David Lunn
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Works (131)
Updated: April 5th, 2024 07:59
2024 article
Pharmacologic interventions for the treatment of equine herpesvirus-1 in domesticated horses: A systematic review
Goehring, L., Dorman, D. C., Osterrieder, K., Burgess, B. A., Dougherty, K., Gross, P., … Lunn, D. P. (2024, February 21). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 2.
author keywords: chemotherapy; equine; equine herpesvirus myeloencephalopathy; herpesvirus-1
open access via doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 22, 2024
2024 article
Updated ACVIM consensus statement on equine herpesvirus-1
Lunn, D. P., Burgess, B. A., Dorman, D. C., Goehring, L. S., Gross, P., Osterrieder, K., … Hussey, G. S. (2024, March 18). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 3.
author keywords: abortion; diagnosis; equine; equine herpesvirus myeloencephalopathy; herpesvirus-1; rhinopneumonitis; therapy; vaccination; viremia
TL;DR:
Evidence for successful vaccination against, or effective treatment of EHV-1 infection was limited, and improvements in experimental design and reporting of results are needed in future studies of this important disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 22, 2024
2023 article
Relationship between equine herpesvirus-1 viremia and abortion or equine herpesvirus myeloencephalopathy in domesticated horses: A systematic review
Soboll-Hussey, G., Dorman, D. C., Burgess, B. A., Goehring, L., Gross, P., Neinast, C., … Lunn, D. P. (2023, December 9). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 12.
author keywords: abortion; diagnosis; equine; equine herpesvirus myeloencephalopathy; herpesvirus-1; randomized clinical trial; systematic review; viremia
TL;DR:
The results of this study support that viremia is regularly present before EHM or abortion occurs, and no inferences could be made about the relationship between the occurrence of either neurological signs or abortion and the magnitude or duration of viremia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: December 18, 2023
2023 article
Vaccination for the prevention of equine herpesvirus-1 disease in domesticated horses: A systematic review and meta-analysis
Osterrieder, K., Dorman, D. C., Burgess, B. A., Goehring, L. S., Gross, P., Neinast, C., … Lunn, D. P. (2023, November 6). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 11.
author keywords: equine; equine herpesvirus myeloencephalopathy (EHM); equine herpesvirus-1 (EHV-1); vaccination
TL;DR:
It is indicated that commercial and experimental vaccines minimally reduce the incidence of clinical disease associated with EHV-1 infection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 20, 2023
2023 article
Viremia and nasal shedding for the diagnosis of equine herpesvirus-1 infection in domesticated horses
Pusterla, N., Dorman, D. C., Burgess, B. A., Goehring, L., Gross, M., Osterrieder, K., … Lunn, D. P. (2023, December 9). JOURNAL OF VETERINARY INTERNAL MEDICINE.
Contributors: N. Pusterla *, D. Dorman n, B. Burgess *, L. Goehring *, M. Gross n, K. Osterrieder *, G. Soboll Hussey *, *
author keywords: abortion; equine; equine herpesvirus myeloencephalopathy; herpesvirus-1; nasal shedding; quantitative polymerase chain reaction (qPCR); rhinopneumonitis; viremia; virus isolation
TL;DR:
Under experimental conditions, blood and nasal secretions have similar sensitivity for the detection of EHV-1 when horses are sampled on multiple consecutive days, but in observational studies detection of EHV-1 in nasal secretions was consistently more successful.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: December 18, 2023
2019 journal article
AAVMC Internship Program Guidelines 2018
Journal of Veterinary Medical Education, 46(2), 139–144.
author keywords: competency; competencies; continuing education; educational methods; graduate education; outcomes; resident; intern education; student health and well-being
MeSH headings : Animals; Education, Veterinary; Humans; Internship and Residency; United States; Universities
TL;DR:
These internship guidelines are intended to be applicable to all internships, in both academic and private practice settings, and they place particular emphasis on three aspects of internship training programs: competency-based education, intern well-being, and program outcome.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: July 1, 2019
2019 article
Report of the Fourth International Havemeyer Workshop on Equid Herpesviruses (EHV) EHV-1, EHV-2 and EHV-5
Kydd, J. H., Lunn, D. P., & Osterrieder, K. (2019, September). EQUINE VETERINARY JOURNAL, Vol. 51, pp. 565–568.
MeSH headings : Animals; Herpesviridae Infections / veterinary; Herpesvirus 1, Equid; Horse Diseases; Rhadinovirus
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 19, 2019
2016 journal article
Anti-inflammatory drugs decrease infection of brain endothelial cells with EHV-1 in vitro
EQUINE VETERINARY JOURNAL, 49(5), 629–636.
author keywords: horse; lidocaine; dexamethasone; firocoxib; EHM
MeSH headings : Animals; Anti-Inflammatory Agents / therapeutic use; Endothelial Cells / virology; Herpesviridae Infections / drug therapy; Herpesviridae Infections / veterinary; Herpesvirus 1, Equid; Horse Diseases / drug therapy; Horses; Leukocytes, Mononuclear
TL;DR:
In vitro results suggest anti-inflammatory drug therapy during EHV-1 infection and viraemia in horses could be clinically relevant and help clarify the role of adhesion molecules in this process.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 article
"Equine research - our only business': The Grayson-Jockey Club Research Foundation
Lunn, D. P., Antczak, D. F., McCue, P., Richardson, D., & Scollaly, M. (2014, July). EQUINE VETERINARY JOURNAL, Vol. 46, pp. 515–516.
MeSH headings : Animals; Foundations / organization & administration; Horse Diseases; Horses; Research / economics
TL;DR:
An analysis of the past 15 years of GJCRF research-funding patterns demonstrates some striking trends, including laminitis, colic, musculoskeletal diseases and racing injury, and infectious disease, followed by noninfectious respiratory disease and diseases of the foal.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Detection of bacteraemia and host response in healthy neonatal foals
EQUINE VETERINARY JOURNAL, 47(4), 405–409.
author keywords: horse; sepsis; transfer of immunity; passive transfer
MeSH headings : Animals; Animals, Newborn; Bacteremia / immunology; Bacteremia / microbiology; Bacteremia / veterinary; Female; Horse Diseases / immunology; Horse Diseases / microbiology; Horses; Male
TL;DR:
Positive blood cultures suggest transient bacteraemia may occur in healthy foals early in the post natal period, and age corrected normal values may be necessary to interpret cytokine concentration in diseased populations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Equine herpesvirus type 1 pUL56 modulates innate responses of airway epithelial cells
VIROLOGY, 464, 76–86.
author keywords: Equine herpesvirus-1; Respiratory epithelium; pUL56; Innate immunity
MeSH headings : Animals; Chemokines / genetics; Chemokines / immunology; Epithelial Cells / immunology; Epithelial Cells / virology; Herpesvirus 1, Equid / genetics; Herpesvirus 1, Equid / immunology; Horse Diseases / genetics; Horse Diseases / immunology; Horse Diseases / virology; Horses; Host-Pathogen Interactions; Immunity, Innate; Leukocytes, Mononuclear / immunology; Leukocytes, Mononuclear / virology; Respiratory Mucosa / cytology; Respiratory Mucosa / immunology; Respiratory Mucosa / virology; Viral Nonstructural Proteins / genetics; Viral Nonstructural Proteins / immunology
TL;DR:
Results suggest a role for EHV-1 pUL56 in modulation of antigen presentation, cytokine expression and chemotaxis at the respiratory epithelium, but not in PBMC.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Innate immune responses of airway epithelial cells to infection with Equine herpesvirus-1
VETERINARY MICROBIOLOGY, 170(1-2), 28–38.
author keywords: EHV-1; Epithelium; Innate immunity; Equine
MeSH headings : Animals; Cells, Cultured; Chemokines / genetics; Chemokines / immunology; Cytokines / genetics; Cytokines / immunology; Epithelial Cells / immunology; Epithelial Cells / virology; Gene Expression Regulation / immunology; Herpesviridae Infections / immunology; Herpesviridae Infections / veterinary; Herpesvirus 1, Equid / immunology; Horse Diseases / immunology; Horses; Host-Pathogen Interactions / immunology; Immunity, Innate / immunology; Respiratory Mucosa / immunology; Respiratory Mucosa / virology; Virus Internalization
TL;DR:
An initial characterization of the early immune response to EHV-1 at the epithelial cell barrier is provided and it is shown that, while EHv-1 maintains induction of an inflammatory response, it causes an attenuation of IFN-gamma responses and down-modulates expression of M HC-I and MHC-II, which are important molecules for antigen presentation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Science in brief: Report on the first Havemeyer workshop on infectious diseases in working equids, Addis Ababa, Ethiopia, November 2013
Equine Veterinary Journal, 47(1), 6–9.
MeSH headings : Animals; Communicable Disease Control / methods; Communicable Disease Control / standards; Communicable Diseases / economics; Communicable Diseases / epidemiology; Communicable Diseases / veterinary; Developing Countries; Equidae; Ethiopia
TL;DR:
A workshop on Infectious Diseases of Working Equids was held in Addis Ababa, Ethiopia in November 2013, attended by 35 participants representing academia, nongovernmental organisations (NGOs), governmental institutions and the World Organization for Animal Health (OIE).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
13. Climate Action
(Web of Science)
Sources: NC State University Libraries, Crossref, NC State University Libraries
Added: August 6, 2018
2013 journal article
Experimental infection with equine herpesvirus type 1 (EHV-1) induces chorioretinal lesions
VETERINARY RESEARCH, 44.
MeSH headings : Animals; Chorioretinitis / epidemiology; Chorioretinitis / pathology; Chorioretinitis / veterinary; Chorioretinitis / virology; Encephalomyelitis / epidemiology; Encephalomyelitis / pathology; Encephalomyelitis / veterinary; Encephalomyelitis / virology; Fluorescein Angiography / methods; Fluorescein Angiography / veterinary; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; Herpesviridae Infections / epidemiology; Herpesviridae Infections / pathology; Herpesviridae Infections / veterinary; Herpesviridae Infections / virology; Herpesvirus 1, Equid / isolation & purification; Horse Diseases / epidemiology; Horse Diseases / pathology; Horse Diseases / virology; Horses; Neutralization Tests / veterinary; Nose / virology; Random Allocation; Viremia / veterinary; Viremia / virology; Virus Shedding
TL;DR:
The frequency of ocular EHV-1 is 50-90% following experimental infection making this model attractive for testing future vaccines or therapeutics in an immunologically relevant age group and suggest that their pathogenesis may involve ischemic injury to the chorioretina following viremic delivery of virus to the eye, mirroring the vascular events that result in EHM.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Plasma D-Dimer Concentrations during Experimental EHV-1 Infection of Horses
JOURNAL OF VETERINARY INTERNAL MEDICINE, 27(6), 1535–1542.
author keywords: Clinical pathology; Coagulation; Fibrinolysis; Viremia
MeSH headings : Animals; DNA, Viral / chemistry; DNA, Viral / genetics; Female; Fibrin Fibrinogen Degradation Products / analysis; Fibrin Fibrinogen Degradation Products / immunology; Herpesviridae Infections / blood; Herpesviridae Infections / immunology; Herpesviridae Infections / veterinary; Herpesviridae Infections / virology; Herpesvirus 1, Equid / immunology; Horse Diseases / immunology; Horse Diseases / virology; Horses; Leukocytes, Mononuclear; Male; Polymerase Chain Reaction / veterinary; Regression Analysis; Viremia / blood; Viremia / immunology; Viremia / veterinary; Viremia / virology
TL;DR:
DD concentrations were increased for 1-8 days in the majority of infected animals, indicating that EHV-1 viremia can lead to an activation of coagulation and fibrinolysis and is associated with increases in DD concentration in horses and ponies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Proteomic Characterization of Equine Cerebrospinal Fluid
JOURNAL OF EQUINE VETERINARY SCIENCE, 34(3), 451–458.
author keywords: Equine; Cerebrospinal fluid; Proteomics; Normalized spectral abundance factor; Gene ontology
TL;DR:
Theses results provide an optimized protocol for analysis of equine CSF and lay the groundwork for future studies involving the study of equines CSF in the context of pathogenic disease states.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Equine Viral Respiratory Pathogen Surveillance at Horse Shows and Sales
Journal of Equine Veterinary Science, 33(4), 229–237.
