Works (29)

Updated: July 16th, 2023 18:35

2022 journal article

The AGMK1-9T7 cell model of neoplasia: Evolution of DNA copy-number aberrations and miRNA expression during transition from normal to metastatic cancer cells

PLOS ONE, 17(10).

By: A. Lewis*, R. Thomas*, M. Breen*, K. Peden, B. Teferedegne, G. Foseh, A. Motsinger-Reif*, D. Rotroff*, G. Lewis

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Humans; Chlorocebus aethiops; MicroRNAs / genetics; MicroRNAs / metabolism; Neoplasms / genetics; Carcinogenesis / genetics; DNA Copy Number Variations / genetics; Chromosome Aberrations; Neoplasms, Second Primary / genetics; DNA; Gene Expression Regulation, Neoplastic; Gene Expression Profiling
Source: Web Of Science
Added: February 27, 2023

2021 journal article

Adverse Cardiovascular Outcomes and Antihypertensive Treatment: A Genome‐Wide Interaction Meta‐Analysis in the International Consortium for Antihypertensive Pharmacogenomics Studies

Clinical Pharmacology & Therapeutics, 110(3), 723–732.

By: C. McDonough*, H. Warren*, J. Jack n, A. Motsinger‐Reif*, N. Armstrong*, J. Bis*, J. House*, S. Singh* ...

co-author countries: Canada 🇨🇦 Finland 🇫🇮 United Kingdom of Great Britain and Northern Ireland 🇬🇧 Italy 🇮🇹 United States of America 🇺🇸
MeSH headings : Black or African American / genetics; Aged; Antihypertensive Agents / therapeutic use; Blood Pressure / drug effects; Blood Pressure / genetics; Cardiovascular Diseases / chemically induced; Cardiovascular Diseases / genetics; Cardiovascular System / drug effects; Drug-Related Side Effects and Adverse Reactions / etiology; Drug-Related Side Effects and Adverse Reactions / genetics; Female; Genome-Wide Association Study / methods; Humans; Hypertension / drug therapy; Hypertension / genetics; Male; Middle Aged; Pharmacogenomic Testing / methods; Polymorphism, Single Nucleotide / genetics
Sources: Web Of Science, ORCID, Crossref
Added: August 23, 2021

2019 journal article

Cheminformatics approach to exploring and modeling trait-associated metabolite profiles

JOURNAL OF CHEMINFORMATICS, 11.

By: J. Ash n, M. Kuenemann n, D. Rotroff n, A. Motsinger-Reif n & D. Fourches n

co-author countries: United States of America 🇺🇸
author keywords: Metabolomics; Data mining; Cheminformatics; Molecular fragmentation; Statistics; Visualization; Chemical structure
Source: Web Of Science
Added: July 15, 2019

2018 journal article

Genetic Tools for Coronary Risk Assessment in Type 2 Diabetes: A Cohort Study From the ACCORD Clinical Trial

DIABETES CARE, 41(11), 2404–2413.

By: M. Morieri*, H. Gao*, M. Pigeyre*, H. Shah*, J. Sjaarda*, C. Mendonca*, T. Hastings*, P. Buranasupkajorn* ...

co-author countries: Canada 🇨🇦 Thailand 🇹🇭 United States of America 🇺🇸
MeSH headings : Aged; Cohort Studies; Coronary Artery Disease / diagnosis; Coronary Artery Disease / genetics; Coronary Artery Disease / prevention & control; Diabetes Mellitus, Type 2 / complications; Diabetes Mellitus, Type 2 / diagnosis; Diabetes Mellitus, Type 2 / drug therapy; Diabetes Mellitus, Type 2 / genetics; Diabetic Angiopathies / diagnosis; Diabetic Angiopathies / genetics; Diabetic Angiopathies / prevention & control; Female; Fenofibrate / administration & dosage; Genetic Association Studies; Genetic Markers; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Molecular Diagnostic Techniques; Polymorphism, Single Nucleotide; Risk Assessment; Risk Factors; Simvastatin / administration & dosage
Source: Web Of Science
Added: November 5, 2018

