Works (11)

Updated: April 24th, 2025 04:28

2024 article

Profiling the cancer-prone microenvironment in a zebrafish model for MPNST

Cero, C., House, J. S., Verdi, V., Ferguson, J. L., Jima, D. D., Selmek, A. A., … Shive, H. R. (2024, November 7). Oncogene, Vol. 11.

By: C. Cero*, J. House*, V. Verdi*, J. Ferguson*, D. Jima n, A. Selmek*, O. Patania, J. Dwyer* ...

MeSH headings : Animals; Zebrafish / genetics; Tumor Microenvironment / genetics; Disease Models, Animal; Humans; Gene Expression Regulation, Neoplastic; Neurofibrosarcoma / genetics; Neurofibrosarcoma / pathology; Neurofibrosarcoma / metabolism; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism; Transcriptome; Gene Expression Profiling; Cell Adhesion Molecules / genetics; Cell Adhesion Molecules / metabolism
topics (OpenAlex): Aquaculture disease management and microbiota; Cancer, Hypoxia, and Metabolism; Zebrafish Biomedical Research Applications
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10. Reduced Inequalities (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 7, 2024

2024 article

Taxanorm: a novel taxa-specific normalization approach for microbiome data

Wang, Z., Lloyd, D., Zhao, S., & Motsinger-Reif, A. (2024, September 16). BMC Bioinformatics.

author keywords: Sequencing depth; Normalization; Microbiome; High-throughput sequencing
MeSH headings : Microbiota / genetics; High-Throughput Nucleotide Sequencing / methods; Humans; Algorithms
topics (OpenAlex): Genomics and Phylogenetic Studies; Gut microbiota and health; Gene expression and cancer classification
Source: Web Of Science
Added: September 23, 2024

2023 article

Application of Ion Mobility Spectrometry–Mass Spectrometry for Compositional Characterization and Fingerprinting of a Library of Diverse Crude Oil Samples

Cordova, A. C., Dodds, J. N., Tsai, H.-H. D., Lloyd, D. T., Roman-Hubers, A. T., Wright, F. A., … Rusyn, I. (2023, August 2). Environmental Toxicology and Chemistry.

By: A. Cordova*, J. Dodds*, H. Tsai*, D. Lloyd n, A. Roman-Hubers*, F. Wright n, W. Chiu*, T. McDonald* ...

author keywords: Analytical chemistry; Environmental chemistry; Hazard; risk assessment; Mixtures; Oil spills
MeSH headings : Petroleum / analysis; Ion Mobility Spectrometry; Mass Spectrometry; Gas Chromatography-Mass Spectrometry / methods; Biomarkers
topics (OpenAlex): Petroleum Processing and Analysis; Mass Spectrometry Techniques and Applications; Hydrocarbon exploration and reservoir analysis
TL;DR: It is found that IMS-MS data has complementary advantages for fingerprinting and characterization of diverse crude oils and that the proposed polycyclic aromatic hydrocarbon (PAH) biomarkers can be used for rapid exposure characterization. (via Semantic Scholar)
Source: Web Of Science
Added: September 5, 2023

2022 article

Clomifene and Assisted Reproductive Technology in Humans Are Associated with Sex-Specific Offspring Epigenetic Alterations in Imprinted Control Regions

Lloyd, D. T., Skinner, H. G., Maguire, R., Murphy, S. K., Motsinger-Reif, A. A., Hoyo, C., & House, J. S. (2022, September 9). International Journal of Molecular Sciences, Vol. 23.

author keywords: differentially methylated regions; adverse offspring outcomes; infertility
MeSH headings : Child; Clomiphene; DNA Methylation; Female; Genomic Imprinting; Humans; Male; Reproductive Techniques, Assisted / adverse effects; Retrospective Studies
topics (OpenAlex): Assisted Reproductive Technology and Twin Pregnancy; Prenatal Screening and Diagnostics; Genetic Syndromes and Imprinting
TL;DR: The results suggest that the increased risk of adverse outcomes in offspring conceived through ART may be due in part to altered methylation of ICRs, and larger studies utilizing epigenome-wide interrogation are warranted. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 3, 2022

2022 article

Sex-specific DNA methylation and associations with in utero tobacco smoke exposure at nuclear-encoded mitochondrial genes

King, D. E., Sparling, A. C., Lloyd, D., Satusky, M. J., Martinez, M., Grenier, C., … Murphy, S. K. (2022, March 3). Epigenetics, Vol. 3.

