David Knazovicky

Experienced Veterinarian with a demonstrated history of working in the academic veterinary industry. Skilled in Veterinary Medicine - Small Animal Orthopedic Surgery, Clinical Research, and Teaching. Strong healthcare services professional with a Doctor of Philosophy (PhD) focused in Small/Companion Animal Surgery and Medicine from University of Veterinary Medicine and Pharmacy in Kosice.

Works (18)

Updated: March 3rd, 2025 05:01

2021 journal article

Assessment of Sensory Thresholds in Dogs using Mechanical and Hot Thermal Quantitative Sensory Testing

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 10(176).

By: R. Cunningham  n, R. Park n, D. Knazovicky n , B. Lascelles  n & M. Gruen n 

MeSH headings : Animals; Dogs; Hot Temperature; Humans; Osteoarthritis; Pain; Pain Measurement / methods; Pain Threshold / physiology; Reproducibility of Results; Sensory Thresholds / physiology
TL;DR: The QST operator and handler should be familiar and comfortable with handling dogs and interpreting dogs' behavioral responses to potentially painful stimuli to determine the endpoint of testing, reduce stress, and maintain safety during the testing process. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: November 15, 2021

2021 journal article

Serum artemin is not correlated with sensitivity within dogs with naturally occurring osteoarthritis pain

SCIENTIFIC REPORTS, 11(1).

By: A. Gupta n , L. Chiavaccini n, L. Minnema n, K. Chiu n, D. Knazovicky n , J. Hash n, S. Mishra n, B. Lascelles  n

MeSH headings : Animals; Arthralgia / diagnosis; Arthralgia / etiology; Dogs; Female; Male; Nerve Tissue Proteins / blood; Osteoarthritis / blood; Osteoarthritis / complications; Pain Threshold; Severity of Illness Index; Symptom Assessment
TL;DR: Serum ARTN was not associated with the degree of sensitization within dogs with OAP, and across dogs with varying OAP severity, there did not find any association between ARTN, and clinical measures of joint pain and disability, although a relationship between Artemin and joint pain was not ruled out. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: April 19, 2021

2018 journal article

Quantitative sensory testing in dogs with painful disease: A window to pain mechanisms?

VETERINARY JOURNAL, 243, 33–41.

By: J. Hunt, D. Knazovicky n , B. Lascelles  n & J. Murrell*

author keywords: Algoplasticity; Dog; Quantitative sensory testing
MeSH headings : Animals; Dog Diseases / diagnosis; Dog Diseases / etiology; Dogs; Pain / diagnosis; Pain / etiology; Pain / veterinary; Pain Measurement / instrumentation; Pain Measurement / methods; Pain Measurement / veterinary; Pain Threshold
TL;DR: A narrative review describes the investigations into QST in clinical populations of dogs to date, and discusses the potential benefits and limitations of such testing. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: February 11, 2019

2017 journal article

Replicate effects and test-retest reliability of quantitative sensory threshold testing in dogs with and without chronic pain

Veterinary Anaesthesia and Analgesia, 44(3), 615–624.

By: D. Knazovicky n , E. Helgeson *, B. Case n, A. Thomson n, M. Gruen n , W. Maixner*, B. Lascelles  n

Sources: NC State University Libraries, NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

Replicate effects and test–retest reliability of quantitative sensory threshold testing in dogs with and without chronic pain

Veterinary Anaesthesia and Analgesia, 44(3), 615–624.

By: D. Knazovicky n , E. Helgeson *, B. Case n, A. Thomson  n, M. Gruen  n, W. Maixner*, B. Lascelles  n

author keywords: central sensitization; chronic pain; dogs; quantitative sensory testing; replicate effect
MeSH headings : Animals; Chronic Pain / physiopathology; Chronic Pain / veterinary; Cold Temperature; Dog Diseases / physiopathology; Dogs; Hot Temperature; Osteoarthritis / physiopathology; Osteoarthritis / veterinary; Pain Measurement; Pain Threshold / physiology; Pressure; Prospective Studies; Reproducibility of Results; Sensory Thresholds / physiology
TL;DR: Evaluated replicate effects and test-retest reliability of mechanical and thermal quantitative sensory testing (QST) in normal dogs and dogs with osteoarthritis-associated pain showed variability over time, particularly for EVF and hot thermal stimuli. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: June 30, 2019

2016 journal article

Alfaxalone Anaesthesia Facilitates Electrophysiological Recordings of Nociceptive Withdrawal Reflexes in Dogs (Canis familiaris)

PLOS ONE, 11(7).

By: J. Hunt *, J. Murrell *, D. Knazovicky n , J. Harris *, S. Kelly*, T. Knowles *, B. Lascelles  n

Ed(s): M. Sakakibara

MeSH headings : Anesthesia / methods; Anesthetics / administration & dosage; Animals; Consciousness / drug effects; Dogs; Electrophysiological Phenomena; Male; Osteoarthritis / diagnosis; Osteoarthritis / physiopathology; Osteoarthritis / veterinary; Pain / diagnosis; Pain / drug therapy; Pain / veterinary; Pregnanediones / administration & dosage; Reflex / drug effects
TL;DR: Development of a suitable anaesthetic protocol in experimental dogs, which facilitated electrophysiological nociceptive withdrawal reflex assessment, may increase the acceptability of using the technique in owned dogs with naturally occurring osteoarthritis. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2016 journal article

Comparison of thermal and mechanical quantitative sensory testing in client-owned dogs with chronic naturally occurring pain and normal dogs

The Veterinary Journal, 210, 95–97.

