@article{little_redding_gerard_2009, title={Osseous cyst-like lesions of the lateral infertubercular groove of the proximal humerus: A report of 5 cases}, volume={21}, ISSN={["2042-3292"]}, DOI={10.2746/095777308X382678}, abstractNote={Summary}, number={2}, journal={EQUINE VETERINARY EDUCATION}, author={Little, D. and Redding, W. R. and Gerard, M. P.}, year={2009}, month={Feb}, pages={60–66} } @article{fogle_gerard_elce_little_morton_correa_blikslager_2008, title={Analysis of Sodium Carboxymethylcellulose Administration and Related Factors Associated with Postoperative Colic and Survival in Horses with Small Intestinal Disease}, volume={37}, ISSN={0161-3499 1532-950X}, url={http://dx.doi.org/10.1111/j.1532-950X.2008.00420.x}, DOI={10.1111/j.1532-950X.2008.00420.x}, abstractNote={Objective—To analyze the effect of the intraoperative use of sodium carboxymethylcellulose (CBMC) and related perioperative factors on postoperative colic and survival in horses that had abdominal surgery for colic.}, number={6}, journal={Veterinary Surgery}, publisher={Wiley}, author={Fogle, Callie A. and Gerard, Mathew P. and Elce, Yvonne A. and Little, Dianne and Morton, Alison J. and Correa, Maria T. and Blikslager, Anthony T.}, year={2008}, month={Aug}, pages={558–563} } @article{little_jones_blikslager_2007, title={Cyclooxygenase (COX) Inhibitors and the Intestine}, volume={21}, ISSN={0891-6640 1939-1676}, url={http://dx.doi.org/10.1111/j.1939-1676.2007.tb02978.x}, DOI={10.1111/j.1939-1676.2007.tb02978.x}, abstractNote={Nonsteroidal anti‐inflammatory drugs (NSAIDs) have long been used for the treatment of pain and inflammation because of their inhibitory effects on cyclooxygenase (COX). For almost as long as NSAIDs have been in use, multiple adverse effects have been noted. Assessment of many of these adverse effects have been complicated because of the discovery of multiple splice variants of the cox gene, and a greater array of COX inhibitors, especially the COX‐2 selective inhibitors have become available. Some of these adverse effects cannot be readily explained by the effect of these drugs on COX. This has sparked a new field of investigation into the COX‐independent effects of the COX inhibitors. The major noncyclooxygenase targets of the COX inhibitors of particular relevance to inflammation and the gastrointestinal tract are phosphatidylinositol 3'‐kinase Akt signaling, uncoupling of oxidative phosphorylation, PPARγ, nuclear factor kB, mitogen activated protein kinases, and heat shock proteins.}, number={3}, journal={Journal of Veterinary Internal Medicine}, publisher={Wiley}, author={Little, Dianne and Jones, Samuel L. and Blikslager, Anthony T.}, year={2007}, month={May}, pages={367–377} } @article{little_brown_campbell_moeser_davis_blikslager_2007, title={Effects of the cyclooxygenase inhibitor meloxicam on recovery of ischemia-injured equine jejunum}, volume={68}, ISSN={0002-9645}, url={http://dx.doi.org/10.2460/ajvr.68.6.614}, DOI={10.2460/ajvr.68.6.614}, abstractNote={Abstract}, number={6}, journal={American Journal of Veterinary Research}, publisher={American Veterinary Medical Association (AVMA)}, author={Little, Dianne and Brown, S. Aubrey and Campbell, Nigel B. and Moeser, Adam J. and Davis, Jennifer L. and Blikslager, Anthony T.}, year={2007}, month={Jun}, pages={614–624} } @article{moeser_klok_ryan_wooten_little_cook_blikslager_2007, title={Stress signaling pathways activated by weaning mediate intestinal dysfunction in the pig}, volume={292}, ISSN={0193-1857 1522-1547}, url={http://dx.doi.org/10.1152/ajpgi.00197.2006}, DOI={10.1152/ajpgi.00197.2006}, abstractNote={Weaning in the piglet is a stressful event associated with gastrointestinal disorders and increased disease susceptibility. Although stress is thought to play a role in postweaning intestinal disease, the mechanisms by which stress influences intestinal pathophysiology in the weaned pig are not understood. The objectives of these experiments were to investigate the impact of weaning on gastrointestinal health in the pig and to assess the role of stress signaling pathways in this response. Nineteen-day-old pigs were weaned, and mucosal barrier function and ion transport were assessed in jejunal and colonic tissues mounted on Ussing chambers. Weaning caused marked disturbances in intestinal barrier function, as demonstrated by significant ( P < 