Works (50)

Updated: July 26th, 2023 21:16

2023 journal article

Bulk and mosaic deletions of Egfr reveal regionally defined gliogenesis in the developing mouse forebrain

ISCIENCE, 26(3).

By: X. Zhang*, G. Xiao, C. Johnson*, Y. Cai, Z. Horowitz*, C. Mennicke, R. Coffey, M. Haider* ...

Sources: Web Of Science, ORCID
Added: June 5, 2023

2021 journal article

Epithelial-specific ERBB3 deletion results in a genetic background-dependent increase in intestinal and colon polyps that is mediated by EGFR

PLOS GENETICS, 17(11).

MeSH headings : Adenomatous Polyposis Coli Protein / genetics; Animals; Cell Proliferation / genetics; Colon / metabolism; Colon / pathology; Colonic Polyps / genetics; Colonic Polyps / pathology; Colonic Polyps / therapy; Colorectal Neoplasms / genetics; Colorectal Neoplasms / pathology; Colorectal Neoplasms / therapy; Disease Models, Animal; ErbB Receptors / genetics; Gene Expression Regulation, Neoplastic / genetics; Gene Silencing; Humans; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Intestinal Polyps / genetics; Intestinal Polyps / pathology; Intestinal Polyps / therapy; Mice; Receptor, ErbB-3 / antagonists & inhibitors; Receptor, ErbB-3 / genetics
Source: Web Of Science
Added: December 13, 2021

2020 journal article

Derivation of stable embryonic stem cell-like, but transcriptionally heterogenous, induced pluripotent stem cells from non-permissive mouse strains

MAMMALIAN GENOME, 31(9-12), 263–286.

By: T. Garbutt n, K. Konganti*, T. Konneker n, A. Hillhouse*, D. Phelps n, A. Jones n, D. Aylor n, D. Threadgill*

MeSH headings : Animals; Biomarkers; Cell Differentiation; Cells, Cultured; Cellular Reprogramming / genetics; Embryonic Stem Cells / cytology; Embryonic Stem Cells / metabolism; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genetic Heterogeneity; Immunophenotyping; Induced Pluripotent Stem Cells / cytology; Induced Pluripotent Stem Cells / metabolism; Mice; Platelet Endothelial Cell Adhesion Molecule-1; Species Specificity; Transcriptome
Sources: Web Of Science, ORCID
Added: October 19, 2020

2019 journal article

Locally Fixed Alleles: A method to localize gene drive to island populations

SCIENTIFIC REPORTS, 9.

By: J. Sudweeks n, B. Hollingsworth n, D. Blondel n, K. Campbell, S. Dhole n, J. Eisemann*, O. Edwards*, J. Godwin n ...

MeSH headings : Alleles; Animals; Biodiversity; Islands
Sources: Web Of Science, ORCID
Added: November 18, 2019

2019 journal article

Population-Based Analysis of DNA Damage and Epigenetic Effects of 1,3-Butadiene in the Mouse

CHEMICAL RESEARCH IN TOXICOLOGY, 32(5), 887–898.

By: L. Lewis*, B. Borowa-Mazgaj*, A. Conti*, G. Chappell*, Y. Luo*, W. Bodnar*, K. Konganti*, F. Wright n ...

MeSH headings : Animals; Butadienes / toxicity; Carcinogens, Environmental / toxicity; DNA Adducts / chemistry; DNA Adducts / genetics; DNA Adducts / metabolism; DNA Methylation / drug effects; Epigenesis, Genetic / drug effects; Guanine / analogs & derivatives; Guanine / chemistry; Histones / metabolism; Kidney / drug effects; Liver / drug effects; Lung / drug effects; Male; Mice; Mutagens / toxicity
Source: Web Of Science
Added: June 17, 2019

2019 journal article

Using Collaborative Cross Mouse Population to Fill Data Gaps in Risk Assessment: A Case Study of Population-Based Analysis of Toxicokinetics and Kidney Toxicodynamics of Tetrachloroethylene

ENVIRONMENTAL HEALTH PERSPECTIVES, 127(6).

By: Y. Luo*, J. Cichocki*, N. Hsieh*, L. Lewis*, F. Wright n, D. Threadgill*, W. Chiu*, I. Rusyn*

MeSH headings : Animals; Collaborative Cross Mice; Glutathione / analogs & derivatives; Glutathione / metabolism; Hepatitis A Virus Cellular Receptor 1 / genetics; Hepatitis A Virus Cellular Receptor 1 / metabolism; Kidney / drug effects; Kidney Diseases / chemically induced; Kidney Diseases / metabolism; Liver / drug effects; Male; Risk Assessment / methods; Species Specificity; Tetrachloroethylene / metabolism; Tetrachloroethylene / pharmacokinetics; Tetrachloroethylene / toxicity; Toxicokinetics
Source: Web Of Science
Added: July 29, 2019

2018 journal article

Permissiveness to form pluripotent stem cells may be an evolutionarily derived characteristic in Mus muscuius

SCIENTIFIC REPORTS, 8.

