David Dorris

Works (15)

Updated: April 5th, 2024 08:31

2023 journal article

Sex steroid hormones, the estrous cycle, and rapid modulation of glutamatergic synapse properties in the striatal brain regions with a focus on 17β -estradiol and the nucleus accumbens

STEROIDS, 201.

By: S. Proano n, C. Miller n, A. Krentzel n, D. Dorris n & J. Meitzen n 

author keywords: Estradiol; Sex differences; Estrous cycle; Nucleus accumbens; Estrogen receptors
TL;DR: There is strong evidence regarding estradiol action upon glutamatergic synapse function in female NAcs MSNs and call for more research regarding other hormones and striatal regions. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 8, 2024

2022 journal article

The estrous cycle and 17β‐estradiol modulate the electrophysiological properties of rat nucleus accumbens core medium spiny neurons

Journal of Neuroendocrinology, 34(6).

By: A. Krentzel n, S. Proaño*, D. Dorris n, B. Setzer * & J. Meitzen n 

author keywords: estradiol; estrogen receptors; estrous cycle; nucleus accumbens; sex differences
MeSH headings : Animals; Estradiol / pharmacology; Estrous Cycle; Female; Male; Mammals; Neurons / physiology; Nucleus Accumbens / physiology; Rats; Sex Characteristics
TL;DR: Recent insights demonstrate the strong impact of sex‐specific estradiol action upon nucleus accumbens core neuron electrophysiology, which mirror the natural changes seen across estrous cycle phases. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: April 18, 2022

2021 journal article

FireMaster (R) 550 (FM 550) exposure during the perinatal period impacts partner preference behavior and nucleus accumbens core medium spiny neuron electrophysiology in adult male and female prairie voles, Microtus ochrogaster

HORMONES AND BEHAVIOR, 134.

By: A. Krentzel n, L. Kimble n, D. Dorris n, B. Horman n, J. Meitzen n  & H. Patisaul n 

author keywords: Vole; Electrophysiology; Nucleus accumbens; Flame  retardants; Endocrine disruptors; Neurodevelopment; Endocrine disrupting chemical
MeSH headings : Animals; Arvicolinae; Electrophysiology; Female; Grassland; Male; Neurons; Nucleus Accumbens; Organophosphates; Pair Bond; Polybrominated Biphenyls; Pregnancy; Social Behavior; Zebrafish
TL;DR: The hypothesis that developmental exposure to FM 550 impacts attachment behaviors is supported and a novel FM 550 effect on neural electrophysiology is demonstrated. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: September 7, 2021

2020 review

Sex bias and omission in neuroscience research is influenced by research model and journal, but not reported NIH funding

[Review of ]. FRONTIERS IN NEUROENDOCRINOLOGY, 57.

By: G. Mamlouk n, D. Dorris n, L. Barrett* & J. Meitzen n 

author keywords: Sex bias; Sex omission; Sex reporting; Sex difference; Women's health; Male; Female; Neuroscience
MeSH headings : Animals; Biomedical Research / economics; Biomedical Research / statistics & numerical data; Disease Models, Animal; Female; Humans; Male; National Institutes of Health (U.S.); Neurosciences / statistics & numerical data; Research Support as Topic; Serial Publications / statistics & numerical data; Sexism / statistics & numerical data; United States
TL;DR: The status of sex bias and omission in neuroscience research published across six different journals in 2017 was analyzed and differed across research models, but not by reported NIH funding status. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
4. Quality Education (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 1, 2020

2019 journal article

Electrophysiological Properties of Medium Spiny Neuron Subtypes in the Caudate-Putamen of Prepubertal Male and Female Drd1a-tdTomato Line 6 BAC Transgenic Mice

ENEURO, 6(2).

By: J. Willett n, J. Cao*, D. Dorris*, A. Johnson *, L. Ginnari* & J. Meitzen n 

author keywords: caudate putamen; electrophysiology; intrinsic excitability; medium spiny neurons; rodent; sex differences
MeSH headings : Animals; Corpus Striatum / cytology; Corpus Striatum / physiology; Electrophysiology; Female; Male; Mice; Mice, Transgenic; Neurons / cytology; Neurons / physiology; Organ Culture Techniques; Sex Characteristics; Synaptic Potentials / physiology
TL;DR: A comprehensive evaluation of mouse caudate-putamen MSN subtype electrophysiological properties across females and males is provided, both confirming and extending previous studies. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: May 28, 2019

2019 journal article

The estrous cycle modulates rat caudate-putamen medium spiny neuron physiology

EUROPEAN JOURNAL OF NEUROSCIENCE, 52(1), 2737–2755.

