David W Threadgill
Works (50)
Updated: July 26th, 2023 21:16
2023 journal article
Bulk and mosaic deletions of Egfr reveal regionally defined gliogenesis in the developing mouse forebrain
ISCIENCE, 26(3).
TL;DR:
Subtractive bulk ventral and dorsal forebrain deletions of Egfr uncovered significant and permanent decreases in oligodendrogenesis and myelination in the cortex and corpus callosum, and a regenerative population of gliogenic progenitors in the mouse forebrain may compensate for the missing EGFR-dependent dorsal glia in the bulk Egfr-deleted forebrain.
(via Semantic Scholar)
open access via doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 5, 2023
2021 journal article
Epithelial-specific ERBB3 deletion results in a genetic background-dependent increase in intestinal and colon polyps that is mediated by EGFR
PLOS GENETICS, 17(11).
MeSH headings : Adenomatous Polyposis Coli Protein / genetics; Animals; Cell Proliferation / genetics; Colon / metabolism; Colon / pathology; Colonic Polyps / genetics; Colonic Polyps / pathology; Colonic Polyps / therapy; Colorectal Neoplasms / genetics; Colorectal Neoplasms / pathology; Colorectal Neoplasms / therapy; Disease Models, Animal; ErbB Receptors / genetics; Gene Expression Regulation, Neoplastic / genetics; Gene Silencing; Humans; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Intestinal Polyps / genetics; Intestinal Polyps / pathology; Intestinal Polyps / therapy; Mice; Receptor, ErbB-3 / antagonists & inhibitors; Receptor, ErbB-3 / genetics
TL;DR:
Increase polyp number caused by loss of ERBB3 was mediated by increased epidermal growth factor receptor (EGFR) expression, which was confirmed by deletion of Egfr.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: December 13, 2021
2020 journal article
Derivation of stable embryonic stem cell-like, but transcriptionally heterogenous, induced pluripotent stem cells from non-permissive mouse strains
MAMMALIAN GENOME, 31(9-12), 263–286.
MeSH headings : Animals; Biomarkers; Cell Differentiation; Cells, Cultured; Cellular Reprogramming / genetics; Embryonic Stem Cells / cytology; Embryonic Stem Cells / metabolism; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genetic Heterogeneity; Immunophenotyping; Induced Pluripotent Stem Cells / cytology; Induced Pluripotent Stem Cells / metabolism; Mice; Platelet Endothelial Cell Adhesion Molecule-1; Species Specificity; Transcriptome
TL;DR:
Heterogeneity is a naturally occurring, necessary quality of stem cells that allows for the maintenance of pluripotency and this study is the first study to derive stable ESC-like stem cells from the non-permissive NOD/ShiLtJ and WSB/EiJ strains, enabling easier and broader research possibilities into pluripOTency for these and similar non-Permissive mouse strains and species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 19, 2020
2019 journal article
Locally Fixed Alleles: A method to localize gene drive to island populations
SCIENTIFIC REPORTS, 9.
MeSH headings : Alleles; Animals; Biodiversity; Islands
TL;DR:
This paper proposes the “Locally Fixed Alleles” approach as a novel means for localizing elimination by a drive to an island population that exhibits significant genetic isolation from neighboring populations and explores the feasibility and degree of localization that can be achieved.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 18, 2019
2019 journal article
Population-Based Analysis of DNA Damage and Epigenetic Effects of 1,3-Butadiene in the Mouse
CHEMICAL RESEARCH IN TOXICOLOGY, 32(5), 887–898.
MeSH headings : Animals; Butadienes / toxicity; Carcinogens, Environmental / toxicity; DNA Adducts / chemistry; DNA Adducts / genetics; DNA Adducts / metabolism; DNA Methylation / drug effects; Epigenesis, Genetic / drug effects; Guanine / analogs & derivatives; Guanine / chemistry; Histones / metabolism; Kidney / drug effects; Liver / drug effects; Lung / drug effects; Male; Mice; Mutagens / toxicity
TL;DR:
1,3-butadiene is used to demonstrate how the Collaborative Cross mouse population can be used to identify the mechanisms for and quantify the degree of interindividual variability in tissue-specific effects that are relevant to chemically induced carcinogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: June 17, 2019
2019 journal article
Using Collaborative Cross Mouse Population to Fill Data Gaps in Risk Assessment: A Case Study of Population-Based Analysis of Toxicokinetics and Kidney Toxicodynamics of Tetrachloroethylene
ENVIRONMENTAL HEALTH PERSPECTIVES, 127(6).
MeSH headings : Animals; Collaborative Cross Mice; Glutathione / analogs & derivatives; Glutathione / metabolism; Hepatitis A Virus Cellular Receptor 1 / genetics; Hepatitis A Virus Cellular Receptor 1 / metabolism; Kidney / drug effects; Kidney Diseases / chemically induced; Kidney Diseases / metabolism; Liver / drug effects; Male; Risk Assessment / methods; Species Specificity; Tetrachloroethylene / metabolism; Tetrachloroethylene / pharmacokinetics; Tetrachloroethylene / toxicity; Toxicokinetics
TL;DR:
The utility of the CC mouse population is demonstrated in characterizing metabolism–toxicity interactions and quantifying interindividual variability and the default uncertainty factor for human variability may be marginally adequate to protect 95%, but not more, of the population for kidney toxicity mediated by PERC.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: July 29, 2019
2018 journal article
Permissiveness to form pluripotent stem cells may be an evolutionarily derived characteristic in Mus muscuius
SCIENTIFIC REPORTS, 8.