By: T. Garbutt n, T. Konneker n, K. Konganti*, A. Hillhouse*, F. Swift-Haire n, A. Jones n, D. Phelps n, D. Aylor n, D. Threadgill*

MeSH headings : Animals; Cells, Cultured; Cellular Reprogramming / drug effects; Cellular Reprogramming / genetics; Culture Media / metabolism; Culture Media / pharmacology; Evolution, Molecular; Female; Fibroblasts; Glycogen Synthase Kinase 3 beta / antagonists & inhibitors; Glycogen Synthase Kinase 3 beta / metabolism; Induced Pluripotent Stem Cells; Leukemia Inhibitory Factor / metabolism; MAP Kinase Kinase Kinases / antagonists & inhibitors; MAP Kinase Kinase Kinases / metabolism; Male; Mice / genetics; Mice, Inbred Strains / genetics; Mouse Embryonic Stem Cells; Primary Cell Culture; Protein Kinase Inhibitors / pharmacology; Sex Factors; Transcription, Genetic
Sources: Web Of Science, ORCID
Added: October 16, 2018

2015 journal article

Sensitivity to hepatotoxicity due to epigallocatechin gallate is affected by genetic background in diversity outbred mice

FOOD AND CHEMICAL TOXICOLOGY, 76, 19–26.

By: R. Church*, D. Gatti*, T. Urban*, N. Long*, . Yang*, Q. Shi*, J. Eaddy*, M. Mosedale* ...

author keywords: Green tea; Epigallocatechin gallate; Hepatotoxicity; Population variability; Herbal; Diversity outbred
MeSH headings : Animals; Antioxidants / administration & dosage; Antioxidants / adverse effects; Catechin / administration & dosage; Catechin / adverse effects; Catechin / analogs & derivatives; Chemical and Drug Induced Liver Injury / genetics; Chromosome Mapping; Dose-Response Relationship, Drug; Genotyping Techniques; In Situ Nick-End Labeling; Liver / drug effects; Liver / metabolism; Male; Mice / genetics; Phenotype; Polymorphism, Single Nucleotide; Polyphenols / administration & dosage; Polyphenols / adverse effects; Quantitative Trait Loci; Tea / chemistry
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Epidermal growth factor receptor plays a role in the regulation of liver and plasma lipid levels in adult male mice

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 306(5), G370–G381.

By: L. Scheving*, X. Zhang*, O. Garcia*, R. Wang*, M. Stevenson*, D. Threadgill n, W. Russell*

author keywords: liver; epidermal growth factor; Dsk5; cholesterol; hepatomegaly; low-density lipoprotein receptor
MeSH headings : Adipose Tissue / anatomy & histology; Alleles; Animals; Chondroitin Sulfates; Dermatan Sulfate; ErbB Receptors / genetics; ErbB Receptors / metabolism; Female; Gene Expression Regulation, Developmental / physiology; Heparitin Sulfate; Kidney / anatomy & histology; Lipid Metabolism / physiology; Lipids / blood; Liver / anatomy & histology; Liver / metabolism; Male; Mice; Sarcoma, Small Cell; Signal Transduction; Spleen / anatomy & histology; Testis / anatomy & histology
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Identification and Characterization of an Invasion Antigen B Gene from the Oral Pathogen Campylobacter rectus

INDIAN JOURNAL OF MICROBIOLOGY, 54(1), 33–40.

By: M. LaGier* & D. Threadgill n

author keywords: Campylobacter rectus; Periodontitis; Invasion antigen B; Virulence factor
Source: Web Of Science
Added: August 6, 2018

2014 article

Status and access to the Collaborative Cross population (vol 23, pg 706, 2012)

Welsh, C. E., Miller, D. R., Manly, K. F., Wang, J., McMillan, L., Morahan, G., … Villena, F. P.-M. (2014, April). MAMMALIAN GENOME, Vol. 25, pp. 192–192.

By: C. Welsh*, D. Miller*, K. Manly*, J. Wang*, L. McMillan*, G. Morahan*, R. Mott*, F. Iraqi*, D. Threadgill n, F. Villena*

Source: Web Of Science
Added: August 6, 2018

2013 journal article

Conditional Inactivation of TNF alpha-Converting Enzyme in Chondrocytes Results in an Elongated Growth Plate and Shorter Long Bones

PLOS ONE, 8(1).

By: K. Saito*, K. Horiuchi*, T. Kimura*, S. Mizuno*, M. Yoda*, H. Morioka*, H. Akiyama*, D. Threadgill n ...

MeSH headings : ADAM Proteins / genetics; ADAM Proteins / metabolism; ADAM17 Protein; Animals; Bone Development / genetics; Cell Differentiation; Chondrocytes / metabolism; Chondrocytes / physiology; Collagen Type II / genetics; Embryonic Development / genetics; ErbB Receptors / genetics; ErbB Receptors / metabolism; Gene Expression Regulation, Developmental; Growth Plate / growth & development; Growth Plate / metabolism; Male; Matrix Metalloproteinase 13 / metabolism; Mice; Mutation; Osteoprotegerin / metabolism; RANK Ligand / metabolism; Signal Transduction; Tumor Necrosis Factor-alpha / metabolism
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Identification of a Novel Polymorphism in X-Linked Sterol-4-Alpha-Carboxylate 3-Dehydrogenase (Nsdhl) Associated with Reduced High-Density Lipoprotein Cholesterol Levels in I/LnJ Mice

G3-GENES GENOMES GENETICS, 3(10), 1819–1825.

