Duncan X. Lascelles
Works (381)
Updated: November 24th, 2024 05:16
2024 journal article
2024 ISFM and AAFP consensus guidelines on the long-term use of NSAIDs in cats
JOURNAL OF FELINE MEDICINE AND SURGERY, 26(4).
author keywords: Carprofen; meloxicam; robenacoxib; analgesia; chronic kidney disease; osteoarthritis; degenerative joint disease; pain management; chronic pain
open access via journals.sagepub.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 24, 2024
2024 journal article
Evaluation of the comparative efficacy of green lipped mussel plus krill oil extracts (EAB-277), <i>Biota orientalis</i> extracts or NSAIDs for the treatment of dogs with osteoarthritis associated pain: a blinded, placebo-controlled study
FRONTIERS IN VETERINARY SCIENCE, 11.
author keywords: OA; marine based fatty acid; omega 3; NSAID; gait analysis; PVF
Sources: Web Of Science, NC State University Libraries
Added: November 4, 2024
2024 article
Gut Microbiome and Osteoarthritis: Insights From the Naturally Occurring Canine Model of Osteoarthritis
Stevens, C., Norris, S., Arbeeva, L., Carter, S., Enomoto, M., Nelson, A. E., & Lascelles, B. D. X. (2024, August 9). ARTHRITIS & RHEUMATOLOGY, Vol. 8.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 19, 2024
2024 article
Pharmacokinetics of subcutaneous ketamine administration via the Omnipod® system in dogs
Colon, C., Early, P., Munana, K., Olby, N., Mariani, C., Mancini, S., … Messenger, K. (2024, March 27). JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, Vol. 3.
author keywords: analgesia; canine; ketamine; novel; veterinary
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 8, 2024
2024 journal article
Prevalence of radiographic appendicular osteoarthritis and associated clinical signs in young dogs
SCIENTIFIC REPORTS, 14(1).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 1, 2024
2024 journal article
Response to treatment with grapiprant as part of a standard multimodal regimen in young dogs with appendicular joint osteoarthritis associated pain
FRONTIERS IN VETERINARY SCIENCE, 11.
author keywords: osteoarthritis; pain; dog; grapiprant; force plate; fish oil; exercise
Sources: Web Of Science, NC State University Libraries
Added: November 18, 2024
2024 journal article
Use of Bedinvetmab (Librela®) for Canine Osteoarthritis in France, Germany, Italy, Spain, and the UK: Quantitative Analysis of Veterinarian Satisfaction and Real-World Treatment Patterns
ANIMALS, 14(15).
author keywords: bedinvetmab; Librela; canine osteoarthritis; real-world; pain; canine degenerative joint disease
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 19, 2024
2023 journal article
Activity patterns are associated with fractional lifespan, memory, and gait speed in aged dogs
SCIENTIFIC REPORTS, 13(1).
MeSH headings : Humans; Dogs; Animals; Alzheimer Disease; Longevity; Walking Speed; Gait; Cognition; Cognitive Dysfunction; Aging / psychology; Pain
TL;DR:
It is found that activity patterns in dogs are associated with fractional lifespan and working memory, and dogs with higher on/off leash gait speed are more active in the afternoon of weekdays.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 19, 2023
2023 journal article
Acute radiotherapy-associated oral pain may promote tumor growth at distant sites
FRONTIERS IN ONCOLOGY, 13.
author keywords: pain; radiotherapy; sensory nerves; cancer; mouse; TRPV1
TL;DR:
This research points towards radiation-induced activation of capsaicin-responsive (TRPV1) neurons as the cause for accelerated growth of tumors at distant (unirradiated) sites.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 12, 2023
2023 article
An Exploration of Machine Learning Methods for Gait Analysis of Potential Guide Dogs
TENTH INTERNATIONAL CONFERENCE ON ANIMAL-COMPUTER INTERACTION, ACI 2023.
author keywords: Guide Dog; Canine Behavior Analysis; Canine Gait Analysis; IMU; Machine Learning
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 22, 2024
2023 review
COAST Development Group's international consensus guidelines for the treatment of canine osteoarthritis
[Review of ]. FRONTIERS IN VETERINARY SCIENCE, 10.
author keywords: dog; pain; osteoarthritis; staging; management; treatment guidelines; COASTeR; COAST
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 5, 2023
2023 journal article
Development and validation of a sleep questionnaire, SNoRE 3.0, to evaluate sleep in companion dogs
SCIENTIFIC REPORTS, 13(1).
