Dragan Milenkovic

Plant Polyphenols as Heart’s Best Friends: From Health Properties, to Cellular Effects, to Molecular Mechanisms of Action

International Journal of Molecular Sciences.

<i>Juniperus oxycedrus</i> L. fruit, leaves, and essential oil: a systematic literature review on bioactive compounds, pharmacological properties and toxicology

Moumou, M., Mokhtari, I., Tayebi, A., Milenkovic, D., Amrani, S., & Harnafi, H. (2024, December 28). PHYTOCHEMISTRY REVIEWS, Vol. 12.

Effects of <i>Cynara scolymus</i> L. Bract Extract on Lipid Metabolism Disorders Through Modulation of HMG-CoA Reductase, Apo A-1, PCSK-9, p-AMPK, SREBP-2, and CYP2E1 Expression

METABOLITES, 14(12).

Gene expression analysis reveals diabetes-related gene signatures

Human Genomics.

How cy pres promotes transdisciplinary convergence science: an academic health center for women’s cardiovascular and brain health

Journal of Clinical and Translational Science.

Integrated Analysis of Genomic and Genome-Wide Association Studies Identified Candidate Genes for Nutrigenetic Studies in Flavonoids and Vascular Health: Path to Precision Nutrition for (Poly)phenols

Nutrients.

Lemon Flavonoid Extract Eriomin Improves Pro/Antioxidant Status and Interferes with Cholesterol Metabolism without Affecting Serum Cholesterol Levels in Aged Rats

International Journal of Molecular Sciences.

Lemon extract reduces the hepatic oxidative stress and persulfidation levels by upregulating the Nrf2 and Trx1 expression in old rats

BioFactors.

Plasma proteome profiling reveals molecular mechanisms underlying the effects of daily consumption of ‘Bahia’ and ‘Cara Cara’ orange juices

Food &Amp; Function.

Single Nuclei Transcriptomics Reveals Obesity-Induced Endothelial and Neurovascular Dysfunction: Implications for Cognitive Decline

International Journal of Molecular Sciences.

Supplemental analysis.docx

Table S1.xls

Table S2.xlsx

The Brain Metabolome Is Modified by Obesity in a Sex-Dependent Manner

International Journal of Molecular Sciences.

Citrus flavanone metabolites significantly modulate global proteomic profile in pancreatic β-cells under high-glucose-induced metabolic stress

Biochimica Et Biophysica Acta (BBA) - Proteins and Proteomics, 1871(3), 140898.

Editorial: Plant food bioactives, genomics, and health effects

Frontiers in Nutrition.

Immature carob pods extract and its fractions prevent lipid metabolism disorders and lipoprotein-rich plasma oxidation in mice: A phytochemical and pharmacological study

Journal of Ethnopharmacology.

Integrated Analysis of Genomic and GWAS Data to Identify Candidate Genes for Genetic Studies in Flavonoids and Vascular Health: Path to Precise Nutrition for (Poly)phenols

Proceedings.

Interaction between APOE, APOA1, and LPL Gene Polymorphisms and Variability in Changes in Lipid and Blood Pressure following Orange Juice Intake: A Pilot Study

Molecular Nutrition &Amp; Food Research.

Lemon flavonoids nutraceutical (Eriomin®) attenuates prediabetes intestinal dysbiosis: A double‐blind randomized controlled trial

Food Science &Amp; Nutrition.

Loquat fruit peel extract regulates lipid metabolism and liver oxidative stress in mice: In vivo and in silico approaches

Journal of Ethnopharmacology.

Polyphenol-rich extract from loquat fruit peel prevents hyperlipidemia and hepato-nephrotoxicity in mice: <i>in vivo</i> study and <i>in silico</i> prediction of possible mechanisms involving identified polyphenols and/or their circulating metabolites

Food &Amp; Function.

Sex Modifies the Impact of Type 2 Diabetes Mellitus on the Murine Whole Brain Metabolome

Metabolites.

Sex-Specific Response of the Brain Free Oxylipin Profile to Soluble Epoxide Hydrolase Inhibition

Nutrients.

Single nuclei transcriptomics in diabetic mice reveals altered brain hippocampal endothelial cell function, permeability, and behavior

Biochimica Et Biophysica Acta (BBA) - Molecular Basis of Disease.

(−)-Epicatechin exerts positive effects on anxiety in high fat diet-induced obese mice through multi-genomic modifications in the hippocampus

Food &Amp; Function, 13(20), 10623–10641.

A high sucrose diet modifies brain oxylipins in a sex-dependent manner

Prostaglandins, Leukotrienes and Essential Fatty Acids, 186, 102506.

Anthocyanin-rich extract from black beans exerts anti-diabetic effects in rats through a multi-genomic mode of action in adipose tissue

Frontiers in Nutrition, 9.

