Works (112)

2019 | journal article

Associations between access to healthcare, environmental quality, and end-stage renal disease survival time: Proportional-hazards models of over 1,000,000 people over 14 years

PLOS ONE, 14(3).

By: M. Kosnik, D. Reif, D. Lobdell, T. Astell-Burt, X. Feng, J. Hader, J. Hoppin

Sources: Web Of Science, ORCID
Added: April 9, 2019

2019 | journal article

Determination of chemical-disease risk values to prioritize connections between environmental factors, genetic variants, and human diseases

Toxicology and Applied Pharmacology, 379, 114674.

By: M. Kosnik & D. Reif

Source: ORCID
Added: July 17, 2019

2019 | journal article

Inappropriate Citation of Vaccine Article

The Journal of Infectious Diseases, 6.

By: D. Reif, S. Chanock, K. Edwards & J. Crowe

Source: ORCID
Added: June 19, 2019

2019 | journal article

Systematic determination of the relationship between nanoparticle core diameter and toxicity for a series of structurally analogous gold nanoparticles in zebrafish

Nanotoxicology, 4, 1—15.

By: L. Truong, T. Zaikova, B. Baldock, M. Balik-Meisner, K. To, D. Reif, Z. Kennedy, J. Hutchison, R. Tanguay

Source: ORCID
Added: May 14, 2019

2018 | journal article

Characterizing the effects of missing data and evaluating imputation methods for chemical prioritization applications using ToxPi

BioData Mining, 11(1).

By: K. To, R. Fry & D. Reif

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2018 | journal article

Confirmation of high-throughput screening data and novel mechanistic insights into VDR-xenobiotic interactions by orthogonal assays

Scientific Reports, 8(1).

By: D. Mahapatra, J. Franzosa, K. Roell, M. Kuenemann, K. Houck, D. Reif, D. Fourches, S. Kullman

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2018 | journal article

Elucidating Gene-by-Environment Interactions Associated with Differential Susceptibility to Chemical Exposure.

Environmental Health Perspectives, 6(6).

By: M. Balik-Meisner, L. Truong, E. Scholl, D. La, R. Tanguay & D. Reif

Source: ORCID
Added: May 14, 2019

2018 | journal article

Neonatal mice exposed to a high-fat diet in utero influence the behaviour of their nursing dam

By: M. Baptissart, H. Lamb, K. To, C. Bradish, J. Tehrani, D. Reif, M. Cowley

Sources: NC State University Libraries, ORCID
Added: December 10, 2018

2018 | journal article

Population genetic diversity in zebrafish lines

Mammalian Genome, 29(1-2), 90–100.

By: M. Balik-Meisner, L. Truong, E. Scholl, R. Tanguay & D. Reif

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2018 | journal article

ToxPi Graphical User Interface 2.0: Dynamic exploration, visualization, and sharing of integrated data models

BMC Bioinformatics, 19(1).

By: S. Marvel, K. To, F. Grimm, F. Wright, I. Rusyn & D. Reif

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2018 | journal article

Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups

ALTEX, 35(1), 51–64.

By: W. Chiu, K. Guyton, M. Martin, D. Reif & I. Rusyn

Sources: ORCID, NC State University Libraries
Added: August 6, 2018

2017 | journal article

A New Statistical Approach to Characterize Chemical-Elicited Behavioral Effects in High-Throughput Studies Using Zebrafish

PLOS ONE, 12(1).

By: G. Zhang, L. Truong, R. Tanguay & D. Reif

Ed(s): S. Neuhauss

Source: ORCID
Added: May 14, 2019

2017 | journal article

A data-driven weighting scheme for multivariate phenotypic endpoints recapitulates zebrafish developmental cascades

Toxicology and Applied Pharmacology, 314, 109–117.

By: G. Zhang, K. Roell, L. Truong, R. Tanguay & D. Reif

Source: ORCID
Added: May 14, 2019

2017 | journal article

An Introduction to Terminology and Methodology of Chemical Synergy—Perspectives from Across Disciplines

Frontiers in Pharmacology, 8(APR).

By: K. Roell, D. Reif & A. Motsinger-Reif

Source: ORCID
Added: May 14, 2019

2017 | journal article

Embryonic exposure to TCDD impacts osteogenesis of the axial skeleton in Japanese medaka, Oryzias latipes

Toxicological Sciences, 155(2), 485–496.

By: A. Watson, A. Planchart, C. Mattingly, C. Winkler, D. Reif & S. Kullman

Source: ORCID
Added: May 14, 2019

2017 | journal article

Incorporating ToxCast and Tox21 datasets to rank biological activity of chemicals at Superfund sites in North Carolina

Environment International, 101, 19–26.

