David Michael Reif

Also known as: David M. Reif

https://orcid.org/0000-0001-7815-6767

predictive toxicology, data science, environmental health science, genetics, bioinformatics, NAMs, risk assessment, Artificial Intelligence / Machine Learning (AI / ML)

Works (158)

Updated: February 20th, 2024 12:20

2024 journal article

Guided optimization of ToxPi model weights using a Semi-Automated approach

COMPUTATIONAL TOXICOLOGY, 29.

By: J. Fleming n, J. House*, J. Chappel n, A. Motsinger-Reif* & D. Reif*

co-author countries: United States of America 🇺🇸
author keywords: Machine learning; Feature weighting; Exposure assessment; Chemical toxicity; Ordinal regression; Genetic algorithm
Sources: Web Of Science, ORCID
Added: January 16, 2024

2023 article

Aggregated Molecular Phenotype Scores: Enhancing Assessment and Visualization of Mass Spectrometry Imaging Data for Tissue-Based Diagnostics

Chappel, J. R., King, M. E., Fleming, J., Eberlin, L. S., Reif, D. M., & Baker, E. S. (2023, August 14). ANALYTICAL CHEMISTRY, Vol. 8.

By: J. Chappel n, M. King*, J. Fleming n, L. Eberlin*, D. Reif* & E. Baker*

co-author countries: United States of America 🇺🇸
Sources: Web Of Science, ORCID
Added: August 28, 2023

2023 article

Bayesian matrix completion for hypothesis testing

Jin, B., Dunson, D. B., Rager, J. E., Reif, D. M., Engel, S. M., & Herring, A. H. (2023, March 15). JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES C-APPLIED STATISTICS, Vol. 3.

By: B. Jin*, D. Dunson*, J. Rager*, D. Reif n, S. Engel* & A. Herring*

co-author countries: United States of America 🇺🇸
author keywords: Bayesian hierarchical model; bioactivity profiles; chemical screening; heteroscedasticity; latent factor models; ToxCast; Tox21
Sources: ORCID, Web Of Science
Added: January 4, 2023

2023 article

Deep autoencoder-based behavioral pattern recognition outperforms standard statistical methods in high-dimensional zebrafish studies

Green, A. J., Truong, L., Thunga, P., Leong, C., Hancock, M., Tanguay, R. L., & Reif, D. M. (2023, September 17).

By: A. Green n, L. Truong, P. Thunga n, C. Leong, M. Hancock n, R. Tanguay, D. Reif n

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: September 18, 2023

2023 journal article

Estimation of the Half-Lives of Recently Detected Per- and Polyfluorinated Alkyl Ethers in an Exposed Community

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 57(41), 15348–15355.

By: D. Wallis n, N. Kotlarz n, D. Knappe n, D. Collier*, C. Lea*, D. Reif n, J. McCord*, M. Strynar*, J. DeWitt*, J. Hoppin n

co-author countries: United States of America 🇺🇸
author keywords: exposure; PFAS; water; humans; environment; toxicokinetic modeling
Sources: Web Of Science, ORCID
Added: October 7, 2023

2023 article

From big data to big insights: statistical and bioinformatic approaches for exploring the lipidome

Chappel, J. R., Kirkwood-Donelson, K. I., Reif, D. M., & Baker, E. S. (2023, October 25). ANALYTICAL AND BIOANALYTICAL CHEMISTRY, Vol. 10.

By: J. Chappel n, K. Kirkwood-Donelson*, D. Reif* & E. Baker*

co-author countries: United States of America 🇺🇸
author keywords: Lipidomics; Univariate; Multivariate; Pathway; Enrichment
Sources: Web Of Science, ORCID
Added: November 20, 2023

2023 journal article

Legacy and emerging per- and polyfluoroalkyl substances suppress the neutrophil respiratory burst

JOURNAL OF IMMUNOTOXICOLOGY, 20(1).

By: D. Phelps*, A. Palekar, H. Conley*, G. Ferrero, J. Driggers*, K. Linder*, S. Kullman n, D. Reif n ...

co-author countries: United States of America 🇺🇸
author keywords: Innate immunity; neutrophils; per- and polyfluoroalkyl substances (PFAS); reactive oxygen species; zebrafish
MeSH headings : Animals; Humans; Zebrafish; Neutrophils; Reactive Oxygen Species; Respiratory Burst; Fluorocarbons / toxicity; Alkanesulfonic Acids / toxicity; Environmental Pollutants
Sources: ORCID, Web Of Science
Added: February 15, 2023

2023 journal article

MKX-AS1 Gene Expression Associated with Variation in Drug Response to Oxaliplatin and Clinical Outcomes in Colorectal Cancer Patients

PHARMACEUTICALS, 16(5).

By: R. Gonzalez*, G. Small*, A. Green n, F. Akhtari*, A. Motsinger-Reif*, J. Quintanilha, T. Havener*, D. Reif*, H. McLeod*, T. Wiltshire*

co-author countries: United States of America 🇺🇸
author keywords: precision medicine; colorectal cancer; pharmacogenomics; oxaliplatin; lncRNA's; antisense
Sources: ORCID, Web Of Science
Added: May 19, 2023

2023 journal article

Pharmacogenomic Analyses Implicate B Cell Developmental Status and MKL1 as Determinants of Sensitivity toward Anti-CD20 Monoclonal Antibody Therapy

CELLS, 12(12).

By: G. Small*, F. Akhtari*, A. Green n, T. Havener*, M. Sikes n, J. Quintanhila, R. Gonzalez*, D. Reif* ...

co-author countries: United States of America 🇺🇸
author keywords: rituximab (Rituxan (R)); ofatumumab (Arzerra (R),& nbsp;Kesimpta (R)); obinutuzumab (Gazyva (R)); CD20 (MS4A1); MKL1 (MRTFA); TGFB1
Sources: ORCID, Web Of Science
Added: June 8, 2023

2023 journal article

RYK Gene Expression Associated with Drug Response Variation of Temozolomide and Clinical Outcomes in Glioma Patients

PHARMACEUTICALS, 16(5).

By: R. Gonzalez*, G. Small*, A. Green n, F. Akhtari*, T. Havener*, J. Quintanilha, A. Cipriani*, D. Reif* ...

co-author countries: United States of America 🇺🇸
author keywords: GWAS; chemotherapy; sensitivity; resistance; glioma; drug response; temozolomide; knockdown; overexpression; pharmacogenomics; gene expression; RYK
Sources: ORCID, Web Of Science
Added: May 12, 2023

2023 journal article

Uncovering the common factors of chemical exposure and behavior: Evaluating behavioral effects across a testing battery using factor analysis

NEUROTOXICOLOGY, 99, 264–273.

By: W. Marinello n, S. Gillera n, L. Huang n, J. Rollman n, D. Reif n & H. Patisaul n

co-author countries: United States of America 🇺🇸
author keywords: EDCs; Endocrine disruptors; Neurodevelopment; Neurotoxicology; Organophosphate; Flame retardants; Vole; Behavior
Sources: Web Of Science, ORCID
Added: December 18, 2023

2023 article

Utilizing Aggregated Molecular Phenotype (AMP) Scores to Visualize Simultaneous Molecular Changes in Mass Spectrometry Imaging Data

Chappel, J. R., King, M. E., Fleming, J., Eberlin, L. S., Reif, D. M., & Baker, E. S. (2023, June 5).

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: June 6, 2023

2022 journal article

Comparison of National Vulnerability Indices Used by the Centers for Disease Control and Prevention for the COVID-19 Response

Public Health Reports, 137(4), 803–812.

co-author countries: United States of America 🇺🇸
author keywords: COVID-19; vulnerability; social vulnerability index; GIS; geographic information systems
MeSH headings : COVID-19 / epidemiology; COVID-19 / prevention & control; Centers for Disease Control and Prevention, U.S.; Humans; Pandemics / prevention & control; Public Health; United States / epidemiology
Sources: ORCID, Web Of Science, Crossref
Added: May 6, 2022

2022 journal article

Demonstrating a systems approach for integrating disparate data streams to inform decisions on children's environmental health

BMC PUBLIC HEALTH, 22(1).

By: E. Hubal*, N. DeLuca*, A. Mullikin*, R. Slover*, J. Little* & D. Reif n

co-author countries: United States of America 🇺🇸
author keywords: Chemical exposure; ANOVA; ToxPi; Children's health; Environmental health; Systems approach; Multivariate analysis; Data-driven
MeSH headings : Child; Child Health; Child, Preschool; Environmental Health; Humans; Lead; Public Health; Systems Analysis
Sources: Web Of Science, ORCID
Added: March 7, 2022

2022 journal article

Systematic developmental toxicity assessment of a structurally diverse library of PFAS in zebrafish

JOURNAL OF HAZARDOUS MATERIALS, 431.

By: L. Truong*, Y. Rericha*, P. Thunga n, S. Marvel n, D. Wallis n, M. Simonich*, J. Field*, D. Cao*, D. Reif n, R. Tanguay n

co-author countries: United States of America 🇺🇸
author keywords: PFAS; Developmental toxicity; Structure-activity relationship; Abnormal behavior; Zebrafish
MeSH headings : Animals; Fluorocarbons / analysis; Larva; Teratogens; Zebrafish
Sources: Web Of Science, ORCID
Added: March 8, 2022

2022 article

TCDD alters essential transcriptional regulators of osteogenic differentiation in multipotent mesenchymal stem cells

Watson, A. L. T. D., Carmona Baez, A., Jima, D., Reif, D., Ding, J., Roberts, R., & Kullman, S. W. (2022, November 12). TOXICOLOGICAL SCIENCES, Vol. 11.

co-author countries: Canada 🇨🇦 United States of America 🇺🇸
author keywords: mesenchymal stem cell; AhR; cell differentiation
MeSH headings : Humans; Osteogenesis / genetics; Polychlorinated Dibenzodioxins / toxicity; Cell Differentiation; Fibroblast Growth Factors / metabolism; Mesenchymal Stem Cells / metabolism; Cells, Cultured; Osteoblasts
Sources: ORCID, Web Of Science
Added: November 12, 2022

2022 article

The Ahr2-Dependent wfikkn1 Gene Influences Zebrafish Transcriptome, Proteome, and Behavior

Shankar, P., Garcia, G. R., LaDu, J. K., Sullivan, C. M., Dunham, C. L., Goodale, B. C., … Tanguay, R. L. (2022, April 4). TOXICOLOGICAL SCIENCES, Vol. 4.

By: P. Shankar*, G. Garcia*, J. LaDu*, C. Sullivan*, C. Dunham*, B. Goodale*, K. Waters*, S. Stanisheuski* ...

co-author countries: United States of America 🇺🇸
author keywords: aryl hydrocarbon receptor (AHR); zebrafish; TCDD; wfikkn1; transcriptomics; behavior
MeSH headings : Animals; Embryo, Nonmammalian; Polychlorinated Dibenzodioxins / toxicity; Polycyclic Aromatic Hydrocarbons / toxicity; Proteome / genetics; Proteome / metabolism; Receptors, Aryl Hydrocarbon / genetics; Receptors, Aryl Hydrocarbon / metabolism; Transcriptome; Zebrafish / genetics; Zebrafish / metabolism; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
Sources: Web Of Science, ORCID
Added: May 2, 2022

2022 article

ToxPi*GIS Toolkit: creating, viewing, and sharing integrative visualizations for geospatial data using ArcGIS

Fleming, J., Marvel, S. W., Supak, S., Motsinger-Reif, A. A., & Reif, D. M. (2022, April 26). JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY, Vol. 4.