MeSH headings : Animals; Cells, Cultured; Cellular Reprogramming / drug effects; Cellular Reprogramming / genetics; Culture Media / metabolism; Culture Media / pharmacology; Evolution, Molecular; Female; Fibroblasts; Glycogen Synthase Kinase 3 beta / antagonists & inhibitors; Glycogen Synthase Kinase 3 beta / metabolism; Induced Pluripotent Stem Cells; Leukemia Inhibitory Factor / metabolism; MAP Kinase Kinase Kinases / antagonists & inhibitors; MAP Kinase Kinase Kinases / metabolism; Male; Mice / genetics; Mice, Inbred Strains / genetics; Mouse Embryonic Stem Cells; Primary Cell Culture; Protein Kinase Inhibitors / pharmacology; Sex Factors; Transcription, Genetic
TL;DR:
iPSC derived in 2iS are more transcriptionally similar to ESC than EpiSC, indicating that iPSC reprogramming acts to overcome genetic background constraints, and only some M. musculus strains are permissive under LIF culture conditions suggesting that this is an evolutionarily derived characteristic in the M.Mus musculus lineage.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 16, 2018
2014 journal article
Epidermal growth factor receptor plays a role in the regulation of liver and plasma lipid levels in adult male mice
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 306(5), G370–G381.
author keywords: liver; epidermal growth factor; Dsk5; cholesterol; hepatomegaly; low-density lipoprotein receptor
MeSH headings : Adipose Tissue / anatomy & histology; Alleles; Animals; Chondroitin Sulfates; Dermatan Sulfate; ErbB Receptors / genetics; ErbB Receptors / metabolism; Female; Gene Expression Regulation, Developmental / physiology; Heparitin Sulfate; Kidney / anatomy & histology; Lipid Metabolism / physiology; Lipids / blood; Liver / anatomy & histology; Liver / metabolism; Male; Mice; Sarcoma, Small Cell; Signal Transduction; Spleen / anatomy & histology; Testis / anatomy & histology
TL;DR:
It is suggested that the EGFR may play a regulatory role in hepatocyte proliferation and lipid metabolism in adult male mice, explaining why elevated levels of EGF or EGF-like peptides have been positively correlated to increased cholesterol levels in human studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Sensitivity to hepatotoxicity due to epigallocatechin gallate is affected by genetic background in diversity outbred mice
FOOD AND CHEMICAL TOXICOLOGY, 76, 19–26.
author keywords: Green tea; Epigallocatechin gallate; Hepatotoxicity; Population variability; Herbal; Diversity outbred
MeSH headings : Animals; Antioxidants / administration & dosage; Antioxidants / adverse effects; Catechin / administration & dosage; Catechin / adverse effects; Catechin / analogs & derivatives; Chemical and Drug Induced Liver Injury / genetics; Chromosome Mapping; Dose-Response Relationship, Drug; Genotyping Techniques; In Situ Nick-End Labeling; Liver / drug effects; Liver / metabolism; Male; Mice / genetics; Phenotype; Polymorphism, Single Nucleotide; Polyphenols / administration & dosage; Polyphenols / adverse effects; Quantitative Trait Loci; Tea / chemistry
TL;DR:
The data indicate that the Diversity Outbred mice may provide a platform for informing risk of rare, adverse reactions that may occur in consumer populations upon ingestion of concentrated herbal products.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 article
Status and access to the Collaborative Cross population (vol 23, pg 706, 2012)
Welsh, C. E., Miller, D. R., Manly, K. F., Wang, J., McMillan, L., Morahan, G., … Villena, F. P.-M. (2014, April). MAMMALIAN GENOME, Vol. 25, pp. 192–192.
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Conditional Inactivation of TNF alpha-Converting Enzyme in Chondrocytes Results in an Elongated Growth Plate and Shorter Long Bones
PLOS ONE, 8(1).
MeSH headings : ADAM Proteins / genetics; ADAM Proteins / metabolism; ADAM17 Protein; Animals; Bone Development / genetics; Cell Differentiation; Chondrocytes / metabolism; Chondrocytes / physiology; Collagen Type II / genetics; Embryonic Development / genetics; ErbB Receptors / genetics; ErbB Receptors / metabolism; Gene Expression Regulation, Developmental; Growth Plate / growth & development; Growth Plate / metabolism; Male; Matrix Metalloproteinase 13 / metabolism; Mice; Mutation; Osteoprotegerin / metabolism; RANK Ligand / metabolism; Signal Transduction; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
Data suggest that TACE-EGFR signaling in chondrocytes is involved in the turnover of the growth plate during postnatal development via the transcriptional regulation of osteoprotegerin, Rankl, and Mmp-13.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Identification and Characterization of an Invasion Antigen B Gene from the Oral Pathogen Campylobacter rectus
INDIAN JOURNAL OF MICROBIOLOGY, 54(1), 33–40.
author keywords: Campylobacter rectus; Periodontitis; Invasion antigen B; Virulence factor
TL;DR:
Cr-ciaB is the first ciaB identified from the oral campylobacters, which is predicted to lack membrane helices, signal peptides, and localizes to the cytoplasm; which is consistent with CiaB proteins.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Identification of a Novel Polymorphism in X-Linked Sterol-4-Alpha-Carboxylate 3-Dehydrogenase (Nsdhl) Associated with Reduced High-Density Lipoprotein Cholesterol Levels in I/LnJ Mice
G3-GENES GENOMES GENETICS, 3(10), 1819–1825.
author keywords: QTL; genomics; HDL cholesterol; Nsdhl
MeSH headings : 3-Hydroxysteroid Dehydrogenases / genetics; Animals; Animals, Inbred Strains; Apolipoprotein A-II / genetics; Cholesterol, HDL / blood; Cholesterol, HDL / genetics; Genetic Linkage; Lipid Metabolism / genetics; Mice; Polymorphism, Single Nucleotide; Quantitative Trait Loci; X Chromosome / genetics
TL;DR:
There are additional genes left to be identified that control lipid levels and that can provide new pharmaceutical targets, including sterol-4-alpha-carboxylate 3-dehydrogenase in the cholesterol synthesis pathway.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Modeling Host Genetic Regulation of Influenza Pathogenesis in the Collaborative Cross
PLOS PATHOGENS, 9(2).