By: M. Freire  n, D. Knazovicky n , B. Case n, A. Thomson  n & B. Lascelles  n

Contributors: M. Freire  n, D. Knazovicky n , B. Case n, A. Thomson  n & B. Lascelles  n

author keywords: Canine; Central Sensitization; Chronic pain; Mechanical sensory threshold; Thermal sensory threshold
MeSH headings : Animals; Central Nervous System Sensitization; Dog Diseases / physiopathology; Dogs; Osteoarthritis / physiopathology; Osteoarthritis / veterinary; Pain / physiopathology; Pain / veterinary; Sensory Thresholds
TL;DR: Whether QST is different between dogs with chronic pain and normal dogs needs further investigation using a larger group of animals and age, weight and sex matched groups. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: January 25, 2020

2016 journal article

Mechanical and Thermal Sensory Testing in Normal Chondrodystrophoid Dogs and Dogs with Spinal Cord Injury caused by Thoracolumbar Intervertebral Disc Herniations

Journal of Veterinary Internal Medicine, 30(2), 627–635.

By: A. Gorney n, S. Blau n, C. Dohse n, E. Griffith n , K. Williams n, J. Lim n, D. Knazovicky n , B. Lascelles  n, N. Olby n 

Contributors: A. Gorney n, S. Blau n, C. Dohse n, E. Griffith n , K. Williams n, J. Lim n, D. Knazovicky n , B. Lascelles  n, N. Olby n 

author keywords: Allodynia; Mechanical threshold; Nociception; Quantitative sensory testing; Thermal threshold
MeSH headings : Animals; Cold Temperature; Dog Diseases / diagnosis; Dogs; Female; Hot Temperature; Intervertebral Disc Displacement / diagnosis; Intervertebral Disc Displacement / veterinary; Male; Pressure; Sensory Thresholds / physiology; Spinal Cord Injuries / diagnosis; Spinal Cord Injuries / veterinary
TL;DR: The differences in sensation among neurologic grades indicate that these techniques can be used to further characterize recovery of SCI dogs and can be measured reliably in chondrodystrophoid dogs and are altered by SCI. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2016 journal article

Widespread somatosensory sensitivity in naturally occurring canine model of osteoarthritis

PAIN, 157(6), 1325–1332.

By: D. Knazovicky n , E. Helgeson  n, B. Case n, M. Gruen n , W. Maixner n & B. Lascelles  n

Contributors: D. Knazovicky n , E. Helgeson  n, B. Case n, M. Gruen n , W. Maixner n & B. Lascelles  n

author keywords: Animal model; Osteoarthritis; Spontaneous osteoarthritis model; Quantitative sensory testing
MeSH headings : Animals; Arthralgia / physiopathology; Arthralgia / veterinary; Central Nervous System Sensitization / physiology; Dogs; Osteoarthritis / physiopathology; Osteoarthritis / veterinary; Pain Measurement; Pain Threshold / physiology; Physical Stimulation; Sensory Thresholds / physiology
TL;DR: The canine spontaneous OA model is associated with somatosensory sensitivity, likely indicative of central sensitization in human patients' chronic pain, and is validated as an appropriate model of the human OA pain condition. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2015 journal article

A canine-specific anti-nerve growth factor antibody alleviates pain and improves mobility and function in dogs with degenerative joint disease-associated pain

BMC VETERINARY RESEARCH, 11(1).

By: B. Lascelles  n, D. Knazovicky n , B. Case n, M. Freire *, J. Innes, A. Drew*, D. Gearing*

Contributors: B. Lascelles  n, D. Knazovicky n , B. Case n, M. Freire *, J. Innes, A. Drew*, D. Gearing*

author keywords: Nerve growth factor; Dog; Antibody; Pain; Model; Osteoarthritis; Accelerometry; Actimetry
MeSH headings : Animals; Antibodies / immunology; Antibodies / therapeutic use; Dog Diseases / therapy; Dogs; Double-Blind Method; Female; Immunotherapy / veterinary; Male; Nerve Growth Factor / immunology; Osteoarthritis / therapy; Osteoarthritis / veterinary; Pain / drug therapy; Pain / veterinary
TL;DR: These pilot data demonstrate a positive analgesic effect of anti-NGF antibody in dogs suffering from chronic pain, similar to that expected with an NSAID. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2015 journal article

Initial evaluation of nighttime restlessness in a naturally occurring canine model of osteoarthritis pain

PeerJ, 3(2), e772.