By: J. Fleming n, S. Marvel n, S. Supak n, A. Motsinger-Reif* & D. Reif n

co-author countries: United States of America 🇺🇸
author keywords: Visual analytics; Geographic information systems; Data integration
MeSH headings : Humans; Geographic Information Systems; COVID-19
Sources: Web Of Science, ORCID
Added: May 10, 2022

2022 journal article

Utilizing Pine Needles to Temporally and Spatially Profile Per- and Polyfluoroalkyl Substances (PFAS)

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 56(6), 3441–3451.

By: K. Kirkwood n, J. Fleming n, H. Nguyen n, D. Reif n, E. Baker n & S. Belcher n

co-author countries: United States of America 🇺🇸
author keywords: Biomonitoring; contamination; per- and polyfluoroalkyl substances; fluoroethers; ion mobility; mass spectrometry; PFAS
MeSH headings : Alkanesulfonic Acids / analysis; Chromatography, Liquid; Fluorocarbons / analysis; United States; United States Environmental Protection Agency
Sources: Web Of Science, ORCID
Added: February 18, 2022

2022 journal article

Utilizing a Population-Genetic Framework to Test for Gene-Environment Interactions between Zebrafish Behavior and Chemical Exposure

TOXICS, 10(12).

By: P. Thunga n, L. Truong*, Y. Rericha*, J. Du*, M. Morshead*, R. Tanguay*, D. Reif n

co-author countries: United States of America 🇺🇸
author keywords: gene-environment interaction; chemical risk-assessment; zebrafish behavior; toxicity screening
Sources: ORCID, Web Of Science
Added: December 10, 2022

2022 journal article

Wildfires and extracellular vesicles: Exosomal MicroRNAs as mediators of cross-tissue cardiopulmonary responses to biomass smoke

ENVIRONMENT INTERNATIONAL, 167.

By: C. Carberry*, L. Koval*, A. Payton*, H. Hartwell*, Y. Kim, G. Smith*, D. Reif n, I. Jaspers*, M. Gilmour*, J. Rager*

co-author countries: United States of America 🇺🇸
author keywords: Exosomes; Extracellular vesicles; Environmental exposures; Mixtures; Systems biology; Wildfires
MeSH headings : Animals; Biomass; Extracellular Vesicles / metabolism; Female; Hypoxia; Mice; MicroRNAs; Soil; Wildfires
Sources: Web Of Science, ORCID
Added: October 3, 2022

2021 journal article

Concurrent Evaluation of Mortality and Behavioral Responses: A Fast and Efficient Testing Approach for High-Throughput Chemical Hazard Identification

Frontiers in Toxicology, 3.

By: P. Thunga n, L. Truong*, R. Tanguay* & D. Reif n

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: June 22, 2021

2021 journal article

Development of a Pandemic Awareness STEM Outreach Curriculum: Utilizing a Computational Thinking Taxonomy Framework

EDUCATION SCIENCES, 11(3).

By: P. Gilchrist n, A. Alexander n, A. Green n, F. Sanders*, A. Hooker* & D. Reif n

co-author countries: United States of America 🇺🇸
author keywords: science learning; STEM competencies; informal learning; computational thinking; education; curriculum development; data science; teaching; problem solving
Sources: ORCID, Web Of Science
Added: March 9, 2021

2021 article

Extending the lymphoblastoid cell line model for drug combination pharmacogenomics

Green, A. J., Anchang, B., Akhtari, F. S., Reif, D. M., & Motsinger-Reif, A. (2021, May 28). PHARMACOGENOMICS, Vol. 22.

co-author countries: United States of America 🇺🇸
author keywords: combination treatment; drug response; LCLs; omics; synergism
MeSH headings : Antineoplastic Combined Chemotherapy Protocols / administration & dosage; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Cell Line, Tumor / drug effects; Humans; Lymphocytes / drug effects; Pharmacogenomic Testing / methods
Sources: ORCID, Web Of Science
Added: May 29, 2021

2021 journal article

High-throughput screening and genome-wide analyses of 44 anticancer drugs in the 1000 Genomes cell lines reveals an association of the NQO1 gene with the response of multiple anticancer drugs

PLOS GENETICS, 17(8).

By: F. Akhtari n, A. Green n, G. Small*, T. Havener*, J. House*, K. Roell n, D. Reif n, H. McLeod, T. Wiltshire*, A. Motsinger-Reif*

co-author countries: United States of America 🇺🇸

Ed(s): F. Vazquez

MeSH headings : Antineoplastic Agents / pharmacology; Biomarkers, Pharmacological / analysis; Cell Line, Tumor; Genome-Wide Association Study / methods; High-Throughput Screening Assays / methods; Humans; NAD(P)H Dehydrogenase (Quinone) / drug effects; NAD(P)H Dehydrogenase (Quinone) / genetics; NAD(P)H Dehydrogenase (Quinone) / metabolism
Sources: ORCID, Web Of Science
Added: August 27, 2021

2021 journal article

Leveraging high-throughput screening data, deep neural networks, and conditional generative adversarial networks to advance predictive toxicology

PLOS COMPUTATIONAL BIOLOGY, 17(7).

By: A. Green n, M. Mohlenkamp*, J. Das*, M. Chaudhari*, L. Truong*, R. Tanguay*, D. Reif n

co-author countries: United States of America 🇺🇸

Ed(s): V. Hatzimanikatis

MeSH headings : Animals; Computational Biology; Embryo, Nonmammalian / drug effects; High-Throughput Screening Assays; Models, Chemical; Neural Networks, Computer; Toxicity Tests; Toxicology; Zebrafish
Sources: ORCID, Web Of Science
Added: July 5, 2021

2021 journal article

Multiomic Big Data Analysis Challenges: Increasing Confidence in the Interpretation of Artificial Intelligence Assessments

ANALYTICAL CHEMISTRY, 93(22), 7763–7773.

By: M. Odenkirk n, D. Reif n & E. Baker n

co-author countries: United States of America 🇺🇸
MeSH headings : Artificial Intelligence; Big Data; Data Analysis
Sources: Web Of Science, ORCID
Added: July 19, 2021

2021 personal communication

The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard: Monitoring County-Level Vulnerability Using Visualization, Statistical Modeling, and Machine Learning

Marvel, S. W., House, J. S., Wheeler, M., Song, K., Zhou, Y.-H., Wright, F. A., … Reif, D. M. (2021, January).

co-author countries: United States of America 🇺🇸
MeSH headings : COVID-19 / epidemiology; Data Visualization; Health Status Indicators; Humans; Machine Learning; Models, Statistical; Vulnerable Populations
Sources: Web Of Science, ORCID
Added: March 22, 2021

2021 article

ToxPi*GIS Toolkit: Creating, viewing, and sharing integrative visualizations for geospatial data using ArcGIS

Fleming, J., Marvel, S. W., Motsinger-Reif, A. A., & Reif, D. M. (2021, October 11). (Vol. 10). Vol. 10.

By: J. Fleming n, S. Marvel n, A. Motsinger-Reif* & D. Reif n

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: October 13, 2021

2021 review

Uncovering Evidence for Endocrine-Disrupting Chemicals That Elicit Differential Susceptibility through Gene-Environment Interactions

[Review of ]. TOXICS, 9(4).

co-author countries: United States of America 🇺🇸
author keywords: endocrine-disrupting chemical (EDC); gene-environment interaction (GxE); differential susceptibility
Sources: ORCID, Web Of Science
Added: April 7, 2021

2021 article

Utilizing Pine Needles to Temporally and Spatially Profile Per- and Polyfluoroalkyl Substances

Kirkwood, K. I., Fleming, J., Nguyen, H., Reif, D. M., Baker, E. S., & Belcher, S. M. (2021, August 26). (Vol. 8). Vol. 8.

By: K. Kirkwood n, J. Fleming n, H. Nguyen n, D. Reif n, E. Baker n & S. Belcher n

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: August 27, 2021

2020 article

Bayesian Matrix Completion for Hypothesis Testing

(2020, September 17).

David Reif

Source: ORCID
Added: September 24, 2020

2020 journal article

Children’s Environmental Health: A Systems Approach for Anticipating Impacts from Chemicals

International Journal of Environmental Research and Public Health, 17(22), 8337.

By: E. Hubal*, D. Reif n, R. Slover*, A. Mullikin* & J. Little*

co-author countries: United States of America 🇺🇸
author keywords: systems approach; children’ s environmental health
Source: ORCID
Added: November 13, 2020

2020 journal article

Concentration-response evaluation of ToxCast compounds for multivariate activity patterns of neural network function

ARCHIVES OF TOXICOLOGY, 94(2), 469–484.

By: M. Kosnik n, J. Strickland*, S. Marvel n, D. Wallis n, K. Wallace*, A. Richard*, D. Reif n, T. Shafer*

co-author countries: Sweden 🇸🇪 United States of America 🇺🇸
author keywords: Neurotoxicity; Screening; ToxCast
MeSH headings : Animals; Cell Culture Techniques / instrumentation; Cell Culture Techniques / methods; Databases, Chemical; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical / methods; Machine Learning; Microelectrodes; Nerve Net / drug effects; Neural Networks, Computer; Neurons / drug effects; Neurotoxicity Syndromes / pathology; Rats, Long-Evans; Toxicity Tests / methods
Sources: Web Of Science, ORCID
Added: March 30, 2020

2020 journal article

HGBEnviroScreen: Enabling Community Action through Data Integration in the Houston–Galveston–Brazoria Region

International Journal of Environmental Research and Public Health, 17(4), 1130.

By: S. Bhandari*, P. Lewis*, E. Craft*, S. Marvel n, D. Reif n & W. Chiu*

co-author countries: United States of America 🇺🇸
author keywords: environmental justice; geographic information systems; vulnerable populations; community; public health; data; screening; enviroscreen
MeSH headings : Accidents, Occupational; Community Participation; Disasters; Environmental Exposure; Floods; Humans; Public Health; Risk Assessment; Risk Factors; Vulnerable Populations
Source: ORCID
Added: February 15, 2020

2020 journal article

In vivo assessment of respiratory burst inhibition by xenobiotic exposure using larval zebrafish

Journal of Immunotoxicology, 17(1), 94–104.

co-author countries: United States of America 🇺🇸
author keywords: Chemical screen; high throughput; phagocyte; reactive oxygen species (ROS); polycyclic aromatic hydrocarbons (PAH); endocrine disrupting compounds (EDC); lead
MeSH headings : Animals; Animals, Genetically Modified; Benzo(a)pyrene / adverse effects; Blood Cell Count; Cytotoxicity Tests, Immunologic / methods; Embryo, Nonmammalian; Estradiol / adverse effects; Feasibility Studies; High-Throughput Screening Assays / methods; Immunity, Innate / drug effects; Macrophages / drug effects; Macrophages / immunology; Methoxychlor / adverse effects; Neutrophils / drug effects; Neutrophils / immunology; Organometallic Compounds / adverse effects; Phenanthrenes / adverse effects; Reactive Oxygen Species / analysis; Reactive Oxygen Species / metabolism; Respiratory Burst / drug effects; Respiratory Burst / immunology; Zebrafish
Source: ORCID
Added: May 15, 2020

2020 journal article

Inappropriate Citation of Vaccine Article

The Journal of Infectious Diseases, 222(8), 1413–1414.

By: D. Reif n, S. Chanock*, K. Edwards* & J. Crowe*

co-author countries: United States of America 🇺🇸
MeSH headings : Humans; Smallpox; Vaccination; Vaccines / adverse effects
Source: ORCID
Added: June 19, 2019

2020 journal article

Structural-based connectivity and omic phenotype evaluations (SCOPE): a cheminformatics toolbox for investigating lipidomic changes in complex systems

ANALYST, 145(22), 7197–7209.

