Dustin James Wcisel

Works (13)

Updated: February 11th, 2025 05:02

2025 journal article

Investigating the Impact of Whole-Genome Duplication on Transposable Element Evolution in Teleost Fishes

GENOME BIOLOGY AND EVOLUTION, 17(1).

By: R. Mallik *, D. Wcisel n, T. Near *, J. Yoder n  & A. Dornburg*

Ed(s): A. Betancourt

author keywords: living fossil; teleost genome duplication; transposable elements; Actinopterygii; Teleostei
topics (OpenAlex): Chromosomal and Genetic Variations; Genomics and Phylogenetic Studies; Studies on Chitinases and Chitosanases
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 23, 2024

2023 article

A chromosome-level genome assembly of longnose gar, Lepisosteus osseus

Mallik, R., Carlson, K. B., Wcisel, D. J., Fisk, M., Yoder, J. A., & Dornburg, A. (2023, April 29). (N. Whiteman, Ed.). G3-GENES GENOMES GENETICS, Vol. 4.

By: R. Mallik *, K. Carlson n, D. Wcisel n, M. Fisk*, J. Yoder n  & A. Dornburg*

Ed(s): N. Whiteman

author keywords: teleost genome duplication; holostei; longnose gar; chromosome level assembly; living fossil; transposable elements
MeSH headings : Humans; Animals; Evolution, Molecular; Fishes / genetics; Genome; Chromosomes / genetics; Phylogeny
topics (OpenAlex): Genetic diversity and population structure; Genomics and Phylogenetic Studies; Identification and Quantification in Food
TL;DR: The first high quality reference genome assembly and annotation of the longnose gar (Lepisosteus osseus) is reported, highlighting the potential utility of holostean genomes for understanding the evolution of vertebrate repetitive elements and providing a critical reference for comparative genomic studies utilizing ray-finned fish models. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 12, 2023

2023 article

Ancient fish lineages illuminate toll-like receptor diversification in early vertebrate evolution

Carlson, K. B., Nguyen, C., Wcisel, D. J., Yoder, J. A., & Dornburg, A. (2023, August 9). IMMUNOGENETICS, Vol. 8.

By: K. Carlson n, C. Nguyen *, D. Wcisel n, J. Yoder n  & A. Dornburg*

author keywords: Vertebrate; TLR; Immunogenetics; Evolution; Actinopterygii; Polypterus senegalus
topics (OpenAlex): Immune Response and Inflammation; Aquaculture disease management and microbiota; Antimicrobial Peptides and Activities
TL;DR: This work investigates the diversification of vertebrate Toll-like receptors (TLRs), one of the most ancient and well conserved innate immune receptor families found across the Tree of Life, integrating genomic data that represent all major vertebrate lineages with new transcriptomic data from Polypteriformes, the earliest diverging ray-finned fish lineage. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 28, 2023

2022 article

A highly diverse set of novel immunoglobulin-like transcript (NILT) genes in zebrafish indicates a wide range of functions with complex relationships to mammalian receptors

Wcisel, D. J., Dornburg, A., McConnell, S. C., Hernandez, K. M., Andrade, J., Jong, J. L. O., … Yoder, J. A. (2022, July 23). IMMUNOGENETICS, Vol. 7.

By: D. Wcisel n, A. Dornburg*, S. McConnell *, K. Hernandez *, J. Andrade *, J. Jong *, G. Litman*, J. Yoder n 

author keywords: Innate immunity; Gene content variation; Alternative immune haplotypes; Gene family evolution; Mammalian CD300 (CMRF35); Mammalian NCR2 (NKp44)
MeSH headings : Animals; Zebrafish / genetics; Amino Acid Sequence; Receptors, Immunologic / genetics; Genome / genetics; Immunoglobulins / genetics; Phylogeny; Mammals / genetics
topics (OpenAlex): Aquaculture disease management and microbiota; Immune Cell Function and Interaction; Invertebrate Immune Response Mechanisms
TL;DR: A higher level of genetic complexity, interindividual variation, and sequence diversity for NILTs than previously described is revealed, suggesting that this gene family likely plays multiple roles in host immunity. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: July 23, 2022

2022 article

Transcriptome annotation reveals minimal immunogenetic diversity among Wyoming toads, Anaxyrus baxteri

Carlson, K. B., Wcisel, D. J., Ackerman, H. D., Romanet, J., Christiansen, E. F., Niemuth, J. N., … Yoder, J. A. (2022, April 28). CONSERVATION GENETICS, Vol. 4.