Association between Single Nucleotide Polymorphisms of SULT1A1, SULT1C4, ABCC2 and Phase II Flavanone Metabolites Excretion after Orange Juice Intake

Nutrients.

Effect of <i>Passiflora setacea</i> juice and its phenolic metabolites on insulin resistance markers in overweight individuals and on microglial cell activity

Food &Amp; Function, 13(12), 6498–6509.

Flavan-3-ols and Cardiometabolic Health: First Ever Dietary Bioactive Guideline

Advances in Nutrition, 13(6), 2070–2083.

Flavanol Consumption in Healthy Men Preserves Integrity of Immunological‐Endothelial Barrier Cell Functions: Nutri(epi)genomic Analysis

Molecular Nutrition &Amp; Food Research, 66(21), 2100991.

Grapefruit Juice Flavanones Modulate the Expression of Genes Regulating Inflammation, Cell Interactions and Vascular Function in Peripheral Blood Mononuclear Cells of Postmenopausal Women

Frontiers in Nutrition, 9.

High Glycemia and Soluble Epoxide Hydrolase in Females: Differential Multiomics in Murine Brain Microvasculature

International Journal of Molecular Sciences, 23(21), 13044.

In vitro, in vivo and in silico evaluation of the anti-inflammatory potential of Hyssopus officinalis L. subsp. aristatus (Godr.) Nyman (Lamiaceae)

Journal of Ethnopharmacology, 293, 115201.

Mechanistic insights into dietary (poly)phenols and vascular dysfunction-related diseases using multi-omics and integrative approaches: Machine learning as a next challenge in nutrition research

Molecular Aspects of Medicine, 89, 101101.

Molecular mechanisms underlying hypertensive effect of fructose and the preventive properties of inulin – Global transcriptomic analysis in rat aorta

Nutrition, Metabolism and Cardiovascular Diseases, 33(2), 441–456.

Multigenomic modifications in human circulating immune cells in response to consumption of polyphenol-rich extract of yerba mate (<i>Ilex paraguariensis A. St.-Hil.</i>) are suggestive of cardiometabolic protective effects

British Journal of Nutrition, 129(2), 185–205.

Structurally related (−)-epicatechin metabolites and gut microbiota derived metabolites exert genomic modifications via VEGF signaling pathways in brain microvascular endothelial cells under lipotoxic conditions: Integrated multi-omic study

Journal of Proteomics, 263, 104603.

Systematic analysis of nutrigenomic effects of polyphenols related to cardiometabolic health in humans – Evidence from untargeted mRNA and miRNA studies

Ageing Research Reviews, 79, 101649.

Targeting the gut to prevent and counteract metabolic disorders and pathologies during aging

Critical Reviews in Food Science and Nutrition, 6, 1–26.

The Brain’s Microvascular Response to High Glycemia and to the Inhibition of Soluble Epoxide Hydrolase Is Sexually Dimorphic

Nutrients, 14(17), 3451.

Underlying evidence for the health benefits of fermented foods in humans.

Food & Function.

Brazilian passion fruit as a new healthy food: from its composition to health properties and mechanisms of action

Food &Amp; Function, 12(22), 11106–11120.

Circulating (Poly)phenol Metabolites: Neuroprotection in a 3D Cell Model of Parkinson's Disease

Molecular Nutrition &Amp; Food Research, 66(21), 2100959.

Effect of probiotic, prebiotic, and synbiotic on the gut microbiota of autistic children using an in vitro gut microbiome model

Food Research International, 149, 110657.

Evaluating the role of orange juice, HESPERidin in vascular HEALTH benefits (HESPER-HEALTH study): protocol for a randomised controlled trial

BMJ Open, 11(11), e053321.

Inhibition of Soluble Epoxide Hydrolase Is Protective against the Multiomic Effects of a High Glycemic Diet on Brain Microvascular Inflammation and Cognitive Dysfunction

Nutrients, 13(11), 3913.

Inhibitory activity of quercetin, its metabolite, and standard antiviral drugs towards enzymes essential for SARS-CoV-2: the role of acid–base equilibria

RSC Advances, 11(5), 2838–2847.

Integrated Multi-Omic Analyses of the Genomic Modifications by Gut Microbiome-Derived Metabolites of Epicatechin, 5-(4′-Hydroxyphenyl)-γ-Valerolactone, in TNFalpha-Stimulated Primary Human Brain Microvascular Endothelial Cells

Frontiers in Neuroscience, 15.

Molecular Determinants of the Cardiometabolic Improvements of Dietary Flavanols Identified by an Integrative Analysis of Nutrigenomic Data from a Systematic Review of Animal Studies

Molecular Nutrition &Amp; Food Research, 65(16), 2100227.

Polyphenols Could Prevent SARS-CoV-2 Infection by Modulating the Expression of miRNAs in the Host Cells

Aging and Disease, 12(5), 1169.