By: M. Odenkirk n, P. Zin n, J. Ash n, D. Reif n, D. Fourches n & E. Baker n

co-author countries: Japan 🇯🇵 United States of America 🇺🇸
MeSH headings : Cheminformatics; Lipidomics; Lipids; Mass Spectrometry; Phenotype
Sources: Web Of Science, ORCID
Added: November 24, 2020

2020 article

The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard: monitoring county level vulnerability

Marvel, S. W., House, J. S., Wheeler, M., Song, K., Zhou, Y., Wright, F. A., … Reif, D. M. (2020, August 13). MedRxiv, Vol. 8.

By: S. Marvel n, J. House*, M. Wheeler*, K. Song n, Y. Zhou n, F. Wright n, W. Chiu*, I. Rusyn*, A. Motsinger-Reif*, D. Reif n

co-author countries: United States of America 🇺🇸

Contributors: S. Marvel n, J. House*, M. Wheeler*, K. Song n, Y. Zhou n, F. Wright n, W. Chiu*, I. Rusyn*, A. Motsinger-Reif*, D. Reif n

Source: ORCID
Added: August 21, 2020

2020 journal article

The multi-dimensional embryonic zebrafish platform predicts flame retardant bioactivity

REPRODUCTIVE TOXICOLOGY, 96, 359–369.

By: L. Truong*, S. Marvel n, D. Reif n, D. Thomas*, P. Pande*, S. Dasgupta*, M. Simonich*, K. Waters*, R. Tanguay*

co-author countries: United States of America 🇺🇸
author keywords: Developmental toxicity; Flame retardants; Benchmark dose; Lowest effect concentration; Neurotoxicity; Classification model
MeSH headings : Animals; Embryo, Nonmammalian; Embryonic Development / drug effects; Flame Retardants / toxicity; Models, Animal; Neurotoxicity Syndromes; Risk Assessment; Structure-Activity Relationship; Teratogens / chemistry; Teratogens / toxicity; Zebrafish
Sources: Web Of Science, ORCID
Added: November 30, 2020

2019 journal article

Associations between access to healthcare, environmental quality, and end-stage renal disease survival time: Proportional-hazards models of over 1,000,000 people over 14 years

PLOS ONE, 14(3).

By: M. Kosnik n, D. Reif n, D. Lobdell*, T. Astell-Burt*, X. Feng*, J. Hader*, J. Hoppin n

co-author countries: Australia 🇦🇺 China 🇨🇳 United States of America 🇺🇸

Contributors: M. Kosnik n, D. Reif n, D. Lobdell*, T. Astell-Burt*, X. Feng*, J. Hader*, J. Hoppin n

Ed(s): W. Cheungpasitporn

MeSH headings : Adolescent; Adult; Aged; Air Pollution / adverse effects; Female; Health Services Accessibility; Humans; Kidney Failure, Chronic / epidemiology; Male; Middle Aged; Prevalence; Proportional Hazards Models; Risk Factors; Socioeconomic Factors; United States / epidemiology; Water Quality; Young Adult
Sources: Web Of Science, ORCID
Added: April 9, 2019

2019 journal article

Determination of chemical-disease risk values to prioritize connections between environmental factors, genetic variants, and human diseases

Toxicology and Applied Pharmacology, 379, 114674.

By: M. Kosnik n & D. Reif n

co-author countries: United States of America 🇺🇸

Contributors: M. Kosnik n & D. Reif n

author keywords: Data integration; Risk assessment; New approach methodologies; Gene-environment interactions
MeSH headings : Animals; Databases, Factual; Datasets as Topic; Environmental Exposure / adverse effects; Environmental Exposure / statistics & numerical data; Gene-Environment Interaction; Genetic Predisposition to Disease / etiology; Genetic Predisposition to Disease / genetics; Genetic Variation; High-Throughput Screening Assays; Humans; Information Storage and Retrieval; Risk Assessment / methods; Toxicology / methods
Source: ORCID
Added: July 17, 2019

2019 journal article

Integration of curated and high-throughput screening data to elucidate environmental influences on disease pathways

Computational Toxicology, 12, 100094.

By: M. Kosnik n, A. Planchart n, S. Marvel n, D. Reif n & C. Mattingly n

co-author countries: United States of America 🇺🇸

Contributors: M. Kosnik n, A. Planchart n, S. Marvel n, D. Reif n & C. Mattingly n

Sources: ORCID, Crossref
Added: August 30, 2019

2019 journal article

Multivariate modeling of engineered nanomaterial features associated with developmental toxicity

NanoImpact, 16.

co-author countries: United States of America 🇺🇸

Contributors: K. To n, L. Truong*, S. Edwards*, R. Tanguay* & D. Reif n

author keywords: Engineered nanomaterials; Predictive modeling; Feature analysis; Developmental toxicity; Zebrafish
Source: ORCID
Added: December 4, 2019

2019 journal article

Population-based toxicity screening in human induced pluripotent stem cell-derived cardiomyocytes

Toxicology and Applied Pharmacology, 381.

By: S. Burnett*, A. Blanchette*, F. Grimm*, J. House n, D. Reif n, F. Wright n, W. Chiu*, I. Rusyn*

co-author countries: United States of America 🇺🇸

Contributors: S. Burnett*, A. Blanchette*, F. Grimm*, J. House n, D. Reif n, F. Wright n, W. Chiu*, I. Rusyn*

author keywords: iPSC; In vitro; Alternative methods; Cardiotoxicity; High-content screening; Environmental chemicals
MeSH headings : Calcium / metabolism; Cardiotoxicity; Cells, Cultured; Drug Evaluation, Preclinical / methods; Female; Genotype; Humans; Induced Pluripotent Stem Cells / cytology; Male; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / metabolism; Phenotype; Racial Groups; Toxicity Tests / methods
Source: ORCID
Added: August 30, 2019

2019 journal article

Sex-specific effects of perinatal FireMaster® 550 (FM 550) exposure on socioemotional behavior in prairie voles

Neurotoxicology and Teratology, 79, 106840.

By: S. Gillera n, W. Marinello n, B. Horman n, A. Phillips*, M. Ruis*, H. Stapleton*, D. Reif n, H. Patisaul n

co-author countries: United States of America 🇺🇸

Contributors: S. Gillera n, W. Marinello n, B. Horman n, A. Phillips*, M. Ruis*, H. Stapleton*, D. Reif n, H. Patisaul n

author keywords: Social; Anxiety; Brain; Neurodevelopment; Neural; Endocrine disruptors; Endocrine disrupting chemicals; Flame retardants
MeSH headings : Animals; Anxiety / chemically induced; Arvicolinae; Behavior, Animal / drug effects; Exploratory Behavior / drug effects; Female; Flame Retardants / toxicity; Male; Organophosphates / toxicity; Polybrominated Biphenyls / toxicity; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / psychology; Sex Characteristics; Social Behavior
Source: ORCID
Added: December 4, 2019

2019 journal article

Synergistic Chemotherapy Drug Response Is a Genetic Trait in Lymphoblastoid Cell Lines

FRONTIERS IN GENETICS, 10.

By: K. Roell n, T. Havener*, D. Reif n, J. Jack n, H. McLeod*, T. Wiltshire*, A. Motsinger-Reif*

co-author countries: United States of America 🇺🇸

Contributors: K. Roell n, T. Havener*, D. Reif n, J. Jack n, H. McLeod*, T. Wiltshire*, A. Motsinger-Reif*

author keywords: synergy; heritability; chemotherapy; lymphoblastoid cell lines; linkage mapping
Sources: Web Of Science, ORCID
Added: December 2, 2019

2019 journal article

Systematic determination of the relationship between nanoparticle core diameter and toxicity for a series of structurally analogous gold nanoparticles in zebrafish

Nanotoxicology, 4, 1—15.

co-author countries: United States of America 🇺🇸

Contributors: L. Truong*, T. Zaikova*, B. Baldock*, M. Balik-Meisner n, K. To n, D. Reif n, Z. Kennedy*, J. Hutchison*, R. Tanguay*

author keywords: Size-dependency; gold nanoparticles; zebrafish; uptake; ligands
MeSH headings : Animals; Gold / toxicity; Metal Nanoparticles / toxicity; Particle Size; Zebrafish
Source: ORCID
Added: May 14, 2019

2018 journal article

Characterizing the effects of missing data and evaluating imputation methods for chemical prioritization applications using ToxPi

BIODATA MINING, 11(1).

By: K. To n, R. Fry* & D. Reif n

co-author countries: United States of America 🇺🇸

Contributors: K. To n, R. Fry* & D. Reif n

author keywords: Chemical prioritization; ToxPi; ToxCast; Missing data; Imputation; Multiple imputation; Simulation
Sources: Web Of Science, ORCID
Added: August 6, 2018

2018 journal article

Confirmation of high-throughput screening data and novel mechanistic insights into VDR-xenobiotic interactions by orthogonal assays

Scientific Reports, 8(1).

By: D. Mahapatra n, J. Franzosa*, K. Roell n, M. Kuenemann n, K. Houck*, D. Reif n, D. Fourches n, S. Kullman n

co-author countries: United States of America 🇺🇸

Contributors: D. Mahapatra n, J. Franzosa*, K. Roell n, M. Kuenemann n, K. Houck*, D. Reif n, D. Fourches n, S. Kullman n

MeSH headings : Drug Evaluation, Preclinical; Genes, Reporter; High-Throughput Screening Assays; Humans; Luciferases / analysis; Luciferases / genetics; Protein Binding; Receptors, Calcitriol / agonists; Receptors, Calcitriol / antagonists & inhibitors; Two-Hybrid System Techniques; Xenobiotics / metabolism
Sources: ORCID, Crossref, NC State University Libraries
Added: August 6, 2018

2018 journal article

Elucidating Gene-by-Environment Interactions Associated with Differential Susceptibility to Chemical Exposure.

Environmental Health Perspectives, 6(6).

By: M. Balik-Meisner n, L. Truong*, E. Scholl n, D. La*, R. Tanguay* & D. Reif n

co-author countries: United States of America 🇺🇸

Contributors: M. Balik-Meisner n, L. Truong*, E. Scholl n, J. La Du*, R. Tanguay* & D. Reif n

MeSH headings : Animals; Embryo, Nonmammalian / drug effects; Embryonic Development / drug effects; Female; Gene-Environment Interaction; Genetic Variation; Genome-Wide Association Study; High-Throughput Screening Assays / methods; Ivermectin / analogs & derivatives; Ivermectin / toxicity; Male; Phenotype; Zebrafish / embryology; Zebrafish / genetics
Source: ORCID
Added: May 14, 2019

2018 journal article

Neonatal mice exposed to a high-fat diet in utero influence the behaviour of their nursing dam

Proceedings of the Royal Society B: Biological Sciences, 285(1891), 20181237.

