David W Threadgill

Epithelial-specific ERBB3 deletion results in a genetic background-dependent increase in intestinal and colon polyps that is mediated by EGFR

PLOS GENETICS, 17(11).

Derivation of stable embryonic stem cell-like, but transcriptionally heterogenous, induced pluripotent stem cells from non-permissive mouse strains

MAMMALIAN GENOME, 31(9-12), 263–286.

Locally Fixed Alleles: A method to localize gene drive to island populations

SCIENTIFIC REPORTS, 9.

Population-Based Analysis of DNA Damage and Epigenetic Effects of 1,3-Butadiene in the Mouse

CHEMICAL RESEARCH IN TOXICOLOGY, 32(5), 887–898.

Using Collaborative Cross Mouse Population to Fill Data Gaps in Risk Assessment: A Case Study of Population-Based Analysis of Toxicokinetics and Kidney Toxicodynamics of Tetrachloroethylene

ENVIRONMENTAL HEALTH PERSPECTIVES, 127(6).

Permissiveness to form pluripotent stem cells may be an evolutionarily derived characteristic in Mus muscuius

SCIENTIFIC REPORTS, 8.

Sensitivity to hepatotoxicity due to epigallocatechin gallate is affected by genetic background in diversity outbred mice

FOOD AND CHEMICAL TOXICOLOGY, 76, 19–26.

Epidermal growth factor receptor plays a role in the regulation of liver and plasma lipid levels in adult male mice

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 306(5), G370–G381.

Identification and Characterization of an Invasion Antigen B Gene from the Oral Pathogen Campylobacter rectus

INDIAN JOURNAL OF MICROBIOLOGY, 54(1), 33–40.

Status and access to the Collaborative Cross population (vol 23, pg 706, 2012)

Welsh, C. E., Miller, D. R., Manly, K. F., Wang, J., McMillan, L., Morahan, G., … Villena, F. P.-M. (2014, April). MAMMALIAN GENOME, Vol. 25, pp. 192–192.

Conditional Inactivation of TNF alpha-Converting Enzyme in Chondrocytes Results in an Elongated Growth Plate and Shorter Long Bones

PLOS ONE, 8(1).

Identification of a Novel Polymorphism in X-Linked Sterol-4-Alpha-Carboxylate 3-Dehydrogenase (Nsdhl) Associated with Reduced High-Density Lipoprotein Cholesterol Levels in I/LnJ Mice

G3-GENES GENOMES GENETICS, 3(10), 1819–1825.

Modeling Host Genetic Regulation of Influenza Pathogenesis in the Collaborative Cross

PLOS PATHOGENS, 9(2).

Pleiotropic Effects of the Trichloroethylene-Associated P81S VHL Mutation on Metabolism, Apoptosis, and ATM-Mediated DNA Damage Response

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 105(18), 1355–1364.

Tumor fibroblast-derived epiregulin promotes growth of colitis-associated neoplasms through ERK

JOURNAL OF CLINICAL INVESTIGATION, 123(4), 1428–1443.

Using the emerging Collaborative Cross to probe the immune system

Genes & Immunity, 15(1), 38–46.

Both stromal cell and colonocyte epidermal growth factor receptors control HCT116 colon cancer cell growth in tumor xenografts

CARCINOGENESIS, 33(10), 1930–1939.

Dietary calcium supplementation enhances efficacy but also toxicity of EGFR inhibitor therapy for colon cancer

CANCER BIOLOGY & THERAPY, 13(3), 130–137.

EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis

CANCER CELL, 22(3), 304–317.

Efficacy of EGFR Inhibition Is Modulated by Model, Sex, Genetic Background and Diet: Implications for Preclinical Cancer Prevention and Therapy Trials

PLOS ONE, 7(6).

Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation

JOURNAL OF EXPERIMENTAL MEDICINE, 209(6), 1105–1119.

Expression quantitative trait loci for extreme host response to influenza a in pre-collaborative cross mice

G3-Genes Genomes Genetics, 2(2), 213–221.

Genetic Analysis of Hematological Parameters in Incipient Lines of the Collaborative Cross

G3-GENES GENOMES GENETICS, 2(2), 157–165.

Genome-wide association mapping of loci for antipsychotic-induced extrapyramidal symptoms in mice

MAMMALIAN GENOME, 23(5-6), 322–335.

