Works (13)
Updated: December 16th, 2024 12:05
2021 journal article
Assessment of Sensory Thresholds in Dogs using Mechanical and Hot Thermal Quantitative Sensory Testing
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 10(176).
MeSH headings : Animals; Dogs; Hot Temperature; Humans; Osteoarthritis; Pain; Pain Measurement / methods; Pain Threshold / physiology; Reproducibility of Results; Sensory Thresholds / physiology
TL;DR:
The QST operator and handler should be familiar and comfortable with handling dogs and interpreting dogs' behavioral responses to potentially painful stimuli to determine the endpoint of testing, reduce stress, and maintain safety during the testing process.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 15, 2021
2021 journal article
Serum artemin is not correlated with sensitivity within dogs with naturally occurring osteoarthritis pain
SCIENTIFIC REPORTS, 11(1).
MeSH headings : Animals; Arthralgia / diagnosis; Arthralgia / etiology; Dogs; Female; Male; Nerve Tissue Proteins / blood; Osteoarthritis / blood; Osteoarthritis / complications; Pain Threshold; Severity of Illness Index; Symptom Assessment
TL;DR:
Serum ARTN was not associated with the degree of sensitization within dogs with OAP, and across dogs with varying OAP severity, there did not find any association between ARTN, and clinical measures of joint pain and disability, although a relationship between Artemin and joint pain was not ruled out.
(via Semantic Scholar)
open access via www.nature.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 19, 2021
2018 journal article
Quantitative sensory testing in dogs with painful disease: A window to pain mechanisms?
VETERINARY JOURNAL, 243, 33–41.
author keywords: Algoplasticity; Dog; Quantitative sensory testing
MeSH headings : Animals; Dog Diseases / diagnosis; Dog Diseases / etiology; Dogs; Pain / diagnosis; Pain / etiology; Pain / veterinary; Pain Measurement / instrumentation; Pain Measurement / methods; Pain Measurement / veterinary; Pain Threshold
TL;DR:
A narrative review describes the investigations into QST in clinical populations of dogs to date, and discusses the potential benefits and limitations of such testing.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 11, 2019
2018 journal article
Replicate effects and test-retest reliability of quantitative sensory threshold testing in dogs with and without chronic pain
Veterinary Anaesthesia and Analgesia, 44(3), 615–624.
Sources: NC State University Libraries, NC State University Libraries, ORCID
Added: August 6, 2018
2016 journal article
Alfaxalone Anaesthesia Facilitates Electrophysiological Recordings of Nociceptive Withdrawal Reflexes in Dogs (Canis familiaris)
PLOS ONE, 11(7).
MeSH headings : Anesthesia / methods; Anesthetics / administration & dosage; Animals; Consciousness / drug effects; Dogs; Electrophysiological Phenomena; Male; Osteoarthritis / diagnosis; Osteoarthritis / physiopathology; Osteoarthritis / veterinary; Pain / diagnosis; Pain / drug therapy; Pain / veterinary; Pregnanediones / administration & dosage; Reflex / drug effects
TL;DR:
Development of a suitable anaesthetic protocol in experimental dogs, which facilitated electrophysiological nociceptive withdrawal reflex assessment, may increase the acceptability of using the technique in owned dogs with naturally occurring osteoarthritis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2016 journal article
Comparison of thermal and mechanical quantitative sensory testing in client-owned dogs with chronic naturally occurring pain and normal dogs
The Veterinary Journal, 210, 95–97.
Contributors: M. Freire n, n , B. Case n, A. Thomson n & B. Lascelles n
author keywords: Canine; Central Sensitization; Chronic pain; Mechanical sensory threshold; Thermal sensory threshold
MeSH headings : Animals; Central Nervous System Sensitization; Dog Diseases / physiopathology; Dogs; Osteoarthritis / physiopathology; Osteoarthritis / veterinary; Pain / physiopathology; Pain / veterinary; Sensory Thresholds
TL;DR:
Whether QST is different between dogs with chronic pain and normal dogs needs further investigation using a larger group of animals and age, weight and sex matched groups.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Crossref
Added: January 25, 2020
2016 journal article
Mechanical and Thermal Sensory Testing in Normal Chondrodystrophoid Dogs and Dogs with Spinal Cord Injury caused by Thoracolumbar Intervertebral Disc Herniations
Journal of Veterinary Internal Medicine, 30(2), 627–635.
