Duncan X. Lascelles
Works (381)
Updated: November 24th, 2024 05:16
2024 journal article
2024 ISFM and AAFP consensus guidelines on the long-term use of NSAIDs in cats
JOURNAL OF FELINE MEDICINE AND SURGERY, 26(4).
author keywords: Carprofen; meloxicam; robenacoxib; analgesia; chronic kidney disease; osteoarthritis; degenerative joint disease; pain management; chronic pain
open access via journals.sagepub.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 24, 2024
2024 journal article
Evaluation of the comparative efficacy of green lipped mussel plus krill oil extracts (EAB-277), <i>Biota orientalis</i> extracts or NSAIDs for the treatment of dogs with osteoarthritis associated pain: a blinded, placebo-controlled study
FRONTIERS IN VETERINARY SCIENCE, 11.
author keywords: OA; marine based fatty acid; omega 3; NSAID; gait analysis; PVF
Sources: Web Of Science, NC State University Libraries
Added: November 4, 2024
2024 article
Gut Microbiome and Osteoarthritis: Insights From the Naturally Occurring Canine Model of Osteoarthritis
Stevens, C., Norris, S., Arbeeva, L., Carter, S., Enomoto, M., Nelson, A. E., & Lascelles, B. D. X. (2024, August 9). ARTHRITIS & RHEUMATOLOGY, Vol. 8.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 19, 2024
2024 article
Pharmacokinetics of subcutaneous ketamine administration via the Omnipod® system in dogs
Colon, C., Early, P., Munana, K., Olby, N., Mariani, C., Mancini, S., … Messenger, K. (2024, March 27). JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, Vol. 3.
author keywords: analgesia; canine; ketamine; novel; veterinary
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 8, 2024
2024 journal article
Prevalence of radiographic appendicular osteoarthritis and associated clinical signs in young dogs
SCIENTIFIC REPORTS, 14(1).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 1, 2024
2024 journal article
Response to treatment with grapiprant as part of a standard multimodal regimen in young dogs with appendicular joint osteoarthritis associated pain
FRONTIERS IN VETERINARY SCIENCE, 11.
author keywords: osteoarthritis; pain; dog; grapiprant; force plate; fish oil; exercise
Sources: Web Of Science, NC State University Libraries
Added: November 18, 2024
2024 journal article
Use of Bedinvetmab (Librela®) for Canine Osteoarthritis in France, Germany, Italy, Spain, and the UK: Quantitative Analysis of Veterinarian Satisfaction and Real-World Treatment Patterns
ANIMALS, 14(15).
author keywords: bedinvetmab; Librela; canine osteoarthritis; real-world; pain; canine degenerative joint disease
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 19, 2024
2023 journal article
Activity patterns are associated with fractional lifespan, memory, and gait speed in aged dogs
SCIENTIFIC REPORTS, 13(1).
MeSH headings : Humans; Dogs; Animals; Alzheimer Disease; Longevity; Walking Speed; Gait; Cognition; Cognitive Dysfunction; Aging / psychology; Pain
TL;DR:
It is found that activity patterns in dogs are associated with fractional lifespan and working memory, and dogs with higher on/off leash gait speed are more active in the afternoon of weekdays.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 19, 2023
2023 journal article
Acute radiotherapy-associated oral pain may promote tumor growth at distant sites
FRONTIERS IN ONCOLOGY, 13.
author keywords: pain; radiotherapy; sensory nerves; cancer; mouse; TRPV1
TL;DR:
This research points towards radiation-induced activation of capsaicin-responsive (TRPV1) neurons as the cause for accelerated growth of tumors at distant (unirradiated) sites.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 12, 2023
2023 article
An Exploration of Machine Learning Methods for Gait Analysis of Potential Guide Dogs
TENTH INTERNATIONAL CONFERENCE ON ANIMAL-COMPUTER INTERACTION, ACI 2023.
author keywords: Guide Dog; Canine Behavior Analysis; Canine Gait Analysis; IMU; Machine Learning
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 22, 2024
2023 review
COAST Development Group's international consensus guidelines for the treatment of canine osteoarthritis
[Review of ]. FRONTIERS IN VETERINARY SCIENCE, 10.
author keywords: dog; pain; osteoarthritis; staging; management; treatment guidelines; COASTeR; COAST
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 5, 2023
2023 journal article
Development and validation of a sleep questionnaire, SNoRE 3.0, to evaluate sleep in companion dogs
SCIENTIFIC REPORTS, 13(1).
TL;DR:
A valid and reliable questionnaire tool is described, that can be used as a cost-effective way to monitor dog sleep in clinical settings.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
8. Decent Work and Economic Growth
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 23, 2023
2023 journal article
Minimal clinically-important differences for the 'Liverpool Osteoarthritis in Dogs' (LOAD) and the 'Canine Orthopedic Index' (COI) client-reported outcomes measures
PLOS ONE, 18(2).
TL;DR:
Estimates for MCIDs for these two CROMs are provided which will facilitate sample size estimates in future clinical studies that use theseCROMs as outcomes measures and show that the value of the MCIDs depended on the method that was applied.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 3, 2023
2023 article
Multi-Functional Small Molecule Alleviates Fracture Pain and Promotes Bone Healing
Shih, Y.-R. V., Kingsley, D., Newman, H., Hoque, J., Gupta, A., Lascelles, B. D. X., & Varghese, S. (2023, November 8). ADVANCED SCIENCE, Vol. 11.
author keywords: adenosine; adenosine receptors; biomaterials; drug delivery; fracture healing; fracture pain; phenylboronic acids
TL;DR:
The results demonstrate that local delivery of adenosine inhibited the nociceptive activity of peripheral neurons through activation of adenosine A1 receptor (ADORA1) and mitigated pain as demonstrated by weight bearing and open field movement tests.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 26, 2023
2023 journal article
Nine-axis inertial measurement unit output discriminates activities of varying intensity in the dog
AMERICAN JOURNAL OF VETERINARY RESEARCH, 84(3), 8–8.
MeSH headings : Dogs; Animals; Biomechanical Phenomena; Walking; Acceleration
TL;DR:
The long-range goal is to validate an open-source algorithm for the IMU so activity in a pet's natural environment can be used as an outcome measure in future studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 4, 2023
2023 journal article
Pain sensitivity differs between dog breeds but not in the way veterinarians believe
FRONTIERS IN PAIN RESEARCH, 4.
author keywords: healthcare provider beliefs; attitudes; stereotypes; perceptions of patient pain; canine behavior; quantitative sensory testing; animal welfare; affective states
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 21, 2023
2023 journal article
Study of the effectiveness of glucosamine and chondroitin sulfate, marine based fatty acid compounds (PCSO-524 and EAB-277), and carprofen for the treatment of dogs with hip osteoarthritis: A prospective, block-randomized, double-blinded, placebo-controlled clinical trial
FRONTIERS IN VETERINARY SCIENCE, 10.
author keywords: OA; marine-based fatty acid; non-steroidal anti-inflammatory drug (NSAID); gait analysis; PVF
TL;DR:
PCSO-524 and EAB-277, but not glucosamine/chondroitin, resulted in significant improvements in PVF from baseline after 4 weeks, 6 weeks, and to a similar degree to that seen with carprofen.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 6, 2023
2023 article
Study of the effectiveness of glucosamine and chondroitin sulfate, marine based fatty acid compounds (PCSO-524 and EAB-277), and carprofen for the treatment of dogs with hip osteoarthritis: a prospective, block-randomized, double-blinded, placebo-controlled clinical trial (vol 10, 1033188, 2023)
Kampa, N., Kaenkangploo, D., Jitpean, S., Srithunyarat, T., Seesupa, S., Hoisang, S., … Lascelles, B. D. X. (2023, August 2). FRONTIERS IN VETERINARY SCIENCE, Vol. 10.
author keywords: OA; marine-based fatty acid; non-steroidal anti-inflammatory drug (NSAID); gait analysis; PVF
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 5, 2023
2023 journal article
Veterinary education and experience shape beliefs about dog breeds Part 1: Pain sensitivity
SCIENTIFIC REPORTS, 13(1).
TL;DR:
It is suggested that veterinary education and clinical experiences influence pain sensitivity ratings across dog breeds, and veterinary students rated pain sensitivity across breeds of dog more similarly to veterinary faculty and staff.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 2, 2024
2022 journal article
2022 AAHA Pain Management Guidelines for Dogs and Cats
JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 58(2), 55–76.
MeSH headings : Animals; Cat Diseases / diagnosis; Cat Diseases / drug therapy; Cats; Dog Diseases / drug therapy; Dogs; Pain / drug therapy; Pain / veterinary; Pain Management / veterinary; Pain Measurement / veterinary
TL;DR:
These updated guidelines present a practical and logical approach to the assessment and management of acute and chronic pain in canine and feline patients, and include a tiered decision tree that prioritizes the use of the most efficacious therapeutic modalities for the treatment of chronic pain.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 18, 2022
2022 article
2022 WSAVA guidelines for the recognition, assessment and treatment of pain
Monteiro, B. P., Lascelles, B. D. X., Murrell, J., Robertson, S., Steagall, P. V. M., & Wright, B. (2022, October 27). JOURNAL OF SMALL ANIMAL PRACTICE, Vol. 10.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 7, 2022
2022 journal article
A Pilot, Open-Label Study to Evaluate the Efficacy of Intra-Articular Administration of a Caninized TNF Receptor Fc Fusion Protein as a Treatment for Osteoarthritis-Associated Joint Pain
FRONTIERS IN VETERINARY SCIENCE, 9.
author keywords: osteoarthritis; joint pain; TNF-alpha; force plate; limb use asymmetry test
TL;DR:
The IA injection of caTNFR-Fc fusion protein provided no benefit in terms of objective limb use and activity data in dogs with OA in this pilot study, and data indicate TNF-α may not be a good therapeutic target in canine OA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 27, 2022
2022 journal article
Determination of the center of mass in a heterogeneous population of dogs
PLOS ONE, 17(4).
MeSH headings : Acceleration; Animals; Back; Dogs
TL;DR:
Dog length was the primary variable required to maximize the relationship between three-dimensional CoM and identifiable variables measured, and a CoM based normalization procedure should be considered to normalize mass or motion based outcome measure output in a heterogeneous population of dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 29, 2022
2022 article
Identification of canine osteoarthritis using an owner-reported questionnaire and treatment monitoring using functional mobility tests
Wright, A., Amodie, D. M., Cernicchiaro, N., Lascelles, B. D. X., Pavlock, A. M., Roberts, C., & Bartram, D. J. (2022, April 6). JOURNAL OF SMALL ANIMAL PRACTICE, Vol. 4.
MeSH headings : Animals; Chronic Pain / veterinary; Dog Diseases / diagnosis; Dog Diseases / drug therapy; Dogs; Osteoarthritis / diagnosis; Osteoarthritis / drug therapy; Osteoarthritis / veterinary; Pain Measurement / veterinary; Surveys and Questionnaires
TL;DR:
More osteoarthritis cases were identified in study dogs than previous prevalence estimates, indicating the screening checklist's potential to help identify for further evaluation cases that could otherwise remain undiagnosed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 25, 2022
2022 journal article
Initial exploration of the discriminatory ability of the PetPace collar to detect differences in activity and physiological variables between healthy and osteoarthritic dogs
FRONTIERS IN PAIN RESEARCH, 3.
Contributors: J. Robertson n
author keywords: canine; physical activity monitor; osteoarthritis; mobility; pain; accelerometry
TL;DR:
The results of this study suggest that the PetPace collar can detect differences between healthy dogs and those with OA-pain, and that Oa-pain negatively impacts overall activity levels in dogs, and especially higher intensity activity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 7, 2022
2022 article
Intensity of perioperative analgesia but not pre-treatment pain is predictive of survival in dogs undergoing amputation plus chemotherapy for extremity osteosarcoma
Nolan, M. W., Uzan, O. C., Green, N. A., Lana, S. E., & Lascelles, B. D. X. (2022, March 21). VETERINARY AND COMPARATIVE ONCOLOGY, Vol. 3.
author keywords: analgesia; cancer pain; cancer treatment pain; local anaesthesia; malignant osteolysis
MeSH headings : Amputation, Surgical / veterinary; Analgesia / veterinary; Animals; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Bone Neoplasms / drug therapy; Bone Neoplasms / surgery; Bone Neoplasms / veterinary; Dog Diseases / drug therapy; Dog Diseases / surgery; Dogs; Extremities / surgery; Osteosarcoma / drug therapy; Osteosarcoma / surgery; Osteosarcoma / veterinary; Pain / drug therapy; Pain / veterinary; Retrospective Studies; Treatment Outcome
TL;DR:
In dogs treated with limb amputation and adjunctive chemotherapy for osteosarcoma, oncologic outcomes are impacted by either baseline cancer pain severity, or the approaches used for perioperative pain management.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 4, 2022
2022 journal article
Investigating the Role of Artemin and Its Cognate Receptor, GFR alpha 3, in Osteoarthritis Pain
FRONTIERS IN NEUROSCIENCE, 16.
author keywords: pain; osteoarthritis (OA); artemin; GFR alpha 3; TRPV1; monoiodoacetate (MIA)
TL;DR:
The results provide a molecular basis of arthritis pain linked with artemin/GFRα3 signaling and indicate that further work is warranted to investigate the neuronal plasticity and the pathways that drive pain in OA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 28, 2022
2022 article
Long-term follow up of 44 cats undergoing total hip replacement: Cases from a feline hip registry (2010-2020)
Tilve, V. R., Allaith, S., Girling, S., Moores, A. P., Mulholland, L., Morrison, S., … Comerford, E. (2022, June 1). VETERINARY SURGERY, Vol. 6.
MeSH headings : Animals; Arthroplasty, Replacement, Hip / adverse effects; Arthroplasty, Replacement, Hip / veterinary; Cats / surgery; Follow-Up Studies; Hip Prosthesis / veterinary; Humans; Male; Registries; Retrospective Studies; Treatment Outcome
TL;DR:
A validated client metrology questionnaire showed clinical improvement in cats following THR, and total hip replacement appears to be a successful surgical treatment for feline hip disease with very good owner satisfaction and acceptable complication rates.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 13, 2022
2022 journal article
Pilot comparison of outcome measures across chemical and surgical experimental models of chronic osteoarthritis in the rat (Rattus norvegicus)
PLOS ONE, 17(11).
Ed(s): A. Wijnen
MeSH headings : Rats; Animals; Rats, Sprague-Dawley; Lameness, Animal; Disease Models, Animal; Osteoarthritis / complications; Pain / complications; Models, Anatomic; Outcome Assessment, Health Care
TL;DR:
The pilot data suggest both the ACL+DMM and MIA models are equal in terms of clinically relevant pain behaviors, but the MIA model is associated with more severe histological changes over time potentially making it more suitable for screening disease modifying agents.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 22, 2022
2022 article
Spatial and Temporal Analytic Pipeline for Evaluation of Potential Guide Dogs Using Location and Behavior Data
NINTH INTERNATIONAL CONFERENCE ON ANIMAL-COMPUTER INTERACTION, ACI 2022.
author keywords: Guide Dog; Canine Behavior Analysis; Feature Extraction; IMU; Machine Learning; Clustering
TL;DR:
A preliminary data analysis workflow is demonstrated that is able to provide detailed information about candidate guide dogs’ day to day physical exercise levels and gait activities using objective environmental and behavioral data collected from a wearable collar-based Internet of Things device.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 30, 2023
2022 journal article
Static posturography as a novel measure of the effects of aging on postural control in dogs
PLOS ONE, 17(7).
Ed(s): R. Evans
MeSH headings : Acceleration; Aging; Animals; Arthralgia; Dogs; Postural Balance; Reproducibility of Results
TL;DR:
It is found that pressure sensitive walkway systems are a reliable tool to evaluate postural sway in dogs; and that postural swayed is affected by morphometric parameters and increases with age and joint pain.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 12, 2022
2021 journal article
Assessment of Sensory Thresholds in Dogs using Mechanical and Hot Thermal Quantitative Sensory Testing
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 10(176).
MeSH headings : Animals; Dogs; Hot Temperature; Humans; Osteoarthritis; Pain; Pain Measurement / methods; Pain Threshold / physiology; Reproducibility of Results; Sensory Thresholds / physiology
TL;DR:
The QST operator and handler should be familiar and comfortable with handling dogs and interpreting dogs' behavioral responses to potentially painful stimuli to determine the endpoint of testing, reduce stress, and maintain safety during the testing process.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 15, 2021
2021 journal article
Behavioral phenotyping of cancer pain in domesticated cats with naturally occurring squamous cell carcinoma of the tongue: initial validation studies provide evidence for regional and widespread algoplasticity
PEERJ, 9.
author keywords: Comparative oncology; Comparative pain research; Animal models; Translational research; Feline
TL;DR:
Based on preliminary assessments, the assays described herein had reasonable inter-rater reliability, and they were able to both discriminate between cats with and without oral cancer, and respond in a predictable manner to analgesic therapy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 30, 2021
2021 journal article
Biological resurfacing in a canine model of hip osteoarthritis
SCIENCE ADVANCES, 7(38).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 16, 2021
2021 article
Clinical safety of robenacoxib in cats with chronic musculoskeletal disease
King, J. N., Seewald, W., Forster, S., Friton, G., Adrian, D. E., & Lascelles, B. D. X. (2021, July 1). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 7.
author keywords: adverse event; coxib; harm; NSAID
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / adverse effects; Cat Diseases / drug therapy; Cats; Diphenylamine / adverse effects; Diphenylamine / analogs & derivatives; Musculoskeletal Diseases / drug therapy; Musculoskeletal Diseases / veterinary; Phenylacetates; Prospective Studies
TL;DR:
Robenacoxib was not associated with increased risk of AEs compared to placebo when administered for 4 to 12 weeks to cats with CMSD and generalizability of the results to general practice is limited by the fact that cases with severe and uncontrolled concomitant diseases were not included.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: July 12, 2021
2021 article
Defining the rate of, and factors influencing, radiographic progression of osteoarthritis of the canine hip joint
Enomoto, M., Baines, E. A., Roe, S. C., Marcellin-Little, D. J., & Lascelles, B. D. X. (2021, June 12). VETERINARY RECORD, Vol. 6.
MeSH headings : Animals; Arthroplasty, Replacement, Hip / veterinary; Dog Diseases / diagnostic imaging; Dog Diseases / surgery; Dogs; Female; Hip Joint / diagnostic imaging; Hip Joint / surgery; Osteoarthritis, Hip / diagnostic imaging; Osteoarthritis, Hip / surgery; Osteoarthritis, Hip / veterinary; Radiography
TL;DR:
The rate of progression of radiographically assessed coxofemoral OA varies greatly, but is faster in younger, spayed female dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 16, 2021
2021 article
Evaluation of a nutritional supplement for the alleviation of pain associated with feline degenerative joint disease: a prospective, randomized, stratified, double-blind, placebo-controlled clinical trial
Cunningham, R., Gruen, M. E., Thomson, A., & Lascelles, B. D. X. (2021, November 1). JOURNAL OF FELINE MEDICINE AND SURGERY, Vol. 11.
author keywords: Glucosamine hydrochloride; chondroitin sulfate; nutritional supplement; mobility; accelerometer; activity
MeSH headings : Animals; Cat Diseases / drug therapy; Cats; Chondroitin Sulfates / therapeutic use; Double-Blind Method; Glucosamine / therapeutic use; Joint Diseases / veterinary; Musculoskeletal Pain / drug therapy; Musculoskeletal Pain / veterinary; Prospective Studies; Quality of Life; Treatment Outcome
TL;DR:
This study showed a strong placebo effect and the glucosamine/chondroitin sulfate supplement did not show pain-relieving effects when compared with placebo, and no differences in activity were seen between the groups.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 2, 2021
2021 article
Frunevetmab, a felinized anti-nerve growth factor monoclonal antibody, for the treatment of pain from osteoarthritis in cats
Gruen, M. E., Myers, J. A. E., Tena, J.-K. S., Becskei, C., Cleaver, D. M., & Lascelles, B. D. X. (2021, November 1). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 11.
author keywords: arthritis; client specific outcome measures; CSOM; degenerative joint disease; feline; feline musculoskeletal pain index; FMPI
MeSH headings : Animals; Antibodies, Monoclonal / therapeutic use; Cat Diseases / drug therapy; Cats; Double-Blind Method; Osteoarthritis / drug therapy; Osteoarthritis / veterinary; Pain / veterinary; Surveys and Questionnaires; Treatment Outcome
TL;DR:
Frunevetmab has the potential to address a critical gap in the treatment of pain because of osteoarthritis in cats and has been evaluated in a randomized, placebo‐controlled, parallel‐group, double‐blind superiority study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 2, 2021
2021 review
Injectable Capsaicin for the Management of Pain Due to Osteoarthritis
[Review of ]. MOLECULES, 26(4).
author keywords: intra-articular; cooling; knee; defunctionalization; nociceptive fiber; TRPV1; primary afferent; nociceptor; disruption
MeSH headings : Animals; Capsaicin / therapeutic use; Humans; Neuralgia / drug therapy; Neuralgia / metabolism; Neuralgia / pathology; Nociceptors / metabolism; Nociceptors / pathology; Osteoarthritis / drug therapy; Osteoarthritis / metabolism; Osteoarthritis / pathology; TRPV Cation Channels / antagonists & inhibitors; TRPV Cation Channels / metabolism
TL;DR:
This review focuses on the rationale for using capsaicin by injection for painful conditions such as osteoarthritis and provides an update on studies completed to date.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 8, 2021
2021 journal article
Irradiation of the Normal Murine Tongue Causes Upregulation and Activation of Transient Receptor Potential (TRP) Ion Channels
RADIATION RESEARCH, 196(4), 331–344.
MeSH headings : Animals; Calcium; Female; Mice; Neurons; Transient Receptor Potential Channels; Trigeminal Ganglion; Up-Regulation
TL;DR:
The results intimate that various TRP channels, and TRPV1 in particular, should be explored as analgesic targets for patients experiencing pain after oral irradiation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 18, 2021
2021 journal article
Novel approach to modeling high-frequency activity data to assess therapeutic effects of analgesics in chronic pain conditions
SCIENTIFIC REPORTS, 11(1).
MeSH headings : Analgesics / therapeutic use; Animals; Cat Diseases / drug therapy; Cats; Chronic Pain / drug therapy; Chronic Pain / veterinary; Cross-Over Studies; Double-Blind Method; Markov Chains; Models, Theoretical; Placebos; Poisson Distribution
TL;DR:
A zero inflated Poisson hidden semi-Markov model is used to characterize activity patterns and derive estimators of the treatment effect in terms of changes in activity levels or frequency of activity type using data from a naturally occurring feline OA-associated pain model.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 10, 2021
2021 article
Refinement of the Feline Musculoskeletal Pain Index (FMPI) and development of the short-form FMPI
Enomoto, M., Lascelles, B. D. X., Robertson, J. B., & Gruen, M. E. (2021, May 18). JOURNAL OF FELINE MEDICINE AND SURGERY, Vol. 5.
author keywords: Osteoarthritis; pain; musculoskeletal disease; degenerative joint disease; behavioral change; outcome measure
MeSH headings : Analgesics; Animals; Cat Diseases / diagnosis; Cat Diseases / drug therapy; Cats; Musculoskeletal Pain / veterinary; Reproducibility of Results; Surveys and Questionnaires
TL;DR:
The proposed FMPI-sf may be able to better distinguish between placebo and analgesic effects in cats with DJD and its reliability was reassessed using the data sets described above.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: May 19, 2021
2021 journal article
Robenacoxib shows efficacy for the treatment of chronic degenerative joint disease-associated pain in cats: a randomized and blinded pilot clinical trial
Scientific Reports Volume, 11(1), 7721.
MeSH headings : Animals; Cat Diseases / drug therapy; Cats; Diphenylamine / analogs & derivatives; Diphenylamine / therapeutic use; Female; Joint Diseases / complications; Joint Diseases / veterinary; Male; Osteoarthritis / complications; Osteoarthritis / veterinary; Pain / complications; Pain / veterinary; Pain Management / veterinary; Phenylacetates / therapeutic use; Pilot Projects; Placebos
TL;DR:
Results identified suitable endpoints for confirmatory studies, while also indicating efficacy of robenacoxib in cats with DJD-pain, and decreased owner-assessed disability.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 18, 2021
2021 journal article
Serum artemin is not correlated with sensitivity within dogs with naturally occurring osteoarthritis pain
SCIENTIFIC REPORTS, 11(1).