By: M. Baptissart n, H. Lamb n, K. To n, C. Bradish n, J. Tehrani n, D. Reif n, M. Cowley n

co-author countries: United States of America 🇺🇸

Contributors: M. Baptissart n, H. Lamb n, K. To n, C. Bradish n, J. Tehrani n, D. Reif n, M. Cowley n

MeSH headings : Animals; Animals, Newborn / physiology; Diet, High-Fat; Female; Maternal Behavior / physiology; Maternal Exposure; Mice / physiology; Mice, Inbred C57BL; Pregnancy
Sources: NC State University Libraries, ORCID
Added: December 10, 2018

2018 journal article

Population genetic diversity in zebrafish lines

MAMMALIAN GENOME, 29(1-2), 90–100.

co-author countries: United States of America 🇺🇸

Contributors: M. Balik-Meisner n, L. Truong*, E. Scholl n, R. Tanguay* & D. Reif n

MeSH headings : Animals; Gene Frequency; Genetic Variation; Genetics, Population; Genome / genetics; Polymorphism, Single Nucleotide / genetics; Zebrafish / genetics
Sources: Web Of Science, ORCID
Added: August 6, 2018

2018 journal article

ToxPi Graphical User Interface 2.0: Dynamic exploration, visualization, and sharing of integrated data models.

BMC Bioinformatics, 3(1).

By: S. Marvel n, K. To n, F. Grimm*, F. Wright n, I. Rusyn* & D. Reif n

co-author countries: United States of America 🇺🇸

Contributors: S. Marvel n, K. To n, F. Grimm*, F. Wright n, I. Rusyn* & D. Reif n

author keywords: Visual analytics; Software; systems biology; Risk assessment; Data integration; Graphical user interface
MeSH headings : Cluster Analysis; Information Dissemination; Information Storage and Retrieval; Models, Theoretical; Software; User-Computer Interface
Sources: ORCID, NC State University Libraries
Added: August 6, 2018

2018 journal article

Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups.

ALTEX, 35(1), 51–64.

By: W. Chiu*, K. Guyton*, M. Martin*, D. Reif n & I. Rusyn*

co-author countries: France 🇫🇷 United States of America 🇺🇸

Contributors: W. Chiu*, K. Guyton*, M. Martin*, D. Reif n & I. Rusyn*

author keywords: carcinogenicity; high throughput screening; in vitro; mechanisms
MeSH headings : Animals; Biological Assay; Carcinogenicity Tests; Carcinogens / toxicity; High-Throughput Screening Assays / methods; Humans; International Agencies; Publications; United States; United States Environmental Protection Agency
Sources: ORCID, NC State University Libraries
Added: August 6, 2018

2017 journal article

A New Statistical Approach to Characterize Chemical-Elicited Behavioral Effects in High-Throughput Studies Using Zebrafish

PLOS ONE, 12(1).

co-author countries: United States of America 🇺🇸

Contributors: G. Zhang n, L. Truong*, R. Tanguay* & D. Reif n

Ed(s): S. Neuhauss

MeSH headings : Animals; Biometry / methods; High-Throughput Screening Assays / methods; Models, Statistical; Zebrafish
Sources: ORCID, Web Of Science
Added: August 6, 2018

2017 journal article

A data-driven weighting scheme for multivariate phenotypic endpoints recapitulates zebrafish developmental cascades

TOXICOLOGY AND APPLIED PHARMACOLOGY, 314, 109–117.

co-author countries: United States of America 🇺🇸

Contributors: G. Zhang n, K. Roell n, L. Truong*, R. Tanguay* & D. Reif n

author keywords: Zebrafish; High-dimensional; Bayesian; Developmental cascade; ToxRefDB; Risk assessment; Multiple endpoints; Multivariate; Scoring
MeSH headings : Animals; Models, Theoretical; Multivariate Analysis; Phenotype; Zebrafish / embryology
Sources: ORCID, Web Of Science
Added: August 6, 2018

2017 journal article

An introduction to terminology and methodology of chemical synergy-perspectives from across disciplines

Frontiers in Pharmacology, 8(APR).

co-author countries: United States of America 🇺🇸

Contributors: K. Roell n, D. Reif n & A. Motsinger-Reif n

author keywords: synergy; mixtures; non-additive; interactions; drug combinations
Source: ORCID
Added: May 14, 2019

2017 review

An introduction to terminology and methodology of chemical synergy-perspectives from across disciplines

[Review of ]. Frontiers in Pharmacology, 8.

By: K. Roell, D. Reif & A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Incorporating ToxCast and Tox21 datasets to rank biological activity of chemicals at Superfund sites in North Carolina

ENVIRONMENT INTERNATIONAL, 101, 19–26.

By: S. Tilley*, D. Reif n & R. Fry*

co-author countries: United States of America 🇺🇸

Contributors: S. Tilley*, D. Reif n & R. Fry*

author keywords: North Carolina; Risk assessment; Superfund; Tox21; ToxCast; ToxPi
MeSH headings : Databases, Factual; Environmental Pollutants / toxicity; Hazardous Waste / economics; Hazardous Waste / legislation & jurisprudence; Humans; North Carolina; Public Health; Risk Assessment; United States; United States Environmental Protection Agency; Waste Management / standards
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 article

Integrating Morphological and Behavioral Phenotypes in Developing Zebrafish

The Rights and Wrongs of Zebrafish: Behavioral Phenotyping of Zebrafish, pp. 259–272.

co-author countries: United States of America 🇺🇸

Contributors: G. Zhang n, L. Truong*, R. Tanguay* & D. Reif n

Source: ORCID
Added: May 14, 2019

2017 journal article

Transgenerational inheritance of neurobehavioral and physiological deficits from developmental exposure to benzo[a]pyrene in zebrafish

TOXICOLOGY AND APPLIED PHARMACOLOGY, 329, 148–157.

By: A. Knecht*, L. Truong*, S. Marvel n, D. Reif n, A. Garcia*, C. Lu*, M. Simbnich, J. Teeguarden*, R. Tanguay*

co-author countries: United States of America 🇺🇸

Contributors: A. Knecht*, L. Truong*, S. Marvel n, D. Reif n, A. Garcia*, C. Lu*, M. Simonich*, J. Teeguarden*, R. Tanguay*

author keywords: Zebrafish Benzo[a]pyrene; Transgenerational; Neurobehavioral; Developmental toxicity; Physiological deficits; Aryl hydrocarbon receptor
MeSH headings : Animals; Animals, Genetically Modified; Behavior, Animal / drug effects; Benzo(a)pyrene / toxicity; DNA Methylation / drug effects; DNA Modification Methylases / metabolism; Dose-Response Relationship, Drug; Epigenesis, Genetic / drug effects; Genotype; Heart Rate / drug effects; Heredity; Inheritance Patterns / drug effects; Learning / drug effects; Mitochondria / drug effects; Mitochondria / metabolism; Motor Activity / drug effects; Neurotoxicity Syndromes / genetics; Neurotoxicity Syndromes / metabolism; Neurotoxicity Syndromes / physiopathology; Phenotype; Repressor Proteins / agonists; Repressor Proteins / deficiency; Repressor Proteins / genetics; Respiration / drug effects; Risk Assessment; Social Behavior; Time Factors; Water Pollutants, Chemical / toxicity; Zebrafish / genetics; Zebrafish / growth & development; Zebrafish / metabolism; Zebrafish Proteins / agonists; Zebrafish Proteins / deficiency; Zebrafish Proteins / genetics
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

A chemical-biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives

GREEN CHEMISTRY, 18(16), 4407–4419.

By: F. Grimm*, Y. Iwata*, O. Sirenko*, G. Chappell*, F. Wright n, D. Reif n, J. Braisted*, D. Gerhold* ...

co-author countries: Belgium 🇧🇪 Germany 🇩🇪 United States of America 🇺🇸

Contributors: F. Grimm*, Y. Iwata*, O. Sirenko*, G. Chappell*, F. Wright n, D. Reif n, J. Braisted*, D. Gerhold* ...

Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

Advancing Exposure Science through Chemical Data Curation and Integration in the Comparative Toxicogenomics Database

Environmental Health Perspectives, 124(10), 1592–1599.

By: C. Grondin n, A. Davis n, T. Wiegers n, B. King*, J. Wiegers n, D. Reif n, J. Hoppin n, C. Mattingly n

co-author countries: United States of America 🇺🇸

Contributors: C. Grondin n, A. Davis n, T. Wiegers n, B. King*, J. Wiegers n, D. Reif n, J. Hoppin n, C. Mattingly n

Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2016 journal article

Advancing Exposure Science through Chemical Data Curation and Integration in the Comparative Toxicogenomics Database.

Environmental Health Perspectives, 10. http://europepmc.org/abstract/med/27170236

By: C. Grondin, A. Davis, T. Wiegers, B. King, J. Wiegers, D. Reif, J. Hoppin, C. Mattingly

Source: ORCID
Added: May 14, 2019

2016 journal article

Advancing toxicology research using in vivo high throughput toxicology with small fish models

ALTEX, 33(4), 435–452.

By: A. Planchart n, C. Mattingly n, D. Allen*, P. Ceger*, W. Casey*, D. Hinton*, J. Kanungo*, S. Kullman n ...

co-author countries: United States of America 🇺🇸

Contributors: A. Planchart n, C. Mattingly n, D. Allen*, P. Ceger*, W. Casey*, D. Hinton*, J. Kanungo*, S. Kullman n ...

author keywords: aquatic models; 21st century toxicology; alternatives
Sources: ORCID, Crossref, NC State University Libraries
Added: August 6, 2018

2016 journal article

Aggregate entropy scoring for quantifying activity across endpoints with irregular correlation structure

REPRODUCTIVE TOXICOLOGY, 62, 92–99.

co-author countries: United States of America 🇺🇸

Contributors: G. Zhang n, S. Marvel n, L. Truong*, R. Tanguay* & D. Reif n

author keywords: Developmental neurotoxicology; Chemical biology; Morphology; Zebrafish; High throughput screening; ToxCast; Multiplexed assays
MeSH headings : Animals; Embryo, Nonmammalian; Entropy; Flame Retardants / toxicity; High-Throughput Screening Assays; Models, Theoretical; Phenotype; Teratogens / toxicity; Zebrafish / embryology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space.

Toxicological Sciences : an Official Journal of the Society of Toxicology, 10(2), 409–409.

By: R. Judson*, K. Houck*, M. Martin*, A. Richard*, T. Knudsen*, I. Shah*, S. Little*, J. Wambaugh* ...

co-author countries: United States of America 🇺🇸

Contributors: R. Judson*, K. Houck*, M. Martin*, A. Richard*, T. Knudsen*, I. Shah*, S. Little*, J. Wambaugh* ...

Source: ORCID
Added: May 14, 2019

2016 journal article

Decoupling of a neutron interferometer from temperature gradients

Review of Scientific Instruments, 87(12), 123507.

By: P. Saggu*, T. Mineeva*, M. Arif*, D. Cory*, R. Haun*, B. Heacock n, M. Huber*, K. Li* ...

co-author countries: Canada 🇨🇦 United States of America 🇺🇸
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2016 journal article

Editor's Highlight: Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space.

Toxicological Sciences : an Official Journal of the Society of Toxicology, 8(2), 323–339.

By: R. Judson*, K. Houck*, M. Martin*, A. Richard*, T. Knudsen*, I. Shah*, S. Little*, J. Wambaugh* ...

co-author countries: United States of America 🇺🇸

Contributors: R. Judson*, K. Houck*, M. Martin*, A. Richard*, T. Knudsen*, I. Shah*, S. Little*, J. Wambaugh* ...

author keywords: In vitro; high-throughput screening; oxidative stress; cytotoxicity; cell stress
MeSH headings : Biological Assay / methods; Humans; In Vitro Techniques; Stress, Physiological; Toxicity Tests / methods
Source: ORCID
Added: May 14, 2019

2016 journal article

Eigenvector metabolite analysis reveals dietary effects on the association among metabolite correlation patterns, gene expression, and phenotypes

METABOLOMICS, 12(11).

co-author countries: United States of America 🇺🇸

Contributors: C. Scott Chialvo*, R. Che n, D. Reif n, A. Motsinger-Reif n & L. Reed*

author keywords: Eigenvector metabolite analysis; Linkage analyses; Environment; Enrichment analyses
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

Evolutionary and Functional Diversification of the Vitamin D Receptor-Lithocholic Acid Partnership

PLOS ONE, 11(12).