By: S. Tilley, D. Reif & R. Fry

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2017 | article

Integrating Morphological and Behavioral Phenotypes in Developing Zebrafish

The Rights and Wrongs of Zebrafish: Behavioral Phenotyping of Zebrafish. Springer International Publishing.

By: G. Zhang, L. Truong, R. Tanguay & D. Reif

Source: ORCID
Added: May 14, 2019

2017 | journal article

Lifetime substance use as a predictor of postpartum mental health

Archives of Womens Mental Health, 20(1), 189–199.

By: B. Prevatt, S. Desmarais & P. Janssen

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2017 | journal article

Transgenerational inheritance of neurobehavioral and physiological deficits from developmental exposure to benzo[a]pyrene in zebrafish

Toxicology and Applied Pharmacology, 329, 148–157.

By: A. Knecht, L. Truong, S. Marvel, D. Reif, A. Garcia, C. Lu, M. Simonich, J. Teeguarden, R. Tanguay

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2017 | review

An introduction to terminology and methodology of chemical synergy-perspectives from across disciplines

Frontiers in Pharmacology.

By: K. Roell, D. Reif & A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

2016 | journal article

A chemical-biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives

Green Chemistry, 18(16), 4407–4419.

By: F. Grimm, Y. Iwata, O. Sirenko, G. Chappell, F. Wright, D. Reif, J. Braisted, D. Gerhold ...

Sources: ORCID, NC State University Libraries
Added: August 6, 2018

2016 | journal article

Advancing Exposure Science through Chemical Data Curation and Integration in the Comparative Toxicogenomics Database

Environmental Health Perspectives, 124(10), 1592–1599.

By: C. Grondin, A. Davis, T. Wiegers, B. King, J. Wiegers, D. Reif, J. Hoppin, C. Mattingly

Sources: ORCID, NC State University Libraries
Added: August 6, 2018

2016 | journal article

Advancing Exposure Science through Chemical Data Curation and Integration in the Comparative Toxicogenomics Database.

Environmental Health Perspectives, 10.

By: C. Grondin, A. Davis, T. Wiegers, B. King, J. Wiegers, D. Reif, J. Hoppin, C. Mattingly

Source: ORCID
Added: May 14, 2019

2016 | journal article

Advancing toxicology research using in vivo high throughput toxicology with small fish models

Altex, 33(4), 435–452.

By: A. Planchart, C. Mattingly, D. Allen, P. Ceger, W. Casey, D. Hinton, J. Kanungo, S. Kullman ...

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2016 | journal article

Aggregate entropy scoring for quantifying activity across endpoints with irregular correlation structure

Reproductive Toxicology, 62, 92–99.

By: G. Zhang, S. Marvel, L. Truong, R. Tanguay & D. Reif

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2016 | journal article

Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space.

Toxicological Sciences : an Official Journal of the Society of Toxicology, 10(2), 409–409.

By: R. Judson, K. Houck, M. Martin, A. Richard, T. Knudsen, I. Shah, S. Little, J. Wambaugh ...

Source: ORCID
Added: May 14, 2019

2016 | journal article

Analysis of the effects of cell stress and cytotoxicity on in vitro assay activity across a diverse chemical and assay space

Toxicological Sciences, 152(2), 323–339.

By: R. Judson, K. Houck, M. Martin, A. Richard, T. Knudsen, I. Shah, S. Little, J. Wambaugh ...

Source: ORCID
Added: May 14, 2019

2016 | journal article

Decoupling of a neutron interferometer from temperature gradients

Review of Scientific Instruments, 87(12).

By: P. Saggu, T. Mineeva, M. Arif, D. Cory, R. Haun, B. Heacock, M. Huber, K. Li ...

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2016 | journal article

Eigenvector metabolite analysis reveals dietary effects on the association among metabolite correlation patterns, gene expression, and phenotypes

Metabolomics, 12(11).

By: C. Chialvo, R. Che, D. Reif, A. Motsinger-Reif & L. Reed

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2016 | journal article

Evolutionary and Functional Diversification of the Vitamin D Receptor-Lithocholic Acid Partnership

PLOS ONE, 11(12), e0168278.

By: E. Kollitz, G. Zhang, M. Hawkins, G. Whitfield, D. Reif & S. Kullman

Ed(s): C. Zhang

Sources: ORCID, NC State University Libraries
Added: August 6, 2018

2016 | journal article

High-throughput characterization of chemical-associated embryonic behavioral changes predicts teratogenic outcomes

Archives of Toxicology, 90(6), 1459–1470.

