Drake Phelps


zebrafish, immunology, toxicology, immunotoxicology, PFAS

I'm an immunotoxicologist who is passionate about protecting human and environmental health from toxic threats, such as EDCs and PFAS.

Works (10)

Updated: July 5th, 2023 15:34

2023 journal article

Legacy and emerging per- and polyfluoroalkyl substances suppress the neutrophil respiratory burst


By: D. Phelps*, A. Palekar, H. Conley*, G. Ferrero, J. Driggers*, K. Linder*, S. Kullman n, D. Reif n ...

author keywords: Innate immunity; neutrophils; per- and polyfluoroalkyl substances (PFAS); reactive oxygen species; zebrafish
MeSH headings : Animals; Humans; Zebrafish; Neutrophils; Reactive Oxygen Species; Respiratory Burst; Fluorocarbons / toxicity; Alkanesulfonic Acids / toxicity; Environmental Pollutants
Sources: ORCID, Web Of Science
Added: February 15, 2023

2021 journal article

Monoassociation with bacterial isolates reveals the role of colonization, community complexity and abundance on locomotor behavior in larval zebrafish

Animal Microbiome, 3(1).

By: C. Weitekamp*, A. Kvasnicka*, S. Keely*, N. Brinkman*, X. Howey*, S. Gaballah*, D. Phelps*, T. Catron* ...

author keywords: Microbiome; Hyperactivity; Monoassociation; Gnotobiotic; Germ-free; Axenic; Zebrafish; Monocolonization
Source: ORCID
Added: May 8, 2021

2020 journal article

Derivation of stable embryonic stem cell-like, but transcriptionally heterogenous, induced pluripotent stem cells from non-permissive mouse strains

MAMMALIAN GENOME, 31(9-12), 263–286.

By: T. Garbutt n, K. Konganti*, T. Konneker n, A. Hillhouse*, D. Phelps n, A. Jones n, D. Aylor n, D. Threadgill*

MeSH headings : Animals; Biomarkers; Cell Differentiation; Cells, Cultured; Cellular Reprogramming / genetics; Embryonic Stem Cells / cytology; Embryonic Stem Cells / metabolism; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genetic Heterogeneity; Immunophenotyping; Induced Pluripotent Stem Cells / cytology; Induced Pluripotent Stem Cells / metabolism; Mice; Platelet Endothelial Cell Adhesion Molecule-1; Species Specificity; Transcriptome
Sources: Web Of Science, ORCID
Added: October 19, 2020

2020 journal article

In vivo assessment of respiratory burst inhibition by xenobiotic exposure using larval zebrafish

Journal of Immunotoxicology, 17(1), 94–104.

author keywords: Chemical screen; high throughput; phagocyte; reactive oxygen species (ROS); polycyclic aromatic hydrocarbons (PAH); endocrine disrupting compounds (EDC); lead
MeSH headings : Animals; Animals, Genetically Modified; Benzo(a)pyrene / adverse effects; Blood Cell Count; Cytotoxicity Tests, Immunologic / methods; Embryo, Nonmammalian; Estradiol / adverse effects; Feasibility Studies; High-Throughput Screening Assays / methods; Immunity, Innate / drug effects; Macrophages / drug effects; Macrophages / immunology; Methoxychlor / adverse effects; Neutrophils / drug effects; Neutrophils / immunology; Organometallic Compounds / adverse effects; Phenanthrenes / adverse effects; Reactive Oxygen Species / analysis; Reactive Oxygen Species / metabolism; Respiratory Burst / drug effects; Respiratory Burst / immunology; Zebrafish
Source: ORCID
Added: May 15, 2020

2019 journal article

Microbiota alter metabolism and mediate neurodevelopmental toxicity of 17β-estradiol

Scientific Reports, 9(1).

By: T. Catron*, A. Swank*, L. Wehmas*, D. Phelps*, S. Keely*, N. Brinkman*, J. McCord*, R. Singh* ...

MeSH headings : Animals; Embryonic Development / drug effects; Estradiol / metabolism; Estradiol / pharmacology; Estrogens / metabolism; Estrogens / pharmacology; Germ-Free Life / drug effects; Larva / drug effects; Larva / metabolism; Locomotion / drug effects; Microbiota / drug effects; Microbiota / genetics; Neurogenesis / drug effects; RNA, Ribosomal, 16S / genetics; Zebrafish / embryology; Zebrafish / metabolism; Zebrafish / microbiology
Sources: ORCID, Crossref
Added: September 23, 2019

2019 journal article

Triclosan-selected host-associated microbiota perform xenobiotic biotransformations in larval zebrafish

Toxicological Sciences.

author keywords: microbiome; microbiota; zebrafish; triclosan; triclosan sulfate; toxicokinetics; antimicrobial; antibacterial
Source: ORCID
Added: September 23, 2019

2018 journal article

Host developmental toxicity of BPA and BPA alternatives is inversely related to microbiota disruption in zebrafish

Toxicological Sciences, 10.