0.01) reductions in transepithelial electrical resistance and increases in intestinal permeability to [3H]mannitol in both the jejunum and colon compared with intestinal tissues from age-matched, unweaned control pigs. Weaned intestinal tissues exhibited increased intestinal secretory activity, as demonstrated by elevated short-circuit current that was sensitive to treatment with tetrodotoxin and indomethacin, suggesting activation of enteric neural and prostaglandin synthesis pathways in weaned intestinal tissues. Western blot analyses of mucosal homogenates showed increased expression of corticotrophin-releasing factor (CRF) receptor 1 in the jejunum and colon of weaned intestinal tissues. Pretreatment of pigs with the CRF receptor antagonist α-helical CRF(9–41), which was injected intraperitoneally 30 min prior to weaning, abolished the stress-induced mucosal changes. Our results indicate that weaning stress induces mucosal dysfunction mediated by intestinal CRF receptors and activated by enteric nerves and prostanoid pathways.}, number={1}, journal={American Journal of Physiology-Gastrointestinal and Liver Physiology}, publisher={American Physiological Society}, author={Moeser, Adam J. and Klok, Carin Vander and Ryan, Kathleen A. and Wooten, Jenna G. and Little, Dianne and Cook, Vanessa L. and Blikslager, Anthony T.}, year={2007}, month={Jan}, pages={G173–G181} } @article{davis_little_blikslager_papich_2006, title={Mucosal permeability of water-soluble drugs in the equine jejunum: a preliminary investigation}, volume={29}, ISSN={0140-7783 1365-2885}, url={http://dx.doi.org/10.1111/j.1365-2885.2006.00757.x}, DOI={10.1111/j.1365-2885.2006.00757.x}, abstractNote={Ussing chambers have been used to study the mucosal permeability of drugs in humans, rats and other species. This data can then be used to developin vitro/in vivocorrelations (IVIVC) for drugs based on the Biopharmaceutics Classification System (BCS). Due to the poor oral bioavailability of many drugs in the horse, this method may be useful for screening drugs before development to determine if they warrant further study. Cephalexin (CPX), marbofloxacin (MAR), metronidazole (MTZ) and fluconazole (FCZ) were chosen for this study based on the wide range of physicochemical properties and bioavailability in the horse. Permeability was ranked as follows: MTZ > FCZ > MAR > CPX. This correlated with the bioavailability (R2 = 0.633447), the Log P (R2 = 0.648517), as well as the molecular weight (R2 = 0.851208) of the drugs. Metronidazole induced a decrease in the tissue transepithelial resistance, suggestive of the possibility of tissue toxicity, which may have falsely increased its permeability. The low permeability of cephalexin across the tissue may indicate a lack of active transporters that are found in other species. From this study, we can conclude that the Ussing chamber is a promising method for determining mucosal permeability in the horse.}, number={5}, journal={Journal of Veterinary Pharmacology and Therapeutics}, publisher={Wiley}, author={Davis, J. L. and Little, D. and Blikslager, A. T. and Papich, M. G.}, year={2006}, month={Oct}, pages={379–385} } @article{brazik_luquire_little_2006, title={Pyrantel pamoate resistance in horses receiving daily administration of pyrantel tartrate}, volume={228}, DOI={10.2460/javma.228.1.101}, abstractNote={Abstract}, number={1}, journal={Journal of the American Veterinary Medical Association}, author={Brazik, E. L. and Luquire, J. T. and Little, D.}, year={2006}, pages={101–103} } @article{tschetter_blikslager_little_howard_woody_beex_crisman_2005, title={Detection of differentially regulated genes in ischaemic equine intestinal mucosa}, volume={37}, ISSN={["0425-1644"]}, DOI={10.2746/0425164054529382}, abstractNote={REASONS FOR PERFORMING STUDY Colic is a serious disease syndrome in horses. Much of the mortality is associated with ischaemic-injured intestine during strangulating obstruction, yet there is limited understanding of the associated molecular events. Identification of differentially expressed genes during ischaemic injury should expand our understanding of colic and may lead to novel targeted therapeutic approaches in the future. OBJECTIVE To isolate and identify differentially expressed genes in equine jejunum following a 2 h ischaemic event compared to normally perfused jejunum. METHODS Suppressive