By: D. Bautz n, K. Broman* & D. Threadgill n

author keywords: QTL; genomics; HDL cholesterol; Nsdhl
MeSH headings : 3-Hydroxysteroid Dehydrogenases / genetics; Animals; Animals, Inbred Strains; Apolipoprotein A-II / genetics; Cholesterol, HDL / blood; Cholesterol, HDL / genetics; Genetic Linkage; Lipid Metabolism / genetics; Mice; Polymorphism, Single Nucleotide; Quantitative Trait Loci; X Chromosome / genetics
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Modeling Host Genetic Regulation of Influenza Pathogenesis in the Collaborative Cross

PLOS PATHOGENS, 9(2).

By: M. Ferris*, D. Aylor*, D. Bottomly*, A. Whitmore*, L. Aicher*, T. Bell*, B. Bradel-Tretheway*, J. Bryan* ...

MeSH headings : Animals; Crosses, Genetic; Female; Genetic Variation; Host-Pathogen Interactions / genetics; Humans; Influenza A virus; Influenza, Human / genetics; Influenza, Human / pathology; Influenza, Human / virology; Lung / pathology; Mice; Mice, Inbred Strains; Models, Genetic; Orthomyxoviridae Infections / genetics; Orthomyxoviridae Infections / pathology; Orthomyxoviridae Infections / virology; Phenotype; Reassortant Viruses / genetics; Reassortant Viruses / pathogenicity; Recombination, Genetic; Rodent Diseases / genetics; Rodent Diseases / pathology; Rodent Diseases / virology; Species Specificity; Virus Replication
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Pleiotropic Effects of the Trichloroethylene-Associated P81S VHL Mutation on Metabolism, Apoptosis, and ATM-Mediated DNA Damage Response

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 105(18), 1355–1364.

By: M. DeSimone n, W. Rathmell n & D. Threadgill n

MeSH headings : Animals; Apoptosis; Arginine; Ataxia Telangiectasia Mutated Proteins; Carcinoma, Renal Cell / genetics; Carcinoma, Renal Cell / metabolism; Cell Cycle Proteins / metabolism; DNA Damage; DNA-Binding Proteins / metabolism; Embryonic Stem Cells; Glutamine; Humans; Hypoxia-Inducible Factor 1 / metabolism; Immunohistochemistry; Kidney Neoplasms / genetics; Kidney Neoplasms / metabolism; Mice; Occupational Exposure; Point Mutation; Proline; Protein Array Analysis; Protein Serine-Threonine Kinases / metabolism; Serine; Teratoma / genetics; Trichloroethylene / toxicity; Tumor Suppressor Proteins / metabolism; Ubiquitin-Protein Ligases / metabolism; Von Hippel-Lindau Tumor Suppressor Protein / genetics
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Tumor fibroblast-derived epiregulin promotes growth of colitis-associated neoplasms through ERK

JOURNAL OF CLINICAL INVESTIGATION, 123(4), 1428–1443.

By: C. Neufert*, C. Becker, O. Tuereci, M. Waldner, I. Backert, K. Floh, I. Atreya, M. Leppkes ...

MeSH headings : Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colitis / chemically induced; Colitis / complications; Colon / pathology; Colorectal Neoplasms / etiology; Colorectal Neoplasms / pathology; Epidermal Growth Factor / genetics; Epidermal Growth Factor / metabolism; Epidermal Growth Factor / physiology; Epiregulin; Extracellular Signal-Regulated MAP Kinases / metabolism; Fibroblasts / metabolism; Fibroblasts / pathology; Fibroblasts / transplantation; Humans; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Ki-67 Antigen / metabolism; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Transcriptome; Tumor Burden
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Using the emerging Collaborative Cross to probe the immune system

Genes & Immunity, 15(1), 38–46.

By: J. Phillippi*, Y. Xie*, D. Miller*, T. Bell*, Z. Zhang*, A. Lenarcic*, D. Aylor*, S. Krovi* ...

author keywords: Collaborative Cross; Fc epsilon R; QTL
MeSH headings : Animals; B-Lymphocytes / physiology; CD11c Antigen / metabolism; CD8-Positive T-Lymphocytes / physiology; Genetic Variation; Genome-Wide Association Study; Haplotypes; Immunogenetics / methods; Lymphocyte Subsets / physiology; Mice; Mice, Inbred Strains / genetics; Mice, Inbred Strains / immunology; Quantitative Trait Loci; Receptors, IgE / metabolism; T-Lymphocytes / physiology
Sources: Web Of Science, Crossref
Added: August 6, 2018

2012 journal article

Both stromal cell and colonocyte epidermal growth factor receptors control HCT116 colon cancer cell growth in tumor xenografts

CARCINOGENESIS, 33(10), 1930–1939.

By: R. Mustafi, U. Dougherty, H. Shah, H. Dehghan, A. Gliksberg, J. Wu, H. Zhu, L. Joseph ...

