David Threadgill

Zhang, X., Xiao, G., Johnson, C., Cai, Y., Horowitz, Z. K., Mennicke, C., … Ghashghaei, H. T. (2023). Bulk and mosaic deletions of Egfr reveal regionally defined gliogenesis in the developing mouse forebrain. ISCIENCE, 26(3). https://doi.org/10.1016/j.isci.2023.106242

Rojas, C. M., McGill, M. P., Salvador, A. C., Bautz, D., & Threadgill, D. W. (2021). Epithelial-specific ERBB3 deletion results in a genetic background-dependent increase in intestinal and colon polyps that is mediated by EGFR. PLOS GENETICS, 17(11). https://doi.org/10.1371/journal.pgen.1009931

Garbutt, T. A., Konganti, K., Konneker, T., Hillhouse, A., Phelps, D., Jones, A., … Threadgill, D. W. (2020). Derivation of stable embryonic stem cell-like, but transcriptionally heterogenous, induced pluripotent stem cells from non-permissive mouse strains. MAMMALIAN GENOME, 31(9-12), 263–286. https://doi.org/10.1007/s00335-020-09849-x

Sudweeks, J., Hollingsworth, B., Blondel, D. V., Campbell, K. J., Dhole, S., Eisemann, J. D., … Lloyd, A. L. (2019). Locally Fixed Alleles: A method to localize gene drive to island populations. SCIENTIFIC REPORTS, 9. https://doi.org/10.1038/s41598-019-51994-0

Lewis, L., Borowa-Mazgaj, B., Conti, A., Chappell, G. A., Luo, Y.-S., Bodnar, W., … Rusyn, I. (2019). Population-Based Analysis of DNA Damage and Epigenetic Effects of 1,3-Butadiene in the Mouse. CHEMICAL RESEARCH IN TOXICOLOGY, 32(5), 887–898. https://doi.org/10.1021/acs.chemrestox.9b00035

Luo, Y.-S., Cichocki, J. A., Hsieh, N.-H., Lewis, L., Wright, F. A., Threadgill, D. W., … Rusyn, I. (2019). Using Collaborative Cross Mouse Population to Fill Data Gaps in Risk Assessment: A Case Study of Population-Based Analysis of Toxicokinetics and Kidney Toxicodynamics of Tetrachloroethylene. ENVIRONMENTAL HEALTH PERSPECTIVES, 127(6). https://doi.org/10.1289/EHP5105

Garbutt, T. A., Konneker, T. I., Konganti, K., Hillhouse, A. E., Swift-Haire, F., Jones, A., … Threadgill, D. W. (2018). Permissiveness to form pluripotent stem cells may be an evolutionarily derived characteristic in Mus muscuius. SCIENTIFIC REPORTS, 8. https://doi.org/10.1038/s41598-018-32116-8

Church, R. J., Gatti, D. M., Urban, T. J., Long, N., Yang, Xi, Shi, Q., … Harrill, A. H. (2015). Sensitivity to hepatotoxicity due to epigallocatechin gallate is affected by genetic background in diversity outbred mice. FOOD AND CHEMICAL TOXICOLOGY, 76, 19–26. https://doi.org/10.1016/j.fct.2014.11.008

Scheving, L. A., Zhang, X., Garcia, O. A., Wang, R. F., Stevenson, M. C., Threadgill, D. W., & Russell, W. E. (2014). Epidermal growth factor receptor plays a role in the regulation of liver and plasma lipid levels in adult male mice. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 306(5), G370–G381. https://doi.org/10.1152/ajpgi.00116.2013

LaGier, M. J., & Threadgill, D. S. (2014). Identification and Characterization of an Invasion Antigen B Gene from the Oral Pathogen Campylobacter rectus. INDIAN JOURNAL OF MICROBIOLOGY, 54(1), 33–40. https://doi.org/10.1007/s12088-013-0406-z

Welsh, C. E., Miller, D. R., Manly, K. F., Wang, J., McMillan, L., Morahan, G., … Villena, F. P.-M. (2014, April). Status and access to the Collaborative Cross population (vol 23, pg 706, 2012). MAMMALIAN GENOME, Vol. 25, pp. 192–192. https://doi.org/10.1007/s00335-014-9501-7

Saito, K., Horiuchi, K., Kimura, T., Mizuno, S., Yoda, M., Morioka, H., … Sato, K. (2013). Conditional Inactivation of TNF alpha-Converting Enzyme in Chondrocytes Results in an Elongated Growth Plate and Shorter Long Bones. PLOS ONE, 8(1). https://doi.org/10.1371/journal.pone.0054853