subtractive hybridisation was used to clone genes that are differentially expressed in equine jejunum injured by 2 h of complete ischaemia as compared to time-matched control jejunal tissues. Expression of selected clones was further evaluated by northern blot analysis. RESULTS Of the 384 clones selected, 157 were confirmed to possess cDNAs corresponding differentially expressed genes by dot blot analysis. Two genes, fatty acid binding protein 2 and calcium-activated chloride channel 4 were further confirmed to be differentially expressed by northern blot analysis. CONCLUSIONS Suppressive subtractive hybridisation can be used to detect changes in expression of a broad array of genes, as confirmed by northern blot analysis of selected genes. POTENTIAL RELEVANCE These initial results have identified a pool of equine intestinal epithelial genes that are differentially expressed following a 2 h ischaemic event. In particular, genes indicative of deranged metabolic activity and those potentially involved in early repair events were identified and may ultimately provide clues as to the nature of epithelial ischaemic injury in horses.}, number={4}, journal={EQUINE VETERINARY JOURNAL}, author={Tschetter, JR and Blikslager, AT and Little, D and Howard, RD and Woody, SL and Beex, LM and Crisman, MV}, year={2005}, month={Jul}, pages={319–324} } @article{little_white_young_blikslager_2005, title={Faecal bile loss in horses following small intestinal resection}, volume={37}, ISSN={["0425-1644"]}, DOI={10.2746/0425164054406883}, abstractNote={Equine Veterinary JournalVolume 37, Issue 1 p. 92-94 Faecal bile loss in horses following small intestinal resection D. LITTLE, D. LITTLE Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USASearch for more papers by this authorC. E. WHITE, C. E. WHITE Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USASearch for more papers by this authorK. M. YOUNG, K. M. YOUNG Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USASearch for more papers by this authorA. T. BLIKSLAGER, Corresponding Author A. T. BLIKSLAGER Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USADepartment of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USASearch for more papers by this author D. LITTLE, D. LITTLE Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USASearch for more papers by this authorC. E. WHITE, C. E. WHITE Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USASearch for more papers by this authorK. M. YOUNG, K. M. YOUNG Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USASearch for more papers by this authorA. T. BLIKSLAGER, Corresponding Author A. T. BLIKSLAGER Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USADepartment of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USASearch for more papers by this author First published: 05 January 2010 https://doi.org/10.2746/0425164054406883Citations: 3AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article.Citing Literature Volume37, Issue1January 2005Pages 92-94 RelatedInformation}, number={1}, journal={EQUINE VETERINARY JOURNAL}, author={Little, D and White, CE and Young, KM and Blikslager, AT}, year={2005}, month={Jan}, pages={92–94} } @article{little_tomlinson_blikslager_2005, title={Post operative neutrophilic inflammation in equine small intestine after manipulation and ischaemia}, volume={37}, ISSN={["0425-1644"]}, DOI={10.2746/0425164054529472}, abstractNote={REASONS FOR PERFORMING STUDY Post operative ileus (POI) remains an important cause of post operative morbidity and mortality in the horse. However, clinical progression of naturally occurring cases of POI in both horse and man does not entirely support the 'neurogenic' hypothesis as the sole mechanism of POI; and the hypothesis that inflammation plays a major role at 12-24 h after surgery requires validation. HYPOTHESIS An inflammatory infiltrate in the muscularis externa and myenteric plexus of equine jejunum is present 18 h following a period of ischaemia. METHODS Samples of normal jejunum, jejunum from the proximal resection margins of clinical cases and jejunum obtained 18 h after 1 or 2 h ischaemia or manipulation alone were evaluated for neutrophil infiltration. Samples obtained 18 h after surgery were additionally evaluated for leucocyte activation using calprotectin immunohistochemistry. Results were evaluated by ANOVA and P < 0.05 was considered significant. RESULTS