Contributors: A. Gorney n, S. Blau n, C. Dohse n, E. Griffith n , K. Williams n, J. Lim n, n , B. Lascelles n, N. Olby n
author keywords: Allodynia; Mechanical threshold; Nociception; Quantitative sensory testing; Thermal threshold
MeSH headings : Animals; Cold Temperature; Dog Diseases / diagnosis; Dogs; Female; Hot Temperature; Intervertebral Disc Displacement / diagnosis; Intervertebral Disc Displacement / veterinary; Male; Pressure; Sensory Thresholds / physiology; Spinal Cord Injuries / diagnosis; Spinal Cord Injuries / veterinary
TL;DR:
The differences in sensation among neurologic grades indicate that these techniques can be used to further characterize recovery of SCI dogs and can be measured reliably in chondrodystrophoid dogs and are altered by SCI.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2016 journal article
Widespread somatosensory sensitivity in naturally occurring canine model of osteoarthritis
PAIN, 157(6), 1325–1332.
Contributors: n , E. Helgeson n, B. Case n, M. Gruen n , W. Maixner n & B. Lascelles n
author keywords: Animal model; Osteoarthritis; Spontaneous osteoarthritis model; Quantitative sensory testing
MeSH headings : Animals; Arthralgia / physiopathology; Arthralgia / veterinary; Central Nervous System Sensitization / physiology; Dogs; Osteoarthritis / physiopathology; Osteoarthritis / veterinary; Pain Measurement; Pain Threshold / physiology; Physical Stimulation; Sensory Thresholds / physiology
TL;DR:
The canine spontaneous OA model is associated with somatosensory sensitivity, likely indicative of central sensitization in human patients' chronic pain, and is validated as an appropriate model of the human OA pain condition.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2015 journal article
A canine-specific anti-nerve growth factor antibody alleviates pain and improves mobility and function in dogs with degenerative joint disease-associated pain
BMC VETERINARY RESEARCH, 11(1).
Contributors: B. Lascelles n, n , B. Case n, M. Freire *, J. Innes, A. Drew*, D. Gearing*
author keywords: Nerve growth factor; Dog; Antibody; Pain; Model; Osteoarthritis; Accelerometry; Actimetry
MeSH headings : Animals; Antibodies / immunology; Antibodies / therapeutic use; Dog Diseases / therapy; Dogs; Double-Blind Method; Female; Immunotherapy / veterinary; Male; Nerve Growth Factor / immunology; Osteoarthritis / therapy; Osteoarthritis / veterinary; Pain / drug therapy; Pain / veterinary
TL;DR:
These pilot data demonstrate a positive analgesic effect of anti-NGF antibody in dogs suffering from chronic pain, similar to that expected with an NSAID.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
Initial evaluation of nighttime restlessness in a naturally occurring canine model of osteoarthritis pain
Peerj, 3(2), e772.
Contributors: n , A. Tomas n, A. Motsinger-Reif n & B. Lascelles n
author keywords: Accelerometry; Dog; Pain; Model; Spontaneous; Accelerometry
TL;DR:
Although accelerometry does not appear to be useful, this model has potential to model the human pain-related nighttime sleep disturbance, and other outcome measures should be explored in this model.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2014 journal article
Clinical comparison and short-term radiographic evaluation of Tight Rope and Lateral Suture procedures for dogs after cranial cruciate ligament rupture
Veterinarni Medicina, 59(10), 502–505. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000346742400005&KeyUID=WOS:000346742400005
Source: ORCID
Added: March 6, 2023
2012 journal article
Mechanical testing of orthopaedic suture material and a crimp clamp system for the extracapsular stabilisation of canine cruciate-deficient stifles
Veterinarni Medicina, 57(11), 597–602. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000313211200005&KeyUID=WOS:000313211200005
Source: ORCID
Added: March 6, 2023
2012 journal article
Use of the modified Insall Salvati method for determination of vertical patellar position in dogs with and without cranial cruciate ligament rupture considering the morphology of the cranio-proximal tibia
Acta Veterinaria Brno, 81(4), 403–407.
TL;DR:
It is concluded that the morphology of the cranioproximal tibia and the height of insertion point of the patellar ligament do not have an influence on the value of the modified IS index both in healthy dogs and in dogs with cranial cruciate ligament rupture.
(via Semantic Scholar)
Source: ORCID
Added: March 6, 2023
Employment
Updated: August 11th, 2022 13:59
2022 - present
NC State University Raleigh, NC, US
Assistant Professor of Orthopedics
College of Veterinary Medicine
2015 - 2016
Oregon State University Corvallis, OR, US
Small Animal Rotating Internship
College of Veterinary Medicine
2013 - 2015
North Carolina State University Raleigh, NC, US
Research fellow
College of Veterinary Medicine
Education
Updated: May 12th, 2017 22:52
2009 - 2013
University of Veterinary Medicine and Pharmacy Kosice, SK
PhD
2001 - 2008
University of Veterinary Medicine and Pharmacy Kosice, SK
DVM
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