Bautz, D. J., Broman, K. W., & Threadgill, D. W. (2013). Identification of a Novel Polymorphism in X-Linked Sterol-4-Alpha-Carboxylate 3-Dehydrogenase (Nsdhl) Associated with Reduced High-Density Lipoprotein Cholesterol Levels in I/LnJ Mice. G3-GENES GENOMES GENETICS, 3(10), 1819–1825. https://doi.org/10.1534/g3.113.007567

Ferris, M. T., Aylor, D. L., Bottomly, D., Whitmore, A. C., Aicher, L. D., Bell, T. A., … Heise, M. T. (2013). Modeling Host Genetic Regulation of Influenza Pathogenesis in the Collaborative Cross. PLOS PATHOGENS, 9(2). https://doi.org/10.1371/journal.ppat.1003196

DeSimone, M. C., Rathmell, W. K., & Threadgill, D. W. (2013). Pleiotropic Effects of the Trichloroethylene-Associated P81S VHL Mutation on Metabolism, Apoptosis, and ATM-Mediated DNA Damage Response. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 105(18), 1355–1364. https://doi.org/10.1093/jnci/djt226

Neufert, C., Becker, C., Tuereci, O., Waldner, M. J., Backert, I., Floh, K., … Neurath, M. F. (2013). Tumor fibroblast-derived epiregulin promotes growth of colitis-associated neoplasms through ERK. JOURNAL OF CLINICAL INVESTIGATION, 123(4), 1428–1443. https://doi.org/10.1172/jci63748

Phillippi, J., Xie, Y., Miller, D. R., Bell, T. A., Zhang, Z., Lenarcic, A. B., … Frelinger, J. A. (2013). Using the emerging Collaborative Cross to probe the immune system. Genes & Immunity, 15(1), 38–46. https://doi.org/10.1038/gene.2013.59

Mustafi, R., Dougherty, U., Shah, H., Dehghan, H., Gliksberg, A., Wu, J., … Bissonnette, M. (2012). Both stromal cell and colonocyte epidermal growth factor receptors control HCT116 colon cancer cell growth in tumor xenografts. CARCINOGENESIS, 33(10), 1930–1939. https://doi.org/10.1093/carcin/bgs231

Rinella, E. S., Bankaitis, E. D., & Threadgill, D. W. (2012). Dietary calcium supplementation enhances efficacy but also toxicity of EGFR inhibitor therapy for colon cancer. CANCER BIOLOGY & THERAPY, 13(3), 130–137. https://doi.org/10.4161/cbt.13.3.18690

Ardito, C. M., Gruener, B. M., Takeuchi, K. K., Lubeseder-Martellato, C., Teichmann, N., Mazur, P. K., … Siveke, J. T. (2012). EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis. CANCER CELL, 22(3), 304–317. https://doi.org/10.1016/j.ccr.2012.07.024

Rinella, E. S., & Threadgill, D. W. (2012). Efficacy of EGFR Inhibition Is Modulated by Model, Sex, Genetic Background and Diet: Implications for Preclinical Cancer Prevention and Therapy Trials. PLOS ONE, 7(6). https://doi.org/10.1371/journal.pone.0039552

Franzke, C.-W., Cobzaru, C., Triantafyllopoulou, A., Loeffek, S., Horiuchi, K., Threadgill, D. W., … Blobel, C. P. (2012). Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation. JOURNAL OF EXPERIMENTAL MEDICINE, 209(6), 1105–1119. https://doi.org/10.1084/jem.20112258

Bottomly, D., Ferris, M. T., Aicher, L. D., Rosenzweig, E., Whitmore, A., Aylor, D. L., … Heise, M. (2012). Expression quantitative trait loci for extreme host response to influenza a in pre-collaborative cross mice. G3-Genes Genomes Genetics, 2(2), 213–221.