TL;DR:
A valid and reliable questionnaire tool is described, that can be used as a cost-effective way to monitor dog sleep in clinical settings.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
8. Decent Work and Economic Growth
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 23, 2023
2023 journal article
Minimal clinically-important differences for the 'Liverpool Osteoarthritis in Dogs' (LOAD) and the 'Canine Orthopedic Index' (COI) client-reported outcomes measures
PLOS ONE, 18(2).
TL;DR:
Estimates for MCIDs for these two CROMs are provided which will facilitate sample size estimates in future clinical studies that use theseCROMs as outcomes measures and show that the value of the MCIDs depended on the method that was applied.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 3, 2023
2023 article
Multi-Functional Small Molecule Alleviates Fracture Pain and Promotes Bone Healing
Shih, Y.-R. V., Kingsley, D., Newman, H., Hoque, J., Gupta, A., Lascelles, B. D. X., & Varghese, S. (2023, November 8). ADVANCED SCIENCE, Vol. 11.
author keywords: adenosine; adenosine receptors; biomaterials; drug delivery; fracture healing; fracture pain; phenylboronic acids
TL;DR:
The results demonstrate that local delivery of adenosine inhibited the nociceptive activity of peripheral neurons through activation of adenosine A1 receptor (ADORA1) and mitigated pain as demonstrated by weight bearing and open field movement tests.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 26, 2023
2023 journal article
Nine-axis inertial measurement unit output discriminates activities of varying intensity in the dog
AMERICAN JOURNAL OF VETERINARY RESEARCH, 84(3), 8–8.
MeSH headings : Dogs; Animals; Biomechanical Phenomena; Walking; Acceleration
TL;DR:
The long-range goal is to validate an open-source algorithm for the IMU so activity in a pet's natural environment can be used as an outcome measure in future studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 4, 2023
2023 journal article
Pain sensitivity differs between dog breeds but not in the way veterinarians believe
FRONTIERS IN PAIN RESEARCH, 4.
author keywords: healthcare provider beliefs; attitudes; stereotypes; perceptions of patient pain; canine behavior; quantitative sensory testing; animal welfare; affective states
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 21, 2023
2023 journal article
Study of the effectiveness of glucosamine and chondroitin sulfate, marine based fatty acid compounds (PCSO-524 and EAB-277), and carprofen for the treatment of dogs with hip osteoarthritis: A prospective, block-randomized, double-blinded, placebo-controlled clinical trial
FRONTIERS IN VETERINARY SCIENCE, 10.
author keywords: OA; marine-based fatty acid; non-steroidal anti-inflammatory drug (NSAID); gait analysis; PVF
TL;DR:
PCSO-524 and EAB-277, but not glucosamine/chondroitin, resulted in significant improvements in PVF from baseline after 4 weeks, 6 weeks, and to a similar degree to that seen with carprofen.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 6, 2023
2023 article
Study of the effectiveness of glucosamine and chondroitin sulfate, marine based fatty acid compounds (PCSO-524 and EAB-277), and carprofen for the treatment of dogs with hip osteoarthritis: a prospective, block-randomized, double-blinded, placebo-controlled clinical trial (vol 10, 1033188, 2023)
Kampa, N., Kaenkangploo, D., Jitpean, S., Srithunyarat, T., Seesupa, S., Hoisang, S., … Lascelles, B. D. X. (2023, August 2). FRONTIERS IN VETERINARY SCIENCE, Vol. 10.
author keywords: OA; marine-based fatty acid; non-steroidal anti-inflammatory drug (NSAID); gait analysis; PVF
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 5, 2023
2023 journal article
Veterinary education and experience shape beliefs about dog breeds Part 1: Pain sensitivity
SCIENTIFIC REPORTS, 13(1).
TL;DR:
It is suggested that veterinary education and clinical experiences influence pain sensitivity ratings across dog breeds, and veterinary students rated pain sensitivity across breeds of dog more similarly to veterinary faculty and staff.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 2, 2024
2022 journal article
2022 AAHA Pain Management Guidelines for Dogs and Cats
JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 58(2), 55–76.