By: D. Reif, L. Truong, D. Mandrell, S. Marvel, G. Zhang & R. Tanguay

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2016 | journal article

Prioritizing Environmental Chemicals for Obesity and Diabetes Outcomes Research: A Screening Approach Using ToxCast™ High-Throughput Data

Environmental Health Perspectives, 124(8), 1141–1154.

By: S. Auerbach, D. Filer, D. Reif, V. Walker, A. Holloway, J. Schlezinger, S. Srinivasan, D. Svoboda ...

Sources: ORCID, NC State University Libraries
Added: August 6, 2018

2016 | journal article

Using toxcast™ data to reconstruct dynamic cell state trajectories and estimate toxicological points of departure

Environmental Health Perspectives, 124(7), 910–919.

By: I. Shah, R. Setzer, J. Jack, K. Houck, R. Judson, T. Knudsen, J. Liu, M. Martin ...

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2015 | journal article

Carcinogenicity of lindane, DDT, and 2,4-dichlorophenoxyacetic acid.

The Lancet. Oncology, 8.

By: D. Loomis, K. Guyton, Y. Grosse, G. El, V. Bouvard, L. Benbrahim-Tallaa, N. Guha, H. Mattock, K. Straif

Source: ORCID
Added: May 14, 2019

2015 | book

Computational Methods Used in Systems Biology

Systems Biology in Toxicology and Environmental Health (pp. 85–115).

By: M. Meisner & D. Reif

Source: ORCID
Added: May 14, 2019

2015 | journal article

Data-driven asthma endotypes defined from blood biomarker and gene expression data

PLoS ONE, 10(2).

By: B. George, D. Reif, J. Gallagher, C. Williams-DeVane, B. Heidenfelder, E. Hudgens, W. Jones, L. Neas, E. Cohen Hubal, S. Edwards

Source: ORCID
Added: May 14, 2019

2015 | chapter

Embracing complexity: Searching for gene-gene and gene environment interactions in genetic epidemiology

In Genomics and Proteomics: Principles, Technologies, and Applications (pp. 19–58).

By: A. Motsinger & D. Reif

Source: ORCID
Added: May 14, 2019

2015 | journal article

Food for Thought...: Toxicity testing in the 21st century beyond environmental chemicals

Altex, 32(3), 171–181.

By: C. Rovida, S. Asakura, M. Daneshian, H. Hofman-Huether, M. Leist, L. Meunier, D. Reif, A. Rossi ...

Source: ORCID
Added: May 14, 2019

2015 | journal article

Impact of low-dose oral exposure to bisphenol A (BPA) on Juvenile and adult rat exploratory and anxiety behavior: A CLARITY-BPA Consortium Study

Toxicological Sciences, 148(2), 341–354.

By: M. Rebuli, L. Camacho, M. Adonay, D. Reif, D. Aylor & H. Patisaul

Source: ORCID
Added: May 14, 2019

2015 | journal article

Molecular cloning, functional characterization, and evolutionary analysis of vitamin D receptors isolated from basal vertebrates

PLoS ONE, 10(4).

By: E. Kollitz, G. Zhang, M. Hawkins, G. Whitfield, D. Reif & S. Kullman

Source: ORCID
Added: May 14, 2019

2014 | journal article

Comparing metabolomic and pathologic biomarkers alone and in combination for discriminating Alzheimer's disease from normal cognitive aging

Acta Neuropathologica Communications, 2(1), 28.

By: A. Motsinger-Reif, H. Zhu, M. Kling, W. Matson, S. Sharma, O. Fiehn, D. Reif, D. Appleby ...

Source: ORCID
Added: May 14, 2019

2014 | journal article

Comparison of toxicity values across zebrafish early life stages and mammalian studies: Implications for chemical testing

Reproductive Toxicology, 55, 3–10.

By: N. Ducharme, D. Reif, J. Gustafsson & M. Bondesson

Source: ORCID
Added: May 14, 2019

2014 | journal article

Erratum to Incorporating human dosimetry and exposure into High-throughput in Vitro Toxicity Screening [Toxicological sciences 137, 2, (2014), 499]

Toxicological Sciences, 137(2).

By: D. Rotroff, B. Wetmore, D. Dix, S. Ferguson, H. Clewell, K. Houck, E. LeCluyse, M. Andersen ...

Source: ORCID
Added: May 14, 2019

2014 | journal article

Hierarchical dose-response modeling for high-throughput toxicity screening of environmental chemicals

Biom, 70(1), 237–246.

By: A. Wilson, D. Reif & B. Reich

Source: ORCID
Added: May 14, 2019

2014 | journal article

Multidimensional in vivo hazard assessment using zebrafish

Toxicological Sciences, 137(1), 212–233.