By: D. King*, A. Sparling*, D. Lloyd n, M. Satusky*, M. Martinez*, C. Grenier*, C. Bergemann*, R. Maguire n ...

author keywords: Sex differences; mitochondria; DNA methylation; in utero smoke exposure
MeSH headings : Female; Humans; Male; Adenosine Triphosphate; DNA Methylation; Genes, Mitochondrial; Hormones; Reactive Oxygen Species; Tobacco Smoke Pollution; Sex Factors; Maternal Exposure
topics (OpenAlex): Epigenetics and DNA Methylation; Birth, Development, and Health; Health, Environment, Cognitive Aging; RNA modifications and cancer
TL;DR: The findings suggest that sex-specific DNA methylation may help establish sex differences in expression and function and thatsex-specific alterations inDNA methylation in response to exposures could contribute to sex-variable toxicological responses. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 21, 2022

2021 article

Data Processing Workflow to Identify Structurally Related Compounds in Petroleum Substances Using Ion Mobility Spectrometry–Mass Spectrometry

Roman-Hubers, A. T., Cordova, A. C., Aly, N. A., McDonald, T. J., Lloyd, D. T., Wright, F. A., … Rusyn, I. (2021, June 16). Energy & Fuels, Vol. 7.

By: A. Roman-Hubers*, A. Cordova*, N. Aly*, T. McDonald*, D. Lloyd n, F. Wright n, E. Baker n, W. Chiu*, I. Rusyn*

topics (OpenAlex): Petroleum Processing and Analysis; Mass Spectrometry Techniques and Applications; Analytical Chemistry and Chromatography
TL;DR: This work demonstrates how rapid untargeted IMS-MS analysis and the proposed data processing workflow can be used to provide confident compositional characterization of hydrocarbon-containing substances. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: July 26, 2021

2021 article

Environmental impacts of Hurricane Florence flooding in eastern North Carolina: temporal analysis of contaminant distribution and potential human health risks

Aly, N. A., Casillas, G., Luo, Y.-S., McDonald, T. J., Wade, T. L., Zhu, R., … Rusyn, I. (2021, April 24). Journal of Exposure Science & Environmental Epidemiology.

By: N. Aly*, G. Casillas*, Y. Luo*, T. McDonald*, T. Wade*, R. Zhu*, G. Newman*, D. Lloyd n ...

author keywords: Disaster research response; Superfund; Chemical contaminants
MeSH headings : Cyclonic Storms; Environmental Monitoring; Gas Chromatography-Mass Spectrometry; Humans; Metals; North Carolina / epidemiology; Soil
topics (OpenAlex): Tropical and Extratropical Cyclones Research; Disaster Management and Resilience; Wind and Air Flow Studies
TL;DR: PAH and metals detected downstream from the coal ash storage pond that leaked were detected and were indicative of a pyrogenic source of contamination and PAH at these sites were of human health concern because cancer risk values exceeded 1 × 10−6 threshold. (via Semantic Scholar)
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Source: Web Of Science
Added: May 24, 2021

2020 article

Associations between maternal obesity, gestational cytokine levels and child obesity in the NEST cohort

Maguire, R. L., House, J. S., Lloyd, D. T., Skinner, H. G., Allen, T. K., Raffi, A. M., … Hoyo, C. (2020, December 30). Pediatric Obesity, Vol. 16.

By: R. Maguire n, J. House n, D. Lloyd n, H. Skinner n, T. Allen*, A. Raffi n, D. Skaar n, S. Park n ...