2018 journal article

Sphingolipid Metabolic Pathway Impacts Thiazide Diuretics Blood Pressure Response: Insights From Genomics, Metabolomics, and Lipidomics

JOURNAL OF THE AMERICAN HEART ASSOCIATION, 7(1).

co-author countries: Saudi Arabia 🇸🇦 United States of America 🇺🇸
author keywords: blood pressure; lipid metabolites; metabolomics; pharmacogenetics; thiazide diuretics
MeSH headings : Adult; Blood Pressure; Female; Genomics; Humans; Hydrochlorothiazide / therapeutic use; Hypertension / drug therapy; Lipid Metabolism; Male; Metabolic Networks and Pathways; Metabolomics; Middle Aged; Nitriles; Pharmacogenetics; Prognosis; Serine C-Palmitoyltransferase / genetics; Siloxanes; Sodium Chloride Symporter Inhibitors / therapeutic use; Sphingolipids / metabolism; Treatment Outcome
Source: Web Of Science
Added: August 6, 2018

2017 article

Assessment of potential miRNA biomarkers of VERO-cell tumorigenicity in a new line (AGMK1-9T7) of African green monkey kidney cells

Teferedegne, B., Rotroff, D. M., Macauley, J., Foseh, G., Lewis, G., Motsinger-Rief, A., & Lewis, A. M., Jr. (2017, October 4). VACCINE, Vol. 35, pp. 5503–5509.

By: B. Teferedegne*, D. Rotroff n, J. Macauley*, G. Foseh*, G. Lewis, A. Motsinger-Rief n, A. Lewis*

co-author countries: United States of America 🇺🇸
author keywords: African green monkey kidney (AGMK1-9T7) cells; Neoplastic development; Immortalization, transformation; Tumorigenic phenotype microRNA
MeSH headings : Animals; Biomarkers / metabolism; Carcinogenesis / genetics; Carcinogenesis / pathology; Cell Line; Cell Transformation, Neoplastic / genetics; Cell Transformation, Neoplastic / pathology; Chlorocebus aethiops; Female; Humans; Kidney / pathology; Mice, Nude; MicroRNAs / genetics; Neoplasms / genetics; Neoplasms / pathology; Vero Cells / pathology
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Common and rare genetic markers of lipid variation in subjects with type 2 diabetes from the ACCORD clinical trial

PeerJ, 5.

By: S. Marvel, D. Rotroff, M. Wagner, J. Buse, T. Havener, H. McLeod, A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

2017 article

Common genetic variants in neurobeachin (nbea) are associated with metformin drug response in individuals with type 2 diabetes in the accord clinical trial

Clinical Pharmacology & Therapeutics, Vol. 101, pp. S9–9.

By: D. Rotroff, S. Marvel, J. Jack, T. Havener, A. Doria, H. Shah, J. Mychaleckyi, H. McLeod ...

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Data descriptor: Targeted metabolomics and medication classification data from participants in the ADNI1 cohort

Scientific Data, 4.

By: L. St John-Williams, C. Blach, J. Toledo, D. Rotroff, S. Kim, K. Klavins, R. Baillie, X. Han ...

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Metabolic network failures in Alzheimer's disease: A biochemical road map

Alzheimers & Dementia, 13(9), 965–984.

By: J. Toledo, M. Arnold, G. Kastenmuller, R. Chang, R. Baillie, X. Han, M. Thambisetty, J. Tenenbaum ...

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

The steroid metabolome in women with premenstrual dysphoric disorder during GnRH agonist-induced ovarian suppression: Effects of estradiol and progesterone addback

Translational Psychiatry, 7.

By: T. Nguyen, J. Reuter, N. Gaikwad, D. Rotroff, H. Kucera, A. Motsinger-Reif, C. Smith, L. Nieman ...

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Tumor exome sequencing and copy number alterations reveal potential predictors of intrinsic resistance to multi-targeted tyrosine kinase inhibitors

Oncotarget, 8(70), 115114–115127.