MeSH headings : Animals; Crosses, Genetic; Female; Genetic Variation; Host-Pathogen Interactions / genetics; Humans; Influenza A virus; Influenza, Human / genetics; Influenza, Human / pathology; Influenza, Human / virology; Lung / pathology; Mice; Mice, Inbred Strains; Models, Genetic; Orthomyxoviridae Infections / genetics; Orthomyxoviridae Infections / pathology; Orthomyxoviridae Infections / virology; Phenotype; Reassortant Viruses / genetics; Reassortant Viruses / pathogenicity; Recombination, Genetic; Rodent Diseases / genetics; Rodent Diseases / pathology; Rodent Diseases / virology; Species Specificity; Virus Replication
TL;DR:
To identify how host genetic polymorphisms contribute to the observed variation in disease, quantitative trait loci (QTL) mapping was conducted and several QTL contributing to specific aspects of the host response including virus-induced weight loss, titer, pulmonary edema, neutrophil recruitment to the airways, and transcriptional expression were identified.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Pleiotropic Effects of the Trichloroethylene-Associated P81S VHL Mutation on Metabolism, Apoptosis, and ATM-Mediated DNA Damage Response
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 105(18), 1355–1364.
MeSH headings : Animals; Apoptosis; Arginine; Ataxia Telangiectasia Mutated Proteins; Carcinoma, Renal Cell / genetics; Carcinoma, Renal Cell / metabolism; Cell Cycle Proteins / metabolism; DNA Damage; DNA-Binding Proteins / metabolism; Embryonic Stem Cells; Glutamine; Humans; Hypoxia-Inducible Factor 1 / metabolism; Immunohistochemistry; Kidney Neoplasms / genetics; Kidney Neoplasms / metabolism; Mice; Occupational Exposure; Point Mutation; Proline; Protein Array Analysis; Protein Serine-Threonine Kinases / metabolism; Serine; Teratoma / genetics; Trichloroethylene / toxicity; Tumor Suppressor Proteins / metabolism; Ubiquitin-Protein Ligases / metabolism; Von Hippel-Lindau Tumor Suppressor Protein / genetics
TL;DR:
The TCE-associated P81S VHL mutation can initiate a unique adaptive response required for selective tumor growth through pleiotropic effects on metabolic diversification, apoptosis suppression, and alteration of the DNA damage response.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Tumor fibroblast-derived epiregulin promotes growth of colitis-associated neoplasms through ERK
JOURNAL OF CLINICAL INVESTIGATION, 123(4), 1428–1443.
MeSH headings : Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colitis / chemically induced; Colitis / complications; Colon / pathology; Colorectal Neoplasms / etiology; Colorectal Neoplasms / pathology; Epidermal Growth Factor / genetics; Epidermal Growth Factor / metabolism; Epidermal Growth Factor / physiology; Epiregulin; Extracellular Signal-Regulated MAP Kinases / metabolism; Fibroblasts / metabolism; Fibroblasts / pathology; Fibroblasts / transplantation; Humans; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Ki-67 Antigen / metabolism; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Transcriptome; Tumor Burden
TL;DR:
The data indicate that EREG and tumor-associated fibroblasts play a crucial role in controlling tumor growth in colitis-associated neoplasms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Using the emerging Collaborative Cross to probe the immune system
Genes & Immunity, 15(1), 38–46.
author keywords: Collaborative Cross; Fc epsilon R; QTL
MeSH headings : Animals; B-Lymphocytes / physiology; CD11c Antigen / metabolism; CD8-Positive T-Lymphocytes / physiology; Genetic Variation; Genome-Wide Association Study; Haplotypes; Immunogenetics / methods; Lymphocyte Subsets / physiology; Mice; Mice, Inbred Strains / genetics; Mice, Inbred Strains / immunology; Quantitative Trait Loci; Receptors, IgE / metabolism; T-Lymphocytes / physiology
TL;DR:
Comparison of overall strain effects in the CC founders with strain effects at QTL in the pre-CC revealed sharp contrasts in the genetic architecture of two traits with significant loci: variation in CD23 can be explained largely by additive genetics at one locus, whereas variation in B-to-T ratio has a more complex etiology.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2012 journal article
Both stromal cell and colonocyte epidermal growth factor receptors control HCT116 colon cancer cell growth in tumor xenografts
CARCINOGENESIS, 33(10), 1930–1939.