author keywords: Horse respiratory viruses; Equine herpesvirus-1; Equine herpesvirus-4; Equine influenza virus
TL;DR:
Horses younger than 2 years had a significantly greater risk of shedding EHV-1 compared with older horses; no other significant risk factors associated with viral shedding were identified, and there is a risk of exposure to EIV, EHv-1, and EHVs at equine events, and horses and events should be managed to mitigate this risk.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Nasal Shedding of Equine Herpesvirus-1 from Horses in an Outbreak of Equine Herpes Myeloencephalopathy in Western Canada
Journal of Veterinary Internal Medicine, 26(2), 384–392.
author keywords: EHV-1; Myeloencephalitis; Neurologic; PCR
MeSH headings : Animals; Antibodies, Viral / blood; DNA, Viral / chemistry; DNA, Viral / genetics; Disease Outbreaks / veterinary; Enzyme-Linked Immunosorbent Assay / veterinary; Female; Herpesviridae Infections / epidemiology; Herpesviridae Infections / immunology; Herpesviridae Infections / veterinary; Herpesviridae Infections / virology; Herpesvirus 1, Equid / genetics; Herpesvirus 1, Equid / immunology; Herpesvirus 1, Equid / isolation & purification; Horse Diseases / epidemiology; Horse Diseases / immunology; Horse Diseases / virology; Horses; Logistic Models; Longitudinal Studies; Male; Nasal Mucosa / immunology; Nasal Mucosa / virology; Nervous System Diseases / epidemiology; Nervous System Diseases / immunology; Nervous System Diseases / veterinary; Nervous System Diseases / virology; Polymerase Chain Reaction / veterinary; Saskatchewan / epidemiology; Virus Shedding / immunology
TL;DR:
Biosecurity measures should be implemented for a minimum of 14 days beyond the onset of clinical signs of equine herpesvirus myeloencephalopathy (EHM), as animal managers cannot rely on the severity of clinicalSigns to predict the duration of EHV-1 shedding.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2012 journal article
Strain impact on equine herpesvirus type 1 (EHV-1) abortion models: Viral loads in fetal and placental tissues and foals
Vaccine, 30(46), 6564–6572.
author keywords: Horses; Equine herpesvirus-1; Abortion
MeSH headings : Abortion, Spontaneous / virology; Abortion, Veterinary / virology; Animal Structures / virology; Animals; Female; Fetus / virology; Herpesviridae Infections / veterinary; Herpesviridae Infections / virology; Herpesvirus 1, Equid / isolation & purification; Herpesvirus 1, Equid / pathogenicity; Horses; Nasal Mucosa / virology; Placenta / virology; Pregnancy; Viral Load; Viremia / virology; Virus Shedding
TL;DR:
The results demonstrate the continued importance of strain selection for abortion models, and the first report of viral load quantification using contemporary methods is reported, illustrating the infection risk posed to other horses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2012 journal article
Third International Havemeyer Workshop on Equine Herpesvirus type 1
Equine Veterinary Journal, 44(5), 513–517.
MeSH headings : Animals; Herpesviridae Infections / immunology; Herpesviridae Infections / prevention & control; Herpesviridae Infections / veterinary; Herpesviridae Infections / virology; Herpesvirus 1, Equid / classification; Herpesvirus 1, Equid / immunology; Herpesvirus 1, Equid / physiology; Horse Diseases / epidemiology; Horse Diseases / virology; Horses; Internationality; Risk Factors; Viral Vaccines / immunology; Virulence
Source: Crossref
Added: July 27, 2019
2012 journal article
Use of CSF biomarkers as a model to study EHM
Journal of Equine Veterinary Science, 32(10), S64–S65.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2011 journal article
Cardiac Troponin I Concentrations in Ponies Challenged with Equine Influenza Virus
Journal of Veterinary Internal Medicine, 25(2), 339–344.
author keywords: cTnI; EIV; Myocardial damage
MeSH headings : Animals; Female; Heart Diseases / blood; Heart Diseases / diagnosis; Heart Diseases / veterinary; Heart Diseases / virology; Horse Diseases / blood; Horse Diseases / diagnosis; Horse Diseases / virology; Horses; Influenza A Virus, H3N8 Subtype; Influenza Vaccines / administration & dosage; Male; Orthomyxoviridae Infections / blood; Orthomyxoviridae Infections / diagnosis; Orthomyxoviridae Infections / veterinary; Troponin I / blood; Virus Shedding
TL;DR:
This study demonstrated no evidence of severe myocardial necrosis secondary to EIV challenge with 10⁸ EID₅₀ EIV A/eq/Kentucky/91 in these sedentary ponies, but transient increases in cTnI suggest that mildMyocardial damage may occur.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2011 journal article
Effect of Long-Term Fluticasone Treatment on Immune Function in Horses with Heaves
Journal of Veterinary Internal Medicine, 25(3), 549–557.
author keywords: Aerosolized; Horse; Inhaled corticosteroids; Recurrent airway obstruction
MeSH headings : Androstadienes / administration & dosage; Androstadienes / therapeutic use; Animal Husbandry; Animals; Anti-Inflammatory Agents / administration & dosage; Anti-Inflammatory Agents / therapeutic use; Drug Administration Schedule; Female; Fluticasone; Gene Expression Regulation / drug effects; Horse Diseases / drug therapy; Horse Diseases / immunology; Horses; Immunoglobulin G / blood; Immunoglobulin G / classification; Lymphocyte Subsets / physiology; Male; Neutrophils / metabolism; Pulmonary Disease, Chronic Obstructive / drug therapy; Pulmonary Disease, Chronic Obstructive / immunology; Pulmonary Disease, Chronic Obstructive / veterinary; Tetanus Toxoid / immunology; Time Factors; Viral Vaccines
TL;DR:
The treatment of heaves-affected horses with inhaled fluticasone at therapeutic dosages for 11 months has no significant detectable effect on innate and adaptive immune parameters studied, suggesting that prolonged administration of flutic asone would not compromise the systemic immune response to pathogens nor vaccination in adult horses.
(via Semantic Scholar)
Source: Crossref
Added: July 27, 2019
2011 chapter
Equine Health and Disease
In W. McIlwraith & B. Rollin (Eds.), Equine Welfare (pp. 59–70). Chichester, UK: Blackwell Publishing.
Ed(s): W. McIlwraith & B. Rollin
Source: NC State University Libraries
Added: August 4, 2019
2011 journal article
Evaluation of immune responses following infection of ponies with an EHV-1 ORF1/2 deletion mutant
Veterinary Research, 42(1), 23.
MeSH headings : Adaptive Immunity; Animals; Antibodies, Viral / blood; Cytokines / blood; Cytokines / genetics; Enzyme-Linked Immunosorbent Assay / veterinary; Female; Herpesviridae Infections / immunology; Herpesviridae Infections / veterinary; Herpesviridae Infections / virology; Herpesvirus 1, Equid / genetics; Herpesvirus 1, Equid / immunology; Herpesvirus 1, Equid / metabolism; Horse Diseases / immunology; Horse Diseases / virology; Horses; Immunity, Innate; Male; Nasal Mucosa / virology; RNA, Messenger / analysis; Random Allocation; Viral Proteins / genetics; Viral Proteins / metabolism; Viremia / immunology; Viremia / veterinary; Viremia / virology; Virus Shedding
TL;DR:
It is found that infection of ponies with EHV-1 leads to modulation of immune responses, which are correlated with disease pathogenesis, and that the ORF1/2 genes are of importance for disease outcome and modulation of cytokine responses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2011 chapter
Viral respiratory diseases of the older foal
In A. McKinnon, E. L. Squires, W. Vaala, & J. Voss (Eds.), Equine Reproduction (2nd ed., pp. 720–727). Chichester, UK: Wiley-Blackwell.
Ed(s): A. McKinnon, E. Squires, W. Vaala & J. Voss
Source: NC State University Libraries
Added: August 4, 2019
2010 journal article
Control of EHV-1 viremia and nasal shedding by commercial vaccines
Vaccine, 28(32), 5203–5211.
author keywords: EHV-1; Horses; Immunity; Vaccination
MeSH headings : Animals; Antibodies, Neutralizing / blood; Antibodies, Viral / blood; Antibody Formation; Female; Herpesviridae Infections / immunology; Herpesviridae Infections / prevention & control; Herpesviridae Infections / veterinary; Herpesvirus 1, Equid / immunology; Horse Diseases / immunology; Horse Diseases / prevention & control; Horses / immunology; Immunization Schedule; Neutralization Tests; Nose / immunology; Single-Blind Method; Viral Vaccines / immunology; Viremia / prevention & control; Viremia / veterinary; Virus Shedding
TL;DR:
It is demonstrated that both commercial vaccines significantly suppressed EHV-1 disease and nasal viral shedding, and one vaccine suppressed days of viremia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2010 journal article
Equine herpesvirus-1 infected peripheral blood mononuclear cell subpopulations during viremia
Veterinary Microbiology, 149(1-2), 40–47.
author keywords: EHV-1; Quantitative PCR; Viremia; Cell subsets
MeSH headings : Animals; B-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / immunology; DNA, Viral / blood; Female; Herpesviridae Infections / immunology; Herpesviridae Infections / veterinary; Herpesviridae Infections / virology; Herpesvirus 1, Equid / immunology; Horse Diseases / immunology; Horse Diseases / virology; Horses / virology; Leukocytes, Mononuclear / immunology; Leukocytes, Mononuclear / virology; Male; Polymerase Chain Reaction / methods; Polymerase Chain Reaction / veterinary; Viremia / immunology; Viremia / veterinary; Viremia / virology
TL;DR:
Which PBMC subpopulations are infected during viremia and may therefore play a role in transmitting the virus to the vascular endothelium of the spinal cord or pregnant uterus are identified and differ from what has been reported in in vitro studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2010 journal article
Infection of central nervous system endothelial cells by cell-associated EHV-1
Veterinary Microbiology, 148(2-4), 389–395.
author keywords: CNS; Endothelium; Horses; EHV-1
MeSH headings : Animals; Antibodies, Neutralizing / immunology; Antibodies, Viral / immunology; Brain / cytology; Carotid Arteries / cytology; Cells, Cultured; Central Nervous System / cytology; Endothelial Cells / pathology; Endothelial Cells / virology; Herpesviridae Infections / immunology; Herpesviridae Infections / veterinary; Herpesviridae Infections / virology; Herpesvirus 1, Equid / immunology; Herpesvirus 1, Equid / pathogenicity; Horse Diseases / immunology; Horse Diseases / pathology; Horse Diseases / virology; Horses / virology; Leukocytes, Mononuclear / pathology; Leukocytes, Mononuclear / virology
TL;DR:
A model of CNS endothelial cell infection using EHV-1 infected, autologous PBMC was developed, consistent with cell-to-cell spread of EHv-1 infection from leucocytes to ECs, demonstrating the importance of this mode of infection in the presence of antibody, and the utility of this model for study of cellular interactions in EHVs infection of ECs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2010 journal article
Low-dose DNA vaccination into the submandibular lymph nodes in ponies
Veterinary Record, 167(8), 302–303.