Kelada, S. N. P., Aylor, D. L., Peck, B. C. E., Ryan, J. F., Tavarez, U., Buus, R. J., … Collins, F. S. (2012). Genetic Analysis of Hematological Parameters in Incipient Lines of the Collaborative Cross. G3-GENES GENOMES GENETICS, 2(2), 157–165. https://doi.org/10.1534/g3.111.001776

Crowley, J. J., Kim, Y., Szatkiewicz, J. P., Pratt, A. L., Quackenbush, C. R., Adkins, D. E., … Sullivan, P. F. (2012). Genome-wide association mapping of loci for antipsychotic-induced extrapyramidal symptoms in mice. MAMMALIAN GENOME, 23(5-6), 322–335. https://doi.org/10.1007/s00335-011-9385-8

Eversley, C. D., Yuying, X., Pearsall, R. S., & Threadgill, D. W. (2012). Mapping Six New Susceptibility to Colon Cancer (Scc) Loci Using a Mouse Interspecific Backcross. G3-GENES GENOMES GENETICS, 2(12), 1577–1584. https://doi.org/10.1534/g3.112.002253

Welsh, C. E., Miller, D. R., Manly, K. F., Wang, J., McMillan, L., Morahan, G., … Villena, F. P.-M. (2012). Status and access to the Collaborative Cross population. MAMMALIAN GENOME, 23(9-10), 706–712. https://doi.org/10.1007/s00335-012-9410-6

Threadgill, D. W., & Churchill, G. A. (2012). Ten Years of the Collaborative Cross. G3-GENES GENOMES GENETICS, 2(2), 153–156. https://doi.org/10.1534/g3.111.001891

Mathes, W. F., Aylor, D. L., Miller, D. R., Churchill, G. A., Chesler, E. J., Villena, F. P.-M., … Pomp, D. (2011). Architecture of energy balance traits in emerging lines of the Collaborative Cross. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 300(6), E1124–E1134. https://doi.org/10.1152/ajpendo.00707.2010

Bollee, G., Flamant, M., Schordan, S., Fligny, C., Rumpel, E., Milon, M., … Dussaule, J. C. (2011). Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis. Nature Medicine, 17(10), 1242–1272.

Kim, K., Lee, H., Threadgill, D. W., & Lee, D. (2011). Epiregulin-dependent amphiregulin expression and ERBB2 signaling are involved in luteinizing hormone-induced paracrine signaling pathways in mouse ovary. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 405(2), 319–324. https://doi.org/10.1016/j.bbrc.2011.01.039

Aylor, D. L., Valdar, W., Foulds-Mathes, W., Buus, R. J., Verdugo, R. A., Baric, R. S., … Churchill, G. A. (2011). Genetic analysis of complex traits in the emerging Collaborative Cross. GENOME RESEARCH, 21(8), 1213–1222. https://doi.org/10.1101/gr.111310.110

Bradford, B. U., Lock, E. F., Kosyk, O., Kim, S., Uehara, T., Harbourt, D., … Rusyn, I. (2011). Interstrain Differences in the Liver Effects of Trichloroethylene in a Multistrain Panel of Inbred Mice. TOXICOLOGICAL SCIENCES, 120(1), 206–217. https://doi.org/10.1093/toxsci/kfq362

Gatti, D. M., Lu, L., Williams, R. W., Sun, W., Wright, F. A., Threadgill, D. W., & Rusyn, I. (2011). MicroRNA expression in the livers of inbred mice. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 714(1-2), 126–133. https://doi.org/10.1016/j.mrfmmm.2011.05.007

Threadgill, D. W., Miller, D. R., Churchill, G. A., & Villena, F. P.-M. (2011). The Collaborative Cross: A Recombinant Inbred Mouse Population for the Systems Genetic Era. ILAR JOURNAL, 52(1), 24–31. https://doi.org/10.1093/ilar.52.1.24

Eversley, C. D., Clark, T., Xie, Y., Steigerwalt, J., Bell, T. A., Villena, F. P. M., & Threadgill, D. W. (2010). Genetic mapping and developmental timing of transmission ratio distortion in a mouse interspecific backcross. BMC GENETICS, 11. https://doi.org/10.1186/1471-2156-11-98

La Merrill, M., Harper, R., Birnbaum, L. S., Cardiff, R. D., & Threadgill, D. W. (2010). Maternal Dioxin Exposure Combined with a Diet High in Fat Increases Mammary Cancer Incidence in Mice. ENVIRONMENTAL HEALTH PERSPECTIVES, 118(5), 596–601. https://doi.org/10.1289/ehp.0901047

Rusyn, I., Gatti, D. M., Wiltshire, T., Kleeberger, S. R., & Threadgill, D. W. (2010, September). Toxicogenetics: population-based testing of drug and chemical safety in mouse models (vol 11, pg 1127, 2010). PHARMACOGENOMICS, Vol. 11, pp. 1344–1344. https://doi.org/10.2217/pgs.10.100