MeSH headings : Animals; Arthralgia / diagnosis; Arthralgia / etiology; Dogs; Female; Male; Nerve Tissue Proteins / blood; Osteoarthritis / blood; Osteoarthritis / complications; Pain Threshold; Severity of Illness Index; Symptom Assessment
TL;DR:
Serum ARTN was not associated with the degree of sensitization within dogs with OAP, and across dogs with varying OAP severity, there did not find any association between ARTN, and clinical measures of joint pain and disability, although a relationship between Artemin and joint pain was not ruled out.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 19, 2021
2020 journal article
A functional linear modeling approach to sleep-wake cycles in dogs
SCIENTIFIC REPORTS, 10(1).
MeSH headings : Algorithms; Animals; Behavior, Animal; Dogs; Models, Biological; Sleep / physiology; Wakefulness / physiology
TL;DR:
It is demonstrated that FLM can be used to describe normal sleep–wake cycles of healthy adult dogs and the effects of physiologic traits on these patterns of activity, and makes it possible to characterize deviations from normal patterns, including those associated with chronic pain and cognitive dysfunction syndrome.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 25, 2021
2020 journal article
Atenolol in cats with subclinical hypertrophic cardiomyopathy: a double-blind, placebo-controlled, randomized clinical trial of effect on quality of life, activity, and cardiac biomarkers
JOURNAL OF VETERINARY CARDIOLOGY, 30, 77–91.
author keywords: Feline; Beta-btocker; Accelerometry
MeSH headings : Administration, Oral; Animals; Anti-Arrhythmia Agents / administration & dosage; Anti-Arrhythmia Agents / therapeutic use; Atenolol / administration & dosage; Atenolol / therapeutic use; Biomarkers / blood; Cardiomyopathy, Hypertrophic / drug therapy; Cardiomyopathy, Hypertrophic / veterinary; Cat Diseases / blood; Cat Diseases / drug therapy; Cats; Double-Blind Method; Female; Male; Quality of Life; Treatment Outcome
TL;DR:
This study failed to identify an effect of subclinical HCM on owner-assessed QOL or activity or a treatment effect of atenolol on these variables at the dosage evaluated, and these findings do not support a treatment benefit of atanolol for the goal of symptom reduction in cats with sub clinical HCM.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 21, 2020
2020 review
Early Neonatal Pain-A Review of Clinical and Experimental Implications on Painful Conditions Later in Life
[Review of ]. FRONTIERS IN PEDIATRICS, 8.
author keywords: neonatal pain; early life; consequences; neurobiology; mechanisms; animal models; chronic pain
TL;DR:
A narrative review of the literature pertaining to the idea that early life pain has significant long-term effects on neurosensory, cognition, behavior, pain processing, and health outcomes that persist into childhood and even adulthood is provided.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: March 23, 2020
2020 journal article
Early radiation‐induced oral pain signaling responses are reduced with pentoxifylline treatment
Veterinary Radiology & Ultrasound, 62(2), 255–263.
author keywords: glossitis; mucositis; TNF‐ α TRPV1; TRPV4
MeSH headings : Animals; Capsaicin / pharmacology; Histamine / pharmacology; Mice; Pain / prevention & control; Pain / veterinary; Pentoxifylline / therapeutic use; Pilot Projects; Prospective Studies; Radiation-Protective Agents / therapeutic use; Radiotherapy / adverse effects; Sensory System Agents / pharmacology; Signal Transduction / drug effects; Stomatitis / complications; Stomatitis / drug therapy; Stomatitis / etiology; Tumor Necrosis Factor-alpha / analysis; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
Although PTX treatment did not reduce glossitis severity or mitigate weight loss in mice with RIM/RAP, it did inhibit the upregulation of TNF-α's receptor that normally accompanies RIM, and it also reduced neuronal responsiveness to each of the aforementioned chemical stimuli.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: January 11, 2021
2020 journal article
Glaucoma-associated pain results in mechanical sensitivity changes in dogs: A pilot study
VETERINARY OPHTHALMOLOGY, 24, 116–124.
author keywords: canine; central sensitization; chronic glaucoma; corneal esthesiometry; ocular pain; quantitative sensory testing
MeSH headings : Animals; Chronic Disease / veterinary; Dog Diseases / physiopathology; Dog Diseases / surgery; Dogs; Eye Enucleation / veterinary; Female; Glaucoma / complications; Glaucoma / surgery; Glaucoma / veterinary; Male; Pain / etiology; Pain / veterinary; Pain Measurement / veterinary; Pain Threshold; Physical Stimulation; Pilot Projects; Prospective Studies; Sensory Thresholds
TL;DR:
Sensitivity to mechanical stimuli decreased both locally and at remote sites in dogs following enucleation for painful chronic glaucoma and Cranial conformation is associated with differences in sensitivity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 27, 2020
2020 review
Ice therapy: cool, current and complicated
[Review of ]. JOURNAL OF SMALL ANIMAL PRACTICE, 61(5), 267–271.
MeSH headings : Animals; Cryotherapy / veterinary; Ice; Pain / veterinary; Pain Management / veterinary
TL;DR:
The physiological effects of cold therapy on tissues, receptors and ion channels are discussed; as well as indications, recommendations for, and limitations of use.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 27, 2020
2020 journal article
Impact of radiation dose and pre-treatment pain levels on survival in dogs undergoing radiotherapy with or without chemotherapy for presumed extremity osteosarcoma
VETERINARY AND COMPARATIVE ONCOLOGY, 18(4), 538–547.
author keywords: analgesia; appendicular bone tumour; malignant osteolysis; palliative; primary bone tumour; radiosurgery
MeSH headings : Animals; Antineoplastic Agents / therapeutic use; Bone Neoplasms / drug therapy; Bone Neoplasms / mortality; Bone Neoplasms / radiotherapy; Bone Neoplasms / veterinary; Dog Diseases / drug therapy; Dog Diseases / mortality; Dog Diseases / radiotherapy; Dogs; Female; Fractures, Bone / complications; Fractures, Bone / veterinary; Lung Neoplasms / radiotherapy; Lung Neoplasms / secondary; Male; North Carolina / epidemiology; Osteosarcoma / drug therapy; Osteosarcoma / mortality; Osteosarcoma / radiotherapy; Osteosarcoma / veterinary; Pain / veterinary; Radiation Dosage; Radiotherapy / methods; Radiotherapy / veterinary; Retrospective Studies; Survival
TL;DR:
In a univariate analysis, dogs with pulmonary metastases and high pain at the time of irradiation had short overall survival times; use of high radiation doses and chemotherapy were associated with improved survival.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 10, 2020
2020 journal article
Local Administration of Carboplatin in Poloxamer 407 After an Ulnar Osteosarcoma Removal in a Dog
JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 56(6), 325–330.
MeSH headings : Amputation, Surgical / veterinary; Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / therapeutic use; Bone Neoplasms / therapy; Bone Neoplasms / veterinary; Carboplatin / administration & dosage; Carboplatin / therapeutic use; Dog Diseases / drug therapy; Dogs; Forelimb / pathology; Forelimb / surgery; Male; Neoplasm Recurrence, Local / surgery; Neoplasm Recurrence, Local / veterinary; Osteosarcoma / therapy; Osteosarcoma / veterinary; Poloxamer / chemistry
TL;DR:
This is the first report in the veterinary literature of using poloxamer 407 as a carrier for local delivery of chemotherapeutic drugs in a clinical patient.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 22, 2021
2020 journal article
Protease activated receptor 2 and matriptase expression in the joints of cats with and without osteoarthritis
JOURNAL OF FELINE MEDICINE AND SURGERY, 23(8), 794–803.
author keywords: PAR2; matriptase; osteoarthritis; cartilage; synovium
MeSH headings : Animals; Cartilage, Articular; Cat Diseases; Cats; Chondrocytes; Osteoarthritis / veterinary; Receptor, PAR-2; Serine Endopeptidases
TL;DR:
D detection of PAR2 and matriptase proteins and gene expression in feline articular tissues is a novel and important finding, and supports the hypothesis that serine proteases are involved in the pathogenesis of feline OA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 19, 2021
2020 article
The effectiveness of marine based fatty acid compound (PCSO-524) and firocoxib in the treatment of canine osteoarthritis (vol 15, 349, 2019)
Vijarnsorn, M., Kwananocha, I., Kashemsant, N., Jarudecha, T., Lekcharoensuk, C., Beale, B., … Lascelles, B. D. X. (2020, December 16). BMC VETERINARY RESEARCH, Vol. 16.
TL;DR:
An amendment to this paper has been published and can be accessed via the original article.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 4, 2021
2019 journal article
Clinical measurements performed during alfaxalone total intravenous anaesthesia for radiography and neurophysiological investigations in dogs
VETERINARY ANAESTHESIA AND ANALGESIA, 46(4), 483–487.
author keywords: alfaxalone; dog; total intravenous anaesthesia
MeSH headings : Anesthesia, Intravenous / veterinary; Anesthetics / administration & dosage; Anesthetics / adverse effects; Anesthetics / pharmacology; Animals; Apnea / chemically induced; Apnea / veterinary; Blood Glucose; Blood Pressure / drug effects; Carbon Dioxide / blood; Case-Control Studies; Dog Diseases / diagnostic imaging; Dogs; Female; Heart Rate / drug effects; Male; Osteoarthritis / diagnostic imaging; Osteoarthritis / veterinary; Oxygen / blood; Pregnanediones / administration & dosage; Pregnanediones / adverse effects; Pregnanediones / pharmacology; Radiography / veterinary; Respiration / drug effects
TL;DR:
Alfaxalone infusion provided effective anaesthesia in this population of middle-aged or older dogs and in a minority of cases, respiratory and haemodynamic support of the patient was required.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: July 15, 2019
2019 journal article
Evaluation and comparison of pain questionnaires for clinical screening of osteoarthritis in cats
VETERINARY RECORD, 185(24).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: February 17, 2020
2019 review
Intraperitoneal and incisional analgesia in small animals: simple, cost-effective techniques
[Review of ]. JOURNAL OF SMALL ANIMAL PRACTICE, 61(1), 19–23.
MeSH headings : Analgesia / veterinary; Animals; Cost-Benefit Analysis; Pain / veterinary; Pain Management / veterinary
TL;DR:
The World Small Animal Veterinary Association Global Pain Council (WSAVA-GPC) has recently published its first "capsule review" by Monteiro et al, where the use of intraperitoneal and incisional analgesia in small animal practice is discussed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: December 2, 2019
2019 journal article
Itch-associated Neuropeptides and Their Receptor Expression in Dog Dorsal Root Ganglia and Spinal Cord
ACTA DERMATO-VENEREOLOGICA, 99(12), 1131–1135.
Contributors: J. Wheeler*, B. Lascelles n, T. Olivry n & S. Mishra*
author keywords: dog; canine atopic dermatitis; somatostatin; NPPB; NMB; GRP
MeSH headings : Animals; Calcium Signaling; Cells, Cultured; Dogs; Female; Ganglia, Spinal / metabolism; Ganglia, Spinal / physiopathology; Gene Expression Regulation; Male; Neuropeptides / genetics; Neuropeptides / metabolism; Pruritus / genetics; Pruritus / metabolism; Pruritus / physiopathology; Receptors, Neuropeptide / genetics; Receptors, Neuropeptide / metabolism; Spinal Cord / metabolism; Spinal Cord / physiopathology
TL;DR:
The results provide the first evidence that dogs use similar pruritogenic pathways to those characterized in mice and thus identify multiple targets for the future treatment of itch in dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: December 2, 2019
2019 review
Long-term use of non-steroidal anti-inflammatory drugs in cats with chronic kidney disease: from controversy to optimism
[Review of ]. JOURNAL OF SMALL ANIMAL PRACTICE, 60(8), 459–462.
MeSH headings : Analgesics / therapeutic use; Animals; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Cat Diseases; Cats; Pain / veterinary; Renal Insufficiency, Chronic / veterinary
TL;DR:
The scientific evidence available on the long-term use of non-steroidal anti-inflammatory drugs in cats with concomitant chronic pain and chronic kidney disease is discussed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 12, 2019
2019 review
Measurement of chronic pain in companion animals: Discussions from the Pain in Animals Workshop (PAW) 2017
[Review of ]. VETERINARY JOURNAL, 250, 71–78.
author keywords: Cat; Chronic; Dog; Measurement; Pain
MeSH headings : Animals; Cat Diseases / pathology; Cats; Chronic Pain / pathology; Chronic Pain / veterinary; Dog Diseases / pathology; Dogs; Pain Measurement / veterinary
TL;DR:
There is a considerable interest in improving the assessment of chronic pain, as evidenced by the multiple disciplines across industry, academia, and clinical practice from the veterinary and human medical fields that participated in the Pain in Animals Workshop held at the National Institutes of Health in 2017.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: September 16, 2019
2019 review
Measurement of chronic pain in companion animals: Priorities for future research and development based on discussions from the Pain in Animals Workshop (PAW) 2017
[Review of ]. VETERINARY JOURNAL, 252.
author keywords: Cat; Chronic; Dog; Measurement; Pain; Research priorities
MeSH headings : Animals; Cats; Chronic Pain / diagnosis; Chronic Pain / veterinary; Dogs; Pain Management / veterinary; Research Design / trends; Veterinary Medicine / trends
TL;DR:
The estimation of long-standing pain in companion animals through the measurement of different dimensions impacted by pain is a fundamental requirement if pain management, and pain therapeutic development, are to advance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 15, 2020
2019 journal article
The effectiveness of marine based fatty acid compound (PCSO-524) and firocoxib in the treatment of canine osteoarthritis
BMC VETERINARY RESEARCH, 15(1).
author keywords: Osteoarthritis; Treatment; PCSO-524; NSAIDs; Firocoxib; Gait analysis; Dog
MeSH headings : 4-Butyrolactone / analogs & derivatives; 4-Butyrolactone / therapeutic use; Animals; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Dinoprostone / blood; Dog Diseases / drug therapy; Dogs; Double-Blind Method; Drug Therapy, Combination; Fatty Acids, Unsaturated / therapeutic use; Female; Gait / drug effects; Male; Osteoarthritis / complications; Osteoarthritis / drug therapy; Osteoarthritis / veterinary; Pain / drug therapy; Pain / etiology; Pain / veterinary; Pain Measurement / veterinary; Prospective Studies; Sulfones / therapeutic use
TL;DR:
Combined use of both PCSO-524 and firocoxib is suggested to be more effective in alleviation of inflammation and improvement of weight bearing ability when compared to the uses of either PCso-524 or firo Coxib alone.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 4, 2019
2018 journal article
Anti-nerve growth factor monoclonal antibodies for the control of pain in dogs and cats
Vet Rec, 184(1), 14.
MeSH headings : Animals; Antibodies, Monoclonal / therapeutic use; Cat Diseases / therapy; Cats; Dog Diseases / therapy; Dogs; Nerve Growth Factors / antagonists & inhibitors; Osteoarthritis / complications; Osteoarthritis / therapy; Osteoarthritis / veterinary; Pain / etiology; Pain / veterinary; Pain Management / veterinary; Randomized Controlled Trials as Topic
TL;DR:
The mechanism of action of NGF, the role of N GF in osteoarthritis, research in rodent OA models and the current status of the development of anti-NGF mAbs in humans are outlined.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 25, 2019
2018 journal article
Assessment of a novel nanoparticle hyperthermia therapy in a murine model of osteosarcoma
Vet Surg, 47(8), 1021–1030.
MeSH headings : Animals; Bone Neoplasms / therapy; Bone Neoplasms / veterinary; Disease Models, Animal; Dog Diseases / blood; Dog Diseases / therapy; Dogs; Female; Hyperthermia, Induced / veterinary; Mice; Mice, Inbred C3H; Monocytes / physiology; Nanoparticles; Osteosarcoma / therapy; Osteosarcoma / veterinary; Phenotype; Receptors, CXCR4 / genetics
TL;DR:
Enhancing monocyte/macrophage function in dogs with OS may enhance antitumor immunity and Nanoparticle hyperthermia therapy increased in vitro monocyte chemotaxis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 25, 2019
2018 journal article
Characterization of gene expression in naturally occurring feline degenerative joint disease-associated pain
The Veterinary Journal, 243, 42–47.
author keywords: Cat; Degenerative joint disease; Neurobiological signature; Osteoarthritis; Pain
MeSH headings : Animals; Cat Diseases / genetics; Cats; Female; Ganglia, Spinal / metabolism; Ganglia, Spinal / physiopathology; Gene Expression; Gene Expression Profiling; Lumbosacral Region / physiopathology; Male; Osteoarthritis, Spine / veterinary; Pain / genetics; Pain / veterinary; Spinal Cord Dorsal Horn / metabolism; Spinal Cord Dorsal Horn / physiopathology
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: February 11, 2019
2018 journal article
Clinical safety of robenacoxib (Onsior (TM)) in cats with chronic musculo-skeletal disorder or osteoarthritis
Journal of Veterinary Pharmacology and Therapeutics, 41, 159–160.
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
Content validation of a critical appraisal tool for reviewing analgesia studies (CATRAS) involving subjects incapable of self-reporting pain
Pain Rep, 3(4).
author keywords: Critical appraisal tool; Analgesia; Pain
TL;DR:
This 67-item critical appraisal tool may enable critical and quantitative assessment of the quality of individual analgesia trials involving subjects incapable of self-reporting pain for use in systematic reviews and meta-analysis studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 25, 2019
2018 journal article
Effect of sucralfate on gastric permeability in an ex vivo model of stress-related mucosal disease in dogs
Journal of Veterinary Internal Medicine, 32(2), 670–678.
author keywords: barrier function; stress ulcer; transepithelial electrical resistance; Ussing chamber
MeSH headings : Animals; Anti-Ulcer Agents / administration & dosage; Anti-Ulcer Agents / pharmacology; Dog Diseases / chemically induced; Dog Diseases / drug therapy; Dog Diseases / prevention & control; Dogs; Gastric Mucosa / drug effects; Gastric Mucosa / pathology; Hydrogen-Ion Concentration; In Vitro Techniques; Isotonic Solutions; Ringer's Solution; Stomach Ulcer / chemically induced; Stomach Ulcer / drug therapy; Stomach Ulcer / prevention & control; Stomach Ulcer / veterinary; Sucralfate / administration & dosage; Sucralfate / pharmacology
TL;DR:
Sorbitfate appeared effective at restoring defects in gastric barrier function induced by acid and accelerating repair of tissues subjected to acid in this model, suggesting that sucralfate could have utility for the treatment and prevention of SRMD in dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2018 journal article
Electrophysiological characterisation of central sensitisation in canine spontaneous osteoarthritis
PAIN, 159(11), 2318–2330.
author keywords: Central sensitisation; Diffuse noxious inhibitory controls; Dog; Nociceptive withdrawal reflex; Osteoarthritis
MeSH headings : Acepromazine / pharmacology; Animals; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Case-Control Studies; Central Nervous System Sensitization / drug effects; Central Nervous System Sensitization / physiology; Dogs; Dopamine Antagonists / pharmacology; Electromyography; Electrophysiological Phenomena / physiology; Evoked Potentials, Motor / drug effects; Evoked Potentials, Motor / physiology; Musculoskeletal Abnormalities / diagnosis; Musculoskeletal Abnormalities / etiology; Osteoarthritis / drug therapy; Osteoarthritis / physiopathology; Osteoarthritis / veterinary; Pain Threshold / drug effects; Pain Threshold / physiology; Reflex / drug effects; X-Rays
TL;DR:
Evidence of neurophysiological changes consistent with CS is provided in dogs with spontaneous OA and it is demonstrated that canine OA is associated with reduced DNIC.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 10, 2018
2018 journal article
Enrichment Preferences of FIV-Infected and Uninfected Laboratory-Housed Cats
Viruses, 10(7), 353.
author keywords: FIV; enrichment; welfare; feline; laboratory animal
MeSH headings : Animals; Animals, Laboratory; Cats; Feline Acquired Immunodeficiency Syndrome / virology; Immunodeficiency Virus, Feline / physiology
TL;DR:
Cats used in a longitudinal study of the effects of chronic feline immunodeficiency virus (FIV) infection were used and it was found that cats elected to be brushed, preferred social interaction and play with the laser to the ball, and preferred to scratch on an inclined-box toenail conditioning object compared to a horizontal, circular toenails conditioning object.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: October 16, 2018
2018 journal article
Evaluation of the effect of signalment and owner-reported impairment level on accelerometer-measured changes in activity in osteoarthritic dogs receiving a non-steroidal anti-inflammatory
VETERINARY JOURNAL, 242, 48–52.
author keywords: Accelerometer; Activity; Osteoarthritis; Non-steroidal anti-inflammatory; Pain
MeSH headings : Accelerometry / veterinary; Animals; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Chronic Pain / drug therapy; Chronic Pain / veterinary; Dog Diseases / drug therapy; Dog Diseases / physiopathology; Dogs; Female; Humans; Male; Osteoarthritis, Hip / drug therapy; Osteoarthritis, Hip / physiopathology; Osteoarthritis, Hip / veterinary; Pain Measurement / veterinary; Prospective Studies
TL;DR:
Evaluated the effect of signalment and initial impairment level on accelerometer-measured changes in activity in osteoarthritic dogs after receiving a non-steroidal anti-inflammatory (NSAID) treatment and found greater initial impairment was associated with larger positive changes inActivity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 31, 2018
2018 article
Face validity of a proposed tool for staging canine osteoarthritis: Canine OsteoArthritis Staging Tool (COAST)
Cachon, T., Frykman, O., Innes, J. F., Lascelles, B. D. X., Okumura, M., Sousa, P., … Van Ryssen, B. (2018, May). VETERINARY JOURNAL, Vol. 235, pp. 1–8.
MeSH headings : Animals; Behavior, Animal / physiology; Dog Diseases / diagnosis; Dog Diseases / pathology; Dog Diseases / physiopathology; Dogs; Genetic Predisposition to Disease; Orthopedics / methods; Orthopedics / veterinary; Osteoarthritis / pathology; Osteoarthritis / physiopathology; Osteoarthritis / veterinary; Pain / diagnosis; Pain / veterinary; Reproducibility of Results
TL;DR:
This paper presents a meta-analyses of the immune system’s response to chronic pain and its role in the development of central nervous system disorders.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2018 journal article
Face validity of a proposed tool for staging canine osteoarthritis: Canine OsteoArthritis Staging Tool (COAST)
Veterinary Journal (London, England: 1997), 235, 1–8.
Source: ORCID
Added: January 22, 2019
2018 journal article
Influence of gait on bone strength in turkeys with leg defects
Poult Sci, 97(8), 2621–2637.
author keywords: gait parameter; bone strength; turkey; leg defect; welfare; locomotion; BMD
MeSH headings : Animals; Biomechanical Phenomena; Bone Density; Gait; Hindlimb / abnormalities; Kinetics; Male; Tarsus, Animal; Turkeys / abnormalities; Turkeys / growth & development; Turkeys / physiology
TL;DR:
Only crooked toes caused consistent differences in gait patterns, bone properties and bone strength, but in general, gait kinetics was correlated with bone biomechanics in turkeys.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: January 25, 2019
2018 journal article
Initial evaluation of PetPace activity monitor
Vet J, 237, 63–68.
author keywords: Activity; Accelerometer; Dog; Monitor; Osteoarthritis
MeSH headings : Accelerometry / instrumentation; Accelerometry / methods; Accelerometry / standards; Accelerometry / veterinary; Actigraphy / instrumentation; Actigraphy / methods; Actigraphy / standards; Actigraphy / veterinary; Animals; Back; Dogs / physiology; Humans; Monitoring, Physiologic / methods; Monitoring, Physiologic / veterinary; Motor Activity / physiology; Quality of Life; Veterinarians
TL;DR:
PetPace has a moderate correlation with the most validated activity monitor that has been used in veterinary medicine, and its real-time data acquisition, user friendly interface for owners and cost make this device an attractive tool for monitoring activity in dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 25, 2019
2018 conference paper
Investigation of Sensory Thresholds in Cavalier King Charles Spaniels with and without Chiari-like Malformations and Syringomyelia
Pain in Animals Workshop 2017: Abstracts. Presented at the Pain in Animals Workshop 2017: Abstracts.