MeSH headings : Animals; Apoptosis; Cell Transformation, Neoplastic; Coculture Techniques; Colonic Neoplasms / metabolism; Colonic Neoplasms / pathology; ErbB Receptors / metabolism; HCT116 Cells; Humans; Interleukin-1beta / metabolism; Mice; Stromal Cells / metabolism; Transfection; Transplantation, Heterologous
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Dietary calcium supplementation enhances efficacy but also toxicity of EGFR inhibitor therapy for colon cancer

CANCER BIOLOGY & THERAPY, 13(3), 130–137.

By: E. Rinella*, E. Bankaitis* & D. Threadgill n

author keywords: colon cancer; EGFR; calcium; mouse models; AG1478; therapy; toxicity
MeSH headings : Animals; Antineoplastic Agents / pharmacology; Antineoplastic Agents / therapeutic use; Antineoplastic Agents / toxicity; Azoxymethane; Calcium / pharmacology; Calcium / therapeutic use; Calcium / toxicity; Cell Line, Tumor; Cell Proliferation / drug effects; Cell Survival / drug effects; Colonic Neoplasms / chemically induced; Colonic Neoplasms / drug therapy; Colonic Neoplasms / pathology; Dietary Supplements; Drug Screening Assays, Antitumor; Drug Synergism; ErbB Receptors / antagonists & inhibitors; Female; Humans; MAP Kinase Signaling System / drug effects; Male; Mice; Mice, Inbred C57BL; Quinazolines / pharmacology; Quinazolines / therapeutic use; Quinazolines / toxicity; Random Allocation; Tumor Burden / drug effects; Tyrphostins / pharmacology; Tyrphostins / therapeutic use; Tyrphostins / toxicity
Source: Web Of Science
Added: August 6, 2018

2012 journal article

EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis

CANCER CELL, 22(3), 304–317.

By: C. Ardito*, B. Gruener, K. Takeuchi*, C. Lubeseder-Martellato*, N. Teichmann*, P. Mazur*, K. DelGiorno*, E. Carpenter* ...

MeSH headings : ADAM Proteins / genetics; ADAM Proteins / metabolism; ADAM17 Protein; Animals; Carcinoma, Pancreatic Ductal / genetics; Carcinoma, Pancreatic Ductal / metabolism; Carcinoma, Pancreatic Ductal / pathology; Cell Line, Tumor; Cell Transformation, Neoplastic; Epithelial Cells; ErbB Receptors / biosynthesis; ErbB Receptors / genetics; ErbB Receptors / metabolism; Extracellular Signal-Regulated MAP Kinases / metabolism; Genes, ras; Humans; Mice; Mice, Transgenic; Pancreas / metabolism; Pancreas / pathology; Pancreatic Neoplasms / genetics; Pancreatic Neoplasms / metabolism; Pancreatic Neoplasms / pathology; Proto-Oncogene Proteins p21(ras) / biosynthesis; Proto-Oncogene Proteins p21(ras) / genetics; Proto-Oncogene Proteins p21(ras) / metabolism
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Efficacy of EGFR Inhibition Is Modulated by Model, Sex, Genetic Background and Diet: Implications for Preclinical Cancer Prevention and Therapy Trials

PLOS ONE, 7(6).

By: E. Rinella* & D. Threadgill n

MeSH headings : Animals; Antineoplastic Agents / pharmacology; Antineoplastic Agents / therapeutic use; Azoxymethane / toxicity; Colorectal Neoplasms / chemically induced; Colorectal Neoplasms / drug therapy; Colorectal Neoplasms / genetics; Diet; Disease Models, Animal; ErbB Receptors / antagonists & inhibitors; ErbB Receptors / metabolism; Female; Male; Mice; Mice, Inbred C57BL; Phosphorylation; Quinazolines / pharmacology; Quinazolines / therapeutic use; Sex Factors; Tyrphostins / pharmacology; Tyrphostins / therapeutic use
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation

JOURNAL OF EXPERIMENTAL MEDICINE, 209(6), 1105–1119.

By: C. Franzke*, C. Cobzaru*, A. Triantafyllopoulou*, S. Loeffek, K. Horiuchi*, D. Threadgill n, T. Kurz, N. Rooijen*, L. Bruckner-Tuderman*, C. Blobel*

MeSH headings : ADAM Proteins / genetics; ADAM Proteins / metabolism; ADAM17 Protein; Administration, Topical; Animals; Animals, Newborn; Cell Differentiation / physiology; Dermatitis, Atopic / pathology; Epidermal Cells; Epidermis / metabolism; Epidermis / pathology; ErbB Receptors / genetics; ErbB Receptors / metabolism; Gene Expression Regulation, Developmental; Interleukin-1 / metabolism; Keratinocytes / cytology; Keratinocytes / metabolism; Macrophages / pathology; Mice; Mice, Mutant Strains; Skin / cytology; Skin / growth & development; Skin / metabolism; Transforming Growth Factor alpha / administration & dosage; Transforming Growth Factor alpha / genetics; Transforming Growth Factor alpha / pharmacology; Transglutaminases / metabolism
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Expression quantitative trait loci for extreme host response to influenza a in pre-collaborative cross mice

G3-Genes Genomes Genetics, 2(2), 213–221.