By: D. Knazovicky n , A. Tomas n, A. Motsinger-Reif n & B. Lascelles  n

Contributors: D. Knazovicky n , A. Tomas n, A. Motsinger-Reif n & B. Lascelles  n

author keywords: Accelerometry; Dog; Pain; Model; Spontaneous; Accelerometry
TL;DR: Although accelerometry does not appear to be useful, this model has potential to model the human pain-related nighttime sleep disturbance, and other outcome measures should be explored in this model. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, NC State University Libraries, Crossref, NC State University Libraries
Added: August 6, 2018

2014 journal article

Clinical comparison and short-term radiographic evaluation of Tight Rope and Lateral Suture procedures for dogs after cranial cruciate ligament rupture

Veterinarni Medicina, 59(10), 502–505. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000346742400005&KeyUID=WOS:000346742400005

By: V. Ledecky, M. Hluchy, R. Freilichman, S. Hornak & D. Knazovicky 

Contributors: V. Ledecky, M. Hluchy, R. Freilichman, S. Hornak & D. Knazovicky 

gateway.webofknowledge.com
Source: ORCID
Added: March 6, 2023

2012 journal article

Mechanical testing of orthopaedic suture material and a crimp clamp system for the extracapsular stabilisation of canine cruciate-deficient stifles

Veterinarni Medicina, 57(11), 597–602. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000313211200005&KeyUID=WOS:000313211200005

By: V. Ledecky, D. Knazovicky , M. Badida, L. Dulebova, M. Hluchy & S. Hornak

Contributors: V. Ledecky, D. Knazovicky , M. Badida, L. Dulebova, M. Hluchy & S. Hornak

gateway.webofknowledge.com
Source: ORCID
Added: March 6, 2023

2012 journal article

Use of the modified Insall Salvati method for determination of vertical patellar position in dogs with and without cranial cruciate ligament rupture considering the morphology of the cranio-proximal tibia

Acta Veterinaria Brno, 81(4), 403–407.

By: D. Knazovicky* , V. Ledecky*, M. Hluchy* & M. Durej*

Contributors: D. Knazovicky* , V. Ledecky*, M. Hluchy* & M. Durej*

TL;DR: It is concluded that the morphology of the cranioproximal tibia and the height of insertion point of the patellar ligament do not have an influence on the value of the modified IS index both in healthy dogs and in dogs with cranial cruciate ligament rupture. (via Semantic Scholar)
Source: ORCID
Added: March 6, 2023

journal article

Ice water immersion does not activate diffuse noxious inhibitory controls of spinal reflexes in sedated or anaesthetised dogs (Canis familiaris): A Pilot Study

Hunt, J., Knazovicky, D., Harris, J., Kelly, S., Knowles, T. G., Murrell, J., & Lascelles, B. D. X. Front. Pain Res.

By: J. Hunt, D. Knazovicky , J. Harris, S. Kelly, T. Knowles, J. Murrell, B. Lascelles

Source: NC State University Libraries
Added: March 2, 2025

conference paper

Ice water immersion does not activate diffuse noxious inhibitory controls of spinal reflexes in sedated or anaesthetised dogs (Canis familiaris): A Pilot Study

Maixner Pain Research Symposium 2024. Presented at the Maixner Pain Research Symposium 2024, Durham, NC.

By: J. Hunt, D. Knazovicky , J. Harris, S. Kelly, T. Knowles, J. Murrell, B. Lascelles

Event: Maixner Pain Research Symposium 2024 at Durham, NC on November 8, 2024

Source: NC State University Libraries
Added: March 2, 2025

conference paper

Intra-articular Pressures of the Shoulder and Stifle during Arthroscopy

VOS 52nd Annual Conference. Presented at the VOS 52nd Annual Conference, Breckenridge, Colorado.

By: M. Baldeon & D. Knazovicky 

Event: VOS 52nd Annual Conference at Breckenridge, Colorado on February 8-15, 2025

Source: NC State University Libraries
Added: March 2, 2025

conference paper

Quantitative sensory testing in dogs with spontaneous osteoarthritis

Maixner Pain Research Symposium 2024. Presented at the Maixner Pain Research Symposium 2024, Durham, NC.

By: J. Hunt, D. Knazovicky , M. Goff, J. Harris, T. Knowles, B. Lascelles, M. Enomoto, M. Mendl, B. Whay, J. Murrell

Event: Maixner Pain Research Symposium 2024 at Durham, NC on November 8, 2024

Source: NC State University Libraries
Added: March 2, 2025

Employment

Updated: August 11th, 2022 13:59

2022 - present

NC State University Raleigh, NC, US
Assistant Professor of Orthopedics College of Veterinary Medicine

2015 - 2016

Oregon State University Corvallis, OR, US
Small Animal Rotating Internship College of Veterinary Medicine

2013 - 2015

North Carolina State University Raleigh, NC, US
Research fellow College of Veterinary Medicine

Education

Updated: May 12th, 2017 22:52

2009 - 2013

University of Veterinary Medicine and Pharmacy Kosice, SK
PhD

2001 - 2008

University of Veterinary Medicine and Pharmacy Kosice, SK
DVM

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