Drake Phelps
https://orcid.org/0000-0001-8350-5626
zebrafish, immunology, toxicology, immunotoxicology, PFAS
I'm an immunotoxicologist who is passionate about protecting human and environmental health from toxic threats, such as EDCs and PFAS.
Works (10)
Updated: July 5th, 2023 15:34
2023 journal article
Legacy and emerging per- and polyfluoroalkyl substances suppress the neutrophil respiratory burst
JOURNAL OF IMMUNOTOXICOLOGY, 20(1).
author keywords: Innate immunity; neutrophils; per- and polyfluoroalkyl substances (PFAS); reactive oxygen species; zebrafish
MeSH headings : Animals; Humans; Zebrafish; Neutrophils; Reactive Oxygen Species; Respiratory Burst; Fluorocarbons / toxicity; Alkanesulfonic Acids / toxicity; Environmental Pollutants
Sources: ORCID, Web Of Science
Added: February 15, 2023
2021 journal article
Monoassociation with bacterial isolates reveals the role of colonization, community complexity and abundance on locomotor behavior in larval zebrafish
Animal Microbiome, 3(1).
author keywords: Microbiome; Hyperactivity; Monoassociation; Gnotobiotic; Germ-free; Axenic; Zebrafish; Monocolonization
animalmicrobiome.biomedcentral.com (publisher PDF)
Source: ORCID
Added: May 8, 2021
2020 journal article
Derivation of stable embryonic stem cell-like, but transcriptionally heterogenous, induced pluripotent stem cells from non-permissive mouse strains
MAMMALIAN GENOME, 31(9-12), 263–286.
MeSH headings : Animals; Biomarkers; Cell Differentiation; Cells, Cultured; Cellular Reprogramming / genetics; Embryonic Stem Cells / cytology; Embryonic Stem Cells / metabolism; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genetic Heterogeneity; Immunophenotyping; Induced Pluripotent Stem Cells / cytology; Induced Pluripotent Stem Cells / metabolism; Mice; Platelet Endothelial Cell Adhesion Molecule-1; Species Specificity; Transcriptome
Sources: Web Of Science, ORCID
Added: October 19, 2020
2020 journal article
In vivo assessment of respiratory burst inhibition by xenobiotic exposure using larval zebrafish
Journal of Immunotoxicology, 17(1), 94–104.
author keywords: Chemical screen; high throughput; phagocyte; reactive oxygen species (ROS); polycyclic aromatic hydrocarbons (PAH); endocrine disrupting compounds (EDC); lead
MeSH headings : Animals; Animals, Genetically Modified; Benzo(a)pyrene / adverse effects; Blood Cell Count; Cytotoxicity Tests, Immunologic / methods; Embryo, Nonmammalian; Estradiol / adverse effects; Feasibility Studies; High-Throughput Screening Assays / methods; Immunity, Innate / drug effects; Macrophages / drug effects; Macrophages / immunology; Methoxychlor / adverse effects; Neutrophils / drug effects; Neutrophils / immunology; Organometallic Compounds / adverse effects; Phenanthrenes / adverse effects; Reactive Oxygen Species / analysis; Reactive Oxygen Species / metabolism; Respiratory Burst / drug effects; Respiratory Burst / immunology; Zebrafish
Source: ORCID
Added: May 15, 2020
2019 journal article
Microbiota alter metabolism and mediate neurodevelopmental toxicity of 17β-estradiol
Scientific Reports, 9(1).
MeSH headings : Animals; Embryonic Development / drug effects; Estradiol / metabolism; Estradiol / pharmacology; Estrogens / metabolism; Estrogens / pharmacology; Germ-Free Life / drug effects; Larva / drug effects; Larva / metabolism; Locomotion / drug effects; Microbiota / drug effects; Microbiota / genetics; Neurogenesis / drug effects; RNA, Ribosomal, 16S / genetics; Zebrafish / embryology; Zebrafish / metabolism; Zebrafish / microbiology
Sources: ORCID, Crossref
Added: September 23, 2019
2019 journal article
Triclosan-selected host-associated microbiota perform xenobiotic biotransformations in larval zebrafish
Toxicological Sciences.
author keywords: microbiome; microbiota; zebrafish; triclosan; triclosan sulfate; toxicokinetics; antimicrobial; antibacterial
Source: ORCID
Added: September 23, 2019
2018 journal article
Host developmental toxicity of BPA and BPA alternatives is inversely related to microbiota disruption in zebrafish
Toxicological Sciences, 10.