MeSH headings : Animals; Apoptosis; Cell Transformation, Neoplastic; Coculture Techniques; Colonic Neoplasms / metabolism; Colonic Neoplasms / pathology; ErbB Receptors / metabolism; HCT116 Cells; Humans; Interleukin-1beta / metabolism; Mice; Stromal Cells / metabolism; Transfection; Transplantation, Heterologous
TL;DR:
Stromal cell and colonocyte EGFRs are required for robust EGFR signals and efficient tumor growth, which involve EGFR-interleukin-1 crosstalk.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Dietary calcium supplementation enhances efficacy but also toxicity of EGFR inhibitor therapy for colon cancer
CANCER BIOLOGY & THERAPY, 13(3), 130–137.
author keywords: colon cancer; EGFR; calcium; mouse models; AG1478; therapy; toxicity
MeSH headings : Animals; Antineoplastic Agents / pharmacology; Antineoplastic Agents / therapeutic use; Antineoplastic Agents / toxicity; Azoxymethane; Calcium / pharmacology; Calcium / therapeutic use; Calcium / toxicity; Cell Line, Tumor; Cell Proliferation / drug effects; Cell Survival / drug effects; Colonic Neoplasms / chemically induced; Colonic Neoplasms / drug therapy; Colonic Neoplasms / pathology; Dietary Supplements; Drug Screening Assays, Antitumor; Drug Synergism; ErbB Receptors / antagonists & inhibitors; Female; Humans; MAP Kinase Signaling System / drug effects; Male; Mice; Mice, Inbred C57BL; Quinazolines / pharmacology; Quinazolines / therapeutic use; Quinazolines / toxicity; Random Allocation; Tumor Burden / drug effects; Tyrphostins / pharmacology; Tyrphostins / therapeutic use; Tyrphostins / toxicity
TL;DR:
Calcium supplementation combined with pharmacologic blockade of EGFR results in an additive effect on tumor growth inhibition in all models and the combined use of dietary calcium supplementation and EGFR inhibitors also resulted in elevated toxicity suggesting that careful consideration be given when combining dietary supplements with prescribed cancer therapies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis
CANCER CELL, 22(3), 304–317.
MeSH headings : ADAM Proteins / genetics; ADAM Proteins / metabolism; ADAM17 Protein; Animals; Carcinoma, Pancreatic Ductal / genetics; Carcinoma, Pancreatic Ductal / metabolism; Carcinoma, Pancreatic Ductal / pathology; Cell Line, Tumor; Cell Transformation, Neoplastic; Epithelial Cells; ErbB Receptors / biosynthesis; ErbB Receptors / genetics; ErbB Receptors / metabolism; Extracellular Signal-Regulated MAP Kinases / metabolism; Genes, ras; Humans; Mice; Mice, Transgenic; Pancreas / metabolism; Pancreas / pathology; Pancreatic Neoplasms / genetics; Pancreatic Neoplasms / metabolism; Pancreatic Neoplasms / pathology; Proto-Oncogene Proteins p21(ras) / biosynthesis; Proto-Oncogene Proteins p21(ras) / genetics; Proto-Oncogene Proteins p21(ras) / metabolism
TL;DR:
It is shown that oncogenic KRAS upregulates endogenous EGFR expression and activation, the latter being dependent on the EGFR ligand sheddase, ADAM17, which effectively eliminates KRAS-driven tumorigenesis in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Efficacy of EGFR Inhibition Is Modulated by Model, Sex, Genetic Background and Diet: Implications for Preclinical Cancer Prevention and Therapy Trials
PLOS ONE, 7(6).
MeSH headings : Animals; Antineoplastic Agents / pharmacology; Antineoplastic Agents / therapeutic use; Azoxymethane / toxicity; Colorectal Neoplasms / chemically induced; Colorectal Neoplasms / drug therapy; Colorectal Neoplasms / genetics; Diet; Disease Models, Animal; ErbB Receptors / antagonists & inhibitors; ErbB Receptors / metabolism; Female; Male; Mice; Mice, Inbred C57BL; Phosphorylation; Quinazolines / pharmacology; Quinazolines / therapeutic use; Sex Factors; Tyrphostins / pharmacology; Tyrphostins / therapeutic use
TL;DR:
Model-dependent interactions between genetic background and diet can dramatically impact preclinical results, and indicate that low predictive values of preclinical studies can be attributed to study designs that do not account for the heterogeneous patient population or the diets they consume.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation
JOURNAL OF EXPERIMENTAL MEDICINE, 209(6), 1105–1119.
MeSH headings : ADAM Proteins / genetics; ADAM Proteins / metabolism; ADAM17 Protein; Administration, Topical; Animals; Animals, Newborn; Cell Differentiation / physiology; Dermatitis, Atopic / pathology; Epidermal Cells; Epidermis / metabolism; Epidermis / pathology; ErbB Receptors / genetics; ErbB Receptors / metabolism; Gene Expression Regulation, Developmental; Interleukin-1 / metabolism; Keratinocytes / cytology; Keratinocytes / metabolism; Macrophages / pathology; Mice; Mice, Mutant Strains; Skin / cytology; Skin / growth & development; Skin / metabolism; Transforming Growth Factor alpha / administration & dosage; Transforming Growth Factor alpha / genetics; Transforming Growth Factor alpha / pharmacology; Transglutaminases / metabolism
TL;DR:
EGFR requires ADAM17 activity to preserve skin barrier homeostasis and needs to be tuned to prevent cell reprograming and cell death.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Expression quantitative trait loci for extreme host response to influenza a in pre-collaborative cross mice
G3-Genes Genomes Genetics, 2(2), 213–221.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Genetic Analysis of Hematological Parameters in Incipient Lines of the Collaborative Cross
G3-GENES GENOMES GENETICS, 2(2), 157–165.