By: E. Kollitz n, G. Zhang n, M. Hawkins n, G. Whitfield*, D. Reif n & S. Kullman n

co-author countries: United States of America 🇺🇸

Contributors: E. Kollitz n, G. Zhang n, M. Hawkins n, G. Whitfield*, D. Reif n & S. Kullman n

Ed(s): C. Zhang n

MeSH headings : Animals; Biological Evolution; Hep G2 Cells; Humans; Lithocholic Acid / metabolism; Receptors, Calcitriol / metabolism; Vertebrates
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

From the Cover: Embryonic Exposure to TCDD Impacts Osteogenesis of the Axial Skeleton in Japanese medaka,Oryzias latipes

Toxicological Sciences, 155(2), 485–496.

co-author countries: Singapore 🇸🇬 United States of America 🇺🇸

Contributors: A. Watson, A. Planchart n, C. Mattingly n, C. Winkler*, D. Reif n & S. Kullman n

author keywords: receptor, aryl hydrocarbon; gene expression/regulation, bone; transgenic models; methods, developmental/teratology; reproductive and developmental toxicology
MeSH headings : Animals; Calcification, Physiologic / drug effects; Down-Regulation / drug effects; Microscopy, Confocal; Musculoskeletal Diseases / metabolism; Oryzias / embryology; Osteogenesis / drug effects; Polychlorinated Dibenzodioxins / toxicity; Real-Time Polymerase Chain Reaction; Skeleton / drug effects; Skeleton / metabolism; Trans-Activators / drug effects
Sources: ORCID, Web Of Science, Crossref
Added: August 6, 2018

2016 journal article

High-throughput characterization of chemical-associated embryonic behavioral changes predicts teratogenic outcomes

ARCHIVES OF TOXICOLOGY, 90(6), 1459–1470.

By: D. Reif n, L. Truong*, D. Mandrell*, S. Marvel n, G. Zhang n & R. Tanguay*

co-author countries: United States of America 🇺🇸

Contributors: D. Reif n, L. Truong*, D. Mandrell*, S. Marvel n, G. Zhang n & R. Tanguay*

author keywords: Developmental neurotoxicology; Alternative testing; Chemical biology; Behavior; Zebrafish; High-throughput screening; Bioinformatics; Data integration; ToxCast; Bioactivity
MeSH headings : Animals; Behavior, Animal / drug effects; Dose-Response Relationship, Drug; Embryo, Nonmammalian / abnormalities; Embryo, Nonmammalian / drug effects; Embryo, Nonmammalian / physiopathology; Hazardous Substances / toxicity; High-Throughput Screening Assays; Predictive Value of Tests; Teratogens / toxicity; Zebrafish / abnormalities; Zebrafish / embryology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

Lifetime substance use as a predictor of postpartum mental health

Archives of Women's Mental Health, 20(1), 189–199.

By: B. Prevatt n, S. Desmarais n & P. Janssen*

co-author countries: Canada 🇨🇦 United States of America 🇺🇸
author keywords: Postpartum mental health; Alcohol use; Drug use; Screening
MeSH headings : Adult; Alcohol Drinking / epidemiology; Alcohol Drinking / psychology; Anxiety / epidemiology; Anxiety / psychology; Canada / epidemiology; Depression, Postpartum / diagnosis; Depression, Postpartum / epidemiology; Depression, Postpartum / psychology; Female; Humans; Interviews as Topic; Mood Disorders / epidemiology; Mood Disorders / psychology; Pregnancy; Risk Factors; Stress Disorders, Post-Traumatic / epidemiology; Stress Disorders, Post-Traumatic / psychology; Substance-Related Disorders / epidemiology; Substance-Related Disorders / psychology; Surveys and Questionnaires; Urban Population; Women's Health; Young Adult
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2016 review

Prioritizing Environmental Chemicals for Obesity and Diabetes Outcomes Research: A Screening Approach Using ToxCast (TM) High-Throughput Data

[Review of ]. ENVIRONMENTAL HEALTH PERSPECTIVES, 124(8), 1141–1154.

By: S. Auerbach*, D. Filer*, D. Reif n, V. Walker*, A. Holloway*, J. Schlezinger*, S. Srinivasan*, D. Svoboda* ...

co-author countries: Canada 🇨🇦 United States of America 🇺🇸

Contributors: S. Auerbach*, D. Filer*, D. Reif n, V. Walker*, A. Holloway*, J. Schlezinger*, S. Srinivasan*, D. Svoboda* ...

MeSH headings : Databases, Factual; Diabetes Mellitus / chemically induced; Diabetes Mellitus / epidemiology; Environment; Environmental Exposure / statistics & numerical data; Environmental Pollutants / standards; Environmental Pollutants / toxicity; High-Throughput Screening Assays; Humans; Obesity / chemically induced; Obesity / epidemiology; Outcome Assessment, Health Care; Risk Assessment; United States; United States Environmental Protection Agency
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

Using toxcast™ data to reconstruct dynamic cell state trajectories and estimate toxicological points of departure

Environmental Health Perspectives, 124(7), 910–919.

By: I. Shah*, R. Setzer*, J. Jack n, K. Houck*, R. Judson*, T. Knudsen*, J. Liu*, M. Martin* ...

co-author countries: United States of America 🇺🇸

Contributors: I. Shah*, R. Woodrow Setzer*, J. Jack n, K. Houck*, R. Judson*, T. Knudsen*, J. Liu*, M. Martin* ...

MeSH headings : Environmental Pollutants / toxicity; High-Throughput Screening Assays; Membrane Potential, Mitochondrial; Risk Assessment; Toxicity Tests / methods
Sources: ORCID, NC State University Libraries
Added: August 6, 2018

2015 journal article

Carcinogenicity of lindane, DDT, and 2,4-dichlorophenoxyacetic acid.

The Lancet. Oncology, 8.

By: D. Loomis*, K. Guyton*, Y. Grosse*, G. El*, V. Bouvard*, L. Benbrahim-Tallaa*, N. Guha*, H. Mattock*, K. Straif*, France

co-author countries: France 🇫🇷
Source: ORCID
Added: May 14, 2019

2015 journal article

Comparison of toxicity values across zebrafish early life stages and mammalian studies: Implications for chemical testing

Reproductive Toxicology, 55, 3–10.

By: N. Ducharme*, D. Reif n, J. Gustafsson* & M. Bondesson*

co-author countries: Sweden 🇸🇪 United States of America 🇺🇸

Contributors: N. Ducharme*, D. Reif n, J. Gustafsson* & M. Bondesson*

author keywords: Meta-analysis; Toxicity; Teratogen; Zebrafish; Human exposure
MeSH headings : Animal Testing Alternatives; Animals; Embryo, Nonmammalian / drug effects; Larva / drug effects; Lethal Dose 50; Mice; Rabbits; Rats; Toxicity Tests / methods; Zebrafish / embryology
Source: ORCID
Added: May 14, 2019

2015 book

Computational Methods Used in Systems Biology

In Systems Biology in Toxicology and Environmental Health (pp. 85–115).

By: M. Meisner & D. Reif*

Contributors: M. Meisner & D. Reif*

Source: ORCID
Added: May 14, 2019

2015 journal article

Data-driven asthma endotypes defined from blood biomarker and gene expression data

PLoS ONE, 10(2).

By: B. George*, D. Reif*, J. Gallagher*, C. Williams-DeVane*, B. Heidenfelder*, E. Hudgens*, W. Jones*, L. Neas*, E. Cohen Hubal*, S. Edwards*

co-author countries: United States of America 🇺🇸

Contributors: B. George*, D. Reif*, J. Gallagher*, C. Williams-DeVane*, B. Heidenfelder*, E. Hudgens*, W. Jones*, L. Neas*, E. Cohen Hubal*, S. Edwards*

MeSH headings : Adaptive Immunity; Anti-Asthmatic Agents / therapeutic use; Asthma / blood; Asthma / classification; Asthma / genetics; Asthma / immunology; Biomarkers / blood; Decision Trees; Eosinophilia / complications; Humans; Immunity, Innate; Medical Informatics / methods; Metabolic Syndrome / complications; Transcriptome
Source: ORCID
Added: May 14, 2019

2015 book

Embracing complexity: Searching for gene-gene and gene environment interactions in genetic epidemiology

In Genomics and Proteomics: Principles, Technologies, and Applications (pp. 19–58).

By: A. Motsinger & D. Reif

Contributors: A. Motsinger & D. Reif

Source: ORCID
Added: May 14, 2019

2015 journal article

Food for Thought...: Toxicity testing in the 21st century beyond environmental chemicals

Altex, 32(3), 171–181.

By: C. Rovida*, S. Asakura*, M. Daneshian*, H. Hofman-Huether*, M. Leist*, L. Meunier*, D. Reif n, A. Rossi* ...

co-author countries: Belgium 🇧🇪 Germany 🇩🇪 Italy 🇮🇹 Japan 🇯🇵 Netherlands 🇳🇱 United States of America 🇺🇸

Contributors: C. Rovida*, S. Asakura*, M. Daneshian*, H. Hofman-Huether*, M. Leist*, L. Meunier*, D. Reif n, A. Rossi* ...

author keywords: food ingredients; drugs; Tox21c; safety assessment
MeSH headings : Animal Testing Alternatives / methods; Animals; Drug Approval; Drug Evaluation / methods; Drug Industry; Humans; In Vitro Techniques; Risk Assessment; Safety / standards; Toxicity Tests / methods; United States; United States Environmental Protection Agency
Source: ORCID
Added: May 14, 2019

2015 journal article

Impact of Low-Dose Oral Exposure to Bisphenol A (BPA) on Juvenile and Adult Rat Exploratory and Anxiety Behavior: A CLARITY-BPA Consortium Study

TOXICOLOGICAL SCIENCES, 148(2), 341–354.

By: M. Rebuli n, L. Camacho*, M. Adonay n, D. Reif n, D. Aylor n & H. Patisaul n

co-author countries: United States of America 🇺🇸

Contributors: M. Rebuli n, L. Camacho*, M. Adonay n, D. Reif n, D. Aylor n & H. Patisaul n

author keywords: bisphenol A; CLARITY; behavior; anxiety; exploratory activity; endocrine disruption; EDC; sexually dimorphic; brain; BPA; plastic
MeSH headings : Age Factors; Animals; Anxiety / chemically induced; Anxiety / psychology; Behavior, Animal / drug effects; Benzhydryl Compounds / toxicity; Dose-Response Relationship, Drug; Endocrine Disruptors / toxicity; Exploratory Behavior / drug effects; Female; Gestational Age; Lactation; Male; Maternal Exposure / adverse effects; Motor Activity / drug effects; Neurotoxicity Syndromes / etiology; Neurotoxicity Syndromes / psychology; Phenols / toxicity; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Sprague-Dawley; Risk Assessment; Sex Factors
Sources: ORCID, Web Of Science
Added: August 6, 2018

2015 journal article

Molecular Cloning, Functional Characterization, and Evolutionary Analysis of Vitamin D Receptors Isolated from Basal Vertebrates

PLOS ONE, 10(4).

