Works (2)
Updated: April 4th, 2024 05:35
2023 journal article
Epigenetic function during heroin self-administration controls future relapse-associated behavior in a cell type-specific manner
Proceedings of the National Academy of Sciences, 120(7).
MeSH headings : Mice; Animals; Mice, Transgenic; Heroin / metabolism; Heroin / pharmacology; Cocaine / pharmacology; Reinforcement, Psychology; Drug-Seeking Behavior / physiology; Epigenesis, Genetic; Nucleus Accumbens / physiology; Self Administration
TL;DR:
It is discovered thatHDAC5 regulates a genetic program linked to neuron excitability, and it reduces the firing rate of critical neurons in a major brain-reward region, the nucleus accumbens, suggesting that HDAC5 reduces future relapse-associated behavior by limiting neuronal excitability during active opioid use.
(via Semantic Scholar)
doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: May 2, 2023
2022 journal article
A Subset of Nucleus Accumbens Neurons Receiving Dense and Functional Prelimbic Cortical Input Are Required for Cocaine Seeking
Frontiers in Cellular Neuroscience, 16.
TL;DR:
A unique subpopulation of nucleus accumbens neurons that receive dense prelimbic cortical input represents a novel target for addiction therapeutics revealed by anterograde targeting to interrogate functional circuits imbedded within a known network.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: May 2, 2023
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