By: L. Truong, D. Reif, M. St, M. Geier, H. Truong & R. Tanguay

Source: ORCID
Added: May 14, 2019

2014 | journal article

Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms

Nature Biotechnology, 32(6), 583–591.

By: N. Kleinstreuer, J. Yang, E. Berg, T. Knudsen, A. Richard, M. Martin, D. Reif, R. Judson ...

Source: ORCID
Added: May 14, 2019

2014 | journal article

Predictive endocrine testing in the 21st century using in vitro assays of estrogen receptor signaling responses

Environmental Science and Technology, 48(15), 8706–8716.

By: D. Rotroff, M. Martin, D. Dix, D. Filer, K. Houck, T. Knudsen, N. Sipes, D. Reif ...

Source: ORCID
Added: May 14, 2019

2014 | journal article

Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway

Scientific Reports, 4.

By: R. Huang, S. Sakamuru, M. Martin, D. Reif, R. Judson, K. Houck, W. Casey, J. Hsieh ...

Source: ORCID
Added: May 14, 2019

2014 | journal article

Test driving ToxCast: Endocrine profiling for 1858 chemicals included in phase II

Current Opinion in Pharmacology, 19, 145–152.

By: D. Filer, H. Patisaul, T. Schug, D. Reif & K. Thayer

Source: ORCID
Added: May 14, 2019

2013 | journal article

A Computational Model Predicting Disruption of Blood Vessel Development

PLoS Comput Biol, 9(4), e1002996.

By: N. Kleinstreuer, D. Dix, M. Rountree, N. Baker, N. Sipes, D. Reif, R. Spencer, T. Knudsen

Ed(s): S. Peirce

Source: ORCID
Added: May 14, 2019

2013 | journal article

Decision tree-based method for integrating gene expression, demographic, and clinical data to determine disease endotypes

BMC Systems Biology, 7, 119.

By: C. Williams-DeVane, D. Reif, E. Cohen Hubal, P. Bushel, E. Hudgens, J. Gallagher, S. Edwards

Source: ORCID
Added: May 14, 2019

2013 | journal article

Dosimetric anchoring of In vivo and In vitro studies for perfluorooctanoate and perfluorooctanesulfonate

Toxicological Sciences, 136(2), 308–327.

By: J. Wambaugh, R. Setzer, A. Pitruzzello, J. Liu, D. Reif, N. Kleinstreuer, N. Wang, N. Sipes ...

Source: ORCID
Added: May 14, 2019

2013 | journal article

High-throughput models for exposure-based chemical prioritization in the ExpoCast project

Environmental Science and Technology, 47(15), 8479–8488.

By: J. Wambaugh, R. Setzer, D. Reif, S. Gangwal, J. Mitchell-Blackwood, J. Arnot, O. Joliet, A. Frame ...

Source: ORCID
Added: May 14, 2019

2013 | journal article

In vitro perturbations of targets in cancer hallmark processes predict rodent chemical carcinogenesis

Toxicological Sciences, 131(1), 40–55.

By: N. Kleinstreuer, D. Dix, K. Houck, R. Kavlock, T. Knudsen, M. Martin, K. Paul, D. Reif ...

Source: ORCID
Added: May 14, 2019

2013 | journal article

Meta-analysis of toxicity and teratogenicity of 133 chemicals from zebrafish developmental toxicity studies

Reproductive Toxicology, 41, 98–108.

By: N. Ducharme, L. Peterson, E. Benfenati, D. Reif, C. McCollum, G. Jå, M. Bondesson

Source: ORCID
Added: May 14, 2019

2013 | journal article

Perspectives on validation of high-throughput assays supporting 21st century toxicity testing

Altex, 30(1), 51–66.

By: R. Judson, R. Kavlock, M. Martin, D. Reif, K. Houck, T. Knudsen, A. Richard, R. Tice ...

Source: ORCID
Added: May 14, 2019

2013 | journal article

Profiling 976 ToxCast Chemicals across 331 Enzymatic and Receptor Signaling Assays

Chem. Res. Toxicol., 26(6), 878–895.

By: N. Sipes, M. Martin, P. Kothiya, D. Reif, R. Judson, A. Richard, K. Houck, D. Dix, R. Kavlock, T. Knudsen

Source: ORCID
Added: May 14, 2019

2013 | journal article

Real-time growth kinetics measuring hormone mimicry for ToxCast chemicals in T-47D human ductal carcinoma cells

Chemical Research in Toxicology, 26(7), 1097–1107.

By: D. Rotroff, D. Dix, K. Houck, R. Kavlock, T. Knudsen, M. Martin, D. Reif, A. Richard ...