MeSH headings : Animals; Cost-Benefit Analysis; Dose-Response Relationship, Immunologic; Hemagglutinin Glycoproteins, Influenza Virus / genetics; Hemagglutinin Glycoproteins, Influenza Virus / immunology; Horse Diseases / prevention & control; Horses; Immunotherapy / veterinary; Influenza A Virus, H3N8 Subtype / genetics; Influenza A Virus, H3N8 Subtype / immunology; Lymph Nodes; Orthomyxoviridae Infections / prevention & control; Pilot Projects; Random Allocation; Vaccination / methods; Vaccination / veterinary; Vaccines, DNA / administration & dosage; Vaccines, DNA / immunology
TL;DR:
The ability to elicit an antigen-specific immune response in horses is desirable, either for protecting them against a pathogen, or for immunomodulation as a means of treating hypersensitivity diseases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2010 journal article
Molecular Investigation of the Viral Kinetics of Equine Herpesvirus-1 in Blood and Nasal Secretions of Horses after Corticosteroid-Induced Recrudescence of Latent Infection
Journal of Veterinary Internal Medicine, 24(5), 1153–1157.
author keywords: EHV-1; Reactivation; Transmission
MeSH headings : Adrenal Cortex Hormones / pharmacology; Animals; Dexamethasone / pharmacology; Herpesvirus 1, Equid / physiology; Horse Diseases / blood; Horse Diseases / immunology; Horse Diseases / virology; Horses; Male; Mucus / virology; Time Factors; Virus Latency / drug effects; Virus Replication / physiology
TL;DR:
EHV-1 was successfully reactivated after corticosteroid administration in latently infected horses, however, transmission of reactivated virus to sentinel horses was unsuccessful.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2010 journal article
Report of the Second Havemeyer EHV-1 Workshop, Steamboat Springs, Colorado, USA, September 2008
Equine Veterinary Journal, 42(6), 572–575.
author keywords: horse; EHV-1; report; Havemeyer Foundation; equine herpesvirus myeloencephalopathy
MeSH headings : Animals; Colorado; Herpesviridae Infections / veterinary; Herpesvirus 1, Equid; Horse Diseases / epidemiology; Horse Diseases / virology; Horses
TL;DR:
This report summarises the findings of the Second Havemeyer EHV-1 Workshop, which was held in Steamboat Springs, Colorado, USA in September 2008 and summarizes the key advances identified during and since the meeting.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2009 journal article
Comparison of Four Methods to Quantify Equid Herpesvirus 1 Load by Real-Time Polymerase Chain Reaction in Nasal Secretions of Experimentally and Naturally Infected Horses
Journal of Veterinary Diagnostic Investigation, 21(6), 836–840.
author keywords: Equid herpesvirus 1; horses; nasal secretions; real-time polymerase chain reaction; viral load quantitation methods
MeSH headings : Animals; Herpesviridae Infections / diagnosis; Herpesviridae Infections / genetics; Herpesviridae Infections / veterinary; Herpesvirus 1, Equid / genetics; Herpesvirus 1, Equid / isolation & purification; Horse Diseases / diagnosis; Horse Diseases / genetics; Horse Diseases / virology; Horses; Male; Nasal Mucosa / virology; Nose / virology; Orchiectomy / veterinary; Polymerase Chain Reaction / methods; RNA, Viral / blood; Viral Load / veterinary
TL;DR:
Comparisons of 4 methods to quantify Equid herpesvirus 1 (EHV-1) by real-time polymerase chain reaction (PCR) in nasal secretions from experimentally and naturally infected horses showed that all 4 calculation methods yielded comparable results, and that the different methods were significantly correlated with each other.
(via Semantic Scholar)
Source: Crossref
Added: July 27, 2019
2009 journal article
Equine Herpesvirus-1 Consensus Statement
Journal of Veterinary Internal Medicine, 23(3), 450–461.
author keywords: Abortion; Horse; Immunology; Infectious diseases; Myeloencephalopathy; Respiratory tract; Viral
MeSH headings : Animals; Central Nervous System Diseases / veterinary; Central Nervous System Diseases / virology; Disease Outbreaks / prevention & control; Disease Outbreaks / veterinary; Female; Herpesviridae Infections / epidemiology; Herpesviridae Infections / prevention & control; Herpesviridae Infections / veterinary; Herpesvirus 1, Equid / classification; Herpesvirus 1, Equid / physiology; Horse Diseases / epidemiology; Horse Diseases / virology; Horses; Pregnancy; Pregnancy Complications, Infectious / veterinary; Pregnancy Complications, Infectious / virology; Risk Factors; Viral Vaccines / immunology
TL;DR:
This consensus statement draws together current knowledge in the areas of pathogenesis, strain variation, epidemiology, diagnostic testing, vaccination, outbreak prevention and control, and treatment of herpesvirus-1.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2009 journal article
Immune responses of Asian elephants (Elephas maximus) to commercial tetanus toxoid vaccine
Veterinary Immunology and Immunopathology, 133(2-4), 287–289.
author keywords: Asian elephant; Elephas maximus; Tetanus toxoid; Vaccination; Vaccine titer; Immunosenescence
MeSH headings : Age Factors; Animal Husbandry / methods; Animals; Animals, Zoo / immunology; Antibodies, Bacterial / biosynthesis; Antibodies, Bacterial / blood; Clostridium tetani / immunology; Elephants / immunology; Enzyme-Linked Immunosorbent Assay / veterinary; Female; Immunization Schedule; Immunization, Secondary / veterinary; Male; Species Specificity; Tetanus / immunology; Tetanus / prevention & control; Tetanus / veterinary; Tetanus Toxoid / administration & dosage; Time Factors
TL;DR:
The great majority of elephants had titers prior to booster vaccination, and following revaccination all elephants demonstrated anamnestic increases in titers, indicating that this species does respond to tetanus vaccination.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2009 journal article
Onset and duration of immunity to equine influenza virus resulting from canarypox-vectored (ALVAC®) vaccination
Veterinary Immunology and Immunopathology, 135(1-2), 100–107.
author keywords: ALVAC (R)-influenza vaccination; Horse; Influenza virus
MeSH headings : Animals; Antibodies, Viral / blood; Antibody Formation / immunology; Canarypox virus; Horse Diseases / immunology; Horse Diseases / prevention & control; Horse Diseases / virology; Horses / immunology; Influenza A Virus, H3N8 Subtype / immunology; Influenza Vaccines / immunology; Influenza Vaccines / therapeutic use; Male; Orthomyxoviridae Infections / immunology; Orthomyxoviridae Infections / prevention & control; Orthomyxoviridae Infections / veterinary; Vaccines, Synthetic / immunology; Vaccines, Synthetic / therapeutic use; Virus Shedding / immunology
TL;DR:
The results of this study clearly demonstrate the early onset, and 6-month duration of protective immunity resulting from ALVAC-influenza vaccination against challenge with American lineage equine influenza viruses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2009 journal article
Sensitization of skin mast cells with IgE antibodies to Culicoides allergens occurs frequently in clinically healthy horses
Veterinary Immunology and Immunopathology, 132(1), 53–61.
author keywords: IgE; IgG; Allergy; Sensitization; Horse
MeSH headings : Aging; Allergens / immunology; Animals; Antibodies, Anti-Idiotypic / immunology; Basophils / immunology; Ceratopogonidae / immunology; Female; Histamine / blood; Horse Diseases / diagnosis; Horse Diseases / immunology; Horses; Hypersensitivity / diagnosis; Hypersensitivity / immunology; Hypersensitivity / veterinary; Immunization; Immunoglobulin E / immunology; Immunoglobulin G / immunology; Insect Proteins / immunology; Intradermal Tests; Male; Mast Cells / immunology; Skin / immunology
TL;DR:
IgE was the major immunoglobulin involved in the sensitization of mast cells and basophils in horses at various ages and results are useful to diagnose Culicoides-induced allergy only in horses with allergic conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 4, 2019
2009 journal article
The Effect of Age on the Immune Response of Horses to Vaccination
Journal of Comparative Pathology, 142, S85–S90.
author keywords: geriatric; horse; immunosenescence; vaccination
MeSH headings : Age Factors; Aging / immunology; Animals; Horse Diseases / immunology; Horses / immunology; Immunization, Secondary; Immunologic Memory / immunology; Influenza A Virus, H3N8 Subtype / immunology; Influenza Vaccines / immunology; Orthomyxoviridae Infections / immunology; Rabies Vaccines / immunology; Vaccination / veterinary
TL;DR:
Healthy aged horses mounted a primary immune response to rabies vaccine that was similar to that of younger adult horses, however, aged horses had a significantly reduced anamnestic response to influenza vaccination in comparison with the younger adult Horses, even though the pre-vaccination antibody titres of aged horses were higher.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2009 chapter
The Equine Immune System
In S. Reed, W. Bayly, D. Sellon, & W. B. Saunders (Eds.), Equine Internal Medicine (3rd ed., pp. 2–56).
Ed(s): S. Reed, W. Bayly, D. Sellon & W. Saunders
Source: NC State University Libraries
Added: August 4, 2019
2009 journal article
Vaccination of ponies with the IE gene of EHV-1 in a recombinant modified live vaccinia vector protects against clinical and virological disease
Veterinary Immunology and Immunopathology, 135(1-2), 108–117.
author keywords: EHV-1; Horses; Immediate early gene; Vaccination; IFN gamma
MeSH headings : Animals; Antibodies, Neutralizing / blood; Female; Genes, Immediate-Early / genetics; Genes, Immediate-Early / immunology; Genotype; Herpesviridae Infections / immunology; Herpesviridae Infections / prevention & control; Herpesviridae Infections / veterinary; Herpesvirus 1, Equid / genetics; Herpesvirus 1, Equid / immunology; Herpesvirus Vaccines / genetics; Herpesvirus Vaccines / immunology; Herpesvirus Vaccines / therapeutic use; Horse Diseases / immunology; Horse Diseases / prevention & control; Horses / immunology; Horses / virology; Interferon-gamma / blood; Male; Vaccines, Synthetic / genetics; Vaccines, Synthetic / immunology; Vaccines, Synthetic / therapeutic use; Vaccinia; Viremia / immunology; Viremia / veterinary
TL;DR:
This is an important study showing that vaccination of ponies with the EHV-1 IE protein provides not only reduction in clinical disease but also reduction of cell associated viremia, which is a prerequisite for the prevention of abortion and neurological disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2008 chapter
Equine herpesvirus myeloencephalopathy
In N. E. Robinson (Ed.), Current Therapy in Equine Medicine (6th ed., pp. 177–181). St. Louis: Saunders.
Ed(s): N. Robinson
Source: NC State University Libraries
Added: August 4, 2019
2008 chapter
Equine respiratory viruses
In B. Smith (Ed.), Large Animal Medicine (6th ed., pp. 542–550). St. Louis: Elsevier.
Ed(s): B. Smith
Source: NC State University Libraries
Added: August 4, 2019
2008 journal article
Report of the 3rd Havemeyer workshop on allergic diseases of the Horse, Hólar, Iceland, June 2007
Veterinary Immunology and Immunopathology, 126(3-4), 351–361.
MeSH headings : Airway Obstruction / genetics; Airway Obstruction / immunology; Airway Obstruction / veterinary; Animals; Genetic Predisposition to Disease / genetics; Horse Diseases / genetics; Horse Diseases / immunology; Horse Diseases / pathology; Horses; Hypersensitivity / genetics; Hypersensitivity / immunology; Hypersensitivity / pathology; Hypersensitivity / veterinary; Insect Bites and Stings / immunology; Insect Bites and Stings / veterinary
TL;DR:
The 3rd workshop on Allergic Diseases of the Horse was held in Hólar, Iceland, in June 2007 and focussed on immunological and genetic aspects of IBH and RAO and summarizes important issues discussed at the workshop.
(via Semantic Scholar)
Source: Crossref
Added: July 27, 2019
2008 journal article
The Effect of Age on Serum Antibody Titers after Rabies and Influenza Vaccination in Healthy Horses
Journal of Veterinary Internal Medicine, 22(3), 654–661.
author keywords: equine; geriatric; immune response; immunosenescence
MeSH headings : Aging / blood; Aging / immunology; Animals; Antibodies, Viral / blood; Female; Horse Diseases / blood; Horse Diseases / genetics; Horse Diseases / immunology; Horses / blood; Horses / immunology; Immunoglobulin A / blood; Immunoglobulin G / blood; Influenza Vaccines / immunology; Male; Orthomyxoviridae Infections / immunology; Orthomyxoviridae Infections / veterinary; Rabies / immunology; Rabies / veterinary; Rabies Vaccines / immunology; Seasons; Selenium / blood; Sex Characteristics; Thyroxine / blood; Time Factors; Triiodothyronine / blood; Vitamin E / blood; alpha-MSH / blood
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 4, 2019
2008 journal article
The role of leukocyte biology in laminitis
Veterinary Immunology and Immunopathology, 129(3-4), 158–160.
author keywords: Laminitis; Horse; Leukocyte; Inflammation
MeSH headings : Animals; Foot Diseases / immunology; Foot Diseases / pathology; Foot Diseases / veterinary; Hoof and Claw; Horse Diseases / immunology; Horse Diseases / pathology; Horses; Inflammation / immunology; Inflammation / pathology; Inflammation / veterinary; Leukocytes / cytology; Leukocytes / immunology
TL;DR:
The role of leukocytes in the initiation of laminitis, or as an intermediary factor, is currently being investigated using a limited array of models, and future studies require both new reagent and model systems if to clearly define how leukocyte propagate this disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2007 chapter
Equine Influenza Infection
In Equine Infectious Diseases (pp. 124–134).