Event: Pain in Animals Workshop 2017: Abstracts
Sources: Crossref, NC State University Libraries
Added: January 25, 2020
2018 journal article
Investigation of sensory thresholds in Cavalier King Charles Spaniels with and without Chiari-like malformations and syringomyelia
Journal of Veterinary Internal Medicine, 32(6), 2021–2028.
author keywords: neuropathic pain; paresthesia; phantom scratch; syrinx
MeSH headings : Animals; Brain / diagnostic imaging; Brain / physiopathology; Budd-Chiari Syndrome / diagnostic imaging; Budd-Chiari Syndrome / physiopathology; Budd-Chiari Syndrome / veterinary; Case-Control Studies; Dog Diseases / diagnostic imaging; Dog Diseases / physiopathology; Dogs; Female; Hypesthesia / physiopathology; Hypesthesia / veterinary; Magnetic Resonance Imaging / veterinary; Male; Neuroimaging / veterinary; Sensory Thresholds / physiology; Syringomyelia / diagnostic imaging; Syringomyelia / physiopathology; Syringomyelia / veterinary
TL;DR:
Mechanical and thermal sensitivity does not appear to be related to the presence of SM, but mechanical sensitivity appears to berelated to the existence of pain and clinical signs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: December 31, 2018
2018 journal article
Measuring Distance Traveled with an Activity Monitor in Normal Dogs Participating in a 5K Race
Veterinary and Comparative Orthopaedics and Traumatology, 31(S 02), A1–A25.
Sources: Crossref, NC State University Libraries
Added: January 25, 2020
2018 chapter
Oral tumours
In J. Dobson & B. D. X. Lascelles (Eds.), BSAVA Manual of Oncology (3rd ed., pp. 191–201).
Ed(s): J. Dobson & B. Lascelles
Sources: NC State University Libraries, NC State University Libraries
Added: January 25, 2019
2018 conference paper
Pilot Evaluation of The Effect of Anti-nerve Growth Factor Antibody on Sensory System Function in Dogs with Degenerative Joint Disease-Associated Pain
Pain in Animals Workshop 2017: Abstracts. Presented at the Pain in Animals Workshop 2017: Abstracts.
Event: Pain in Animals Workshop 2017: Abstracts
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 25, 2020
2018 journal article
Pilot study evaluating the effect of feeding method on overall activity of neutered indoor pet cats
Journal of Veterinary Behavior, 25, 9–13.
author keywords: cat behavior; obesity; feeding method; activity; indoor
TL;DR:
Although the type of feeding method in this pilot study did not affect overall activity, providing meals to cats using food toys may provide other benefits related to satiety, stress reduction, and overall well‐being.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 29, 2019
2018 journal article
Prescribing Practices of Veterinarians in the Treatment of Chronic Musculoskeletal Pain in Cats
J Feline Med Surg, 7(6), 495–506.
author keywords: Musculoskeletal pain; analgesics; surveys; questionnaires
MeSH headings : Animals; Cat Diseases / drug therapy; Cats; Cross-Sectional Studies; Musculoskeletal Pain / drug therapy; Musculoskeletal Pain / veterinary; Practice Patterns, Physicians' / statistics & numerical data; Surveys and Questionnaires; Veterinarians / statistics & numerical data
TL;DR:
The results show a contrast between therapies prescribed by practitioners and what is supported by evidenced-based literature, and future research evaluating the safety and efficacy of gabapentin should be prioritised.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 25, 2019
2018 chapter
Principles of oncological surgery
In J. Dobson & B. D. X. Lascelles (Eds.), BSAVA Manual of Oncology (3rd ed., pp. 44–59).
Ed(s): J. Dobson & B. Lascelles
Sources: NC State University Libraries, NC State University Libraries
Added: January 25, 2019
2018 journal article
Quantitative sensory testing in dogs with painful disease: A window to pain mechanisms?
VETERINARY JOURNAL, 243, 33–41.
author keywords: Algoplasticity; Dog; Quantitative sensory testing
MeSH headings : Animals; Dog Diseases / diagnosis; Dog Diseases / etiology; Dogs; Pain / diagnosis; Pain / etiology; Pain / veterinary; Pain Measurement / instrumentation; Pain Measurement / methods; Pain Measurement / veterinary; Pain Threshold
TL;DR:
A narrative review describes the investigations into QST in clinical populations of dogs to date, and discusses the potential benefits and limitations of such testing.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 11, 2019
2018 journal article
Randomized Pilot Trial of the Effects of an Egg-Shell Membrane-Based Supplement (Movoflextm) on Mobility and Serum Biomarkers of Inflammation in Dogs with Osteoarthritis
Veterinary and Comparative Orthopaedics and Traumatology, 31(S 02), A1–A25.
Sources: Crossref, NC State University Libraries, ORCID
Added: December 3, 2019
2018 journal article
Replicate effects and test-retest reliability of quantitative sensory threshold testing in dogs with and without chronic pain
Veterinary Anaesthesia and Analgesia, 44(3), 615–624.
Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: August 6, 2018
2018 conference paper
Reverse Translation to Discover Relevant Targets for Chronic Pain: GFRA3/Artemin
Pain in Animals Workshop 2017: Abstracts. Presented at the Pain in Animals Workshop 2017: Abstracts.
Event: Pain in Animals Workshop 2017: Abstracts
Sources: Crossref, NC State University Libraries
Added: January 25, 2020
2018 journal article
Spontaneous painful disease in companion animals can facilitate the development of chronic pain therapies for humans
Osteoarthritis and Cartilage, 26(2), 175–183.
Source: ORCID
Added: January 22, 2019
2018 journal article
The Effectiveness of Marine-Based Fatty Acid Compound (PCSO-524) Alone and Combined with Previcox in the Treatment of Canine Osteoarthritis
Veterinary and Comparative Orthopaedics and Traumatology, 31(S 02), A1–A25.
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 25, 2020
2018 journal article
The pharmacokinetics and analgesic effects of extended-release buprenorphine administered subcutaneously in healthy dogs
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 41(4), 502–512.
author keywords: buprenorphine; dog; extended-release; pharmacodynamics; pharmacokinetics
MeSH headings : Analgesia / methods; Analgesia / veterinary; Analgesics, Opioid / administration & dosage; Analgesics, Opioid / blood; Analgesics, Opioid / pharmacokinetics; Analgesics, Opioid / pharmacology; Animals; Buprenorphine / administration & dosage; Buprenorphine / blood; Buprenorphine / pharmacokinetics; Buprenorphine / pharmacology; Delayed-Action Preparations; Dogs; Female; Injections, Subcutaneous / veterinary; Male
TL;DR:
Results showed that ER-buprenorphine administered at a dose of 0.2 mg/kg resulted in prolonged and sustained plasma concentrations and antinociceptive effects up to 72 hr after drug administration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2018 journal article
The pharmacokinetics of gabapentin in cats
JOURNAL OF VETERINARY INTERNAL MEDICINE, 32(6), 1996–2002.
author keywords: compounded; feline; pain; transdermal
MeSH headings : Analgesics / administration & dosage; Analgesics / blood; Analgesics / pharmacokinetics; Animals; Cats / metabolism; Female; Gabapentin / administration & dosage; Gabapentin / blood; Gabapentin / pharmacokinetics; Half-Life; Injections, Intravenous / veterinary; Male
TL;DR:
Repeated oral dosing of gabapentin did not alter the drug's pharmacokinetics, making dose adjustments unnecessary with long‐term treatment, and the transdermal route is an inappropriate choice for drug administration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 31, 2018
2018 conference paper
Translation of Activity Monitoring in Normal Dogs Towards Distance Travelled
Pain in Animals Workshop 2017: Abstracts. Presented at the Pain in Animals Workshop 2017: Abstracts.
Event: Pain in Animals Workshop 2017: Abstracts
Sources: Crossref, NC State University Libraries
Added: January 25, 2020
2018 chapter
Tumours of the respiratory system and thoracic cavity
In J. Dobson & B. D. X. Lascelles (Eds.), BSAVA Manual of Canine and Feline Oncology (3rd ed., pp. 265–284).
Ed(s): J. Dobson & B. Lascelles
TL;DR:
This chapter looks at tumours of the nasal planum, which are known to cause cancer of the nose and nasal cavity, and mesothelioma, which is a type of tumour found in the chest wall of the heart.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: January 25, 2019
2018 chapter
Tumours of the small intestines
In J. Dobson & B. D. X. Lascelles (Eds.), BSAVA Manual of Oncology (3rd ed., pp. 212–215).
Ed(s): J. Dobson & B. Lascelles
TL;DR:
This chapter covers presentation and clinical signs; clinical approach; management; prognosis of intestinal tumours in small animals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: January 25, 2019
2017 journal article
Assessment and Recognition of Chronic (Maladaptive) Pain
Feline Anesthesia and Pain Management, 241–256.
Source: ORCID
Added: January 22, 2019
2017 journal article
Caregiver placebo effect in analgesic clinical trials for cats with naturally occurring degenerative joint disease-associated pain
Veterinary Record, 180(19), 473–473.
MeSH headings : Analgesics / therapeutic use; Animals; Caregivers / psychology; Cat Diseases / drug therapy; Cats; Female; Humans; Joint Diseases / complications; Joint Diseases / veterinary; Male; Optimism; Osteoarthritis / complications; Osteoarthritis / veterinary; Pain / drug therapy; Pain / etiology; Pain / veterinary; Placebo Effect; Treatment Outcome
TL;DR:
The caregiver placebo effect across these clinical trials was remarkably high, making demonstration of efficacy for an analgesic above a placebo difficult, and further work is needed to determine whether a potential placebo-by-proxy effect could benefit cats in clinical settings.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2017 journal article
Chronic maladaptive pain in cats: A review of current and future drug treatment options
The Veterinary Journal, 230, 52–61.
author keywords: Maladaptive pain; Cats; Analgesia; Central plasticity; Chronic pain
MeSH headings : Analgesics / therapeutic use; Animals; Cat Diseases / diagnosis; Cat Diseases / drug therapy; Cats; Chronic Pain / diagnosis; Chronic Pain / drug therapy; Chronic Pain / veterinary; Forecasting; Pain Management / trends; Pain Management / veterinary; Pain Measurement / veterinary
TL;DR:
The current understanding of chronic or maladaptive pain, techniques for the detection and measurement of the condition and the associated central nervous changes, as well as an overview of the data evaluating potential therapeutics in cats are detailed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: January 22, 2019
2017 journal article
Defining local nerve blocks for feline distal pelvic limb surgery: a cadaveric study
JOURNAL OF FELINE MEDICINE AND SURGERY, 19(12), 1215–1223.
MeSH headings : Anesthetics, Local / administration & dosage; Animals; Cadaver; Cats / anatomy & histology; Female; Hindlimb / innervation; Hindlimb / surgery; Male; Methylene Blue / analogs & derivatives; Nerve Block / methods; Nerve Block / veterinary; Peroneal Nerve / anatomy & histology
TL;DR:
These two, three-point injection methods may be an effective perioperative analgesia technique for feline distal pelvic limb procedures.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2017 journal article
Development and preliminary validity and reliability of the montreal instrument for cat arthritis testing, for use by caretaker/owner, MI-CAT(C), via a randomised clinical trial
Applied Animal Behaviour Science, 200, 96–105.
author keywords: Behaviour; Degenerative joint disease/osteoarthritis; Pain measurement; Quality of life; Cats; NSAID
TL;DR:
A randomised, double-blinded, placebo-controlled, crossover clinical trial was conducted, and meloxicam efficacy in 54 OA-affected cats was evaluated using the MI-CAT(C)-v2 and locomotor activity monitoring (AM).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2017 journal article
Distinct neuronal populations in the basolateral and central amygdala are activated with acute pain, conditioned fear, and fear-conditioned analgesia
NEUROSCIENCE LETTERS, 661, 11–17.
author keywords: Nociception; Contextual fear; Fear-conditioned analgesia; Amygdala; cFos; Neural circuits
MeSH headings : Acute Pain / physiopathology; Amygdala / physiopathology; Analgesia / methods; Animals; Central Amygdaloid Nucleus / metabolism; Conditioning, Psychological / physiology; Fear / physiology; Male; Mice, Inbred C57BL; Neurons / metabolism; Pain Management; Periaqueductal Gray / metabolism; Periaqueductal Gray / physiopathology
TL;DR:
The results show that amygdala processing of conditioned contextual aversive, nociceptive, and FCA behaviors involve different neuronal phenotypes and neural circuits between, within, and from various amygdala nuclei.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2017 journal article
Evaluation of interobserver agreement for postoperative pain and sedation assessment in cats
Journal of the American Veterinary Medical Association, 251(5), 544–551.
MeSH headings : Analgesia; Animals; Bupivacaine; Buprenorphine; Cats / surgery; Female; Hysterectomy / veterinary; Observer Variation; Ovariectomy / veterinary; Pain Measurement / veterinary; Pain, Postoperative / diagnosis; Pathologists / psychology; Reproducibility of Results
TL;DR:
Interobserver differences in assessing pain can lead to different conclusions regarding treatment effectiveness, and interobserver agreements for pain scores were good, and that for sedation scores was fair.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: January 22, 2019
2017 journal article
Gait parameters in four strains of turkeys and correlations with bone strength
Poultry Science, 96(7), 1989–2005.
Source: ORCID
Added: January 22, 2019
2017 journal article
Generation of a stable transgenic swine model expressing a porcine histone 2b-egfp fusion protein for cell tracking and chromosome dynamics studies
PLoS One, 12(1).
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
Nocifensive Behaviors in Mice with Radiation-Induced Oral Mucositis
RADIATION RESEARCH, 187(3), 397–403.
MeSH headings : Animals; Behavior, Animal / radiation effects; Mice; Neurons / pathology; Neurons / radiation effects; Nociception / radiation effects; Radiation Injuries, Experimental / pathology; Radiation Injuries, Experimental / physiopathology; Stomatitis / pathology; Stomatitis / physiopathology; Trigeminal Ganglion / pathology
TL;DR:
Data validate an appropriate model for cancer treatment related discomfort in humans and quantify resultant discomfort, and characterize peripheral sensitization following radiation-induced glossitis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2017 journal article
Pharmacokinetics and pharmacodynamics of an extended-release buprenorphine formulation in dogs
Veterinary Anaesthesia and Analgesia, 44(1), 195.e6.
Sources: Crossref, ORCID
Added: January 22, 2019
2017 journal article
Pharmacokinetics of liposomal encapsulated buprenorphine suspension following subcutaneous administration to cats
Journal of Veterinary Pharmacology and Therapeutics, 40(3), 256–269.
Source: ORCID
Added: January 22, 2019
2017 journal article
Pilot evaluation of a novel unilateral onychectomy model and efficacy of an extended release buprenorphine product
BMC Veterinary Research, 13.
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
Quality assurance and best research practices for non-regulated veterinary clinical studies
BMC VETERINARY RESEARCH, 13.
MeSH headings : Animals; Clinical Trials as Topic / veterinary; Practice Guidelines as Topic / standards; Quality Control; Reproducibility of Results; Research Design / standards
TL;DR:
The purpose of this first of a series of statement papers is to outline and reference specific quality control and quality assurance procedures that should, at least in part, be incorporated into all veterinary clinical studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2017 journal article
Questionnaire-based Analysis of Owner-reported Scratching and Pain Signs in Cavalier King Charles Spaniels Screened for Chiari-like Malformation and Syringomyelia
Journal of Veterinary Internal Medicine, 32(1), 331–339.
author keywords: Neuropathic pain; Paresthesia; Phantom scratch; Syrinx
MeSH headings : Animals; Arnold-Chiari Malformation / diagnostic imaging; Arnold-Chiari Malformation / pathology; Arnold-Chiari Malformation / veterinary; Dog Diseases / diagnosis; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Dogs; Female; Magnetic Resonance Imaging / veterinary; Male; Neuroimaging / veterinary; Pain / pathology; Pain / veterinary; Pruritus / pathology; Pruritus / veterinary; Surveys and Questionnaires; Syringomyelia / diagnostic imaging; Syringomyelia / pathology; Syringomyelia / veterinary
TL;DR:
Lack of association of owner‐reported signs with SM highlights the lack of understanding of the pathophysiology of pain in this disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2017 journal article
Repeatability and accuracy testing of a weight distribution platform and comparison to a pressure sensitive walkway to assess static weight distribution
VETERINARY AND COMPARATIVE ORTHOPAEDICS AND TRAUMATOLOGY, 30(2), 160–164.
author keywords: Pressure sensitive walkway; static weight distribution; weight distribution platform; repeatability
MeSH headings : Animals; Body Weight; Dogs / physiology; Posture; Pressure; Reproducibility of Results; Veterinary Medicine / instrumentation; Walking / physiology
TL;DR:
The weight distribution platform is a repeatable and accessible device to measure static weight distribution, and if proven the same in a clinical setting, it will be a valuable addition to current objective measures of limb use.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2017 journal article
Replicate effects and test–retest reliability of quantitative sensory threshold testing in dogs with and without chronic pain
Veterinary Anaesthesia and Analgesia, 44(3), 615–624.
author keywords: central sensitization; chronic pain; dogs; quantitative sensory testing; replicate effect
MeSH headings : Animals; Chronic Pain / physiopathology; Chronic Pain / veterinary; Cold Temperature; Dog Diseases / physiopathology; Dogs; Hot Temperature; Osteoarthritis / physiopathology; Osteoarthritis / veterinary; Pain Measurement; Pain Threshold / physiology; Pressure; Prospective Studies; Reproducibility of Results; Sensory Thresholds / physiology
TL;DR:
Evaluated replicate effects and test-retest reliability of mechanical and thermal quantitative sensory testing (QST) in normal dogs and dogs with osteoarthritis-associated pain showed variability over time, particularly for EVF and hot thermal stimuli.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: June 30, 2019
2017 review
Spontaneous painful disease in companion animals can facilitate the development of chronic pain therapies for humans
[Review of ]. OSTEOARTHRITIS AND CARTILAGE, 26(2), 175–183.
author keywords: Osteoarthritis; Pain; Model; Spontaneous disease; Dog; Cat
MeSH headings : Animals; Arthritis, Experimental / drug therapy; Chronic Pain / drug therapy; Chronic Pain / veterinary; Drug Development / methods; Humans; Osteoarthritis / drug therapy; Osteoarthritis / veterinary; Pain Management / methods; Pets; Translational Research, Biomedical / methods
TL;DR:
The role that spontaneous osteoarthritis in companion animals can play in translational research and therapeutic pharmacological development is outlined and the opportunity for target discovery exists but is, as yet, unproven.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2017 journal article
The use of functional data analysis to evaluate activity in a spontaneous model of degenerative joint disease associated pain in cats
PloS One, 12(1), e0169576.
Source: ORCID
Added: January 22, 2019
2017 review
Translational pain assessment: could natural animal models be the missing link?
[Review of ]. PAIN, 158(9), 1633–1646.
author keywords: Preclinical animal models; Natural; Experimental; Validity; Applicability; Translation
MeSH headings : Analgesics / therapeutic use; Animals; Dogs; Gray Matter / diagnostic imaging; Humans; Magnetic Resonance Imaging; Male; Models, Animal; Osteoarthritis / complications; Osteoarthritis / diagnosis; Osteoarthritis / veterinary; Pain / diagnosis; Pain / drug therapy; Pain / etiology; Pain / veterinary; Pain Measurement / methods; Translational Research, Biomedical / methods
TL;DR:
This review describes numerous conditions similarly applicable to pain research, with potential mutual benefits for human and veterinary clinicians, and their respective patients.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2017 journal article
Translational pain assessment: could natural animal models be the missing link?
Pain, 158(9), 1633–1646.
Source: ORCID
Added: January 22, 2019
2017 journal article
Validated Outcomes Measures for Canine Osteoarthritis
Vet Surg, 46(3), 341–342.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: January 22, 2019
2016 journal article
A Feline-Specific Anti-Nerve Growth Factor Antibody Improves Mobility in Cats with Degenerative Joint Disease-Associated Pain: A Pilot Proof of Concept Study
Journal of Veterinary Internal Medicine, 30(4), 1138–1148.
author keywords: Client-specific outcome measures; Feline musculoskeletal pain index; Osteoarthritis
MeSH headings : Analgesics, Non-Narcotic / therapeutic use; Animals; Antibodies, Monoclonal / therapeutic use; Cat Diseases / therapy; Cats; Double-Blind Method; Female; Injections, Subcutaneous / veterinary; Lameness, Animal / therapy; Male; Nerve Growth Factor / immunology; Osteoporosis / therapy; Osteoporosis / veterinary; Pain, Intractable / therapy; Pain, Intractable / veterinary; Pilot Projects; Species Specificity; Treatment Outcome
TL;DR:
A 6‐week duration positive analgesic effect of this fully felinized anti‐NGF antibody in cats suffering from DJD‐associated pain is demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2016 journal article
A comparison of serum and plasma cytokine values using a multiplexed assay in cats
Veterinary Immunology and Immunopathology, 182, 69–73.
author keywords: Biomarker; Immunoassay; Feline
MeSH headings : Animals; Biomarkers / blood; Blood Chemical Analysis / methods; Cats / blood; Cats / immunology; Cytokines / blood; Immunoassay / methods; Plasma / immunology
TL;DR:
While serum and plasma agreement was generally good, detection was improved using serum samples, and alterations of cytokine concentrations have been associated with joint deterioration and pain in humans, similar changes have not been investigated in cats.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2016 journal article
A data-driven weighting scheme for multivariate phenotypic endpoints recapitulates zebrafish developmental cascades
TOXICOLOGY AND APPLIED PHARMACOLOGY, 314, 109–117.
Contributors: G. Zhang n, K. Roell n, L. Truong *, R. Tanguay * & D. Reif n
author keywords: Zebrafish; High-dimensional; Bayesian; Developmental cascade; ToxRefDB; Risk assessment; Multiple endpoints; Multivariate; Scoring
MeSH headings : Animals; Models, Theoretical; Multivariate Analysis; Phenotype; Zebrafish / embryology
TL;DR:
The results suggest that developmental cascade effects triggered by chemical exposure can be recapitulated by analyzing the relationships among endpoints, and wAggE offers a powerful approach for analysis of multivariate phenotypes that can reveal underlying etiological processes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 review
Aging in cats: Common physical and functional changes
[Review of ]. JOURNAL OF FELINE MEDICINE AND SURGERY, 18(7), 533–550.
MeSH headings : Aging; Animals; Cats / physiology; Physical Examination / veterinary
TL;DR:
A thorough, systems-based overview of common health-related changes observed in cats as they age is provided, drawing on expert opinion and available data in both the cat and other species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
Aging in cats: Common physical and functional changes
Journal of Feline Medicine and Surgery, 18(7), 533–550.
Source: ORCID
Added: January 22, 2019
2016 journal article
Alfaxalone Anaesthesia Facilitates Electrophysiological Recordings of Nociceptive Withdrawal Reflexes in Dogs (Canis familiaris)
PLOS ONE, 11(7).
MeSH headings : Anesthesia / methods; Anesthetics / administration & dosage; Animals; Consciousness / drug effects; Dogs; Electrophysiological Phenomena; Male; Osteoarthritis / diagnosis; Osteoarthritis / physiopathology; Osteoarthritis / veterinary; Pain / diagnosis; Pain / drug therapy; Pain / veterinary; Pregnanediones / administration & dosage; Reflex / drug effects
TL;DR:
Development of a suitable anaesthetic protocol in experimental dogs, which facilitated electrophysiological nociceptive withdrawal reflex assessment, may increase the acceptability of using the technique in owned dogs with naturally occurring osteoarthritis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 review
An extended release local anaesthetic: potential for future use in veterinary surgical patients?
[Review of ]. VETERINARY MEDICINE AND SCIENCE, 2(4), 229–238.
author keywords: bupivacaine liposome injectable suspension; pain; perioperative; dog
TL;DR:
There is a clear unmet need for a long‐acting local anaesthetic that can be added to the multimodal analgesic protocol to provide pain relief to patients in the home environment or during extended hospitalization.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
Association of Canine Osteosarcoma and Monocyte Phenotype and Chemotactic Function
Journal of Veterinary Internal Medicine, 30(4), 1167–1178.
author keywords: Bone tumor; Chemoreceptors; Chemotaxis; Immunoregulation
MeSH headings : Animals; Bone Neoplasms / blood; Bone Neoplasms / veterinary; Case-Control Studies; Chemotaxis; Cytokines / metabolism; Disease-Free Survival; Dog Diseases / blood; Dogs; Female; Flow Cytometry / veterinary; Gene Expression Regulation; Male; Monocytes / metabolism; Monocytes / physiology; Osteosarcoma / blood; Osteosarcoma / veterinary; RNA, Messenger / analysis
TL;DR:
Dogs with OSA have decreased monocyte chemokine receptor expression and monocytes chemotaxis, potential mechanisms by which OSA might evade the immune response, and reversal of monocyte dysfunction using immunotherapy could improve survival in dogs with Osa.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2016 journal article
Attitudes of small animal practitioners toward participation in veterinary clinical trials
Journal of the American Veterinary Medical Association, 250(1), 86–97.
