Dhoha Triki

Works (3)

Updated: July 5th, 2023 14:56

2021 article

The VKORC1 ER-luminal loop mutation (Leu76Pro) leads to a significant resistance to warfarin in black rats (Rattus rattus)

Takeda, K., Ikenaka, Y., Fourches, D., Tanaka, K. D., Nakayama, S. M. M., Triki, D., … Ishizuka, M. (2021, January 10). Pesticide Biochemistry and Physiology.

By: K. Takeda *, Y. Ikenaka *, D. Fourches n, K. Tanaka*, S. Nakayama*, D. Triki n, X. Li  n, M. Igarashi *, T. Tanikawa*, M. Ishizuka *

author keywords: Vitamin K epoxide reductase; Warfarin; Rodenticide-resistance; Molecular docking; Molecular dynamics simulations
MeSH headings : Animals; Drug Resistance / genetics; Mutation; Rats; Rodenticides / toxicity; Vitamin K Epoxide Reductases / genetics; Warfarin / pharmacology
topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Eicosanoids and Hypertension Pharmacology; Receptor Mechanisms and Signaling
TL;DR: It is concluded that a single mutation of VKOR at position 76 leads to a significant resistance to warfarin by modifying the types and numbers of intermolecular interactions between the two. (via Semantic Scholar)
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Source: Web Of Science
Added: April 26, 2021

2020 article

In vitro and in vivo Evaluation of in silico Predicted Pneumococcal UDPG:PP Inhibitors

Cools, F., Triki, D., Geerts, N., Delputte, P., Fourches, D., & Cos, P. (2020, July 15). Frontiers in Microbiology.

By: F. Cools *, D. Triki n, N. Geerts *, P. Delputte *, D. Fourches n & P. Cos *

author keywords: Streptococcus pneumoniae; GalU; in silicomodeling; virulence; Galleria mellonella; novel drug target
topics (OpenAlex): Pneumonia and Respiratory Infections; Peptidase Inhibition and Analysis; Carbohydrate Chemistry and Synthesis
TL;DR: UDPG:PP inhibitors proved to have an effect on streptococcal virulence by lowering the amount of polysaccharide and thereby probably boosting recognition of this pathogen by the innate immune system. (via Semantic Scholar)
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Source: Web Of Science
Added: August 24, 2020

2019 article

Exploration of the effects of sequence variations between HIV-1 and HIV-2 proteases on their three-dimensional structures

Triki, D., Kermarrec, M., Visseaux, B., Descamps, D., Flatters, D., Camproux, A.-C., & Regad, L. (2019, December 13). Journal of Biomolecular Structure and Dynamics.

By: D. Triki n, M. Kermarrec*, B. Visseaux *, D. Descamps *, D. Flatters *, A. Camproux *, L. Regad *

author keywords: HIV-1 protease; HIV-2 protease; protease inhibitors; drug resistance; protein structure comparison
MeSH headings : HIV Protease / genetics; HIV Protease / metabolism; HIV Protease Inhibitors; HIV-1 / genetics; HIV-1 / metabolism; HIV-2 / genetics; HIV-2 / metabolism; Protein Binding
topics (OpenAlex): HIV/AIDS drug development and treatment; HIV Research and Treatment; Click Chemistry and Applications
TL;DR: The understanding of the impact of sequence variations between PR1 and PR2 on the natural resistance of HIV-2 to commercially available PIs is improved and the important role of three regions in the conservation of the catalytic region is highlighted. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: January 13, 2020

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