Works (107)

Updated: May 2nd, 2024 05:03

2024 article

HPLC-qTOF-MS/MS Based Profiling Reveals Anthocyanin Profile Alterations in Berries of Hybrid Muscadine Variety FLH 13-11 in Two Continuous Cropping Seasons

YUZUAK, S., Ballington, J., Li, G., & Xie, D. (2024, February 2).

By: S. Yuzuak, J. Ballington, G. Li & D. Xie*

Source: ORCID
Added: February 2, 2024

2024 journal article

High-Performance Liquid Chromatography-Quadrupole Time-of-Flight Tandem Mass Spectrometry-Based Profiling Reveals Anthocyanin Profile Alterations in Berries of Hybrid Muscadine Variety FLH 13-11 in Two Continuous Cropping Seasons

AGRONOMY-BASEL, 14(3).

By: S. Yuzuak n, J. Ballington n, G. Li n & D. Xie n

author keywords: anthocyanidins; anthocyanidin-3,5-O-diglucoside; anthocyanidin-3,5-O-monoglucoside; anthocyanins; HPLC-quadrupole time-of-flight tandem mass spectrometer; Vitis rotundifolia; metabolic profiling
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 1, 2024

2024 journal article

Incorporation of Three Different Optical Trains into the IR-MALDESI Mass Spectrometry Imaging Platform to Characterize Artemisia annua

Journal of the American Society for Mass Spectrometry.

By: S. Ashbacher n, Q. Mills n, A. Sohn n, D. Xie n & D. Muddiman n

Source: ORCID
Added: May 1, 2024

2024 article

Removal of the C4-domain preserves the drought tolerance enhanced by CsMYB4a and eliminates the negative impact of this transcription factor on plant growth

Li, M., Ma, G., Li, X., Guo, L., Li, Y., Liu, Y., … Xia, T. (2024, March 28). ABIOTECH, Vol. 3.

By: M. Li*, G. Ma*, X. Li*, L. Guo*, Y. Li*, Y. Liu*, W. Wang*, X. Jiang* ...

author keywords: Tea; MYB4 repressor; Development; Carbohydrate metabolism; Drought stress; C4-domain
Sources: Web Of Science, NC State University Libraries
Added: April 8, 2024

2023 journal article

A telomere-to-telomere reference genome provides genetic insight into the pentacyclic triterpenoid biosynthesis in Chaenomeles speciosa

HORTICULTURE RESEARCH, 10(10).

By: S. He*, D. Weng, Y. Zhang*, Q. Kong*, K. Wang*, N. Jing*, F. Li*, Y. Ge* ...

TL;DR: The use of an integrative approach involving PacBio HiFi (third-generation) sequencing and Hi-C scaffolding to assemble a high-quality telomere-to-telomere genome of C. speciosa not only provides a valuable resource to enhance understanding of the biosynthesis of medicinal compounds in tissues, but also promotesUnderstanding of the evolution of the Rosaceae. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: November 20, 2023

2023 journal article

Anti-COVID-19 Pandemic Effect of Plant Flavonoids: Use of Green Tea Flavonoids

Journal of Jishou University (NaturalSciencesEdition).

By: X. De Yu, S. Yuzuak & Q. Peng

Contributors: X. De Yu, X. De Yu, X. De Yu, S. Yuzuak, Y. Zhu & Q. Peng

Ed(s): X. De Yu

Source: ORCID
Added: January 29, 2024

2023 article

Exploring the Prebiotic Activities of Proanthocyanidins on a Platform Using the Three-Dimensionally (3D)-Cultured Organoids

Xi, L., Wang, F., Cagle, D., Zhu, Y., Odle, J., & Xie, D. (2023, November 6). JOURNAL OF ANIMAL SCIENCE, Vol. 101, pp. 355–356.

By: L. Xi n, F. Wang n, D. Cagle n, Y. Zhu n, J. Odle n & D. Xie n

author keywords: antibiotics; Interleukins; organoids
TL;DR: It is concluded that epigallocatechin gallate is a potential PA monomer with all prebiotic characteristics and its applicable values in feedstuff and food supply should be studied in vivo studies in domestic (food) animals with and without antigen challenges. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: December 11, 2023

2023 chapter

HPLC-MS<sup>(n)</sup> Applications in the Analysis of Anthocyanins in Fruits

In High Performance Liquid Chromatography - Recent Advances and Applications.

By: S. Yuzuak*, Q. Ma*, Y. Lu & D. Xie n

Source: ORCID
Added: January 29, 2024

2023 journal article

Identification and biosynthesis of plant papanridins, a group of novel oligomeric flavonoids

MOLECULAR PLANT, 16(11), 1773–1793.

By: Y. Zhu n, S. Yuzuak n, X. Sun n & D. Xie n

author keywords: flavanol polymerase; papanridin; flavan-3-ol; flav-2-en-3-ol; flavan-; flaven
TL;DR: A new polymerization pathway of a group of novel oligomeric flavonoids in plants is reported, termed 'papanridins', which will drive further investigations across plant science, nutrition, and animal sciences, seeking to unravel the significance of papanridin in both plants and food products. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: December 18, 2023

2023 journal article

Metabolic engineering of the anthocyanin biosynthetic pathway in Artemisia annua and relation to the expression of the artemisinin biosynthetic pathway

PLANTA, 257(3).

By: R. Judd n, Y. Dong n, X. Sun n, Y. Zhu n, M. Li n & D. Xie n

author keywords: Anthocyanin; Artemisinin; Artemisinic acid; Arteannuin b; Artemisia annua; Plant tissue culture
MeSH headings : Artemisia annua / chemistry; Anthocyanins / metabolism; Biosynthetic Pathways; Metabolic Engineering; Reactive Oxygen Species / metabolism; Tandem Mass Spectrometry; Artemisinins / chemistry; Artemisinins / metabolism
TL;DR: The engineering of anthocyanins does not eliminate the biosynthesis of artemisinin in cells and a new hypothesis that enzymes catalyze the formation of art Artemisinin from dihydroartemisinic acid in non-GT cells is proposed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 24, 2023

2023 journal article

Molecular understanding of anthocyanin biosynthesis activated by PAP1 and regulated by 2, 4-dichlorophenoxyacetic acid in engineered red <i>Artemisia annua</i> cells

PLANTA, 258(4).

By: Y. Dong n, M. Li n, B. Cruz n, E. Ye n, Y. Zhu n, L. Li*, Z. Xu*, D. Xie n

author keywords: Anthocyanin biosynthesis; Auxins; MBW complex; Metabolic engineering; pap1-D; PAP1; 2,4-D
TL;DR: To understand how 2,4-dichlorophenoxyacetic acid, an auxin, regulates the PAP1-activated anthocyanin biosynthesis, five different concentrations were tested and showed that the five concentrations reduced the expression levels of the constitutive P AP1 transgene and three pathway genes significantly and eliminated the expression of the chalcone synthase gene either significantly or slightly. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science, NC State University Libraries
Added: September 6, 2023

2023 article

Molecular understanding of anthocyanin biosynthesis activated by PAP1 in engineered redArtemisia annuacells and regulation of 2, 4-dichlorophenoxyacetic acid

Dong, Y., Li, M., Cruz, B., Ye, E., Zhu, Y., Li, L., … Xie, D.-Y. (2023, March 20).

By: Y. Dong n, M. Li n, B. Cruz n, E. Ye n, Y. Zhu n, L. Li*, Z. Xu*, D. Xie*

TL;DR: To understand how 2,4-dichlorophenoxyacetic acid, an auxin, regulates the PAP1-activated anthocyanin biosynthesis, five different concentrations were tested and showed that the concentrations tested decreased the fresh weight of callus growth, anthocianin levels, and the production of Anthocyanins per petri dish. (via Semantic Scholar)
Source: ORCID
Added: March 21, 2023

2023 article

Unrelated to phenylalanine: Feeding studies provide new insight into salicylic acid biosynthesis

Tan, J., He, P., & Xie, D.-Y. (2023, April). JOURNAL OF INTEGRATIVE PLANT BIOLOGY, Vol. 65, pp. 879–880.

By: J. Tan*, P. He* & D. Xie n

MeSH headings : Phenylalanine; Plant Proteins; Phenylalanine Ammonia-Lyase; Salicylic Acid
TL;DR: In Arabidopsis thaliana, about 90% of SA biosynthesis induced by pathogens or ultraviolet light is produced through the IC pathway and the remaining 10% is thought to beproduced through the PAL pathway. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: May 1, 2023

2022 journal article

<p>Flavonols and dihydroflavonols inhibit the main protease activity of SARS-CoV-2 and the replication of human coronavirus 229E</p>

VIROLOGY, 571, 21–33.

By: Y. Zhu n, F. Scholle n, S. Kisthardt n & D. Xie n

author keywords: (+)-dihydrokaempferol; <p>(+)-dihydroquercetin (taxifolin)</p>; (+)-dihydromyricetin; Kaempferol; Quercetin; Myricentin; Isoquercitrin; Rutin; Flavan-3-ols
MeSH headings : COVID-19; Coronavirus 229E, Human / drug effects; Coronavirus 229E, Human / physiology; Coronavirus 3C Proteases / antagonists & inhibitors; Flavonols / pharmacology; Humans; Molecular Docking Simulation; SARS-CoV-2 / drug effects; Virus Replication / drug effects
TL;DR: In vitro inhibition assays showed that seven available compounds effectively inhibited the SARS-CoV-2 Mpro activity and their IC50 values ranged from 0.125 to 12.9 µM, which indicates that these antioxidative flavonols and dihydroflavonols are promising candidates for curbing the two viruses. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 23, 2022

2022 journal article

A de novo regulation design shows an effectiveness in altering plant secondary metabolism

JOURNAL OF ADVANCED RESEARCH, 37, 43–60.

By: M. Li n, X. He n, C. La Hovary n, Y. Zhu n, Y. Dong n, S. Liu n, H. Xing n, Y. Liu n ...

author keywords: Arabidopsis; Alkaloid; Anthocyanin; Molecular tools; Tobacco; Transcription factor
MeSH headings : Arabidopsis / genetics; Arabidopsis Proteins / genetics; Arabidopsis Proteins / metabolism; Gene Expression Regulation, Plant; Nicotine / metabolism; Pancreatitis-Associated Proteins / genetics; Pancreatitis-Associated Proteins / metabolism; Secondary Metabolism / genetics
TL;DR: G-boxes, MREs, and two TF types are appropriate molecular tools for a De Novo regulation design to create a novel distant-pathway cross regulation for altering plant secondary metabolism. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science
Added: January 26, 2022

2022 article

Alternative splicing of CsJAZ1 negatively regulates flavan-3-ol biosynthesis in tea plants

Zhu, J., Yan, X., Liu, S., Xia, X., An, Y., Xu, Q., … Wei, C. (2022, March 4). PLANT JOURNAL, Vol. 1.

