David Nieman

Works (10)

Updated: April 25th, 2025 17:59

2023 article

Almond intake alters the acute plasma dihydroxy-octadecenoic acid (DiHOME) response to eccentric exercise

Nieman, D. C., Omar, A. M., Kay, C. D., Kasote, D. M., Sakaguchi, C. A., Lkhagva, A., … Zhang, Q. (2023, January 9). Frontiers in Nutrition, Vol. 9.

By: D. Nieman*, A. Omar*, C. Kay n , D. Kasote  n, C. Sakaguchi *, A. Lkhagva*, M. Weldemariam*, Q. Zhang *

author keywords: almonds; exercise; oxylipins; inflammation; cytokines; metabolites; (poly)phenols
topics (OpenAlex): Muscle metabolism and nutrition; Nuts composition and effects; Exercise and Physiological Responses
TL;DR: Positive effects of almond intake in improving mood state, retaining strength, decreasing muscle damage, increasing the generation of gut-derived phenolic metabolites, and altering the plasma oxylipin DiHOME response to unaccustomed eccentric exercise in untrained adults are supported. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: February 13, 2023

2023 article

Astaxanthin supplementation counters exercise-induced decreases in immune-related plasma proteins

Nieman, D. C., Woo, J., Sakaguchi, C. A., Omar, A. M., Tang, Y., Davis, K., … Zhang, Q. (2023, March 21). Frontiers in Nutrition, Vol. 10.

By: D. Nieman*, J. Woo *, C. Sakaguchi *, A. Omar*, Y. Tang *, K. Davis*, A. Pecorelli n , G. Valacchi n , Q. Zhang *

author keywords: astaxanthin; exercise; proteomics; oxylipins; inflammation; cytokines
topics (OpenAlex): Exercise and Physiological Responses; Muscle metabolism and nutrition; High Altitude and Hypoxia
TL;DR: It is supported that 4-week astaxanthin versus placebo supplementation did not counter exercise-induced increases in plasma cytokines and oxylipins but was linked to normalization of post-exercise plasma levels of numerous immune-related proteins including immunoglobulins within 24 h. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 17, 2023

2023 article

Blueberry intake elevates post-exercise anti-inflammatory oxylipins: a randomized trial

Nieman, D. C., Sakaguchi, C. A., Omar, A. M., Davis, K. L., Shaffner, C. E., Strauch, R. C., … Zhang, Q. (2023, July 24). Scientific Reports.

By: D. Nieman*, C. Sakaguchi *, A. Omar*, K. Davis*, C. Shaffner*, R. Strauch n, M. Lila n , Q. Zhang *

MeSH headings : Adult; Humans; Oxylipins; Anthocyanins; Blueberry Plants; Myalgia; Anti-Inflammatory Agents; Docosahexaenoic Acids; Eicosapentaenoic Acid
topics (OpenAlex): Eicosanoids and Hypertension Pharmacology; Pharmacology and Obesity Treatment; Exercise and Physiological Responses
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Sources: Web Of Science, NC State University Libraries
Added: August 21, 2023

2023 article

Influence of 2 Weeks of Mango Ingestion on Inflammation Resolution after Vigorous Exercise

Sakaguchi, C. A., Nieman, D. C., Omar, A. M., Strauch, R. C., Williams, J. C., Lila, M. A., & Zhang, Q. (2023, December 21). Nutrients, Vol. 16.

By: C. Sakaguchi *, D. Nieman*, A. Omar*, R. Strauch n, J. Williams *, M. Lila n , Q. Zhang *

author keywords: mangoes; exercise; inflammation; metabolites; gallotannins; oxylipins; tandem mass spectrometry
MeSH headings : Cross-Over Studies; Eating; Inflammation; Mangifera; Oxylipins; Phenols; Water; Humans; Exercise
topics (OpenAlex): High Altitude and Hypoxia; Mangiferin and Mango Extracts; Eicosanoids and Hypertension Pharmacology
TL;DR: The 2.25 h cycling bouts induced significant inflammation, but no countermeasure effect was found after 2 weeks of mango ingestion despite the elevation of mango gut-derived phenolic metabolites. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 26, 2024

2022 journal article

Enhancing the Cognitive Effects of Flavonoids With Physical Activity: Is There a Case for the Gut Microbiome?

Frontiers in Neuroscience, 16.

By: C. Cheatham *, D. Nieman*, A. Neilson n  & M. Lila n 

author keywords: age-related; cognition; neuroprotective; phenolic metabolites; prebiotic flavonoids; exercise; microbiome
topics (OpenAlex): Gut microbiota and health; Tryptophan and brain disorders; Dietary Effects on Health
TL;DR: There is a potential for combined impacts of flavonoids intake and physical exertion on cognitive function, as modulated by the gut microbiome, and that the combination of a flavonoid-rich diet and routine aerobic exercise may potentiate cognitive benefits and reduce cognitive decline in an aging population, via mechanisms mediated by the Gut microbiome. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: March 28, 2022

2021 article

Phytoecdysteroids Do Not Have Anabolic Effects in Skeletal Muscle in Sedentary Aging Mice

Lawrence, M. M., Zwetsloot, K. A., Arthur, S. T., Sherman, C. A., Huot, J. R., Badmaev, V., … Shanely, R. A. (2021, January 6). International Journal of Environmental Research and Public Health, Vol. 18.