By: K. Carlson n, D. Wcisel n, H. Ackerman  n, J. Romanet n, E. Christiansen n, J. Niemuth n , C. Williams n, M. Breen n  ...

author keywords: Amphibian; Bufonidae; Immunogenetics; MHC; TLR; Transcriptomics
topics (OpenAlex): Amphibian and Reptile Biology; Aquaculture disease management and microbiota; Animal Behavior and Reproduction
TL;DR: Comparison transcriptomics is used to examine the diversity of toll-like receptors and major histocompatibility complex sequences across three individual Wyoming toads and finds reduced diversity at MHC genes compared to bufonid species with a similar history of bottleneck events. (via Semantic Scholar)
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15. Life on Land (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 29, 2022

2021 journal article

Single-minded 2 is required for left-right asymmetric stomach morphogenesis

DEVELOPMENT, 148(17).

By: B. Wyatt n, N. Amin n, K. Bagley n, D. Wcisel n, M. Dush n, J. Yoder n , N. Nascone-Yoder n 

author keywords: right asymmetry; Stomach; Morphogenesis; Pitx2; Sim2; Down syndrome; Frog
MeSH headings : Animals; Anura; Basic Helix-Loop-Helix Transcription Factors / genetics; Basic Helix-Loop-Helix Transcription Factors / metabolism; Body Patterning; Embryo, Nonmammalian; Endoderm / embryology; Endoderm / metabolism; Gene Expression Regulation, Developmental; Homeodomain Proteins / genetics; Homeodomain Proteins / metabolism; Morphogenesis; Stomach / embryology; Transcription Factors / genetics; Transcription Factors / metabolism
topics (OpenAlex): Congenital heart defects research; Developmental Biology and Gene Regulation
TL;DR: It is demonstrated that sim2 functions downstream of LR patterning cues to regulate key cellular properties and behaviors in the left stomach epithelium that drive asymmetric curvature, and has implications for dose-dependent roles of laterality factors in non-laterality-related birth defects. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 27, 2021

2021 article

The bowfin genome illuminates the developmental evolution of ray-finned fishes

Thompson, A. W., Hawkins, M. B., Parey, E., Wcisel, D. J., Ota, T., Kawasaki, K., … Braasch, I. (2021, August 30). NATURE GENETICS, Vol. 8.

By: A. Thompson *, M. Hawkins *, E. Parey *, D. Wcisel n, T. Ota *, K. Kawasaki *, E. Funk *, M. Losilla * ...

MeSH headings : Animals; Biological Evolution; Chromatin / genetics; Evolution, Molecular; Fishes; Genome / genetics; Skates, Fish / genetics; Skates, Fish / immunology; Skates, Fish / physiology; Whole Genome Sequencing
topics (OpenAlex): Genomics and Phylogenetic Studies; Chromosomal and Genetic Variations; Aquaculture disease management and microbiota
TL;DR: A chromosome-level genome assembly for bowfin is presented that enables gene-order analyses, settling long-debated neopterygian phylogenetic relationships and investigates the evolution of immune, scale, respiratory and fin skeletal systems and identifies hundreds of gene-regulatory loci conserved across vertebrates. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 7, 2021

2017 journal article

Spotted Gar and the Evolution of Innate Immune Receptors

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 328(7), 666–684.

By: D. Wcisel n, T. Ota *, G. Litman* & J. Yoder n 

MeSH headings : Amino Acid Sequence; Animals; Biological Evolution; Fishes / genetics; Fishes / immunology; Gene Expression Regulation / immunology; Immunity, Innate / genetics; Immunity, Innate / physiology
topics (OpenAlex): Immune Response and Inflammation; Immune Cell Function and Interaction; interferon and immune responses
TL;DR: It appears that both the total genome duplication and different patterns of genetic selection have influenced the derivation and stabilization of innate immune genes in a substantial manner during the course of vertebrate evolution. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2016 journal article

Alternative haplotypes of antigen processing genes in zebrafish diverged early in vertebrate evolution

Proceedings of the National Academy of Sciences, 113(34), E5014–E5023.