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2007 journal article
Further analysis of anti-human leukocyte mAbs with reactivity to equine leukocytes by two-colour flow cytometry and immunohistochemistry
Veterinary Immunology and Immunopathology, 119(1-2), 92–99.
author keywords: horse; immunology; leukocyte differentiation; flow cytometry; immunohistochemistry
MeSH headings : Animals; Antibodies, Monoclonal / immunology; Antigens, CD / analysis; Antigens, CD / immunology; Cross Reactions; Flow Cytometry / methods; Horses / immunology; Humans; Immunohistochemistry; Leukocytes / immunology
TL;DR:
This additional study tested for the reliability of the results obtained, and to obtain further information on the positive populations of lymphocytes, using many of the positive mAbs and a few questionable ones from the first part of the study.
(via Semantic Scholar)
Source: Crossref
Added: July 27, 2019
2007 journal article
Screening of anti-human leukocyte monoclonal antibodies for reactivity with equine leukocytes
Veterinary Immunology and Immunopathology, 119(1-2), 63–80.
author keywords: horse; immunology; leukocyte differentiation
MeSH headings : Animals; Antibodies, Monoclonal / immunology; Antigens, CD / immunology; Cross Reactions; Flow Cytometry; Horses / immunology; Humans; Leukocytes / immunology; Rats
TL;DR:
The results underline the value of this "cross-reactivity" approach for equine immunology, as only a few mAbs against leukocyte surface antigens reacted positively (approximately 4% of the mAbs submitted), and the analysis of further anti-human mAbs and directed efforts to develop species-specific anti-CD mAb are still required.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2006 journal article
Antibody and cellular immune responses following DNA vaccination and EHV-1 infection of ponies
Veterinary Immunology and Immunopathology, 111(1-2), 81–95.
author keywords: EHV-1; horses; DNA vaccination; CTL
MeSH headings : Animals; Antibodies, Viral / blood; Cell Proliferation; Female; Genes, Immediate-Early / genetics; Genes, Immediate-Early / immunology; Herpesviridae Infections / immunology; Herpesviridae Infections / prevention & control; Herpesviridae Infections / veterinary; Herpesviridae Infections / virology; Herpesvirus 1, Equid / immunology; Herpesvirus Vaccines / immunology; Herpesvirus Vaccines / therapeutic use; Horse Diseases / immunology; Horse Diseases / prevention & control; Horse Diseases / virology; Horses; Immunoglobulin Idiotypes / immunology; Male; Neutralization Tests / veterinary; T-Lymphocytes, Cytotoxic / immunology; T-Lymphocytes, Cytotoxic / virology; Vaccination / methods; Vaccination / veterinary; Vaccines, DNA / immunology; Vaccines, DNA / therapeutic use; Viral Envelope Proteins / genetics; Viral Envelope Proteins / immunology; Virus Latency / immunology
TL;DR:
In summary, particle-mediated EHV-1 DNA vaccination induced limited immune responses and protection, and future vaccination strategies must focus on generating stronger CTL responses.
(via Semantic Scholar)
Source: Crossref
Added: July 27, 2019
2006 journal article
Cytokine responses to EHV-1 infection in immune and non-immune ponies
Veterinary Immunology and Immunopathology, 111(1-2), 109–116.
author keywords: horses; equine herpesvirus-1; IFN-gamma; IL-4
MeSH headings : Animals; Antibodies, Viral / blood; Cell Proliferation; DNA / chemistry; DNA / genetics; Herpesviridae Infections / genetics; Herpesviridae Infections / immunology; Herpesviridae Infections / veterinary; Herpesviridae Infections / virology; Herpesvirus 1, Equid / genetics; Herpesvirus 1, Equid / immunology; Horse Diseases / genetics; Horse Diseases / immunology; Horse Diseases / virology; Horses; Interferon-gamma / biosynthesis; Interferon-gamma / genetics; Interferon-gamma / immunology; Interleukin-4 / biosynthesis; Interleukin-4 / genetics; Interleukin-4 / immunology; Leukocytes, Mononuclear / cytology; Leukocytes, Mononuclear / virology; Male; Nasal Mucosa / virology; Neutralization Tests / veterinary; Polymerase Chain Reaction / veterinary; RNA, Messenger / biosynthesis; RNA, Messenger / genetics
TL;DR:
Protective immunity to EHV-1 infection was characterized by a polarized IFN-gamma dependent immunoregulatory cytokine response.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2006 journal article
Detection and Quantification of Equine Herpesvirus-1 Viremia and Nasal Shedding by Real-Time Polymerase Chain Reaction
Journal of Veterinary Diagnostic Investigation, 18(4), 335–342.
author keywords: diagnosis; equine herpesvirus-1; real-time PCR
MeSH headings : Animals; Female; Herpesvirus 1, Equid / genetics; Herpesvirus 1, Equid / isolation & purification; Horse Diseases / diagnosis; Horse Diseases / virology; Horses / virology; Male; Polymerase Chain Reaction / methods; Polymerase Chain Reaction / veterinary; Sensitivity and Specificity; Viremia / veterinary; Viremia / virology; Virus Latency; Virus Shedding
TL;DR:
It is concluded that real-time PCR is a sensitive and quantitative test for EHV-1 nasal shedding and viremia and provides a valuable tool for E hvirus-1 surveillance, diagnosis of clinical disease, and investigation of vaccine efficacy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: July 27, 2019
2006 journal article
EHV-1 special edition
Veterinary Immunology and Immunopathology, 111(1-2), 1.
MeSH headings : Animals; Herpesviridae Infections / immunology; Herpesviridae Infections / prevention & control; Herpesviridae Infections / veterinary; Herpesviridae Infections / virology; Herpesvirus 1, Equid; Horse Diseases / immunology; Horse Diseases / prevention & control; Horse Diseases / virology; Horses
Source: Crossref
Added: August 28, 2020
2006 journal article
Foals are interferon gamma-deficient at birth
Veterinary Immunology and Immunopathology, 112(3-4), 199–209.
author keywords: equine; real time PCR; BAL; IFN; cytokine; flow cytometry; neonate
MeSH headings : Age Factors; Animals; Animals, Newborn; Bronchoalveolar Lavage Fluid / cytology; Bronchoalveolar Lavage Fluid / immunology; Colostrum / immunology; Flow Cytometry / veterinary; Gene Expression Regulation; Horses / genetics; Horses / immunology; Immunity, Innate / immunology; Interferon-gamma / deficiency; Interferon-gamma / genetics; Interferon-gamma / immunology; Ionomycin / pharmacology; Leukocytes, Mononuclear / drug effects; Leukocytes, Mononuclear / immunology; Lymphocyte Activation; Lymphocytes / immunology; RNA, Messenger / biosynthesis; RNA, Messenger / genetics; Random Allocation; Reverse Transcriptase Polymerase Chain Reaction / veterinary; Tetradecanoylphorbol Acetate / pharmacology
TL;DR:
It is suggested that foals are born with an inherent inability to mount a Th1-based cell mediated immune response which may contribute to their susceptibility to intracellular pathogens.
(via Semantic Scholar)
Source: Crossref
Added: July 27, 2019
2006 journal article
Immune responses to commercial equine vaccines against equine herpesvirus-1, equine influenza virus, eastern equine encephalomyelitis, and tetanus
Veterinary Immunology and Immunopathology, 111(1-2), 67–80.
author keywords: horses; vaccination; infectious disease
MeSH headings : Animals; Antibodies, Viral / blood; Clostridium tetani / immunology; DNA, Viral / chemistry; DNA, Viral / genetics; Encephalitis Virus, Eastern Equine / immunology; Encephalomyelitis, Equine / immunology; Encephalomyelitis, Equine / prevention & control; Encephalomyelitis, Equine / veterinary; Encephalomyelitis, Equine / virology; Female; Herpesviridae Infections / immunology; Herpesviridae Infections / prevention & control; Herpesviridae Infections / veterinary; Herpesviridae Infections / virology; Herpesvirus 1, Equid / genetics; Herpesvirus 1, Equid / immunology; Horse Diseases / immunology; Horse Diseases / prevention & control; Horse Diseases / virology; Horses; Immunoassay / veterinary; Influenza A Virus, H3N8 Subtype / immunology; Interferon-gamma / blood; Neutralization Tests / veterinary; Orthomyxoviridae Infections / immunology; Orthomyxoviridae Infections / prevention & control; Orthomyxoviridae Infections / veterinary; Orthomyxoviridae Infections / virology; Polymerase Chain Reaction; Tetanus / immunology; Tetanus / prevention & control; Tetanus / veterinary; Tetanus / virology; Viral Vaccines / immunology; Viral Vaccines / therapeutic use
TL;DR:
Overall there were wide variations in vaccine response, and the vaccines with the best responses were not produced by a single manufacturer; differences in vaccine performance may have resulted from differences in antigen load and adjuvant formulation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2006 chapter
Immunology and Immunopathology
In B. McGorum, E. Robinson, P. Dixon, & J. Schumacher (Eds.), Equine Respiratory Disorders (1st ed., pp. 71–82). Philadelphia: Elsevier.
Ed(s): B. McGorum, E. Robinson, P. Dixon & J. Schumacher
Source: NC State University Libraries
Added: August 4, 2019
2006 journal article
Report of the equine herpesvirus-1 Havermeyer Workshop, San Gimignano, Tuscany, June 2004
Veterinary Immunology and Immunopathology, 111(1-2), 3–13.
author keywords: horses; equine herpesvirus-1
MeSH headings : Animals; Herpesviridae Infections / immunology; Herpesviridae Infections / prevention & control; Herpesviridae Infections / veterinary; Herpesviridae Infections / virology; Herpesvirus 1, Equid; Horse Diseases / immunology; Horse Diseases / prevention & control; Horse Diseases / virology; Horses
TL;DR:
This report highlights the new information that was the focus of a workshop convened in San Gimignano, Tuscany, Italy in June 2004, and is intended to summarize this material and identify the critical questions in the field.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2005 journal article
Immunization with recombinant modified vaccinia Ankara (rMVA) constructs encoding the HA or NP gene protects ponies from equine influenza virus challenge
Vaccine, 24(8), 1180–1190.
author keywords: horses; influenza virus; vaccination; haemaggluttinin; nucleoprotein
MeSH headings : Animals; Antibodies, Viral / blood; Hemagglutinin Glycoproteins, Influenza Virus / genetics; Hemagglutinin Glycoproteins, Influenza Virus / immunology; Horse Diseases / prevention & control; Horses; Immunoglobulin G / blood; Influenza A Virus, H3N8 Subtype / immunology; Influenza Vaccines / immunology; Interferon-gamma / genetics; Nucleocapsid Proteins / genetics; Nucleocapsid Proteins / immunology; Orthomyxoviridae Infections / prevention & control; Orthomyxoviridae Infections / veterinary; RNA, Messenger / analysis; T-Lymphocytes, Cytotoxic / immunology; Vaccination / veterinary; Vaccines, Synthetic / immunology; Vaccinia virus / genetics; Vaccinia virus / immunology; Virus Shedding
TL;DR:
It is demonstrated that vaccination of horses with rMVA alone, or as part of a prime-boost regimen, is an effective means of inducing protective immunity to influenza virus infection, and also indicates that NP-specific immune responses can contribute to protection of horses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2005 journal article
Leukocyte emigration in the early stages of laminitis
Veterinary Immunology and Immunopathology, 109(1-2), 161–166.
author keywords: laminitis; neutrophil; leukocyte emigration; CD13; sepsis
MeSH headings : Animals; CD13 Antigens / immunology; Cell Movement / immunology; Disease Models, Animal; Foot Diseases / immunology; Foot Diseases / veterinary; Horse Diseases / immunology; Horses; Immunohistochemistry / veterinary; Leukocyte Count / veterinary; Leukocytes, Mononuclear / immunology; Skin Diseases / immunology; Skin Diseases / veterinary
TL;DR:
Findings indicate that, similar to organ failure in human sepsis, leukocyte emigration is likely to play a significant role in initiating numerous pathophysiologic mechanisms that lead to the development of laminitis.
(via Semantic Scholar)
Source: Crossref
Added: July 27, 2019
2004 journal article
Equine herpesvirus-1 infection induces IFN-γ production by equine T lymphocyte subsets
Veterinary Immunology and Immunopathology, 103(3-4), 207–215.
author keywords: horses; EHV-1; intracellular staining; flow cytometry; interferon gamma
MeSH headings : Animals; Antibodies, Monoclonal / immunology; Flow Cytometry / veterinary; Herpesviridae Infections / immunology; Herpesviridae Infections / veterinary; Herpesviridae Infections / virology; Herpesvirus 1, Equid / immunology; Horse Diseases / immunology; Horse Diseases / virology; Horses; Interferon-gamma / biosynthesis; Interferon-gamma / immunology; Ionomycin / immunology; Lymphocyte Activation / immunology; Retrospective Studies; T-Lymphocyte Subsets / immunology; T-Lymphocyte Subsets / virology; T-Lymphocytes, Cytotoxic / immunology; Tetradecanoylphorbol Acetate / immunology
TL;DR:
It is demonstrated that EHV-1 challenge infection of ponies results in increased production of IFN-γ by virus-specific T lymphocytes, and that this response can be quantitated using flow cytometry.
