Dongming Ma

Works (7)

Updated: July 5th, 2023 15:39

2021 journal article

A de novo regulation design shows an effectiveness in altering plant secondary metabolism

JOURNAL OF ADVANCED RESEARCH, 37, 43–60.

By: M. Li n, X. He n, C. La Hovary n, Y. Zhu n, Y. Dong n, S. Liu  n, H. Xing  n, Y. Liu n ...

author keywords: Arabidopsis; Alkaloid; Anthocyanin; Molecular tools; Tobacco; Transcription factor
MeSH headings : Arabidopsis / genetics; Arabidopsis Proteins / genetics; Arabidopsis Proteins / metabolism; Gene Expression Regulation, Plant; Nicotine / metabolism; Pancreatitis-Associated Proteins / genetics; Pancreatitis-Associated Proteins / metabolism; Secondary Metabolism / genetics
TL;DR: G-boxes, MREs, and two TF types are appropriate molecular tools for a De Novo regulation design to create a novel distant-pathway cross regulation for altering plant secondary metabolism. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: January 26, 2022

2019 journal article

A polyketide synthase gene cluster associated with the sexual reproductive cycle of the banana pathogen, Pseudocercospora fijiensis

PLOS ONE, 14(7), e0220319.

By: R. Noar n, E. Thomas n , D. Xie n , M. Carter  n, D. Ma n & M. Daub n

Ed(s): O. Lespinet

MeSH headings : Ascomycota / enzymology; Ascomycota / genetics; Ascomycota / pathogenicity; Ascomycota / physiology; Fungal Proteins / genetics; Multigene Family; Musa / microbiology; Neurospora crassa / enzymology; Neurospora crassa / genetics; Phylogeny; Plant Diseases / genetics; Plant Diseases / microbiology; Plant Leaves / microbiology; Polyketide Synthases / genetics; Reproduction / genetics; Sequence Homology; Sordariales / enzymology; Sordariales / genetics
TL;DR: This is the first report of a polyketide synthase pathway associated with spermagonia associated with P. fijiensis, and it is shown that PKS8-4 is more similar than Hybrid8-3 to PKS4. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: September 30, 2019

2019 journal article

Untargeted Metabolomics of Nicotiana tabacum Grown in United States and India Characterizes the Association of Plant Metabolomes With Natural Climate and Geography

Frontiers in Plant Science, 10.

By: D. Ma n, S. Gandra*, R. Manoharlal *, C. La Hovary n & D. Xie n 

author keywords: climate change; continent; geography; metabolomics; nicotine; tobacco; non-polar metabolite; polar metabolite
TL;DR: Comparison revealed that nicotine levels were affected by weather conditions, nevertheless, its trend in leaves was independent of two geographical locations and weather changes, suggesting that climate and geographical variation significantly differentiated the tobacco metabolism. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
13. Climate Action (Web of Science)
14. Life Below Water (Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: November 25, 2019

2017 journal article

Overexpression and Suppression of Artemisia annua 4-Hydroxy-3-Methylbut-2-enyl Diphosphate Reductase 1 Gene (AaHDR1) Differentially Regulate Artemisinin and Terpenoid Biosynthesis

FRONTIERS IN PLANT SCIENCE, 8.

By: D. Ma n, G. Li n, Y. Zhu n & D. Xie n 

author keywords: Artemisia annua; artemisinin; arteannuin B; 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase; methylerythritol phosphate pathway; terpene
TL;DR: The overexpression and suppression of AaHDR1 protein level in plastids differentially affect artemisinin and other terpenoid biosynthesis, and alter non-polar metabolite profiles of A. annua. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Overexpression of a type-I isopentenyl pyrophosphate isomerase of Artemisia annua in the cytosol leads to high arteannuinB production and artemisinin increase

Plant Journal, 91(3), 466–479.

By: D. Ma n, G. Li n, F. Alejos-Gonzalez n, Y. Zhu n, Z. Xue *, A. Wang *, H. Zhang *, X. Li * ...

MeSH headings : Artemisia annua / enzymology; Artemisia annua / genetics; Artemisia annua / metabolism; Artemisinins / metabolism; Carbon-Carbon Double Bond Isomerases / genetics; Carbon-Carbon Double Bond Isomerases / metabolism; Cytosol / enzymology; Cytosol / metabolism; Hemiterpenes; Plant Proteins / genetics; Plant Proteins / metabolism; Plants, Genetically Modified / enzymology; Plants, Genetically Modified / genetics; Plants, Genetically Modified / metabolism
TL;DR: Evidence is provided that overexpression of AaIPPI1 in the cytosol can lead to metabolic alterations of terpenoid biosynthesis, and it is shown that transgenic plants have the potential to yield high production levels of arteannuin B as a new precursor source for artemisinin. (via Semantic Scholar)
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Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2016 article

Artemisinin biosynthesis in Artemisia annua and metabolic engineering: questions, challenges, and perspectives

Xie, D.-Y., Ma, D.-M., Judd, R., & Jones, A. L. (2016, December). PHYTOCHEMISTRY REVIEWS, Vol. 15, pp. 1093–1114.

By: D. Xie n , D. Ma n, R. Judd n & A. Jones n

author keywords: Artemisia annua; Artemisinin; Genetics; Malaria; Metabolic profiling; Sesquiterpenoid; Terpenoid
TL;DR: This work focuses on reviewing progresses achieved in understanding biosynthetic pathway, genetic breeding, metabolic engineering, and synthetic biology, and discusses multiple fundamental questions and challenges of artemisinin biosynthesis. (via Semantic Scholar)
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2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 journal article

A Genome-Wide Scenario of Terpene Pathways in Self-pollinated Artemisia annua

MOLECULAR PLANT, 8(11), 1580–1598.

By: D. Ma n, Z. Wang  n, L. Wang *, F. Alejos-Gonzales n, M. Sun * & D. Xie n 

author keywords: Artemisia annua; artemisinin; terpene; metabolic profiling; pyrosequencing
MeSH headings : Artemisia annua / genetics; Artemisia annua / metabolism; Artemisinins / metabolism; Gas Chromatography-Mass Spectrometry; Gene Expression Profiling; Genes, Plant; Metabolomics; Pollination / genetics; Self-Fertilization / genetics; Terpenes / metabolism
TL;DR: An integrated approach combining metabolomics, transcriptomics, and gene function analyses was used to characterize gene-to-terpene and terpene pathway scenarios in a self-pollinating variety of Artemisia annua, identifying 47 genes that mapped to the artemisinin, non-amorphadiene sesquiterpene, monoterpenes, triterpenes and mevalonate pathways. (via Semantic Scholar)
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15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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