By: S. McConnell *, K. Hernandez *, D. Wcisel n, R. Kettleborough*, D. Stemple *, J. Yoder n , J. Andrade *, J. de Jong *

author keywords: comparative genomics; proteasome and TAP evolution; major histocompatibility; MHC class I pathway; CG2 clonal zebrafish
MeSH headings : Animals; Antigen Presentation; Biological Evolution; Cloning, Organism; Cysteine Endopeptidases / classification; Cysteine Endopeptidases / genetics; Cysteine Endopeptidases / immunology; Genome; Haplotypes; High-Throughput Nucleotide Sequencing; Histocompatibility Antigens Class I / classification; Histocompatibility Antigens Class I / genetics; Histocompatibility Antigens Class I / immunology; Phylogeny; Proteasome Endopeptidase Complex / genetics; Proteasome Endopeptidase Complex / immunology; Protein Isoforms / classification; Protein Isoforms / genetics; Protein Isoforms / immunology; Transcriptome; Zebrafish / classification; Zebrafish / genetics; Zebrafish / immunology; Zebrafish Proteins / classification; Zebrafish Proteins / genetics; Zebrafish Proteins / immunology
topics (OpenAlex): T-cell and B-cell Immunology; Immune Cell Function and Interaction; Aquaculture disease management and microbiota
TL;DR: Comparison analysis shows that antigen processing gene diversity is far more extensive than previously realized, implying distinct immune functions and conserved roles in shaping MHC pathway evolution throughout vertebrates. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2016 journal article

The confounding complexity of innate immune receptors within and between teleost species

Fish & Shellfish Immunology, 53, 24–34.

By: D. Wcisel n & J. Yoder n 

author keywords: Gene content haplotype; Novel immune-type receptors; Diverse immunoglobulin domain containing proteins; Polymeric immunoglobulin receptor-like proteins; Novel immunoglobulin-like transcripts
MeSH headings : Animals; Fishes / genetics; Fishes / immunology; Genetic Variation; Genome; Immunity, Innate; Receptors, Immunologic / genetics
topics (OpenAlex): Immune Cell Function and Interaction; Aquaculture disease management and microbiota; T-cell and B-cell Immunology
TL;DR: By defining which teleost lineages encode (and do not encode) different IIir families, predictions can be made about the presence (or absence) of specific IIIR families in each teleost lineage. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2016 journal article

The identification of additional zebrafish DICP genes reveals haplotype variation and linkage to MHC class I genes

Immunogenetics, 68(4), 295–312.

By: I. Rodriguez-Nunez  n, D. Wcisel n, R. Litman*, G. Litman*, J. Yoder n  & Immunogenetics

author keywords: Innate immunity; Immunoglobulin domain; Haplotype; Polymorphism; Immune receptor
MeSH headings : Animals; Gene Expression Regulation, Developmental; Genes, MHC Class I / genetics; Genes, MHC Class I / immunology; Genetic Linkage; Haplotypes; Immunity, Innate; Immunoglobulins / genetics; Lipids / genetics; Receptors, Immunologic / genetics; Receptors, Immunologic / immunology; Zebrafish / genetics; Zebrafish / growth & development; Zebrafish / immunology; Zebrafish Proteins / genetics; Zebrafish Proteins / immunology
topics (OpenAlex): Immune Cell Function and Interaction; Zebrafish Biomedical Research Applications; Aquaculture disease management and microbiota
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14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2016 journal article

The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons

Nature Genetics, 48(4), 427–437.

By: I. Braasch, A. Gehrke, J. Smith, K. Kawasaki *, T. Manousaki *, J. Pasquier*, A. Amores, T. Desvignes ...

MeSH headings : Animals; Evolution, Molecular; Female; Fishes / genetics; Fishes / metabolism; Genome; Humans; Karyotype; Models, Genetic; Organ Specificity; Sequence Analysis, DNA; Transcriptome
topics (OpenAlex): RNA Research and Splicing; Cancer-related molecular mechanisms research; interferon and immune responses
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14. Life Below Water (OpenAlex)
Sources: NC State University Libraries, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2014 journal article

Multigene families of immunoglobulin domain-containing innate immune receptors in zebrafish: Deciphering the differences

Developmental & Comparative Immunology, 46(1), 24–34.

By: I. Rodríguez-Nunez  n, D. Wcisel n, G. Litman* & J. Yoder n 

author keywords: Novel immune-type receptors; Diverse immunoglobulin domain containing proteins; Polymeric immunoglobulin receptor-like proteins; Novel immunoglobulin-like transcripts; Leukocyte immune-type receptors
MeSH headings : Animals; Haplotypes; Receptors, Immunologic / chemistry; Receptors, Immunologic / genetics; Receptors, Immunologic / immunology; Zebrafish / genetics; Zebrafish / immunology; Zebrafish Proteins / chemistry; Zebrafish Proteins / genetics; Zebrafish Proteins / immunology
topics (OpenAlex): Aquaculture disease management and microbiota; Invertebrate Immune Response Mechanisms; Immune Cell Function and Interaction
TL;DR: Five large multigene families encoding innate-type immune receptors that are comprised of immunoglobulin domains have been identified in bony fish, of which four do not possess definable mammalian orthologs. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

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