By: D. Bottomly, M. Ferris, L. Aicher, E. Rosenzweig, A. Whitmore, D. Aylor, B. Haagmans, L. Gralinski ...

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Genetic Analysis of Hematological Parameters in Incipient Lines of the Collaborative Cross

G3-GENES GENOMES GENETICS, 2(2), 157–165.

By: S. Kelada*, D. Aylor*, B. Peck*, J. Ryan*, U. Tavarez*, R. Buus*, D. Miller*, E. Chesler* ...

author keywords: Mouse Genetic Resource; Mouse Collaborative Cross hematology hemoglobin beta mean red cell volume; QTL mouse genetics complex traits shared ancestry
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Genome-wide association mapping of loci for antipsychotic-induced extrapyramidal symptoms in mice

MAMMALIAN GENOME, 23(5-6), 322–335.

By: J. Crowley*, Y. Kim*, J. Szatkiewicz*, A. Pratt*, C. Quackenbush*, D. Adkins*, E. Oord*, M. Bogue* ...

MeSH headings : Animals; Antipsychotic Agents / adverse effects; Basal Ganglia Diseases / chemically induced; Basal Ganglia Diseases / genetics; Basal Ganglia Diseases / physiopathology; Chromosome Mapping; Dyskinesia, Drug-Induced / genetics; Dyskinesia, Drug-Induced / physiopathology; Female; Genome-Wide Association Study; Humans; Male; Mice; Mice, Inbred A; Motor Activity; Polymorphism, Single Nucleotide
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Mapping Six New Susceptibility to Colon Cancer (Scc) Loci Using a Mouse Interspecific Backcross

G3-GENES GENOMES GENETICS, 2(12), 1577–1584.

By: C. Eversley*, X. Yuying, R. Pearsall* & D. Threadgill n

author keywords: spretus; cancer modifier; colorectal cancer
MeSH headings : Alleles; Animals; Chromosome Mapping; Chromosomes / genetics; Colonic Neoplasms / genetics; Colonic Neoplasms / metabolism; Crosses, Genetic; Genetic Predisposition to Disease; Genome; Genotype; Mice; Phenotype; Quantitative Trait Loci
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Status and access to the Collaborative Cross population

MAMMALIAN GENOME, 23(9-10), 706–712.

By: C. Welsh*, D. Miller*, K. Manly*, J. Wang*, L. McMillan*, G. Morahan*, R. Mott*, F. Iraqi*, D. Threadgill n, F. Villena*

MeSH headings : Animals; Cooperative Behavior; Genome; Internet; Male; Mice; Mice, Inbred Strains / genetics
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Ten Years of the Collaborative Cross

G3-GENES GENOMES GENETICS, 2(2), 153–156.

By: D. Threadgill n & G. Churchill*

Source: Web Of Science
Added: August 6, 2018

2011 journal article

Architecture of energy balance traits in emerging lines of the Collaborative Cross

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 300(6), E1124–E1134.

By: W. Mathes*, D. Aylor*, D. Miller*, G. Churchill*, E. Chesler*, F. Villena*, D. Threadgill n, D. Pomp*

author keywords: genetics; wheel running; adiposity; body weight; quantitative trait loci
MeSH headings : Alleles; Analysis of Variance; Animals; Body Fat Distribution; Body Weight / genetics; Body Weight / physiology; Chromosome Mapping; Chromosomes / genetics; Crosses, Genetic; Eating / genetics; Eating / physiology; Energy Metabolism / genetics; Energy Metabolism / physiology; Genotype; Linkage Disequilibrium; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Motor Activity / physiology; Phenotype; Physical Conditioning, Animal / physiology; Quantitative Trait Loci; Running / physiology; Sample Size
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis

Nature Medicine, 17(10), 1242–1272.

By: G. Bollee, M. Flamant, S. Schordan, C. Fligny, E. Rumpel, M. Milon, E. Schordan, N. Sabaa ...

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Epiregulin-dependent amphiregulin expression and ERBB2 signaling are involved in luteinizing hormone-induced paracrine signaling pathways in mouse ovary

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 405(2), 319–324.

By: K. Kim*, H. Lee*, D. Threadgill n & D. Lee*

author keywords: Amphiregulin; Epiregulin; EGFR and ERBB2 phosphorylation; Oocyte maturation; Ovulation
MeSH headings : Amphiregulin; Animals; EGF Family of Proteins; Epidermal Growth Factor / genetics; Epidermal Growth Factor / metabolism; Epiregulin; ErbB Receptors / metabolism; Female; Glycoproteins / biosynthesis; Glycoproteins / genetics; Intercellular Signaling Peptides and Proteins / biosynthesis; Intercellular Signaling Peptides and Proteins / genetics; Luteinizing Hormone / metabolism; Meiosis; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Ovary / cytology; Ovary / metabolism; Ovary / physiology; Ovulation; Phosphorylation; RNA, Messenger / biosynthesis; Receptor, ErbB-2 / metabolism; Signal Transduction
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Genetic analysis of complex traits in the emerging Collaborative Cross

GENOME RESEARCH, 21(8), 1213–1222.