By: J. Zhu*, X. Yan*, S. Liu*, X. Xia*, Y. An*, Q. Xu*, S. Zhao*, L. Liu* ...

author keywords: alternative splicing; JASMONATE ZIM-domain (JAZ) protein; flavan-3-ols; jasmonic acid; MYC2 transcription factor; protein-protein interaction; Camellia sinensis
MeSH headings : Alternative Splicing / genetics; Camellia sinensis / genetics; Camellia sinensis / metabolism; Flavonoids / metabolism; Gene Expression Regulation, Plant / genetics; Tea / metabolism
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: January 26, 2022

2022 journal article

Anthocyanins from muscadine (Vitis rotundifolia) grape fruit

CURRENT PLANT BIOLOGY, 30.

By: S. Yuzuak n & D. Xie n

author keywords: Vitis rotundifolia; Muscadine; Grape; Polyphenols; Anthocyanins; Cyanin; Delphinin; Pelargonin
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 16, 2022

2022 article

Insights into acylation mechanisms: co-expression of serine carboxypeptidase-like acyltransferases and their non-catalytic companion paralogs

Yao, S., Liu, Y., Zhuang, J., Zhao, Y., Dai, X., Jiang, C., … Xia, T. (2022, May 7). PLANT JOURNAL, Vol. 5.

By: S. Yao*, Y. Liu*, J. Zhuang*, Y. Zhao*, X. Dai*, C. Jiang*, Z. Wang*, X. Jiang* ...

author keywords: tea; serine carboxypeptidase-like acyltransferase; flavan-3-ol gallates; co-expression; galloylation; non-catalytic companion paralog
MeSH headings : Acylation; Acyltransferases / metabolism; Carboxypeptidases / genetics; Carboxypeptidases / metabolism; Diospyros; Flavonoids; Phylogeny; Plants / metabolism; Polyphenols; Vitis / metabolism
TL;DR: Findings show that the co‐expression of SCPL‐ATs and their NCCPs contributes to the acylation of flavan‐3‐ols in the plant kingdom. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: May 16, 2022

2022 article

Molecular and biochemical characterization of two 4-coumarate: CoA ligase genes in tea plant (Camellia sinensis)

Li, M., Guo, L., Wang, Y., Li, Y., Jiang, X., Liu, Y., … Xia, T. (2022, May 12). PLANT MOLECULAR BIOLOGY, Vol. 109.

author keywords: 4-Coumaric acid; CoA ligase; Flavonoids; Lignin; Metabolic engineering of phenylpropanoid; Stress
MeSH headings : Camellia sinensis / metabolism; Coenzyme A / genetics; Coenzyme A / metabolism; Coenzyme A Ligases / genetics; Coenzyme A Ligases / metabolism; Flavonoids / genetics; Gene Expression Regulation, Plant; Kinetics; Lignin / metabolism; Plant Proteins / genetics; Plant Proteins / metabolism; Tea
TL;DR: Two 4-coumarate: CoA ligase genes in tea plant involved in phenylpropanoids biosynthesis and response to environmental stresses are reported, indicating the differences of Cs4CL1 and Cs 4CL2 in the phenyl Propanoid metabolism. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: May 13, 2022

2022 journal article

Transcriptional and Metabolic Characterization of Feeding Ramie Growth Enhanced by a Combined Application of Gibberellin and Ethrel

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(19).

By: H. Jie*, Y. Ma*, D. Xie n & Y. Jie*

author keywords: GA(3); ETH; transcriptomics; metabolomics; secondary metabolites
MeSH headings : Boehmeria / metabolism; Chromatography, Liquid; Coenzyme A / metabolism; Ethylenes; Flavonoids; Gene Expression Regulation, Plant; Gibberellins / pharmacology; Hormones; Ligases / metabolism; Lignin / metabolism; Organophosphorus Compounds; Plant Growth Regulators / pharmacology; Plants / metabolism; Tandem Mass Spectrometry; Trans-Cinnamate 4-Monooxygenase / genetics; Trans-Cinnamate 4-Monooxygenase / metabolism; Transferases / metabolism
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: October 11, 2022

2021 article

Flavonols and dihydroflavonols inhibit the main protease activity of SARS-CoV-2 and the replication of human coronavirus 229E

Zhu, Y., Scholle, F., Kisthardt, S. C., & Xie, D.-Y. (2021, July 2). [], Vol. 7.

By: Y. Zhu n, F. Scholle n, S. Kisthardt n & D. Xie n

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: January 26, 2022

2021 article

Molecular and Biochemical Characterization of Two 4-Coumarate: Coa Ligase Genes in Tea Plant (Camellia Sinensis)

Li, M., Guo, L., Wang, Y., Li, Y., Jiang, X., Liu, Y., … Xia, T. (2021, September 21).

TL;DR: Two 4-coumarate: CoA ligase genes in tea plant involved in phenylpropanoids biosynthesis and response to environmental stresses are reported, indicating the differences of Cs4CL1 and Cs 4CL2 in the phenyl Propanoid metabolism. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: September 22, 2021

2020 journal article

Comparative transcriptomics of stem bark reveals genes associated with bast fiber development in Boehmeria nivea L. gaud (ramie)

BMC GENOMICS, 21(1).

By: J. Xie*, J. Li*, Y. Jie*, D. Xie n, D. Yang*, H. Shi*, Y. Zhong*

author keywords: Ramie; Bast fiber; Phloem; Transcriptome
MeSH headings : Boehmeria / physiology; Computational Biology / methods; Gene Expression Profiling; Gene Expression Regulation, Plant; Gene Ontology; Molecular Sequence Annotation; Phloem / genetics; Plant Bark / genetics; Plant Development / genetics; Quantitative Trait, Heritable; Transcriptome
TL;DR: Both morphological study and gene expression analysis supported a burst of phloem and vascular developmental processes during the fiber maturation in the ramie stem, and ethylene and gibberellin are likely to be involved in this process. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: March 10, 2020

2020 journal article

Discovery and characterization of tannase genes in plants: roles in hydrolysis of tannins

NEW PHYTOLOGIST, 226(4), 1104–1116.

By: X. Dai*, Y. Liu*, J. Zhuang*, S. Yao*, L. Liu, X. Jiang*, K. Zhou*, Y. Wang* ...

author keywords: biochemical analysis; galloylated catechins; phylogenetic origin; plant kingdom; tannase; tannins
MeSH headings : Carboxylic Ester Hydrolases / genetics; Crops, Agricultural / enzymology; Fragaria / enzymology; Hydrolysis; Phylogeny; Plant Proteins; Tannins
TL;DR: Plant TA is discovered for the first time in the plant kingdom and is shown to be valuable to improve tannin compositions in plants. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 2, 2020

2020 journal article

Docking Characterization and in vitro Inhibitory Activity of Flavan-3-ols and Dimeric Proanthocyanidins Against the Main Protease Activity of SARS-Cov-2

Frontiers in Plant Science, 11.

By: Y. Zhu n & D. Xie n

author keywords: flavan-3-ols; flavan-3-ol gallates; procyanidins; COVID-19; green tea; muscadine grape; cacao; dark chocolate
TL;DR: The findings indicate that on the one hand, the structural features of flavan-3-ols are closely associated with the affinity scores; on the otherhand, the galloylation and oligomeric types of flavours are critical in creating the inhibitory activity against the Mpro activity. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: December 1, 2020

2020 journal article

Functional demonstration of plant flavonoid carbocations proposed to be involved in the biosynthesis of proanthocyanidins

PLANT JOURNAL, 101(1), 18–36.

By: P. Wang*, Y. Liu*, L. Zhang*, W. Wang*, H. Hou*, Y. Zhao*, X. Jiang*, J. Yu* ...

author keywords: plant flavonoid carbocation; epicatechin carbocation; catechin carbocation; (-)-epicatechin; proanthocyanidins
MeSH headings : Camellia sinensis / genetics; Camellia sinensis / metabolism; Flavonoids / metabolism; Gene Expression Regulation, Plant / genetics; Gene Expression Regulation, Plant / physiology; NADH, NADPH Oxidoreductases / genetics; NADH, NADPH Oxidoreductases / metabolism; Plant Proteins / genetics; Plant Proteins / metabolism; Proanthocyanidins / biosynthesis
TL;DR: The use of an integrative strategy including enzymatic assays, mutant analysis, metabolic engineering, isotope labeling, and metabolic profiling to capture and demonstrate PFCs indicate that flavan-3-ol carbocations exist in extracts and are involved in the biosynthesis of PAs of plants. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 13, 2020

2020 journal article

RNA-seq of aboveground sporophyte's transcriptome of Huperzia serrata and transcriptional understanding of early steps associated with huperzine biosynthesis in forest

CURRENT PLANT BIOLOGY, 24.

By: Q. Peng*, H. Long, C. Du*, J. Li* & D. Xie n

author keywords: Huperssia serrata; Huperzine; RNA-seq; Transcriptome; Forest
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 25, 2021

2019 journal article

A polyketide synthase gene cluster associated with the sexual reproductive cycle of the banana pathogen, Pseudocercospora fijiensis

PLOS ONE, 14(7), e0220319.

By: R. Noar n, E. Thomas n, D. Xie n, M. Carter n, D. Ma n & M. Daub n

Ed(s): O. Lespinet

MeSH headings : Ascomycota / enzymology; Ascomycota / genetics; Ascomycota / pathogenicity; Ascomycota / physiology; Fungal Proteins / genetics; Multigene Family; Musa / microbiology; Neurospora crassa / enzymology; Neurospora crassa / genetics; Phylogeny; Plant Diseases / genetics; Plant Diseases / microbiology; Plant Leaves / microbiology; Polyketide Synthases / genetics; Reproduction / genetics; Sequence Homology; Sordariales / enzymology; Sordariales / genetics
TL;DR: This is the first report of a polyketide synthase pathway associated with spermagonia associated with P. fijiensis, and it is shown that PKS8-4 is more similar than Hybrid8-3 to PKS4. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: September 30, 2019

2019 journal article

Artemisinin Biosynthesis in Non-glandular Trichome Cells of Artemisia annua

Molecular Plant, 12(5), 704–714.