MeSH headings : Animals; Cat Diseases / diagnosis; Cat Diseases / drug therapy; Cats; Dog Diseases / drug therapy; Dogs; Pain / drug therapy; Pain / veterinary; Pain Management / veterinary; Pain Measurement / veterinary
TL;DR:
These updated guidelines present a practical and logical approach to the assessment and management of acute and chronic pain in canine and feline patients, and include a tiered decision tree that prioritizes the use of the most efficacious therapeutic modalities for the treatment of chronic pain.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 18, 2022
2022 article
2022 WSAVA guidelines for the recognition, assessment and treatment of pain
Monteiro, B. P., Lascelles, B. D. X., Murrell, J., Robertson, S., Steagall, P. V. M., & Wright, B. (2022, October 27). JOURNAL OF SMALL ANIMAL PRACTICE, Vol. 10.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 7, 2022
2022 journal article
A Pilot, Open-Label Study to Evaluate the Efficacy of Intra-Articular Administration of a Caninized TNF Receptor Fc Fusion Protein as a Treatment for Osteoarthritis-Associated Joint Pain
FRONTIERS IN VETERINARY SCIENCE, 9.
author keywords: osteoarthritis; joint pain; TNF-alpha; force plate; limb use asymmetry test
TL;DR:
The IA injection of caTNFR-Fc fusion protein provided no benefit in terms of objective limb use and activity data in dogs with OA in this pilot study, and data indicate TNF-α may not be a good therapeutic target in canine OA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 27, 2022
2022 journal article
Determination of the center of mass in a heterogeneous population of dogs
PLOS ONE, 17(4).
MeSH headings : Acceleration; Animals; Back; Dogs
TL;DR:
Dog length was the primary variable required to maximize the relationship between three-dimensional CoM and identifiable variables measured, and a CoM based normalization procedure should be considered to normalize mass or motion based outcome measure output in a heterogeneous population of dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 29, 2022
2022 article
Identification of canine osteoarthritis using an owner-reported questionnaire and treatment monitoring using functional mobility tests
Wright, A., Amodie, D. M., Cernicchiaro, N., Lascelles, B. D. X., Pavlock, A. M., Roberts, C., & Bartram, D. J. (2022, April 6). JOURNAL OF SMALL ANIMAL PRACTICE, Vol. 4.
MeSH headings : Animals; Chronic Pain / veterinary; Dog Diseases / diagnosis; Dog Diseases / drug therapy; Dogs; Osteoarthritis / diagnosis; Osteoarthritis / drug therapy; Osteoarthritis / veterinary; Pain Measurement / veterinary; Surveys and Questionnaires
TL;DR:
More osteoarthritis cases were identified in study dogs than previous prevalence estimates, indicating the screening checklist's potential to help identify for further evaluation cases that could otherwise remain undiagnosed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 25, 2022
2022 journal article
Initial exploration of the discriminatory ability of the PetPace collar to detect differences in activity and physiological variables between healthy and osteoarthritic dogs
FRONTIERS IN PAIN RESEARCH, 3.
Contributors: J. Robertson n
author keywords: canine; physical activity monitor; osteoarthritis; mobility; pain; accelerometry
TL;DR:
The results of this study suggest that the PetPace collar can detect differences between healthy dogs and those with OA-pain, and that Oa-pain negatively impacts overall activity levels in dogs, and especially higher intensity activity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 7, 2022
2022 article
Intensity of perioperative analgesia but not pre-treatment pain is predictive of survival in dogs undergoing amputation plus chemotherapy for extremity osteosarcoma
Nolan, M. W., Uzan, O. C., Green, N. A., Lana, S. E., & Lascelles, B. D. X. (2022, March 21). VETERINARY AND COMPARATIVE ONCOLOGY, Vol. 3.