Source: ORCID
Added: May 14, 2019

2013 | article

ToxCast: Predicting Toxicity Potential Through High-Throughput Bioactivity Profiling

Houck, K. A., Richard, A. M., Judson, R. S., Martin, M. T., Reif, D. M., & Shah, I. (2013, February). High-Throughput Screening Methods in Toxicity Testing. John Wiley & Sons, Inc.

By: K. Houck, A. Richard, R. Judson, M. Martin, D. Reif & I. Shah

Source: ORCID
Added: May 14, 2019

2013 | journal article

ToxPi GUI: An interactive visualization tool for transparent integration of data from diverse sources of evidence

Bioinformatics, 29(3), 402–403.

By: D. Reif, M. Sypa, E. Lock, F. Wright, A. Wilson, T. Cathey, R. Judson, I. Rusyn

Source: ORCID
Added: May 14, 2019

2013 | journal article

Using in vitro high throughput screening assays to identify potential endocrine-disrupting chemicals

Environmental Health Perspectives, 121(1), 7–14.

By: D. Rotroff, D. Dix, K. Houck, T. Knudsen, M. Martin, K. McLaurin, D. Reif, K. Crofton ...

Source: ORCID
Added: May 14, 2019

2012 | conference paper

A comparison of GE optimized neural networks and decision trees

In Proceedings of the fourteenth international conference on Genetic and evolutionary computation conference companion - GECCO Companion '12 (pp. 611–614). ACM Press.

By: K. Hoover, R. Marceau, T. Harris, D. Reif & A. Motsinger-Reif

Source: ORCID
Added: May 14, 2019

2012 | journal article

A comparison of internal model validation methods for multifactor dimensionality reduction in the case of genetic heterogeneity

BMC Research Notes, 5(1), 623.

By: J. Gory, H. Sweeney, D. Reif & A. Motsinger-Reif

Source: ORCID
Added: May 14, 2019

2012 | journal article

Aggregating Data for Computational Toxicology Applications: The U.S. Environmental Protection Agency (EPA) Aggregated Computational Toxicology Resource (ACToR) System.

International Journal of Molecular Sciences, 13(2), 1805–1831.

By: R. Judson, M. Martin, P. Egeghy, S. Gangwal, D. Reif, P. Kothiya, M. Wolf, T. Cathey ...

Source: ORCID
Added: May 14, 2019

2012 | journal article

Incorporating biological, chemical, and toxicological knowledge into predictive models of toxicity

Toxicological Sciences, 130(2), 440–441.

By: D. Dix, K. Houck, R. Judson, N. Kleinstreuer, T. Knudsen, M. Martin, D. Reif, A. Richard ...

Source: ORCID
Added: May 14, 2019

2012 | journal article

Incorporating exposure information into the toxicological prioritization index decision support framework

Science of The Total Environment, 435-436, 316–325.

By: S. Gangwal, D. Reif, S. Mosher, P. Egeghy, J. Wambaugh, R. Judson, E. Hubal

Source: ORCID
Added: May 14, 2019

2012 | journal article

Update on EPA's ToxCast program: Providing high throughput decision support tools for chemical risk management

Chemical Research in Toxicology, 25(7), 1287–1302.

By: R. Kavlock, K. Chandler, K. Houck, S. Hunter, R. Judson, N. Kleinstreuer, T. Knudsen, M. Martin ...

Source: ORCID
Added: May 14, 2019

2012 | journal article

Zebrafish developmental screening of the ToxCast™ Phase I chemical library

Reproductive Toxicology, 33(2), 174–187.

By: S. Padilla, D. Corum, B. Padnos, D. Hunter, A. Beam, K. Houck, N. Sipes, N. Kleinstreuer ...

Source: ORCID
Added: May 14, 2019

2011 | journal article

Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets

Toxicology, 282(1-2), 1–15.

By: T. Knudsen, K. Houck, N. Sipes, A. Singh, R. Judson, M. Martin, A. Weissman, N. Kleinstreuer ...

Source: ORCID
Added: May 14, 2019

2011 | journal article

Environmental Impact on Vascular Development Predicted by High-Throughput Screening

Environ Health Perspect, 119(11), 1596–1603.

By: N. Kleinstreuer, R. Judson, D. Reif, N. Sipes, A. Singh, K. Chandler, R. DeWoskin, D. Dix, R. Kavlock, T. Knudsen

Source: ORCID
Added: May 14, 2019

2011 | journal article

Evaluation of 309 Environmental Chemicals Using a Mouse Embryonic Stem Cell Adherent Cell Differentiation and Cytotoxicity Assay

PLoS ONE, 6(6), e18540.