(via Semantic Scholar)
Source: Crossref
Added: July 27, 2019
2004 journal article
Use of recombinant modified vaccinia Ankara viral vectors for equine influenza vaccination
Veterinary Immunology and Immunopathology, 98(3-4), 127–136.
author keywords: horses; influenza virus; vaccination; modified vaccinia Ankara
MeSH headings : Animals; Antibodies, Viral / blood; Base Sequence; Enzyme-Linked Immunosorbent Assay / veterinary; Genetic Vectors / genetics; Genetic Vectors / immunology; Horse Diseases / immunology; Horse Diseases / prevention & control; Horse Diseases / virology; Horses; Influenza A virus / genetics; Influenza A virus / immunology; Interferon-gamma / chemistry; Interferon-gamma / genetics; Male; Molecular Sequence Data; Orthomyxoviridae Infections / immunology; Orthomyxoviridae Infections / prevention & control; Orthomyxoviridae Infections / veterinary; Orthomyxoviridae Infections / virology; RNA, Messenger / chemistry; RNA, Messenger / genetics; Reassortant Viruses / immunology; Reverse Transcriptase Polymerase Chain Reaction / veterinary; Sequence Analysis, DNA; Vaccination / methods; Vaccination / veterinary; Vaccines, DNA / genetics; Vaccines, DNA / immunology; Vaccines, DNA / therapeutic use; Vaccinia virus / genetics; Viral Vaccines / genetics; Viral Vaccines / immunology; Viral Vaccines / therapeutic use
TL;DR:
This study demonstrates the facility with which recombinant MVA viruses expressing defined pathogen genes can be constructed, and provides preliminary evidence of the immunogenicity and safety of these vectors in the horse.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2003 journal article
Advances in equine immunology: Havemeyer workshop reports from Santa Fe, New Mexico, and Hortobagy, Hungary
Veterinary Immunology and Immunopathology, 91(3-4), 233–243.
MeSH headings : Animals; Bites and Stings / complications; Bites and Stings / immunology; Bites and Stings / veterinary; Communicable Diseases / immunology; Communicable Diseases / veterinary; Horse Diseases / immunology; Horses / genetics; Horses / immunology; Hypersensitivity / complications; Hypersensitivity / immunology; Hypersensitivity / veterinary; Immunity, Mucosal; Immunogenetics; Inflammation / immunology; Inflammation / veterinary; Insecta
TL;DR:
This report summarizes the scientific themes and foci of two major equine immunology workshops held in 2001, with a focus on control of many common infectious diseases and immunopathologic conditions of broad comparative interest.
(via Semantic Scholar)
Source: Crossref
Added: July 27, 2019
2003 journal article
Equine platelet CD62P (P-selectin) expression: a phenotypic and morphologic study
Veterinary Immunology and Immunopathology, 91(2), 119–134.
author keywords: flow cytometric analysis; equine platelet CD62P (P-selectin) and CD41/61; leukocyte CD11a/CD18; platelet-leukocyte aggregates
MeSH headings : Animals; Antibody Specificity; Blood Platelets / drug effects; Blood Platelets / metabolism; Flow Cytometry; Gene Expression; Horses / blood; Humans; Leukocytes / metabolism; P-Selectin / analysis; Platelet Aggregation; Thrombin / pharmacology; Time Factors
TL;DR:
The research illustrates that in healthy horses, P-selectin is also constitutively expressed on 20-25% of resting platelets, in direct contrast to humans, in which P- selectin expression is negligible in the absence of agonist activation.
(via Semantic Scholar)
Source: Crossref
Added: July 27, 2019
2003 journal article
Identification of equine herpesvirus-1 antigens recognized by cytotoxic T lymphocytes
Journal of General Virology, 84(10), 2625–2634.
MeSH headings : Animals; Antigens, Viral / genetics; Antigens, Viral / immunology; Cells, Cultured; Dendritic Cells / immunology; Dendritic Cells / virology; Herpesviridae Infections / immunology; Herpesviridae Infections / veterinary; Herpesviridae Infections / virology; Herpesvirus 1, Equid / genetics; Herpesvirus 1, Equid / immunology; Horse Diseases / immunology; Horse Diseases / virology; Horses; Lymphocyte Activation; T-Lymphocytes, Cytotoxic / immunology; Transfection; Viral Proteins / genetics; Viral Proteins / immunology
TL;DR:
This is the first identification of an EHV-1 protein containing ELA-A-restricted CTL epitopes, and this assay can now be used to study CTL specificity for EHv-1 proteins in horses with a broad range of E LA-A haplotypes, with the goal of developing a multi-epitope EH V-1 vaccine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 4, 2019
2003 journal article
Mucosal co-administration of cholera toxin and influenza virus hemagglutinin-DNA in ponies generates a local IgA response
Vaccine, 21(21-22), 3081–3092.
author keywords: equine influenza virus; DNA vaccination; cholera toxin
MeSH headings : Administration, Intranasal; Animals; Antibodies, Viral / blood; Cholera Toxin / administration & dosage; Cholera Toxin / immunology; Female; Hemagglutinins, Viral / genetics; Horse Diseases / immunology; Horse Diseases / prevention & control; Horse Diseases / virology; Horses; Immunity, Mucosal; Immunoglobulin A / biosynthesis; Influenza A virus; Influenza Vaccines / administration & dosage; Influenza Vaccines / immunology; Male; Nasal Mucosa / immunology; Orthomyxoviridae Infections / immunology; Orthomyxoviridae Infections / prevention & control; Orthomyxoviridae Infections / veterinary; Vaccination / veterinary; Vaccines, DNA / administration & dosage; Vaccines, DNA / immunology
TL;DR:
The objective of this study was to examine the value of cholera toxin administration as an adjuvant for intranasal HA DNA vaccination, and to measure protection 3 months after DNA vaccination.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2003 journal article
Onset of immunoglobulin production in foals
Equine Veterinary Journal, 35(6), 620–622.
author keywords: horse; foal; IgG subclass; antibody; maternal antibody
MeSH headings : Animals; Animals, Newborn / blood; Animals, Newborn / immunology; Colostrum / immunology; Horses / blood; Horses / immunology; Immunity, Maternally-Acquired; Immunoglobulin A / biosynthesis; Immunoglobulin A / blood; Immunoglobulin G / biosynthesis; Immunoglobulin G / blood; Immunoglobulins / biosynthesis; Immunoglobulins / blood
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2003 journal article
Regional antibody and cellular immune responses to equine influenza virus infection, and particle mediated DNA vaccination
Veterinary Immunology and Immunopathology, 94(1-2), 47–62.
author keywords: infectious immunity virus; viral immunology; vaccination
MeSH headings : Animals; Antibodies, Viral / immunology; Antibody Specificity; Cytokines / genetics; Cytokines / immunology; Female; Hemagglutinin Glycoproteins, Influenza Virus / immunology; Horse Diseases / immunology; Horse Diseases / virology; Horses / immunology; Horses / virology; Influenza A virus / immunology; Influenza Vaccines / immunology; Lymph Nodes / cytology; Lymph Nodes / immunology; Male; Orthomyxoviridae Infections / immunology; Orthomyxoviridae Infections / prevention & control; Orthomyxoviridae Infections / veterinary; Vaccines, DNA / immunology; Virus Shedding
TL;DR:
Common features of immune responses to either influenza virus infection or DNA vaccination were virus-specific IgGa, IgGb and IFN-gamma responses, which are associated with protection from infection, even when the regional distribution of these immune responses varied depending on the site of immune encounter.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2001 journal article
A new modified live equine influenza virus vaccine: phenotypic stability, restricted spread and efficacy against heterologous virus challenge
Equine Veterinary Journal, 33(7), 630–636.
author keywords: horse; intranasal; antigenic drift; backpassage; challenge; cold-adapted; modified-live virus
MeSH headings : Administration, Intranasal; Animals; Female; Horse Diseases / prevention & control; Horse Diseases / transmission; Horses; Influenza A virus / immunology; Influenza Vaccines / administration & dosage; Influenza Vaccines / immunology; Influenza Vaccines / standards; Male; Nebulizers and Vaporizers / veterinary; Orthomyxoviridae Infections / prevention & control; Orthomyxoviridae Infections / transmission; Orthomyxoviridae Infections / veterinary; Phenotype; Safety; Serial Passage; Time Factors; Treatment Outcome; Vaccination / veterinary; Vaccines, Attenuated / administration & dosage; Vaccines, Attenuated / immunology; Vaccines, Attenuated / standards; Virus Shedding
TL;DR:
Results demonstrate that Flu Avert IN vaccine is safe and phenotypically stable, has low spontaneous transmissibility and is effective in protecting horses against challenge viruses representative of those in circulation worldwide.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2001 journal article
Evaluation of IgG concentration and IgG subisotypes in foals with complete or partial failure of passive transfer after administration of intravenous serum or plasma
Equine Veterinary Journal, 33(7), 681–686.
author keywords: horse; foal; failure of passive transfer; transfusion; IgG subisotype; plasma; serum
MeSH headings : Animals; Animals, Newborn / blood; Animals, Newborn / immunology; Horse Diseases / immunology; Horses / blood; Horses / immunology; Immunity, Maternally-Acquired / immunology; Immunization, Passive / methods; Immunization, Passive / veterinary; Immunoglobulin G / administration & dosage; Immunoglobulin G / blood; Immunoglobulin Isotypes / administration & dosage; Immunoglobulin Isotypes / blood; Influenza Vaccines / administration & dosage; Injections, Intravenous / veterinary; Orthomyxoviridae Infections / immunology; Orthomyxoviridae Infections / veterinary; Tetanus / immunology; Tetanus / veterinary; Tetanus Toxoid / administration & dosage
TL;DR:
The results of this study suggest that similar foal serum IgG concentrations can be achieved 3 days post-transfusion by administering 1 unit of plasma or 2-3 units of serum product.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 4, 2019
2001 journal article
Immunophenotypic Classification of Leukemia in 3 Horses
Journal of Veterinary Internal Medicine, 15(2), 144–152.
Source: Crossref
Added: July 27, 2019
2001 journal article
Passive transfer of maternal immunoglobulin isotype antibodies against tetanus and influenza and their effect on the response of foals to vaccination
Equine Veterinary Journal, 33(7), 644–650.
author keywords: horse; foals; vaccination; maternal antibodies; immunoglobulin; influenza; tetanus
MeSH headings : Adjuvants, Immunologic / administration & dosage; Animals; Animals, Newborn / immunology; Animals, Suckling / immunology; Antibodies, Bacterial / blood; Antibodies, Viral / blood; Colostrum / immunology; Female; Horse Diseases / immunology; Horse Diseases / microbiology; Horse Diseases / virology; Horses; Immunity, Maternally-Acquired; Immunoglobulin G / analysis; Immunoglobulin G / blood; Influenza Vaccines / administration & dosage; Influenza Vaccines / immunology; Orthomyxoviridae Infections / immunology; Orthomyxoviridae Infections / veterinary; Pregnancy; Tetanus / immunology; Tetanus / veterinary; Tetanus Toxoid / administration & dosage; Tetanus Toxoid / immunology; Time Factors; Vaccination / methods; Vaccination / veterinary; Vaccines, Inactivated / administration & dosage; Vaccines, Inactivated / immunology
TL;DR:
Based on the finding that maternal antibodies exert a significant inhibitory effect on the response of foals to tetanus toxoid and inactivated influenza antigens, it is recommended that primary immunisation of foal born to vaccinated mares should not commence before age 6 months.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2001 journal article
Pharyngeal lymphoid tissue: gatekeeper or showstopper?
Equine Veterinary Journal, 33(3), 218–220.