author keywords: analgesia; cancer pain; cancer treatment pain; local anaesthesia; malignant osteolysis
MeSH headings : Amputation, Surgical / veterinary; Analgesia / veterinary; Animals; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Bone Neoplasms / drug therapy; Bone Neoplasms / surgery; Bone Neoplasms / veterinary; Dog Diseases / drug therapy; Dog Diseases / surgery; Dogs; Extremities / surgery; Osteosarcoma / drug therapy; Osteosarcoma / surgery; Osteosarcoma / veterinary; Pain / drug therapy; Pain / veterinary; Retrospective Studies; Treatment Outcome
TL;DR:
In dogs treated with limb amputation and adjunctive chemotherapy for osteosarcoma, oncologic outcomes are impacted by either baseline cancer pain severity, or the approaches used for perioperative pain management.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 4, 2022
2022 journal article
Investigating the Role of Artemin and Its Cognate Receptor, GFR alpha 3, in Osteoarthritis Pain
FRONTIERS IN NEUROSCIENCE, 16.
author keywords: pain; osteoarthritis (OA); artemin; GFR alpha 3; TRPV1; monoiodoacetate (MIA)
TL;DR:
The results provide a molecular basis of arthritis pain linked with artemin/GFRα3 signaling and indicate that further work is warranted to investigate the neuronal plasticity and the pathways that drive pain in OA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 28, 2022
2022 article
Long-term follow up of 44 cats undergoing total hip replacement: Cases from a feline hip registry (2010-2020)
Tilve, V. R., Allaith, S., Girling, S., Moores, A. P., Mulholland, L., Morrison, S., … Comerford, E. (2022, June 1). VETERINARY SURGERY, Vol. 6.
MeSH headings : Animals; Arthroplasty, Replacement, Hip / adverse effects; Arthroplasty, Replacement, Hip / veterinary; Cats / surgery; Follow-Up Studies; Hip Prosthesis / veterinary; Humans; Male; Registries; Retrospective Studies; Treatment Outcome
TL;DR:
A validated client metrology questionnaire showed clinical improvement in cats following THR, and total hip replacement appears to be a successful surgical treatment for feline hip disease with very good owner satisfaction and acceptable complication rates.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 13, 2022
2022 journal article
Pilot comparison of outcome measures across chemical and surgical experimental models of chronic osteoarthritis in the rat (Rattus norvegicus)
PLOS ONE, 17(11).
Ed(s): A. Wijnen
MeSH headings : Rats; Animals; Rats, Sprague-Dawley; Lameness, Animal; Disease Models, Animal; Osteoarthritis / complications; Pain / complications; Models, Anatomic; Outcome Assessment, Health Care
TL;DR:
The pilot data suggest both the ACL+DMM and MIA models are equal in terms of clinically relevant pain behaviors, but the MIA model is associated with more severe histological changes over time potentially making it more suitable for screening disease modifying agents.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 22, 2022
2022 article
Spatial and Temporal Analytic Pipeline for Evaluation of Potential Guide Dogs Using Location and Behavior Data
NINTH INTERNATIONAL CONFERENCE ON ANIMAL-COMPUTER INTERACTION, ACI 2022.
author keywords: Guide Dog; Canine Behavior Analysis; Feature Extraction; IMU; Machine Learning; Clustering
TL;DR:
A preliminary data analysis workflow is demonstrated that is able to provide detailed information about candidate guide dogs’ day to day physical exercise levels and gait activities using objective environmental and behavioral data collected from a wearable collar-based Internet of Things device.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 30, 2023
2022 journal article
Static posturography as a novel measure of the effects of aging on postural control in dogs
PLOS ONE, 17(7).
Ed(s): R. Evans
MeSH headings : Acceleration; Aging; Animals; Arthralgia; Dogs; Postural Balance; Reproducibility of Results
TL;DR:
It is found that pressure sensitive walkway systems are a reliable tool to evaluate postural sway in dogs; and that postural swayed is affected by morphometric parameters and increases with age and joint pain.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 12, 2022
2021 journal article
Assessment of Sensory Thresholds in Dogs using Mechanical and Hot Thermal Quantitative Sensory Testing
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 10(176).
