-linked hemoglobin as a blood substitute, II: Storage stability

Transfusion, 32(8S), S22.

Non-immunogenic hemoglobin oligomer composition used as oxygen carrier, maintains normal oxygen tension in organs and tissues, is non-toxic or pyrogenic and free from contamination

(U.S. Patent Application No. WO9203-155-A).

Preparation and Characterization of Diaspirin Cross-Linked Hemoglobin Solutions for Preclinical Studies

Biomaterials, Artificial Cells and Immobilization Biotechnology, 20(2-4), 423–427.

Process for the Production of Crosslinked Hemoglobin in the Presence of Sodium Tripolyphosphate

(U.S. Patent No. 5128452).

Synthesis and Properties of Polymerized, Diaspirin Cross-Linked Hemoglobins

Biomaterials, Artificial Cells and Immobilization Biotechnology, 20(2-4), 253–258.

Diaspirin Crosslinked Hemoglobin (DCLHb): An Update

Presented at the Annual Scientific Meeting IX, British Blood Transfusion Society, Nottingham, England.

Immunological Implications of Protein Formulations

Presented at the American Association of Pharmaceutical Sciences Eastern Regional Meeting, New Brunswick, NJ.

Pharmaceutical Grade 3,5-Dibromosalicylic Acid

(U.S. Patent No. 5013866).

Preparation and characterization of diaspirin cross-linked hemoglobin solutions for preclinical studies

Biomaterials, Artificial Cells and Immobilization Biotechnology, 19(2), 452.

Preparation of Bis(Salicyl) Diesters

(U.S. Patent No. 5041615).

Synthesis and properties of polymerized, diaspirin cross-linked hemoglobins

Biomaterials, Artificial Cells and Immobilization Biotechnology, 19(2), 451.

Analytical Characterization of alpha,alpha-Crosslinked Hemoglobin

Presented at the 23rd Great Lakes Regional Meeting, American Chemical Society, DeKalb, IL.

Determination of the Percent cross-linking in Diaspirin Cross-lined Hemoglobin (DCLHb) using Size-exclusion Chromatography

Presented at the Annual Meeting, American Institute of Chemical Engineers, Chicago, IL.

Diaspirin Crosslinked Hemoglobin (DCLHb): Preparation and Properties

Presented at the 23rd Great Lakes Regional Meeting, American Chemical Society, DeKalb, IL.

Directing Intramolecular Crosslinking of Hemoglobin

Presented at the 23rd Great Lakes Regional Meeting, American Chemical Society, DeKalb, IL.

Novel aspects of diaspirin cross-linked hemoglobin synthesis and purification

Biomaterials, Artificial Cells and Artificial Organs, 17(5), 636.

The Use of 31P NMR in Determining the Enan¬tiomeric Purity of Lactic and Malic Acid Samples

Smith, W. J., Flavin, M., Nelson, D., Pereira, D., & Ziemnicka-Merchant, B. (1989, May 11). Presented at the Baxter Healthcare Corporation Parenterals R & D Symposium.

Cardiovascular Maintenance with Blood Substitutes

Presented at the Baxter Travenol Science and Technology Seminar, Laguna Niguel, CA.

Nutrient Monoesters

(U.S. Patents No. 4655057).

Nutrient Polyesters

(U.S. Patent No. 4701443).

The Reaction of D-Glucose With Substituted Anilines: Investigation by Carbon-13 NMR Spectroscopy

Journal of Carbohydrate Chemistry, 4(1), 91–97.

Maillard polymers derived from D-glucose, D-fructose, 5-(hydroxymethyl)-2-furaldehyde and glycine and methionine

Journal of Agricultural and Food Chemistry, 32(6), 1428–1432.

CIDNP/FTNMR as a mechanistic probe in the pulse radiolysis of aqueous acetone and acetaldehyde

The Journal of Physical Chemistry, 83(17), 2186–2195.

Carbon-13 CIDNP from reactions of some simple organic and inorganic radicals during pulse radiolysis

The Journal of Physical Chemistry, 83(26), 3444–3448.

Chemically induced magnetic polarization studies in radiation and photochemistry

Reviews of Chemical Intermediates, 3(1-2), 131–168.

Synthesis of aryl alkynes

Preprints, American Chemical Society Division of Petroleum Chemistry, 24(1), 240–242.

CIDNP in pulse radiolysis of aqueous dimethyl sulfoxide

The Journal of Physical Chemistry, 82(12), 1400–1403.

CIDNP in the radiolysis of aqueous methanol indication of methoxy radical involvement

Chemical Physics Letters, 55(2), 323–326.

Chemically induced dynamic electron polarization. Examples; of S-T±1 polarization

[Report]. Journal of Magnetic Resonance (1969), 30(2), 263–272.

Time-resolved electron paramagnetic resonance and flow-Fourier transform nuclear magnetic resonance study in radiation chemistry. An example of Overhauser CIDNP

Journal of the American Chemical Society, 100(16), 5244–5246.

Unstable intermediates. Part 179. Electron spin resonance studies of radicals formed in irradiated organic sulphides and disulphides

Journal of the Chemical Society, Perkin Transactions 2, (3), 225.

Chemically Induced Dynamic Electron Polarization (CIDEP) in Pulse Radiolysis Examples of S-T-1 Polarization

Presented at the 174th National Meeting of the American Chemical Society, Division of Physical Chemistry, Chicago, Illinois.