By: R. Judd n, M. Bagley n, M. Li n, Y. Zhu n, C. Lei n, S. Yuzuak n, M. Ekelöf n, G. Pu n ...

author keywords: Artemisia annua; artemisinin; glandular trichome; non-glandular trichome cell
MeSH headings : Artemisia annua / cytology; Artemisia annua / genetics; Artemisia annua / metabolism; Artemisia annua / physiology; Artemisinins / metabolism; Metabolic Engineering; Mutation; Pollination; Trichomes / metabolism
TL;DR: It is reported that non-GT cells of self-pollinated inbred A. annua plants can express the artemisinin biosynthetic pathway and leaves of regenerated gl plantlets biosynthesize artemis inin. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries
Added: February 24, 2020

2019 journal article

Creation of elite growth and development features in PAP1-programmed red Nicotiana tabacum Xanthi via overexpression of synthetic geranyl pyrophosphate synthase genes

Molecular Breeding, 39(4).

By: G. Li n, X. Ji n, J. Xi n, D. Xie n & X. Su*

author keywords: Synthetic geranyl pyrophosphate synthase; Plant synthetic biology; Production of anthocyanin pigment 1; Nicotiana tabacum; Plant biomass; Metabolic engineering
TL;DR: This study indicates that a simultaneous enhancement of plant anthocyanin and terpenoid pathways creates novel elite PAP1-programmed plant varieties. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: April 22, 2019

2019 journal article

Functional characterization of Terminal Flower1 homolog in Cornus canadensis by genetic transformation

Plant Cell Reports, 38(3), 333–343.

By: X. Liu n, J. Zhang n, D. Xie n, R. Franks n & Q. Xiang n

author keywords: Cornus canadensis; CorcanTFL1; Genetic transformation; Inflorescence development; Organ conversion
MeSH headings : Cornus / genetics; Cornus / metabolism; Gene Expression Regulation, Plant / genetics; Gene Expression Regulation, Plant / physiology; Inflorescence / genetics; Inflorescence / metabolism; Phylogeny; Plant Proteins / genetics; Plant Proteins / metabolism
TL;DR: Observations support an important role of CorcanTFL1 in determining flowering time and the morphological destinies of leaves and buds at the node bearing the inflorescence in Cornus canadensis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Sources: Crossref, NC State University Libraries, ORCID
Added: January 23, 2019

2019 journal article

Untargeted Metabolomics of Nicotiana tabacum Grown in United States and India Characterizes the Association of Plant Metabolomes With Natural Climate and Geography

Frontiers in Plant Science, 10.

By: D. Ma n, S. Gandra*, R. Manoharlal*, C. La Hovary n & D. Xie n

author keywords: climate change; continent; geography; metabolomics; nicotine; tobacco; non-polar metabolite; polar metabolite
TL;DR: Comparison revealed that nicotine levels were affected by weather conditions, nevertheless, its trend in leaves was independent of two geographical locations and weather changes, suggesting that climate and geographical variation significantly differentiated the tobacco metabolism. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
13. Climate Action (Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: November 25, 2019

2018 journal article

Cloning and characterization of a monoterpene synthase gene from flowers of Camelina sativa

PLANTA, 247(2), 443–457.

By: M. Borghi n & D. Xie n

author keywords: Terpene Synthase; Flower; Terpenoids; Volatile Organic Compounds; Camelina
MeSH headings : Alkyl and Aryl Transferases / genetics; Alkyl and Aryl Transferases / metabolism; Camellia / enzymology; Camellia / genetics; Flowers / enzymology; Flowers / genetics; Genes, Reporter; Monoterpenes / metabolism; Plant Proteins / genetics; Plant Proteins / metabolism; Plastids / metabolism; Protein Transport; Volatile Organic Compounds / metabolism
TL;DR: The CsTPS1 gene belongs to a mid-size family of 60 genes putatively codifying for TPS enzymes, which suggests that Camelina has the structural framework for the production of terpenes and other secondary metabolites of relevance for the consumers. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 article

Cloning and characterization of a monoterpene synthase gene from flowers of Camelina sativa (vol 247, pg 443, 2018)

Borghi, M., & Xie, D.-Y. (2018, January). PLANTA, Vol. 247, pp. 287–288.

By: M. Borghi n & D. Xie n

Sources: Web Of Science, NC State University Libraries
Added: April 9, 2019

2018 journal article

Evaluation of Digital Image Recognition Methods for Mass Spectrometry Imaging Data Analysis

Journal of The American Society for Mass Spectrometry, 29(12), 2467–2470.

By: M. Ekelöf n, K. Garrard n, R. Judd n, E. Rosen*, D. Xie n, A. Kashuba*, D. Muddiman n

author keywords: Mass spectrometry imaging; Image recognition; SSIM
MeSH headings : Algorithms; Animals; Image Processing, Computer-Assisted / methods; Lymph Nodes / chemistry; Lymph Nodes / metabolism; Macaca mulatta; Maraviroc / pharmacokinetics; Mass Spectrometry / methods; Models, Theoretical; Molecular Imaging / methods; Plant Leaves / chemistry; Tissue Distribution
TL;DR: A method for comprehensive, semi-targeted discovery of molecular distributions of interest from mass spectrometry imaging data, using widely available image similarity scoring algorithms to rank images by spatial correlation is presented. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: December 10, 2018

2018 journal article

HPLC-qTOE-MS/MS-Based Profiling of Flavan-3-ols and Dimeric Proanthocyanidins in Berries of Two Muscadine Grape Hybrids FLH 13-11 and FLH 17-66

METABOLITES, 8(4).

By: S. Yuzuak n, J. Ballington n & D. Xie n

author keywords: muscadine; proanthocyanidins; tandem mass spectrometry
TL;DR: Comparison profiling analysis showed obvious effects of each cultivar on the composition these 30 metabolites, indicating that genotypes control biosynthesis. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 14, 2019

2018 journal article

Molecular Cloning and Functional Characterization of a Dihydroflavonol 4-Reductase from Vitis bellula

MOLECULES, 23(4).

By: Y. Zhu n, Q. Peng*, K. Li* & D. Xie n

author keywords: Vitis bellula; dihydroflavonol reductase; dihydroflavonol; leucoanthocyanidin; anthocyanin; proanthocyanidin
MeSH headings : Alcohol Oxidoreductases / genetics; Alcohol Oxidoreductases / metabolism; Amino Acid Sequence; Cloning, Molecular / methods; Flavonoids / chemistry; Gene Expression Regulation, Enzymologic / drug effects; Gene Expression Regulation, Plant; Open Reading Frames; Plant Proteins / genetics; Plant Proteins / metabolism; Proanthocyanidins / metabolism; Quercetin / analogs & derivatives; Quercetin / chemistry; Vitis / enzymology; Vitis / genetics
TL;DR: Cl cloning and functional characterization of a cDNA encoding a V. bellula dihydroflavonol reductase (VbDFR) involved in the biosynthesis of anthocyanins and proanthocyanidins and demonstrated that the overexpression of V bDFR produced new tobacco anthocianidins. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2018 journal article

Non-plastidial expression of a synthetic insect geranyl pyrophosphate synthase effectively increases tobacco plant biomass

JOURNAL OF PLANT PHYSIOLOGY, 221, 144–155.

By: G. Li n, J. Xi n, X. Ji n, M. Li n & D. Xie n

author keywords: Synthetic geranyl pyrophosphate synthase; Plant synthetic biology; Plant biomass; Metabolic engineering
MeSH headings : Biomass; Insect Proteins / genetics; Insect Proteins / metabolism; Plants, Genetically Modified / genetics; Plants, Genetically Modified / growth & development; Plants, Genetically Modified / physiology; Tobacco / genetics; Tobacco / growth & development; Tobacco / physiology
TL;DR: Non-plastidial expression of the novel sMpGPPS-HA was effective for improving tobacco growth and biomass and indicates that research examining different subcellular localizations facilitates a better understanding of in planta functions of proteins encoded by synthetic cDNAs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 journal article

Overexpression of Artemisia annua Cinnamyl Alcohol Dehydrogenase Increases Lignin and Coumarin and Reduces Artemisinin and Other Sesquiterpenes

FRONTIERS IN PLANT SCIENCE, 9.

By: D. Ma n, C. Xu*, F. Alejos-Gonzalez n, H. Wang*, J. Yang*, R. Judd n, D. Xie n

author keywords: Artemisia annua; artemisinin; arteannuin B; cinnamyl alcohol dehydrogenases; coumarin; lignin; sesquiterpenes
TL;DR: The cloning of a cinnamyl alcohol dehydrogenase (AaCAD) from an inbred self-pollinating (SP) A. annua cultivar is described to understand the metabolic control of artemisinin biosynthesis in plants for high production. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Compartmentalized Overexpression of a Synthetic Geranyl Pyrophosphate Synthase and Its Regulation on Plant Growth and Metabolism

In Vitro Cellular & Developmental Biology - Animal, 53(Suppl. 1), 54–55.

By: G. Li, X. Ji, S. Swantko & D. Xie

Source: NC State University Libraries
Added: November 30, 2020

2017 journal article

Functional Characterization of Tea (Camellia sinensis) MYB4a Transcription Factor Using an Integrative Approach

FRONTIERS IN PLANT SCIENCE, 8.

By: M. Li*, Y. Li*, L. Guo*, N. Gong*, Y. Pang*, W. Jiang*, Y. Liu*, X. Jiang* ...

author keywords: tea; Camellia sinensis; R2R3-MYB; transcription factor; phenylpropanoids; shikimate pathway
TL;DR: A tea (Camellia sinensis) MYB4a is characterized to encode a R2R3-MYB transcription factor, which is shown to repressively control the phenylpropanoid and shikimate pathway. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Metabolic Characterization of the Anthocyanidin Reductase Pathway Involved in the Biosynthesis of Flavan-3-ols in Elite Shuchazao Tea (<em>Camellia sinensis</em>) Cultivar in the Field

Molecules, 22(12), 2241.