MeSH headings : Animals; Dogs; Hot Temperature; Humans; Osteoarthritis; Pain; Pain Measurement / methods; Pain Threshold / physiology; Reproducibility of Results; Sensory Thresholds / physiology
TL;DR:
The QST operator and handler should be familiar and comfortable with handling dogs and interpreting dogs' behavioral responses to potentially painful stimuli to determine the endpoint of testing, reduce stress, and maintain safety during the testing process.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 15, 2021
2021 journal article
Behavioral phenotyping of cancer pain in domesticated cats with naturally occurring squamous cell carcinoma of the tongue: initial validation studies provide evidence for regional and widespread algoplasticity
PEERJ, 9.
author keywords: Comparative oncology; Comparative pain research; Animal models; Translational research; Feline
TL;DR:
Based on preliminary assessments, the assays described herein had reasonable inter-rater reliability, and they were able to both discriminate between cats with and without oral cancer, and respond in a predictable manner to analgesic therapy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 30, 2021
2021 journal article
Biological resurfacing in a canine model of hip osteoarthritis
SCIENCE ADVANCES, 7(38).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 16, 2021
2021 article
Clinical safety of robenacoxib in cats with chronic musculoskeletal disease
King, J. N., Seewald, W., Forster, S., Friton, G., Adrian, D. E., & Lascelles, B. D. X. (2021, July 1). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 7.
author keywords: adverse event; coxib; harm; NSAID
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / adverse effects; Cat Diseases / drug therapy; Cats; Diphenylamine / adverse effects; Diphenylamine / analogs & derivatives; Musculoskeletal Diseases / drug therapy; Musculoskeletal Diseases / veterinary; Phenylacetates; Prospective Studies
TL;DR:
Robenacoxib was not associated with increased risk of AEs compared to placebo when administered for 4 to 12 weeks to cats with CMSD and generalizability of the results to general practice is limited by the fact that cases with severe and uncontrolled concomitant diseases were not included.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: July 12, 2021
2021 article
Defining the rate of, and factors influencing, radiographic progression of osteoarthritis of the canine hip joint
Enomoto, M., Baines, E. A., Roe, S. C., Marcellin-Little, D. J., & Lascelles, B. D. X. (2021, June 12). VETERINARY RECORD, Vol. 6.
MeSH headings : Animals; Arthroplasty, Replacement, Hip / veterinary; Dog Diseases / diagnostic imaging; Dog Diseases / surgery; Dogs; Female; Hip Joint / diagnostic imaging; Hip Joint / surgery; Osteoarthritis, Hip / diagnostic imaging; Osteoarthritis, Hip / surgery; Osteoarthritis, Hip / veterinary; Radiography
TL;DR:
The rate of progression of radiographically assessed coxofemoral OA varies greatly, but is faster in younger, spayed female dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 16, 2021
2021 article
Evaluation of a nutritional supplement for the alleviation of pain associated with feline degenerative joint disease: a prospective, randomized, stratified, double-blind, placebo-controlled clinical trial
Cunningham, R., Gruen, M. E., Thomson, A., & Lascelles, B. D. X. (2021, November 1). JOURNAL OF FELINE MEDICINE AND SURGERY, Vol. 11.
author keywords: Glucosamine hydrochloride; chondroitin sulfate; nutritional supplement; mobility; accelerometer; activity
MeSH headings : Animals; Cat Diseases / drug therapy; Cats; Chondroitin Sulfates / therapeutic use; Double-Blind Method; Glucosamine / therapeutic use; Joint Diseases / veterinary; Musculoskeletal Pain / drug therapy; Musculoskeletal Pain / veterinary; Prospective Studies; Quality of Life; Treatment Outcome
TL;DR:
This study showed a strong placebo effect and the glucosamine/chondroitin sulfate supplement did not show pain-relieving effects when compared with placebo, and no differences in activity were seen between the groups.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 2, 2021
2021 article
Frunevetmab, a felinized anti-nerve growth factor monoclonal antibody, for the treatment of pain from osteoarthritis in cats
Gruen, M. E., Myers, J. A. E., Tena, J.-K. S., Becskei, C., Cleaver, D. M., & Lascelles, B. D. X. (2021, November 1). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 11.