Contributors: R. Maguire n, J. House n, D. Lloyd n, H. Skinner n, T. Allen*, A. Raffi n, D. Skaar n, S. Park n ...

author keywords: cytokines; maternal obesity; childhood obesity
MeSH headings : Black or African American; Body Mass Index; Child; Child, Preschool; Cohort Studies; Cytokines / blood; Female; Humans; Obesity, Maternal / epidemiology; Pediatric Obesity / epidemiology; Pregnancy; White People
topics (OpenAlex): Reproductive System and Pregnancy; Gestational Diabetes Research and Management; Adipokines, Inflammation, and Metabolic Diseases
TL;DR: Although maternal systemic inflammation is hypothesized to link maternal pre‐pregnancy obesity to offspring metabolic dysfunction, patient empirical data are limited. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 19, 2021

2020 article

Classification of estrogenic compounds by coupling high content analysis and machine learning algorithms

Mukherjee, R., Beykal, B., Szafran, A. T., Onel, M., Stossi, F., Mancini, M. G., … Pistikopoulos, E. N. (2020, September 24). PLoS Computational Biology.

MeSH headings : Algorithms; Cell Line; Estrogens / classification; Estrogens / metabolism; Humans; Machine Learning; Receptors, Estrogen / metabolism
topics (OpenAlex): Computational Drug Discovery Methods; Molecular Biology Techniques and Applications; Estrogen and related hormone effects
TL;DR: A machine learning pipeline for rapid, accurate, and sensitive assessment of the endocrine-disrupting potential of benchmark chemicals based on data generated from high content analysis showed that highly accurate and generalized classification models with a minimum number of features can be constructed without loss of generality. (via Semantic Scholar)
Source: Web Of Science
Added: October 26, 2020

2020 article

Low‐Dose Silver Nanoparticle Surface Chemistry and Temporal Effects on Gene Expression in Human Liver Cells

House, J. S., Bouzos, E., Fahy, K. M., Francisco, V. M., Lloyd, D. T., Wright, F. A., … Wheeler, K. E. (2020, March 29). Small, Vol. 16.

By: J. House n, E. Bouzos*, K. Fahy*, V. Francisco*, D. Lloyd n, F. Wright n, A. Motsinger‐Reif*, P. Asuri*, K. Wheeler*

Contributors: J. House n, E. Bouzos*, K. Fahy*, V. Francisco*, D. Lloyd n, F. Wright n, A. Motsinger-Reif*, P. Asuri*, K. Wheeler*

author keywords: nanotoxicity; silver nanoparticles; transcriptomics
MeSH headings : Gene Expression / drug effects; Hepatocytes / drug effects; Humans; Metal Nanoparticles / chemistry; Silver; Surface Properties; Time Factors
topics (OpenAlex): Nanoparticles: synthesis and applications; Graphene and Nanomaterials Applications; Healthcare and Environmental Waste Management
TL;DR: Universal to all surface coatings, AgNP-treated cells responded by inactivating proliferation and enabling cell cycle checkpoints, which provide a foundation for understanding hepatic response to low-dose AgNPs for future risk assessment. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 14, 2020

2020 article

Risk Characterization of Environmental Samples UsingIn VitroBioactivity and Polycyclic Aromatic Hydrocarbon Concentrations Data

Chen, Z., Lloyd, D., Zhou, Y.-H., Chiu, W. A., Wright, F. A., & Rusyn, I. (2020, October 28). Toxicological Sciences.

author keywords: polycyclic aromatic hydrocarbons; mixtures toxicology; in vitro models; iPSC; humanized models; human risk assessment; risk assessment; new approach methods; bioactivity; spatial analysis
MeSH headings : Cyclonic Storms; Endothelial Cells; Environmental Exposure / adverse effects; Environmental Monitoring; Humans; Polycyclic Aromatic Hydrocarbons / toxicity
topics (OpenAlex): Toxic Organic Pollutants Impact; Effects and risks of endocrine disrupting chemicals; Carcinogens and Genotoxicity Assessment
TL;DR: This work sets the stage for identification of the areas of concern and direct quantitative risk characterization based on bioactivity data, thereby providing an important supplement to traditional individual chemical analyses by shedding light on constituents that may be missed from targeted chemical monitoring. (via Semantic Scholar)
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Source: Web Of Science
Added: March 15, 2021

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