By: L. Zhao, X. Jiang*, Y. Qian*, P. Wang*, D. Xie n, L. Gao*, T. Xia*

author keywords: anthocyanidin reductase; (+)-catechin; (-)-epicatechin; (-)-epicatechin-gallate; (-)-epigallocatechin; (-)-epigallocatechin-gallate; (+)-gallocatechin
MeSH headings : Anthocyanins / chemistry; Anthocyanins / metabolism; Biosynthetic Pathways; Camellia sinensis / metabolism; Flavonoids / biosynthesis; Flowers / chemistry; Flowers / metabolism; Gene Expression; Oxidation-Reduction; Oxidoreductases / metabolism; Plant Extracts / chemistry; Plant Extracts / metabolism; Plant Leaves / chemistry; Plant Leaves / metabolism; Polyphenols / chemistry; Polyphenols / metabolism
TL;DR: The majority of leaf flavan-3-ols in Shuchazao’s leaves were produced from the ANR pathway, indicating that the two genes in tobacco led to the formation of PAs in flowers and the reduction of anthocyanins. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: ORCID, NC State University Libraries
Added: April 22, 2020

2017 journal article

Metabolic characterization of the anthocyanidin reductase pathway involved in the biosynthesis of flavan-3-ols in Elite Shuchazao Tea (Camellia sinensis) cultivar in the field

Molecules, 22(12).

By: L. Zhao, X. Jiang, Y. Qian, P. Wang, D. Xie, L. Gao, T. Xia

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Metabolic engineering of anthocyanins in dark tobacco varieties

PHYSIOLOGIA PLANTARUM, 159(1), 2–12.

By: X. He n, Y. Li n, D. Lawson* & D. Xie n

MeSH headings : Alcohol Oxidoreductases / genetics; Anthocyanins / metabolism; Arabidopsis Proteins / genetics; Arabidopsis Proteins / metabolism; Carotenoids / metabolism; Chlorophyll / metabolism; Gene Expression Regulation, Plant; Genotype; Metabolic Engineering; Oxygenases / genetics; Pancreatitis-Associated Proteins; Phenotype; Photosynthesis; Pigmentation; Plant Leaves / genetics; Plant Leaves / metabolism; Plant Proteins / genetics; Plants, Genetically Modified; Tobacco / genetics; Tobacco / metabolism; Transcription Factors / genetics; Transcription Factors / metabolism
TL;DR: Analysis of photosynthesis rate, chlorophylls and carotenoids contents showed no differences between red/purple transgenic and control plants, indicating that this metabolic engineering did not alter photosynthetic physiological traits. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Overexpression and Suppression of Artemisia annua 4-Hydroxy-3-Methylbut-2-enyl Diphosphate Reductase 1 Gene (AaHDR1) Differentially Regulate Artemisinin and Terpenoid Biosynthesis

FRONTIERS IN PLANT SCIENCE, 8.

By: D. Ma n, G. Li n, Y. Zhu n & D. Xie n

author keywords: Artemisia annua; artemisinin; arteannuin B; 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase; methylerythritol phosphate pathway; terpene
TL;DR: The overexpression and suppression of AaHDR1 protein level in plastids differentially affect artemisinin and other terpenoid biosynthesis, and alter non-polar metabolite profiles of A. annua. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Overexpression of Populus×canescens isoprene synthase gene in Camelina sativa leads to alterations in its growth and metabolism

Journal of Plant Physiology, 215, 122–131.

author keywords: Camelina; Fast Isoprene Sensor; Isoprene; Terpenoids
MeSH headings : Alkyl and Aryl Transferases / genetics; Alkyl and Aryl Transferases / metabolism; Butadienes / metabolism; Camellia / enzymology; Camellia / growth & development; Camellia / metabolism; Carbon Dioxide / metabolism; Hemiterpenes / metabolism; Pentanes / metabolism; Photosynthesis / genetics; Photosynthesis / physiology; Plant Proteins / genetics; Plant Proteins / metabolism; Populus / enzymology; Populus / growth & development; Populus / metabolism; Terpenes / metabolism
TL;DR: This study characterized isoprene formation following a diurnal/nocturnal cycle in wild-type Camelina plants and suggested that the reduced biomass was likely a trade-off consequence of the increasedIsoprene emission. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: May 8, 2020

2017 journal article

Overexpression of a type-I isopentenyl pyrophosphate isomerase of Artemisia annua in the cytosol leads to high arteannuinB production and artemisinin increase

Plant Journal, 91(3), 466–479.

MeSH headings : Artemisia annua / enzymology; Artemisia annua / genetics; Artemisia annua / metabolism; Artemisinins / metabolism; Carbon-Carbon Double Bond Isomerases / genetics; Carbon-Carbon Double Bond Isomerases / metabolism; Cytosol / enzymology; Cytosol / metabolism; Hemiterpenes; Plant Proteins / genetics; Plant Proteins / metabolism; Plants, Genetically Modified / enzymology; Plants, Genetically Modified / genetics; Plants, Genetically Modified / metabolism
TL;DR: Evidence is provided that overexpression of AaIPPI1 in the cytosol can lead to metabolic alterations of terpenoid biosynthesis, and it is shown that transgenic plants have the potential to yield high production levels of arteannuin B as a new precursor source for artemisinin. (via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2017 journal article

Red and White PAP1-controlled Arabidopsis Cells Are Dependent Upon TT8

In Vitro Cellular & Developmental Biology - Animal, 53(Supplement 1), S51–S51.

By: Y. Zhu & D. Xie

Source: NC State University Libraries
Added: December 4, 2020

2017 journal article

Regulation of Anthocyanin Biosynthesis in the WD40-bHLH-MYB Complex-Programmed Arabidopsis Cells

In Vitro Cellular & Developmental Biology - Animal, 53(Suppl 1), 13–13.

By: D. Xie

Source: NC State University Libraries
Added: November 30, 2020

2016 journal article

Analysis of two TFL1 homologs of dogwood species (Cornus L.) indicates functional conservation in control of transition to flowering

Planta, 243(5), 1129–1141.

By: X. Liu n, J. Zhang*, A. Abuahmad n, R. Franks n, D. Xie n & Q. Xiang n

Contributors: X. Liu n, J. Zhang*, A. Abuahmad n, R. Franks n, D. Xie n & Q. Xiang n

author keywords: Cornus; TERMINAL FLOWER 1 (TFL1); Genetic transformation; Flowering time; Inflorescence architecture
MeSH headings : Arabidopsis / genetics; Arabidopsis Proteins / genetics; Arabidopsis Proteins / metabolism; Cloning, Molecular; Cornus / genetics; Cornus / physiology; Flowers / genetics; Flowers / physiology; Gene Expression Regulation, Plant; Inflorescence / genetics; Mutation; Phylogeny; Plant Proteins / genetics; Plant Proteins / metabolism; Plants, Genetically Modified; Sequence Homology, Amino Acid
TL;DR: The role of TFL1 homologs of Cornus L. canadensis in regulating the transition to reproductive development in Arabidopsis is reported and data indicate that CorfloTFL1 and CorcanTfl1 have conserved the ancestral function of Tfl1 and CEN regulating flowering time and inflorescence determinacy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2016 article

Artemisia annua, artemisinin, and the Nobel Prize: beauty of natural products and educational significance

Xie, D.-Y. (2016, January). SCIENCE BULLETIN, Vol. 61, pp. 42–44.

By: D. Xie n

TL;DR: The 2015 Nobel Prize in Physiology or Medicine was awarded to Professors Youyou Tu, William C.Campbell, and Satoshi Omura for physiology or medicine. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 article

Artemisinin biosynthesis in Artemisia annua and metabolic engineering: questions, challenges, and perspectives

Xie, D.-Y., Ma, D.-M., Judd, R., & Jones, A. L. (2016, December). PHYTOCHEMISTRY REVIEWS, Vol. 15, pp. 1093–1114.

By: D. Xie n, D. Ma n, R. Judd n & A. Jones n

author keywords: Artemisia annua; Artemisinin; Genetics; Malaria; Metabolic profiling; Sesquiterpenoid; Terpenoid
TL;DR: This work focuses on reviewing progresses achieved in understanding biosynthetic pathway, genetic breeding, metabolic engineering, and synthetic biology, and discusses multiple fundamental questions and challenges of artemisinin biosynthesis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2016 journal article

Metabolic Network Based Regulation of Artemisinin Biosynthesis for Anti-malarial Medicine

In Vitro Cellular & Developmental Biology - Plant, 52(Supplement), S24.

By: D. Xie

Source: NC State University Libraries
Added: April 4, 2021

2016 journal article

Ontogenetic characterization of sporangium and spore of Huperzia serrata: an anti-aging disease fern

BOTANICAL STUDIES, 57(1).

By: H. Long, J. Li*, Y. Li*, D. Xie n, Q. Peng* & L. Li*

author keywords: Huperzia serrata; Sporangium; Spore; Ontogenesis
TL;DR: The sporangial development of H. serrata belongs to the eusporangium type, and the development takes approximately 1 year from the initiation to the maturation, useful for improving propagation of this medicinal plant in the future. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2016 journal article

Overexpression of a synthetic insect-plant geranyl pyrophosphate synthase gene in Camelina sativa alters plant growth and terpene biosynthesis

Planta, 244(1), 215–230.

Deyu Xie

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Overexpression of a synthetic insect–plant geranyl pyrophosphate synthase gene in Camelina sativa alters plant growth and terpene biosynthesis

Planta, 244(1), 215–230.

By: J. Xi n, L. Rossi n, X. Lin n & D. Xie n

MeSH headings : Animals; Arabidopsis / genetics; Blotting, Western; Brassinosteroids / pharmacology; Camellia / genetics; Camellia / growth & development; Camellia / metabolism; Dimethylallyltranstransferase / genetics; Dimethylallyltranstransferase / metabolism; Gas Chromatography-Mass Spectrometry; Gene Expression Regulation, Plant / drug effects; Gene Expression Regulation, Plant / genetics; Gibberellins / pharmacology; Humans; Insecta / genetics; Ligases / genetics; Ligases / metabolism; Microscopy, Confocal; Plant Growth Regulators / pharmacology; Plants, Genetically Modified; Plastids / enzymology; Polyisoprenyl Phosphates / metabolism; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Terpenes / metabolism
UN Sustainable Development Goal Categories
Source: Crossref
Added: May 8, 2020

2016 journal article

Salt stress induces differential regulation of the phenylpropanoid pathway in Olea europaea cultivars Frantoio (salt-tolerant) and Leccino (salt-sensitive)

Journal of Plant Physiology, 204, 8–15.