Significant neutrophilic inflammation was identified in the samples from the proximal resection margins of clinical cases compared to uninjured jejunum. In experimental cases, neutrophilic inflammation appeared to be increased further by 18 h and was identified through all intestinal layers, particularly in the serosa, fascial planes around circular and longitudinal muscle fibres, and myenteric plexus. This elevated level of neutrophilic inflammation was mirrored by an increased number of calprotectin-positive cells in these intestinal layers, indicating leucocyte activation. CONCLUSIONS Significant neutrophilic inflammation occurs in equine jejunal myenteric layers 18 h after surgery. POTENTIAL RELEVANCE This neutrophilic inflammation coincides with the clinical time point at which POI is identified and may indicate that inflammatory pathways, rather than solely neurogenic pathways, are responsible for POI in the horse.}, number={4}, journal={EQUINE VETERINARY JOURNAL}, author={Little, D and Tomlinson, JE and Blikslager, AT}, year={2005}, month={Jul}, pages={329–335} } @article{moeser_haskell_shifflett_little_schultz_blikslager_2004, title={CIC-2 chloride secretion mediates prostaglandin-induced recovery of barrier function in ischemia-injured porcine ileum}, volume={127}, ISSN={["1528-0012"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-4444353665&partnerID=MN8TOARS}, DOI={10.1053/j.gastro.2004.06.004}, abstractNote={BACKGROUND & AIMS Ischemia results in the breakdown of the intestinal barrier, predisposing patients to sepsis and multiple organ failure. Prostaglandins play a critical role in mediating recovery of barrier function in ischemia-injured intestine through a mechanism involving stimulation of Cl - secretion. In the present study, we investigated the contributory role of individual Cl - channels in the recovery of barrier function in ischemia-injured porcine ileum. METHODS Ischemia-injured porcine ileal mucosa was mounted in Ussing chambers. Short-circuit current (Isc) and transepithelial resistance (TER) were measured in response to prostaglandin E 2 (PGE 2 ) and pharmacologic inhibitors of epithelial Cl - channels. Immunoassays were used to assess the expression and localization of ion channels. RESULTS Application of PGE 2 to ischemia-injured ileal mucosa stimulated increases in Isc, an indicator of Cl - secretion, that was followed by marked increases in TER, an indicator of barrier function recovery. In vitro studies revealed that although PGE 2 induced Cl - secretion via at least 3 distinct secretory pathways, recovery of barrier function was initiated by Cl - secretion via ClC-2 Cl - channels co-expressed with occludin and localized to tight junctions within restituting epithelium. Intravenous administration of furosemide to pigs subjected to 1 hour of ileal ischemia impaired recovery of barrier function, as evidenced by decreased TER and increased mucosal-to-serosal 3 H-mannitol flux after a 2-hour reperfusion/recovery period, confirming an important role for Cl - secretory pathways in vivo. CONCLUSIONS ClC-2-mediated intestinal Cl - secretion restores TER in ischemia-injured intestine. These data may provide the basis for targeted pharmacologic therapy for diseases associated with impaired barrier function.}, number={3}, journal={GASTROENTEROLOGY}, author={Moeser, AJ and Haskell, MM and Shifflett, DE and Little, D and Schultz, BD and Blikslager, AT}, year={2004}, month={Sep}, pages={802–815} } @article{little_flowers_hammerberg_gardner_2003, title={Management of drug-resistant cyathostominosis on a breeding farm in central North Carolina}, volume={35}, ISSN={["2042-3306"]}, DOI={10.2746/042516403776148264}, abstractNote={Summary}, number={3}, journal={EQUINE VETERINARY JOURNAL}, author={Little, D and Flowers, JR and Hammerberg, BH and Gardner, SY}, year={2003}, month={May}, pages={246–251} } @article{little_dean_young_mckane_martin_jones_blikslager_2003, title={PI3K signaling is required for prostaglandin-induced mucosal recovery in ischemia-injured porcine ileum}, volume={284}, ISSN={0193-1857 1522-1547}, url={http://dx.doi.org/10.1152/ajpgi.00121.2002}, DOI={10.1152/ajpgi.00121.2002}, abstractNote={ We have previously shown that PGE2 and PGI2 induce recovery of transepithelial resistance (TER) in ischemia-injured porcine ileal mucosa, associated with initial increases in