MeSH headings : Animals; Horses / immunology; Immunity, Mucosal; Lymphoid Tissue / physiology; Palatine Tonsil / immunology; Palatine Tonsil / physiology; Respiratory Mucosa / physiology
Source: Crossref
Added: July 27, 2019
2001 journal article
Safety, efficacy, and immunogenicity of a modified-live equine influenza virus vaccine in ponies after induction of exercise-induced immunosuppression
Journal of the American Veterinary Medical Association, 218(6), 900–906.
MeSH headings : Administration, Intranasal; Animals; Antibodies, Viral / biosynthesis; Hemagglutination Inhibition Tests / veterinary; Horse Diseases / immunology; Horse Diseases / prevention & control; Horses; Immune Tolerance / immunology; Immunoglobulin A / biosynthesis; Immunoglobulin G / biosynthesis; Immunosuppression Therapy / veterinary; Influenza A virus / immunology; Influenza Vaccines / immunology; Influenza Vaccines / standards; Lymphocyte Activation / immunology; Nebulizers and Vaporizers / veterinary; Orthomyxoviridae Infections / immunology; Orthomyxoviridae Infections / prevention & control; Orthomyxoviridae Infections / veterinary; Physical Exertion / physiology; Prospective Studies; Safety; Time Factors; Treatment Outcome; Vaccination / veterinary; Vaccines, Attenuated / immunology; Vaccines, Attenuated / standards; Virus Shedding
TL;DR:
Administration of this MLV vaccine to ponies with exercise-induced immunosuppression was safe and that administration of a single dose to ponies provided clinical protection 3 months later.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2000 journal article
Effects of dexamethasone on development of immunoglobulin G subclass responses following vaccination of horses
American Journal of Veterinary Research, 61(12), 1530–1533.
MeSH headings : Animals; Antibodies, Viral / blood; Antibody Formation / drug effects; Dexamethasone / pharmacology; Female; Horses; Immunoglobulin G / blood; Immunoglobulin G / classification; Male; Skin Tests; Time Factors; Vaccines, Inactivated; Viral Vaccines
TL;DR:
Corticosteroid treatment regimens commonly used to treat diseases in horses may result induction of a nonprotective IgG subclass response, leaving treated horses susceptible to disease and further defining these mechanisms is a critical step in designing effective vaccines.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2000 journal article
Equine Vaccination
Journal of Veterinary Internal Medicine, 14(2), 221–222.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2000 journal article
Equine Vaccination
Veterinary Clinics of North America: Equine Practice, 16(1), 199–226.
MeSH headings : Animals; Horse Diseases / prevention & control; Horses; Vaccination / veterinary
TL;DR:
An improved knowledge of the immunologic basis of successful vaccination, combined with the appropriate integration of effective vaccines into well-designed disease control policies, is needed to resolve concerns about the efficacy of some equine vaccination strategies.
(via Semantic Scholar)
Source: Crossref
Added: July 27, 2019
2000 journal article
Immunodiagnostic Testing in Horses
Veterinary Clinics of North America: Equine Practice, 16(1), 79–103.
MeSH headings : Animals; Antibody Formation; Flow Cytometry / veterinary; Horse Diseases / diagnosis; Horses; Immunity, Cellular; Immunologic Tests / methods; Immunologic Tests / veterinary; Lymphocytes / physiology; Polymerase Chain Reaction / veterinary
TL;DR:
If applied rationally, with an understanding of the questions the tests answer as well as the limitations that constrain their use, these tests can serve as valuable aids in the diagnosis and management of equine diseases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2000 book
Immunology
In Veterinary Clinics of North America: Equine Practice (Vol. 16).
Ed(s): A. Turner, D. Lunn & D. Horohov
Source: NC State University Libraries
Added: August 4, 2019
2000 journal article
Molecular cloning, sequencing, and expression of equine interleukin-6
Veterinary Immunology and Immunopathology, 77(3-4), 213–220.
author keywords: Equine interleukin-6 (IL-6) cloning expression
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; CHO Cells; Cloning, Molecular; Cricetinae; Horses / immunology; Interleukin-6 / biosynthesis; Interleukin-6 / chemistry; Interleukin-6 / genetics; Molecular Sequence Data; Recombinant Proteins / biosynthesis
TL;DR:
Equine interleukin-6 (IL-6) cDNA was amplified from mitogen-stimulated equine peripheral blood mononuclear cells (PBMC) using consensus sequence primers and yielded a supernatant that supported the proliferation of B9 cells in a dose-dependent manner.
(via Semantic Scholar)
Source: Crossref
Added: July 27, 2019
2000 journal article
Placental expression of the nonclassical MHC class I molecule Mamu-AG at implantation in the rhesus monkey
Proceedings of the National Academy of Sciences, 97(16), 9104–9109.
MeSH headings : Animals; Antibodies, Monoclonal / immunology; Embryo Implantation / immunology; Female; Histocompatibility Antigens Class I / genetics; Histocompatibility Antigens Class I / immunology; Immunohistochemistry; Macaca mulatta; Placenta / immunology; Pregnancy; RNA, Messenger / genetics; RNA, Messenger / metabolism
TL;DR:
The ontogeny of a nonclassical MHC class I molecule at the implantation site supports the hypothesis that its expression is important for the establishment of maternal-fetal immune tolerance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
1999 journal article
Antibody responses to DNA vaccination of horses using the influenza virus hemagglutinin gene
Vaccine, 17(18), 2245–2258.
author keywords: infectious immunity-virus; veterinary immunology; vaccination
MeSH headings : Animals; Antibodies, Viral / biosynthesis; Female; Hemagglutinin Glycoproteins, Influenza Virus / genetics; Hemagglutinin Glycoproteins, Influenza Virus / immunology; Horse Diseases / immunology; Horse Diseases / virology; Horses; Influenza A virus / chemistry; Influenza A virus / immunology; Influenza A virus / isolation & purification; Influenza Vaccines / genetics; Influenza Vaccines / immunology; Male; Orthomyxoviridae Infections / immunology; Orthomyxoviridae Infections / prevention & control; Orthomyxoviridae Infections / veterinary; Vaccines, DNA / immunology
TL;DR:
It is demonstrated that HA-DNA vaccination induces IgG (a) and IgG(b) antibody responses which are associated with protection in the absence of mucosal IgA responses, which occurred with a higher frequency in the skin and mucosa vaccinated ponies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
1999 chapter
Development of practical DNA vaccination strategies for use in horses
In U. Wernery, J. A. Wade, J. A. Mumford, & O.-R. Kaaden (Eds.), Equine Infectious Diseases VIII (pp. 38–43). Newmarket: R&W Publications.
Ed(s): U. Wernery, J. Wade, J. Mumford & O. Kaaden
Source: NC State University Libraries
Added: August 4, 2019
1999 journal article
Effects of Experimentally Generated Bull Antisperm Antibodies on In Vitro Fertilization1
Biology of Reproduction, 60(6), 1285–1291.
MeSH headings : Animals; Autoantibodies / pharmacology; Autoantigens / immunology; Cattle / immunology; Cattle Diseases / immunology; Enzyme-Linked Immunosorbent Assay; Fertilization in Vitro; Immunization; Immunoglobulin G / biosynthesis; Immunoglobulin G / immunology; Infertility, Male / immunology; Infertility, Male / veterinary; Male; Spermatozoa / immunology
TL;DR:
It is demonstrated that antisperm IgG1 and IgG2 generated by sperm auto-immunizations reduced fertility in vitro, and therefore naturally occurring antisperm antibodies may affect fertility in bulls.
(via Semantic Scholar)
Source: Crossref
Added: July 27, 2019
1999 chapter
Immunological principles of equine vaccination
In J. Moore & I. Mayhew (Eds.), Equine Medicine and Surgery (5th ed., pp. 183–190). Mosby, Inc.
Ed(s): J. Moore & I. Mayhew
Source: NC State University Libraries
Added: August 4, 2019
1999 chapter
Practical applications of equine vaccination
In J. Moore & I. Mayhew (Eds.), Equine Medicine and Surgery (5th ed., pp. 191–195). Mosby Inc.
Ed(s): J. Moore & I. Mayhew
Source: NC State University Libraries
Added: August 4, 2019
1998 journal article
Antibody selection for immunohistochemical survey of equine tissue
Journal of Comparative Pathology, 119(4), 467–472.
MeSH headings : Acetic Acid / immunology; Animals; Antibodies, Monoclonal / metabolism; Antibody Specificity / immunology; B-Lymphocytes / immunology; Ethanol / immunology; Formaldehyde / immunology; Histocompatibility Antigens Class II / immunology; Horses / immunology; Humans; Immunohistochemistry; Lymph Nodes / immunology; Palatine Tonsil / immunology; Picrates / immunology; T-Lymphocytes / immunology; Tissue Fixation
TL;DR:
The anti-equine and anti-human monoclonal antibodies specific for MHC Class II antigens, T and B lymphocytes, and macrophages expanded the desired range of reactivity and increased the consistency in different animals.
(via Semantic Scholar)
Source: Crossref
Added: July 27, 2019
1998 journal article
Co-administration of DNA encoding interleukin-6 and hemagglutinin confers protection from influenza virus challenge in mice
Journal of Virology, 72, 1704–1708.
Source: NC State University Libraries
Added: August 4, 2019
1998 journal article
Denaturing gradient gel electrophoresis: a rapid method for differentiating BoLA-DRB3 alleles
Animal Genetics, 29(5), 389–394.
author keywords: BoLA-DRB3; bovine lymphocyte antigen; denaturing gradient gel electrophoresis; major histocompatibility complex
MeSH headings : Alleles; Animals; Base Sequence; Cattle / genetics; Cattle / immunology; DNA / genetics; DNA / isolation & purification; DNA Primers / genetics; Electrophoresis, Polyacrylamide Gel / methods; Genes, MHC Class II; Histocompatibility Testing / methods; Histocompatibility Testing / veterinary; Nucleic Acid Denaturation; Polymerase Chain Reaction
TL;DR:
Denaturing gradient gel electrophoresis (DGGE) is reliable and rapid, and avoids cloning alleles prior to nucleotide sequencing and therefore offers distinct advantages over previous techniques for BoLA-DRB3-typing.
(via Semantic Scholar)
Source: Crossref
Added: July 27, 2019
1998 journal article
Effect of colostral ingestion on immunoglobulin-positive cells in calves
Veterinary Immunology and Immunopathology, 62(1), 51–64.
author keywords: calves; immunity; colostrum; B-cells; immunohistochemistry; immunomodulation
MeSH headings : Animals; Animals, Newborn / immunology; B-Lymphocytes / immunology; CD4 Lymphocyte Count; Cattle / immunology; Colostrum / immunology; Female; Immune System; Immunoenzyme Techniques / veterinary; Immunoglobulin A / analysis; Immunoglobulin G / analysis; Immunoglobulin M / analysis; Lymph Nodes / cytology; Pregnancy
TL;DR:
It is demonstrated that colostrum feeding reduces the number of immunoglobulin positive cells in the lymphoid tissues of newborn calves in an isotype-specific manner, resulting in the elimination of IgG1 and IgG2 positive cells that are present in both fetuses and newborn calves.
(via Semantic Scholar)
Source: Crossref
Added: July 27, 2019
1998 chapter
Immunology of Horses and Donkeys
In P.-P. Pastoret, H. Bazin, P. Griebel, & A. Govaerts (Eds.), Handbook of Vertebrate Immunology (pp. 343–371).
Ed(s): P. Pastoret, H. Bazin, P. Griebel & A. Govaerts
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Crossref
Added: August 4, 2019
1998 journal article
Local and systemic isotype-specific antibody responses to equine influenza virus infection versus conventional vaccination
Vaccine, 16(13), 1306–1313.
author keywords: horses; influenza virus; mucosal immunity
MeSH headings : Animals; Antibodies, Viral / biosynthesis; Horse Diseases / immunology; Horse Diseases / prevention & control; Horses; Immunity, Mucosal; Immunoglobulin A / biosynthesis; Immunoglobulin A, Secretory / biosynthesis; Immunoglobulin G / biosynthesis; Influenza A virus / immunology; Influenza Vaccines / immunology; Nasal Mucosa / immunology; Orthomyxoviridae Infections / immunology; Orthomyxoviridae Infections / prevention & control; Orthomyxoviridae Infections / veterinary; Recurrence; Vaccination / veterinary; Virus Shedding / immunology
TL;DR:
It is demonstrated that the protective immunity generated by natural equine influenza virus infection is associated with a mucosal IgA immune response and humoral IgGa and IgGb sub-isotype responses, and that this pattern of response is not generated by conventional vaccines.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 4, 2019
1998 journal article
Monoclonal antibodies to subclass-specific antigenic determinants on equine immunoglobulin gamma chains and their characterization
Veterinary Immunology and Immunopathology, 62(2), 153–165.
author keywords: horses; immunglobulins; antigens
MeSH headings : Animals; Antibodies, Monoclonal / immunology; Chromatography, Affinity; Enzyme-Linked Immunosorbent Assay; Epitopes / immunology; Female; Horses / immunology; Immunoblotting; Immunoglobulin G / immunology; Immunoglobulin gamma-Chains / immunology; Mice; Mice, Inbred BALB C / immunology
TL;DR:
A panel of monoclonal antibodies was produced identifying the four recognised equine IgG subisotypes IgG, IgGa, IgGb, IgGc and IgG(T) using a combination of gel filtration, salt precipitation, ion exchange chromatography and protein A and Protein G affinity chromatography.