By: K. Chandler, M. Barrier, S. Jeffay, H. Nichols, N. Kleinstreuer, A. Singh, D. Reif, N. Sipes ...

Ed(s): A. Cooney

Source: ORCID
Added: May 14, 2019

2011 | journal article

Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population

BMC Medical Genetics, 12, 25.

By: B. Joubert, D. Reif, S. Edwards, K. Leiner, E. Hudgens, P. Egeghy, J. Gallagher, E. Hubal

Source: ORCID
Added: May 14, 2019

2011 | journal article

Mechanistic Indicators of Childhood Asthma (MICA) study: Piloting an integrative design for evaluating environmental health

BMC Public Health, 11, 344.

By: J. Gallagher, E. Hudgens, A. Williams, J. Inmon, S. Rhoney, G. Andrews, D. Reif, B. Heidenfelder ...

Source: ORCID
Added: May 14, 2019

2011 | conference paper

Optimization of grammatical evolution decision trees

In Proceedings of the 13th annual conference companion on Genetic and evolutionary computation - GECCO '11 (pp. 35–36).

By: K. Hoover, R. Marceau, T. Harris, N. Hardison, D. Reif & A. Motsinger-Reif

Source: ORCID
Added: May 14, 2019

2011 | journal article

Predictive model of rat reproductive toxicity from ToxCast high throughput screening

Biology of Reproduction, 85(2), 327–339.

By: M. Martin, T. Knudsen, D. Reif, K. Houck, R. Judson, R. Kavlock, D. Dix

Source: ORCID
Added: May 14, 2019

2011 | journal article

Predictive models of prenatal developmental toxicity from ToxCast high-throughput screening data.

Toxicological Sciences, 124(1), 109–127.

By: N. Sipes, M. Martin, D. Reif, N. Kleinstreuer, R. Judson, A. Singh, K. Chandler, D. Dix, R. Kavlock, T. Knudsen

Source: ORCID
Added: May 14, 2019

2011 | journal article

Using Nuclear Receptor Activity to Stratify Hepatocarcinogens

PLoS ONE, 6(2).

By: I. Shah, K. Houck, R. Judson, R. Kavlock, M. Martin, D. Reif, J. Wambaugh, D. Dix

Ed(s): S. Wölfl

Source: ORCID
Added: May 14, 2019

2010 | journal article

Analysis of eight oil spill dispersants using rapid, in vitro tests for endocrine and other biological activity

Environmental Science and Technology, 44(15), 5979–5985.

By: R. Judson, M. Martin, D. Reif, K. Houck, T. Knudsen, D. Rotroff, M. Xia, S. Sakamuru ...

Source: ORCID
Added: May 14, 2019

2010 | journal article

Endocrine Profiling and Prioritization of Environmental Chemicals Using ToxCast Data

Environ Health Perspect, 118(12), 1714–1720.

By: D. Reif, M. Martin, S. Tan, K. Houck, R. Judson, A. Richard, T. Knudsen, D. Dix, R. Kavlock

Source: ORCID
Added: May 14, 2019

2010 | journal article

Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program.

Chemical Research in Toxicology, 23(3), 578–590.

By: M. Martin, D. Dix, R. Judson, R. Kavlock, D. Reif, A. Richard, D. Rotroff, S. Romanov ...

Source: ORCID
Added: May 14, 2019

2010 | journal article

In vitro screening of environmental chemicals for targeted testing prioritization: The toxcast project

Environmental Health Perspectives, 118(4), 485–492.

By: R. Judson, K. Houck, R. Kavlock, T. Knudsen, M. Martin, H. Mortensen, D. Reif, D. Rotroff ...

Source: ORCID
Added: May 14, 2019

2010 | journal article

Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening

Toxicological Sciences, 117(2), 348–358.

By: D. Rotroff, B. Wetmore, D. Dix, S. Ferguson, H. Clewell, K. Houck, E. Lecluyse, M. Andersen ...

Source: ORCID
Added: May 14, 2019

2010 | journal article

Research needs for community-based risk assessment: Findings from a multi-disciplinary workshop

Journal of Exposure Science and Environmental Epidemiology, 20(2), 186–195.

By: Y. Sanchez, K. Deener, E. Hubal, C. Knowlton, D. Reif & D. Segal

Source: ORCID
Added: May 14, 2019

2010 | journal article

Xenobiotic-metabolizing enzyme and transporter gene expression in primary cultures of human hepatocytes modulated by ToxCast chemicals.

Journal of Toxicology and Environmental Health - Part B: Critical Reviews, 13(2-4), 329–346.

