David W Threadgill

Examining risk assessment implications of genetic and dose-dependent dynamics of lead exposure in breastfeeding using the collaborative cross mouse population

Cuomo, D., Song, Z., Nitcher, M., Lynch, R., Barba, E., Feinberg, A. P., … Threadgill, D. W. (2025, January 30). Toxicological Sciences.

Bulk and mosaic deletions of Egfr reveal regionally defined gliogenesis in the developing mouse forebrain

IScience, 26(3), 106242.

Epithelial-specific ERBB3 deletion results in a genetic background-dependent increase in intestinal and colon polyps that is mediated by EGFR

Rojas, C. M., McGill, M. P., Salvador, A. C., Bautz, D., & Threadgill, D. W. (2021, November 29). PLoS Genetics.

Derivation of stable embryonic stem cell-like, but transcriptionally heterogenous, induced pluripotent stem cells from non-permissive mouse strains

Garbutt, T. A., Konganti, K., Konneker, T., Hillhouse, A., Phelps, D., Jones, A., … Threadgill, D. W. (2020, October 4). Mammalian Genome, Vol. 31, pp. 263–286.

Locally Fixed Alleles: A method to localize gene drive to island populations

Sudweeks, J., Hollingsworth, B., Blondel, D. V., Campbell, K. J., Dhole, S., Eisemann, J. D., … Lloyd, A. L. (2019, November 1). Scientific Reports, Vol. 9.

Population-Based Analysis of DNA Damage and Epigenetic Effects of 1,3-Butadiene in the Mouse

Lewis, L., Borowa-Mazgaj, B., Conti, A., Chappell, G. A., Luo, Y.-S., Bodnar, W., … Rusyn, I. (2019, April 16). Chemical Research in Toxicology.

Using Collaborative Cross Mouse Population to Fill Data Gaps in Risk Assessment: A Case Study of Population-Based Analysis of Toxicokinetics and Kidney Toxicodynamics of Tetrachloroethylene

Luo, Y.-S., Cichocki, J. A., Hsieh, N.-H., Lewis, L., Wright, F. A., Threadgill, D. W., … Rusyn, I. (2019, June 1). Environmental Health Perspectives.

Permissiveness to form pluripotent stem cells may be an evolutionarily derived characteristic in Mus musculus

Garbutt, T. A., Konneker, T. I., Konganti, K., Hillhouse, A. E., Swift-Haire, F., Jones, A., … Threadgill, D. W. (2018, September 26). Scientific Reports, Vol. 8.

Epidermal growth factor receptor plays a role in the regulation of liver and plasma lipid levels in adult male mice

Scheving, L. A., Zhang, X., Garcia, O. A., Wang, R. F., Stevenson, M. C., Threadgill, D. W., & Russell, W. E. (2014, January 10). American Journal of Physiology-Gastrointestinal and Liver Physiology.

Erratum to: Status and access to the Collaborative Cross population

Welsh, C. E., Miller, D. R., Manly, K. F., Wang, J., McMillan, L., Morahan, G., … Villena, F. P.-M. (2014, January 17). Mammalian Genome.

Sensitivity to hepatotoxicity due to epigallocatechin gallate is affected by genetic background in diversity outbred mice

Church, R. J., Gatti, D. M., Urban, T. J., Long, N., Shi, Q., Eaddy, J. S., … Harrill, A. H. (2014, November 29). Food and Chemical Toxicology.

Conditional Inactivation of TNFα-Converting Enzyme in Chondrocytes Results in an Elongated Growth Plate and Shorter Long Bones

Saito, K., Horiuchi, K., Kimura, T., Mizuno, S., Yoda, M., Morioka, H., … Sato, K. (2013, January 18). PLoS ONE.

Identification and Characterization of an Invasion Antigen B Gene from the Oral Pathogen Campylobacter rectus

LaGier, M. J., & Threadgill, D. S. (2013, April 20). Indian Journal of Microbiology.

Identification of a Novel Polymorphism in X-Linked Sterol-4-Alpha-Carboxylate 3-Dehydrogenase (Nsdhl) Associated with Reduced High-Density Lipoprotein Cholesterol Levels in I/LnJ Mice

Bautz, D. J., Broman, K. W., & Threadgill, D. W. (2013, August 27). G3 Genes Genomes Genetics.