Cl−secretion. We believe that the latter generates an osmotic gradient that stimulates resealing of tight junctions. Because of evidence implicating phosphatidylinositol 3-kinase (PI3K) in regulating tight junction assembly, we postulated that this signaling pathway is involved in PG-induced mucosal recovery. Porcine ileum was subjected to 45 min of ischemia, after which TER was monitored for a 180-min recovery period. Endogenous PG production was inhibited with indomethacin (5 μM). PGE2 (1 μM) and PGI2(1 μM) stimulated recovery of TER, which was inhibited by serosal application of the osmotic agent urea (300 mosmol/kgH2O). The PI3K inhibitor wortmannin (10 nM) blocked recovery of TER in response to PGs or mucosal urea. Immunofluorescence imaging of recovering epithelium revealed that PGs restored occludin and zonula occludens-1 distribution to interepithelial junctions, and this pattern was disrupted by pretreatment with wortmannin. These experiments suggest that PGs stimulate recovery of paracellular resistance via a mechanism involving transepithelial osmotic gradients and PI3K-dependent restoration of tight junction protein distribution. }, number={1}, journal={American Journal of Physiology-Gastrointestinal and Liver Physiology}, publisher={American Physiological Society}, author={Little, Dianne and Dean, Rebecca A. and Young, Karen M. and McKane, Shaun A. and Martin, Linda D. and Jones, Samuel L. and Blikslager, Anthony T.}, year={2003}, month={Jan}, pages={G46–G56} } @article{stanar_little_redding_jones_2002, title={Equine rounds - Case presentation: Idiopathic eosinophilic enteritis in a 10-week-old colt}, volume={24}, number={4}, journal={Compendium on Continuing Education for the Practicing Veterinarian}, author={Stanar, L. S. and Little, D. and Redding, W. R. and Jones, S. L.}, year={2002}, pages={342–344} } @article{little_blikslager_2002, title={Factors associated with development of ileal impaction in horses with surgical colic: 78 cases (1986-2000)}, volume={34}, ISSN={["2042-3306"]}, DOI={10.2746/042516402776117773}, abstractNote={Summary}, number={5}, journal={EQUINE VETERINARY JOURNAL}, author={Little, D and Blikslager, AT}, year={2002}, month={Jul}, pages={464–468} } @article{little_keene_bruton_smith_powell_jones_2002, title={Percutaneous retrieval of a jugular catheter fragment from the pulmonary artery of a foal}, volume={220}, ISSN={["0003-1488"]}, url={http://europepmc.org/abstract/med/12126133}, DOI={10.2460/javma.2002.220.212}, abstractNote={A 49-kg (107.8-lb) sexually intact male Arabian foal was evaluated at 3 days of age because of profuse watery diarrhea, anorexia, and signs of abdominal pain. Physical examination findings were unremarkable except for evidence of diarrhea. A catheter was placed in the right jugular vein for administration of antimicrobials and lactated Ringer's solution. The foal was discharged with instructions to the owner to continue antimicrobial administration and fluid therapy; at home, the owner inadvertently cut the catheter at the level of the hub during attempted removal, and the catheter fragment migrated distally in the jugular vein and subsequently lodged in the pulmonary artery. The foal was readmitted to the hospital for retrieval of the fragment, using a percutaneous retrieval technique. Catheter fragmentation is a well-recognized risk of catheterization in horses. Catheter fragments can be retrieved somewhat easily from the jugular vein; however, if the fragment migrates to the heart or pulmonary artery, imaging the fragment to locate and retrieve it can be difficult. Complications associated with catheter fragmentation include septicemia, endocarditis, lung abscesses, pulmonary embolism, dysrhythmias, cardiac perforation, pulmonary or caval thrombosis, and death. To our knowledge, this is the first report of successful retrieval of a catheter fragment from the pulmonary artery in a horse.