(via Semantic Scholar)
Source: Crossref
Added: July 27, 2019
1998 journal article
Report of the Second Equine Leucocyte Antigen Workshop, Squaw Valley, California, July 1995
Veterinary Immunology and Immunopathology, 62(2), 101–143.
author keywords: equine; leucocyte antigen; CD; immunoglobulin; monoclonal antibody
MeSH headings : Animals; Histocompatibility Antigens / classification; Histocompatibility Antigens / immunology; Horses / immunology; Immunoglobulins / classification; Immunoglobulins / immunology; Immunologic Techniques
TL;DR:
The Second Equine Leucocyte Antigen Workshop made considerable advances in pursuing the objectives of establishing the specificities of mAbs and achieving consensus on the nomenclature for equine leucocyte and immunoglobulin molecules.
(via Semantic Scholar)
Source: Crossref
Added: July 27, 2019
1997 journal article
Equine chorionic girdle cells: molecular aspects
ARTA, 9, 223–235.
Source: NC State University Libraries
Added: August 4, 2019
1997 journal article
Immunogenicity and efficacy of baculovirus-expressed and DNA-based equine influenza virus hemagglutinin vaccines in mice
Vaccine, 15(10), 1149–1156.
author keywords: influenza virus; recombinant baculovirus; DNA vaccination
MeSH headings : Adjuvants, Immunologic / administration & dosage; Animals; Antibodies, Viral / blood; Baculoviridae / genetics; Base Sequence; Cholera Toxin / administration & dosage; DNA Primers / genetics; Hemagglutinins, Viral / genetics; Hemagglutinins, Viral / immunology; Immunization Schedule; Immunization, Secondary; Influenza A virus / genetics; Influenza A virus / immunology; Influenza A virus / isolation & purification; Influenza Vaccines / administration & dosage; Influenza Vaccines / genetics; Influenza Vaccines / pharmacology; Lung / virology; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Orthomyxoviridae Infections / immunology; Orthomyxoviridae Infections / prevention & control; Orthomyxoviridae Infections / virology; Polymerase Chain Reaction; Vaccines, DNA / administration & dosage; Vaccines, DNA / genetics; Vaccines, DNA / pharmacology
TL;DR:
Results indicate that the time between initial and booster DNA vaccinations may be an important variable in determining DNA vaccination efficacy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
1997 journal article
Nosocomial Transmission of Cryptosporidium in a Veterinary Hospital
Journal of Veterinary Internal Medicine, 11(6), 340–343.
MeSH headings : Animals; Animals, Newborn; Cattle; Cattle Diseases; Cross Infection / transmission; Cross Infection / veterinary; Cryptosporidiosis / therapy; Cryptosporidiosis / transmission; Cryptosporidiosis / veterinary; Cryptosporidium / isolation & purification; Cryptosporidium parvum / isolation & purification; Diarrhea / microbiology; Diarrhea / veterinary; Euthanasia; Feces / microbiology; Female; Horse Diseases; Horses; Hospital Design and Construction; Hospitals, Animal; Humans; Immunocompromised Host; Male; Parenteral Nutrition, Total
TL;DR:
The key features of this outbreak were the multiple species affected, the increased morbidity in immunocompromised neonates, and the failure of implemented control measures to contain the disease.
(via Semantic Scholar)
Source: Crossref
Added: August 4, 2019
1997 conference paper
Preventative immunology
In N. W. Rantanen & M. L. Hauser (Eds.), Proceedings of the 1997 Dubai International Equine Symposium: The diagnosis and treatment of respiratory disease (pp. 89–106). Neyenesch Printers Inc.
Ed(s): N. Rantanen & M. Hauser
Source: NC State University Libraries
Added: August 4, 2019
1997 journal article
The equine immune response to endometrial cups
Journal of Reproductive Immunology, 34(3), 203–216.
author keywords: horse; endometrial cups; pregnancy; reproductive-immunity
MeSH headings : Animals; Chorion / cytology; Chorion / immunology; Endometrium / anatomy & histology; Endometrium / immunology; Female; Histocompatibility Antigens Class I / metabolism; Horses / anatomy & histology; Horses / immunology; Leukocytes / immunology; Male; Maternal-Fetal Exchange / immunology; Placentation / immunology; Pregnancy; Pregnancy, Animal / immunology
TL;DR:
Unique features of equine placentation make it exceptionally well-suited to studying maternal immunological interactions with the fetus.
(via Semantic Scholar)
Source: Crossref
Added: July 27, 2019
1996 journal article
Expression of major histocompatibility complex antigen and timing of invasion by equine chorionic girdle cells cultured on Matrigel
Biology of Reproduction, 54(1), 219–223.
MeSH headings : Animals; Antigens / metabolism; Cell Movement; Cells, Cultured; Chorionic Gonadotropin / biosynthesis; Collagen; Drug Combinations; Endometrium / cytology; Female; Histocompatibility Antigens Class I / metabolism; Horses; Laminin; Placentation; Pregnancy; Proteoglycans; Time Factors; Trophoblasts / cytology; Trophoblasts / immunology
TL;DR:
Neither the timing of invasion nor MHCI expression by chorionic girdle cells on Matrigel mimicked what occurs in vivo, so it is likely that the in utero environment plays a role in regulating these two characteristics of equine chorionics.
(via Semantic Scholar)
Source: Crossref
Added: August 4, 2019
1996 journal article
Positive selection of EqCD8+ precursors increases equine lymphokine-activated killing
Veterinary Immunology and Immunopathology, 53(1-2), 1–13.
author keywords: cytotoxicity; CD8; natural killing; horses
MeSH headings : Animals; Antibodies, Monoclonal / immunology; CD8 Antigens / immunology; CD8-Positive T-Lymphocytes / immunology; Cell Differentiation / immunology; Cytotoxicity, Immunologic / immunology; Fluorescent Antibody Technique, Indirect; Hematopoietic Stem Cells / immunology; Histocompatibility Antigens Class I / immunology; Histocompatibility Antigens Class II / immunology; Horses; Killer Cells, Lymphokine-Activated / immunology; Lymphocyte Activation / immunology
TL;DR:
The results indicate that positive selection of LAK precursors using an anti-EqCD8 (CVS8) antibody greatly increases LAK cytotoxicity.
(via Semantic Scholar)
Source: Crossref
Added: July 27, 2019
1996 journal article
Summary Report of the Second Equine Leucocyte Antigen Workshop
Veterinary Immunology and Immunopathology, 54(1-4), 159–161.
MeSH headings : Animals; Histocompatibility Antigens / immunology; Horses / immunology
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Crossref
Added: July 27, 2019
1996 journal article
Susceptibility of Equine Chorionic Girdle Cells to Lymphokine-Activated Killer Cell Activity
American Journal of Reproductive Immunology, 36(3), 184–190.
MeSH headings : Animals; Chorion / cytology; Chorion / immunology; Cytotoxicity, Immunologic; Horses; Immunity, Innate; Killer Cells, Lymphokine-Activated / immunology; Trophoblasts / immunology
TL;DR:
The susceptibility of cultured chorionic girdle cells to LAK cell cytotoxicity was tested in order to evaluate the role of this type of cytotoxic cells in the life‐cycle of endometrial cup tissue.
(via Semantic Scholar)
Source: Crossref
Added: July 27, 2019
1995 journal article
Abnormal patterns of equine leucocyte differentiation antigen expression in SCID foals suggests the phenotype of normal equine NK cells
Immunology, 84(3), 495–499.
Source: NC State University Libraries
Added: August 4, 2019
1995 journal article
Metalloproteinase Activity has a Role in Equine Chorionic Girdle Cell Invasion1
Biology of Reproduction, 53(4), 800–805.
MeSH headings : Animals; Aprotinin / pharmacology; Cell Movement; Cells, Cultured; Collagen; Drug Combinations; Embryo Implantation; Extracellular Matrix; Female; Horses; Laminin; Leucine / analogs & derivatives; Leucine / pharmacology; Metalloendopeptidases / antagonists & inhibitors; Metalloendopeptidases / metabolism; Phenanthrolines / pharmacology; Pregnancy; Protease Inhibitors / pharmacology; Proteoglycans; Trophoblasts / cytology
TL;DR:
Results indicated that equine chorionic girdle cells have matrix-degrading capabilities through metalloproteinase activity, suggesting a similar mechanism of implantation to mouse and human trophoblast invasion.
(via Semantic Scholar)
Source: Crossref
Added: July 27, 2019
1995 journal article
Monoclonal antibodies specific for equine IgG sub-isotypes including an antibody which recognizes B lymphocytes
Veterinary Immunology and Immunopathology, 47(3-4), 239–251.
MeSH headings : Animals; Antibodies, Monoclonal / biosynthesis; Antibodies, Monoclonal / immunology; Antibody Specificity / immunology; B-Lymphocytes / immunology; Blotting, Western / veterinary; Chromatography, Affinity / veterinary; Electrophoresis, Polyacrylamide Gel / veterinary; Enzyme-Linked Immunosorbent Assay / veterinary; Epitopes / immunology; Fluorescent Antibody Technique, Indirect / veterinary; Horses / blood; Horses / immunology; Immunodiffusion / veterinary; Immunoglobulin G / immunology; Immunoglobulin Isotypes / immunology; Mice; Mice, Inbred BALB C; Molecular Weight
TL;DR:
The production and characterization of two Mabs that recognize an IgG sub-isotype with the characteristics of IgG(ab) is described, suggesting either that equine IgD may share a common antigenic epitope with an Ig g sub- isotype, or that a large proportion of equine B lymphocytes may express an Igg sub-ISotype on their surface.
(via Semantic Scholar)
Source: Crossref
Added: July 27, 2019
1995 conference paper
Receptor interactions in equine lymphokine-activated killing
In H. Nakajima, W. Plowright, & W. Publications (Eds.), Equine Infectious Diseases VII; Proceedings (pp. 133–138). Newmarket: R & W Publications.
Ed(s): H. Nakajima, W. Plowright & W. Publications
Source: NC State University Libraries
Added: August 4, 2019
1994 journal article
Correlation between monoclonal antibody reactivity and expression of CD4 and CD8α genes in the horse
Veterinary Immunology and Immunopathology, 42(1), 61–69.
MeSH headings : Animals; Antibodies, Monoclonal / immunology; CD4 Antigens / genetics; CD4 Antigens / immunology; CD8 Antigens / genetics; CD8 Antigens / immunology; DNA Probes; Gene Expression; Genes; Horses / immunology; Nucleic Acid Hybridization; RNA / biosynthesis; T-Lymphocytes / immunology
TL;DR:
The results suggest that the equine CD4 and CD8 alpha genes are more closely related to the human than to the murine counterparts, and support the assignment of the CD3 and CD4 specificities to the antibodies listed above.
(via Semantic Scholar)
Source: Crossref
Added: July 27, 2019
1994 journal article
Polymorphic expression of an equine T lymphocyte and neutrophil subset marker
Veterinary Immunology and Immunopathology, 42(1), 83–89.
MeSH headings : Animals; Antibodies, Monoclonal / analysis; Antigens, Surface / immunology; Biomarkers; Flow Cytometry / veterinary; Horses / immunology; Immunophenotyping; Lymph Nodes / immunology; Molecular Weight; Neutrophils / immunology; Polymorphism, Genetic; T-Lymphocytes / immunology; Thymus Gland / immunology
TL;DR:
A group of antibodies recognize a 22 kDa antigen, which is present on a large subset of T lymphocytes and neutrophils, and on medullary thymocytes, and the antigen is polymorphic in its expression, and three equine phenotypes could be identified using the described antibodies.
(via Semantic Scholar)
Source: Crossref
Added: August 4, 2019
1994 journal article
Report of the First International Workshop on Equine Leucocyte Antigens, Cambridge, UK, July 1991
Veterinary Immunology and Immunopathology, 42(1), 3–60.
MeSH headings : Animals; Antigens, CD / classification; Antigens, CD / immunology; B-Lymphocytes / immunology; Histocompatibility Antigens / classification; Histocompatibility Antigens / immunology; Horses / immunology; International Cooperation; T-Lymphocytes / immunology; Terminology as Topic; United Kingdom
TL;DR:
There are still substantial gaps in the armory of reagents available to study equine leucocyte biology, and further definition of the structure, function, and genetics of the antigens identified by the workshop clusters and other molecules of immunological importance will be a goal of future workshops.
(via Semantic Scholar)
Source: Crossref
Added: July 27, 2019
1994 journal article
Variation of MHC II expression on canine lymphocytes with age
Tissue Antigens, 43(3), 179–183.
MeSH headings : Aging / immunology; Animals; Antibodies, Monoclonal / immunology; Antigens, Surface / analysis; Antigens, Surface / immunology; Dogs / immunology; Female; Histocompatibility Antigens / analysis; Histocompatibility Antigens / immunology; Histocompatibility Antigens Class I; Histocompatibility Antigens Class II / analysis; Histocompatibility Antigens Class II / immunology; Lymphocyte Subsets / immunology; Male; Membrane Glycoproteins / analysis; Membrane Glycoproteins / immunology; Mice; Mice, Inbred BALB C; Thy-1 Antigens
Source: Crossref
Added: July 27, 2019
1993 journal article
A comparative review of human and equine leucocyte differentiation antigens
British Veterinary Journal, 149(1), 31–49.
MeSH headings : Animals; Antigens, CD / chemistry; Antigens, CD / immunology; Antigens, Differentiation / chemistry; Antigens, Differentiation / immunology; Horses / immunology; Humans; Leukocytes / immunology; Species Specificity
TL;DR:
Equine researchers have started to develop similar reagents, which now offer a powerful tool to investigators of equine immunology and disease.
(via Semantic Scholar)
Source: Crossref
Added: July 27, 2019
1993 journal article
Clinico-pathological diagnosis of immunodeficiency
Equine Veterinary Education, 5(1), 30–32.
Source: Crossref
Added: August 4, 2019
1993 journal article
Combined immunodeficiency in 3 foals
Equine Veterinary Education, 5(1), 14–18.
TL;DR:
This report describes 3 cases of CID presented to the School of Veterinary Medicine, University of Wisconsin-Madison between May and August of 1992, which included a foal with severe lymphopenia and signs of respiratory disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Crossref
Added: August 4, 2019
1993 journal article
Equine T-lymphocyte MHC II expression: variation with age and subset
Veterinary Immunology and Immunopathology, 35(3-4), 225–238.
MeSH headings : Aging / immunology; Animals; Antibodies, Monoclonal / biosynthesis; Antibodies, Monoclonal / immunology; CD4-Positive T-Lymphocytes / immunology; Electrophoresis, Polyacrylamide Gel; Flow Cytometry; Fluorescent Antibody Technique; Histocompatibility Antigens Class II / immunology; Horses / immunology; Mice; Mice, Inbred BALB C; T-Lymphocytes / immunology; T-Lymphocytes, Regulatory / immunology
TL;DR:
It was found that far fewer lymphocytes express MHC II in neonatal foals than in adult horses, and an increase with age was demonstrated, and it was proposed that this change may be associated with the development of a memory T-lymphocyte population.
(via Semantic Scholar)
Source: Crossref
Added: July 27, 2019
1993 journal article
Familial occurrence of narcolepsy in Miniature Horses
Equine Veterinary Journal, 25(6), 483–487.
author keywords: HORSE; NARCOLEPSY; CATAPLEXY; NEUROTRANSMITTERS; INHERITANCE
MeSH headings : Animals; Atropine; Breeding; Electroencephalography / veterinary; Female; Horse Diseases / diagnosis; Horse Diseases / genetics; Horses; Imipramine; Male; Narcolepsy / diagnosis; Narcolepsy / genetics; Narcolepsy / veterinary; Neostigmine; Neurologic Examination / veterinary; Neurotransmitter Agents / cerebrospinal fluid; Pedigree; Physostigmine / analogs & derivatives
TL;DR:
Investigation of closely related Miniature Horses with a history of excessive sleepiness, depression and episodes of collapse has shown that narcolepsy is a rare but distinct syndrome in the Miniature Horse, and that the cases described here appear to represent a familial occurrence of the disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
1993 journal article
Moleculaar cloning of equine CD44 cDNA by a COS cell expression system
Immunogenetics, 37(6).
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; DNA / genetics; Horses / genetics; Horses / immunology; Membrane Glycoproteins / genetics; Molecular Sequence Data; Receptors, Lymphocyte Homing / genetics; Sequence Alignment; Species Specificity
TL;DR:
This poster presents a poster presented at the 2016 American Academy of Veterinary Medicine conference on “Advances in Veterinary Microbiology and Pathology: Advances in Immunology and Pathological Investigation of Animal Physiology and Genetics Research.
(via Semantic Scholar)
Source: Crossref
Added: July 27, 2019
1992 conference paper
Equine T lymphocytes
In W. Plowright, P. D. Rossdale, & J. F. Wade (Eds.), Sixth International Equine Infectious Disease Conference Proceedings (pp. 113–120). Newmarket: R & W Publications.
Ed(s): W. Plowright, P. Rossdale & J. Wade
Source: NC State University Libraries
Added: August 4, 2019
1991 journal article
A study of bovine and equine immunoglobulin levels in pony foals fed bovine colostrum
Equine Veterinary Journal, 23(2), 116–118.
MeSH headings : Animals; Animals, Newborn / immunology; Cattle; Colostrum / immunology; Horses / immunology; Immunoglobulin G / analysis; Immunoglobulin G / biosynthesis; Immunoglobulins / administration & dosage; Immunoglobulins / analysis; Immunoglobulins / biosynthesis; Specific Pathogen-Free Organisms
TL;DR:
This study characterises the uptake of bovine colostral immunoglobulin and production of endogenous immunoglOBulin, in 10 SPF foals and examines the efficiency of transfer, and rate of elimination of boIgG1 by the foal.
(via Semantic Scholar)
Source: Crossref
Added: July 27, 2019
1991 journal article
Evidence for MHC class-l restricted cytotoxicity in the one-way, primary mixed lymphocyte reaction
Equine Veterinary Journal, 23(S12), 30–34.
TL;DR:
Allospecific cytotoxicity, demonstrated against Con A stimulated peripheral blood mononuclear cells (PBMC) in a 6 h chromium-release assay, was present from approximately 72 to 168 h of primary culture and peaked between 120 and 168 h.
(via Semantic Scholar)
Source: Crossref
Added: July 27, 2019
1991 journal article
Haematological changes and equine lymphocyte subpopulation kinetics during primary infection and attempted re-infection of specific pathogen free foals with EHV-1
Equine Veterinary Journal, 23(S12), 35–40.
TL;DR:
Four specific pathogen- (Equid Herpesvirus type 1 [EHV-1]) free foals aged 2 to 3 months were intranasally inoculated with 7 times 107 p.f.u. of EHV- 1, suggesting an effective immune response or subclinical infection.
(via Semantic Scholar)
Source: Crossref
Added: July 27, 2019
1991 journal article
Idiopathic thrombocytopaenia in a Holstein bull
Canadian Veterinary Journal, 32, 559–561.
Source: NC State University Libraries
Added: August 4, 2019
1991 journal article
The raising of equine colostrum-deprived foals; maintenance and assessment of specific pathogen (EHV-1/4) free status
Equine Veterinary Journal, 23(2), 111–115.
MeSH headings : Animals; Animals, Newborn / immunology; Anti-Bacterial Agents / therapeutic use; Antibodies, Viral / blood; Cattle; Colostrum / chemistry; Colostrum / immunology; Electrolytes / analysis; Female; Herpesviridae / immunology; Herpesviridae Infections / immunology; Herpesviridae Infections / veterinary; Herpesvirus 1, Equid / immunology; Horse Diseases / immunology; Horses / immunology; Immunity, Maternally-Acquired; Pregnancy; Specific Pathogen-Free Organisms / immunology
TL;DR:
None of the specific pathogen free (SPF) foals showed evidence of infection with EHV-1/4 in terms of clinical disease, virus isolation, sero-conversion or specific lymphocyte transformation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: Crossref
Added: July 27, 2019
1991 journal article
Three monoclonal antibodies identifying antigenson all equine T-lymphocytes, and two mutually exclusive T-lymphocyte subsets
Immunology, 74, 251–257.
Source: NC State University Libraries
Added: August 4, 2019
1990 journal article
An experimental model of hypochloraemic metabolic alkalosis caused by diversion of abomasal outflow in sheep
American Journal of Veterinary Research, 51, 1715–1722.
Source: NC State University Libraries
Added: August 4, 2019
1990 chapter
Cardiovascular Diseases
In B. P. Smith (Ed.), Large Animal Internal Medicine (1st ed., pp. 454–488). Pennsylvania: CV Mosby Co.
Ed(s): B. Smith
Source: NC State University Libraries
Added: August 4, 2019
1990 journal article
Renal Regulation of Electrolyte and Acid- Base Balance in Ruminants
Veterinary Clinics of North America: Food Animal Practice, 6(1), 1–28.
MeSH headings : Acid-Base Equilibrium / physiology; Acid-Base Imbalance / metabolism; Acid-Base Imbalance / veterinary; Acute Kidney Injury / metabolism; Acute Kidney Injury / veterinary; Animals; Electrolytes / urine; Humans; Kidney / physiology; Osmolar Concentration; Ruminants / metabolism; Water-Electrolyte Balance / physiology; Water-Electrolyte Imbalance / metabolism; Water-Electrolyte Imbalance / veterinary
TL;DR:
The kidney maintains volume, electrolyte, and acid-base homeostasis in the ruminant in response to differing dietary intakes and disease states and the interpretation of urinary excretion data is reviewed.
(via Semantic Scholar)
Source: Crossref
Added: July 27, 2019
1990 journal article
Renal net acid and electrolyte excretion in an experimental model of hypochloraemic metabolic alkalosis in sheep
American Journal of Veterinary Research, 51, 1723–1731.
Source: NC State University Libraries
Added: August 4, 2019
1990 journal article
Total parenteral nutrition in a neonatal llama
Journal of the American Veterinary Medical Association, 196, 319–322.
Source: NC State University Libraries
Added: August 4, 2019
1989 journal article
A case of ataxia in a Thoroughbred filly
Equine Veterinary Education, 1(2), 85–88.
Source: Crossref
Added: July 27, 2019
1989 journal article
Cerebrospinal fluid eosinophilia and ataxia in five llamas
Veterinary Record, 124(12), 302–305.
MeSH headings : Animals; Artiodactyla; Ataxia / cerebrospinal fluid; Ataxia / veterinary; Camelids, New World; Eosinophilia / cerebrospinal fluid; Eosinophilia / veterinary; Female; Parasitic Diseases / cerebrospinal fluid; Parasitic Diseases, Animal; Pregnancy; Pregnancy Complications, Infectious / cerebrospinal fluid; Pregnancy Complications, Infectious / veterinary
TL;DR:
The results demonstrate the value of an examination of cerebrospinal fluid in the evaluation of neurological disease in llamas and demonstrate the importance of combined anthelmintic and anti-inflammatory therapy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
1989 journal article
The neurological evaluation of horses
Equine Veterinary Education, 1(2), 94–101.
Source: Crossref
Added: July 27, 2019
1985 journal article
Successful treatment of traumatic oesophageal rupture with severe cellulitis in a mare
Veterinary Record, 116(20), 544–545.
MeSH headings : Animals; Cellulitis / therapy; Cellulitis / veterinary; Combined Modality Therapy; Debridement; Drainage; Esophagus / injuries; Female; Gentamicins / therapeutic use; Horse Diseases / therapy; Horses; Penicillin G Procaine / therapeutic use; Povidone-Iodine / therapeutic use; Rupture
TL;DR:
A five-year-old standardbred mare suffered a cervical oesophageal rupture subsequent to a kick and marked cellulitis and extensive soft tissue damage resulted.
(via Semantic Scholar)
Source: Crossref
Added: July 27, 2019
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