Mapping Six New Susceptibility to Colon Cancer (Scc) Loci Using a Mouse Interspecific Backcross

G3-GENES GENOMES GENETICS, 2(12), 1577–1584.

Status and access to the Collaborative Cross population

MAMMALIAN GENOME, 23(9-10), 706–712.

Ten Years of the Collaborative Cross

G3-GENES GENOMES GENETICS, 2(2), 153–156.

Architecture of energy balance traits in emerging lines of the Collaborative Cross

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 300(6), E1124–E1134.

Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis

Nature Medicine, 17(10), 1242–1272.

Epiregulin-dependent amphiregulin expression and ERBB2 signaling are involved in luteinizing hormone-induced paracrine signaling pathways in mouse ovary

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 405(2), 319–324.

Genetic analysis of complex traits in the emerging Collaborative Cross

GENOME RESEARCH, 21(8), 1213–1222.

Interstrain Differences in the Liver Effects of Trichloroethylene in a Multistrain Panel of Inbred Mice

TOXICOLOGICAL SCIENCES, 120(1), 206–217.

MicroRNA expression in the livers of inbred mice

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 714(1-2), 126–133.

The Collaborative Cross: A Recombinant Inbred Mouse Population for the Systems Genetic Era

ILAR JOURNAL, 52(1), 24–31.

Genetic mapping and developmental timing of transmission ratio distortion in a mouse interspecific backcross

BMC GENETICS, 11.

Maternal Dioxin Exposure Combined with a Diet High in Fat Increases Mammary Cancer Incidence in Mice

ENVIRONMENTAL HEALTH PERSPECTIVES, 118(5), 596–601.

Toxicogenetics: population-based testing of drug and chemical safety in mouse models (vol 11, pg 1127, 2010)

Rusyn, I., Gatti, D. M., Wiltshire, T., Kleeberger, S. R., & Threadgill, D. W. (2010, September). PHARMACOGENOMICS, Vol. 11, pp. 1344–1344.

Animal models of autism spectrum disorders: Information for neurotoxicologists

Halladay, A. K., Amaral, D., Aschner, M., Bolivar, V. J., Bowman, A., DiCicco-Bloom, E., … Threadgill, D. W. (2009, September). NEUROTOXICOLOGY, Vol. 30, pp. 811–821.

Dietary Fat Alters Body Composition, Mammary Development, and Cytochrome P450 Induction after Maternal TCDD Exposure in DBA/2J Mice with Low-Responsive Aryl Hydrocarbon Receptors

ENVIRONMENTAL HEALTH PERSPECTIVES, 117(9), 1414–1419.

Elucidation of the transcription network governing mammalian sex determination by exploiting strain-specific susceptibility to sex reversal

GENES & DEVELOPMENT, 23(21), 2521–2536.

Epidermal Growth Factor Receptor Is Required for Colonic Tumor Promotion by Dietary Fat in the Azoxymethane/Dextran Sulfate Sodium Model: Roles of Transforming Growth Factor-alpha and PTGS2

CLINICAL CANCER RESEARCH, 15(22), 6780–6789.

Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans

GENOME RESEARCH, 19(9), 1507–1515.

Murine models of colorectal cancer

[Review of ]. MAMMALIAN GENOME, 20(5), 261–268.

Placental and Embryonic Growth Restriction in Mice With Reduced Function Epidermal Growth Factor Receptor Alleles

GENETICS, 183(1), 207–218.

Placental overgrowth and fertility defects in mice with a hypermorphic allele of epidermal growth factor receptor

MAMMALIAN GENOME, 20(6), 339–349.

Population-Based Discovery of Toxicogenomics Biomarkers for Hepatotoxicity Using a Laboratory Strain Diversity Panel

TOXICOLOGICAL SCIENCES, 110(1), 235–243.

Reduced EGFR causes abnormal valvular differentiation leading to calcific aortic stenosis and left ventricular hypertrophy in C57BL/6J but not 129S1/SvImJ mice

American Journal of Physiology-Heart and Circulatory Physiology, 297(1), H65–H75.

The gastrointestinal microbiome: a malleable, third genome of mammals

[Review of ]. MAMMALIAN GENOME, 20(7), 395–403.

Tumor-specific apoptosis caused by deletion of the ERBB3 pseudo-kinase in mouse intestinal epithelium

JOURNAL OF CLINICAL INVESTIGATION, 119(9), 2702–2713.