author keywords: Mouse Genetic Resource; Mouse Collaborative Cross hematology hemoglobin beta mean red cell volume; QTL mouse genetics complex traits shared ancestry
TL;DR:
This work used a newly developed mouse resource population, the Collaborative Cross, to identify genetic determinants of hematological parameters and used evolutionary principles and unique bioinformatics resources to reduce the size of candidate intervals and to view functional variation in the context of phylogeny.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Mapping Six New Susceptibility to Colon Cancer (Scc) Loci Using a Mouse Interspecific Backcross
G3-GENES GENOMES GENETICS, 2(12), 1577–1584.
author keywords: spretus; cancer modifier; colorectal cancer
MeSH headings : Alleles; Animals; Chromosome Mapping; Chromosomes / genetics; Colonic Neoplasms / genetics; Colonic Neoplasms / metabolism; Crosses, Genetic; Genetic Predisposition to Disease; Genome; Genotype; Mice; Phenotype; Quantitative Trait Loci
TL;DR:
This work confirms genetic models suggesting that CRC is caused by many small effect alleles and brings the catalog of reported CRC modifier loci to 23 spread across 13 chromosomes, and provides the foundation for large population-level epistatic interaction tests to identify combinations of low effect allele that may have large effects on CRC susceptibility.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Status and access to the Collaborative Cross population
MAMMALIAN GENOME, 23(9-10), 706–712.
MeSH headings : Animals; Cooperative Behavior; Genome; Internet; Male; Mice; Mice, Inbred Strains / genetics
TL;DR:
The three breeding sites, in the US, Israel, and Australia, are actively collaborating to accelerate the inbreeding process through marker-assisted inbreeding and to expedite community access of CC lines deemed to have reached defined thresholds of inbreeding.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Ten Years of the Collaborative Cross
G3-GENES GENOMES GENETICS, 2(2), 153–156.
TL;DR:
The February 2012 issues of GENETICS and G3: Genes, Genomes, Genetics present a collection of articles reporting recent advances from the international Collaborative Cross (CC) project, which aims to develop a new resource that will enhance quantitative trait locus (QTL) and systems genetic analyses in mice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Architecture of energy balance traits in emerging lines of the Collaborative Cross
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 300(6), E1124–E1134.
author keywords: genetics; wheel running; adiposity; body weight; quantitative trait loci
MeSH headings : Alleles; Analysis of Variance; Animals; Body Fat Distribution; Body Weight / genetics; Body Weight / physiology; Chromosome Mapping; Chromosomes / genetics; Crosses, Genetic; Eating / genetics; Eating / physiology; Energy Metabolism / genetics; Energy Metabolism / physiology; Genotype; Linkage Disequilibrium; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Motor Activity / physiology; Phenotype; Physical Conditioning, Animal / physiology; Quantitative Trait Loci; Running / physiology; Sample Size
TL;DR:
The results suggest that the CC will be a powerful, high-precision tool for examining the genetic architecture of complex traits such as those involved in regulation of energy balance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis
Nature Medicine, 17(10), 1242–1272.
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
Epiregulin-dependent amphiregulin expression and ERBB2 signaling are involved in luteinizing hormone-induced paracrine signaling pathways in mouse ovary
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 405(2), 319–324.
author keywords: Amphiregulin; Epiregulin; EGFR and ERBB2 phosphorylation; Oocyte maturation; Ovulation
MeSH headings : Amphiregulin; Animals; EGF Family of Proteins; Epidermal Growth Factor / genetics; Epidermal Growth Factor / metabolism; Epiregulin; ErbB Receptors / metabolism; Female; Glycoproteins / biosynthesis; Glycoproteins / genetics; Intercellular Signaling Peptides and Proteins / biosynthesis; Intercellular Signaling Peptides and Proteins / genetics; Luteinizing Hormone / metabolism; Meiosis; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Ovary / cytology; Ovary / metabolism; Ovary / physiology; Ovulation; Phosphorylation; RNA, Messenger / biosynthesis; Receptor, ErbB-2 / metabolism; Signal Transduction
TL;DR:
This study implicates that EREG mediates signals downstream of Areg mRNA expression and that EGFR-ERBB2 signals contributes to regulation of ovulation process.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Genetic analysis of complex traits in the emerging Collaborative Cross
GENOME RESEARCH, 21(8), 1213–1222.
MeSH headings : Animals; Crosses, Genetic; Female; Gene Expression; Genetic Association Studies; Genome; Haplotypes; Male; Mice; Phenotype; Quantitative Trait Loci
TL;DR:
It is demonstrated that the genetic diversity of the CC, which derives from random mixing of eight founder strains, results in high phenotypic diversity and enhances the ability to map causative loci underlying complex disease-related traits.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Genome-wide association mapping of loci for antipsychotic-induced extrapyramidal symptoms in mice
MAMMALIAN GENOME, 23(5-6), 322–335.