author keywords: arthritis; client specific outcome measures; CSOM; degenerative joint disease; feline; feline musculoskeletal pain index; FMPI
MeSH headings : Animals; Antibodies, Monoclonal / therapeutic use; Cat Diseases / drug therapy; Cats; Double-Blind Method; Osteoarthritis / drug therapy; Osteoarthritis / veterinary; Pain / veterinary; Surveys and Questionnaires; Treatment Outcome
TL;DR:
Frunevetmab has the potential to address a critical gap in the treatment of pain because of osteoarthritis in cats and has been evaluated in a randomized, placebo‐controlled, parallel‐group, double‐blind superiority study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 2, 2021
2021 review
Injectable Capsaicin for the Management of Pain Due to Osteoarthritis
[Review of ]. MOLECULES, 26(4).
author keywords: intra-articular; cooling; knee; defunctionalization; nociceptive fiber; TRPV1; primary afferent; nociceptor; disruption
MeSH headings : Animals; Capsaicin / therapeutic use; Humans; Neuralgia / drug therapy; Neuralgia / metabolism; Neuralgia / pathology; Nociceptors / metabolism; Nociceptors / pathology; Osteoarthritis / drug therapy; Osteoarthritis / metabolism; Osteoarthritis / pathology; TRPV Cation Channels / antagonists & inhibitors; TRPV Cation Channels / metabolism
TL;DR:
This review focuses on the rationale for using capsaicin by injection for painful conditions such as osteoarthritis and provides an update on studies completed to date.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 8, 2021
2021 journal article
Irradiation of the Normal Murine Tongue Causes Upregulation and Activation of Transient Receptor Potential (TRP) Ion Channels
RADIATION RESEARCH, 196(4), 331–344.
MeSH headings : Animals; Calcium; Female; Mice; Neurons; Transient Receptor Potential Channels; Trigeminal Ganglion; Up-Regulation
TL;DR:
The results intimate that various TRP channels, and TRPV1 in particular, should be explored as analgesic targets for patients experiencing pain after oral irradiation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 18, 2021
2021 journal article
Novel approach to modeling high-frequency activity data to assess therapeutic effects of analgesics in chronic pain conditions
SCIENTIFIC REPORTS, 11(1).
MeSH headings : Analgesics / therapeutic use; Animals; Cat Diseases / drug therapy; Cats; Chronic Pain / drug therapy; Chronic Pain / veterinary; Cross-Over Studies; Double-Blind Method; Markov Chains; Models, Theoretical; Placebos; Poisson Distribution
TL;DR:
A zero inflated Poisson hidden semi-Markov model is used to characterize activity patterns and derive estimators of the treatment effect in terms of changes in activity levels or frequency of activity type using data from a naturally occurring feline OA-associated pain model.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 10, 2021
2021 article
Refinement of the Feline Musculoskeletal Pain Index (FMPI) and development of the short-form FMPI
Enomoto, M., Lascelles, B. D. X., Robertson, J. B., & Gruen, M. E. (2021, May 18). JOURNAL OF FELINE MEDICINE AND SURGERY, Vol. 5.
author keywords: Osteoarthritis; pain; musculoskeletal disease; degenerative joint disease; behavioral change; outcome measure
MeSH headings : Analgesics; Animals; Cat Diseases / diagnosis; Cat Diseases / drug therapy; Cats; Musculoskeletal Pain / veterinary; Reproducibility of Results; Surveys and Questionnaires
TL;DR:
The proposed FMPI-sf may be able to better distinguish between placebo and analgesic effects in cats with DJD and its reliability was reassessed using the data sets described above.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: May 19, 2021
2021 journal article
Robenacoxib shows efficacy for the treatment of chronic degenerative joint disease-associated pain in cats: a randomized and blinded pilot clinical trial
Scientific Reports Volume, 11(1), 7721.
MeSH headings : Animals; Cat Diseases / drug therapy; Cats; Diphenylamine / analogs & derivatives; Diphenylamine / therapeutic use; Female; Joint Diseases / complications; Joint Diseases / veterinary; Male; Osteoarthritis / complications; Osteoarthritis / veterinary; Pain / complications; Pain / veterinary; Pain Management / veterinary; Phenylacetates / therapeutic use; Pilot Projects; Placebos
TL;DR:
Results identified suitable endpoints for confirmatory studies, while also indicating efficacy of robenacoxib in cats with DJD-pain, and decreased owner-assessed disability.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 18, 2021
2021 journal article
Serum artemin is not correlated with sensitivity within dogs with naturally occurring osteoarthritis pain
SCIENTIFIC REPORTS, 11(1).
