Dhoha Triki

Works (3)

Updated: July 5th, 2023 14:56

2021 journal article

The VKORC1 ER-luminal loop mutation (Leu76Pro) leads to a significant resistance to warfarin in black rats (Rattus rattus)

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 173.

By: K. Takeda *, Y. Ikenaka *, D. Fourches n, K. Tanaka*, S. Nakayama*, D. Triki n, X. Li  n, M. Igarashi *, T. Tanikawa*, M. Ishizuka *

author keywords: Vitamin K epoxide reductase; Warfarin; Rodenticide-resistance; Molecular docking; Molecular dynamics simulations
MeSH headings : Animals; Drug Resistance / genetics; Mutation; Rats; Rodenticides / toxicity; Vitamin K Epoxide Reductases / genetics; Warfarin / pharmacology
TL;DR: It is concluded that a single mutation of VKOR at position 76 leads to a significant resistance to warfarin by modifying the types and numbers of intermolecular interactions between the two. (via Semantic Scholar)
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Added: April 26, 2021

2020 journal article

Exploration of the effects of sequence variations between HIV-1 and HIV-2 proteases on their three-dimensional structures

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 38(17), 5014–5026.

By: D. Triki n, M. Kermarrec*, B. Visseaux *, D. Descamps *, D. Flatters *, A. Camproux *, L. Regad *

author keywords: HIV-1 protease; HIV-2 protease; protease inhibitors; drug resistance; protein structure comparison
MeSH headings : HIV Protease / genetics; HIV Protease / metabolism; HIV Protease Inhibitors; HIV-1 / genetics; HIV-1 / metabolism; HIV-2 / genetics; HIV-2 / metabolism; Protein Binding
TL;DR: The understanding of the impact of sequence variations between PR1 and PR2 on the natural resistance of HIV-2 to commercially available PIs is improved and the important role of three regions in the conservation of the catalytic region is highlighted. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
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Added: January 13, 2020

2020 journal article

In vitroandin vivoEvaluation ofin silicoPredicted Pneumococcal UDPG:PP Inhibitors

FRONTIERS IN MICROBIOLOGY, 11.

By: F. Cools *, D. Triki n, N. Geerts *, P. Delputte *, D. Fourches n & P. Cos *

author keywords: Streptococcus pneumoniae; GalU; in silicomodeling; virulence; Galleria mellonella; novel drug target
TL;DR: UDPG:PP inhibitors proved to have an effect on streptococcal virulence by lowering the amount of polysaccharide and thereby probably boosting recognition of this pathogen by the innate immune system. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 24, 2020

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