By: E. Kollitz n, G. Zhang n, M. Hawkins n, G. Whitfield*, D. Reif n & S. Kullman n

co-author countries: United States of America 🇺🇸

Contributors: E. Kollitz n, G. Zhang n, M. Hawkins n, G. Whitfield*, D. Reif n & S. Kullman n

MeSH headings : Animals; Base Sequence; Cloning, Molecular; Computational Biology; Electrophoretic Mobility Shift Assay; Evolution, Molecular; Fishes / genetics; Likelihood Functions; Models, Genetic; Molecular Sequence Data; Petromyzon / genetics; Phylogeny; Protein Binding; Protein Interaction Mapping; Receptors, Calcitriol / genetics; Sequence Analysis, DNA; Skates, Fish / genetics; Species Specificity; Two-Hybrid System Techniques
Sources: ORCID, Web Of Science
Added: August 6, 2018

2014 journal article

Comparing metabolomic and pathologic biomarkers alone and in combination for discriminating Alzheimer's disease from normal cognitive aging

Acta Neuropathologica Communications, 2(1), 28.

By: A. Motsinger-Reif n, H. Zhu*, M. Kling*, W. Matson*, S. Sharma*, O. Fiehn*, D. Reif n, D. Appleby* ...

co-author countries: United States of America 🇺🇸

Contributors: A. Motsinger-Reif n, H. Zhu*, M. Kling*, W. Matson*, S. Sharma*, O. Fiehn*, D. Reif n, D. Appleby* ...

author keywords: Alzheimer's disease; Dementias; Metabolomics; Cerebrospinal fluid biomarkers; Stepwise logistic regression
MeSH headings : Aged; Aging / cerebrospinal fluid; Aging / drug effects; Aging / pathology; Alzheimer Disease / cerebrospinal fluid; Alzheimer Disease / diagnosis; Alzheimer Disease / drug therapy; Alzheimer Disease / pathology; Amyloid beta-Peptides / cerebrospinal fluid; Area Under Curve; Biomarkers / cerebrospinal fluid; Chromatography, Liquid; Cognition; Diagnosis, Differential; Female; Gas Chromatography-Mass Spectrometry; Humans; Logistic Models; Male; Metabolomics / methods; Neuropsychological Tests; tau Proteins / cerebrospinal fluid
Source: ORCID
Added: May 14, 2019

2014 journal article

Erratum to Incorporating human dosimetry and exposure into High-throughput in Vitro Toxicity Screening [Toxicological sciences 137, 2, (2014), 499]

Toxicological Sciences, 137(2).

By: D. Rotroff, B. Wetmore, D. Dix, S. Ferguson, H. Clewell, K. Houck, E. LeCluyse, M. Andersen ...

Contributors: D. Rotroff, B. Wetmore, D. Dix, S. Ferguson, H. Clewell, K. Houck, E. LeCluyse, M. Andersen ...

Source: ORCID
Added: May 14, 2019

2014 journal article

Hierarchical Dose-Response Modeling for High-Throughput Toxicity Screening of Environmental Chemicals

BIOMETRICS, 70(1), 237–246.

co-author countries: United States of America 🇺🇸

Contributors: A. Wilson n, D. Reif n & B. Reich n

author keywords: Bayesian; Computational toxicology; Dose-response; MCMC; Monotonicity; Semiparametric; ToxCast
MeSH headings : Algorithms; Bayes Theorem; Computer Simulation; Dose-Response Relationship, Drug; Environmental Pollutants / toxicity; Estrogen Receptor alpha / metabolism; Humans; Markov Chains; Models, Statistical; Monte Carlo Method; PPAR gamma / metabolism; Toxicity Tests / methods; United States; United States Environmental Protection Agency
Sources: ORCID, Web Of Science
Added: August 6, 2018

2014 journal article

Multidimensional in vivo hazard assessment using zebrafish.

Toxicological Sciences, 137(1), 212–233.

By: L. Truong*, D. Reif n, M. St*, M. Geier*, H. Truong* & R. Tanguay*

co-author countries: United States of America 🇺🇸

Contributors: L. Truong*, D. Reif n, L. Mary*, M. Geier*, H. Truong* & R. Tanguay*

MeSH headings : Animals; Cluster Analysis; Computational Biology; Dose-Response Relationship, Drug; Embryo, Nonmammalian / drug effects; Embryo, Nonmammalian / metabolism; Embryo, Nonmammalian / pathology; Embryonic Development / drug effects; Environmental Pollutants / toxicity; High-Throughput Screening Assays; Humans; Motor Activity / drug effects; Notochord / drug effects; Notochord / pathology; Reproducibility of Results; Risk Assessment; Toxicity Tests / methods; Zebrafish / embryology
Source: ORCID
Added: May 14, 2019

2014 journal article

Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms

Nature Biotechnology, 32(6), 583–591.

By: N. Kleinstreuer*, J. Yang*, E. Berg*, T. Knudsen*, A. Richard*, M. Martin*, D. Reif*, R. Judson* ...

co-author countries: United States of America 🇺🇸

Contributors: N. Kleinstreuer*, J. Yang*, E. Berg*, T. Knudsen*, A. Richard*, M. Martin*, D. Reif*, R. Judson* ...

MeSH headings : Animal Testing Alternatives / methods; Animals; Computer Simulation; High-Throughput Screening Assays / methods; Humans; Mice; Models, Biological; Phenotype; Rats; Small Molecule Libraries; Toxicity Tests / methods; United States; United States Environmental Protection Agency
Source: ORCID
Added: May 14, 2019

2014 journal article

Predictive endocrine testing in the 21st century using in vitro assays of estrogen receptor signaling responses

Environmental Science and Technology, 48(15), 8706–8716.

By: D. Rotroff*, M. Martin*, D. Dix*, D. Filer*, K. Houck*, T. Knudsen*, N. Sipes*, D. Reif* ...

co-author countries: United States of America 🇺🇸

Contributors: D. Rotroff*, M. Martin*, D. Dix*, D. Filer*, K. Houck*, T. Knudsen*, N. Sipes*, D. Reif* ...

MeSH headings : Algorithms; Animals; Biological Assay; Endocrine Disruptors / analysis; Estrogen Antagonists / analysis; Estrogen Receptor alpha / agonists; Estrogen Receptor alpha / antagonists & inhibitors; Estrogen Receptor beta / agonists; Estrogen Receptor beta / antagonists & inhibitors; Estrogens / analysis; High-Throughput Screening Assays; Humans; MCF-7 Cells; Models, Chemical; Pesticides; Signal Transduction
Source: ORCID
Added: May 14, 2019

2014 journal article

Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway

Scientific Reports, 4.

By: R. Huang*, S. Sakamuru*, M. Martin*, D. Reif*, R. Judson*, K. Houck*, W. Casey*, J. Hsieh* ...

co-author countries: United States of America 🇺🇸

Contributors: R. Huang*, S. Sakamuru*, M. Martin*, D. Reif*, R. Judson*, K. Houck*, W. Casey*, J. Hsieh* ...

MeSH headings : Cell Line; Estrogen Receptor alpha / agonists; Estrogen Receptor alpha / antagonists & inhibitors; Genes, Reporter / drug effects; HEK293 Cells; High-Throughput Screening Assays / methods; Humans; Ligands; Protein Binding / drug effects; Signal Transduction / drug effects; Small Molecule Libraries / pharmacology; Structure-Activity Relationship
Source: ORCID
Added: May 14, 2019

2014 journal article

Test driving ToxCast: endocrine profiling for 1858 chemicals included in phase II

CURRENT OPINION IN PHARMACOLOGY, 19, 145–152.

By: D. Filer*, H. Patisaul n, T. Schug*, D. Reif n & K. Thayer*

co-author countries: United States of America 🇺🇸

Contributors: D. Filer*, H. Patisaul n, T. Schug*, D. Reif n & K. Thayer*

MeSH headings : Animals; Databases, Factual; Endocrine Disruptors / toxicity; High-Throughput Screening Assays; Humans; Models, Theoretical; Risk Assessment; United States; United States Environmental Protection Agency
Sources: ORCID, Web Of Science
Added: August 6, 2018

2014 journal article

ToxiFly: Can fruit flies be used to identify toxicity pathways for airborne chemicals?

Neurotoxicology and Teratology, 43, 89.

By: P. Bushnell*, R. Tatum-Gibbs*, J. McKee*, P. Evansky*, M. Higuchi*, M. MLin*, W. Oshiro*, R. Judson* ...

co-author countries: United States of America 🇺🇸
Sources: Crossref, ORCID
Added: February 21, 2020

2013 journal article

A Computational Model Predicting Disruption of Blood Vessel Development

PLoS Comput Biol, 9(4), e1002996.

By: N. Kleinstreuer*, D. Dix*, M. Rountree*, N. Baker*, N. Sipes*, D. Reif*, R. Spencer*, T. Knudsen*

co-author countries: United States of America 🇺🇸

Contributors: N. Kleinstreuer*, D. Dix*, M. Rountree*, N. Baker*, N. Sipes*, D. Reif*, R. Spencer*, T. Knudsen*

Ed(s): S. Peirce

MeSH headings : Algorithms; Animals; Blood Vessels / embryology; Chemokines / metabolism; Chemotaxis; Computer Simulation; Endothelial Cells / cytology; Endothelium, Vascular / pathology; Humans; Inflammation; Models, Theoretical; Neovascularization, Physiologic; Phenotype; Signal Transduction; Software; Vascular Endothelial Growth Factor A / metabolism
Source: ORCID
Added: May 14, 2019

2013 journal article

Decision tree-based method for integrating gene expression, demographic, and clinical data to determine disease endotypes.

BMC Systems Biology, 7, 119.

By: C. Williams-DeVane*, D. Reif n, E. Cohen Hubal*, P. Bushel*, E. Hudgens*, J. Gallagher*, S. Edwards*

co-author countries: United States of America 🇺🇸

Contributors: C. Williams-DeVane*, D. Reif n, E. Cohen Hubal*, P. Bushel*, E. Hudgens*, J. Gallagher*, S. Edwards*

author keywords: Asthma; Endotypes; Gene Expression; Integrated analysis
MeSH headings : Adolescent; Asthma / blood; Asthma / genetics; Child; Cluster Analysis; Computational Biology / methods; Decision Trees; Demography; Gene Expression Profiling; Genome-Wide Association Study; Humans
Source: ORCID
Added: May 14, 2019

2013 journal article

Dosimetric anchoring of in vivo and in vitro studies for perfluorooctanoate and perfluorooctanesulfonate.

Toxicological Sciences, 136(2), 308–327.

By: J. Wambaugh*, R. Setzer*, A. Pitruzzello*, J. Liu*, D. Reif*, N. Kleinstreuer*, N. Wang*, N. Sipes* ...

co-author countries: United States of America 🇺🇸

Contributors: J. Wambaugh*, R. Setzer*, A. Pitruzzello*, J. Liu*, D. Reif*, N. Kleinstreuer*, N. Wang*, N. Sipes* ...

author keywords: perfluorooctanoate; perfluorooctanoic acid; perfluorooctanesulfonate; perfluorooctanesulfonic acid; compartment model; saturable resorption model; pharmacokinetics; statistical analysis; Bayesian analysis; ToxCast; in vitro-in vivo extrapolation
MeSH headings : Alkanesulfonic Acids / pharmacokinetics; Alkanesulfonic Acids / toxicity; Animals; Caprylates / pharmacokinetics; Caprylates / toxicity; Dose-Response Relationship, Drug; Female; Fluorocarbons / pharmacokinetics; Fluorocarbons / toxicity; In Vitro Techniques; Macaca fascicularis; Male; Mice; Mice, Inbred C57BL; Rats; Rats, Sprague-Dawley
Source: ORCID
Added: May 14, 2019

2013 journal article

High-throughput models for exposure-based chemical prioritization in the ExpoCast project.