}, number={2}, journal={JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION}, author={Little, D and Keene, BW and Bruton, C and Smith, LJ and Powell, S and Jones, SL}, year={2002}, month={Jan}, pages={212–214} } @article{blikslager_zimmel_young_campbell_little_argenzio_2002, title={Recovery of ischaemic injured porcine ileum: evidence for a contributory role of COX-1 and COX-2}, volume={50}, ISSN={0017-5749}, url={http://dx.doi.org/10.1136/gut.50.5.615}, DOI={10.1136/gut.50.5.615}, abstractNote={Background: We have previously shown that the non-selective cyclooxygenase (COX) inhibitor indomethacin retards recovery of intestinal barrier function in ischaemic injured porcine ileum. However, the relative role of COX-1 and COX-2 elaborated prostaglandins in this process is unclear. Aims: To assess the role of COX-1 and COX-2 elaborated prostaglandins in the recovery of intestinal barrier function by evaluating the effects of selective COX-1 and COX-2 inhibitors on mucosal recovery and eicosanoid production. Methods: Porcine ileal mucosa subjected to 45 minutes of ischaemia was mounted in Ussing chambers, and transepithelial electrical resistance was used as an indicator of mucosal recovery. Prostaglandins E1 and E2 (PGE) and 6-keto-PGF1α (the stable metabolite of prostaglandin I2 (PGI2)) were measured using ELISA. Thromboxane B2 (TXB2, the stable metabolite of TXA2) was measured as a likely indicator of COX-1 activity. Results: Ischaemic injured tissues recovered to control levels of resistance within three hours whereas tissues treated with indomethacin (5×10−6 M) failed to fully recover, associated with inhibition of eicosanoid production. Injured tissues treated with the selective COX-1 inhibitor SC-560 (5×10−6 M) or the COX-2 inhibitor NS-398 (5×10−6 M) recovered to control levels of resistance within three hours, associated with significant elevations of PGE and 6-keto-PGF1α compared with untreated tissues. However, SC-560 significantly inhibited TXB2 production whereas NS-398 had no effect on this eicosanoid, indicating differential actions of these inhibitors related to their COX selectivity. Conclusions: The results suggest that recovery of resistance is triggered by PGE and PGI2, which may be elaborated by either COX-1 or COX-2.}, number={5}, journal={Gut}, publisher={BMJ}, author={Blikslager, A.T. and Zimmel, D.N. and Young, K.M. and Campbell, N.B. and Little, D. and Argenzio, R.A.}, year={2002}, month={May}, pages={615–623} } @article{little_redding_blikslager_2001, title={Risk factors for reduced postoperative fecal output in horses: 37 cases (1997-1998)}, volume={218}, ISSN={["0003-1488"]}, DOI={10.2460/javma.2001.218.414}, abstractNote={Abstract}, number={3}, journal={JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION}, author={Little, D and Redding, WR and Blikslager, AT}, year={2001}, month={Feb}, pages={414–420} } @article{little_redding_spaulding_dupree_jones_2000, title={Unusual presentation of nutritional secondary hyperparathyroidism in a Paint colt}, volume={2}, DOI={10.1111/j.2042-3292.2000.tb00064.x}, abstractNote={Equine Veterinary EducationVolume 12, Issue 6 p. 297-302 Unusual presentation of nutritional secondary hyperparathyroidism in a Paint colt D. Little, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA.Search for more papers by this authorW. R. Redding, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA.Search for more papers by this authorK. A. Spaulding, Anatomy, Physiology and Radiology, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA.Search for more papers by this authorS. H. Dupree, Veterinary Teaching Hospital, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA.Search for more papers by this authorS. L. Jones, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA.Search for more papers by this author D. Little, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA.Search for more papers by this authorW. R. Redding, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA.Search for more papers by this authorK. A. Spaulding, Anatomy, Physiology and Radiology, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA.Search for more papers by this authorS. H. Dupree, Veterinary Teaching Hospital, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA.Search for more papers by this authorS. L. Jones, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA.Search for more papers by this author First published: 05 January 2010 https://doi.org/10.1111/j.2042-3292.2000.tb00064.xCitations: 3AboutPDF ToolsExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinked InRedditWechat Citing Literature Volume12, Issue6December 2000Pages 297-302 RelatedInformation}, number={6}, journal={Equine Veterinary Education}, author={Little, D. and Redding, W.R. and Spaulding, K.A. and Dupree, S.H. and Jones, Sam}, year={2000}, pages={388–394} }