By: D. Aylor, W. Valdar, W. Foulds-Mathes, R. Buus, R. Verdugo, R. Baric, M. Ferris, J. Frelinger ...

MeSH headings : Animals; Crosses, Genetic; Female; Gene Expression; Genetic Association Studies; Genome; Haplotypes; Male; Mice; Phenotype; Quantitative Trait Loci
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Interstrain Differences in the Liver Effects of Trichloroethylene in a Multistrain Panel of Inbred Mice

TOXICOLOGICAL SCIENCES, 120(1), 206–217.

By: B. Bradford, E. Lock, O. Kosyk, S. Kim, T. Uehara, D. Harbourt*, M. DeSimone*, D. Threadgill n ...

author keywords: trichloroethylene; metabolism; genetics; peroxisome proliferator-activated receptor alpha; acute exposure; gene expression
MeSH headings : Animals; Environmental Pollutants / blood; Environmental Pollutants / metabolism; Environmental Pollutants / toxicity; Gene Expression / drug effects; Gene Expression Profiling; Liver / drug effects; Liver / metabolism; Liver / pathology; Male; Mice; Mice, Inbred Strains; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; Species Specificity; Trichloroethylene / blood; Trichloroethylene / metabolism; Trichloroethylene / toxicity
Source: Web Of Science
Added: August 6, 2018

2011 journal article

MicroRNA expression in the livers of inbred mice

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 714(1-2), 126–133.

author keywords: MicroRNA; Liver; Mouse; Gene expression
MeSH headings : Animals; Gene Expression; Liver / metabolism; Mice; Mice, Inbred Strains / genetics; MicroRNAs / metabolism; Polymorphism, Single Nucleotide
Sources: Web Of Science, Crossref
Added: August 6, 2018

2011 journal article

The Collaborative Cross: A Recombinant Inbred Mouse Population for the Systems Genetic Era

ILAR JOURNAL, 52(1), 24–31.

By: D. Threadgill*, D. Miller, G. Churchill & F. Villena

author keywords: aging; Collaborative Cross (CC); mouse model; recombinant inbred mice; systems genetics; genetic reference population
MeSH headings : Aging / genetics; Aging / physiology; Animals; Crosses, Genetic; Mice; Models, Animal
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Genetic mapping and developmental timing of transmission ratio distortion in a mouse interspecific backcross

BMC GENETICS, 11.

By: C. Eversley*, T. Clark*, Y. Xie*, J. Steigerwalt n, T. Bell*, F. Villena*, D. Threadgill n

MeSH headings : Alleles; Animals; Chromosome Mapping; Female; Genotype; Hybridization, Genetic; Inheritance Patterns; Male; Mice / genetics; Mice, Inbred A; Microsatellite Repeats; Models, Genetic
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Maternal Dioxin Exposure Combined with a Diet High in Fat Increases Mammary Cancer Incidence in Mice

ENVIRONMENTAL HEALTH PERSPECTIVES, 118(5), 596–601.

By: M. La Merrill*, R. Harper*, L. Birnbaum*, R. Cardiff* & D. Threadgill n

author keywords: COMT; CYP1B1; dioxin; high-fat diet; mammary cancer; puberty
MeSH headings : Animals; Aryl Hydrocarbon Hydroxylases / genetics; Catechol O-Methyltransferase / genetics; Cocarcinogenesis; Cytochrome P-450 CYP1B1; Dietary Fats / administration & dosage; Dietary Fats / adverse effects; Environmental Pollutants / administration & dosage; Environmental Pollutants / toxicity; Estrogens, Non-Steroidal / administration & dosage; Estrogens, Non-Steroidal / toxicity; Female; Gene Expression / drug effects; Humans; Mammary Neoplasms, Experimental / etiology; Mammary Neoplasms, Experimental / genetics; Mammary Neoplasms, Experimental / pathology; Mice; Polychlorinated Dibenzodioxins / administration & dosage; Polychlorinated Dibenzodioxins / toxicity; Pregnancy; Prenatal Exposure Delayed Effects / etiology; Risk Factors
Source: Web Of Science
Added: August 6, 2018

2010 article

Toxicogenetics: population-based testing of drug and chemical safety in mouse models (vol 11, pg 1127, 2010)

Rusyn, I., Gatti, D. M., Wiltshire, T., Kleeberger, S. R., & Threadgill, D. W. (2010, September). PHARMACOGENOMICS, Vol. 11, pp. 1344–1344.

By: I. Rusyn, D. Gatti*, T. Wiltshire, S. Kleeberger* & D. Threadgill n

MeSH headings : Animals; Disease Models, Animal; Drug Evaluation, Preclinical / methods; Drug-Related Side Effects and Adverse Reactions / genetics; Humans; Mice; Quantitative Trait Loci / genetics; Species Specificity; Toxicogenetics / methods
Source: Web Of Science
Added: August 6, 2018

2009 article

Animal models of autism spectrum disorders: Information for neurotoxicologists

Halladay, A. K., Amaral, D., Aschner, M., Bolivar, V. J., Bowman, A., DiCicco-Bloom, E., … Threadgill, D. W. (2009, September). NEUROTOXICOLOGY, Vol. 30, pp. 811–821.

