David W. Chang

Works (2)

Updated: July 5th, 2023 15:36

2019 journal article

Real-time monitoring and control of CHO cell apoptosis by in situ multifrequency scanning dielectric spectroscopy

PROCESS BIOCHEMISTRY, 80, 138–145.

By: F. Ma n, A. Zhang *, D. Chang n, O. Velev n , K. Wiltberger * & R. Kshirsagar*

author keywords: Dielectric spectroscopy; Apoptosis; Multi-frequency permittivity; Chinese Hamster Ovary (CHO) cell culture; Fed-batch; Feedback control
TL;DR: The results demonstrate that full-spectrum dielectric spectroscopy can be used as a facile tool for early detection of physiological changes and process adjustment in real-time to enhance bioreactor process productivity and robustness. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: June 4, 2019

2017 journal article

Investigation of interfacial properties of pure and mixed poloxamers for surfactant-mediated shear protection of mammalian cells

COLLOIDS AND SURFACES B-BIOINTERFACES, 156, 358–365.

By: D. Chang n, R. Fox  n, E. Hicks n, R. Ferguson*, K. Chang *, D. Osborne *, W. Hu*, O. Velev n 

author keywords: Poloxamer; Mammalian cells; Shear sensitivity; Interfacial tension; Foam stability; Bioreactors
MeSH headings : Animals; CHO Cells; Cell Survival / drug effects; Cells, Cultured; Cricetulus; Poloxamer / chemistry; Poloxamer / pharmacology; Surface Tension; Surface-Active Agents / chemistry; Surface-Active Agents / pharmacology
TL;DR: The mechanism of disruption by P407 was determined to be independent of cell-to-bubble attachment, suggesting that poloxamer adsorption to and subsequent reinforcement of the cell membrane may play a key role in protecting cells in high shear environments. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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