By: M. Lawrence *, K. Zwetsloot *, S. Arthur*, C. Sherman*, J. Huot *, V. Badmaev *, M. Grace n , M. Lila n , D. Nieman*, R. Shanely *

author keywords: skeletal muscle; hypertrophy; Akt; atrogenes; 20-hydroxyecdysone
MeSH headings : Aging; Anabolic Agents; Animals; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Rats
topics (OpenAlex): Neurobiology and Insect Physiology Research; Muscle Physiology and Disorders; Muscle metabolism and nutrition
TL;DR: Data indicate that phytoecdysteroid treatment does not alter muscle mass or fiber type, nor does it activate protein synthesis signaling in the skeletal muscle of sedentary aging mice. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 7, 2021

2020 article

Blueberry and/or Banana Consumption Mitigate Arachidonic, Cytochrome P450 Oxylipin Generation During Recovery From 75-Km Cycling: A Randomized Trial

Nieman, D. C., Gillitt, N. D., Chen, G.-Y., Zhang, Q., Sha, W., Kay, C. D., … Lila, M. A. (2020, August 7). Frontiers in Nutrition, Vol. 7.

By: D. Nieman*, N. Gillitt*, G. Chen *, Q. Zhang *, W. Sha *, C. Kay n , P. Chandra  n, K. Kay*, M. Lila n 

author keywords: exercise; lipid mediators; carbohydrate; polyphenols; metabolites; inflammation; fatty acids
topics (OpenAlex): Eicosanoids and Hypertension Pharmacology; Alcohol Consumption and Health Effects; Muscle metabolism and nutrition
TL;DR: Heavy exertion evoked a transient but robust increase in plasma levels of oxylipins in cyclists, with a strong attenuation effect linked to both chronic blueberry and acute banana intake on pro-inflammatory ARA-CYP oxylIPins. (via Semantic Scholar)
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6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 21, 2020

2020 article

Postexercise Inflammasome Activation and IL-1β Production Mitigated by Flavonoid Supplementation in Cyclists

Nieman, D. C., Ferrara, F., Pecorelli, A., Woodby, B., Hoyle, A. T., Simonson, A., & Valacchi, G. (2020, September 15). International Journal of Sport Nutrition and Exercise Metabolism, Vol. 30, pp. 396–404.

By: D. Nieman*, F. Ferrara n, A. Pecorelli n , B. Woodby n, A. Hoyle*, A. Simonson*, G. Valacchi n 

author keywords: cytokines; gasdermin D; IL-18; inflammation
topics (OpenAlex): Inflammasome and immune disorders; Exercise and Physiological Responses; Adipokines, Inflammation, and Metabolic Diseases
TL;DR: The data indicate that 2-week FLAV ingestion mitigated inflammasome activation, with a corresponding decrease in IL-1β release in cyclists after a 75-km cycling time trial, and support the strategy of ingesting high amounts of FLAV to mitigate postexercise inflammation. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 9, 2020

2019 article

Immunometabolism: A Multi-Omics Approach to Interpreting the Influence of Exercise and Diet on the Immune System

Nieman, D. C., Lila, M. A., & Gillitt, N. D. (2019, January 11). Annual Review of Food Science and Technology, Vol. 10, pp. 341–363.

By: D. Nieman*, M. Lila n  & N. Gillitt*

author keywords: exercise; diet; immune function; metabolomics; lipidomics; proteomics
MeSH headings : Diet; Exercise; Humans; Immune System; Metabolism
topics (OpenAlex): Exercise and Physiological Responses; Adipose Tissue and Metabolism; Metabolomics and Mass Spectrometry Studies
TL;DR: Emerging evidence using large multi-omics data sets supports the combined intake of fruit sugars and phytochemicals by athletes during heavy exertion as an effective strategy to improve metabolic recovery, augment viral defense, and counter postexercise inflammation and immune dysfunction at the cell level. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: April 22, 2019

2019 article

Mixed Flavonoid Supplementation Attenuates Postexercise Plasma Levels of 4-Hydroxynonenal and Protein Carbonyls in Endurance Athletes

Nieman, D. C., Valacchi, G., Wentz, L. M., Ferrara, F., Pecorelli, A., Woodby, B., … Simonson, A. (2019, November 21). International Journal of Sport Nutrition and Exercise Metabolism, Vol. 30, pp. 112–119.

By: D. Nieman*, G. Valacchi n , L. Wentz *, F. Ferrara n, A. Pecorelli n , B. Woodby n, C. Sakaguchi *, A. Simonson*

author keywords: inflammation exercise; oxidative stress; peripheral blood mononuclear cells
topics (OpenAlex): Exercise and Physiological Responses; Muscle metabolism and nutrition; Adipose Tissue and Metabolism
TL;DR: Flavonoid supplementation prior to intensive exercise decreased plasma peroxidation and oxidative damage, as determined by 4-hydroxynonenal. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 6, 2020

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