By: A. Halladay, D. Amaral, M. Aschner, V. Bolivar, A. Bowman, E. DiCicco-Bloom, S. Hyman, F. Keller ...

author keywords: Animal models; Autism; Neurotoxicology; Symposium
MeSH headings : Animals; Child; Child Development Disorders, Pervasive / chemically induced; Child Development Disorders, Pervasive / genetics; Child Development Disorders, Pervasive / physiopathology; Child, Preschool; Disease Models, Animal; Drosophila melanogaster; Environment; Genetic Predisposition to Disease; Humans; Mice; Neurotoxicity Syndromes / complications; Toxicology
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Dietary Fat Alters Body Composition, Mammary Development, and Cytochrome P450 Induction after Maternal TCDD Exposure in DBA/2J Mice with Low-Responsive Aryl Hydrocarbon Receptors

ENVIRONMENTAL HEALTH PERSPECTIVES, 117(9), 1414–1419.

By: M. La Merrill*, B. Kuruvilla*, D. Pomp*, L. Birnbaum* & D. Threadgill n

author keywords: aryl hydrocarbon receptor; fetal loss; gene-environment interactions; mouse; obesity; 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
MeSH headings : Animals; Body Composition; Cytochrome P-450 Enzyme System / biosynthesis; Dietary Fats / administration & dosage; Enzyme Induction; Female; Mammary Glands, Animal / growth & development; Mammary Glands, Animal / metabolism; Maternal Exposure; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Polychlorinated Dibenzodioxins / toxicity; Pregnancy; Receptors, Aryl Hydrocarbon / metabolism
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Elucidation of the transcription network governing mammalian sex determination by exploiting strain-specific susceptibility to sex reversal

GENES & DEVELOPMENT, 23(21), 2521–2536.

By: S. Munger, D. Aylor, H. Syed, P. Magwene, D. Threadgill* & B. Capel

author keywords: Sex determination; genetical genomics; systems genetics; eQTL; transcription networks; organogenesis
MeSH headings : Animals; Breeding; Cluster Analysis; Disorders of Sex Development; Female; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genetic Variation; Gonads / metabolism; Male; Mice; Mice, Inbred C57BL; Quantitative Trait Loci / genetics; SOX9 Transcription Factor / metabolism; Sex Determination Processes; X Chromosome / genetics; Y Chromosome / genetics
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Epidermal Growth Factor Receptor Is Required for Colonic Tumor Promotion by Dietary Fat in the Azoxymethane/Dextran Sulfate Sodium Model: Roles of Transforming Growth Factor-alpha and PTGS2

CLINICAL CANCER RESEARCH, 15(22), 6780–6789.

By: U. Dougherty n, D. Cerasi n, I. Taylor n, M. Kocherginsky n, U. Tekin n, S. Badal n, L. Aluri n, A. Sehdev n ...

MeSH headings : Animals; Azoxymethane / pharmacology; Blood Glucose / metabolism; Colonic Neoplasms / metabolism; Cyclooxygenase 2 / metabolism; Dextran Sulfate / pharmacology; ErbB Receptors / metabolism; Gene Expression Regulation, Neoplastic; Insulin / blood; Insulin Resistance; Ligands; Mice; Mice, Inbred C57BL; Point Mutation; Transforming Growth Factor alpha / metabolism
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans

GENOME RESEARCH, 19(9), 1507–1515.

By: A. Harrill, P. Watkins*, S. Su, P. Ross, D. Harbourt, I. Stylianou, G. Boorman*, M. Russo ...

MeSH headings : Acetaminophen / administration & dosage; Acetaminophen / adverse effects; Alanine Transaminase / blood; Animals; Chemical and Drug Induced Liver Injury / genetics; Chemical and Drug Induced Liver Injury / physiopathology; Cohort Studies; Genetic Predisposition to Disease; Humans; Hyaluronan Receptors / chemistry; Hyaluronan Receptors / genetics; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Polymorphism, Genetic; Sequence Analysis, DNA / methods; Species Specificity
Source: Web Of Science
Added: August 6, 2018

2009 review

Murine models of colorectal cancer

[Review of ]. MAMMALIAN GENOME, 20(5), 261–268.

By: J. Uronis* & D. Threadgill n

MeSH headings : Animals; Colorectal Neoplasms / genetics; Colorectal Neoplasms / metabolism; Colorectal Neoplasms / pathology; Disease Models, Animal; Humans; Mice; Mice, Inbred Strains; Proto-Oncogene Proteins c-myc / genetics; Proto-Oncogene Proteins c-myc / metabolism; Signal Transduction
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Placental and Embryonic Growth Restriction in Mice With Reduced Function Epidermal Growth Factor Receptor Alleles

GENETICS, 183(1), 207–218.