By: D. Rotroff, A. Beam, D. Dix, A. Farmer, K. Freeman, K. Houck, R. Judson, E. LeCluyse ...

Source: ORCID
Added: May 14, 2019

2009 | journal article

A comparison of analytical methods for genetic association studies

Genet. Epidemiol., 33(8), 751–751.

By: A. Motsinger-Reif, D. Reif, T. Fanelli & M. Ritchie

Source: ORCID
Added: May 14, 2019

2009 | journal article

Comparative microarray analysis and pulmonary changes in Brown Norway rats exposed to ovalbumin and concentrated air particulates.

Toxicological Sciences, 108(1), 207–221.

By: B. Heidenfelder, D. Reif, J. Harkema, E. Cohen Hubal, E. Hudgens, L. Bramble, J. Wagner, M. Morishita ...

Source: ORCID
Added: May 14, 2019

2009 | journal article

Integrated analysis of genetic and proteomic data identifies biomarkers associated with adverse events following smallpox vaccination

Genes and Immunity, 10(2), 112–119.

By: D. Reif, A. Motsinger-Reif, B. McKinney, M. Rock, C. Je & J. Moore

Source: ORCID
Added: May 14, 2019

2009 | journal article

Profiling Chemicals Based on Chronic Toxicity Results from the U.S. EPA ToxRef Database

Environ Health Perspect, 117(3), 392–399.

By: M. Martin, R. Judson, D. Reif, R. Kavlock & D. Dix

Source: ORCID
Added: May 14, 2019

2008 | conference paper

A balanced accuracy fitness function leads to robust analysis using grammatical evolution neural networks in the case of class imbalance

In Proceedings of the 10th annual conference on Genetic and evolutionary computation - GECCO '08 (pp. 353–354). ACM Press.

By: N. Hardison, T. Fanelli, S. Dudek, D. Reif, M. Ritchie & A. Motsinger-Reif

Source: ORCID
Added: May 14, 2019

2008 | journal article

A comparison of analytical methods for genetic association studies

Genet. Epidemiol., 32(8), 767–778.

By: A. Motsinger-Reif, D. Reif, T. Fanelli & M. Ritchie

Source: ORCID
Added: May 14, 2019

2008 | journal article

Genetic basis for adverse events after smallpox vaccination

Journal of Infectious Diseases, 198(1), 16–22.

By: D. Reif, B. McKinney, A. Motsinger, S. Chanock, K. Edwards, M. Rock, J. Moore, J. Crowe

Source: ORCID
Added: May 14, 2019

2008 | journal article

Genetic basis for adverse events after smallpox vaccination (Journal of Infectious Diseases (2008) 198, (16-22))

Journal of Infectious Diseases, 198(5).

By: D. Reif, B. McKinney & A. Motsinger

Source: ORCID
Added: May 14, 2019

2007 | journal article

Evaporative cooling feature selection for genotypic data involving interactions

Bioinformatics, 23(16), 2113–2120.

By: B. McKinney, D. Reif, B. White, C. Je & J. Moore

Source: ORCID
Added: May 14, 2019

2007 | journal article

Exploratory Visual Analysis of statistical results from microarray experiments comparing high and low grade glioma.

Cancer Informatics, 5, 19–24.

By: D. Reif, M. Israel & J. Moore

Source: ORCID
Added: May 14, 2019

2007 | journal article

Linkage Disequilibrium in Genetic Association Studies Improves the Performance of Grammatical Evolution Neural Networks.

Proceedings of the ... IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology. IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, 2007, 1–8.

By: A. Motsinger, D. Reif, T. Fanelli, A. Davis & M. Ritchie

Source: ORCID
Added: May 14, 2019

2007 | conference paper

Linkage disequilibrium in genetic association studies improves the performance of grammatical evolution neural networks

In 2007 IEEE Symposium on Computational Intelligence and Bioinformatics and Computational Biology, CIBCB 2007 (pp. 1–8).

By: A. Motsinger, D. Reif, T. Fanelli, A. Davis & M. Ritchie

Source: ORCID
Added: May 14, 2019

2007 | journal article

Novel methods for detecting epistasis in pharmacogenomics studies

Pharmacogenomics, 8(9), 1229–1241.

By: A. Motsinger, M. Ritchie & D. Reif

Source: ORCID
Added: May 14, 2019

2006 | journal article

Cytokine expression patterns associated with systemic adverse events following smallpox immunization

Journal of Infectious Diseases, 194(4), 444–453.