Environmental Science and Technology, 47(15), 8479–8488.

By: J. Wambaugh*, R. Setzer*, D. Reif*, S. Gangwal*, J. Mitchell-Blackwood*, J. Arnot*, O. Joliet*, A. Frame* ...

co-author countries: Canada 🇨🇦 United States of America 🇺🇸

Contributors: J. Wambaugh*, R. Setzer*, D. Reif*, S. Gangwal*, J. Mitchell-Blackwood*, J. Arnot*, O. Joliet*, A. Frame* ...

MeSH headings : Environmental Exposure; Environmental Pollutants / classification; Models, Theoretical
Source: ORCID
Added: May 14, 2019

2013 journal article

In vitro perturbations of targets in cancer hallmark processes predict rodent chemical carcinogenesis.

Toxicological Sciences, 131(1), 40–55.

By: N. Kleinstreuer*, D. Dix*, K. Houck*, R. Kavlock*, T. Knudsen*, M. Martin*, K. Paul*, D. Reif* ...

co-author countries: United States of America 🇺🇸

Contributors: N. Kleinstreuer*, D. Dix*, K. Houck*, R. Kavlock*, T. Knudsen*, M. Martin*, K. Paul*, D. Reif* ...

author keywords: cancer hallmarks; carcinogenesis; predictive toxicology; in vitro and alternatives; bioinformatics
MeSH headings : Animals; Biomarkers, Tumor / analysis; Biomarkers, Tumor / genetics; Carcinogenicity Tests; Carcinogens / chemistry; Carcinogens / toxicity; Databases, Factual; Endpoint Determination; High-Throughput Screening Assays; In Vitro Techniques; Mice; Neoplasms / chemically induced; Neoplasms / genetics; Predictive Value of Tests; Rats; Species Specificity; Thyroid Neoplasms / chemically induced; Thyroid Neoplasms / genetics
Source: ORCID
Added: May 14, 2019

2013 journal article

Meta-analysis of toxicity and teratogenicity of 133 chemicals from zebrafish developmental toxicity studies.

Reproductive Toxicology, 41, 98–108.

By: N. Ducharme*, L. Peterson*, E. Benfenati*, D. Reif*, C. McCollum*, G. Jå*, M. Bondesson*

co-author countries: Italy 🇮🇹 Sweden 🇸🇪 United States of America 🇺🇸

Contributors: N. Ducharme*, L. Peterson*, E. Benfenati*, D. Reif*, C. McCollum*, J. Gustafsson*, M. Bondesson*

author keywords: Developmental toxicity; Zebrafish; ToxPi; Teratogen; Meta-analysis
MeSH headings : 1-Octanol / chemistry; Animals; Embryo, Nonmammalian / abnormalities; Embryo, Nonmammalian / drug effects; Teratogens / chemistry; Teratogens / toxicity; Toxicity Tests; Water / chemistry; Zebrafish
Source: ORCID
Added: May 14, 2019

2013 journal article

Perspectives on validation of high-throughput assays supporting 21st century toxicity testing.

Altex, 30(1), 51–66. http://europepmc.org/abstract/med/23338806

By: R. Judson, R. Kavlock, M. Martin, D. Reif, K. Houck, T. Knudsen, A. Richard, R. Tice ...

Contributors: R. Judson, R. Kavlock, M. Martin, D. Reif, K. Houck, T. Knudsen, A. Richard, R. Tice ...

Source: ORCID
Added: May 14, 2019

2013 journal article

Profiling 976 ToxCast Chemicals across 331 Enzymatic and Receptor Signaling Assays

Chem. Res. Toxicol., 26(6), 878–895.

By: N. Sipes*, M. Martin*, P. Kothiya*, D. Reif*, R. Judson*, A. Richard*, K. Houck*, D. Dix*, R. Kavlock*, T. Knudsen*

co-author countries: United States of America 🇺🇸

Contributors: N. Sipes*, M. Martin*, P. Kothiya*, D. Reif*, R. Judson*, A. Richard*, K. Houck*, D. Dix*, R. Kavlock*, T. Knudsen*

MeSH headings : Animals; Enzymes / metabolism; Guinea Pigs; High-Throughput Screening Assays; Humans; Membrane Transport Proteins / metabolism; Organic Chemicals / toxicity; Rats; Receptors, G-Protein-Coupled / antagonists & inhibitors; Receptors, G-Protein-Coupled / metabolism; Signal Transduction / drug effects
Source: ORCID
Added: May 14, 2019

2013 journal article

Real-time growth kinetics measuring hormone mimicry for ToxCast chemicals in T-47D human ductal carcinoma cells.

Chemical Research in Toxicology, 26(7), 1097–1107.

By: D. Rotroff*, D. Dix*, K. Houck*, R. Kavlock*, T. Knudsen*, M. Martin*, D. Reif*, A. Richard* ...

co-author countries: United States of America 🇺🇸

Contributors: D. Rotroff*, D. Dix*, K. Houck*, R. Kavlock*, T. Knudsen*, M. Martin*, D. Reif*, A. Richard* ...

MeSH headings : Breast Neoplasms / metabolism; Breast Neoplasms / pathology; Carcinoma, Ductal, Breast / metabolism; Carcinoma, Ductal, Breast / pathology; Cell Line, Tumor; Cell Proliferation / drug effects; Environmental Pollutants / toxicity; Female; High-Throughput Screening Assays; Hormones / metabolism; Humans; Kinetics; Molecular Mimicry; Receptors, Estrogen / metabolism; Time Factors; Toxicity Tests
Source: ORCID
Added: May 14, 2019

2013 article

ToxCast: Predicting Toxicity Potential Through High-Throughput Bioactivity Profiling

Houck, K. A., Richard, A. M., Judson, R. S., Martin, M. T., Reif, D. M., & Shah, I. (2013, February). High-Throughput Screening Methods in Toxicity Testing, Vol. 2, p. 1–31.

By: K. Houck*, A. Richard*, R. Judson*, M. Martin*, D. Reif* & I. Shah*

co-author countries: United States of America 🇺🇸

Contributors: K. Houck*, A. Richard*, R. Judson*, M. Martin*, D. Reif* & I. Shah*

Source: ORCID
Added: May 14, 2019

2013 journal article

ToxPi GUI: an interactive visualization tool for transparent integration of data from diverse sources of evidence.

Bioinformatics, 29(3), 402–403.

By: D. Reif*, M. Sypa*, E. Lock*, F. Wright*, A. Wilson*, T. Cathey*, R. Judson*, I. Rusyn*, Bioinformatics

co-author countries: United States of America 🇺🇸

Contributors: D. Reif*, M. Sypa*, E. Lock*, F. Wright*, A. Wilson*, T. Cathey*, R. Judson*, I. Rusyn*

MeSH headings : Computer Graphics; Software; Toxicity Tests / methods; User-Computer Interface
Source: ORCID
Added: May 14, 2019

2013 journal article

Using in vitro high throughput screening assays to identify potential endocrine-disrupting chemicals.

Environmental Health Perspectives, 121(1), 7–14.

By: D. Rotroff*, D. Dix, K. Houck, T. Knudsen, M. Martin, K. McLaurin, D. Reif*, K. Crofton* ...

co-author countries: United States of America 🇺🇸

Contributors: D. Rotroff*, D. Dix, K. Houck, T. Knudsen, M. Martin, K. McLaurin, D. Reif*, K. Crofton* ...

author keywords: androgen; endocrine; estrogen; high throughput; in vitro; ToxCast
MeSH headings : Androgens / analysis; Endocrine Disruptors / analysis; Estrogens / analysis; High-Throughput Screening Assays / methods; United States; United States Environmental Protection Agency
Source: ORCID
Added: May 14, 2019

2012 conference paper

A comparison of GE optimized neural networks and decision trees

Proceedings of the fourteenth international conference on Genetic and evolutionary computation conference companion - GECCO Companion '12, 611–614.

By: K. Hoover, R. Marceau n, T. Harris n, D. Reif n & A. Motsinger-Reif n

co-author countries: United States of America 🇺🇸

Contributors: K. Hoover, D. Reif n, R. Marceau n, T. Harris n & A. Motsinger-Reif n

Source: ORCID
Added: May 14, 2019

2012 journal article

A comparison of internal model validation methods for multifactor dimensionality reduction in the case of genetic heterogeneity

BMC Research Notes, 5(1), 623.

By: J. Gory n, H. Sweeney n, D. Reif n & A. Motsinger-Reif n

co-author countries: United States of America 🇺🇸

Contributors: J. Gory n, H. Sweeney n, D. Reif n & A. Motsinger-Reif n

MeSH headings : Algorithms; Computer Simulation; Epistasis, Genetic; Genetic Heterogeneity; Humans; Models, Genetic; Multifactor Dimensionality Reduction / standards; Research Design; Validation Studies as Topic
Source: ORCID
Added: May 14, 2019

2012 journal article

Aggregating Data for Computational Toxicology Applications: The U.S. Environmental Protection Agency (EPA) Aggregated Computational Toxicology Resource (ACToR) System.

International Journal of Molecular Sciences, 13(2), 1805–1831.

By: R. Judson*, M. Martin*, P. Egeghy*, S. Gangwal*, D. Reif*, P. Kothiya*, M. Wolf*, T. Cathey* ...

co-author countries: United States of America 🇺🇸

Contributors: R. Judson*, M. Martin*, P. Egeghy*, S. Gangwal*, D. Reif*, P. Kothiya*, M. Wolf*, T. Cathey* ...

author keywords: computational toxicology; database; hazard; exposure; high-throughput screening; ACToR; ToxCastDB; ExpoCastDB; ToxRefDB; DSSTox
MeSH headings : Algorithms; Computational Biology / methods; Databases, Factual / standards; Databases, Factual / supply & distribution; Ecotoxicology / methods; Ecotoxicology / organization & administration; Environmental Pollutants / toxicity; Humans; Software; United States; United States Environmental Protection Agency / organization & administration
Source: ORCID
Added: May 14, 2019

2012 journal article

Incorporating biological, chemical, and toxicological knowledge into predictive models of toxicity.

Toxicological Sciences, 130(2), 440–441.

By: D. Dix*, K. Houck*, R. Judson*, N. Kleinstreuer*, T. Knudsen*, M. Martin*, D. Reif*, A. Richard* ...

co-author countries: United States of America 🇺🇸

Contributors: D. Dix*, K. Houck*, R. Judson*, N. Kleinstreuer*, T. Knudsen*, M. Martin*, D. Reif*, A. Richard* ...

MeSH headings : Animals; Hazardous Substances / toxicity
Source: ORCID
Added: May 14, 2019

2012 journal article

Incorporating exposure information into the toxicological prioritization index decision support framework

Science of The Total Environment, 435-436, 316–325.

By: S. Gangwal*, D. Reif*, S. Mosher*, P. Egeghy*, J. Wambaugh*, R. Judson*, E. Hubal*

co-author countries: United States of America 🇺🇸

Contributors: S. Gangwal*, D. Reif*, S. Mosher*, P. Egeghy*, J. Wambaugh*, R. Judson*, E. Hubal*

author keywords: ExpoCast; Exposure assessment; ToxCast; Exposure metrics; Exposure prioritization; Pesticides
MeSH headings : Adolescent; Adult; Child; Child, Preschool; Decision Support Techniques; Environmental Exposure; Fruit / chemistry; Hazardous Substances / analysis; Humans; Infant; Male; Middle Aged; Models, Biological; Nutrition Surveys / statistics & numerical data; Pesticide Residues / adverse effects; Pesticide Residues / analysis; Risk Assessment / methods; Vegetables / chemistry; Young Adult
Source: ORCID
Added: May 14, 2019

2012 journal article

Update on EPA’s ToxCast Program: Providing High Throughput Decision Support Tools for Chemical Risk Management

Chem. Res. Toxicol., 25(7), 1287–1302.