By: L. Rossi n, M. Borghi n, A. Francini*, X. Lin n, D. Xie n & L. Sebastiani*

author keywords: Kaempferol; Gene-expression; Olive tree; Quercetin; Salinity
MeSH headings : Gene Expression Regulation, Plant / drug effects; Genes, Plant; Kaempferols / analysis; Metabolic Networks and Pathways / drug effects; Metabolic Networks and Pathways / genetics; Olea / drug effects; Olea / genetics; Olea / growth & development; Olea / physiology; Organ Specificity / drug effects; Plant Leaves / drug effects; Plant Leaves / metabolism; Plant Roots / drug effects; Plant Roots / metabolism; Plant Stems / drug effects; Plant Stems / metabolism; Propanols / metabolism; Quercetin / analysis; RNA, Messenger / genetics; RNA, Messenger / metabolism; Salt Tolerance / drug effects; Salt Tolerance / genetics; Sodium / metabolism; Sodium Chloride / pharmacology; Stress, Physiological / drug effects; Transcription, Genetic / drug effects
TL;DR: The data suggest that Frantoio copes with the toxicity imposed by elevated sodium not only with mechanisms of Na+ exclusion, but also promptly allocating effective and adequate antioxidant compounds to more sensitive organs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2016 journal article

Tissue-specific production of limonene in Camelina sativa with the Arabidopsis promoters of genes BANYULS and FRUITFULL

PLANTA, 243(2), 549–561.

By: M. Borghi n & D. Xie n

author keywords: BANYULS; FRUITFULL; Camelina; Metabolic engineering; Oilseed crop; Limonene
MeSH headings : Arabidopsis / genetics; Arabidopsis Proteins / genetics; Brassicaceae / genetics; Brassicaceae / metabolism; Citrus / genetics; Cyclohexenes / metabolism; Green Fluorescent Proteins / analysis; Intramolecular Lyases / biosynthesis; Intramolecular Lyases / genetics; Limonene; MADS Domain Proteins / genetics; Metabolic Engineering; NADH, NADPH Oxidoreductases / genetics; Plants, Genetically Modified / metabolism; Seeds / genetics; Seeds / metabolism; Terpenes / metabolism
TL;DR: The results of experiments indicate that AtBANpro and AtFULpro can be successfully utilized to induce the expression of the transgenes of interest in seeds and fruits of Camelina. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

A Genome-Wide Scenario of Terpene Pathways in Self-pollinated Artemisia annua

MOLECULAR PLANT, 8(11), 1580–1598.

By: D. Ma n, Z. Wang n, L. Wang*, F. Alejos-Gonzales n, M. Sun* & D. Xie n

author keywords: Artemisia annua; artemisinin; terpene; metabolic profiling; pyrosequencing
MeSH headings : Artemisia annua / genetics; Artemisia annua / metabolism; Artemisinins / metabolism; Gas Chromatography-Mass Spectrometry; Gene Expression Profiling; Genes, Plant; Metabolomics; Pollination / genetics; Self-Fertilization / genetics; Terpenes / metabolism
TL;DR: An integrated approach combining metabolomics, transcriptomics, and gene function analyses was used to characterize gene-to-terpene and terpene pathway scenarios in a self-pollinating variety of Artemisia annua, identifying 47 genes that mapped to the artemisinin, non-amorphadiene sesquiterpene, monoterpenes, triterpenes and mevalonate pathways. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

A photorespiratory bypass increases plant growth and seed yield in biofuel crop Camelina sativa

BIOTECHNOLOGY FOR BIOFUELS, 8(1).

By: J. Dalal n, H. Lopez n, N. Vasani n, Z. Hu n, J. Swift n, R. Yalamanchili n, M. Dvora n, X. Lin n ...

Contributors: J. Dalal n, H. Lopez n, N. Vasani n, Z. Hu n, J. Swift n, R. Yalamanchili n, M. Dvora n, X. Lin n ...

author keywords: Camelina; Seed yield; Biofuel; Photorespiratory bypass; Photosynthesis
TL;DR: By reducing photorespiratory losses and increasing photosynthetic CO2 fixation rates, transgenic plants show dramatic increases in seed yield, and the bypass approach may have significant impact on increasing agricultural productivity for C3 crops. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2015 journal article

Enhanced diversity and aflatoxigenicity in interspecific hybrids ofAspergillus flavusandAspergillus parasiticus

Molecular Ecology, 24(8), 1889–1909.

By: R. Olarte n, C. Worthington n, B. Horn*, G. Moore*, R. Singh n, J. Monacell n, J. Dorner*, E. Stone n, D. Xie n, I. Carbone n

author keywords: allopolyploid; array comparative genome hybridization; flow cytometry; meiosis; population
MeSH headings : Aflatoxins / biosynthesis; Aspergillus / classification; Aspergillus / genetics; Aspergillus flavus / genetics; Comparative Genomic Hybridization; Genes, Mating Type, Fungal; Genotype; Genotyping Techniques; Hybridization, Genetic; Molecular Sequence Data; Phenotype; Phylogeny; Sequence Analysis, DNA; Sterigmatocystin / analogs & derivatives; Sterigmatocystin / biosynthesis
TL;DR: The results suggest that hybridization is an important diversifying force resulting in the genesis of novel toxin profiles in these agriculturally important fungi. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018

2015 journal article

Functional characterization of an anthocyanidin reductase gene from the fibers of upland cotton (Gossypium hirsutum)

PLANTA, 241(5), 1075–1089.

By: Y. Zhu*, H. Wang*, Q. Peng*, Y. Tang*, G. Xia*, J. Wu*, D. Xie n

author keywords: Gossypium hirsutum; Proanthocyanidins; Anthocyanidin reductase; Flavan-3-ols
MeSH headings : Cloning, Molecular; Genes, Plant; Gossypium / genetics; NADH, NADPH Oxidoreductases / genetics
TL;DR: Virus-induced gene silencing of GhANR11 led to a significant increase in anthocyanins and a decrease in the PAs, (−)-epicatechin, and (−)-catechin in the stems and leaves of VIGS-infected plants. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Biosynthesis and Metabolic Engineering of Anthocyanins in Arabidopsis thaliana

Recent Patents on Biotechnology, 8(1), 47–60.

By: M. Shi n & D. Xie n

MeSH headings : Anthocyanins / biosynthesis; Anthocyanins / chemistry; Arabidopsis / chemistry; Arabidopsis / metabolism; Gene Expression Regulation, Plant; Glycosyltransferases / genetics; Glycosyltransferases / metabolism; Metabolic Engineering; Patents as Topic; Plants, Genetically Modified / metabolism
TL;DR: Current progresses and findings including structural diversity, regulatory properties and metabolic engineering of anthocyanins in Arabidopsis thaliana are discussed. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 13, 2020

2014 journal article

Molecular cloning and functional characterization of the anthocyanidin reductase gene from Vitis bellula

PLANTA, 240(2), 381–398.

By: Y. Zhu*, Q. Peng*, K. Li* & D. Xie n

author keywords: Anthocyanidin reductase; Flavan-3-ols; (-)-Epicatechin; (-)-Catechin; (-)-Epigallocatechin; (-)-Gallocatechin; Proanthocyanidins; Vitis bellula
MeSH headings : Anthocyanins / metabolism; Cloning, Molecular / methods; Hydrogen-Ion Concentration; NADH, NADPH Oxidoreductases / genetics; NADH, NADPH Oxidoreductases / metabolism; Plant Proteins / genetics; Plant Proteins / metabolism; Vitis / enzymology
TL;DR: Cl cloning and functional characterization of an ANR homolog from the leaves of Vitis bellula, a newly developed grape crop in southern China are reported and demonstrate that VbANR forms the ANR pathway, leading to the formation of three types of isomeric flavan-3-ols and PAs in the Leaves of V. bellula. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Regulation of anthocyanin biosynthesis in Arabidopsis thaliana red pap1-D cells metabolically programmed by auxins

PLANTA, 239(4), 765–781.

By: Z. Liu n, M. Shi n & D. Xie n

author keywords: Anthocyanin biosynthesis; Arabidopsis thaliana; Auxins; Metabolic engineering; pap1-D cells; WBM complex; Regulation route
MeSH headings : 2,4-Dichlorophenoxyacetic Acid / pharmacology; Anthocyanins / metabolism; Arabidopsis / drug effects; Arabidopsis / genetics; Arabidopsis / metabolism; Arabidopsis Proteins / genetics; Arabidopsis Proteins / metabolism; Biosynthetic Pathways; Gene Expression Regulation, Plant; Indoleacetic Acids / pharmacology; Light; Metabolic Engineering; Pancreatitis-Associated Proteins; Pigmentation; Plant Growth Regulators / pharmacology; Tissue Culture Techniques; Transcription Factors / genetics; Transcription Factors / metabolism
TL;DR: The data demonstrate that the three auxins regulate anthocyanin biosynthesis in metabolically programmed red cells via altering the expression of transcription factor genes and pathway genes, such as DFR and ANS. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Characterization of Flavan-3-ols and Expression of MYB and Late Pathway Genes Involved in Proanthocyanidin Biosynthesis in Foliage of Vitis bellula

Metabolites, 3(1), 185–203.

By: Y. Zhu*, Q. Peng*, C. Du*, K. Li* & D. Xie n

author keywords: Vitis bellula; proanthocyanidins; anthocyanidin reductase; leucoanthocyanidin reductase; flavan-3-ols
TL;DR: PA formation and characterization of gene expression involved in PA biosynthesis in leaves of V. bellula are reported and it is shown that both ANR and LAR branches are involved in PAs biosynthetic processes of this wild edible grape species. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 13, 2020

2013 journal article

Efficient Somatic Embryogenesis and Organogenesis of Self-Pollination <i>Artemisia annua</i> Progeny and Artemisinin Formation in Regenerated Plants

American Journal of Plant Sciences, 04(11), 2206–2217.

By: F. Alejos-Gonzalez, K. Perkins, M. Winston & D. Xie*

TL;DR: The results show the highly efficient regeneration capacity of self-pollination A. annua plants that can form a new platform to enhance the understanding of artemisinin biosynthesis and metabolic engineering. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: March 20, 2021

2013 journal article

Mechanisms of Metabolic Programming Toward Anthocyanin Biosynthesis in Cultured Red Arabidopsis Cells

In Vitro Cellular & Developmental Biology - Plant, 49(4), 484–485.

By: D. Xie, M. Shi & Z. Liu

Source: NC State University Libraries
Added: April 4, 2021

2013 journal article

Plant regeneration and genetic transformation of C. canadensis: a non-model plant appropriate for investigation of flower development in Cornus (Cornaceae)

Plant Cell Reports, 32(1), 77–87.