MeSH headings : Animals; Attitude of Health Personnel; Clinical Trials as Topic / veterinary; Cross-Sectional Studies; Data Collection; Humans; Pets; Research / organization & administration; Veterinarians; Veterinary Medicine / methods
TL;DR:
Attitudes of small animal practitioners toward veterinary clinical trials and variables influencing their likelihood of participating in such trials were determined and efforts should be increased to raise practitioner awareness of clinical trials for which patients might qualify.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018
2016 journal article
Clinical metrology instrument administration: evaluation of baseline variability and the effect of independent versus dependent interviewing on pain and mobility scores in dogs with osteoarthritis.
Journal of Veterinary Internal Medicine, 30(3), 836–846.
Source: NC State University Libraries
Added: September 8, 2019
2016 journal article
Clinical safety of robenacoxib in feline osteoarthritis: results of a randomized, blinded, placebo-controlled clinical trial
Journal of Feline Medicine and Surgery, 18(8), 632–642.
Source: ORCID
Added: January 22, 2019
2016 journal article
Comparison of thermal and mechanical quantitative sensory testing in client-owned dogs with chronic naturally occurring pain and normal dogs
The Veterinary Journal, 210, 95–97.
Contributors: M. Freire n, D. Knazovicky n , B. Case n, A. Thomson n & B. Lascelles n
author keywords: Canine; Central Sensitization; Chronic pain; Mechanical sensory threshold; Thermal sensory threshold
MeSH headings : Animals; Central Nervous System Sensitization; Dog Diseases / physiopathology; Dogs; Osteoarthritis / physiopathology; Osteoarthritis / veterinary; Pain / physiopathology; Pain / veterinary; Sensory Thresholds
TL;DR:
Whether QST is different between dogs with chronic pain and normal dogs needs further investigation using a larger group of animals and age, weight and sex matched groups.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, ORCID
Added: January 22, 2019
2016 journal article
Do cats with a cranial cruciate ligament injury and osteoarthritis demonstrate a different gait pattern and behavior compared to sound cats?
Acta Vet Scand, 58(Suppl 1).
author keywords: Feline; Cranial cruciate ligament; Pain questionnaire; Owner assessment; Pressure mat technique
MeSH headings : Animals; Anterior Cruciate Ligament Injuries / complications; Anterior Cruciate Ligament Injuries / veterinary; Behavior, Animal / physiology; Cat Diseases / etiology; Cat Diseases / pathology; Cats; Female; Gait / physiology; Humans; Lameness, Animal / etiology; Male; Osteoarthritis / complications; Osteoarthritis / veterinary; Surveys and Questionnaires
TL;DR:
It is indicated that cats with a previous CCL injury put less weight, on the affected hindlimb but for a longer time, and improved assessment tools for chronic pain caused by OA in cats are needed, both to facilitate diagnosis and to evaluate pain-relieving treatment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2016 journal article
Dolor articular en perros y gatos domésticos
Source: ORCID
Added: January 22, 2019
2016 journal article
Douleur articulaire chez les chiens et chats
Source: ORCID
Added: January 22, 2019
2016 review
Evaluating aging in cats: How to determine what is healthy and what is disease
[Review of ]. JOURNAL OF FELINE MEDICINE AND SURGERY, 18(7), 551–570.
MeSH headings : Aging; Animals; Cat Diseases / diagnosis; Cat Diseases / physiopathology; Cats / physiology; Physical Examination / veterinary; Quality of Life
TL;DR:
This second review proposes criteria for assessing ‘healthy aged cats’ and draws on expert opinion and available data in both the cat and other species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
Evaluating aging in cats: How to determine what is healthy and what is disease
Journal of Feline Medicine and Surgery, 18(7), 551–570.
Source: ORCID
Added: January 22, 2019
2016 journal article
Evaluation of Clinical Metrology Instrument in Dogs with Osteoarthritis
Journal of Veterinary Internal Medicine, 30(3), 836–846.
author keywords: Analgesia; Client metrology instrument; Degenerative joint disease; Questionnaire
MeSH headings : Animals; Antibodies / immunology; Antibodies / therapeutic use; Dog Diseases / immunology; Dog Diseases / physiopathology; Dog Diseases / therapy; Dogs; Double-Blind Method; Immunotherapy / veterinary; Nerve Growth Factor / immunology; Osteoarthritis / physiopathology; Osteoarthritis / therapy; Osteoarthritis / veterinary; Pain / drug therapy; Pain / veterinary; Pain Measurement / veterinary; Pilot Projects; Proof of Concept Study
TL;DR:
There is little difference between independent and dependent interviewing, however, dependent interviewing resulted in increased treatment effect sizes and investigators could increase clinical trial power through minimal change to study design.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2016 journal article
Evaluation of serum cytokines in cats with and without degenerative joint disease and associated pain
Veterinary Immunology and Immunopathology, 183, 49–59.
author keywords: Biomarker; Immunoassay; Multiplex; Arthritis
MeSH headings : Animals; Cat Diseases / blood; Cat Diseases / physiopathology; Cats; Cytokines / blood; Female; Male; Osteoarthritis / blood; Osteoarthritis / diagnostic imaging; Osteoarthritis / physiopathology; Osteoarthritis / veterinary; Pain / veterinary; Radiography / veterinary
TL;DR:
Evaluating the concentration of cytokines and chemokines in serum samples obtained from cats with and without degenerative joint disease and associated pain showed that cats with higher radiographic degenerative joints disease scores have higher serum concentrations of IL-4 and IL-8, while Cats with higher orthopedic exam pain scores haveHigher concentrations ofIL-8.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: January 22, 2019
2016 journal article
Functional outcome measures in a surgical model of hip osteoarthritis in dogs
Journal of Experimental Orthopaedics, 3(1), 17.
Source: ORCID
Added: January 22, 2019
2016 journal article
In Vitro and In Vivo Characterization of a Fully Felinized Therapeutic Anti-Nerve Growth Factor Monoclonal Antibody for the Treatment of Pain in Cats
JOURNAL OF VETERINARY INTERNAL MEDICINE, 30(4), 1129–1137.
author keywords: Cat pain; Companion animals; Feline analgesia; PETization; Pharmacokinetics
MeSH headings : Analgesics, Non-Narcotic / pharmacokinetics; Analgesics, Non-Narcotic / therapeutic use; Animals; Antibodies, Monoclonal / pharmacokinetics; Antibodies, Monoclonal / therapeutic use; Cat Diseases / therapy; Cats; Female; Lameness, Animal / therapy; Male; Nerve Growth Factor / immunology; Osteoarthritis / therapy; Osteoarthritis / veterinary; Pain Management / veterinary; Pain, Intractable / therapy; Pain, Intractable / veterinary; Species Specificity; Treatment Outcome
TL;DR:
The high affinity, long plasma half‐life, safety, and analgesic efficacy of felinized anti‐NGF mAb (NV‐02) support further investigation of the analgesic potential of this antibody in the cat.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
In vitro and in vivo characterization of a fully felinized therapeutic anti-nerve growth factor monoclonal antibody for the treatment of pain in cats
Journal of Veterinary Internal Medicine, 30(4), 1129–1137.
Source: ORCID
Added: January 22, 2019
2016 journal article
Joint Pain in Pet Dogs and Cats
Source: ORCID
Added: January 22, 2019
2016 journal article
Mechanical and Thermal Sensory Testing in Normal Chondrodystrophoid Dogs and Dogs with Spinal Cord Injury caused by Thoracolumbar Intervertebral Disc Herniations
Journal of Veterinary Internal Medicine, 30(2), 627–635.
Contributors: A. Gorney n, S. Blau n, C. Dohse n, E. Griffith n, K. Williams n, J. Lim n, D. Knazovicky n , B. Lascelles n, N. Olby n
author keywords: Allodynia; Mechanical threshold; Nociception; Quantitative sensory testing; Thermal threshold
MeSH headings : Animals; Cold Temperature; Dog Diseases / diagnosis; Dogs; Female; Hot Temperature; Intervertebral Disc Displacement / diagnosis; Intervertebral Disc Displacement / veterinary; Male; Pressure; Sensory Thresholds / physiology; Spinal Cord Injuries / diagnosis; Spinal Cord Injuries / veterinary
TL;DR:
The differences in sensation among neurologic grades indicate that these techniques can be used to further characterize recovery of SCI dogs and can be measured reliably in chondrodystrophoid dogs and are altered by SCI.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2016 journal article
Pharmacokinetics of bupivacaine after intraperitoneal administration to cats undergoing ovariohysterectomy
AMERICAN JOURNAL OF VETERINARY RESEARCH, 77(6), 641–645.
MeSH headings : Anesthesia / veterinary; Anesthetics, Local / administration & dosage; Anesthetics, Local / blood; Anesthetics, Local / pharmacokinetics; Anesthetics, Local / pharmacology; Animals; Biological Availability; Bupivacaine / administration & dosage; Bupivacaine / blood; Bupivacaine / pharmacokinetics; Bupivacaine / pharmacology; Buprenorphine / administration & dosage; Cats / blood; Female; Half-Life; Hysterectomy / veterinary; Isoflurane; Meloxicam; Ovariectomy / veterinary; Propofol; Thiazines; Thiazoles
TL;DR:
Intraperitoneal administration of bupivacaine resulted in concentrations that did not cause observable toxicosis and studies to investigate analgesic effects for this technique in cats are warranted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
Pilot evaluation of a novel unilateral onychectomy model and efficacy of an extended release buprenorphine product
BMC Veterinary Research, 13(1), 32.
Source: ORCID
Added: January 22, 2019
2016 journal article
Pilot, randomized, placebo-controlled clinical field study to evaluate the effectiveness of bupivacaine liposome injectable suspension for the provision of post-surgical analgesia in dogs undergoing stifle surgery
BMC Veterinary Research, 12(1).
author keywords: Bupivacaine liposome injectable suspension; Dog; Pain; Cruciate surgery
MeSH headings : Analgesia / veterinary; Anesthetics, Local / administration & dosage; Anesthetics, Local / pharmacology; Animals; Bupivacaine / administration & dosage; Bupivacaine / pharmacology; Dog Diseases / surgery; Dogs; Female; Liposomes; Male; Pain, Postoperative / prevention & control; Pain, Postoperative / veterinary; Pilot Projects; Stifle / surgery
TL;DR:
AT-003 (bupivacaine liposome injectable suspension) provided measurable local analgesia over a 72-h period following post-stifle surgery surgical site tissue infiltration.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2016 journal article
Severity of Nasal Inflammatory Disease Questionnaire for Canine Idiopathic Rhinitis Control: Instrument Development and Initial Validity Evidence
JOURNAL OF VETERINARY INTERNAL MEDICINE, 31(1), 134–141.
author keywords: Lymphoplasmacytic; Psychometrics; Survey
MeSH headings : Animals; Case-Control Studies; Dog Diseases / prevention & control; Dogs; Female; Humans; Male; Ownership; Pain, Intractable / prevention & control; Pain, Intractable / veterinary; Quality of Life; Reproducibility of Results; Rhinitis / prevention & control; Rhinitis / veterinary; Severity of Illness Index; Surveys and Questionnaires; Symptom Assessment
TL;DR:
The SNIFLD questionnaire provides a mechanism for repeated assessments of disease severity in dogs with chronic rhinitis and strong psychometric evidence was available to support the substantive, generalizability, content, and structural aspects of construct validity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
Widespread somatosensory sensitivity in naturally occurring canine model of osteoarthritis
PAIN, 157(6), 1325–1332.
Contributors: D. Knazovicky n , E. Helgeson n, B. Case n, M. Gruen n , W. Maixner n & B. Lascelles n
author keywords: Animal model; Osteoarthritis; Spontaneous osteoarthritis model; Quantitative sensory testing
MeSH headings : Animals; Arthralgia / physiopathology; Arthralgia / veterinary; Central Nervous System Sensitization / physiology; Dogs; Osteoarthritis / physiopathology; Osteoarthritis / veterinary; Pain Measurement; Pain Threshold / physiology; Physical Stimulation; Sensory Thresholds / physiology
TL;DR:
The canine spontaneous OA model is associated with somatosensory sensitivity, likely indicative of central sensitization in human patients' chronic pain, and is validated as an appropriate model of the human OA pain condition.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2016 journal article
ペット (イヌ, ネコ) の関節痛
Source: ORCID
Added: January 22, 2019
2015 journal article
A canine-specific anti-nerve growth factor antibody alleviates pain and improves mobility and function in dogs with degenerative joint disease-associated pain
BMC VETERINARY RESEARCH, 11(1).
Contributors: B. Lascelles n, D. Knazovicky n , B. Case n, M. Freire *, J. Innes, A. Drew*, D. Gearing*
author keywords: Nerve growth factor; Dog; Antibody; Pain; Model; Osteoarthritis; Accelerometry; Actimetry
MeSH headings : Animals; Antibodies / immunology; Antibodies / therapeutic use; Dog Diseases / therapy; Dogs; Double-Blind Method; Female; Immunotherapy / veterinary; Male; Nerve Growth Factor / immunology; Osteoarthritis / therapy; Osteoarthritis / veterinary; Pain / drug therapy; Pain / veterinary
TL;DR:
These pilot data demonstrate a positive analgesic effect of anti-NGF antibody in dogs suffering from chronic pain, similar to that expected with an NSAID.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
Analgesic efficacy of intraperitoneal administration of bupivacaine in cats
JOURNAL OF FELINE MEDICINE AND SURGERY, 18(11), 906–912.
MeSH headings : Analgesics, Opioid / administration & dosage; Anesthesia / veterinary; Anesthetics, Local / administration & dosage; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Buprenorphine / administration & dosage; Cats / physiology; Cats / surgery; Female; Hysterectomy / veterinary; Injections, Intraperitoneal / veterinary; Meloxicam; Ovariectomy / veterinary; Pain Measurement / veterinary; Pain, Postoperative / prevention & control; Pain, Postoperative / veterinary; Prospective Studies; Thiazines / administration & dosage; Thiazoles / administration & dosage; Treatment Outcome
TL;DR:
Based on rescue analgesia, IP administration of bupivacaine provides analgesia in cats after OVH and the DIVAS, MCPS and MNT were significantly different when compared with baseline values at different time points; however, data were not significantly different among groups.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
Assessment of an implant-skin interface scoring system for external skeletal fixation of dogs
American Journal of Veterinary Research, 76(11), 931–938.
MeSH headings : Animals; Dogs; External Fixators / veterinary; Fracture Fixation; Inflammation; Observer Variation; Orthopedics / methods; Orthopedics / standards; Photography; Reproducibility of Results; Skin / pathology; Veterinary Medicine / methods; Veterinary Medicine / standards
TL;DR:
An ISI scoring system used in this study had high repeatability and agreement and may therefore be considered for use in clinical situations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
Clinical safety of robenacoxib in feline osteoarthritis: results of a randomized, blinded, placebo-controlled clinical trial
JOURNAL OF FELINE MEDICINE AND SURGERY, 18(8), 632–642.
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / adverse effects; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Cat Diseases / drug therapy; Cats; Diphenylamine / adverse effects; Diphenylamine / analogs & derivatives; Diphenylamine / therapeutic use; Osteoarthritis / drug therapy; Osteoarthritis / veterinary; Phenylacetates / adverse effects; Phenylacetates / therapeutic use
TL;DR:
Robenacoxib was well tolerated when administered daily for 1 month in cats with osteoarthritis, including cats with evidence of concurrent CKD, and there was no clinical indication of damage to the gastrointestinal tract, kidney or liver.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
Criterion validation testing of clinical metrology instruments for measuring degenerative joint disease associated mobility impairment in cats
PLoS One, 10(7), e0131839.
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
2015 journal article
Defining the local nerve blocks for feline distal thoracic limb surgery: a cadaveric study
JOURNAL OF FELINE MEDICINE AND SURGERY, 18(10), 838–845.
MeSH headings : Animals; Cadaver; Cats / anatomy & histology; Female; Forelimb / innervation; Forelimb / surgery; Male; Median Nerve / anatomy & histology; Nerve Block / veterinary; Radial Nerve / anatomy & histology; Ulnar Nerve / anatomy & histology
TL;DR:
A four-point injection method based on cadaveric dissections and tested using dye injections may be an effective perioperative analgesia technique for feline distal thoracic limb procedures.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
Guidelines for recognition, assessment and treatment of pain
The Veterinary Nurse, 6(3), 164–173.
Source: ORCID
Added: January 22, 2019
2015 journal article
Initial evaluation of a canine stifle arthrotomy post-operative pain model
VETERINARY JOURNAL, 204(3), 293–298.
author keywords: Arthrotomy; Ground reaction force; Pain model; Percentage bodyweight distribution; Symmetry index; Extended-release buprenorphine
MeSH headings : Analgesics, Opioid / administration & dosage; Analgesics, Opioid / pharmacology; Animals; Buprenorphine / administration & dosage; Buprenorphine / pharmacology; Cross-Over Studies; Delayed-Action Preparations; Dogs; Male; Orthopedic Procedures / adverse effects; Orthopedic Procedures / veterinary; Pain Measurement / veterinary; Pain, Postoperative / drug therapy; Pain, Postoperative / pathology; Pain, Postoperative / veterinary; Stifle / surgery
TL;DR:
Subjective assessments did not detect the pain-inducing effects of arthrotomy or pain-alleviating effects of treatment, and subjective measures of procedural pain in research dogs need to be developed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
Initial evaluation of nighttime restlessness in a naturally occurring canine model of osteoarthritis pain
PeerJ, 3(2), e772.
Contributors: D. Knazovicky n , A. Tomas n, A. Motsinger-Reif n & B. Lascelles n
author keywords: Accelerometry; Dog; Pain; Model; Spontaneous; Accelerometry
TL;DR:
Although accelerometry does not appear to be useful, this model has potential to model the human pain-related nighttime sleep disturbance, and other outcome measures should be explored in this model.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2015 journal article
Prescription of perioperative analgesics by UK small animal veterinary surgeons in 2013
VETERINARY RECORD, 176(19).
author keywords: Analgesia; Cats; Dogs; Welfare
MeSH headings : Analgesia / veterinary; Analgesics / therapeutic use; Animals; Attitude of Health Personnel; Cats; Cross-Sectional Studies; Dogs; Drug Prescriptions / statistics & numerical data; Drug Prescriptions / veterinary; Female; Health Care Surveys; Humans; Male; Practice Patterns, Physicians' / statistics & numerical data; United Kingdom; Veterinarians / psychology; Veterinarians / statistics & numerical data
TL;DR:
A cross-sectional survey of UK practising small animal veterinary surgeons was undertaken in spring 2013, finding that analgesic prescription has increased since previous surveys, which should translate to improved animal welfare.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
the analgesic efficacy of intraperitoneal administration of bupivacaine in cats: 16.1.
Journal of Veterinary Pharmacology and Therapeutics, 38, 163.
Source: ORCID
Added: January 22, 2019
2014 journal article
Acute pain in cats: Treatment with NSAIDs
Today’s Veterinary Practice, May/June.
Source: NC State University Libraries
Added: January 25, 2019
2014 journal article
CLINICAL TRIALS INVOLVING CATS What factors affect owner participation?
JOURNAL OF FELINE MEDICINE AND SURGERY, 16(9), 727–735.
MeSH headings : Animals; Cat Diseases / therapy; Cats; Clinical Trials as Topic / veterinary; Pilot Projects; Research Design; Veterinarians / psychology
TL;DR:
The most influential factors were trust in the organization, benefit to the cat and veterinarian recommendation, which were not significantly different across groups, with ‘Free Services’ ranked highest.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2014 report
Challenges in evaluation of pain and a pre-incisional line block
PeerJ PrePrints.
Source: ORCID
Added: January 22, 2019
2014 personal communication
Chronic kidney disease in cats
Source: NC State University Libraries
Added: August 6, 2018
2014 journal article
Chronic kidney disease in cats.
Journal of the American Veterinary Medical Association, 244(7), 775.
Source: ORCID
Added: January 22, 2019
2014 journal article
Detection of Clinically Relevant Pain Relief in Cats with Degenerative Joint Disease Associated Pain
JOURNAL OF VETERINARY INTERNAL MEDICINE, 28(2), 346–350.
author keywords: Degenerative joint disease; Client-specific outcome measures; Osteoarthritis
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Cat Diseases / diagnosis; Cat Diseases / drug therapy; Cats; Double-Blind Method; Female; Male; Meloxicam; Osteoarthritis / complications; Osteoarthritis / diagnosis; Osteoarthritis / drug therapy; Osteoarthritis / veterinary; Pain Measurement / veterinary; Thiazines / therapeutic use; Thiazoles / therapeutic use
TL;DR:
Owners of cats with DJD were able to detect evident recurrence of clinical signs after withdrawal of active medication than after withdraw of placebo, and this study design might be a novel and useful way to circumvent the placebo effect and detect the efficacy of pain‐relieving medications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2014 journal article
Flexural properties of Ti6Al4V rhombic dodecahedron open cellular structures fabricated with electron beam melting
Additive Manufacturing, 1-4, 2–11.
Sources: Crossref, NC State University Libraries, ORCID
Added: January 22, 2019
2014 chapter
Gastroduodenal Ulceration
In Small Animal Soft Tissue Surgery (pp. 329–340). John Wiley & Sons, Ltd.
Source: ORCID
Added: January 30, 2019
2014 journal article
Guidelines for recognition, assessment and treatment of pain: WSAVA Global Pain Council members and co-authors of this document
Journal of Small Animal Practice, 55(6), E10–E68.
Source: ORCID
Added: January 22, 2019
2014 personal communication
J Vet Intern Med 2014; 28: 748
Source: NC State University Libraries
Added: August 6, 2018
2014 journal article
J Vet Intern Med 2014; 28: 748
JOURNAL OF VETERINARY INTERNAL MEDICINE, 28(3), 748–748.
Source: ORCID
Added: January 22, 2019
2014 journal article
Learning Confounds Algometric Assessment of Mechanical Thresholds in Normal Dogs
VETERINARY SURGERY, 43(3), 361–367.
MeSH headings : Animals; Biomechanical Phenomena; Dogs / physiology; Female; Learning; Male; Nociception / physiology; Pain / veterinary; Pressure / adverse effects
TL;DR:
Algometric pressure testing in normal dogs suggested that learning occurred over repeated collection time points, with dogs anticipating the stimulus and reacting at lower thresholds.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
4. Quality Education
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2014 journal article
Learning confounds algometric assessment of mechanical thresholds in normal dogs
Veterinary Surgery, 43(3), 361–367.
Source: ORCID
Added: January 22, 2019
2014 journal article
Letter to the Editor
Journal of Veterinary Internal Medicine, 28(3), 748–748.
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / adverse effects; Dog Diseases / chemically induced
TL;DR:
This study attempted to identify and evaluate the quality of information regarding NSAID-induced adverse effects in dogs through a systematic review, and suggested “Large clinical trials associated with better specific diagnostic tools may elucidate the incidence of renal adverse drug experience in dogs after NSAID administration”.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: January 22, 2019
2014 journal article
Mavacoxib and meloxicam for canine osteoarthritis: a randomised clinical comparator trial
VETERINARY RECORD, 175(11).