By: J. Willett n, J. Cao n, A. Johnson  n, O. Patel n, D. Dorris n & J. Meitzen n 

author keywords: caudate-putamen; electrophysiology; estrous cycle; excitability; medium spiny neuron; sex differences
MeSH headings : Action Potentials; Animals; Estrous Cycle; Female; Male; Neurons; Nucleus Accumbens; Putamen; Rats
TL;DR: Recordings indicate that female caudate–putamen MSNs are sensitive to the estrous cycle, and the importance of considering neuroendocrine state in studies of neuron physiology is considered. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 12, 2019

2018 journal article

Electrophysiological properties of medium spiny neurons in the nucleus accumbens core of prepubertal male and female Drd1a-tdTomato line 6 BAC transgenic mice

JOURNAL OF NEUROPHYSIOLOGY, 120(4), 1712–1727.

By: J. Cao n, D. Dorris n & J. Meitzen n 

author keywords: medium spiny neuron; mice; nucleus accumbens; sex; ventral striatum
MeSH headings : Action Potentials; Animals; Excitatory Postsynaptic Potentials; Female; Male; Mice; Mice, Inbred C57BL; Miniature Postsynaptic Potentials; Neurons / physiology; Nucleus Accumbens / growth & development; Nucleus Accumbens / physiology; Sex Factors
TL;DR: This research provides the most comprehensive assessment of medium spiny neuron subtype electrophysiological properties to date in a critical brain region, the nucleus accumbens core, and represents the first evaluation of whether mouse medium sp Tiny neuron sub type electrophYSiological properties differ by sex. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: December 10, 2018

2018 journal article

Estrous cycle-induced sex differences in medium spiny neuron excitatory synaptic transmission and intrinsic excitability in adult rat nucleus accumbens core

JOURNAL OF NEUROPHYSIOLOGY, 120(3), 1356–1373.

By: S. Proano n, H. Morris n, L. Kunz n, D. Dorris n & J. Meitzen n 

author keywords: estrous cycle; excitability; medium spiny neurons; nucleus accumbens; sex steroid hormones
MeSH headings : Action Potentials; Animals; Castration; Estrous Cycle; Excitatory Postsynaptic Potentials; Female; Male; Neurons / physiology; Nucleus Accumbens / physiology; Rats, Sprague-Dawley; Sex Characteristics
TL;DR: It is the first demonstration that medium spiny neuron electrophysiological properties change across adult female hormone cycle phases in any striatal region and indicates that adultFemale hormone cycles are an important factor for neurophysiology. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 5, 2018

2018 review

Sex Differences in Medium Spiny neuron excitability and Glutamatergic Synaptic input: Heterogeneity Across Striatal Regions and evidence for Estradiol-Dependent Sexual Differentiation

[Review of ]. FRONTIERS IN ENDOCRINOLOGY, 9.

By: J. Cao n, J. Willett n, D. Dorris n & J. Meitzen n 

author keywords: sex; estradiol; hormones; striatum; medium spiny neuron; nucleus accumbens; caudate-putamen; electrophysiology
TL;DR: Sex differences in rat MSN glutamatergic synaptic input and intrinsic excitability across striatal regions are reviewed, including evidence for estradiol-mediated sexual differentiation in the nucleus AcbC. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Problems and Progress regarding Sex Bias and Omission in Neuroscience Research

ENEURO, 4(6).

By: T. Will n, S. Proano n, A. Thomas n, L. Kunz n, K. Thompson n, L. Ginnari n, C. Jones n, S. Lucas n ...

author keywords: Animal models; journals; neuroscience; sex bias; sex omission
MeSH headings : Animals; Female; Male; Mice; Neurosciences; Rats; Sexism / statistics & numerical data; Sexism / trends
TL;DR: The largest-ever number of neuroscience articles for sex bias and omission is analyzed: 6636 articles using mice or rats in 6 journals published from 2010 to 2014, finding sex bias remains present and sex omission is declining, as increasing numbers of articles report sex. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
4. Quality Education (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Neonatal Masculinization Blocks Increased Excitatory Synaptic Input in Female Rat Nucleus Accumbens Core

ENDOCRINOLOGY, 157(8), 3181–3196.