By: X. Liu n, C. Feng n, R. Franks n, R. Qu n, D. Xie n & Q. Xiang n

Contributors: X. Liu n, C. Feng n, R. Franks n, R. Qu n, D. Xie n & Q. Xiang n

MeSH headings : Cornus / drug effects; Cornus / genetics; Cornus / growth & development; Flowers / drug effects; Flowers / genetics; Flowers / growth & development; Fluorescence; Gene Expression Regulation, Plant; Green Fluorescent Proteins / metabolism; Hygromycin B / pharmacology; Inflorescence / drug effects; Inflorescence / growth & development; Microscopy, Confocal; Models, Biological; Plant Shoots / drug effects; Plant Shoots / growth & development; Regeneration / drug effects; Reverse Transcriptase Polymerase Chain Reaction; Soil; Transformation, Genetic / drug effects
TL;DR: An effective protocol of plant regeneration and genetic transformation of C. canadensis via Agrobacterium strain EHA105-mediated transformation is reported, providing an appropriate platform to investigate the molecular mechanisms by which the various inflorescence forms are developed in Cornus plants. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science; OpenAlex)
Sources: NC State University Libraries, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2012 journal article

An integrated approach to demonstrating the ANR pathway of proanthocyanidin biosynthesis in plants

PLANTA, 236(3), 901–918.

By: Q. Peng*, Y. Zhu*, Z. Liu n, C. Du*, K. Li* & D. Xie n

author keywords: ANR pathway; Anthocyanidin reductase; Leucoanthocyanidin reductase; Flavan-3-ols; Catechin; Epicatechin; Proanthocyanidins
MeSH headings : Anthocyanins / metabolism; Biosynthetic Pathways; Catechin / metabolism; Dryopteris / metabolism; Flowers / metabolism; Magnoliopsida / metabolism; NADH, NADPH Oxidoreductases / metabolism; Plant Growth Regulators / metabolism; Plant Leaves / metabolism; Proanthocyanidins / biosynthesis; Seeds / metabolism
TL;DR: Results demonstrate that in addition to leaves of M. sativa, tissues of other eight plants contain an active ANR pathway, and a sequence BLAST analysis reveals that ANR homologs have been sequenced in plants from both gymnosperms and angiosperms, and shows that theANR pathway to PA biosynthesis occurs in both seed and seedless vascular plants. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 chapter

Comparative Metabolomics of Transgenic Tobacco Plants (Nicotiana tabacum var. Xanthi) Reveals Differential Effects of Engineered Complete and Incomplete Flavonoid Pathways on the Metabolome

In Y. O. Çiftçi (Ed.), Transgenic Plants - Advances and Limitations.

By: C. Broeckling n, K. Li & D. Xie n

Ed(s): Y. Çiftçi

TL;DR: Biochemical and genetic evidences have demonstrated that anthocyanins and proanthocyanidins share the same upstream pathway beginning with phenylalanine through a series of enzymatic reaction to Anthocyanin reductase, leading to uncertainty about whether or not this branch catalyzed by LAR exists in plants. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: March 20, 2021

2012 journal article

Differentiation of programmed Arabidopsis cells

Bioengineered, 3(1), 54–59.

By: D. Xie n & M. Shi n

author keywords: Arabidopsis thaliana; anthocyanin; PAP1; metabolic; engineering; metabolic fate; plant secondary metabolism
MeSH headings : Anthocyanins / metabolism; Arabidopsis / cytology; Arabidopsis / genetics; Arabidopsis / metabolism; Arabidopsis Proteins / genetics; Arabidopsis Proteins / metabolism; Cell Differentiation / genetics; Cell Differentiation / physiology; Gene Expression Regulation, Plant; Pancreatitis-Associated Proteins; Transcription Factors / genetics; Transcription Factors / metabolism
TL;DR: The potential mechanisms that underlie the programming and reprogramming of gene expression involved in anthocyanin biosynthesis are discussed. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 14, 2020

2012 journal article

Evolution of bract development and B‐class MADS box gene expression in petaloid bracts of Cornus s. l. (Cornaceae)

New Phytologist, 196(2), 631–643.

By: C. Feng n, X. Liu n, Y. Yu n, D. Xie n, R. Franks n & Q. Xiang n

Contributors: C. Feng n, X. Liu n, Y. Yu n, D. Xie n, R. Franks n & Q. Xiang n

author keywords: APETALA3; B-class gene expression; Cornus; development; Evo-Devo; evolution of petaloid bracts; heterotopic petaloidy; PISTILLATA
MeSH headings : Biological Evolution; Cell Shape; Cornaceae / anatomy & histology; Cornaceae / genetics; Cornaceae / growth & development; Cornaceae / ultrastructure; Flowers / cytology; Flowers / genetics; Flowers / growth & development; Flowers / ultrastructure; Gene Expression Regulation, Developmental; Gene Expression Regulation, Plant; Genes, Plant / genetics; Inflorescence / growth & development; MADS Domain Proteins / genetics; MADS Domain Proteins / metabolism; Phylogeny; Plant Epidermis / cytology; Plant Epidermis / ultrastructure; Plant Leaves / cytology; Plant Leaves / genetics; Plant Leaves / growth & development; Plant Leaves / ultrastructure; Plant Proteins / genetics; Plant Proteins / metabolism; Seasons; Time Factors
TL;DR: Phylogeny-based analysis identified developmental and gene expression changes that are correlated with the evolution of petaloid bracts in C. florida and C. canadensis, and it is suggested that functional transference within B-class gene families may have contributed to the origin of bract petaloids in these species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2012 journal article

Integration of GC-MS Based Non-Targeted Metabolic Profiling with Headspace Solid Phase Microextraction Enhances the Understanding of Volatile Differentiation in Tobacco Leaves from North Carolina, India and Brazil

American Journal of Plant Sciences, 03(12), 1759–1769.

By: D. Ma n, S. Gandra*, N. Sharma* & D. Xie n

TL;DR: Gas chromatography-mass spectrometry based non-targeted metabolomics is used to develop appropriate headspace solid phase microextractions (HS-SPME) to enhance the understanding of volatile complexity of flue-cured tobacco leaves. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 21, 2021

2012 conference paper

Programming and reprogramming of gene expression: Mechanisms of cellular specific metabolisms?

Pharmaceutical Biology, 50(11), 1356–1356.

By: D. Xie & M. Shi

Event: 51st Annual Meeting of the Phytochemical Society of North America at University of Western Ontario, London, Ontario, Canada on August 11-15, 2012

Source: NC State University Libraries
Added: April 4, 2021

2012 journal article

Regulation of anthocyanin biosynthesis by nitrogen in TTG1-GL3/TT8-PAP1-programmed red cells of Arabidopsis thaliana

PLANTA, 236(3), 825–837.

By: L. Zhou n, M. Shi n & D. Xie n

author keywords: Arabidopsis thaliana; Anthocyanin biosynthesis; Production of anthocyanin pigmentation 1; Nitrogen
MeSH headings : Anthocyanins / biosynthesis; Arabidopsis / cytology; Arabidopsis / genetics; Arabidopsis / metabolism; Arabidopsis Proteins / metabolism; Basic Helix-Loop-Helix Transcription Factors / metabolism; Biosynthetic Pathways; Gene Expression Regulation, Plant; Genes, Plant; Genetic Variation; Genotype; Nitrogen / metabolism; Pancreatitis-Associated Proteins; Transcription Factors / metabolism
TL;DR: Nitrogen regulation of anthocyanin biosynthesis in red cells undergoes a mechanism by which nitrogen controls the expression of genes encoding both main components of the TTG1–GL3/TT8–PAP1 complex and negative regulators. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

Self-pollinated Artemisia annua plants form a new platform to understand artemisinin biosynthesis

Pharmaceutical Biology, 50(5), 662–662.

By: D. Xie, F. Alejos-Gonzalez & G. Qu

Source: NC State University Libraries
Added: November 24, 2021

2012 article

Special Issue on Metabolic Plant Biology

Xie, D.-Y., & Melis, A. (2012, September). PLANTA, Vol. 236, pp. 763–764.

By: D. Xie n & A. Melis*

MeSH headings : Botany / history; History, 20th Century; History, 21st Century; Plant Physiological Phenomena; Plants / metabolism; United States
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

A Small-Molecule Screen Identifies l-Kynurenine as a Competitive Inhibitor of TAA1/TAR Activity in Ethylene-Directed Auxin Biosynthesis and Root Growth in Arabidopsis

The Plant Cell, 23(11), 3944–3960.

By: W. He*, J. Brumos n, H. Li*, Y. Ji*, M. Ke*, X. Gong*, Q. Zeng*, W. Li* ...

Contributors: W. He*, J. Brumos n, H. Li*, Y. Ji*, M. Ke*, X. Gong*, Q. Zeng*, W. Li*, X. Zhang*, F. An*

MeSH headings : Arabidopsis / drug effects; Arabidopsis / growth & development; Arabidopsis / metabolism; Arabidopsis Proteins / metabolism; Cell Nucleus / metabolism; DNA-Binding Proteins; Enzyme Inhibitors / pharmacology; Ethylenes / metabolism; Ethylenes / pharmacology; F-Box Proteins / metabolism; Indoleacetic Acids / metabolism; Indoleacetic Acids / pharmacology; Kynurenine / chemistry; Kynurenine / metabolism; Kynurenine / pharmacology; Models, Molecular; Nuclear Proteins / metabolism; Plant Roots / drug effects; Plant Roots / growth & development; Plant Roots / metabolism; Small Molecule Libraries; Transcription Factors / metabolism; Tryptophan Transaminase / antagonists & inhibitors; Tryptophan Transaminase / genetics; Tryptophan Transaminase / metabolism
TL;DR: This work identifies a small molecule, l-kynurenine (Kyn), which effectively inhibited ethylene responses in Arabidopsis thaliana root tissues and describes a previously undiscovered positive feedback loop between auxin biosynthesis and ethylene signaling pathways in roots. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Sources: Crossref, NC State University Libraries, Web Of Science, ORCID
Added: August 6, 2018

2011 journal article

Characterization of development and artemisinin biosynthesis in self-pollinated Artemisia annua plants

PLANTA, 234(4), 685–697.

