Donald Freytes

Nalband, D. M., Sarker, P., Khan, S. A., & Freytes, D. O. (2023, September 16). Characterization and biological evaluation of a novel flavonoid-collagen antioxidant hydrogel with cytoprotective properties. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, Vol. 9. https://doi.org/10.1002/jbm.b.35321

Biehl, A., Colmon, R., Timofeeva, A., Gracioso Martins, A. M., Dion, G. R., Peters, K., & Freytes, D. O. (2023). Scalable and High-Throughput In Vitro Vibratory Platform for Vocal Fold Tissue Engineering Applications. BIOENGINEERING-BASEL, 10(5). https://doi.org/10.3390/bioengineering10050602

Gaffney, L. S., Fisher, M. B., & Freytes, D. O. (2023). Tendon Extracellular Matrix Promotes Myotendinous Junction Protein Expression in Engineered Muscle Tissue under Both Static and Mechanically Stimulated Culture Conditions. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2023. https://doi.org/10.1155/2023/6658543

Gracioso Martins, A. M., Biehl, A., Sze, D., & Freytes, D. O. (2022). Bioreactors for Vocal Fold Tissue Engineering. TISSUE ENGINEERING PART B-REVIEWS, 28(1), 182–205. https://doi.org/10.1089/ten.teb.2020.0285

Detwiler, A., Polkoff, K., Gaffney, L., Freytes, D. O., & Piedrahita, J. A. (2022, August 4). Donor Age and Time in Culture Affect Dermal Fibroblast Contraction in an In Vitro Hydrogel Model. TISSUE ENGINEERING PART A. https://doi.org/10.1089/ten.tea.2021.0217

Sarker, P., Nalband, D. M., Freytes, D. O., Rojas, O. J., & Khan, S. A. (2022, October 5). High-Axial-Aspect Tannic Acid Microparticles Facilitate Gelation and Injectability of Collagen-Based Hydrogels. BIOMACROMOLECULES, Vol. 10. https://doi.org/10.1021/acs.biomac.2c00916

Mora-Navarro, C., Garcia, M. E., Sarker, P., Ozpinar, E. W., Enders, J. R., Khan, S., … Freytes, D. O. (2022). Monitoring decellularization via absorbance spectroscopy during the derivation of extracellular matrix scaffolds. BIOMEDICAL MATERIALS, 17(1). https://doi.org/10.1088/1748-605X/ac361f

Biehl, A., Martins, A. M. G. M., Davis, Z. G. G., Sze, D., Collins, L., Mora-Navarro, C., … Freytes, D. O. O. (2022, December 12). Towards a standardized multi-tissue decellularization protocol for the derivation of extracellular matrix materials. BIOMATERIALS SCIENCE, Vol. 12. https://doi.org/10.1039/d2bm01012g

Ozpinar, E. W., Frey, A. L., Arthur, G. K., Mora-Navarro, C., Biehl, A., Snider, D. B., … Freytes, D. O. (2021). Dermal Extracellular Matrix-Derived Hydrogels as an In Vitro Substrate to Study Mast Cell Maturation. TISSUE ENGINEERING PART A, 27(15-16), 1008–1022. https://doi.org/10.1089/ten.tea.2020.0142

Gaffney, L. S., Davis, Z. G., Mora-Navarro, C., Fisher, M. B., & Freytes, D. O. (2021, November 2). Extracellular Matrix Hydrogels Promote Expression of Muscle-Tendon Junction Proteins. TISSUE ENGINEERING PART A, Vol. 11. https://doi.org/10.1089/ten.tea.2021.0070

Ozpinar, E. W., Frey, A. L., Cruse, G., & Freytes, D. O. (2021). Mast Cell-Biomaterial Interactions and Tissue Repair. TISSUE ENGINEERING PART B-REVIEWS, 27(6), 590–603. https://doi.org/10.1089/ten.teb.2020.0275

Martins, A. M. G., Wilkins, M. D., Ligler, F. S., Daniele, M. A., & Freytes, D. O. (2021). Microphysiological System for High-Throughput Computer Vision Measurement of Microtissue Contraction. ACS SENSORS, 6(3), 985–994. https://doi.org/10.1021/acssensors.0c02172

Mora-Navarro, C., Ozpinar, E. W., Sze, D., Martin, D. P., & Freytes, D. O. (2021). Transcriptome-targeted analysis of human peripheral blood-derived macrophages when cultured on biomaterial meshes. BIOMEDICAL MATERIALS, 16(2). https://doi.org/10.1088/1748-605X/abdbdb

Day, K., Schneible, J. D., Young, A. T., Pozdin, V. A., Driessche, G., Gaffney, L. A., … Menegatti, S. (2020). Photoinduced reconfiguration to control the protein-binding affinity of azobenzene-cyclized peptides. JOURNAL OF MATERIALS CHEMISTRY B, 8(33), 7413–7427. https://doi.org/10.1039/d0tb01189d

Nandi, S., Sommerville, L., Nellenbach, K., Mihalko, E., Erb, M., Freytes, D. O., … Brown, A. C. (2020). Platelet-like particles improve fibrin network properties in a hemophilic model of provisional matrix structural defects. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 577, 406–418. https://doi.org/10.1016/j.jcis.2020.05.088