By: N. Gillis, D. Rotroff, T. Mesa, J. Yao, Z. Chen, M. Carulli, S. Yoder, C. Walko, J. Teer, H. McLeod

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

A genetic response score for hydrochlorothiazide use insights from genomics and metabolomics integration

Hypertension, 68(3), 621-.

By: M. Shahin, Y. Gong, C. McDonough, D. Rotroff, A. Beitelshees, T. Garrett, J. Gums, A. Motsinger-Reif ...

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

A genome-wide study of lipid response to fenofibrate in Caucasians: A combined analysis of the GOLDN and ACCORD studies

Pharmacogenetics and Genomics, 26(7), 324–333.

By: M. Irvin, D. Rotroff, S. Aslibekyan, D. Zhi, B. Hidalgo, A. Motsinger-Reif, S. Marvel, V. Srinivasasainagendra ...

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Analysis of the effects of cell stress and cytotoxicity on in vitro assay activity across a diverse chemical and assay space

Toxicological Sciences, 152(2), 323–339.

By: R. Judson, K. Houck, M. Martin, A. Richard, T. Knudsen, I. Shah, S. Little, J. Wambaugh ...

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Comprehensive genomic characterization of five canine lymphoid tumor cell lines

BMC Veterinary Research, 12.

By: S. Roode, D. Rotroff, K. Richards, P. Moore, A. Motsinger-Reif, Y. Okamura, T. Mizuno, H. Tsujimoto, S. Suter, M. Breen

Source: NC State University Libraries
Added: August 6, 2018

2016 review

Embracing integrative multiomics approaches

[Review of ]. International Journal of Genomics.

By: D. Rotroff & A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Incorporating concomitant medications into genome-wide analyses for the study of complex disease and drug response

Frontiers in Genetics, 7.

By: H. Graham, D. Rotroff, S. Marvel, J. Buse, T. Havener, A. Wilson, M. Wagner, A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Maternal smoking impacts key biological pathways in newborns through epigenetic modification in Utero

BMC Genomics, 17.

By: D. Rotroff, B. Joubert, S. Marvel, S. Haberg, M. Wu, R. Nilsen, P. Ueland, W. Nystad, S. London, A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Metabolomic signatures of drug response phenotypes for ketamine and esketamine in subjects with refractory major depressive disorder: New mechanistic insights for rapid acting antidepressants

Translational Psychiatry, 6.

By: D. Rotroff, D. Corum, A. Motsinger-Reif, O. Fiehn, N. Bottrel, W. Drevets, J. Singh, G. Salvadore, R. Kaddurah-Daouk

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Pharmacometabolomic assessment of metformin in non-diabetic, African Americans

Frontiers in Pharmacology, 7.

By: D. Rotroff, N. Oki, X. Liang, S. Yee, S. Stocker, D. Corum, M. Meisner, O. Fiehn ...

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin

Nature Genetics, 48(9), 1055-.

By: K. Zhou, S. Yee, E. Seiser, N. Leeuwen, R. Tavendalel, A. Bennett, C. Groves, R. Coleman ...

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Genome-wide assessment of recurrent genomic imbalances in canine leukemia identifies evolutionarily conserved regions for subtype differentiation

Chromosome Research, 23(4), 681–708.

By: S. Roode n, D. Rotroff n, A. Avery*, S. Suter n, D. Bienzle*, J. Schiffman*, A. Motsinger-Reif n, M. Breen n

co-author countries: Canada 🇨🇦 United States of America 🇺🇸
author keywords: Leukemia; Canine; Chromosome; Comparative genomic hybridization; Comparative genomics
MeSH headings : Algorithms; Animals; Cell Transformation, Neoplastic / genetics; Chromosome Aberrations; Chromosome Mapping; Cluster Analysis; Comparative Genomic Hybridization; Conserved Sequence; DNA Copy Number Variations; Disease Models, Animal; Dogs; Evolution, Molecular; Female; Gene Dosage; Genome-Wide Association Study; Genomic Library; Genomics; Humans; In Situ Hybridization, Fluorescence; Leukemia / diagnosis; Leukemia / genetics; Leukemia / metabolism; Male
Sources: Web Of Science, Crossref
Added: August 6, 2018

2015 journal article

Integrated model of chemical perturbations of a biological pathway using 18 in vitro high-throughput screening assays for the estrogen receptor

Toxicological Sciences, 148(1), 137–154.