By: F. Alejos-Gonzalez n, G. Qu n, L. Zhou n, C. Saravitz n, J. Shurtleff n & D. Xie n

author keywords: Artemisinin; Artemisia annua; HPLC-MS; Metabolic profiling; Self-pollination; Genetic engineering
MeSH headings : Alkyl and Aryl Transferases / genetics; Antimalarials / isolation & purification; Antimalarials / metabolism; Artemisia annua / anatomy & histology; Artemisia annua / chemistry; Artemisia annua / enzymology; Artemisia annua / physiology; Artemisinins / isolation & purification; Artemisinins / metabolism; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System / genetics; Flowers / anatomy & histology; Flowers / chemistry; Flowers / enzymology; Flowers / physiology; Lactones / isolation & purification; Lactones / metabolism; Plant Leaves / anatomy & histology; Plant Leaves / chemistry; Plant Leaves / enzymology; Plant Leaves / physiology; Plant Proteins / genetics; Plants, Medicinal; Pollination / physiology; Seedlings / anatomy & histology; Seedlings / chemistry; Seedlings / enzymology; Seedlings / physiology; Self-Fertilization / physiology; Spectrometry, Mass, Electrospray Ionization; Time Factors
TL;DR: High performance liquid chromatography–mass spectrometry-based metabolic profiling analyses showed that leaves, flowers, and young seedlings of F2 plants produced artemisinin, and RT-PCR analysis showed that progeny of self-pollinated plants expressed the amorpha-4, 11-diene synthase (ADS) and cytochrome P450 monooxygenase 71 AV1 (CYP71AV1) genes, which are involved in art Artemisia annua (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Engineering of red cells of Arabidopsis thaliana and comparative genome-wide gene expression analysis of red cells versus wild-type cells

PLANTA, 233(4), 787–805.

By: M. Shi n & D. Xie n

author keywords: Arabidopsis thaliana; Anthocyanin; Biosynthesis; Cyanin; Metabolic engineering; Microarray analysis
MeSH headings : Anthocyanins / chemistry; Anthocyanins / metabolism; Arabidopsis / cytology; Arabidopsis / genetics; Arabidopsis / metabolism; Arabidopsis Proteins; Biosynthetic Pathways; Chromatography, High Pressure Liquid; Gene Expression Profiling; Gene Expression Regulation, Plant; Genes, Plant / genetics; Genetic Engineering / methods; Genome, Plant / genetics; Pancreatitis-Associated Proteins; Principal Component Analysis; Spectrometry, Mass, Electrospray Ionization; Transcription Factors / genetics; Transcription Factors / metabolism
TL;DR: It is suggested that the difference in gene expression profiles between the two cell lines likely results from cell types, the overexpression of PAP1, and the high metabolic flux toward anthocyanins. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Features of anthocyanin biosynthesis in pap1-D and wild-type Arabidopsis thaliana plants grown in different light intensity and culture media conditions

PLANTA, 231(6), 1385–1400.

By: M. Shi n & D. Xie n

author keywords: Anthocyanins; Anthocyanidins; Arabidopsis thaliana; Biosynthesis; Cyanins; Cyanidins; HPLC-ESI-MS; HPLC-TOF-MS; pap1-D-mutant; PAP1; Metabolic profiling; RT-PCR
MeSH headings : Anthocyanins / biosynthesis; Anthocyanins / chemistry; Anthocyanins / metabolism; Arabidopsis / cytology; Arabidopsis / drug effects; Arabidopsis / growth & development; Arabidopsis / radiation effects; Arabidopsis Proteins; Biological Transport / drug effects; Biological Transport / radiation effects; Chromatography, High Pressure Liquid; Culture Media / pharmacology; Gene Expression Regulation, Plant / drug effects; Gene Expression Regulation, Plant / radiation effects; Genes, Dominant / genetics; Genes, Plant / genetics; Glycosylation / drug effects; Glycosylation / radiation effects; Light; Mass Spectrometry; Metabolic Networks and Pathways / drug effects; Metabolic Networks and Pathways / radiation effects; Pancreatitis-Associated Proteins; Pigmentation / drug effects; Pigmentation / genetics; Pigmentation / radiation effects; Plant Leaves / drug effects; Plant Leaves / metabolism; Plant Leaves / radiation effects; RNA, Messenger / genetics; RNA, Messenger / metabolism; Transcription Factors / genetics; Transcription Factors / metabolism
TL;DR: The A. thaliana anthocyanin molecule A11 was most likely the first cyanin derived from the multiple modification steps of cyanidin, and rosette leaves of pap1-D plants produced much higher levels and more diverse molecular profiling of cyanins than those of WT plants. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

In vitro direct organogenesis and micropropagation of Artemisia annua

Journal of Biotechnologie Vegetale, 26, 327–337.

By: K. ALMaarri & D. Xie

Source: NC State University Libraries
Added: November 24, 2021

2010 journal article

Volatile compounds from leaf extracts of Juniperus excelsa growing in Syria via gas chromatography mass spectrometry

ANALYTICAL METHODS, 2(6), 673–677.

By: K. Almaarri n, L. Alamir*, Y. Junaid* & D. Xie n

UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 conference paper

Extraction of Essential Oil and Anatomical Characterization of Oil Cell from Leaves of Litsea Euosma

Proceedings of 2009 International Conference of Natural Products and Traditional Medicine, 737–744.

By: S. Liu, Z. Liu, H. Zhang, S. Cai, G. Chen & D. Xie

Event: 2009 International Conference of Natural Products and Traditional Medicine on October 16, 2009

Source: NC State University Libraries
Added: November 24, 2021

2009 journal article

Shoot regeneration of dwarf dogwood (Cornus canadensis L.) and morphological characterization of the regenerated plants

PLANT CELL TISSUE AND ORGAN CULTURE, 97(1), 27–37.

By: C. Feng n, R. Qu n, L. Zhou n, D. Xie n & Q. Xiang n

author keywords: Cornus canadensis; Organogenesis; Regeneration; Rhizomes; Tissue culture
TL;DR: An efficient regeneration system is reported for a dwarf dogwood species C. canadensis through organogenesis from rejuvenated leaves, which facilitates developing a genetic transformation system to test candidate genes involved in the developmental divergence of inflorescences in Cornus. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

Development of tobacco callus cultures over expressing Arabidopsis PAP1/MYB75 transcription factor and characterization of anthocyanin biosynthesis

Planta, 229(1), 37–51.

By: L. Zhou n, H. Zeng n, M. Shi n & D. Xie n

author keywords: Anthocyanin; Callus; HPLC-mass spectrum; Metabolic profiling; Nicotiana tabacum; PAP1; Tobacco; Transgene
MeSH headings : 2,4-Dichlorophenoxyacetic Acid / pharmacology; Anthocyanins / biosynthesis; Anthocyanins / chemistry; Arabidopsis / drug effects; Arabidopsis / metabolism; Arabidopsis / radiation effects; Arabidopsis Proteins; Chromatography, High Pressure Liquid; Chromatography, Liquid; Indoleacetic Acids / pharmacology; Light; Mass Spectrometry; Nitrates / pharmacology; Pancreatitis-Associated Proteins; Plants, Genetically Modified; Potassium Compounds / pharmacology; Tissue Culture Techniques; Tobacco / cytology; Tobacco / drug effects; Tobacco / genetics; Tobacco / growth & development; Transcription Factors / metabolism
TL;DR: It is demonstrated that dark, nitrogen nutrients, and auxin apparently affect the anthocyanin profiles in PAP1 transgenic callus cultures; and it is suggested that these cell cultures are an appropriate system to study the regulatory function of P AP1 on the anthOCyanin biosynthesis at post-transcriptional level in vivo. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2008 journal article

In vitro studies of tropical woody species

In Vitro Cellular & Developmental Biology - Animal, 44(Supplement), S54.

By: S. Bhatnagar, S. Chandrasekharan, D. Xie & Y. Hong

Source: NC State University Libraries
Added: November 24, 2021

2008 journal article

TAA1-Mediated Auxin Biosynthesis Is Essential for Hormone Crosstalk and Plant Development

Cell, 133(1), 177–191.

By: A. Stepanova n, J. Robertson-Hoyt n, J. Yun n, L. Benavente n, D. Xie n, K. Doležal*, A. Schlereth*, G. Jürgens*, J. Alonso n

Contributors: A. Stepanova n, J. Robertson-Hoyt n, J. Yun n, L. Benavente n, D. Xie n, K. Doležal*, A. Schlereth*, G. Jürgens*, J. Alonso n

MeSH headings : Amino Acid Sequence; Arabidopsis / drug effects; Arabidopsis / embryology; Arabidopsis / genetics; Arabidopsis / metabolism; Biosynthetic Pathways; Ethylenes / pharmacology; Indoleacetic Acids / metabolism; Indoles / metabolism; Molecular Sequence Data; Mutation; Plant Roots / drug effects; Seedlings / metabolism; Sequence Alignment; Tryptophan Transaminase / chemistry; Tryptophan Transaminase / genetics; Tryptophan Transaminase / metabolism
TL;DR: By characterizing the Arabidopsis wei8 mutant, it is found that a small family of genes mediates tissue-specific responses to ethylene, and the IPA route of auxin production is key to generating robust auxin gradients in response to environmental and developmental cues. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Sources: Crossref, NC State University Libraries, Web Of Science, ORCID
Added: August 6, 2018

2006 journal article

Metabolic engineering of proanthocyanidins through co-expression of anthocyanidin reductase and the PAP1 MYB transcription factor

The Plant Journal, 45(6), 895–907.

By: D. Xie*, S. Sharma*, E. Wright*, Z. Wang* & R. Dixon*

author keywords: condensed tannins; metabolic engineering; transcription factor; anthocyanidin reductase
MeSH headings : Anthocyanins / metabolism; Arabidopsis / genetics; Arabidopsis Proteins; Flavonoids / metabolism; Flowers / anatomy & histology; Flowers / metabolism; Medicago / genetics; Oxidoreductases / genetics; Oxidoreductases / metabolism; Pancreatitis-Associated Proteins; Plant Leaves / anatomy & histology; Plant Leaves / metabolism; Plant Proteins / genetics; Plant Proteins / metabolism; Plant Stems / anatomy & histology; Plant Stems / metabolism; Plants, Genetically Modified / anatomy & histology; Plants, Genetically Modified / metabolism; Proanthocyanidins / biosynthesis; Proanthocyanidins / chemistry; Proanthocyanidins / genetics; Proanthocyanidins / metabolism; Protein Engineering; Proto-Oncogene Proteins c-myb / genetics; Proto-Oncogene Proteins c-myb / metabolism; Tobacco / genetics; Transcription Factors / genetics; Transcription Factors / metabolism
TL;DR: The introduction of PAs into plants by combined expression of a MYB family transcription factor and anthocyanidin reductase for conversion of anthochenidin into (epi)-flavan-3-ol reached values that would confer bloat reduction in forage species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 14, 2020

2005 journal article

Proanthocyanidin biosynthesis – still more questions than answers?

Phytochemistry, 66(18), 2127–2144.