Chemically Induced Dynamic Nuclear Polarization in Pulse Radiolysis of Aqueous Solutions

Presented at the 174th National Meeting, The American Chemical Society, Division of Organic Chemistry, Chicago, Illinois.

Chemically induced dynamic electron polarization in pulse radiolysis. S-T.+-.1 polarization from hydrogen radical reactions

Journal of the American Chemical Society, 99(1), 289–290.

Chemically induced dynamic electron polarization. Pulse radiolysis of aqueous solutions of micelles

Chemical Physics Letters, 46(2), 346–348.

Electron addition to organic halides: an ESR study of PhC2I−

Chemical Physics Letters, 47(3), 436–439.

Modification of the Grignard reaction

Journal of Chemical Education, 54(10), 648.

Nuclear magnetic resonance in pulse radiolysis. 2. CIDNP in radiolysis of aqueous solutions

Journal of the American Chemical Society, 99(6), 1745–1752.

Synthesis of aryl alkynes. 1. 2-Ethyl-4-methoxyphenylacetylene

The Journal of Organic Chemistry, 42(20), 3308–3309.

Unstable intermediates. Part 169. Electron capture processes in organic phosphates: an electron spin resonance study

Journal of the Chemical Society, Perkin Transactions 2, (3), 286.

Unstable intermediates. Part 178. The structure of intermediates formed in the radiolysis of thiols

Journal of the Chemical Society, Perkin Transactions 2, (15), 2005.

An ESR Study of Radiation Damage in Organophosphates

Presented at the 8th Central Regional Meeting,The American Chemical Society, Division of Organic Chemistry.

Electron Capture by Phosphate Esters

Presented at the The Chemical Society, Spring Meeting.

Electron capture by pyrophosphate ions: an electron spin resonance study

International Journal for Radiation Physics and Chemistry, 7(4), 581–583.

On the conformation of β-bromo radicals

Tetrahedron Letters, 16(34), 2953–2954.

The detection of thiyl radicals by ESR spectroscopy

Chemical Physics Letters, 36(3), 340–341.

Unstable intermediates. Part CLIII. Electron spin resonance spectra and structure of dichlorophosphoranyl radicals

Journal of the Chemical Society, Dalton Transactions, (12), 1164.

A new synthesis of allene alcohols

Journal of the Chemical Society, Chemical Communications, 444.

Synthesis of a 5,6-dienol

Journal of the Chemical Society, Chemical Communications, (13), 444a.

Synthetic Route to Polycyclic Conjugated Systems Containing Fused Four-Membered Rings

Presented at the 159th National Meeting, The American Chemical Society, Division of Organic Chemistry.

Chemistry of sulfoacetic acid derivatives. II. Reactions of phenyl esters and anilides of sulfoacetic acid

The Journal of Organic Chemistry, 34(11), 3414–3420.

Cyclization of acetylenic alkyl radicals

Tetrahedron Letters, 10(21), 1653–1656.

Organolithium Cyclizations of Acetylene Derivatives

Crandall, J. K., & Nelson, D. J. (1969, January). Presented at the 158th National Meeting, The American Chemical Society, Division of Organic Chemistry.

The Chemistry of Sulfoacetic Acid Derivatives

Presented at the 156th National Meeting, The American Chemical Society.

The reaction of arynes with enamines: A new ring expansion leading to benzocycloheptenone

Tetrahedron Letters, 10(47), 4163–4168.

Allenes by lithium aluminum hydride reduction of propargyl derivatives

The Journal of Organic Chemistry, 33(9), 3655–3657.

An intramolecular alkylation route to cycloalkylacetylenes

Chemical Communications (London), (18), 1069.

Organometallic cyclization of acetylene derivatives

(Ph.D. Dissertation). Indiana University.

DCLHb, a hemoglobin-based oxygen carrier: manufacture and characterization for use in clinical studies

Nelson, D. J., Azari, M., Moore, E., Estep, T., Picken, J., & Rohn, K. VII International Symposium on Blood Substitutes, Program and Abstracts, (3B-04), 34.

Evaluation of the immunogenicity of diaspirin crosslinked hemoglobin (DCLHb)

Nelson, D., Webb, E., Shelbourn, T., Moore, E., Mattia-Goldberg, C., & Patel, M. VII International Symposium on Blood Substitutes, Program and Abstracts, (P09-b), 102.

Moisture Analysis in Pharmaceutical Products

Ryan, J. A., & Nelson, D. Presented at the Labcon Central, Rosemont, IL.

New Light on an old Reaction: An NMR Study of Glucose-Amine Adducts

Ryan, J. A., Lavin, M., & Nelson, D. J. 327.

Synthesis of Aryl Alkynes

Nelson, D. J. Presented at the Symposium on Synthesis and Reactions of Acetylenes, Division of Petroleum Chemistry, Inc., National Meeting of the American Chemical Society, Honolulu, Hawaii.

Variable Field CIDNP in Pulse Radiolysis

Nelson, D. J. Presented at the Conference on Chemically Induced Magnetic Polarization, Queen's University, Kingston, Ontario.

Variable Field CIDNP/Flow FTNMR in the Study of Pulse Radiolysis

Nelson, D. J. Presented at the Division of Physical Chemistry, National Meeting of the American Chemical Society, Honolulu, Hawaii.