By: B. McKinney, D. Reif, M. Rock, K. Edwards, S. Kingsmore, J. Moore, C. Je

Source: ORCID
Added: May 14, 2019

2006 | conference paper

Feature selection using a random forests classifier for the integrated analysis of multiple data types

In Proceedings of the 2006 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB'06 (pp. 171–178).

Source: ORCID
Added: May 14, 2019

2006 | article

Integrated analysis of genetic and proteomic data.

By: D. Reif & V. Libraries

Source: ORCID
Added: May 14, 2019

2006 | journal article

Machine Learning for Detecting Gene-Gene Interactions

Applied Bioinformatics, 5(2), 77–88.

By: B. McKinney, D. Reif, M. Ritchie & J. Moore

Source: ORCID
Added: May 14, 2019

2006 | conference paper

Understanding the evolutionary process of grammatical evolution neural networks for feature selection in genetic epidemiology

In Proceedings of the 2006 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB'06 (pp. 263–270). IEEE.

By: A. Motsinger, D. Reif, S. Dudek & M. Ritchie

Source: ORCID
Added: May 14, 2019

2006 | journal article

Visual analysis of statistical results from microarray studies of human breast cancer

Oncol Rep, 4(4), 1043–1047.

By: D. Reif & J. Moore

Source: ORCID
Added: May 14, 2019

2005 | conference paper

A statistical comparison of grammatical evolution strategies in the domain of human genetics

In 2005 IEEE Congress on Evolutionary Computation, IEEE CEC 2005. Proceedings (Vol. 1, pp. 676–682).

By: B. White, J. Gilbert, D. Reif & J. Moore

Source: ORCID
Added: May 14, 2019

2005 | journal article

Combinatorial Pharmacogenetics

Nat Rev Drug Discov, 4(11), 911–918.

By: R. Wilke, D. Reif & J. Moore

Source: ORCID
Added: May 14, 2019

2005 | conference paper

Exploratory visual analysis of pharmacogenomic results

In Proceedings of the Pacific Symposium on Biocomputing 2005, PSB 2005 (pp. 296–307).

By: D. Reif, S. Dudek, C. Shaffer, J. Wang & J. Moore

Source: ORCID
Added: May 14, 2019

2005 | journal article

Exploratory visual analysis of pharmacogenomic results.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing.

By: D. Reif, S. Dudek, C. Shaffer, J. Wang & J. Moore

Source: ORCID
Added: May 14, 2019

2005 | journal article

The effect of bioactive glass ceramics on the expression of bone-related genes and proteins in vitro.

Clinical Oral Implants Research, 16(1), 119–127.

By: C. Knabe, M. Stiller, G. Berger, D. Reif, R. Gildenhaar, C. Howlett, H. Zreiqat

Source: ORCID
Added: May 14, 2019

2004 | journal article

Integrated analysis of genetic, genomic and proteomic data

Expert Review of Proteomics, 1(1), 67–75.

By: D. Reif, B. White & J. Moore

Source: ORCID
Added: May 14, 2019

2003 | article

Complex Function Sets Improve Symbolic Discriminant Analysis of Microarray Data

Genetic and Evolutionary Computation — GECCO 2003. Springer Science + Business Media.

By: D. Reif, B. White, N. Olsen, T. Aune & J. Moore

Source: ORCID
Added: May 14, 2019

2003 | book

Complex function sets improve symbolic discriminant analysis of microarray data

Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 2724, pp. 2277–2287).

By: D. Reif, B. White, N. Olsen, T. Aune & J. Moore

Source: ORCID
Added: May 14, 2019

| conference paper

EXPLORATORY VISUAL ANALYSIS OF PHARMACOGENOMIC RESULTS

REIF, D. A. V. I. D. M., DUDEK, S. C. O. T. T. M., SHAFFER, C. H. R. I. S. T. I. A. N. M., WANG, J. A. N. E. Y., & MOORE, J. A. S. O. N. H. In Biocomputing 2005 - Proceedings of the Pacific Symposium. World Scientific Publishing Co. Pte. Ltd.

By: D. Reif, S. Dudek, C. Shaffer, J. Wang & J. Moore

Source: ORCID
Added: May 14, 2019

Employment

2013 - present

North Carolina State University Raleigh, NC
Associate Professor, Bioinformatics Research Center

2008 - 2012

US Environmental Protection Agency Research Triangle Park, NC
Principal Investigator (Statistician), National Center for Computational Toxicology

2006 - 2008

US Environmental Protection Agency Research Triangle Park, NC
Postdoc (Biologist), National Center for Computational Toxicology

Education

Vanderbilt University Nashville, TN
Ph.D., Human Genetics

Vanderbilt University Nashville, TN
M.S., Applied Statistics

College of William and Mary Williamsburg, VA
B.S., Biology