MeSH headings : Animals; Antipsychotic Agents / adverse effects; Basal Ganglia Diseases / chemically induced; Basal Ganglia Diseases / genetics; Basal Ganglia Diseases / physiopathology; Chromosome Mapping; Dyskinesia, Drug-Induced / genetics; Dyskinesia, Drug-Induced / physiopathology; Female; Genome-Wide Association Study; Humans; Male; Mice; Mice, Inbred A; Motor Activity; Polymorphism, Single Nucleotide
TL;DR:
A validated mouse model was used for a systems genetics analysis geared toward detecting genetic predictors of TD in human patients and identified ~50 genes that are expected to have high prior probabilities for association with haloperidol-induced TD.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
MicroRNA expression in the livers of inbred mice
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 714(1-2), 126–133.
author keywords: MicroRNA; Liver; Mouse; Gene expression
MeSH headings : Animals; Gene Expression; Liver / metabolism; Mice; Mice, Inbred Strains / genetics; MicroRNAs / metabolism; Polymorphism, Single Nucleotide
TL;DR:
The stability of mouse liver miRNA expression in a genetically diverse population suggests that treatment-induced disruptions in liver mi RNA expression may indicate an important mechanism for the disturbance of normal liver function, and may prove to be a useful genetic background-independent biomarker of toxicant effect.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2011 journal article
The Collaborative Cross: A Recombinant Inbred Mouse Population for the Systems Genetic Era
ILAR JOURNAL, 52(1), 24–31.
author keywords: aging; Collaborative Cross (CC); mouse model; recombinant inbred mice; systems genetics; genetic reference population
MeSH headings : Aging / genetics; Aging / physiology; Animals; Crosses, Genetic; Mice; Models, Animal
TL;DR:
The Collaborative Cross (CC) is a large panel of recently established multiparental recombinant inbred mouse lines specifically designed to overcome the limitations of existing mouse genetic resources for analysis of phenotypes caused by combinatorial allele effects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Genetic mapping and developmental timing of transmission ratio distortion in a mouse interspecific backcross
BMC GENETICS, 11.
MeSH headings : Alleles; Animals; Chromosome Mapping; Female; Genotype; Hybridization, Genetic; Inheritance Patterns; Male; Mice / genetics; Mice, Inbred A; Microsatellite Repeats; Models, Genetic
TL;DR:
The results are consistent with the TRD mechanism being deviation from Mendelian inheritance rather than meiotic drive or segregation distortion, and the underlying causes for the interspecific TRD events are the differential post-natal survival of pups with specific genotypes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Interstrain Differences in the Liver Effects of Trichloroethylene in a Multistrain Panel of Inbred Mice
TOXICOLOGICAL SCIENCES, 120(1), 206–217.
author keywords: trichloroethylene; metabolism; genetics; peroxisome proliferator-activated receptor alpha; acute exposure; gene expression
MeSH headings : Animals; Environmental Pollutants / blood; Environmental Pollutants / metabolism; Environmental Pollutants / toxicity; Gene Expression / drug effects; Gene Expression Profiling; Liver / drug effects; Liver / metabolism; Liver / pathology; Male; Mice; Mice, Inbred Strains; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; Species Specificity; Trichloroethylene / blood; Trichloroethylene / metabolism; Trichloroethylene / toxicity
TL;DR:
These studies provide better understanding of the mechanisms of TCE-induced toxicity anchored on metabolism and genotype-phenotype correlations that may define susceptibility or resistance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 article
Toxicogenetics: population-based testing of drug and chemical safety in mouse models (vol 11, pg 1127, 2010)
Rusyn, I., Gatti, D. M., Wiltshire, T., Kleeberger, S. R., & Threadgill, D. W. (2010, September). PHARMACOGENOMICS, Vol. 11, pp. 1344–1344.
MeSH headings : Animals; Disease Models, Animal; Drug Evaluation, Preclinical / methods; Drug-Related Side Effects and Adverse Reactions / genetics; Humans; Mice; Quantitative Trait Loci / genetics; Species Specificity; Toxicogenetics / methods
TL;DR:
It is posited that appropriate genetically defined mouse models may be combined with the limited data from human studies to not only discover the genetic determinants of susceptibility, but to also understand the molecular underpinnings of toxicity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 article
Animal models of autism spectrum disorders: Information for neurotoxicologists
Halladay, A. K., Amaral, D., Aschner, M., Bolivar, V. J., Bowman, A., DiCicco-Bloom, E., … Threadgill, D. W. (2009, September). NEUROTOXICOLOGY, Vol. 30, pp. 811–821.
author keywords: Animal models; Autism; Neurotoxicology; Symposium
MeSH headings : Animals; Child; Child Development Disorders, Pervasive / chemically induced; Child Development Disorders, Pervasive / genetics; Child Development Disorders, Pervasive / physiopathology; Child, Preschool; Disease Models, Animal; Drosophila melanogaster; Environment; Genetic Predisposition to Disease; Humans; Mice; Neurotoxicity Syndromes / complications; Toxicology
TL;DR:
The aim of the symposium was to provide researchers with up-to-date information on both the genetics of autism and how they are used in differing in vivo and in vitro animal models as well as to provide a background on the environmental exposures being tested on several animal models.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Dietary Fat Alters Body Composition, Mammary Development, and Cytochrome P450 Induction after Maternal TCDD Exposure in DBA/2J Mice with Low-Responsive Aryl Hydrocarbon Receptors
ENVIRONMENTAL HEALTH PERSPECTIVES, 117(9), 1414–1419.
author keywords: aryl hydrocarbon receptor; fetal loss; gene-environment interactions; mouse; obesity; 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
MeSH headings : Animals; Body Composition; Cytochrome P-450 Enzyme System / biosynthesis; Dietary Fats / administration & dosage; Enzyme Induction; Female; Mammary Glands, Animal / growth & development; Mammary Glands, Animal / metabolism; Maternal Exposure; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Polychlorinated Dibenzodioxins / toxicity; Pregnancy; Receptors, Aryl Hydrocarbon / metabolism
TL;DR:
D2 progeny fed a diet similar to that consumed by most people are susceptible to TCDD and DMBA exposure effects blood glucose levels, mammary differentiation, and hepatic Cyp1 expression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Elucidation of the transcription network governing mammalian sex determination by exploiting strain-specific susceptibility to sex reversal
GENES & DEVELOPMENT, 23(21), 2521–2536.