By: J. Dackor, K. Caron* & D. Threadgill n

MeSH headings : Alleles; Animals; Animals, Newborn; Embryo, Mammalian; Female; Fetal Growth Retardation / genetics; Fetal Growth Retardation / mortality; Fetal Growth Retardation / pathology; Genes, erbB-1 / physiology; Homozygote; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Transgenic; Organ Size / genetics; Placenta / pathology; Placenta Diseases / genetics; Placenta Diseases / mortality; Placenta Diseases / pathology; Placentation; Pregnancy; Species Specificity
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Placental overgrowth and fertility defects in mice with a hypermorphic allele of epidermal growth factor receptor

MAMMALIAN GENOME, 20(6), 339–349.

By: J. Dackor*, M. Li* & D. Threadgill n

MeSH headings : Alleles; Animals; ErbB Receptors / genetics; ErbB Receptors / metabolism; Female; Fertility; Gene Expression; Male; Mice / genetics; Mice / growth & development; Mice / physiology; Mice, Inbred Strains; Mice, Transgenic; Ovary / physiology; Placenta / metabolism; Placentation; Signal Transduction; Uterus / growth & development; Uterus / physiology
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Population-Based Discovery of Toxicogenomics Biomarkers for Hepatotoxicity Using a Laboratory Strain Diversity Panel

TOXICOLOGICAL SCIENCES, 110(1), 235–243.

By: A. Harrill, P. Ross, D. Gatti, D. Threadgill* & I. Rusyn

author keywords: biomarkers; toxicogenomics; acetaminophen; microarray; liver; phenotypic anchoring
MeSH headings : Acetaminophen / toxicity; Analgesics, Non-Narcotic / toxicity; Animals; Biomarkers / analysis; Cell Death / genetics; Cell Proliferation / drug effects; Chemical and Drug Induced Liver Injury / genetics; Chemical and Drug Induced Liver Injury / pathology; Gene Expression / drug effects; Humans; Liver / pathology; Male; Mice; Oligonucleotide Array Sequence Analysis; Polymorphism, Single Nucleotide / drug effects; Population; Principal Component Analysis; RNA / biosynthesis; RNA / isolation & purification; Species Specificity; Toxicogenetics / standards; Transcription, Genetic / drug effects
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Reduced EGFR causes abnormal valvular differentiation leading to calcific aortic stenosis and left ventricular hypertrophy in C57BL/6J but not 129S1/SvImJ mice

American Journal of Physiology-Heart and Circulatory Physiology, 297(1), H65–H75.

By: C. Barrick*, R. Roberts*, M. Rojas, N. Rajamannan, C. Suitt, K. O'Brien*, S. Smyth*, D. Threadgill n

author keywords: epidermal growth factor receptor aortic sclerosis; hypertrophy; aortic stenosis; valvulogenesis
MeSH headings : Alleles; Animals; Aortic Valve Stenosis / diagnostic imaging; Aortic Valve Stenosis / etiology; Aortic Valve Stenosis / pathology; Blood Pressure / physiology; Calcinosis / diagnostic imaging; Calcinosis / etiology; Calcinosis / pathology; Echocardiography; ErbB Receptors / genetics; ErbB Receptors / physiology; Female; Heart Failure / etiology; Heart Failure / pathology; Heart Function Tests; Heart Valves / diagnostic imaging; Heart Valves / growth & development; Hypertrophy, Left Ventricular / diagnostic imaging; Hypertrophy, Left Ventricular / etiology; Hypertrophy, Left Ventricular / pathology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenotype; Phosphorylation; RNA, Messenger / biosynthesis; RNA, Messenger / genetics; Reverse Transcriptase Polymerase Chain Reaction; Species Specificity; Survival
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2009 review

The gastrointestinal microbiome: a malleable, third genome of mammals

[Review of ]. MAMMALIAN GENOME, 20(7), 395–403.

By: I. Carroll*, D. Threadgill n & D. Threadgill n

MeSH headings : Animals; Bacteria / genetics; Bacteria / isolation & purification; Bacterial Infections / microbiology; Gastrointestinal Tract / microbiology; Genome, Bacterial; Humans; Mammals / microbiology; Metagenome
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Tumor-specific apoptosis caused by deletion of the ERBB3 pseudo-kinase in mouse intestinal epithelium

JOURNAL OF CLINICAL INVESTIGATION, 119(9), 2702–2713.

By: D. Lee, M. Yu, E. Lee, H. Kim, Y. Yang, K. Kim, C. Pannicia, J. Kurie, D. Threadgill*

MeSH headings : Animals; Apoptosis / genetics; Apoptosis / physiology; Base Sequence; Caspase 3 / metabolism; Cell Line, Tumor; Colorectal Neoplasms / enzymology; Colorectal Neoplasms / genetics; Colorectal Neoplasms / pathology; ErbB Receptors / antagonists & inhibitors; ErbB Receptors / genetics; Female; Genes, APC; Genes, erbB; Humans; Intestinal Mucosa / enzymology; Intestinal Mucosa / pathology; Male; Mice; Mice, Knockout; Mice, Transgenic; Models, Biological; RNA, Small Interfering / genetics; Receptor, ErbB-3 / antagonists & inhibitors; Receptor, ErbB-3 / deficiency; Receptor, ErbB-3 / genetics; Receptor, ErbB-4
Source: Web Of Science
Added: August 6, 2018