author keywords: microbiome; zebrafish; developmental toxicity; BPA
MeSH headings : Animals; Behavior, Animal / drug effects; Benzhydryl Compounds / chemistry; Benzhydryl Compounds / toxicity; Dose-Response Relationship, Drug; Environmental Pollutants / chemistry; Environmental Pollutants / toxicity; Larva / drug effects; Larva / microbiology; Microbiota / drug effects; Microbiota / genetics; Phenols / chemistry; Phenols / toxicity; RNA, Ribosomal, 16S; Structure-Activity Relationship; Zebrafish / growth & development; Zebrafish / microbiology
Source: ORCID
Added: September 23, 2019
2018 journal article
Permissiveness to form pluripotent stem cells may be an evolutionarily derived characteristic in Mus muscuius
SCIENTIFIC REPORTS, 8.
MeSH headings : Animals; Cells, Cultured; Cellular Reprogramming / drug effects; Cellular Reprogramming / genetics; Culture Media / metabolism; Culture Media / pharmacology; Evolution, Molecular; Female; Fibroblasts; Glycogen Synthase Kinase 3 beta / antagonists & inhibitors; Glycogen Synthase Kinase 3 beta / metabolism; Induced Pluripotent Stem Cells; Leukemia Inhibitory Factor / metabolism; MAP Kinase Kinase Kinases / antagonists & inhibitors; MAP Kinase Kinase Kinases / metabolism; Male; Mice / genetics; Mice, Inbred Strains / genetics; Mouse Embryonic Stem Cells; Primary Cell Culture; Protein Kinase Inhibitors / pharmacology; Sex Factors; Transcription, Genetic
Sources: Web Of Science, ORCID
Added: October 16, 2018
2017 journal article
Development, and genetic and metabolic characterization of new tomato mutants with enhanced and deficient carotenoid content
JOURNAL OF HORTICULTURAL SCIENCE & BIOTECHNOLOGY, 92(5), 475–483.
author keywords: Carotenoid; lycopene; -carotene; Solanum lycopersicum; mutagenesis
Sources: ORCID, Web Of Science
Added: August 6, 2018
2017 journal article
Microbial colonization is required for normal neurobehavioral development in zebrafish
Scientific Reports.
MeSH headings : Aeromonas veronii / growth & development; Animals; Anti-Bacterial Agents / administration & dosage; Behavior, Animal; Embryo, Nonmammalian; Gastrointestinal Microbiome; Larva / growth & development; Larva / microbiology; Locomotion; Nervous System / growth & development; Vibrio cholerae / growth & development; Zebrafish / growth & development; Zebrafish / microbiology
Source: ORCID
Added: September 23, 2019
Employment
Updated: June 26th, 2023 10:31
2023 - present
East Carolina University Greenville, North Carolina, US
Postdoctoral Scholar
Pharmacology and Toxicology
2022 - 2023
Food Packaging Forum Zurich, Zürich, CH
Independent Consultant
2022 - 2022
NC State University Raleigh, NC, US
Postdoctoral Research Scholar
Molecular Biomedical Sciences
2017 - 2022
NC State University Raleigh, NC, US
Graduate Research Assistant
Molecular Biomedical Sciences
2019 - 2019
Center for Environmental Health Durham, NC, US
Graduate Intern
2016 - 2017
ORISE/USEPA Durham, NC, US
ORISE Postbaccalaureate Fellow at US EPA
2015 - 2015
North Carolina State University Raleigh, NC, US
Undergraduate Research Assistant
Prestage Department of Poultry Science
2014 - 2015
North Carolina State University Raleigh, NC, US
Undergraduate Research Assistant
Program of Genetics
2011 - 2012
Institute for Sustainable and Renewable Resources Danville, VA, US
Undergraduate Research Assistant
Education
Updated: June 8th, 2022 15:12
2017 - 2022
NC State University Raleigh, NC, US
PhD in Comparative Biomedical Sciences
2012 - 2015
North Carolina State University Raleigh, NC, US
Bachelor of Science in Microbiology with Minors in Biotechnology and French Language
2010 - 2012
Danville Community College Danville, VA, US
Associate of Arts and Sciences
Funding History
Funding history based on the linked ORCID record. Updated: December 18th, 2019 10:30
grant
July 1, 2018 - July 1, 2020
NIH/NCSU Molecular Biology Training Program
National Institutes of Health