Modeling Host Genetic Regulation of Influenza Pathogenesis in the Collaborative Cross

PLoS Pathogens, 9(2), e1003196.

Pleiotropic Effects of the Trichloroethylene-Associated P81S VHL Mutation on Metabolism, Apoptosis, and ATM-Mediated DNA Damage Response

DeSimone, M. C., Rathmell, W. K., & Threadgill, D. W. (2013, August 29). JNCI Journal of the National Cancer Institute.

Tumor fibroblast–derived epiregulin promotes growth of colitis-associated neoplasms through ERK

Neufert, C., Becker, C., Türeci, Ö., Waldner, M. J., Backert, I., Floh, K., … Neurath, M. F. (2013, March 14). Journal of Clinical Investigation.

Using the emerging Collaborative Cross to probe the immune system

Genes & Immunity, 15(1), 38–46.

Both stromal cell and colonocyte epidermal growth factor receptors control HCT116 colon cancer cell growth in tumor xenografts

Mustafi, R., Dougherty, U., Shah, H., Dehghan, H., Gliksberg, A., Wu, J., … Bissonnette, M. (2012, July 12). Carcinogenesis.

Dietary calcium supplementation enhances efficacy but also toxicity of EGFR inhibitor therapy for colon cancer

Rinella, E., Bankaitis, E., & Threadgill, D. (2012, February 1). Cancer Biology & Therapy.

EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis

Ardito, C. M., Grüner, B. M., Takeuchi, K. K., Lubeseder-Martellato, C., Teichmann, N., Mazur, P. K., … Siveke, J. T. (2012, September 1). Cancer Cell.

Efficacy of EGFR Inhibition Is Modulated by Model, Sex, Genetic Background and Diet: Implications for Preclinical Cancer Prevention and Therapy Trials

Rinella, E. S., & Threadgill, D. W. (2012, June 25). PLoS ONE.

Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand–dependent terminal keratinocyte differentiation

Franzke, C.-W., Cobzaru, C., Triantafyllopoulou, A., Löffek, S., Horiuchi, K., Threadgill, D. W., … Blobel, C. P. (2012, May 7). The Journal of Experimental Medicine.

Expression quantitative trait loci for extreme host response to influenza a in pre-collaborative cross mice

G3-Genes Genomes Genetics, 2(2), 213–221.

Genetic Analysis of Hematological Parameters in Incipient Lines of the Collaborative Cross

G3 Genes|Genomes|Genetics, 2(2), 157–165.

Mapping Six New Susceptibility to Colon Cancer (Scc) Loci Using a Mouse Interspecific Backcross

Eversley, C. D., Yuying, X., Pearsall, R. S., & Threadgill, D. W. (2012, December 1). G3 Genes Genomes Genetics.

Status and access to the Collaborative Cross population

Welsh, C. E., Miller, D. R., Manly, K. F., Wang, J., McMillan, L., Morahan, G., … Villena, F. P.-M. (2012, July 30). Mammalian Genome.

Ten Years of the Collaborative Cross

Threadgill, D. W., & Churchill, G. A. (2012, February 1). G3 Genes Genomes Genetics.

Architecture of energy balance traits in emerging lines of the Collaborative Cross

Mathes, W. F., Aylor, D. L., Miller, D. R., Churchill, G. A., Chesler, E. J., Villena, F. P.-M., … Pomp, D. (2011, March 23). American Journal of Physiology-Endocrinology and Metabolism, Vol. 300, pp. E1124–E1134.

Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis

Nature Medicine, 17(10), 1242–1272.

Epiregulin-dependent amphiregulin expression and ERBB2 signaling are involved in luteinizing hormone-induced paracrine signaling pathways in mouse ovary

Kim, K., Lee, H., Threadgill, D. W., & Lee, D. (2011, January 14). Biochemical and Biophysical Research Communications.

Genetic analysis of complex traits in the emerging Collaborative Cross

Genome Research, 21(8), 1213–1222.

Genome-wide association mapping of loci for antipsychotic-induced extrapyramidal symptoms in mice

Crowley, J. J., Kim, Y., Szatkiewicz, J. P., Pratt, A. L., Quackenbush, C. R., Adkins, D. E., … Sullivan, P. F. (2011, December 29). Mammalian Genome.

MicroRNA expression in the livers of inbred mice

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 714(1-2), 126–133.