By: R. Judson, F. Magpantay, V. Chickarmane, C. Haskell, N. Tania, J. Taylor, M. Xia, R. Huang ...

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Genomic profiling reveals extensive heterogeneity in somatic DNA copy number aberrations of canine hemangiosarcoma

CHROMOSOME RESEARCH, 22(3), 305–319.

co-author countries: Sweden 🇸🇪 United States of America 🇺🇸
author keywords: canine; chromosome; hemangiosarcoma; comparative genomic hybridization (CGH)
MeSH headings : Animals; Breeding; Comparative Genomic Hybridization; DNA Copy Number Variations / genetics; Dog Diseases / genetics; Dogs; Gene Amplification; Gene Expression Profiling; Genetic Heterogeneity; Genome; Hemangiosarcoma / genetics; Hemangiosarcoma / veterinary; Penetrance; Vascular Endothelial Growth Factor A / genetics
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Lymphoblastoid Cell Lines Models of Drug Response: Successes and Lessons from this Pharmacogenomic Model

CURRENT MOLECULAR MEDICINE, 14(7), 833–840.

By: J. Jack*, D. Rotroff* & A. Motsinger-Reif*

author keywords: Cytotoxics; genetic association mapping; genome wide association analysis; lymphoplastoid cell lines; pharmacogenomics
MeSH headings : Cell Line, Transformed; Cost-Benefit Analysis; Genome-Wide Association Study / economics; Genome-Wide Association Study / methods; Humans; Lymphocytes / drug effects; Lymphocytes / metabolism; Models, Biological; Models, Genetic; Pharmacogenetics / economics; Pharmacogenetics / methods; Polymorphism, Single Nucleotide; RNA Interference; Reproducibility of Results; Translational Research, Biomedical / economics; Translational Research, Biomedical / methods
Source: Web Of Science
Added: August 6, 2018

2014 journal article

PGxClean: a quality control GUI for the Affymetrix DMET chip and other candidate gene studies with non-biallelic alleles

Biodata Mining, 7.

By: D. Rotroff, J. Jack, N. Campbell, S. Clark & A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Binary Classification of a Large Collection of Environmental Chemicals from Estrogen Receptor Assays by Quantitative Structure-Activity Relationship and Machine Learning Methods

JOURNAL OF CHEMICAL INFORMATION AND MODELING, 53(12), 3244–3261.

By: Q. Zang, D. Rotroff n & R. Judson

co-author countries: United States of America 🇺🇸
MeSH headings : Algorithms; Artificial Intelligence; Discriminant Analysis; Endocrine Disruptors / classification; Endocrine Disruptors / pharmacology; Environmental Monitoring; High-Throughput Screening Assays; Humans; Quantitative Structure-Activity Relationship; Receptors, Estrogen / agonists; Receptors, Estrogen / antagonists & inhibitors; Receptors, Estrogen / metabolism; Risk Assessment; Water Pollutants, Chemical / classification; Water Pollutants, Chemical / pharmacology
Source: Web Of Science
Added: August 6, 2018

2013 article

Naturally occuring canine cancers: powerful models for stimulating pharmacogenomic advancement in human medicine

Rotroff, D. M., Thomas, R., Breen, M., & Motsinger-Reif, A. A. (2013, December). PHARMACOGENOMICS, Vol. 14, pp. 1929–1931.

By: D. Rotroff n, R. Thomas n, M. Breen n & A. Motsinger-Reif n

co-author countries: United States of America 🇺🇸
author keywords: cancer; canine model; chemotherapy; clinical trials
MeSH headings : Animals; Disease Models, Animal; Dogs; Humans; Neoplasms / drug therapy; Neoplasms / pathology; Pharmacogenetics / methods
Source: Web Of Science
Added: August 6, 2018