By: D. Xie* & R. Dixon*

author keywords: proanthocyanidins; tannins; flavan-3-ols; catechin; epicatechin; anthocyanidin reductase
MeSH headings : Molecular Structure; Plants / metabolism; Proanthocyanidins / biosynthesis; Proanthocyanidins / chemistry; Proanthocyanidins / metabolism
TL;DR: This work reviews the structures of proanthocyanidins reported over the past 12 years in the context of biosynthesis, and summarizes the outstanding questions concerning synthesis from the chemical, biochemical and molecular genetic perspectives. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: May 8, 2020

2004 journal article

Anthocyanidin reductases from Medicago truncatula and Arabidopsis thaliana

Archives of Biochemistry and Biophysics, 422(1), 91–102.

By: D. Xie*, S. Sharma* & R. Dixon*

author keywords: condensed tannins; flavonoids; anthocyanidin; kinetics; model legume
MeSH headings : Amino Acid Sequence; Anthocyanins / metabolism; Arabidopsis / enzymology; Flavonoids / biosynthesis; Flavonoids / chemistry; Flavonoids / pharmacology; Hydrogen-Ion Concentration; Kinetics; Medicago / enzymology; Molecular Sequence Data; NAD / metabolism; NADH, NADPH Oxidoreductases / chemistry; NADH, NADPH Oxidoreductases / genetics; NADH, NADPH Oxidoreductases / metabolism; NADP / metabolism; Recombinant Fusion Proteins / chemistry; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / metabolism; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity; Tannins / biosynthesis; Temperature
TL;DR: The biochemical properties of ANRs from the model legume Medicago truncatula (MtR) and the model crucifer Arabidopsis thaliana (AtANR) are reported, with MtANR showing preference for potential anthocyanidin substrates and AtANR exhibits the reverse preference, with substrate inhibition at high concentrations of cyanidin and pelargonidin. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: May 8, 2020

2004 journal article

Molecular and Biochemical Analysis of Two cDNA Clones Encoding Dihydroflavonol-4-Reductase from Medicago truncatula

Plant Physiology, 134(3), 979–994.

By: D. Xie*, L. Jackson*, J. Cooper*, D. Ferreira* & N. Paiva*

MeSH headings : Alcohol Oxidoreductases / genetics; Alcohol Oxidoreductases / metabolism; Amino Acid Sequence; Anthocyanins / biosynthesis; Base Sequence; Cloning, Molecular; DNA, Complementary / genetics; DNA, Plant / genetics; Escherichia coli / genetics; Flowers / growth & development; Gene Expression; Gene Expression Regulation, Developmental; Gene Expression Regulation, Plant; Isoenzymes / genetics; Isoenzymes / metabolism; Medicago / enzymology; Medicago / genetics; Medicago / growth & development; Molecular Sequence Data; Pigmentation / genetics; Plants, Genetically Modified; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Sequence Homology, Amino Acid; Substrate Specificity; Tannins / biosynthesis; Tobacco / enzymology; Tobacco / genetics; Tobacco / growth & development
TL;DR: Two recombinant DFR proteins very efficiently reduced 5-deoxydihydroflavonol substrates fustin and dihydrorobinetin, substances not previously reported as constituents of M. truncatula. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: March 20, 2021

2004 journal article

Proanthocyanidins - a final frontier in flavonoid research?

New Phytologist, 165(1), 9–28.

By: R. Dixon*, D. Xie* & S. Sharma*

author keywords: condensed tannin; flavonoid biosynthesis; forage quality; metabolic engineering; nutraceutical; proanthocyanidin
MeSH headings : Antineoplastic Agents, Phytogenic; Humans; Molecular Structure; Plant Physiological Phenomena; Plants / genetics; Plants, Genetically Modified; Proanthocyanidins / chemistry; Proanthocyanidins / genetics; Proanthocyanidins / physiology
TL;DR: Molecular genetic approaches are leading to an understanding of the regulatory genes that control proanthocyanidin biosynthesis, and this information, together with increased knowledge of the enzymes specific for the pathway, will facilitate the genetic engineering of plants for introduction of value-added nutraceutical and forage quality traits. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 21, 2021

2003 journal article

Role of Anthocyanidin Reductase, Encoded by BANYULS in Plant Flavonoid Biosynthesis

Science, 299(5605), 396–399.

By: D. Xie*

MeSH headings : Amino Acid Sequence; Anthocyanins / biosynthesis; Anthocyanins / chemistry; Anthocyanins / metabolism; Arabidopsis / enzymology; Arabidopsis / genetics; Arabidopsis Proteins; Catechin / metabolism; Circular Dichroism; Genes, Plant; Magnetic Resonance Spectroscopy; Medicago / enzymology; Medicago / genetics; Molecular Sequence Data; NAD / metabolism; NADH, NADPH Oxidoreductases / genetics; NADH, NADPH Oxidoreductases / metabolism; NADP / metabolism; Oxidation-Reduction; Oxygenases / metabolism; Plants, Genetically Modified; Proanthocyanidins; Recombinant Proteins / metabolism; Seeds / metabolism; Stereoisomerism; Tannins / biosynthesis; Tannins / chemistry; Tobacco / genetics
TL;DR: It is shown that the BANYULS(BAN) genes from Arabidopsis thaliana and Chicago truncatula encode anthocyanidin reductase, which converts anthocianidins to their corresponding 2,3-cis-flavan-3-ols. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 14, 2020

2002 journal article

Agrobacterium-mediated genetic transformation of Acacia mangium

Plant Cell Reports, 20(10), 917–922.

By: D. Xie* & Y. Hong*

author keywords: Acacia mangium; Agrobacterium; genetic transformation; rejuvenation
TL;DR: A protocol was developed for Agrobacterium-mediated genetic transformation of Acacia mangium using rejuvenated shoots as the explant and the incorporation of the NPTII gene into the host genome. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 14, 2020

2001 journal article

Plant Cell, Tissue and Organ Culture, 66(3), 167–173.

By: D. Xie* & Y. Hong*

author keywords: micropropagation; regeneration; thidiazuron
TL;DR: Calli were induced from five types of explants (embryo axes and cotyledons of mature zygotic embryos as well as leaflets, petioles and stems of seedlings) of A. mangium to achieve plant regeneration in callus cultures and plantlets grew up well in the green house. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: Crossref
Added: September 14, 2020

2001 journal article

Regeneration of Acacia mangium through somatic embryogenesis

Plant Cell Reports, 20(1), 34–40.

By: D. Xie* & Y. Hong

TL;DR: Somatic embryogenesis and whole plant regeneration were achieved in callus cultures derived from immature zygotic embryos of Acacia mangium, the first successful report of plant regeneration through somatic embryogenesis for this economically important tropical forest species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 14, 2020

2001 journal article

Selection of hairy root clones of Artemisia annua L. for artemisinin production

Israel Journal of Plant Sciences, 49(2), 129–134.

By: D. Xie*, H. Ye*, G. Li*, Z. Guo*, Z. Zou & Z. Guo

TL;DR: Hairy roots were induced from two kinds of explants and selection of hairy root clones was studied for artemisin in production, showing considerable variations in capacity of growth and branching. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 14, 2020

2000 journal article

Plant Cell, Tissue and Organ Culture, 63(2), 161–166.

By: D. Xie*, L. Wang*, H. Ye* & G. Li*

author keywords: Artemisia annua; artemisinin; hairy root culture; stigmasterol
TL;DR: The results suggest that investigation of secondary metabolites may provide a new insight to study artemisinin production in hairy root cultures. (via Semantic Scholar)
Source: Crossref
Added: September 14, 2020

1999 journal article

ZYGOTIC EMBRYO CULTURE OF TAXUS CHINESIS VAR. MAIREI AND PLANT REGENERATION THROUGH ORGANOGENESIS

Israel Journal of Plant Sciences, 47(4), 287–289.

By: D. Xie* & Z. Guo*

TL;DR: From germinated embryos, adventitious bud induction was achieved by optimizing formular conditions as described in this paper and adventitious roots were induced and complete plantlets were obtained. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 14, 2020

1998 conference paper

Artemisia annua L. Transformation with different Agrobacterium rhizogenesis and large scale culture of hairy roots for Artemisinin (Qinghaosu) production

In P. J. Larkin (Ed.), Agricultural biotechnology : laboratory, field and market : proceedings of the 4th Asia-Pacific Conference on Agricultural Biotechnology, 13-16 July 1998, Darwin, Australia (pp. 134–136). Fyshwick, Canberra: Under the Counter Publishing.

By: D. Xie, H. Ye, G. Li & Z. Guo

Ed(s): P. Larkin

Source: NC State University Libraries
Added: November 24, 2021

1995 journal article

Studies on the karyotype of Artemisia annua

Chinese Bulletin of Botany, 12(Supplement), 71–72.

By: D. Xie, N. Kang & G. Li

Source: NC State University Libraries
Added: November 24, 2021

1995 journal article

The Progress of Artemisia annua research--the application of biotechnology and prospects

Chinese Bulletin of Botany, 12(4), 28–31.

By: D. Xie, H. Ye & G. Li

Source: NC State University Libraries
Added: November 24, 2021

1993 journal article

Studies on the relation between the changes of endogenous IPA and the growth of cell of Arnebia euchroma during the culture

Journal of Jishou University (Natural Science), 14(6), 29–31.

By: D. Xie, G. Li, H. Ye & G. Li

Source: NC State University Libraries
Added: November 24, 2021

1992 journal article

Tissue culture and chromosome analysis of Arnebia euchroma

Chinese Bulletin of Botany, 9(1), 37–41.

By: G. Li, M. Qi, N. Kang, D. Xie, Y. Ye & G. Li

Source: NC State University Libraries
Added: November 24, 2021

conference paper

Biochemical and molecular genetic approaches to proanthocyanidin biosynthesis

Dixon, R. A., Xie, D. Y., Sharma, S. B., Chen, F., & Ferreira, D. Abstracts of papers : 228th ACS National Meeting, American Chemical Society, Philadelphia, PA, August 22-26, 2004, 228, U247. Washington, DC: American Chemical Society.

By: R. Dixon, D. Xie, S. Sharma, F. Chen & D. Ferreira

Event: American Chemical Society National Meeting at Philadelphia, Pennsylvania on August 22-26, 2004

Source: NC State University Libraries
Added: November 24, 2021

Employment

Updated: June 25th, 2014 04:56

2005 - present

North Carolina State University Raleigh, NC, US
Plant and Microbial

Education

Updated: June 25th, 2014 05:00

1994 - 1997

Institute of Botany Chinese Academy of Sciences Beijing, Beijing, CN
PhD Plant Physiology

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