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Dog Diseases / drug therapy; Dogs; Female; Male; Meloxicam; Osteoarthritis / drug therapy; Osteoarthritis / veterinary; Pyrazoles / therapeutic use; Thiazines / therapeutic use; Thiazoles / therapeutic use; Treatment Outcome
TL;DR:
Clinical efficacy and adverse event rates are similar for meloxicam and mavacoxib when administered as per their UK SPC, which is relevant information for veterinary surgeons when prescribing NSAID treatment for canine OA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2014 journal article
Pathology of Articular Cartilage and Synovial Membrane From Elbow Joints With and Without Degenerative Joint Disease in Domestic Cats
VETERINARY PATHOLOGY, 51(5), 968–978.
author keywords: degenerative joint disease; elbow joint; feline; histopathology; medial compartment joint disease; synovial osteochondromatosis
MeSH headings : Animals; Bone and Bones / pathology; Cartilage, Articular / anatomy & histology; Cartilage, Articular / pathology; Cat Diseases / pathology; Cats; Female; Forelimb / anatomy & histology; Forelimb / pathology; Joint Diseases / pathology; Joint Diseases / veterinary; Joints / anatomy & histology; Joints / pathology; Male; Severity of Illness Index; Synovial Membrane / anatomy & histology; Synovial Membrane / pathology
TL;DR:
Lesions observed in these animals are most consistent with synovial osteochondromatosis secondary to degenerative joint disease, but a fragmented medial coronoid process or osteochondritis dissecans does not appear to play a role.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2014 journal article
Relationship Between Degenerative Joint Disease, Pain, and Bartonella spp. Seroreactivity in Domesticated Cats
Journal of Veterinary Internal Medicine, 29(1), 21–27.
MeSH headings : Animals; Antibodies, Bacterial / blood; Bartonella / isolation & purification; Bartonella Infections / immunology; Bartonella Infections / veterinary; Cat Diseases / blood; Cat Diseases / etiology; Cat Diseases / immunology; Cats; Female; Fluorescent Antibody Technique / veterinary; Male; Odds Ratio; Osteoarthritis / complications; Osteoarthritis / veterinary; Pain / etiology; Pain / veterinary; Risk Factors
TL;DR:
Bartonella spp.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2014 journal article
Relationship Between Mechanical Thresholds and Limb Use in Dogs With Coxofemoral Joint OA-Associated Pain and the Modulating Effects of Pain Alleviation From Total Hip Replacement on Mechanical Thresholds
VETERINARY SURGERY, 43(5), 542–548.
MeSH headings : Animals; Arthroplasty, Replacement, Hip / veterinary; Coccyx; Dog Diseases / physiopathology; Dog Diseases / surgery; Dogs; Female; Femur; Gait; Hip Joint / physiopathology; Joint Instability / physiopathology; Joint Instability / veterinary; Male; Pain Measurement / veterinary; Prospective Studies; Recovery of Function
TL;DR:
Successful unilateral THR results in decreased central sensitization after 12 months in dogs and there were no significant correlations between mQSTvF data and age, bodyweight or the GRF variables.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2014 journal article
Revision of a loose cementless short-stem threaded femoral component using a standard cementless stem in a canine hip arthroplasty
VETERINARY AND COMPARATIVE ORTHOPAEDICS AND TRAUMATOLOGY, 28(1), 54–59.
author keywords: Total hip replacement; revision; cementless stem
MeSH headings : Animals; Arthroplasty, Replacement, Hip / adverse effects; Arthroplasty, Replacement, Hip / instrumentation; Arthroplasty, Replacement, Hip / methods; Arthroplasty, Replacement, Hip / veterinary; Dog Diseases / diagnostic imaging; Dog Diseases / surgery; Dogs; Female; Hip Joint / diagnostic imaging; Hip Joint / surgery; Prosthesis Failure; Radiography; Reoperation / veterinary
TL;DR:
A Helica short-stemmed femoral prosthesis that was identified as being loose one year after implantation was revised with a standard long stem cementless BFX femoral pros-thesis, and the prosthetic components were stable.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2014 journal article
Systematic review of nonsteroidal anti-inflammatory drug-induced adverse effects in dogs (vol 27, pg 1011, 2013)
JOURNAL OF VETERINARY INTERNAL MEDICINE, 28(2), 745–745.
Source: ORCID
Added: January 22, 2019
2014 journal article
The Effect of Tramadol and Indomethacin Coadministration on Gastric Barrier Function in Dogs
Journal of Veterinary Internal Medicine, 28(3), 793–798.
Contributors: T. Hill *, B. Lascelles n, J. Law n & A. Blikslager n
author keywords: NSAID; tramadol; ulcer
MeSH headings : Analgesics, Opioid / administration & dosage; Analgesics, Opioid / pharmacology; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Cyclooxygenase 1 / metabolism; Cyclooxygenase 2 / metabolism; Dinoprostone / analysis; Dogs; Drug Therapy, Combination; Gastric Mucosa / chemistry; Gastric Mucosa / drug effects; Gastric Mucosa / physiology; Indomethacin / administration & dosage; Indomethacin / pharmacology; Thromboxane B2 / analysis; Tramadol / administration & dosage; Tramadol / pharmacology
TL;DR:
The results suggest that if there is an adverse interaction of the 2 drugs in vivo, it is unlikely to be via prostanoid inhibition, and could be via nonselective cyclooxygenase inhibition.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2014 journal article
The challenge of evaluating pain and a pre-incisional local anesthetic block
PEERJ, 2.
author keywords: Bupivacaine; Lidocaine; Pain assessment; Local anesthesia; Dog
TL;DR:
The outcome of this technique cannot be proven as there were no statistically significant differences between positive and negative controls, and the outcome could not be proven.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2014 journal article
characterisation Of Gene Expression In Naturally Occurring Feline Degenerative Joint Disease Associated Pain
Journal of Veterinary Internal Medicine, 28(4), 1358.
Source: ORCID
Added: January 22, 2019
2014 journal article
comparison of Thermal and Mechanical Quantitative Sensory Testing in Client-owned Dogs with Chronic Naturally Occurring Pain and Normal Dogs.
Veterinary Surgery, 43(6), E167.
Source: ORCID
Added: January 22, 2019
2014 journal article
efficacy Of Canine Anti-nerve Growth Factor Antibody For The Alleviation Of Degenerative Joint Disease-associated Pain In Dogs
Journal of Veterinary Internal Medicine, 28(4), 1367.
Source: ORCID
Added: January 22, 2019
2013 journal article
Assessment of cord dorsum potentials from caudal nerves in anesthetized clinically normal adult dogs without or during neuromuscular blockade
American Journal of Veterinary Research, 74(4), 616–620.
MeSH headings : Action Potentials / drug effects; Action Potentials / physiology; Anesthesia / veterinary; Animals; Dogs; Female; Male; Nerve Net / drug effects; Nerve Net / physiology; Neuromuscular Blockade / veterinary; Spinal Cord / drug effects; Spinal Cord / physiology
TL;DR:
This technique may be useful as a tool to assess the caudal nerve roots in dogs suspected of having compressive lumbosacral disease or myelopathies affecting the lumbar intumescence.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2013 journal article
Associations among exercise duration, lameness severity, and hip joint range of motion in Labrador Retrievers with hip dysplasia
Journal of the American Veterinary Medical Association, 242(11), 1528–1533.
Source: ORCID
Added: January 22, 2019
2013 journal article
Attitude of B razilian veterinarians in the recognition and treatment of pain in horses and cattle
Veterinary Anaesthesia and Analgesia, 40(4), 410–418.
Source: ORCID
Added: January 22, 2019
2013 journal article
Attitude of Brazilian veterinarians in the recognition and treatment of pain in horses and cattle
VETERINARY ANAESTHESIA AND ANALGESIA, 40(4), 410–418.
author keywords: analgesia; analgesics; attitudes; NSAIDs; opioids
MeSH headings : Adult; Analgesics / therapeutic use; Animal Welfare; Animals; Brazil; Cattle; Cattle Diseases / drug therapy; Data Collection; Female; Health Knowledge, Attitudes, Practice; Horse Diseases / drug therapy; Horses; Humans; Knowledge; Male; Pain / drug therapy; Pain / veterinary; Surveys and Questionnaires; Veterinarians / standards
TL;DR:
Assessment of the use of analgesics, attitudes of Brazilian veterinarians towards pain relief in horses and cattle and the differences due to gender, year of graduation and type of practice found that analgesic in large animals was similar in Brazil to that reported in other countries.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2013 journal article
Biomechanical Evaluation of the Influence of an Intramedullary Pin on the Stability of a Feline Ilial Fracture Model Stabilized With a Bone Plate
VETERINARY SURGERY, 43(2), 114–119.
MeSH headings : Animals; Biomechanical Phenomena; Bone Plates; Cadaver; Cats / surgery; Fracture Fixation, Internal / instrumentation; Fracture Fixation, Internal / methods; Fracture Fixation, Internal / veterinary; Fractures, Bone / surgery; Fractures, Bone / veterinary; Ilium / pathology; Ilium / surgery
TL;DR:
The P + P constructs were not significantly stronger than plates alone in this acutely loaded cadaveric model and no biomechanical advantage was demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2013 conference paper
Comparison of activity of normal and degenerative joint disease-affected cats
(2013, February 20). Presented at the NCSU College of Veterinary Medicine Annual Research Forum, Raleigh, NC.
Event: NCSU College of Veterinary Medicine Annual Research Forum at Raleigh, NC
Source: NC State University Libraries
Added: February 12, 2021
2013 journal article
Comparison of the effect of intratesticular lidocaine/bupivacaine vs. saline placebo on pain scores and incision site reactions in dogs undergoing routine castration
The Veterinary Journal, 196(3), 499–503.
author keywords: Anesthesia; Bupivacaine; Canine; Castration; Lidocaine
MeSH headings : Anesthetics, Local / administration & dosage; Anesthetics, Local / pharmacology; Animals; Bupivacaine / administration & dosage; Bupivacaine / pharmacology; Dogs; Drug Administration Routes; Drug Therapy, Combination; Lidocaine / administration & dosage; Lidocaine / pharmacology; Male; Orchiectomy / adverse effects; Pain / prevention & control; Pain / veterinary; Pain Measurement / veterinary
TL;DR:
Post-operative pain scores and incision site reactions were compared in healthy dogs undergoing routine castration at a county animal shelter and assigned to two treatment groups, namely: lidocaine/bupivacaine or placebo, via intratesticular injection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2013 journal article
Current attitudes regarding the use of perioperative analgesics in dogs and cats by Brazilian veterinarians
VETERINARY ANAESTHESIA AND ANALGESIA, 41(1), 82–89.
author keywords: analgesia; analgesics; attitudes; NSAIDs; opioids
MeSH headings : Analgesics / administration & dosage; Animal Welfare; Animals; Brazil; Cat Diseases / drug therapy; Cats; Data Collection; Dog Diseases / drug therapy; Dogs; Female; Health Knowledge, Attitudes, Practice; Humans; Male; Pain, Postoperative / prevention & control; Pain, Postoperative / veterinary; Perioperative Care / veterinary; Surveys and Questionnaires; Veterinarians
TL;DR:
Although the number of Brazilian veterinarians believed that their knowledge in the area was lower than in other countries, the focus in pain management was similar or higher than inother countries, showing a good attitude in pain relief in animals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2013 conference paper
Development of a questionnaire to assess chronic pain associated with feline degenerative joint disease
AVA Scientific Spring Meeting, 40(1), 19. Davos, Switzerland.
Event: AVA Scientific Spring Meeting at Davos, Switzerland
Source: NC State University Libraries
Added: February 12, 2021
2013 journal article
Evaluation of Construct and Criterion Validity for the 'Liverpool Osteoarthritis in Dogs' (LOAD) Clinical Metrology Instrument and Comparison to Two Other Instruments
PLOS ONE, 8(3).
MeSH headings : Animals; Dog Diseases / diagnosis; Dogs; Factor Analysis, Statistical; Female; Male; Osteoarthritis / veterinary; Pain / veterinary; Pain Measurement; Prospective Studies
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2013 journal article
Evaluation of construct and criterion validity for the ‘Liverpool Osteoarthritis in Dogs’(LOAD) clinical metrology instrument and comparison to two other instruments
PLoS One, 8(3), e58125.
Source: ORCID
Added: January 22, 2019
2013 conference paper
Evaluation of meloxicam and tepoxalin in cats
Veterinary Anaesthesia and Analgesia, 40(1), 21.
Event: Association of Veterinary Anaesthetists Spring Meeting at Davos, Switzerland on March 22-23, 2012
Source: NC State University Libraries
Added: March 9, 2021
2013 journal article
Evaluation of the clinical use of tepoxalin and meloxicam in cats
JOURNAL OF FELINE MEDICINE AND SURGERY, 15(8), 678–690.
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Cat Diseases / drug therapy; Cats; Female; Male; Meloxicam; Pyrazoles / adverse effects; Pyrazoles / therapeutic use; Retrospective Studies; Thiazines / adverse effects; Thiazines / therapeutic use; Thiazoles / adverse effects; Thiazoles / therapeutic use
TL;DR:
Tepoxalin and meloxicam are well tolerated in the clinical setting at the doses prescribed in this study, and several statistically significant changes for serum biochemistry and hematology parameters were within normal limits.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2013 journal article
Ex vivo effect of gold nanoparticles on porcine synovial membrane
Tissue Barriers, 1(2), e24314.
Source: ORCID
Added: January 22, 2019
2013 chapter
Eyelids, Eye, and Orbit
In Veterinary Surgical Oncology (pp. 383–404). John Wiley & Sons, Ltd,.
Source: ORCID
Added: January 30, 2019
2013 conference paper
Feasibility and Repeatability of Cold and Mechanical Quantitative Sensory Testing in Dogs as a measure of neuropthic pain states
Presented at the NCSU College of Veterinary Medicine Annual Research Forum, Raleigh, NC.
Event: NCSU College of Veterinary Medicine Annual Research Forum at Raleigh, NC
Source: NC State University Libraries
Added: February 12, 2021
2013 journal article
Feasibility and repeatability of cold and mechanical quantitative sensory testing in normal dogs
VETERINARY JOURNAL, 199(2), 245–250.
author keywords: Canine; Quantitative sensory testing; Pressure algometer; Electronic von Frey anesthesiometer
MeSH headings : Animals; Cold Temperature; Dogs / physiology; Electrical Equipment and Supplies / veterinary; Feasibility Studies; Female; Male; Mechanoreceptors / physiology; Pain Measurement / methods; Reproducibility of Results; Sensation / physiology; Sensory Thresholds / physiology
TL;DR:
Both mechanical QST devices tested provided repeatable, reliable sensory threshold measurements in normal, client-owned dogs and contribute to the validation of the EVF and PA as tools to obtain repeated QST data over time in dogs to assess somatosensory processing changes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2013 journal article
Feasibility and repeatability of thermal quantitative sensory testing in normal dogs and dogs with hind limb osteoarthritis-associated pain
VETERINARY JOURNAL, 199(1), 63–67.
author keywords: Canine; Quantitative sensory testing; Osteoarthritis; Thermal threshold
MeSH headings : Animals; Differential Threshold / physiology; Dog Diseases / diagnosis; Dog Diseases / pathology; Dogs; Hindlimb / pathology; Hot Temperature / adverse effects; Neurologic Examination; Osteoarthritis / diagnosis; Osteoarthritis / pathology; Osteoarthritis / veterinary; Pain / diagnosis; Pain / pathology; Pain / veterinary; Pain Threshold
TL;DR:
In conclusion, thermal thresholds can be measured in client owned dogs with no prior training and are repeatable from week to week.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2013 journal article
Feline Musculoskeletal Pain Index: Responsiveness and Testing of Criterion Validity
JOURNAL OF VETERINARY INTERNAL MEDICINE, 27(3), 474–482.
author keywords: DJD; Chronic pain; Feline; FMPI; Meloxicam
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Cat Diseases / diagnosis; Cat Diseases / drug therapy; Cats; Female; Male; Meloxicam; Musculoskeletal Pain / diagnosis; Musculoskeletal Pain / drug therapy; Musculoskeletal Pain / veterinary; Surveys and Questionnaires; Thiazines / therapeutic use; Thiazoles / therapeutic use
TL;DR:
The data suggest that further work is indicated to understand factors affecting activity in cats to optimize inclusion criteria, and neither responsiveness nor criterion validity were detected by the inclusion criteria for cases in this study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2013 journal article
Feline degenerative joint disease: a genomic and proteomic approach
JOURNAL OF FELINE MEDICINE AND SURGERY, 15(6), 466–477.
MeSH headings : Animals; Cat Diseases / genetics; Cat Diseases / metabolism; Cat Diseases / pathology; Cats; Gene Expression Regulation; Genetic Predisposition to Disease; Genomics; Osteoarthritis / genetics; Osteoarthritis / metabolism; Osteoarthritis / veterinary; Proteomics
TL;DR:
A custom-designed feline GeneChip was employed and the institution’s unique access to large sample populations to investigate genes and proteins from whole blood and serum that may be up- or down-regulated in DJD cats to better understand disease pathogenesis and diagnose it more easily, and to better target it with pharmaceutical and nutritional intervention.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2013 article
Getting a sense of sensations
Lascelles, B. D. X. (2013, August). VETERINARY JOURNAL, Vol. 197, pp. 115–117.
MeSH headings : Animals; Dog Diseases / pathology; Electric Stimulation / adverse effects; Neurologic Examination / veterinary; Sensory Thresholds / physiology; Spinal Cord Injuries / veterinary
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2013 journal article
Histological and molecular characterisation of feline humeral condylar osteoarthritis
BMC VETERINARY RESEARCH, 9.
author keywords: Osteoarthritis; Feline; Humeral condyle; Gene expression; Histomorphometry
MeSH headings : Animals; Cartilage, Articular / metabolism; Cartilage, Articular / pathology; Cat Diseases / metabolism; Cat Diseases / pathology; Cats; Chondrocytes / metabolism; Chondrocytes / pathology; Female; Humerus / metabolism; Humerus / pathology; Male; Osteoarthritis / metabolism; Osteoarthritis / pathology; Osteoarthritis / veterinary; Osteocytes / pathology; Real-Time Polymerase Chain Reaction / veterinary; Transcriptome
TL;DR:
Histopathological changes identified in OA of the feline humeral condyle appear to primarily affect the medial aspect of the joint, and suggest that SCB is involved in the OA process in cats.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2013 chapter
Oral Tumors
In Veterinary Surgical Oncology (pp. 119–177). John Wiley & Sons, Ltd,.
Source: ORCID
Added: January 30, 2019
2013 conference paper
Owner-assessed indices of quality of life in cats and the relationship to the presence of chronic pain-DJD
Veterinary Anaesthesia and Analgesia, 40(1), 21–22.
Event: Association of Veterinary Anaesthetists Spring Meeting at Davos, Switzerland on February 22-23, 2012
Source: NC State University Libraries
Added: March 9, 2021
2013 journal article
Prevalence and classification of chronic kidney disease in cats randomly selected from four age groups and in cats recruited for degenerative joint disease studies
JOURNAL OF FELINE MEDICINE AND SURGERY, 16(6), 465–472.
MeSH headings : Age Factors; Animals; Cat Diseases / classification; Cat Diseases / diagnosis; Cat Diseases / epidemiology; Cats; Osteoarthritis / classification; Osteoarthritis / epidemiology; Osteoarthritis / veterinary; Prevalence; Renal Insufficiency, Chronic / classification; Renal Insufficiency, Chronic / epidemiology; Renal Insufficiency, Chronic / veterinary; Retrospective Studies; Risk Factors
TL;DR:
Significant concurrence between CKD and DJD in cats of all ages is found, indicating the need for increased screening for CKD when selecting DJD treatments and the idea of a relationship and causal commonality between CKd andDJD owing to the striking concurrence across age groups and life stages.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2013 journal article
Reliability and discriminatory testing of a client-based metrology instrument, feline musculoskeletal pain index (FMPI) for the evaluation of degenerative joint disease-associated pain in cats
The Veterinary Journal, 196(3), 368–373.
author keywords: Assessment; Degenerative joint disease; Feline; Pain
MeSH headings : Animals; Cat Diseases / diagnosis; Cat Diseases / pathology; Cats; Osteoarthritis / pathology; Osteoarthritis / veterinary; Pain / diagnosis; Pain / pathology; Pain / veterinary; Pain Measurement / methods; Pain Measurement / veterinary
TL;DR:
An initial evaluation of the FMPI suggests that this instrument is worthy of continued investigation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: January 22, 2019
2013 journal article
Survey on analgesia in small animals
Veterinary Record, 172(17), 457.2–457.
MeSH headings : Analgesia / statistics & numerical data; Analgesia / veterinary; Animals; Pets; United Kingdom; Veterinary Medicine / methods; Veterinary Medicine / statistics & numerical data
TL;DR:
Over the past 18 years there has been a big investment in small animal analgesia research, undergraduate teaching and CPD in this field, and the number of licensed analgesic drugs available for use in cats and dogs has increased.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: August 6, 2018
2013 article
Survey on analgesia in small animals
Source: ORCID
Added: January 30, 2019
2013 review
Systematic Review of Nonsteroidal Anti-Inflammatory Drug-Induced Adverse Effects in Dogs
[Review of ]. JOURNAL OF VETERINARY INTERNAL MEDICINE, 27(5), 1011–1019.
author keywords: Osteoarthritis; Pain; Evidence-based medicine; Analgesia; Canine
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / adverse effects; Dog Diseases / chemically induced; Dogs
TL;DR:
The aim of this systematic review was to identify, assess, and critically evaluate the quality of evidence of nonsteroidal anti-inflammatory drug (NSAID)-induced adverse effects in dogs, and most studies were not appropriately designed to determine the safety of NSAIDs, and involved a healthy nongeriatric population of research dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2013 journal article
Systematic review of nonsteroidal anti-inflammatory drug-induced adverse effects in dogs
Journal of Veterinary Internal Medicine, 27(5), 1011–1019.
Source: ORCID
Added: January 22, 2019
2013 journal article
Variability of performance of wound infusion catheters
Veterinary Anaesthesia and Analgesia, 40(3), 308–315.
author keywords: analgesia; infusion catheter; local anesthetic; pain; postoperative analgesia; wound infusion
MeSH headings : Anesthetics, Local / administration & dosage; Animals; Catheterization / instrumentation; Catheterization / veterinary; Drug Delivery Systems; Infusions, Parenteral; Microscopy, Electron, Scanning; Pain Management; Pain, Postoperative; Wounds and Injuries
TL;DR:
Constant-rate infusions of 3 mL hour(-1) provide erratic distribution of flow from wound infusion catheters in a bench top apparatus, which may contribute to inconsistent or unsatisfactory pain relief in patients treated with continuous wound infusion of local anesthetics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: ORCID, NC State University Libraries, Crossref, NC State University Libraries
Added: August 6, 2018
2013 journal article
stifle Arthrotomy: A New Model of Surgical Pain in the Dog.
Veterinary Surgery, 42(7), E110.
Source: ORCID
Added: January 22, 2019
2012 journal article
Comparison of Body Weight Distribution, Peak Vertical Force, and Vertical Impulse as Measures of Hip Joint Pain and Efficacy of Total Hip Replacement
VETERINARY SURGERY, 41(4), 443–447.
MeSH headings : Animals; Arthroplasty, Replacement, Hip / standards; Arthroplasty, Replacement, Hip / veterinary; Biomechanical Phenomena; Body Weight; Dogs; Female; Hip Dysplasia, Canine / physiopathology; Hip Dysplasia, Canine / surgery; Hip Joint / pathology; Hip Joint / physiopathology; Hip Prosthesis / standards; Hip Prosthesis / veterinary; Male; Movement; Pain / veterinary; Pain Measurement / veterinary; Posture; Prospective Studies; Treatment Outcome
TL;DR:
There appeared to be no difference in the sensitivity of VI, PVF, and %BW(dist) for evaluating limb use before and after total hip replacement (THR) surgery.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2012 conference paper
Comparison of GRF measures for hip pain
ACVS Scientific Symposium. Presentation accepted.
Source: NC State University Libraries
Added: March 5, 2021
2012 journal article
EVALUATION OF CYCLOOXYGENASE PROTEIN EXPRESSION IN TRAUMATIZED VERSUS NORMAL TISSUES FROM EASTERN BOX TURTLES (TERRAPENE CAROLINA CAROLINA)
Journal of Zoo and Wildlife Medicine, 43(2), 289–295.
author keywords: Chelonian; eastern box turtle; Terrapene carolina; cyclooxygenase-1; cyclooxygenase-2; nonsteroidal anti-inflammatory drug
MeSH headings : Animals; Cyclooxygenase 1 / genetics; Cyclooxygenase 1 / metabolism; Cyclooxygenase 2 / genetics; Cyclooxygenase 2 / metabolism; Gene Expression Regulation, Enzymologic / physiology; Muscle, Skeletal / enzymology; Turtles; Wounds and Injuries / metabolism; Wounds and Injuries / veterinary
TL;DR:
Traditional nonsteroidal anti-inflammatory drugs that block both COX isoforms might be more efficacious than COX-2–selective drugs, and NSAIDs should be evaluated for potential liver and kidney toxicity in turtles.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Crossref, NC State University Libraries
Added: January 22, 2019
2012 article
Eyelids, Eye, and Orbit
Lascelles, B. D. X., & Davidson, M. (2013, April 3). Veterinary Surgical Oncology, pp. 383–404.