The Collaborative Cross: A Recombinant Inbred Mouse Population for the Systems Genetic Era

Threadgill, D. W., Miller, D. R., Churchill, G. A., & Villena, F. P.-M. (2011, January 1). ILAR Journal.

Genetic mapping and developmental timing of transmission ratio distortion in a mouse interspecific backcross

Eversley, C. D., Clark, T., Xie, Y., Steigerwalt, J., Bell, T. A., Villena, F. P. M., & Threadgill, D. W. (2010, November 3). BMC Genetics.

Interstrain Differences in the Liver Effects of Trichloroethylene in a Multistrain Panel of Inbred Mice

Bradford, B. U., Lock, E. F., Kosyk, O., Kim, S., Uehara, T., Harbourt, D., … Rusyn, I. (2010, December 6). Toxicological Sciences.

Toxicogenetics: Population-Based Testing of Drug and Chemical Safety in Mouse Models

Rusyn, I., Gatti, D. M., Wilshire, T., Kleeberger, S. R., & Threadgill, D. W. (2010, August 1). Pharmacogenomics.

Animal models of autism spectrum disorders: Information for neurotoxicologists

Halladay, A. K., Amaral, D., Aschner, M., Bolivar, V. J., Bowman, A., DiCicco-Bloom, E., … Threadgill, D. W. (2009, July 10). NeuroToxicology.

Dietary Fat Alters Body Composition, Mammary Development, and Cytochrome P450 Induction after Maternal TCDD Exposure in DBA/2J Mice with Low-Responsive Aryl Hydrocarbon Receptors

Merrill, M. L., Kuruvilla, B. S., Pomp, D., Birnbaum, L. S., & Threadgill, D. W. (2009, May 12). Environmental Health Perspectives.

Elucidation of the transcription network governing mammalian sex determination by exploiting strain-specific susceptibility to sex reversal

Genes & Development, 23(21), 2521–2536.

Epidermal Growth Factor Receptor Is Required for Colonic Tumor Promotion by Dietary Fat in the Azoxymethane/Dextran Sulfate Sodium Model: Roles of Transforming Growth Factor- and PTGS2

Dougherty, U., Cerasi, D., Taylor, I., Kocherginsky, M., Tekin, U., Badal, S., … Bissonnette, M. (2009, November 10). Clinical Cancer Research.

Maternal Dioxin Exposure Combined with a Diet High in Fat Increases Mammary Cancer Incidence in Mice

Merrill, M. L., Harper, R., Birnbaum, L. S., Cardiff, R. D., & Threadgill, D. W. (2009, December 9). Environmental Health Perspectives.

Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans

Harrill, A. H., Watkins, P. B., Su, S., Ross, P. K., Harbourt, D. E., Stylianou, I. M., … Threadgill, D. W. (2009, May 5). Genome Research.

Murine models of colorectal cancer

Uronis, J. M., & Threadgill, D. W. (2009, May 1). Mammalian Genome.

Placental and Embryonic Growth Restriction in Mice With Reduced Function Epidermal Growth Factor Receptor Alleles

Dackor, J., Caron, K. M., & Threadgill, D. W. (2009, June 30). Genetics.

Placental overgrowth and fertility defects in mice with a hypermorphic allele of epidermal growth factor receptor

Dackor, J., Li, M., & Threadgill, D. W. (2009, May 22). Mammalian Genome.

Population-Based Discovery of Toxicogenomics Biomarkers for Hepatotoxicity Using a Laboratory Strain Diversity Panel

Harrill, A. H., Ross, P. K., Gatti, D. M., Threadgill, D. W., & Rusyn, I. (2009, May 6). Toxicological Sciences.

Reduced EGFR causes abnormal valvular differentiation leading to calcific aortic stenosis and left ventricular hypertrophy in C57BL/6J but not 129S1/SvImJ mice

American Journal of Physiology-Heart and Circulatory Physiology, 297(1), H65–H75.

The gastrointestinal microbiome: a malleable, third genome of mammals

Carroll, I. M., Threadgill, D. W., & Threadgill, D. S. (2009, July 1). Mammalian Genome.

Tumor-specific apoptosis caused by deletion of the ERBB3 pseudo-kinase in mouse intestinal epithelium

Lee, D., Yu, M., Lee, E., Kim, H., Yang, Y., Kim, K., … Threadgill, D. W. (2009, August 13). Journal of Clinical Investigation.