MeSH headings : Animals; Arthralgia / diagnosis; Arthralgia / etiology; Dogs; Female; Male; Nerve Tissue Proteins / blood; Osteoarthritis / blood; Osteoarthritis / complications; Pain Threshold; Severity of Illness Index; Symptom Assessment
TL;DR:
Serum ARTN was not associated with the degree of sensitization within dogs with OAP, and across dogs with varying OAP severity, there did not find any association between ARTN, and clinical measures of joint pain and disability, although a relationship between Artemin and joint pain was not ruled out.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 19, 2021
2020 journal article
A functional linear modeling approach to sleep-wake cycles in dogs
SCIENTIFIC REPORTS, 10(1).
MeSH headings : Algorithms; Animals; Behavior, Animal; Dogs; Models, Biological; Sleep / physiology; Wakefulness / physiology
TL;DR:
It is demonstrated that FLM can be used to describe normal sleep–wake cycles of healthy adult dogs and the effects of physiologic traits on these patterns of activity, and makes it possible to characterize deviations from normal patterns, including those associated with chronic pain and cognitive dysfunction syndrome.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 25, 2021
2020 journal article
Atenolol in cats with subclinical hypertrophic cardiomyopathy: a double-blind, placebo-controlled, randomized clinical trial of effect on quality of life, activity, and cardiac biomarkers
JOURNAL OF VETERINARY CARDIOLOGY, 30, 77–91.
author keywords: Feline; Beta-btocker; Accelerometry
MeSH headings : Administration, Oral; Animals; Anti-Arrhythmia Agents / administration & dosage; Anti-Arrhythmia Agents / therapeutic use; Atenolol / administration & dosage; Atenolol / therapeutic use; Biomarkers / blood; Cardiomyopathy, Hypertrophic / drug therapy; Cardiomyopathy, Hypertrophic / veterinary; Cat Diseases / blood; Cat Diseases / drug therapy; Cats; Double-Blind Method; Female; Male; Quality of Life; Treatment Outcome
TL;DR:
This study failed to identify an effect of subclinical HCM on owner-assessed QOL or activity or a treatment effect of atenolol on these variables at the dosage evaluated, and these findings do not support a treatment benefit of atanolol for the goal of symptom reduction in cats with sub clinical HCM.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 21, 2020
2020 review
Early Neonatal Pain-A Review of Clinical and Experimental Implications on Painful Conditions Later in Life
[Review of ]. FRONTIERS IN PEDIATRICS, 8.
author keywords: neonatal pain; early life; consequences; neurobiology; mechanisms; animal models; chronic pain
TL;DR:
A narrative review of the literature pertaining to the idea that early life pain has significant long-term effects on neurosensory, cognition, behavior, pain processing, and health outcomes that persist into childhood and even adulthood is provided.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: March 23, 2020
2020 journal article
Early radiation‐induced oral pain signaling responses are reduced with pentoxifylline treatment
Veterinary Radiology & Ultrasound, 62(2), 255–263.
author keywords: glossitis; mucositis; TNF‐ α TRPV1; TRPV4
MeSH headings : Animals; Capsaicin / pharmacology; Histamine / pharmacology; Mice; Pain / prevention & control; Pain / veterinary; Pentoxifylline / therapeutic use; Pilot Projects; Prospective Studies; Radiation-Protective Agents / therapeutic use; Radiotherapy / adverse effects; Sensory System Agents / pharmacology; Signal Transduction / drug effects; Stomatitis / complications; Stomatitis / drug therapy; Stomatitis / etiology; Tumor Necrosis Factor-alpha / analysis; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
Although PTX treatment did not reduce glossitis severity or mitigate weight loss in mice with RIM/RAP, it did inhibit the upregulation of TNF-α's receptor that normally accompanies RIM, and it also reduced neuronal responsiveness to each of the aforementioned chemical stimuli.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: January 11, 2021
2020 journal article
Glaucoma-associated pain results in mechanical sensitivity changes in dogs: A pilot study
VETERINARY OPHTHALMOLOGY, 24, 116–124.
author keywords: canine; central sensitization; chronic glaucoma; corneal esthesiometry; ocular pain; quantitative sensory testing
MeSH headings : