Daphne Sze
College of Engineering
Works (3)
Updated: July 5th, 2023 14:22
2022 article
Towards a standardized multi-tissue decellularization protocol for the derivation of extracellular matrix materials
Biehl, A., Martins, A. M. G. M., Davis, Z. G. G., Sze, D., Collins, L., Mora-Navarro, C., … Freytes, D. O. O. (2022, December 12). BIOMATERIALS SCIENCE, Vol. 12.
MeSH headings : Tissue Engineering / methods; Proteomics; Extracellular Matrix / chemistry; Hydrogels / chemistry; Biocompatible Materials / analysis; Tissue Scaffolds
TL;DR:
The present study is the first proof-of-concept towards the development of a standardized protocol that can be used to derive multiple ECM biomaterials via a previously established automated system and showed gelation and rheological properties consistent with previous ECM hydrogels.
(via Semantic Scholar)
open access via pubs.rsc.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 3, 2023
2021 journal article
Bioreactors for Vocal Fold Tissue Engineering
TISSUE ENGINEERING PART B-REVIEWS, 28(1), 182–205.
author keywords: vocal fold; bioreactor; lamina propria; gene expression; fibrosis; inflammation
MeSH headings : Biocompatible Materials; Bioreactors; Cicatrix; Humans; Tissue Engineering / methods; Vocal Cords / pathology; Vocal Cords / physiology
TL;DR:
An in-depth analysis of VF bioreactor data to date reveals that mechanical stimulation significantly influences cell viability and the expression of pro-inflammatory and pro-fibrotic genes in vitro.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: March 29, 2021
2021 journal article
Transcriptome-targeted analysis of human peripheral blood-derived macrophages when cultured on biomaterial meshes
BIOMEDICAL MATERIALS, 16(2).
author keywords: surgical meshes; macrophage polarization; biomaterials; targeted transcriptome; poly-4-hydroxybutyrate (P4HB); polypropylene
MeSH headings : Anti-Inflammatory Agents / chemistry; Biocompatible Materials / chemistry; Cell Culture Techniques; Cell Differentiation; Cell Separation; Cells, Cultured; Flow Cytometry; Gene Expression Profiling; Humans; Hydroxybutyrates; Immunity, Innate; In Vitro Techniques; Inflammation; Macrophages / drug effects; Macrophages / metabolism; Materials Testing; Monocytes / cytology; Phenotype; Polypropylenes / chemistry; Prostheses and Implants; RNA / metabolism; Surgical Mesh; Tissue Scaffolds; Transcriptome; Treatment Outcome; Up-Regulation; Wound Healing
TL;DR:
In vitro evidence is provided for the early transcriptomic targeted signature of human Mφs upon two commonly used surgical meshes and suggests a transition from an inflammatory to a non-inflammatory phenotype by P4HB as well as an upregulation of genes annotated under the pathogen response pathway.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 16, 2021