Nandi, S., Sproul, E. P., Nellenbach, K., Erb, M., Gaffney, L., Freytes, D. O., & Brown, A. C. (2019). Platelet-like particles dynamically stiffen fibrin matrices and improve wound healing outcomes. BIOMATERIALS SCIENCE, 7(2), 669–682. https://doi.org/10.1039/c8bm01201f

Choi, J.-S., An, H.-Y., Shin, H.-S., Kim, Y.-M., & Lim, J.-Y. (2018). Enhanced tissue remodelling efficacy of adipose-derived mesenchymal stem cells using injectable matrices in radiation-damaged salivary gland model. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 12(2), E695–E706. https://doi.org/10.1002/term.2460

Liang, H., Huang, K., Su, T., Li, Z., Hu, S., Dinh, P.-U., … Cheng, K. (2018). Mesenchymal Stem Cell/Red Blood Cell-Inspired Nanoparticle Therapy in Mice with Carbon Tetrachloride-Induced Acute Liver Failure. ACS Nano, 12(7), 6536–6544. https://doi.org/10.1021/ACSNANO.8B00553

Gaffney, L., Wrona, E. A., & Freytes, D. O. (2018). [Review of Potential Synergistic Effects of Stem Cells and Extracellular Matrix Scaffolds]. ACS BIOMATERIALS SCIENCE & ENGINEERING, 4(4), 1208–1222. https://doi.org/10.1021/acsbiomaterials.7b00083

Pallotta, I., Sun, B., Wrona, E. A., & Freytes, D. O. (2017). BMP protein-mediated crosstalk between inflammatory cells and human pluripotent stem cell-derived cardiomyocytes. Journal of Tissue Engineering and Regenerative Medicine, 11(5), 1466–1478. https://doi.org/10.1002/TERM.2045

Douvaras, P., Sun, B., Wang, M., Kruglikov, I., Lallos, G., Zimmer, M., … Fossati, V. (2017). Directed Differentiation of Human Pluripotent Stem Cells to Microglia. STEM CELL REPORTS, 8(6), 1516–1524. https://doi.org/10.1016/j.stemcr.2017.04.023

Gaffney, L., Warren, P., Wrona, E. A., Fisher, M. B., & Freytes, D. O. (2017). Macrophages' role in tissue disease and regeneration. Macrophages: Origin, Functions and Biointervention, 62, 245–271.

Spiller, K. L., Wrona, E. A., Romero-Torres, S., Pallotta, I., Graney, P. L., Witherel, C. E., … Freytes, D. O. (2016). Differential gene expression in human, murine, and cell line-derived macrophages upon polarization. Experimental Cell Research, 347(1), 1–13. https://doi.org/10.1016/J.YEXCR.2015.10.017

Wrona, E. A., Peng, R., Amin, M. R., Branski, R. C., & Freytes, D. O. (2016). [Review of Extracellular Matrix for Vocal Fold Lamina Propria Replacement: A Review]. TISSUE ENGINEERING PART B-REVIEWS, 22(6), 421–429. https://doi.org/10.1089/ten.teb.2016.0015

Witherel, C. E., Graney, P. L., Freytes, D. O., Weingarten, M. S., & Spiller, K. L. (2016). Response of human macrophages to wound matrices in vitro. WOUND REPAIR AND REGENERATION, 24(3), 514–524. https://doi.org/10.1111/wrr.12423

Reeves, A. R. D., Spiller, K. L., Freytes, D. O., Vunjak-Novakovic, G., & Kaplan, D. L. (2015). Controlled release of cytokines using silk-biomaterials for macrophage polarization. Biomaterials, 73, 272–283. https://doi.org/10.1016/J.BIOMATERIALS.2015.09.027

Wrona, E. A., Peng, R., Born, H., Amin, M. R., Branski, R. C., & Freytes, D. O. (2015). Derivation and characterization of porcine vocal fold extracellular matrix scaffold. The Laryngoscope, 126(4), 928–935. https://doi.org/10.1002/LARY.25640

Badylak, S. F., Freytes, D. O., & Gilbert, T. W. (2015). Reprint of: Extracellular matrix as a biological scaffold material: Structure and function. Acta Biomaterialia, 23, S17–S26. https://doi.org/10.1016/J.ACTBIO.2015.07.016

Spiller, K. L., Freytes, D. O., & Vunjak-Novakovic, G. (2014). Macrophages Modulate Engineered Human Tissues for Enhanced Vascularization and Healing. Annals of Biomedical Engineering, 43(3), 616–627. https://doi.org/10.1007/S10439-014-1156-8

O'Neill, J. D., Anfang, R., Anandappa, A., Costa, J., Javidfar, J., Wobma, H. M., … Vunjak-Novakovic, G. (2013). Decellularization of Human and Porcine Lung Tissues for Pulmonary Tissue Engineering. The Annals of Thoracic Surgery, 96(3), 1046–1056. https://doi.org/10.1016/J.ATHORACSUR.2013.04.022