Source: ORCID
Added: January 22, 2019
2012 conference paper
Functional outcomes in a hip arthritis model
ACVS Scientific Symposium. Presentation accepted.
Source: NC State University Libraries
Added: March 5, 2021
2012 article
Gastroduodenal Ulceration
Hill, T. L., Lascelles, B. D. X., & Blikslager, A. (2014, July). Small Animal Soft Tissue Surgery, pp. 329–340.
Contributors: T. Hill, B. Lascelles & A. Blikslager*
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: ORCID
Added: January 22, 2019
2012 chapter
Management of Chronic Cancer Pain
In S. Withrow, V. D, & R. Page (Eds.), Small Animal Clinical Oncology (5th ed., pp. 245–259). St. Louis, Missouri, USA: Saunders Elsevier.
Ed(s): S. Withrow, V. D & R. Page
Source: NC State University Libraries
Added: January 25, 2019
2012 conference paper
Management of long bone tumors with custom freeform total joint prostheses
Tuohy, J., Kwan, T., Horn, T., Harrysson, O. L. A., Lascelles, B. D. X., & Marcellin-Little, D. J. (2012, May 24). Presented at the 1st Scientific Meeting of the Veterinary Society of Surgical Oncology, Fort Collins, CO.
Event: 1st Scientific Meeting of the Veterinary Society of Surgical Oncology at Fort Collins, CO on May 24-25, 2012
Source: NC State University Libraries
Added: March 9, 2021
2012 article
Oral Tumors
Liptak, J. M., & Lascelles, B. D. X. (2013, April 3). Veterinary Surgical Oncology, pp. 119–177.
Source: ORCID
Added: January 22, 2019
2012 conference paper
Outcome measures and neurobiological insights in a naturally occurring canine model of OA
Lascelles, B. D., Marcellin-Little, D. J., Roe, S. C., & Hansen, B. D. (2012, March 20). Presented at the North Carolina Cartilage-Arthritis Research Alliance (NC-CARA) Meeting, Chapel Hill, NC.
Event: North Carolina Cartilage-Arthritis Research Alliance (NC-CARA) Meeting at Chapel Hill, NC
Source: NC State University Libraries
Added: March 5, 2021
2012 conference paper
Owner questionnaire to assess feline DJD pain
ACVS Scientific Symposium. Presentation accepted.
Source: NC State University Libraries
Added: March 5, 2021
2012 journal article
Owner-assessed indices of quality of life in cats and the relationship to the presence of degenerative joint disease
JOURNAL OF FELINE MEDICINE AND SURGERY, 14(12), 863–870.
MeSH headings : Animals; Cat Diseases / prevention & control; Cat Diseases / psychology; Cats; Female; Human-Animal Bond; Humans; Joint Diseases / psychology; Joint Diseases / veterinary; Joint Instability / psychology; Joint Instability / veterinary; Male; Quality of Life; Running; Surveys and Questionnaires; Walking
TL;DR:
Regardless of DJD status, 40% of items listed by owners involved mobility, while 60% were ‘inactive’ items, rejecting the hypothesis that items contributing to QoL in cats are predominantly items requiring mobility.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2012 article
Radiographic evaluation of early periprosthetic femoral bone contrast and prosthetic stem alignment after uncemented and cemented total hip replacement in dogs
Source: ORCID
Added: January 30, 2019
2012 journal article
Relationship of orthopedic examination, goniometric measurements, and radiographic signs of degenerative joint disease in cats
BMC VETERINARY RESEARCH, 8(1).
author keywords: Pain; Degenerative joint disease; Osteoarthritis; Feline; Goniometry; Orthopedic; Joint
MeSH headings : Age Distribution; Animals; Arthrometry, Articular / veterinary; Cat Diseases / diagnosis; Cat Diseases / diagnostic imaging; Cat Diseases / pathology; Cats; Osteoarthritis / diagnosis; Osteoarthritis / diagnostic imaging; Osteoarthritis / pathology; Osteoarthritis / veterinary; Pain / etiology; Pain / veterinary; Predictive Value of Tests; Radiography; Sensitivity and Specificity
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2012 conference paper
Repeatability and comparison of thermal threshold latency measures in normal dogs and dogs with pelvic limb osteoarthritis
Williams, M. D., Kirkpatrick, A. E., Benito, J., Hash, J., Thomson, A., & Lascelles, B. D. X. (2012, August 26). Presented at the International Association for the Study of Pain, Non-Human Species Special Interest Group Satellite Meeting.
Event: International Association for the Study of Pain, Non-Human Species Special Interest Group Satellite Meeting on August 26, 2012
Source: NC State University Libraries
Added: March 5, 2021
2012 journal article
Safety evaluation of a natural eggshell membrane-derived product
Food and Chemical Toxicology, 50(3-4), 604–611.
Source: ORCID
Added: January 22, 2019
2012 journal article
Su1738 Misoprostol Protects Gastric Barrier Function After Acid Injury in an Ex Vivo Canine Model
Gastroenterology, 142(5), S-492.
Sources: ORCID, Crossref, NC State University Libraries
Added: January 22, 2019
2012 chapter
Surgical Pain: Pathophysiology, Assessment, and Treatment Strategies
In K. M. Tobias & S. A. Johnston (Eds.), Veterinary Surgery Small Animal (pp. 237–247). St Louis, MO, USA: Elsevier Saunders.
Ed(s): K. Tobias & S. Johnston
Source: NC State University Libraries
Added: January 25, 2019
2011 book
BSAVA manual of canine and feline oncology
Gloucester: British Small Animal Veterinary Association.
Source: NC State University Libraries
Added: August 6, 2018
2011 book
BSAVA manual of canine and feline oncology.
British Small Animal Veterinary Association.
Source: ORCID
Added: January 22, 2019
2011 book
British Small Animal Veterinary Association Manual of Oncology
(Vol. 3). Gloucester, UK: British Small Animal Veterinary Association.
Source: NC State University Libraries
Added: January 25, 2019
2011 journal article
Dose reduction of meloxicam in dogs with osteoarthritis-associated pain and impaired mobility
J Vet Intern Med, 25(6), 1298–1305.
author keywords: Arthritis; Chronic; Nonsteroidal anti-inflammatory drug
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Dog Diseases / drug therapy; Dogs; Dose-Response Relationship, Drug; Female; Male; Meloxicam; Osteoarthritis / complications; Osteoarthritis / drug therapy; Osteoarthritis / veterinary; Pain / drug therapy; Pain / etiology; Pain / veterinary; Thiazines / administration & dosage; Thiazines / therapeutic use; Thiazoles / administration & dosage; Thiazoles / therapeutic use; Time Factors
TL;DR:
Dose reduction is a less effective means of pain control compared with maintained dosing, however, NSAID dose reduction with maintained efficacy is possible, but success appears to be individual dog dependent.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 25, 2019
2011 journal article
Pain physiology, pharmacology and management
Essentials of Small Animal Anesthesia and Analgesia. 2nd Ed. Chinchester, West Sussex, England: John Wiley & Sons, 82–146.
Source: ORCID
Added: January 22, 2019
2011 journal article
RADIOGRAPHIC EVALUATION OF FELINE APPENDICULAR DEGENERATIVE JOINT DISEASE VS. MACROSCOPIC APPEARANCE OF ARTICULAR CARTILAGE
VETERINARY RADIOLOGY & ULTRASOUND, 52(3), 239–247.
author keywords: cartilage damage; cat; DJD; macroscopic; radiographs
MeSH headings : Animals; Arthrography / veterinary; Cartilage, Articular / diagnostic imaging; Cartilage, Articular / pathology; Cat Diseases / diagnostic imaging; Cat Diseases / pathology; Cats; Female; Joint Diseases / diagnostic imaging; Joint Diseases / pathology; Joint Diseases / veterinary; Joints / pathology; Male; Radiographic Image Enhancement
TL;DR:
The data support radiographic findings not relating well to cartilage degeneration, and that other modalities should be evaluated to aid in making a diagnosis of feline DJD.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2011 journal article
Radiographic Evaluation of Early Periprosthetic Femoral Bone Contrast and Prosthetic Stem Alignment after Uncemented and Cemented Total Hip Replacement in Dogs
VETERINARY SURGERY, 41(1), 69–77.
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
"Post-operative analgesia in the dog: A comparison of morphine, buprenorphine and pentazocine"
Journal of Small Animal Practice, 51, 46–47.
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
Cross-Sectional Study of the Prevalence of Radiographic Degenerative Joint Disease in Domesticated Cats
Veterinary Surgery, 39(5), 535–544.
MeSH headings : Age Factors; Animals; Cat Diseases / diagnostic imaging; Cat Diseases / epidemiology; Cats; Cross-Sectional Studies; Female; Joint Diseases / diagnostic imaging; Joint Diseases / epidemiology; Joint Diseases / veterinary; Male; Poisson Distribution; Prevalence; Prospective Studies; Radiography
TL;DR:
Radiographically visible DJD is very common in domesticated cats, even in young animals and is strongly associated with age, which requires further investigation of its associated clinical signs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2010 journal article
Cross-sectional study of the prevalence of radiographic degenerative joint disease in domesticated cats
Veterinary Surgery, 39(5), 535–544.
Source: ORCID
Added: January 22, 2019
2010 review
DJD-ASSOCIATED PAIN IN CATS What can we do to promote patient comfort?
[Review of ]. JOURNAL OF FELINE MEDICINE AND SURGERY, 12(3), 200–212.
MeSH headings : Age Factors; Animals; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Cat Diseases / drug therapy; Cat Diseases / epidemiology; Cat Diseases / prevention & control; Cats; Evidence-Based Medicine; Joint Diseases / drug therapy; Joint Diseases / epidemiology; Joint Diseases / veterinary; Joint Instability / veterinary; Neurologic Examination / veterinary; Osteoarthritis / drug therapy; Osteoarthritis / epidemiology; Osteoarthritis / veterinary; Pain Measurement / veterinary; Prevalence; Risk Factors; Severity of Illness Index; Veterinary Medicine
TL;DR:
Degenerative joint disease (DJD) has a high prevalence in domestic cats and can be associated with pain, and there is a lack of information on the etiology of feline DJD and a relative lack of data on the efficacy of putative treatments.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
DJD-associated pain in cats: what can we do to promote patient comfort?
Journal of Feline Medicine and Surgery, 12(3), 200–212.
Source: ORCID
Added: January 22, 2019
2010 journal article
Elbow denervation in dogs: Development of an in vivo surgical procedure and pilot testing
VETERINARY JOURNAL, 190(2), 220–224.
author keywords: Dog; Elbow; Degenerative joint disease; Pain; Denervation
MeSH headings : Animals; Denervation / adverse effects; Denervation / methods; Denervation / veterinary; Dog Diseases / surgery; Dogs; Elbow Joint / innervation; Elbow Joint / physiology; Elbow Joint / surgery; Feasibility Studies; Female; Forelimb / physiology; Joint Diseases / surgery; Joint Diseases / veterinary; Lameness, Animal / etiology; Male; Pain Measurement / veterinary; Pain, Postoperative / veterinary; Pilot Projects; Touch / physiology
TL;DR:
The protocol developed for denervation of the canine elbow appears feasible and does not result in any sensory or motor deficits of the forelimb.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
Evaluation of Functional Outcome After BFX (R) Total Hip Replacement Using a Pressure Sensitive Walkway
VETERINARY SURGERY, 39(1), 71–77.
MeSH headings : Animals; Arthroplasty, Replacement, Hip / veterinary; Biomechanical Phenomena / physiology; Dog Diseases / diagnostic imaging; Dog Diseases / physiopathology; Dog Diseases / surgery; Dogs; Female; Hip Prosthesis / veterinary; Male; Osteoarthritis, Hip / diagnostic imaging; Osteoarthritis, Hip / physiopathology; Osteoarthritis, Hip / surgery; Osteoarthritis, Hip / veterinary; Postural Balance / physiology; Prospective Studies; Radiography; Treatment Outcome; Weight-Bearing / physiology
TL;DR:
BFX THR normalizes standing bodyweight distribution dogs with hip osteoarthritis and results in normal %BW(distrib) to the operated limb by 3 months after surgery.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
Evaluation of a Midhumeral Block of the Radial, Ulnar, Musculocutaneous and Median (RUMM Block) Nerves for Analgesia of the Distal Aspect of the Thoracic Limb in Dogs
Veterinary Surgery, 39(7), 785–796.
MeSH headings : Anesthetics, Local / administration & dosage; Anesthetics, Local / therapeutic use; Animals; Brachial Plexus / drug effects; Bupivacaine / administration & dosage; Bupivacaine / therapeutic use; Dogs; Forelimb / innervation; Forelimb / surgery; Humerus; Median Nerve / drug effects; Musculocutaneous Nerve / drug effects; Nerve Block / methods; Nerve Block / veterinary; Radial Nerve / drug effects; Ulnar Nerve / drug effects
TL;DR:
Sensory thresholds were significantly increased over baseline measurements when compared with control limbs for all nerves, and RUMM block may be an effective technique to provide adjunctive analgesia for dogs undergoing surgery of the distal aspect of the thoracic limb.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2010 journal article
Evaluation of a Therapeutic Diet for Feline Degenerative Joint Disease
JOURNAL OF VETERINARY INTERNAL MEDICINE, 24(3), 487–495.
author keywords: Arthritis; Cat; Mobility; Nutrition
MeSH headings : Animal Feed / analysis; Animal Nutritional Physiological Phenomena; Animals; Cat Diseases / diet therapy; Cats; Diet / veterinary; Docosahexaenoic Acids / chemistry; Docosahexaenoic Acids / pharmacology; Eicosapentaenoic Acid / chemistry; Eicosapentaenoic Acid / pharmacology; Osteoarthritis / diet therapy; Osteoarthritis / veterinary
TL;DR:
A diet high in EPA and DHA and supplemented with green-lipped mussel extract and glucosamine/chondroitin sulfate improved objective measures of mobility.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
Evaluation of intermittent infusion of bupivacaine into surgical wounds of dogs postoperatively
VETERINARY JOURNAL, 190(2), 287–289.
author keywords: Bupivacaine; Local anesthesia; Wound infusion; Dog; Analgesia; Post-operative pain
MeSH headings : Anesthetics, Local / pharmacokinetics; Anesthetics, Local / therapeutic use; Animals; Bupivacaine / pharmacokinetics; Bupivacaine / therapeutic use; Dogs / surgery; Double-Blind Method; Infusions, Intralesional / veterinary; Pain Measurement / veterinary; Pain, Postoperative / drug therapy; Pain, Postoperative / veterinary; Postoperative Care / veterinary; Prospective Studies; Recovery of Function; Wound Healing
TL;DR:
Bupivacaine infusion into surgical wounds after surgery may improve post-operative recovery, but no effect on wound tenderness was demonstrated in this study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
Evaluation of the relationship between lesions in the gastroduodenal region and cyclooxygenase expression in clinically normal dogs
American Journal of Veterinary Research, 71(6), 630–635.
Contributors: J. Wooten n, B. Lascelles n, V. Cook*, J. Law n & A. Blikslager n
MeSH headings : Animals; Blotting, Western / veterinary; Cyclooxygenase 1 / biosynthesis; Cyclooxygenase 2 / biosynthesis; Dog Diseases / enzymology; Dog Diseases / pathology; Dogs / metabolism; Duodenitis / enzymology; Duodenitis / pathology; Duodenitis / veterinary; Duodenum / enzymology; Duodenum / pathology; Female; Gastritis / enzymology; Gastritis / pathology; Gastritis / veterinary; Immunohistochemistry / veterinary; Intestinal Mucosa / enzymology; Intestinal Mucosa / pathology; Male; Pylorus / enzymology; Pylorus / pathology; Statistics, Nonparametric
TL;DR:
Dogs that appear to be clinically normal may have underlying gastroduodenal lesions associated with upregulation of COX-2, and practitioners should be aware of this potential situation when prescribing COX inhibitors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2010 review
Feline Degenerative Joint Disease
[Review of ]. VETERINARY SURGERY, 39(1), 2–13.
MeSH headings : Animals; Cat Diseases / diagnostic imaging; Cat Diseases / epidemiology; Cat Diseases / therapy; Cats; Hip Joint / diagnostic imaging; Joint Diseases / diagnostic imaging; Joint Diseases / epidemiology; Joint Diseases / therapy; Joint Diseases / veterinary; Osteoarthritis / diagnostic imaging; Osteoarthritis / veterinary; Pain / veterinary; Pain Measurement / veterinary; Prevalence; Radiography; Spine / diagnostic imaging; Stifle / diagnostic imaging
TL;DR:
The high prevalence of feline DJD and lack of information about it, suggests further investigation is needed, and development of a feline model of chronic DJD-associated pain may speed the development and evaluation of candidate pain-alleviating compounds and treatments.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
Feline osteoarthritis
Vet Surg, 39(1), 2–13.
Source: ORCID
Added: January 22, 2019
2010 journal article
ISFM AND AAFP CONSENSUS GUIDELINES Long-term use of NSAIDs in cats
JOURNAL OF FELINE MEDICINE AND SURGERY, 12(7), 521–538.
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Cat Diseases / drug therapy; Cats; Chronic Disease; Drug Administration Schedule / veterinary; International Agencies; Pain / drug therapy; Pain / veterinary; Societies, Medical; United States
TL;DR:
These guidelines have been drawn together by an expert panel, which have reviewed the current literature on long-term NSAID use in cats and other species, and developed guidance on their use based on this information.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
Item generation and design testing of a questionnaire to assess degenerative joint disease-associated pain in cats
Am J Vet Res, 71(12), 1417–1424.
MeSH headings : Aging / physiology; Animals; Bone and Bones / physiology; Bone and Bones / physiopathology; Cats; Databases, Factual; Humans; Joint Diseases / complications; Joint Diseases / physiopathology; Joint Diseases / veterinary; Orthopedics / veterinary; Pain / etiology; Pain / veterinary; Pain Measurement; Reference Values; Running / physiology; Surveys and Questionnaires; Veterinarians; Walking / physiology
TL;DR:
Behaviors relating to activity were substantially different between healthy cats and cats with signs of DJD-associated pain, and the preferred instrument design was identified.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: January 25, 2019
2010 review
LONG-TERM PAIN IN CATS How much do we know about this important welfare issue?
[Review of ]. JOURNAL OF FELINE MEDICINE AND SURGERY, 12(3), 188–199.
MeSH headings : Age Factors; Analgesics / therapeutic use; Animal Welfare; Animals; Biomedical Research; Cat Diseases / epidemiology; Cat Diseases / prevention & control; Cats; Diabetes Complications / veterinary; Evidence-Based Medicine; Joint Diseases / veterinary; Pain / veterinary; Pain Measurement / veterinary; Pain, Postoperative / veterinary; Research Design; United States; Veterinary Medicine
TL;DR:
The aim of this review is to summarise the current state of knowledge on long-term pain issues in cats, highlighting the obvious, and some not so obvious, causes; some aspects that warrant closer attention; the authors' ability to recognize pain and monitor how this impacts on quality of life; and today's treatment options.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
Long-term pain in cats: how much do we know about this important welfare issue?
Journal of Feline Medicine and Surgery, 12(3), 188–199.
Source: ORCID
Added: January 22, 2019
2010 journal article
Long-term use of NSAIDs in cats.
Compendium (Yardley, PA), 32(9), E2.
Source: ORCID
Added: January 22, 2019
2010 book
Manual de alteraciones musculoesqueleticas en pequeños animales.
Ediciones S.
Source: ORCID
Added: January 22, 2019
2010 journal article
Meniscal Mineralization in Domestic Cats
VETERINARY SURGERY, 39(5), 545–552.
MeSH headings : Age Factors; Animals; Calcinosis / diagnostic imaging; Calcinosis / pathology; Calcinosis / veterinary; Cat Diseases / diagnostic imaging; Cat Diseases / pathology; Cats; Female; Joint Diseases / diagnostic imaging; Joint Diseases / pathology; Joint Diseases / veterinary; Male; Menisci, Tibial / diagnostic imaging; Menisci, Tibial / pathology; Pain Measurement / veterinary; Prospective Studies; Radiography; Stifle / diagnostic imaging; Stifle / pathology
TL;DR:
Meniscal mineralization is a common condition in domestic cats and seems to indicate medial compartment DJD, which is a cause, or a consequence of joint degeneration, in dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 chapter
Osteoarthritis / Degenerative Joint Disease
In Nestle Purina PetCare Handbook of Canine and Feline Clinical Nutrition (1st ed., pp. 12–13). Wilmington, DE: The Gloyd Group.
Source: NC State University Libraries
Added: January 25, 2019
2010 article
Post-operative analgesia in the dog: a comparison of morphine, buprenorphine and pentazocine
WILEY-BLACKWELL PUBLISHING, INC COMMERCE PLACE, 350 MAIN ST, MALDEN 02148 ….
Source: ORCID
Added: January 22, 2019
2010 journal article
Preparation of canine and feline cadavers for surgical laboratories
Vet Surg, 39(2), 224–225.
MeSH headings : Animals; Cadaver; Cats / surgery; Dogs / surgery; Embalming / methods; Surgery, Veterinary / education; Surgery, Veterinary / methods
TL;DR:
A technique of cadaveric evisceration and freezing shortly after death is used to eliminate concerns about exposure of laboratory instructors and participants to formaldehyde.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2010 journal article
Proposed Definitions and Criteria for Reporting Time Frame, Outcome, and Complications For Clinical Orthopedic Studies in Veterinary Medicine
VETERINARY SURGERY, 39(8), 905–908.
MeSH headings : Animals; Clinical Protocols / standards; Data Collection; Information Dissemination / methods; Orthopedic Procedures / methods; Orthopedic Procedures / standards; Orthopedic Procedures / veterinary; Orthopedics / standards; Orthopedics / veterinary; Postoperative Complications / veterinary; Practice Guidelines as Topic / standards; Research Design / standards; Terminology as Topic; Time Factors; Treatment Outcome; Veterinary Medicine / standards
TL;DR:
Outcome, and Complications For Clinical Orthopedic Studies in Veterinary Medicine James L. Cook, DVM, PhD, Diplomate ACVS, Richard Evans, PhD and Michael G. Conzemius are reported on.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
Proposed definitions and criteria for reporting time frame, outcome, and complications for clinical orthopedic studies in veterinary medicine
Veterinary Surgery, 39(8), 905–908.
Source: ORCID
Added: January 22, 2019
2010 journal article
Review of the safety and efficacy of long-term NSAID use in the treatment of canine osteoarthritis
VETERINARY RECORD, 166(8), 226–230.
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / adverse effects; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Dog Diseases / drug therapy; Dogs; Drug Administration Schedule / veterinary; Osteoarthritis / drug therapy; Osteoarthritis / veterinary; Randomized Controlled Trials as Topic / veterinary; Treatment Outcome
TL;DR:
The balance of evidence for the efficacy of NSAIDs supports longer-term use of these agents for increased clinical effect and there is no indication in the literature that such an approach is associated with a reduction in safety, although robust data on the safety of long-term NSAID use are lacking in large numbers of dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 conference paper
Short term outcome of uncemented THR
Proceedings of the American College of Veterinary Surgeons Veterinary Symposium, 575–579.
Source: ORCID
Added: January 22, 2019
2010 journal article
The effects of body weight, body condition score, sex, and age on serum fructosamine concentrations in clinically healthy cats
Veterinary Clinical Pathology, 39(3), 322–328.
author keywords: Diabetes mellitus; feline; glycemic control; obesity
MeSH headings : Age Factors; Animals; Body Weight / physiology; Cat Diseases / blood; Cats / blood; Cats / physiology; Female; Fructosamine / blood; Male; Obesity / blood; Obesity / veterinary; Sex Factors
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
Use of non-steroidal anti-inflammatory drugs for the treatment of canine osteoarthritis
IN PRACTICE, 32(4), 126-+.