By: J. Cao n, D. Dorris n & J. Meitzen n 

MeSH headings : Animals; Animals, Newborn; Estradiol / pharmacology; Excitatory Postsynaptic Potentials / drug effects; Excitatory Postsynaptic Potentials / physiology; Female; Feminization / chemically induced; Feminization / pathology; Feminization / physiopathology; Male; Nucleus Accumbens / cytology; Nucleus Accumbens / drug effects; Nucleus Accumbens / physiology; Rats; Rats, Sprague-Dawley; Sex Characteristics; Sexual Maturation / drug effects; Sexual Maturation / physiology; Synaptic Transmission / drug effects; Synaptic Transmission / physiology
TL;DR: It is concluded that excitatory synaptic input onto AcbC MSNs is organized long before adulthood via steroid sex hormone action, providing new insight into a mechanism by which sex differences in motivated behavior and other AbcC functions may be generated or compromised. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

No Evidence for Sex Differences in the Electrophysiological Properties and Excitatory Synaptic Input onto Nucleus Accumbens Shell Medium Spiny Neurons

ENEURO, 3(1).

By: J. Willett n, T. Will n, C. Hauser n, D. Dorris n, J. Cao n & J. Meitzen n 

author keywords: genetic sex; intrinsic electrophysiological properties; male and female rats; medium spiny neuron; mEPSC; striatum
MeSH headings : Action Potentials; Animals; Excitatory Postsynaptic Potentials; Female; Interneurons / physiology; Male; Membrane Potentials; Miniature Postsynaptic Potentials; Nucleus Accumbens / physiology; Rats; Rats, Sprague-Dawley; Sex Characteristics
TL;DR: Overall, it appears that sex differences in striatal function, including motivated behavior and reward, are likely mediated by other factors and striatal regions. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Genetic sex and the volumes of the caudate-putamen, nucleus accumbens core and shell: original data and a review

BRAIN STRUCTURE & FUNCTION, 221(8), 4257–4267.

By: J. Wong n, J. Cao n, D. Dorris n & J. Meitzen n 

author keywords: Striatum; Caudate-putamen; Dorsal striatum; Ventral striatum; Volume; Nucleus accumbens; Sex; Hemisphere; Lateralization
MeSH headings : Animals; Caudate Nucleus / anatomy & histology; Caudate Nucleus / physiology; Female; Male; Nucleus Accumbens / anatomy & histology; Nucleus Accumbens / physiology; Preoptic Area / anatomy & histology; Preoptic Area / physiology; Putamen / anatomy & histology; Putamen / physiology; Rats; Rats, Sprague-Dawley; Sex Characteristics
TL;DR: Findings complement previous reports of lateralized nucleus accumbens volume in humans, and suggest that this may possibly be driven via hemispheric differences in nucleus Accumbens core volume. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

An aerator for brain slice experiments in individual cell culture plate wells

JOURNAL OF NEUROSCIENCE METHODS, 238, 1–10.

By: D. Dorris n, C. Hauser n, C. Minnehan n & J. Meitzen n 

author keywords: Brain slices; Aerator; Bubbler; 24-Well culture plate; Oxygenation; Dorsal striatum; beta-Adrenergic receptor; Caudate putamen
MeSH headings : Animals; Brain / drug effects; Brain / physiology; Cell Culture Techniques / instrumentation; Equipment Design; G-Protein-Coupled Receptor Kinase 2 / metabolism; Gene Expression / drug effects; Gene Expression / physiology; Immunohistochemistry; Neurons / drug effects; Neurons / physiology; Organ Culture Techniques / instrumentation; Oxygen / administration & dosage; Patch-Clamp Techniques / instrumentation; RNA, Messenger / metabolism; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Spectrum Analysis
TL;DR: Key differences include enhanced control over gas delivery to individual wells containing brain slices, decreased necessary volume, a sample restraint to reduce movement artifacts, the potential to be sterilized, the avoidance of materials that absorb water and small biological molecules, minimal production costs, and increased experimental throughput. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Intrinsic excitability varies by sex in prepubertal striatal medium spiny neurons

JOURNAL OF NEUROPHYSIOLOGY, 113(3), 720–729.

By: D. Dorris n, J. Cao n, J. Willett n, C. Hauser n & J. Meitzen n 

author keywords: intrinsic excitability; sex differences; medium spiny neuron; dorsal striatum; mEPSC
MeSH headings : Action Potentials; Animals; Corpus Striatum / cytology; Corpus Striatum / growth & development; Corpus Striatum / physiology; Female; Male; Neurons / physiology; Rats; Rats, Sprague-Dawley; Sex Factors
TL;DR: It is indicated that MSN excitability is increased in prepubertal females compared with males, providing a new mechanism that potentially contributes to generating sex differences in striatal-mediated processes. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.

Certain data included herein are derived from the Web of Science© and InCites© (2025) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.