By: T. Catron*, S. Keely*, N. Brinkman*, T. Zurlinden*, C. Wood*, J. Wright*, D. Phelps*, E. Wheaton* ...

author keywords: microbiome; zebrafish; developmental toxicity; BPA
MeSH headings : Animals; Behavior, Animal / drug effects; Benzhydryl Compounds / chemistry; Benzhydryl Compounds / toxicity; Dose-Response Relationship, Drug; Environmental Pollutants / chemistry; Environmental Pollutants / toxicity; Larva / drug effects; Larva / microbiology; Microbiota / drug effects; Microbiota / genetics; Phenols / chemistry; Phenols / toxicity; RNA, Ribosomal, 16S; Structure-Activity Relationship; Zebrafish / growth & development; Zebrafish / microbiology
Source: ORCID
Added: September 23, 2019

2018 journal article

Permissiveness to form pluripotent stem cells may be an evolutionarily derived characteristic in Mus muscuius


By: T. Garbutt n, T. Konneker n, K. Konganti*, A. Hillhouse*, F. Swift-Haire n, A. Jones n, D. Phelps n, D. Aylor n, D. Threadgill*

MeSH headings : Animals; Cells, Cultured; Cellular Reprogramming / drug effects; Cellular Reprogramming / genetics; Culture Media / metabolism; Culture Media / pharmacology; Evolution, Molecular; Female; Fibroblasts; Glycogen Synthase Kinase 3 beta / antagonists & inhibitors; Glycogen Synthase Kinase 3 beta / metabolism; Induced Pluripotent Stem Cells; Leukemia Inhibitory Factor / metabolism; MAP Kinase Kinase Kinases / antagonists & inhibitors; MAP Kinase Kinase Kinases / metabolism; Male; Mice / genetics; Mice, Inbred Strains / genetics; Mouse Embryonic Stem Cells; Primary Cell Culture; Protein Kinase Inhibitors / pharmacology; Sex Factors; Transcription, Genetic
Sources: Web Of Science, ORCID
Added: October 16, 2018

2017 journal article

Development, and genetic and metabolic characterization of new tomato mutants with enhanced and deficient carotenoid content


By: Y. Dan*, G. Yousef n, F. Campbell*, D. Phelps*, C. Burnett*, A. Kekkonen*, A. Shockley*, M. Lila n

author keywords: Carotenoid; lycopene; -carotene; Solanum lycopersicum; mutagenesis
Sources: ORCID, Web Of Science
Added: August 6, 2018

2017 journal article

Microbial colonization is required for normal neurobehavioral development in zebrafish

Scientific Reports.

By: D. Phelps*, N. Brinkman*, S. Keely*, E. Anneken*, T. Catron*, D. Betancourt*, C. Wood*, S. Espenschied*, J. Rawls*, T. Tal*

MeSH headings : Aeromonas veronii / growth & development; Animals; Anti-Bacterial Agents / administration & dosage; Behavior, Animal; Embryo, Nonmammalian; Gastrointestinal Microbiome; Larva / growth & development; Larva / microbiology; Locomotion; Nervous System / growth & development; Vibrio cholerae / growth & development; Zebrafish / growth & development; Zebrafish / microbiology
Source: ORCID
Added: September 23, 2019


Updated: June 26th, 2023 10:31

2023 - present

East Carolina University Greenville, North Carolina, US
Postdoctoral Scholar Pharmacology and Toxicology

2022 - 2023

Food Packaging Forum Zurich, Zürich, CH
Independent Consultant

2022 - 2022

NC State University Raleigh, NC, US
Postdoctoral Research Scholar Molecular Biomedical Sciences

2017 - 2022

NC State University Raleigh, NC, US
Graduate Research Assistant Molecular Biomedical Sciences

2019 - 2019

Center for Environmental Health Durham, NC, US
Graduate Intern

2016 - 2017

ORISE Postbaccalaureate Fellow at US EPA

2015 - 2015

North Carolina State University Raleigh, NC, US
Undergraduate Research Assistant Prestage Department of Poultry Science

2014 - 2015

North Carolina State University Raleigh, NC, US
Undergraduate Research Assistant Program of Genetics

2011 - 2012

Institute for Sustainable and Renewable Resources Danville, VA, US
Undergraduate Research Assistant


Updated: June 8th, 2022 15:12

2017 - 2022

NC State University Raleigh, NC, US
PhD in Comparative Biomedical Sciences

2012 - 2015

North Carolina State University Raleigh, NC, US
Bachelor of Science in Microbiology with Minors in Biotechnology and French Language

2010 - 2012

Danville Community College Danville, VA, US
Associate of Arts and Sciences

Funding History

Funding history based on the linked ORCID record. Updated: December 18th, 2019 10:30

grant July 1, 2018 - July 1, 2020
NIH/NCSU Molecular Biology Training Program
National Institutes of Health