Soy isoflavone-caused shunting of the corticosteroidogenesis pathways in andropausal subjects: Top-down impulse for the optimal supplementation design

Medical Hypotheses, 148, 110516.

Systematic Bioinformatic Analyses of Nutrigenomic Modifications by Polyphenols Associated with Cardiometabolic Health in Humans—Evidence from Targeted Nutrigenomic Studies

Nutrients, 13(7), 2326.

Acute Effects of the Consumption of Passiflora setacea Juice on Metabolic Risk Factors and Gene Expression Profile in Humans

Nutrients, 12(4), 1104.

Alterations of aorta intima and media transcriptome in swine fed high-fat diet over 1-year follow-up period and of the switch to normal diet

Nutrition, Metabolism and Cardiovascular Diseases, 30(7), 1201–1215.

Citrus Flavanones Upregulate Thyrotroph Sirt1 and Differently Affect Thyroid Nrf2 Expressions in Old-Aged Wistar Rats

Journal of Agricultural and Food Chemistry, 68(31), 8242–8254.

Citrus flavanone metabolites protect pancreatic-β cells under oxidative stress induced by cholesterol

Food &Amp; Function, 11(10), 8612–8624.

Clinical utility of brain-derived neurotrophic factor as a biomarker with left ventricular echocardiographic indices for potential diagnosis of coronary artery disease

Scientific Reports, 10(1).

Effects of the apple matrix on the postprandial bioavailability of flavan-3-ols and nutrigenomic response of apple polyphenols in minipigs challenged with a high fat meal

Food &Amp; Function, 11(6), 5077–5090.

Impact of Epicatechin on the Procoagulant Activities of Microparticles

Nutrients, 12(10), 2935.

Impact of epicatechin on fibrin clot structure

European Journal of Pharmacology, 893, 173830.

In silico analysis of antidiabetic potential of phenolic compounds from blue corn (Zea mays L.) and black bean (Phaseolus vulgaris L.)

Heliyon, 6(3), e03632.

Lipotoxic Injury Differentially Regulates Brain Microvascular Gene Expression in Male Mice

Nutrients, 12(6), 1771.

Microbiota modulation and effects on metabolic biomarkers by orange juice: a controlled clinical trial

Food and Function, 11(2), 1599–1610.

Phenolic-Rich Extract from Almond (Prunus dulcis ) Hulls Improves Lipid Metabolism in Triton WR-1339 and High-Fat Diet-Induced Hyperlipidemic Mice and Prevents Lipoprotein Oxidation: A Comparison with Fenofibrate and Butylated Hydroxyanisole

Preventive Nutrition and Food Science, 25(3), 254–262.

Sex-Dependent Molecular Mechanisms of Lipotoxic Injury in Brain Microvasculature: Implications for Dementia

International Journal of Molecular Sciences, 21(21), 8146.

Systematic bioinformatic analysis of nutrigenomic data of flavanols in cell models of cardiometabolic disease

Food &Amp; Function, 11(6), 5040–5064.

Why interindividual variation in response to consumption of plant food bioactives matters for future personalised nutrition

Proceedings of the Nutrition Society, 79(2), 225–235.

(−)-Epicatechin metabolites promote vascular health through epigenetic reprogramming of endothelial-immune cell signaling and reversing systemic low-grade inflammation

Biochemical Pharmacology, 173, 113699.

Anthocyanins: From Sources and Bioavailability to Cardiovascular-Health Benefits and Molecular Mechanisms of Action

Journal of Agricultural and Food Chemistry, 67(7), 1771–1783.

Circulating Anthocyanin Metabolites Mediate Vascular Benefits of Blueberries: Insights from Randomized Controlled Trials, Metabolomics, and Nutrigenomics

Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 74(7), 967–976.

Epicatechin influences primary hemostasis, coagulation and fibrinolysis

Food and Function, 10(11), 7291–7298.

Factors influencing the cardiometabolic response to (poly)phenols and phytosterols: a review of the COST Action POSITIVe activities

European Journal of Nutrition, 58, 37–47.

Nutritional regulation of mammary miRNome: Implications for human studies

In Handbook of Nutrition, Diet, and Epigenetics (Vol. 3, pp. 1495–1511).

Polyphenols in human nutrition: From the in vitro antioxidant capacity to the beneficial effects on cardiometabolic health and related inter-individual variability - An overview and perspective

British Journal of Nutrition, 123(3), 241–254.

Targeting the delivery of dietary plant bioactives to those who would benefit most: from science to practical applications

European Journal of Nutrition, 58, 65–73.

The Western Diet Regulates Hippocampal Microvascular Gene Expression: An Integrated Genomic Analyses in Female Mice

Scientific Reports, 9(1).

A systems biology network analysis of nutri(epi)genomic changes in endothelial cells exposed to epicatechin metabolites

Scientific Reports, 8(1).