TL;DR:
The latest innovations, including those relating to drug delivery and pharmacokinetics, in the NSAIDs used in dogs with osteoarthritis, which often requires long-term treatment are discussed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
Use of non-steroidal anti-inflammatory drugs for the treatment of canine osteoarthritis
In Practice, 32(4), 126.
Source: ORCID
Added: January 22, 2019
2009 journal article
Effect of nonsteroidal anti-inflammatory drugs with varied cyclooxygenase-2 selectivity on cyclooxygenase protein and prostanoid concentrations in pyloric and duodenal mucosa of dogs
American Journal of Veterinary Research, 70(10), 1243–1249.
Contributors: J. Wooten n, A. Blikslager n , S. Marks n, J. Law n, E. Graeber n & B. Lascelles n
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Dogs; Drug Administration Schedule; Female; Gastric Mucosa / drug effects; Gastric Mucosa / metabolism; Gene Expression Regulation / drug effects; Male; Prostaglandin-Endoperoxide Synthases / metabolism; Prostaglandins / metabolism
TL;DR:
It is suggested that, for these experimental conditions, there were no differences among the preferential and selective COX-2 inhibitors with regard to adverse effects on the gastric and duodenal portions of the gastrointestinal tract of dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2009 journal article
Expression and activity of COX-1 and 2 and 5-LOX in joint tissues from dogs with naturally occurring coxofemoral joint osteoarthritis
Journal of Orthopaedic Research, 27(9), 1204–1208.
author keywords: canine; osteoarthritis; cyclooxygenase; lipoxygenase; eicosanoids
MeSH headings : Animals; Arachidonate 5-Lipoxygenase / metabolism; Arthroplasty, Replacement, Hip; Cyclooxygenase 1 / metabolism; Cyclooxygenase 2 / metabolism; Dinoprostone / metabolism; Disease Models, Animal; Dogs; Femur Head / metabolism; Femur Head / pathology; Hip Joint / enzymology; Hip Joint / pathology; Leukotriene B4 / metabolism; Osteoarthritis, Hip / metabolism; Osteoarthritis, Hip / pathology; Osteoarthritis, Hip / surgery; Synovial Membrane / enzymology; Synovial Membrane / pathology
TL;DR:
Both COX‐2 and 5‐LOX are appropriate targets for the management of pain associated with naturally occurring OA, evaluated in a naturally occurring canine model of secondary OA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2009 journal article
Rationale for and rational approach to using adjunctive drugs in the management of canine painful osteoarthritis
Compendium-Continuing Education for Veterinarians, 31(3A), 17–23.
Source: NC State University Libraries
Added: August 6, 2018
2009 journal article
The companion INTERVIEW
Journal of Small Animal Practice, 50(5), P26–26.
Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: August 6, 2018
2008 journal article
Amantadine in a multimodal analgesic regimen for alleviation of refractory osteoarthritis pain in dogs
JOURNAL OF VETERINARY INTERNAL MEDICINE, 22(1), 53–59.
author keywords: dog; nonsteroidal anti-inflammatory; owner; pain; subjective assessment
MeSH headings : Amantadine / administration & dosage; Amantadine / therapeutic use; Analgesics, Non-Narcotic / therapeutic use; Animals; Dog Diseases / drug therapy; Dog Diseases / etiology; Dogs; Double-Blind Method; Drug Administration Schedule / veterinary; Female; Male; Osteoarthritis / complications; Osteoarthritis / drug therapy; Osteoarthritis / veterinary; Pain / drug therapy; Pain / etiology; Pain / veterinary
TL;DR:
In dogs with osteoarthritic pain refractory to an NSAID, physical activity is improved by the addition of amantadine, which might be a useful adjunct therapy for the clinical management of canine osteoartritic pain.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2008 journal article
Antinociceptive and side-effects of hydromorphone after subcutaneous administration in cats
JOURNAL OF FELINE MEDICINE AND SURGERY, 11(2), 76–81.
MeSH headings : Analgesics, Opioid / administration & dosage; Analgesics, Opioid / adverse effects; Analgesics, Opioid / pharmacology; Animals; Cat Diseases / chemically induced; Cats / metabolism; Female; Hydromorphone / administration & dosage; Hydromorphone / adverse effects; Hydromorphone / pharmacology; Injections, Subcutaneous / veterinary; Male; Sialorrhea / chemically induced; Sialorrhea / veterinary; Skin Temperature / drug effects; Time Factors; Vomiting / chemically induced; Vomiting / veterinary
TL;DR:
Compared to previously published studies of IV and IM administration of hydromorphone, the SC route results in a slower onset of peak effect, a shorter duration of antinociception and is associated with more undesirable side-effects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2008 journal article
Cyclooxygenase expression and prostanoid production in pyloric and duodenal mucosae in dogs after administration of nonsteroidal anti-inflammatory drugs
American Journal of Veterinary Research, 69(4), 457–464.
Contributors: J. Wooten n, A. Blikslager* , K. Ryan*, S. Marks*, J. Law* & B. Lascelles
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Biopsy / veterinary; Blotting, Western / veterinary; Cross-Over Studies; Cyclooxygenase 1 / biosynthesis; Cyclooxygenase 2 / biosynthesis; Dogs / metabolism; Endoscopy / veterinary; Female; Gastric Mucosa / drug effects; Gastric Mucosa / enzymology; Gastric Mucosa / metabolism; Histocytochemistry / veterinary; Intestinal Mucosa / drug effects; Intestinal Mucosa / enzymology; Intestinal Mucosa / metabolism; Male; Prostaglandins / biosynthesis; Pyloric Antrum / drug effects; Pyloric Antrum / enzymology; Pyloric Antrum / metabolism; Random Allocation; Thromboxane B2 / metabolism
TL;DR:
In dogs, prostanoid synthesis was greater in pyloric mucosa than it was in duodenal mucosa, compared with the effects of a selective COX-2 NSAID.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2008 journal article
Efficacy of tolfenamic acid and meloxicam in the control of postoperative pain following ovariohysterectomy in the cat
Veterinary Anaesthesia and Analgesia, 35(6), 501–510.
MeSH headings : Analgesics / therapeutic use; Animals; Cats / surgery; Female; Hysterectomy / adverse effects; Hysterectomy / veterinary; Meloxicam; Ovariectomy / adverse effects; Ovariectomy / veterinary; Pain Measurement / veterinary; Pain, Postoperative / drug therapy; Pain, Postoperative / veterinary; Thiazines / therapeutic use; Thiazoles / therapeutic use; ortho-Aminobenzoates / therapeutic use
TL;DR:
Tolfenamic acid and meloxicam administered preoperatively provided a similar analgesic effect in the postoperative period lasting 24 hours, suggesting mechanical thresholds may be a better way of evaluating postoperative analgesia provided by nonsteroidal anti-inflammatory drugs in cats.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: August 6, 2018
2008 article
Evaluation of wraps covering the distal aspect of pelvic limbs for prevention of bacterial strike-through in an ex vivo canine model
Vince, K. J., Lascelles, B. D. X., Mathews, K. G., Altier, C., & Roe, S. C. (2008, June). VETERINARY SURGERY, Vol. 37, pp. 406–411.
MeSH headings : Administration, Cutaneous; Animals; Anti-Infective Agents, Local / pharmacology; Bacteria / drug effects; Bacteria / growth & development; Cadaver; Dogs / surgery; Hindlimb; Random Allocation; Surgical Wound Infection / prevention & control; Surgical Wound Infection / veterinary
TL;DR:
A distal leg wrap of Vetrap+sterile Coban is not effective in preventing bacterial strike-through in canine cadaveric pelvic limbs, and a sterile impermeable barrier must be incorporated into the distal legs wrap to prevent bacterialstrike-through.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2008 conference paper
Feline Osteoarthritis: What We Need to Know About the
MOBILITY SYMPOSIUM, 17.
Source: ORCID
Added: January 22, 2019
2008 conference paper
Leg defects and gait patterns on turkey bone biomechanical properties
POULTRY SCIENCE, 87, 58–58.
Event: POULTRY SCIENCE ASSOC INC 1111 N DUNLAP AVE, SAVOY, IL 61874-9604 USA
Source: ORCID
Added: January 22, 2019
2007 chapter
Anesthesia and analgesia for selected patients and procedures: Caner Patients
In T. W.J., T. Jc, & G. Ka (Eds.), Lumb & Jones Veterinary Anesthesia and Analgesia (4th ed., pp. 997–1008). Ames, Iowa: Blackwell Publishing.
Ed(s): T. W.J., T. Jc & G. Ka
Source: NC State University Libraries
Added: January 25, 2019
2007 journal article
Development of the short-form Glasgow Composite Measure Pain Scale (CMPS-SF) and derivation of an analgesic intervention score
ANIMAL WELFARE-POTTERS BAR THEN WHEATHAMPSTEAD-, 16, 97.
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
2007 journal article
Evaluation of a digitally integrated accelerometer-based activity monitor for the measurement of activity in cats(1)
VETERINARY ANAESTHESIA AND ANALGESIA, 35(2), 173–183.
author keywords: activity; assessment; feline; movement; video analysis
MeSH headings : Acceleration; Animals; Cats / physiology; Kinesiology, Applied / instrumentation; Male; Monitoring, Physiologic / instrumentation; Monitoring, Physiologic / veterinary; Motor Activity / physiology; Prospective Studies; Videotape Recording
TL;DR:
Output from an acceleration-based digitally integrated accelerometer correlated well with distance moved and mobility in freely moving cats provided the mobility threshold in the analysis software was > or = 6%.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2007 journal article
Evaluation of an accelerometer for at-home monitoring of spontaneous activity in dogs
AMERICAN JOURNAL OF VETERINARY RESEARCH, 68(5), 468–475.
MeSH headings : Animals; Dogs / physiology; Monitoring, Physiologic / instrumentation; Motor Activity / physiology; Time Factors; Videotape Recording
TL;DR:
Use of an accelerometer was adequate for at-home activity monitoring, an important end point in clinical trials of treatment for chronic disease, and provided information about daily activity that is unattainable by other methods.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2007 article
Evaluation of client-specific outcome measures and activity monitoring to measure pain relief in cats with osteoarthritis
JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 21, pp. 410–416.
author keywords: activity; degenerative joint disease; feline; owner; subjective assessment
TL;DR:
Both an AM and a CSOM system can detect behavior associated with pain relief in cats that are arthritic and Objective activity data might allow subjective assessment systems to be validated for use in clinical studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2007 journal article
Feline fibrosarcoma: perioperative management
Compendium, 29(12), 712-.
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
2007 journal article
Internal fixation of a femur fracture in an American bullfrog
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 230(8), 1201–1204.
MeSH headings : Animals; Animals, Wild; Bone Screws / veterinary; Bone Wires / veterinary; Femoral Fractures / surgery; Femoral Fractures / veterinary; Fracture Fixation, Internal / methods; Fracture Fixation, Internal / veterinary; Fracture Healing; Male; Rana catesbeiana / surgery; Treatment Outcome
TL;DR:
The applied internal fixation method provided effective long-term stabilization of the femur, allowed for normal movement, and enabled the bullfrog to be housed in an aquatic environment immediately after surgery.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2007 journal article
Kinetic evaluation of normal walking and jumping in cats, using a pressure-sensitive walkway
VETERINARY RECORD, 160(15), 512-+.
MeSH headings : Animals; Biomechanical Phenomena; Cats / physiology; Exercise Test / veterinary; Forelimb / physiology; Gait / physiology; Hindlimb / physiology; Pressure; Walking / physiology
TL;DR:
The kinetic parameters of the limbs of 23 normal, client-owned cats were evaluated by encouraging them to walk and jump normally on a pressure-sensitive walkway and jumping down generated significantly greater pvf and slightly greater vi than during walking.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2007 chapter
Management of chronic cancer pain
In S. Withrow & S. MacEwan (Eds.), Small Animal Clinical Oncology (pp. 291–306).
Ed(s): S. Withrow & S. MacEwan
Source: Crossref
Added: December 16, 2019
2007 review
Nonsteroidal anti-inflammatory drugs in cats: a review
[Review of ]. VETERINARY ANAESTHESIA AND ANALGESIA, 34(4), 228–250.
author keywords: cat; kinetics; non-steroidal anti-inflammatory drug; pain; pharmacology
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Cat Diseases / drug therapy; Cats; Pain / drug therapy; Pain / veterinary
TL;DR:
The evidence presented supports the short-term use of carprofen, flunixin, ketoprofen, meloxicam and tolfenamic acid as analgesics in cats and there were no data to support the safe chronic use of NSAIDs in cats.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2007 conference paper
Pharmacokinetic-pharmacodynamic modeling of morphine in dogs.
JOURNAL OF VETERINARY INTERNAL MEDICINE, 21(3), 617–617.
Event: WILEY-BLACKWELL PUBLISHING, INC COMMERCE PLACE, 350 MAIN ST, MALDEN 02148 …
Source: ORCID
Added: January 22, 2019
2007 chapter
Rehabilitation and palliative analgesia
In W. J. Tranquilli, T. Jc, & K. A. Grimm (Eds.), Lumb & Jones Veterinary Anesthesia and Analgesia (4th ed., pp. 697–704). Ames, Iowa: Blackwell Publishing.
Ed(s): W. Tranquilli, T. Jc & K. Grimm
Source: NC State University Libraries
Added: January 25, 2019
2007 journal article
Supportive care for the cancer patient
Source: ORCID
Added: January 22, 2019
2007 journal article
The latest developments in joint health support
Veterinary Technician, 28(8), A1–12.
Source: NC State University Libraries
Added: August 6, 2018
2007 journal article
Validity of goniometric joint measurements in cats
AMERICAN JOURNAL OF VETERINARY RESEARCH, 68(8), 822–826.
MeSH headings : Animals; Arthrometry, Articular / veterinary; Cats; Female; Forelimb; Hindlimb; Joints / physiology; Male; Reproducibility of Results
TL;DR:
Goniometric joint measurements in nonsedated and sedated cats are repeatable and valid, and did not differ significantly by measurement type, when comparing radiographic measurements with goniometric measurements in sedated and nonsedation cats.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2006 conference paper
Bile enhances barrier function by a COX-2 dependent mechanism in porcine duodenum
GASTROENTEROLOGY, 130(4), A241–A241.
Event: WB SAUNDERS CO-ELSEVIER INC INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300 …
Source: ORCID
Added: January 22, 2019
2006 journal article
Comparison of measurements obtained by use of an electrogoniometer and a universal plastic goniometer for the assessment of joint motion in dogs
AMERICAN JOURNAL OF VETERINARY RESEARCH, 67(12), 1974–1979.
MeSH headings : Animals; Arthrometry, Articular / instrumentation; Arthrometry, Articular / methods; Arthrometry, Articular / veterinary; Breeding; Dogs / classification; Dogs / physiology; Joints / physiology; Observer Variation; Reproducibility of Results
TL;DR:
There was higher variability for the EG than for the UG, and an EG cannot be recommended for use, and a UG is reliable for obtaining measurements in German Shepherd Dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2006 conference paper
Early weaning stress predisposes adult pigs to stress-induced colonic barrier dysfunction: a novel model for stress-induced gastrointestinal disorders in humans
Gastroenterology, 130(4), A89–A89.
Event: WB SAUNDERS CO-ELSEVIER INC INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300 …
Source: ORCID
Added: January 22, 2019
2006 article
Evaluation of a pressure walkway system for measurement of vertical limb forces in clinically normal dogs
Lascelles, B. D. X., Roe, S. C., Smith, E., Reynolds, L., Markham, J., Marcellin-Little, D., … Budsberg, S. C. (2006, February). AMERICAN JOURNAL OF VETERINARY RESEARCH, Vol. 67, pp. 277–282.
MeSH headings : Animals; Biomechanical Phenomena; Body Weight; Dog Diseases / physiopathology; Dogs; Gait / physiology; Health; Lameness, Animal / physiopathology; Male
TL;DR:
Values for GRFs varied between the FP and PSW, however, data derived by use of PSW were consistent and could be used to evaluate kinetic variables over time in the same dog.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2006 journal article
Financial and welfare implications of immediate euthanasia of casualty nursery pigs
Journal of Swine Health Production, 14(1), 25–34.
Source: NC State University Libraries
Added: January 25, 2019
2006 chapter
Tumours of the musculoskeletal system
In J. E. F. Houlton, J. L. Cook, I. Jf, & S. J. Langley-Hobbs (Eds.), BSAVA Manual of Lameness (pp. 128–134). Cheltenham, UK: BSAVA Publications.
Ed(s): J. Houlton, J. Cook, I. Jf & S. Langley-Hobbs
Source: NC State University Libraries
Added: January 25, 2019
2005 journal article
AAHA senior care guidelines for dogs and cats
Journal of the American Animal Hospital Association, 41(2), 81–91.
Source: ORCID
Added: January 22, 2019
2005 journal article
Assessment of a von Frey device for evaluation of the antinociceptive effects of morphine and its application in pharmacodynamic modeling of morphine in dogs
American Journal of Veterinary Research, 66(9), 1616–1622.
MeSH headings : Analgesics / therapeutic use; Animals; Chromatography, High Pressure Liquid / veterinary; Dogs / metabolism; Drug Design; Evaluation Studies as Topic; Morphine / blood; Morphine / therapeutic use; Pain / drug therapy; Pain Measurement / instrumentation; Pain Measurement / methods; Pain Measurement / veterinary; Statistics, Nonparametric
TL;DR:
Data suggest that, in dogs, evaluation of the antinociceptive effect and pharmacodynamic modeling of a dose of morphine sulfate (1 mg/kg, i.v.) can be successfully achieved by use of a von Frey device.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2005 journal article
Current attitudes to, and use of, peri-operative analgesia in dogs and cats by veterinarians in New Zealand
NEW ZEALAND VETERINARY JOURNAL, 53(3), 193–202.
author keywords: dogs; cats; analgesia; veterinarians; attitudes; New Zealand
MeSH headings : Analgesia / statistics & numerical data; Analgesia / veterinary; Analgesics, Opioid / administration & dosage; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Attitude of Health Personnel; Carbazoles / administration & dosage; Cats / physiology; Cats / surgery; Dogs / physiology; Dogs / surgery; Female; Humans; Male; Morphine / administration & dosage; New Zealand / epidemiology; Pain, Postoperative / prevention & control; Pain, Postoperative / veterinary; Practice Patterns, Physicians' / statistics & numerical data; Preoperative Care / veterinary; Surveys and Questionnaires; Veterinarians / statistics & numerical data
TL;DR:
Results indicated a relatively high use of peri-operative analgesia, including both pre-emptive and multi-modal analge- sia, in cats and dogs, although there was still some disparity between the perception of how painful a procedure was and the consequent use of pain relief.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2005 journal article
Gastrointestinal tract perforation in dogs treated with a selective cyclooxygenase-2 inhibitor: 29 cases (2002-2003)
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 227(7), 1112–1117.
Contributors: B. Lascelles n, A. Blikslager n , S. Fox n & D. Reece n
MeSH headings : Acute Disease; Adrenal Cortex Hormones / therapeutic use; Adverse Drug Reaction Reporting Systems; Animals; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Chronic Disease; Cyclooxygenase Inhibitors / adverse effects; Cyclooxygenase Inhibitors / therapeutic use; Dog Diseases / chemically induced; Dog Diseases / mortality; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Intestinal Perforation / chemically induced; Intestinal Perforation / mortality; Intestinal Perforation / veterinary; Pain / drug therapy; Pain / veterinary; Retrospective Studies; Sulfonamides / adverse effects; Sulfonamides / therapeutic use; Survival Rate
TL;DR:
In dogs with gastrointestinal tract perforation and that had been treated with deracoxib, perforations was most likely attributable to a number of factors, and derac oxib should only be used at approved dosages.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2005 journal article
Guidelines for safe and effective use of NSAIDs in dogs
Veterinary Therapeutics, 6(3), 237.
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
2005 journal article
Improved survival associated with postoperative wound infection in dogs treated with limb-salvage surgery for osteosarcoma
ANNALS OF SURGICAL ONCOLOGY, 12(12), 1073–1083.
author keywords: osteosarcoma; canine; limb salvage; postoperative infection
MeSH headings : Animals; Bone Neoplasms / drug therapy; Bone Neoplasms / epidemiology; Bone Neoplasms / mortality; Bone Neoplasms / pathology; Chemotherapy, Adjuvant; Dogs; Female; Hindlimb; Limb Salvage; Male; Neoplasm Recurrence, Local; Osteosarcoma / drug therapy; Osteosarcoma / epidemiology; Osteosarcoma / mortality; Osteosarcoma / pathology; Proportional Hazards Models; Radius; Surgical Wound Infection / epidemiology; Survival Analysis
TL;DR:
In dogs with osteosarcoma treated with limb-salvage surgery, infection has a positive influence on survival, as does a smaller initial length of radius involved and lower body weight.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2005 journal article
Improvement of the lung function of horses with heaves by treatment with a botanical preparation for 14 days
The Veterinary Record, 157, 733–736.
Source: ORCID
Added: January 22, 2019
2005 journal article
PK-PD modeling of buprenorphine in cats: intravenous and oral transmucosal administration1
Journal of Veterinary Pharmacology and Therapeutics, 28(5), 453–460.
MeSH headings : Administration, Buccal; Animals; Area Under Curve; Body Temperature; Buprenorphine / administration & dosage; Buprenorphine / blood; Buprenorphine / pharmacokinetics; Buprenorphine / pharmacology; Cats / metabolism; Cross-Over Studies; Female; Injections, Intravenous / veterinary; Male; Models, Statistical; Narcotic Antagonists / administration & dosage; Narcotic Antagonists / blood; Narcotic Antagonists / pharmacokinetics; Narcotic Antagonists / pharmacology
TL;DR:
Overall, OTM administration of buprenorphine is as effective as i.v. treatment and offers a simple, noninvasive method of administration which produces thermal antinociception for up to 6 h in cats.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: July 28, 2019
2005 journal article
Pharmacokinetics and Pharmacodynamics of Morphine in Dogs following Intravenous Infusion and Multiple Intravenous Doses
American Journal of Veterinary Research, 28, 371–376.
Source: NC State University Libraries
Added: July 11, 2019
2005 journal article
Pharmacokinetics of morphine and plasma concentrations of morphine-6-glucuronide following morphine administration to dogs
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 28(4), 371–376.
MeSH headings : Administration, Oral; Analgesics, Opioid / administration & dosage; Analgesics, Opioid / blood; Analgesics, Opioid / pharmacokinetics; Animals; Cross-Over Studies; Delayed-Action Preparations; Dogs / metabolism; Female; Injections, Intravenous / veterinary; Male; Morphine / administration & dosage; Morphine / blood; Morphine / pharmacokinetics; Morphine Derivatives / blood
TL;DR:
Computer simulations concluded morphine sulfate administered 0.5 mg/kg intravenously every 2 h would maintain morphine plasma concentrations consistent with analgesic plasma concentrations in humans and oral morphine is poorly and erratically absorbed in dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2005 journal article
Pharmocokinetic and pharmacodynamic evaluation of intravenous morphine in dogs
Veterinary Anaesthesia and Analgesia, 32(4), 2–2.
Source: ORCID
Added: January 22, 2019
2005 journal article
The effects of inhibiting cytochrome P450 3A, p-glycoprotein, and gastric acid secretion on the oral bioavailability of methadone in dogs
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 28(5), 461–466.
MeSH headings : ATP Binding Cassette Transporter, Subfamily B, Member 1 / drug effects; Administration, Oral; Animals; Area Under Curve; Biological Availability; Cross-Over Studies; Cytochrome P-450 CYP3A / drug effects; Cytochrome P-450 CYP3A Inhibitors; Dogs / metabolism; Enzyme Inhibitors / administration & dosage; Enzyme Inhibitors / pharmacology; Female; Gastric Acid / metabolism; Injections, Intravenous / veterinary; Ketoconazole / administration & dosage; Ketoconazole / pharmacology; Male; Methadone / administration & dosage; Methadone / blood; Methadone / pharmacokinetics; Omeprazole / administration & dosage; Omeprazole / pharmacology; Proton Pump Inhibitors
TL;DR:
In contrast to its pharmacokinetics humans, methadone has a short elimination half-life, rapid clearance, and low oral bioavailability in dogs and the extent of absorption is not affected by inhibition of CYP3A, p-gp, and gastric acid secretion.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2005 article
Use of a von Frey device for evaluation of pharmacokinetics and pharmacodynamics of morphine after intravenous administration as an infusion or multiple doses in dogs
KuKanich, B., Lascelles, B. D. X., & Papich, M. G. (2005, November). AMERICAN JOURNAL OF VETERINARY RESEARCH, Vol. 66, pp. 1968–1974.
