Daphne Sze

College of Engineering

Works (3)

Updated: July 5th, 2023 14:22

2022 journal article

Towards a standardized multi-tissue decellularization protocol for the derivation of extracellular matrix materials

Biomaterials Science, 11(2), 641–654.

By: A. Biehl  n, A. Gracioso Martins n, Z. Davis n , D. Sze n, L. Collins n , C. Mora-Navarro *, M. Fisher n , D. Freytes n 

MeSH headings : Tissue Engineering / methods; Proteomics; Extracellular Matrix / chemistry; Hydrogels / chemistry; Biocompatible Materials / analysis; Tissue Scaffolds
topics (OpenAlex): Tissue Engineering and Regenerative Medicine; Electrospun Nanofibers in Biomedical Applications; Bone Tissue Engineering Materials
TL;DR: The present study is the first proof-of-concept towards the development of a standardized protocol that can be used to derive multiple ECM biomaterials via a previously established automated system and showed gelation and rheological properties consistent with previous ECM hydrogels. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: January 3, 2023

2021 journal article

Bioreactors for Vocal Fold Tissue Engineering

Tissue Engineering Part B: Reviews, 28(1), 182–205.

By: A. Gracioso Martins n, A. Biehl n, D. Sze n & D. Freytes n 

author keywords: vocal fold; bioreactor; lamina propria; gene expression; fibrosis; inflammation
MeSH headings : Biocompatible Materials; Bioreactors; Cicatrix; Humans; Tissue Engineering / methods; Vocal Cords / pathology; Vocal Cords / physiology
topics (OpenAlex): Voice and Speech Disorders; Tracheal and airway disorders; Dysphagia Assessment and Management; 3D Printing in Biomedical Research
TL;DR: An in-depth analysis of VF bioreactor data to date reveals that mechanical stimulation significantly influences cell viability and the expression of pro-inflammatory and pro-fibrotic genes in vitro. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: March 29, 2021

2021 journal article

Transcriptome-targeted analysis of human peripheral blood-derived macrophages when cultured on biomaterial meshes

Biomedical Materials, 16(2), 025006.

By: C. Mora-Navarro n, E. Ozpinar n , D. Sze n, D. Martin * & D. Freytes n 

author keywords: surgical meshes; macrophage polarization; biomaterials; targeted transcriptome; poly-4-hydroxybutyrate (P4HB); polypropylene
MeSH headings : Anti-Inflammatory Agents / chemistry; Biocompatible Materials / chemistry; Cell Culture Techniques; Cell Differentiation; Cell Separation; Cells, Cultured; Flow Cytometry; Gene Expression Profiling; Humans; Hydroxybutyrates; Immunity, Innate; In Vitro Techniques; Inflammation; Macrophages / drug effects; Macrophages / metabolism; Materials Testing; Monocytes / cytology; Phenotype; Polypropylenes / chemistry; Prostheses and Implants; RNA / metabolism; Surgical Mesh; Tissue Scaffolds; Transcriptome; Treatment Outcome; Up-Regulation; Wound Healing
topics (OpenAlex): Wound Healing and Treatments; Mesenchymal stem cell research; Electrospun Nanofibers in Biomedical Applications
TL;DR: In vitro evidence is provided for the early transcriptomic targeted signature of human Mφs upon two commonly used surgical meshes and suggests a transition from an inflammatory to a non-inflammatory phenotype by P4HB as well as an upregulation of genes annotated under the pathogen response pathway. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: January 16, 2021

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