By: R. Kavlock*, K. Chandler*, K. Houck*, S. Hunter*, R. Judson*, N. Kleinstreuer*, T. Knudsen*, M. Martin* ...

co-author countries: United States of America 🇺🇸

Contributors: R. Kavlock*, K. Chandler*, K. Houck*, S. Hunter*, R. Judson*, N. Kleinstreuer*, T. Knudsen*, M. Martin* ...

MeSH headings : Biological Assay; Decision Support Techniques; Environmental Pollutants / chemistry; Environmental Pollutants / toxicity; Humans; Program Development; Risk Management; United States; United States Environmental Protection Agency
Source: ORCID
Added: May 14, 2019

2012 journal article

Zebrafish developmental screening of the ToxCast™ Phase I chemical library.

Reproductive Toxicology, 33(2), 174–187.

By: S. Padilla*, D. Corum*, B. Padnos*, D. Hunter*, A. Beam*, K. Houck*, N. Sipes*, N. Kleinstreuer* ...

co-author countries: United States of America 🇺🇸

Contributors: S. Padilla*, D. Corum*, B. Padnos*, D. Hunter*, A. Beam*, K. Houck*, N. Sipes*, N. Kleinstreuer* ...

author keywords: Zebrafish; Development; Concentration-response; ToxCast (TM); Octanol-water partition coefficient; Chemical class
MeSH headings : Animals; Embryo, Nonmammalian / drug effects; Environmental Pollutants / toxicity; Models, Animal; Pesticides / toxicity; Small Molecule Libraries; Teratogens / toxicity; Toxicity Tests / methods; Zebrafish
Source: ORCID
Added: May 14, 2019

2011 journal article

Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets

Toxicology, 282(1-2), 1–15.

By: T. Knudsen*, K. Houck*, N. Sipes*, A. Singh*, R. Judson*, M. Martin*, A. Weissman*, N. Kleinstreuer* ...

co-author countries: United States of America 🇺🇸

Contributors: T. Knudsen*, K. Houck*, N. Sipes*, A. Singh*, R. Judson*, M. Martin*, A. Weissman*, N. Kleinstreuer* ...

author keywords: High-throughput screening; Computational toxicology; ToxCast; Environmental chemicals
MeSH headings : Animal Use Alternatives; Animals; Automation, Laboratory; Cell-Free System; Data Interpretation, Statistical; Databases, Factual; Environmental Pollutants / classification; Environmental Pollutants / toxicity; Enzyme Inhibitors / toxicity; High-Throughput Screening Assays; Humans; Ligands; Models, Biological; Osmolar Concentration; Pesticide Residues / toxicity; Rats; Reproducibility of Results; Toxicity Tests; United States; United States Environmental Protection Agency
Source: ORCID
Added: May 14, 2019

2011 journal article

Environmental Impact on Vascular Development Predicted by High-Throughput Screening

Environ Health Perspect, 119(11), 1596–1603.

By: N. Kleinstreuer*, R. Judson*, D. Reif*, N. Sipes*, A. Singh*, K. Chandler*, R. DeWoskin*, D. Dix*, R. Kavlock*, T. Knudsen*

co-author countries: United States of America 🇺🇸

Contributors: N. Kleinstreuer*, R. Judson*, D. Reif*, N. Sipes*, A. Singh*, K. Chandler*, R. DeWoskin*, D. Dix*, R. Kavlock*, T. Knudsen*

author keywords: angiogenesis; developmental toxicity; high-throughput screening (HTS); thalidomide; vascular development
MeSH headings : Animals; Cardiovascular System / drug effects; Cardiovascular System / embryology; Computational Biology; Databases, Factual; Environmental Pollutants / analysis; Environmental Pollutants / classification; Environmental Pollutants / immunology; Environmental Pollutants / toxicity; Female; High-Throughput Screening Assays; Humans; Male; Maternal Exposure; Mice; Models, Animal; Multivariate Analysis; Pregnancy; Rabbits; Rats; Risk Assessment; Small Molecule Libraries / analysis; Small Molecule Libraries / classification; Small Molecule Libraries / toxicity; Species Specificity; Toxicology / methods; United States; United States Environmental Protection Agency
Source: ORCID
Added: May 14, 2019

2011 journal article

Evaluation of 309 Environmental Chemicals Using a Mouse Embryonic Stem Cell Adherent Cell Differentiation and Cytotoxicity Assay

PLoS ONE, 6(6), e18540.

By: K. Chandler*, M. Barrier*, S. Jeffay*, H. Nichols*, N. Kleinstreuer*, A. Singh*, D. Reif*, N. Sipes* ...

co-author countries: United States of America 🇺🇸

Contributors: K. Chandler*, M. Barrier*, S. Jeffay*, H. Nichols*, N. Kleinstreuer*, A. Singh*, D. Reif*, N. Sipes* ...

Ed(s): A. Cooney

MeSH headings : Animals; Biological Assay; Cell Adhesion / drug effects; Cell Death / drug effects; Cell Differentiation / drug effects; Cell Line; Embryonic Stem Cells / cytology; Embryonic Stem Cells / drug effects; Endpoint Determination; Environmental Pollutants / toxicity; Male; Mice; Models, Biological; Multivariate Analysis; Toxicity Tests / methods
Source: ORCID
Added: May 14, 2019

2011 journal article

Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population.

BMC Medical Genetics, 12, 25.

By: B. Joubert*, D. Reif*, S. Edwards*, K. Leiner*, E. Hudgens*, P. Egeghy*, J. Gallagher*, E. Hubal

co-author countries: United States of America 🇺🇸

Contributors: B. Joubert*, D. Reif*, S. Edwards*, K. Leiner*, E. Hudgens*, P. Egeghy*, J. Gallagher*, E. Hubal

MeSH headings : Adolescent; Black or African American / genetics; Asthma / genetics; Child; Chromosomes, Human, Pair 11 / genetics; Cross-Sectional Studies; Female; Food Hypersensitivity / genetics; Genetic Predisposition to Disease; Glutathione S-Transferase pi / genetics; Glutathione Transferase / genetics; Haplotypes; Humans; Hypersensitivity / genetics; Hypersensitivity, Immediate / genetics; Linkage Disequilibrium; Male; Michigan; Odds Ratio; Polymorphism, Single Nucleotide; Receptors, IgE / genetics; Risk Factors; Sequence Deletion; Urban Population
Source: ORCID
Added: May 14, 2019

2011 journal article

Mechanistic indicators of childhood asthma (MICA) study: piloting an integrative design for evaluating environmental health.

BMC Public Health, 11, 344.

By: J. Gallagher*, E. Hudgens*, A. Williams*, J. Inmon*, S. Rhoney*, G. Andrews*, D. Reif*, B. Heidenfelder* ...

co-author countries: United States of America 🇺🇸

Contributors: J. Gallagher*, E. Hudgens*, A. Williams*, J. Inmon*, S. Rhoney*, G. Andrews*, D. Reif*, B. Heidenfelder* ...

MeSH headings : Adolescent; Asthma / diagnosis; Asthma / etiology; Biomarkers / blood; Child; Disease Susceptibility; Environmental Health; Environmental Monitoring / methods; Female; Genetic Predisposition to Disease / genetics; Humans; Male; Michigan; Risk Factors
Source: ORCID
Added: May 14, 2019

2011 conference paper

Optimization of grammatical evolution decision trees

Proceedings of the 13th annual conference companion on Genetic and evolutionary computation - GECCO '11, 35–36.

By: K. Hoover n, R. Marceau n, T. Harris n, N. Hardison n, D. Reif n & A. Motsinger-Reif n

co-author countries: United States of America 🇺🇸

Contributors: K. Hoover n, R. Marceau n, T. Harris n, N. Hardison n, D. Reif n & A. Motsinger-Reif n

Source: ORCID
Added: May 14, 2019

2011 journal article

Predictive model of rat reproductive toxicity from ToxCast high throughput screening.

Biology of Reproduction, 85(2), 327–339.

By: M. Martin*, T. Knudsen*, D. Reif*, K. Houck*, R. Judson*, R. Kavlock*, D. Dix*

co-author countries: United States of America 🇺🇸

Contributors: M. Martin*, T. Knudsen*, D. Reif*, K. Houck*, R. Judson*, R. Kavlock*, D. Dix*

author keywords: female reproductive tract; fertility; male reproductive tract; predictive toxicology; reproductive toxicity; toxicology
MeSH headings : Animals; Environmental Pollutants / toxicity; Gene Expression Regulation / drug effects; Male; Predictive Value of Tests; Rats; Reproduction / drug effects; Risk Assessment; Small Molecule Libraries; Toxicity Tests / methods; United States; United States Environmental Protection Agency
Source: ORCID
Added: May 14, 2019

2011 journal article

Predictive models of prenatal developmental toxicity from ToxCast high-throughput screening data.

Toxicological Sciences, 124(1), 109–127.

By: N. Sipes*, M. Martin*, D. Reif*, N. Kleinstreuer*, R. Judson*, A. Singh*, K. Chandler*, D. Dix*, R. Kavlock*, T. Knudsen*

co-author countries: United States of America 🇺🇸

Contributors: N. Sipes*, M. Martin*, D. Reif*, N. Kleinstreuer*, R. Judson*, A. Singh*, K. Chandler*, D. Dix*, R. Kavlock*, T. Knudsen*

author keywords: developmental toxicity; ToxCast; ToxRefDB; high-throughput screening; predictive models; computational models predictive toxicology
MeSH headings : Animals; Congenital Abnormalities / etiology; Databases, Factual; Embryonic Development / drug effects; Endpoint Determination; Environmental Pollutants / classification; Environmental Pollutants / toxicity; Fetal Development / drug effects; High-Throughput Screening Assays; Models, Biological; Rabbits; Rats; Species Specificity; Teratogens / classification; Teratogens / toxicity; United States; United States Environmental Protection Agency
Source: ORCID
Added: May 14, 2019

2011 journal article

Using Nuclear Receptor Activity to Stratify Hepatocarcinogens

PLoS ONE, 6(2).

By: I. Shah*, K. Houck*, R. Judson*, R. Kavlock*, M. Martin*, D. Reif*, J. Wambaugh*, D. Dix*

co-author countries: United States of America 🇺🇸

Contributors: I. Shah*, K. Houck*, R. Judson*, R. Kavlock*, M. Martin*, D. Reif*, J. Wambaugh*, D. Dix*

Ed(s): S. Wölfl

MeSH headings : Animals; Carcinogens / classification; Carcinogens / toxicity; Carcinoma, Hepatocellular / chemically induced; Carcinoma, Hepatocellular / genetics; Carcinoma, Hepatocellular / metabolism; Cells, Cultured; Constitutive Androstane Receptor; Disease Progression; Drug Evaluation, Preclinical / methods; Gene Expression / drug effects; Gene Expression Profiling; Gene Regulatory Networks / drug effects; High-Throughput Screening Assays / methods; Humans; Liver / drug effects; Liver / metabolism; Liver / pathology; Liver Neoplasms / chemically induced; Liver Neoplasms / genetics; Liver Neoplasms / metabolism; Mice; Microarray Analysis; Rats; Receptors, Cytoplasmic and Nuclear / metabolism; Receptors, Cytoplasmic and Nuclear / physiology