MeSH headings : Analgesics, Opioid / administration & dosage; Analgesics, Opioid / blood; Analgesics, Opioid / pharmacokinetics; Analgesics, Opioid / pharmacology; Animals; Area Under Curve; Cross-Over Studies; Dogs / blood; Female; Half-Life; Hematocrit / veterinary; Infusions, Intravenous / veterinary; Injections, Intravenous / veterinary; Male; Morphine / administration & dosage; Morphine / blood; Morphine / pharmacokinetics; Morphine / pharmacology; Pain Measurement / veterinary; Random Allocation; Statistics, Nonparametric
TL;DR:
Evaluating the pharmacokinetics and pharmacodynamics of morphine after IV administration as an infusion or multiple doses in dogs by use of a von Frey (vF) device maintained significant antinociception in dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2005 journal article
Use of hinged transarticular external fixation for adjunctive joint stabilization in dogs and cats: 14 cases (1999-2003)
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 227(4), 586–591.
MeSH headings : Animals; Cats / injuries; Cats / surgery; Dogs / injuries; Dogs / surgery; External Fixators / veterinary; Female; Male; Range of Motion, Articular; Retrospective Studies; Stifle / injuries; Stifle / surgery; Tarsal Joints / injuries; Tarsal Joints / surgery; Treatment Outcome; Wound Healing
TL;DR:
Hinged transarticular external fixation in animals with traumatic joint instability provided adjunctive joint stabilization during healing and protection of the primary repair and maintained joint motion during healing, resulting in early weight bearing of the affected limb.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2005 journal article
Validation of a high-pressure liquid chromatography and fluorescence polarization immunoassay for the determination of methadone in canine plasma
THERAPEUTIC DRUG MONITORING, 27(3), 389–392.
author keywords: HPLC; FPIA; dog; concentration
MeSH headings : Animals; Chromatography, High Pressure Liquid / methods; Dogs; Female; Fluorescence Polarization Immunoassay / methods; Male; Methadone / blood
TL;DR:
FPIA provides a rapid, sensitive, and specific measurement of methadone in canine plasma following oral and intravenous administration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2004 journal article
Antinociceptive Effects of Hydromorphone, Butorphanol, or the Combination in Cats
Journal of Veterinary Internal Medicine, 18(2), 190–195.
TL;DR:
The present study suggests that the combination of butorphanol and a pure OP3 (mu) receptor agonist clinically does not produce increased analgesia and indeed may result in decreased analgesia.
(via Semantic Scholar)
Source: ORCID
Added: January 22, 2019
2004 article
Antinociceptive effects of hydromorphone, butorphanol, or the combination in cats
JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 18, pp. 190–195.
author keywords: agonist; agonist-antagonist; opioid; pain; thermal thresholds
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2004 journal article
Bilateral rostral maxillectomy and nasal planectomy for large rostral maxillofacial neoplasms in six dogs and one cat
JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 40(2), 137–146.
MeSH headings : Animals; Carcinoma, Squamous Cell / surgery; Carcinoma, Squamous Cell / veterinary; Cat Diseases / surgery; Cats; Dog Diseases / surgery; Dogs; Female; Fibrosarcoma / surgery; Fibrosarcoma / veterinary; Male; Maxillary Neoplasms / surgery; Maxillary Neoplasms / veterinary; Neoplasm Recurrence, Local / surgery; Neoplasm Recurrence, Local / veterinary; Postoperative Complications / epidemiology; Postoperative Complications / veterinary; Surgery, Oral / methods; Treatment Outcome
TL;DR:
This paper describes in detail an aggressive rostral maxillectomy procedure in one cat and six dogs, and the postoperative complications and outcomes are reported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2004 report
Current viewpoints and guidelines on safe and effective use of non-steroidal anti-inflammatory drugs in companion animals
Pfizer Animal Health.
Source: NC State University Libraries
Added: January 25, 2019
2004 journal article
Guidelines for safe and effective use of non-steroidal anti-inflammatory drugs in dogs
Pfizer Animal Health Technical Bulletin.
Source: NC State University Libraries
Added: January 25, 2019
2004 journal article
Intraoperative extracorporeal irradiation for limb sparing in 13 dogs
Veterinary Surgery, 33(5), 446–456.
Source: ORCID
Added: January 22, 2019
2004 chapter
Manejo del dolor cronico en pequeňos animals: tratamiento multimodal
In P. E. Otero (Ed.), Dolor Evaluacion y Tratamiento en Pequenos Animales (Pain Evaluation and Treatment in Small Animals) (pp. 137–149). Buenos Aires, Republica Argentina: Inter-Medica.
Ed(s): P. Otero
Source: NC State University Libraries
Added: January 25, 2019
2004 journal article
Perioperative pain management in small animals
Veterinary Medicine, 99(5), A1–16.
Source: NC State University Libraries
Added: August 6, 2018
2004 chapter
Perspectivas futures en el manejo del dolor
In P. E. Otero (Ed.), Dolor Evaluacion y Tratamiento en Pequeňos Animales (Pain Evaluation and Treatment in Small Animals) (pp. 239–243). Buenos Aires, Republica Argentina: Inter-Medica.
Ed(s): P. Otero
Source: NC State University Libraries
Added: January 25, 2019
2004 journal article
Phalangeal fractures and metacarpophalangeal luxations subsequent to post-traumatic osteomyelitis and cellulitis in a dog
JOURNAL OF SMALL ANIMAL PRACTICE, 45(7), 368–371.
MeSH headings : Amputation, Surgical / veterinary; Animals; Cellulitis / complications; Cellulitis / diagnosis; Cellulitis / veterinary; Diagnosis, Differential; Dog Diseases / diagnosis; Dog Diseases / diagnostic imaging; Dog Diseases / surgery; Dogs / injuries; Forelimb / diagnostic imaging; Forelimb / injuries; Forelimb / surgery; Fractures, Bone / complications; Fractures, Bone / diagnosis; Fractures, Bone / veterinary; Joint Dislocations / complications; Joint Dislocations / diagnosis; Joint Dislocations / veterinary; Metacarpophalangeal Joint / diagnostic imaging; Metacarpophalangeal Joint / injuries; Metacarpophalangeal Joint / surgery; Osteomyelitis / complications; Osteomyelitis / diagnosis; Osteomyelitis / veterinary; Radiography
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2004 article
Use of thermal threshold response to evaluate the antinociceptive effects of butorphanol in cats
Lascelles, B. D. X., & Robertson, S. A. (2004, August). AMERICAN JOURNAL OF VETERINARY RESEARCH, Vol. 65, pp. 1085–1089.
MeSH headings : Analgesics / pharmacology; Animals; Butorphanol / pharmacology; Cats / physiology; Cross-Over Studies; Hot Temperature; Injections, Intravenous / veterinary; Pain Measurement / methods; Pain Measurement / veterinary; Pain Threshold / drug effects; Skin Temperature; Time Factors
TL;DR:
Results obtained by use of a thermal stimulus indicated that the duration of antinociceptive action of butorphanol was 90 minutes and there was no dose-response relationship in cats.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2003 book
British Small Animal Veterinary Association Manual of Oncology
(2nd ed.). Cheltenham, UK: BSAVA Publications.
Ed(s): J. Dobson & B. Lascelles
Source: NC State University Libraries
Added: July 11, 2019
2003 book
British Small Animal Veterinary Association Manual of Oncology (Japanese Translation)
(2nd ed.). Cheltenham, UK: BSAVA Publications.
Ed(s): J. Dobson & B. Lascelles
Source: NC State University Libraries
Added: March 9, 2021
2003 journal article
Changes in thermal threshold response in eight cats after administration of buprenorphine, butorphanol and morphine
VETERINARY RECORD, 153(15), 462–465.
MeSH headings : Analgesics, Opioid / administration & dosage; Analgesics, Opioid / pharmacology; Animals; Body Temperature Regulation / drug effects; Buprenorphine / administration & dosage; Buprenorphine / pharmacology; Butorphanol / administration & dosage; Butorphanol / pharmacology; Cats / physiology; Female; Injections, Intramuscular / veterinary; Male; Morphine / administration & dosage; Morphine / pharmacology; Single-Blind Method
TL;DR:
Thermal thresholds were measured in eight cats after the intramuscular administration of morphine, buprenorphine or butorphanol, doses commonly used in clinical practice, and there was no significant change in thermal threshold after the injection of saline.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2003 journal article
Combined dorsolateral and intraoral approach for the resection of tumors of the maxilla in the dog
Journal of the American Animal Hospital Association, 39(3), 294–305.
MeSH headings : Animals; Carcinoma, Squamous Cell / surgery; Carcinoma, Squamous Cell / veterinary; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Dog Diseases / surgery; Dogs; Female; Fibrosarcoma / surgery; Fibrosarcoma / veterinary; Intraoperative Care / veterinary; Male; Maxillary Neoplasms / surgery; Maxillary Neoplasms / veterinary; Melanoma / surgery; Melanoma / veterinary; Neoplasm Recurrence, Local / veterinary; Osteosarcoma / surgery; Osteosarcoma / veterinary; Postoperative Complications / veterinary; Records / veterinary; Retrospective Studies; Surgery, Oral / methods; Tomography, X-Ray Computed / veterinary
TL;DR:
A combined dorsal and intraoral approach for maxillectomy for tumors involving tissues more caudal to the third premolar with an improvement in outcome over previously reported studies is described.
(via Semantic Scholar)
Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: August 6, 2018
2003 journal article
Comparison of the pharmacokinetics and thermal antinociceptive pharmacodynamics of 20 μg kg(-1) buprenorphine administered sublingually or intravenously in cats
Vet Anaesth Analg, 30(2), 108.
TL;DR:
This study aimed to assess and compare the pharmacokinetics and pharmacodynamics of sublingual (S-L) and IV administration of BUP, and found that S-L or IV provided antinociception between 30 and 360 minutes after administration.
(via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: January 25, 2019
2003 journal article
Effect of 0.1, 0.2, 0.4, and 0.8 mg kg- 1 of intravenous butorphanol on thermal antinociception in cats
Veterinary Anaesthesia and Analgesia, 30(2), 107–107.
Source: ORCID
Added: January 22, 2019
2003 journal article
Effect of low-dose ketamine on thermal thresholds in cats
Vet Anaesth Analg, 30(2), 109.
TL;DR:
It is suggested that K caused a delayed onset hyperalgesia in cats, which exhibited normal activity, but responses to thermal stimuli were exaggerated.
(via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: January 25, 2019
2003 journal article
Evolving roles if NSAIDs in clinical practice
Veterinary Medicine, 98(8), A1–8.
Source: NC State University Libraries
Added: August 6, 2018
2003 book
Practical pain relief for dogs and cats
Blackwell Science.
Source: ORCID
Added: January 22, 2019
2003 chapter
Principles of oncological surgery
In J. Dobson & B. D. X. Lascelles (Eds.), BSAVA Manual of Oncology (2nd ed., pp. 73–85). Cheltenham, UK: BSAVA Publications.
Ed(s): J. Dobson & B. Lascelles
Source: NC State University Libraries
Added: January 25, 2019
2003 chapter
Relief of chronic cancer pain
In J. Dobson & B. D. X. Lascelles (Eds.), BSAVA Manual of Oncology (2nd ed., pp. 137–151). Cheltenham, UK: BSAVA Publications.
Ed(s): J. Dobson & B. Lascelles
Source: NC State University Libraries
Added: January 25, 2019
2003 journal article
Surgical treatment of right-sided renal lymphoma with invasion of the caudal vena cava
JOURNAL OF SMALL ANIMAL PRACTICE, 44(3), 135–138.
MeSH headings : Animals; Death, Sudden / veterinary; Diagnosis, Differential; Dog Diseases / diagnosis; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Dog Diseases / surgery; Dogs; Kidney Neoplasms / diagnosis; Kidney Neoplasms / pathology; Kidney Neoplasms / surgery; Kidney Neoplasms / veterinary; Lymphoma / diagnosis; Lymphoma / pathology; Lymphoma / surgery; Lymphoma / veterinary; Male; Radiography; Radionuclide Imaging; Surgery, Veterinary / methods; Ultrasonography; Vena Cava, Inferior / surgery
TL;DR:
An eight-year-old, male castrated basset hound presenting with a three-month history of lethargy was examined and the renal mass was diagnosed as lymphoma on histopathology, and the dog was euthanased.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2002 journal article
Drug therapy for acute and chronic pain in the cat.
International Journal of Pharmaceutical Compounding, 6(5), 338–343.
Source: ORCID
Added: January 22, 2019
2002 journal article
Surgical reconstruction of ectrodactyly deformity in four dogs-(Vet Comp Orthop Traumatol 2001; 14: 201-9)-Reply
VETERINARY AND COMPARATIVE ORTHOPAEDICS AND TRAUMATOLOGY, 15(2), VV.
Source: ORCID
Added: January 22, 2019
2002 journal article
Surgical trauma and chronically painful conditions--within our comfort level but beyond theirs?
J Am Vet Med Assoc, 221(2), 215–222.
MeSH headings : Aging / physiology; Animal Welfare; Animals; Animals, Domestic / surgery; Chronic Disease / therapy; Dogs; Ethics; Longevity; Pain, Postoperative / therapy; Pain, Postoperative / veterinary; Wounds and Injuries / therapy; Wounds and Injuries / veterinary
TL;DR:
As veterinarians, the authors constantly are being presented with new medical and surgical techniques that lead to more substantial interventions for animals, resulting in greater longevi-ty.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2001 journal article
Combined omental pedicle grafts and thoracodorsal axial pattern flaps for the reconstruction of chronic, nonhealing axillary wounds in cats
Veterinary Surgery, 30(4), 380–385.
MeSH headings : Animals; Axilla; Cat Diseases / surgery; Cats / injuries; Female; Male; Omentum / transplantation; Prospective Studies; Surgical Flaps / veterinary; Treatment Outcome; Wounds and Injuries / surgery; Wounds and Injuries / veterinary
TL;DR:
The use of an omental pedicle graft in combination with a thoracodorsal axial pattern flap is the first consistently successful 1-step technique for the management of chronic nonhealing axillary wounds in cats.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: January 22, 2019
2001 chapter
Drugs used in the treatment of the musculoskeletal system and joints
In Y. Bishop (Ed.), The Veterinary Formulary (5th ed., pp. 469–488). London: Pharmaceutical Press.
Ed(s): Y. Bishop
Source: NC State University Libraries
Added: January 25, 2019
2001 journal article
Evaluation of the clinical efficacy of meloxicam in cats with painful locomotor disorders
Journal of Small Animal Practice, 42(12), 587–593.
Source: ORCID
Added: January 22, 2019
2001 journal article
Morphine, pethidine and buprenorphine disposition in the cat
Journal of Veterinary Pharmacology and Therapeutics, 24(6), 391–398.
Source: ORCID
Added: January 22, 2019
2001 journal article
Preemptive analgesia: managing pain before it begins
Veterinary Medicine, 478–492.
Source: NC State University Libraries
Added: January 25, 2019
2001 journal article
Surgical reconstruction of ectrodactyly deformity in four dogs
Veterinary and Comparative Orthopaedics and Traumatology, 14(04), 201–209.
Source: ORCID
Added: January 22, 2019
2000 chapter
Management of post-operative and other acute pain
In P. Flecknell & A. E. Waterman-Pearson (Eds.), Pain Management in Animals (pp. 80–146).
Ed(s): P. Flecknell & A. Waterman-Pearson
Sources: NC State University Libraries, NC State University Libraries
Added: January 25, 2019
2000 chapter
Management of postoperative and other acute pain
In Pain management in animals (pp. 81–145). Elsevier.
Source: ORCID
Added: January 22, 2019
2000 chapter
Pain assessment
In Pain management in animals (pp. 53–79). Elsevier.
Source: ORCID
Added: January 22, 2019
2000 chapter
Pain recognition and pain assessment
In P. Flecknell & A. E. Waterman-Pearson (Eds.), Pain management in animals (pp. 53–80). London, UK: WB Saunders.
Ed(s): P. Flecknell & A. Waterman-Pearson
Source: NC State University Libraries
Added: January 25, 2019
2000 journal article
Practical peri-operative analgesia - the present and the future
Walthum Focus.
Source: NC State University Libraries
Added: January 25, 2019
2000 journal article
Preemptive analgesia: An aid to postoperative pain control
The Journal of Pain, 1(2), 93–95.
Source: ORCID
Added: January 22, 2019
2000 journal article
Squamous cell carcinoma of the nasal planum in 17 dogs
Vet Rec, 147(17), 473–476.
MeSH headings : Animals; Carcinoma, Squamous Cell / pathology; Carcinoma, Squamous Cell / therapy; Carcinoma, Squamous Cell / veterinary; Dog Diseases / pathology; Dog Diseases / radiotherapy; Dog Diseases / surgery; Dogs; Female; Male; Nose Neoplasms / pathology; Nose Neoplasms / therapy; Nose Neoplasms / veterinary; Radiotherapy, Adjuvant / veterinary; Retrospective Studies; Treatment Outcome
TL;DR:
The dogs' prognosis was adversely affected by the interval between their initial examination and treatment, but there was no apparent association between the histological grade of the tumour and the clinical outcome.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: January 25, 2019
2000 journal article
Use of omental pedicle grafts in the management of non-healing axillary wounds in 10 cats.
European Journal of Companion Animal Practice, 10(1), 29–35.
Source: ORCID
Added: January 22, 2019
1999 journal article
Current British veterinary attitudes to perioperative analgesia for dogs
Vet Rec, 145(4), 95–99.
MeSH headings : Analgesia / veterinary; Analgesics / therapeutic use; Animal Welfare; Animals; Attitude of Health Personnel; Cat Diseases / therapy; Cats; Data Collection; Dog Diseases / therapy; Dogs; Female; Humans; Male; Pain / veterinary; Veterinary Medicine
TL;DR:
In general, women and more recent graduates assigned higher pain scores to the procedures and were more likely to treat the pain with analgesics, but relatively few appear to use combinations of different classes of analgesics either before or after operations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: NC State University Libraries, Crossref, ORCID
Added: January 22, 2019
1999 journal article
Principles of oncological surgery
In Practice, 21(4), 163.
Source: ORCID
Added: January 22, 2019
1998 journal article
Efficacy and kinetics of carprofen, administered preoperatively or postoperatively, for the prevention of pain in dogs undergoing ovariohysterectomy
Veterinary Surgery, 27(6), 568–582.
Source: ORCID
Added: January 22, 2019
1998 journal article
Rhabdomyosarcoma of the tongue in a dog
Journal of Small Animal Practice, 39(12), 587–591.
Source: ORCID
Added: January 22, 2019
1998 journal article
Treatment of canine nasal aspergillosis with a new non-invasive technique. Failure with enilconazole
Journal of Small Animal Practice, 39(5), 223–226.
Source: ORCID
Added: January 22, 2019
1998 journal article
Use of omental pedicle grafts in the management of non-healing axillary wounds in 10 cats
Journal of Small Animal Practice, 39(10), 475–480.
Source: ORCID
Added: January 22, 2019
1997 journal article
Analgesia in cats
In Practice, 4.
TL;DR:
Questions are asked and information is provided which will encourage the routine use of analgesics in cats as well as dogs following surgery.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: January 25, 2019
1997 journal article
Post-operative central hypersensitivity and pain: the pre-emptive value of pethidine for ovariohysterectomy
Pain, 73(3), 461–471.
author keywords: pre-emptive; analgesia; dog; opioid; ovariohysterectomy; central hypersensitivity
MeSH headings : Abdomen; Analgesics, Opioid / therapeutic use; Analysis of Variance; Animals; Dogs; Double-Blind Method; Female; Hypersensitivity / etiology; Hysterectomy / adverse effects; Hysterectomy / veterinary; Meperidine / therapeutic use; Ovariectomy / adverse effects; Ovariectomy / veterinary; Pain Threshold; Pain, Postoperative / prevention & control; Pain, Postoperative / veterinary; Radius; Stress, Mechanical; Tibia
TL;DR:
It is shown that pethidine has a positive benefit in terms of post‐operative outcome measures, when administered pre‐operatively, possibly as a result of blocking or preventing the development of central sensitisation following surgical stimulation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 25, 2019
1997 journal article
Survey of attitudes in UK veterinary surgeons to perioperative analgesia
Journal of Veterinary Anaesthesia (United Kingdom).
Source: ORCID
Added: January 22, 2019
1996 journal article
Advances in the control of pain in animals
Veterinary Annual (United Kingdom).
Source: ORCID
Added: January 22, 2019
1996 journal article
Survey of peri-operative analgesic use in small animals
Journal of Small Animal Practice, 37(10), 479–479.
Source: ORCID
Added: January 22, 2019
1995 journal article
Carprofen as an analgesic for postoperative pain in cats: dose titration and assessment of efficacy in comparison to pethidine hydrochloride
Journal of Small Animal Practice, 36(12), 535–541.
Source: ORCID
Added: January 22, 2019
1995 journal article
Central sensitization as a result of surgical pain: investigation of the pre-emptive value of pethidine for ovariohysterectomy in the rat
Pain, 62(2), 201–212.
Source: ORCID
Added: January 22, 2019
1995 journal article
Survey of perioperative analgesic use in small animals
Veterinary Record, 137(26), 676–676.
Source: ORCID
Added: January 22, 2019
1994 journal article
Postoperative analgesic and sedative effects of carprofen and pethidine in dogs.
The Veterinary Record, 134(8), 187–191.
Source: ORCID
Added: January 22, 2019
journal article
Advances in Pain Management: use of wound analgesic catheters
Lascelles, B. D. X., & CertVA, D. S. A. S.
Source: ORCID
Added: January 22, 2019
journal article
Fact Sheet for Global Year Against Joint Pain, International Association for the Study of Pain
Lascelles, B. D. X. http://iasp.files.cms-plus.com/Content/ContentFolders/GlobalYearAgainstPain2/2016/FactSheets/English/9.%20Joint%20Pain%20in%20Pet%20Dogs%20and%20Cats.pdf
Source: NC State University Libraries
Added: January 25, 2019
journal article
Journal of feline medicine and surgery ClinicalPractice
Sparkes, A. H., Scherk, M., Gunn-Moore, D., Kruth, S., Lester, S., Malik, R., … others.
Source: ORCID
Added: January 22, 2019
journal article
MANAGEMENT OF CANCER PAIN
Lascelles, B. D. X.
Source: ORCID
Added: January 22, 2019
journal article
Monitoring of Progress After Total Hip Replacement in Dogs Using Walkway™
Friere-Gonzalez, M., & Lascelles, B. D. X.
Source: ORCID
Added: January 22, 2019
journal article
Owner Assessment of Quality of Life in Cats, and Its Relationship to Degenerative Joint Disease
Gruen, M. E., Benito, J., Thomson, A., Simpson, W., & Lascelles, B. D. X. ACVB/AVSAB, 18.
Source: ORCID
Added: January 22, 2019
conference paper
Risk--Benefit Decision Making in the Long-term Use of NSAIDs for Canine Osteoarthritis
Lascelles, B. D. X., & CertVA, D. S. A. S. PAIN MANAGEMENT Symposium 2013, 5.
Source: ORCID
Added: January 22, 2019
journal article
Stress in owned cats: behavioural changes and welfare implications 577
Amat, M., Camps, T., Manteca, X., Roomp, K., Rand, J., Black, V., … others.
Source: ORCID
Added: January 22, 2019
journal article
WE Morgan Morrow, Department of Animal Science, North Carolina State University
Lascelles, D.
Source: ORCID
Added: January 22, 2019
journal article
WOUND ANALGESIC CATHETER
Lascelles, B. D. X.
Source: ORCID
Added: January 22, 2019
Employment
Updated: April 21st, 2017 18:10
2002 - present
North Carolina State University Raleigh, NC, US
Professor, Surgery and Pain Management
College of Veterinary Medicine
Education
Updated: April 21st, 2017 18:09
1991 - 1995
University of Bristol Bristol, Bristol, GB
PhD
School of Medicine
1985 - 1991
University of Bristol Bristol, Bristol, GB
BVSc
School of Veterinary Medicine
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