Halladay, A. K., Amaral, D., Aschner, M., Bolivar, V. J., Bowman, A., DiCicco-Bloom, E., … Threadgill, D. W. (2009, September). Animal models of autism spectrum disorders: Information for neurotoxicologists. NEUROTOXICOLOGY, Vol. 30, pp. 811–821. https://doi.org/10.1016/j.neuro.2009.07.002

La Merrill, M., Kuruvilla, B. S., Pomp, D., Birnbaum, L. S., & Threadgill, D. W. (2009). Dietary Fat Alters Body Composition, Mammary Development, and Cytochrome P450 Induction after Maternal TCDD Exposure in DBA/2J Mice with Low-Responsive Aryl Hydrocarbon Receptors. ENVIRONMENTAL HEALTH PERSPECTIVES, 117(9), 1414–1419. https://doi.org/10.1289/ehp.0800530

Munger, S. C., Aylor, D. L., Syed, H. A., Magwene, P. M., Threadgill, D. W., & Capel, B. (2009). Elucidation of the transcription network governing mammalian sex determination by exploiting strain-specific susceptibility to sex reversal. GENES & DEVELOPMENT, 23(21), 2521–2536. https://doi.org/10.1101/gad.1835809

Dougherty, U., Cerasi, D., Taylor, I., Kocherginsky, M., Tekin, U., Badal, S., … Bissonnette, M. (2009). Epidermal Growth Factor Receptor Is Required for Colonic Tumor Promotion by Dietary Fat in the Azoxymethane/Dextran Sulfate Sodium Model: Roles of Transforming Growth Factor-alpha and PTGS2. CLINICAL CANCER RESEARCH, 15(22), 6780–6789. https://doi.org/10.1158/1078-0432.CCR-09-1678

Harrill, A. H., Watkins, P. B., Su, S., Ross, P. K., Harbourt, D. E., Stylianou, I. M., … Threadgill, D. W. (2009). Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans. GENOME RESEARCH, 19(9), 1507–1515. https://doi.org/10.1101/gr.090241.108

Uronis, J. M., & Threadgill, D. W. (2009). [Review of Murine models of colorectal cancer]. MAMMALIAN GENOME, 20(5), 261–268. https://doi.org/10.1007/s00335-009-9186-5

Dackor, J., Caron, K. M., & Threadgill, D. W. (2009). Placental and Embryonic Growth Restriction in Mice With Reduced Function Epidermal Growth Factor Receptor Alleles. GENETICS, 183(1), 207–218. https://doi.org/10.1534/genetics.109.104372

Dackor, J., Li, M., & Threadgill, D. W. (2009). Placental overgrowth and fertility defects in mice with a hypermorphic allele of epidermal growth factor receptor. MAMMALIAN GENOME, 20(6), 339–349. https://doi.org/10.1007/s00335-009-9189-2

Harrill, A. H., Ross, P. K., Gatti, D. M., Threadgill, D. W., & Rusyn, I. (2009). Population-Based Discovery of Toxicogenomics Biomarkers for Hepatotoxicity Using a Laboratory Strain Diversity Panel. TOXICOLOGICAL SCIENCES, 110(1), 235–243. https://doi.org/10.1093/toxsci/kfp096

Barrick, C. J., Roberts, R. B., Rojas, M., Rajamannan, N. M., Suitt, C. B., O'Brien, K. D., … Threadgill, D. W. (2009). Reduced EGFR causes abnormal valvular differentiation leading to calcific aortic stenosis and left ventricular hypertrophy in C57BL/6J but not 129S1/SvImJ mice. American Journal of Physiology-Heart and Circulatory Physiology, 297(1), H65–H75. https://doi.org/10.1152/ajpheart.00866.2008

Carroll, I. M., Threadgill, D. W., & Threadgill, D. S. (2009). [Review of The gastrointestinal microbiome: a malleable, third genome of mammals]. MAMMALIAN GENOME, 20(7), 395–403. https://doi.org/10.1007/s00335-009-9204-7

Lee, D., Yu, M., Lee, E., Kim, H., Yang, Y., Kim, K., … Threadgill, D. W. (2009). Tumor-specific apoptosis caused by deletion of the ERBB3 pseudo-kinase in mouse intestinal epithelium. JOURNAL OF CLINICAL INVESTIGATION, 119(9), 2702–2713. https://doi.org/10.1172/JCI36435