O'Neill, J. D., Freytes, D. O., Anandappa, A. J., Oliver, J. A., & Vunjak-Novakovic, G. V. (2013). The regulation of growth and metabolism of kidney stem cells with regional specificity using extracellular matrix derived from kidney. Biomaterials, 34(38), 9830–9841. https://doi.org/10.1016/J.BIOMATERIALS.2013.09.022

Freytes, D. O., Kang, J. W., Marcos-Campos, I., & Vunjak-Novakovic, G. (2012). Macrophages modulate the viability and growth of human mesenchymal stem cells. Journal of Cellular Biochemistry, 114(1), 220–229. https://doi.org/10.1002/jcb.24357

Singh, G., Javidfar, J., Costa, J., Guarrera, J. V., Miller, J., Henry, S., … Bacchetta, M. D. (2011). 549 Perfusion/Decellularization of Large Animal Lungs. The Journal of Heart and Lung Transplantation, 30(4), S184–S185. https://doi.org/10.1016/j.healun.2011.01.560

Duan, Y., Liu, Z., O’Neill, J., Wan, L. Q., Freytes, D. O., & Vunjak-Novakovic, G. (2011). Hybrid Gel Composed of Native Heart Matrix and Collagen Induces Cardiac Differentiation of Human Embryonic Stem Cells without Supplemental Growth Factors. Journal of Cardiovascular Translational Research, 4(5), 605–615. https://doi.org/10.1007/S12265-011-9304-0

Badylak, S., Freytes, D., & Gilbert, T. (2009). Extracellular matrix as a biological scaffold material: Structure and function. Acta Biomaterialia, 5(1), 1–13. https://doi.org/10.1016/j.actbio.2008.09.013

Freytes, D. O., Wan, L. Q., & Vunjak-Novakovic, G. (2009). Geometry and force control of cell function. Journal of Cellular Biochemistry, 108(5), 1047–1058. https://doi.org/10.1002/jcb.22355

Valentin, J. E., Freytes, D. O., Grasman, J. M., Pesyna, C., Freund, J., Gilbert, T. W., & Badylak, S. F. (2009). Oxygen diffusivity of biologic and synthetic scaffold materials for tissue engineering. Journal of Biomedical Materials Research Part A, 91A(4), 1010–1017. https://doi.org/10.1002/jbm.a.32328

Gilbert, T. W., Wognum, S., Joyce, E. M., Freytes, D. O., Sacks, M. S., & Badylak, S. F. (2008). Collagen fiber alignment and biaxial mechanical behavior of porcine urinary bladder derived extracellular matrix. Biomaterials, 29(36), 4775–4782. https://doi.org/10.1016/j.biomaterials.2008.08.022

Freytes, D. O., Tullius, R. S., Valentin, J. E., Stewart-Akers, A. M., & Badylak, S. F. (2008). Hydrated versus lyophilized forms of porcine extracellular matrix derived from the urinary bladder. Journal of Biomedical Materials Research Part A, 87A(4), 862–872. https://doi.org/10.1002/jbm.a.31821

Freytes, D. O., Martin, J., Velankar, S. S., Lee, A. S., & Badylak, S. F. (2008). Preparation and rheological characterization of a gel form of the porcine urinary bladder matrix. Biomaterials, 29(11), 1630–1637. https://doi.org/10.1016/j.biomaterials.2007.12.014

Freytes, D. O., Stoner, R. M., & Badylak, S. F. (2008). Uniaxial and biaxial properties of terminally sterilized porcine urinary bladder matrix scaffolds. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 84B(2), 408–414. https://doi.org/10.1002/jbm.b.30885

Freytes, D. O., Tullius, R. S., & Badylak, S. F. (2006). Effect of storage upon material properties of lyophilized porcine extracellular matrix derived from the urinary bladder. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 78B(2), 327–333. https://doi.org/10.1002/jbm.b.30491

Gilbert, T. W., Freytes, D. O., Willment, A. R., Sacks, M. S., & Badylak, S. F. (2006). Fiber architecture and biaxial mechanical behavior of porcine urinary bladder extracellular matrix. Journal of Biomechanics, 39, S391. https://doi.org/10.1016/S0021-9290(06)84582-3

Freytes, D., Rundell, A., Vandegeest, J., Vorp, D., Webster, T., & Badylak, S. (2005). Analytically derived material properties of multilaminated extracellular matrix devices using the ball-burst test. Biomaterials, 26(27), 5518–5531. https://doi.org/10.1016/j.biomaterials.2005.01.070

Badylak, S. F., Vorp, D. A., Spievack, A. R., Simmons-Byrd, A., Hanke, J., Freytes, D. O., … Nieponice, A. (2005). Esophageal Reconstruction with ECM and Muscle Tissue in a Dog Model. Journal of Surgical Research, 128(1), 87–97. https://doi.org/10.1016/j.jss.2005.03.002

Freytes, D. O., Badylak, S. F., Webster, T. J., Geddes, L. A., & Rundell, A. E. (2004). Biaxial strength of multilaminated extracellular matrix scaffolds. Biomaterials, 25(12), 2353–2361. https://doi.org/10.1016/j.biomaterials.2003.09.015