author keywords: Sex determination; genetical genomics; systems genetics; eQTL; transcription networks; organogenesis
MeSH headings : Animals; Breeding; Cluster Analysis; Disorders of Sex Development; Female; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genetic Variation; Gonads / metabolism; Male; Mice; Mice, Inbred C57BL; Quantitative Trait Loci / genetics; SOX9 Transcription Factor / metabolism; Sex Determination Processes; X Chromosome / genetics; Y Chromosome / genetics
TL;DR:
The results reveal the complex transcription architecture underlying sex determination, and provide a mechanism by which individuals may be sensitized for sex reversal, and estimated the F2 coexpression network and predicted roles for genes of unknown function based on their connectivity and position within the network.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Epidermal Growth Factor Receptor Is Required for Colonic Tumor Promotion by Dietary Fat in the Azoxymethane/Dextran Sulfate Sodium Model: Roles of Transforming Growth Factor-alpha and PTGS2
CLINICAL CANCER RESEARCH, 15(22), 6780–6789.
MeSH headings : Animals; Azoxymethane / pharmacology; Blood Glucose / metabolism; Colonic Neoplasms / metabolism; Cyclooxygenase 2 / metabolism; Dextran Sulfate / pharmacology; ErbB Receptors / metabolism; Gene Expression Regulation, Neoplastic; Insulin / blood; Insulin Resistance; Ligands; Mice; Mice, Inbred C57BL; Point Mutation; Transforming Growth Factor alpha / metabolism
TL;DR:
Egfrwt mice gained significantly more weight and had exaggerated insulin resistance compared with Egfrwa2 mice on high-fat diet, and EGFR-dependent increases in receptor ligands and PTGS2 likely drive diet-related tumor promotion.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Maternal Dioxin Exposure Combined with a Diet High in Fat Increases Mammary Cancer Incidence in Mice
ENVIRONMENTAL HEALTH PERSPECTIVES, 118(5), 596–601.
author keywords: COMT; CYP1B1; dioxin; high-fat diet; mammary cancer; puberty
MeSH headings : Animals; Aryl Hydrocarbon Hydroxylases / genetics; Catechol O-Methyltransferase / genetics; Cocarcinogenesis; Cytochrome P-450 CYP1B1; Dietary Fats / administration & dosage; Dietary Fats / adverse effects; Environmental Pollutants / administration & dosage; Environmental Pollutants / toxicity; Estrogens, Non-Steroidal / administration & dosage; Estrogens, Non-Steroidal / toxicity; Female; Gene Expression / drug effects; Humans; Mammary Neoplasms, Experimental / etiology; Mammary Neoplasms, Experimental / genetics; Mammary Neoplasms, Experimental / pathology; Mice; Polychlorinated Dibenzodioxins / administration & dosage; Polychlorinated Dibenzodioxins / toxicity; Pregnancy; Prenatal Exposure Delayed Effects / etiology; Risk Factors
TL;DR:
The data suggest that the HFD increases sensitivity to maternal TCDD exposure, resulting in increased breast cancer incidence, by changing metabolism capability, which provides a mechanism to explain epidemiological data linking early-life T CDD exposure and diets high in fat to increased risk for breast cancer in humans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans
GENOME RESEARCH, 19(9), 1507–1515.
MeSH headings : Acetaminophen / administration & dosage; Acetaminophen / adverse effects; Alanine Transaminase / blood; Animals; Chemical and Drug Induced Liver Injury / genetics; Chemical and Drug Induced Liver Injury / physiopathology; Cohort Studies; Genetic Predisposition to Disease; Humans; Hyaluronan Receptors / chemistry; Hyaluronan Receptors / genetics; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Polymorphism, Genetic; Sequence Analysis, DNA / methods; Species Specificity
TL;DR:
A diverse mouse population can be used to understand and predict adverse toxicity in heterogeneous human populations through guided resequencing and it is demonstrated that variation in the orthologous human gene, CD44, is associated with susceptibility to acetaminophen in two independent cohorts.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 review
Murine models of colorectal cancer
[Review of ]. MAMMALIAN GENOME, 20(5), 261–268.
MeSH headings : Animals; Colorectal Neoplasms / genetics; Colorectal Neoplasms / metabolism; Colorectal Neoplasms / pathology; Disease Models, Animal; Humans; Mice; Mice, Inbred Strains; Proto-Oncogene Proteins c-myc / genetics; Proto-Oncogene Proteins c-myc / metabolism; Signal Transduction
TL;DR:
This review focuses on the variety of murine models of human colorectal cancer that are available to the research community and on their use to identify common and distinct characteristics of coloreCTal cancer.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Placental and Embryonic Growth Restriction in Mice With Reduced Function Epidermal Growth Factor Receptor Alleles
GENETICS, 183(1), 207–218.
MeSH headings : Alleles; Animals; Animals, Newborn; Embryo, Mammalian; Female; Fetal Growth Retardation / genetics; Fetal Growth Retardation / mortality; Fetal Growth Retardation / pathology; Genes, erbB-1 / physiology; Homozygote; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Transgenic; Organ Size / genetics; Placenta / pathology; Placenta Diseases / genetics; Placenta Diseases / mortality; Placenta Diseases / pathology; Placentation; Pregnancy; Species Specificity
TL;DR:
It is suggested that Egfrwa2 homozygous embryos model EGFR-mediated intrauterine growth restriction in humans and differential expression in the placenta of Glut3, a glucose transporter essential for normal embryonic growth, may contribute to strain-dependent differences in intrauterne growth restriction caused by reduced EGFR activity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Placental overgrowth and fertility defects in mice with a hypermorphic allele of epidermal growth factor receptor
MAMMALIAN GENOME, 20(6), 339–349.
MeSH headings : Alleles; Animals; ErbB Receptors / genetics; ErbB Receptors / metabolism; Female; Fertility; Gene Expression; Male; Mice / genetics; Mice / growth & development; Mice / physiology; Mice, Inbred Strains; Mice, Transgenic; Ovary / physiology; Placenta / metabolism; Placentation; Signal Transduction; Uterus / growth & development; Uterus / physiology
TL;DR:
It is demonstrated that mice with increased levels of EGFR signaling exhibit an extensive level of genetic background-dependent phenotypic variability and EGFR expressed in the uterine stroma may play an underappreciated role in preparation of the uterus for embryo implantation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Population-Based Discovery of Toxicogenomics Biomarkers for Hepatotoxicity Using a Laboratory Strain Diversity Panel
TOXICOLOGICAL SCIENCES, 110(1), 235–243.
author keywords: biomarkers; toxicogenomics; acetaminophen; microarray; liver; phenotypic anchoring
MeSH headings : Acetaminophen / toxicity; Analgesics, Non-Narcotic / toxicity; Animals; Biomarkers / analysis; Cell Death / genetics; Cell Proliferation / drug effects; Chemical and Drug Induced Liver Injury / genetics; Chemical and Drug Induced Liver Injury / pathology; Gene Expression / drug effects; Humans; Liver / pathology; Male; Mice; Oligonucleotide Array Sequence Analysis; Polymorphism, Single Nucleotide / drug effects; Population; Principal Component Analysis; RNA / biosynthesis; RNA / isolation & purification; Species Specificity; Toxicogenetics / standards; Transcription, Genetic / drug effects
TL;DR:
The data demonstrate that a multistrain approach may provide utility for understanding genotype-independent toxicity responses and facilitate identification of novel targets of therapeutic intervention.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Reduced EGFR causes abnormal valvular differentiation leading to calcific aortic stenosis and left ventricular hypertrophy in C57BL/6J but not 129S1/SvImJ mice
American Journal of Physiology-Heart and Circulatory Physiology, 297(1), H65–H75.
author keywords: epidermal growth factor receptor aortic sclerosis; hypertrophy; aortic stenosis; valvulogenesis
MeSH headings : Alleles; Animals; Aortic Valve Stenosis / diagnostic imaging; Aortic Valve Stenosis / etiology; Aortic Valve Stenosis / pathology; Blood Pressure / physiology; Calcinosis / diagnostic imaging; Calcinosis / etiology; Calcinosis / pathology; Echocardiography; ErbB Receptors / genetics; ErbB Receptors / physiology; Female; Heart Failure / etiology; Heart Failure / pathology; Heart Function Tests; Heart Valves / diagnostic imaging; Heart Valves / growth & development; Hypertrophy, Left Ventricular / diagnostic imaging; Hypertrophy, Left Ventricular / etiology; Hypertrophy, Left Ventricular / pathology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenotype; Phosphorylation; RNA, Messenger / biosynthesis; RNA, Messenger / genetics; Reverse Transcriptase Polymerase Chain Reaction; Species Specificity; Survival
TL;DR:
The results show the requirement of EGFR activity for normal valvulogenesis and demonstrate that dominantly acting genetic modifiers curtail pathological changes in congenitally deformed valves.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2009 review
The gastrointestinal microbiome: a malleable, third genome of mammals
[Review of ]. MAMMALIAN GENOME, 20(7), 395–403.
MeSH headings : Animals; Bacteria / genetics; Bacteria / isolation & purification; Bacterial Infections / microbiology; Gastrointestinal Tract / microbiology; Genome, Bacterial; Humans; Mammals / microbiology; Metagenome
TL;DR:
The current knowledge of the gastrointestinal microbiome, its relationship to human health and disease with a particular focus on mammalian physiology, and efforts to alter its composition as a novel therapeutic approach are reviewed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Tumor-specific apoptosis caused by deletion of the ERBB3 pseudo-kinase in mouse intestinal epithelium
JOURNAL OF CLINICAL INVESTIGATION, 119(9), 2702–2713.
MeSH headings : Animals; Apoptosis / genetics; Apoptosis / physiology; Base Sequence; Caspase 3 / metabolism; Cell Line, Tumor; Colorectal Neoplasms / enzymology; Colorectal Neoplasms / genetics; Colorectal Neoplasms / pathology; ErbB Receptors / antagonists & inhibitors; ErbB Receptors / genetics; Female; Genes, APC; Genes, erbB; Humans; Intestinal Mucosa / enzymology; Intestinal Mucosa / pathology; Male; Mice; Mice, Knockout; Mice, Transgenic; Models, Biological; RNA, Small Interfering / genetics; Receptor, ErbB-3 / antagonists & inhibitors; Receptor, ErbB-3 / deficiency; Receptor, ErbB-3 / genetics; Receptor, ErbB-4
TL;DR:
It is shown that the intestinal epithelium of mice with intestine-specific genetic ablation of Erbb3 exhibits no cytological abnormalities but does exhibit loss of expression of ERBB4 and sensitivity to intestinal damage, and this results indicate that the ERBB3 pseudo-kinase has essential roles in supporting intestinal tumorigenesis and suggest that ER BB3 may be a promising target for the treatment of colorectal cancers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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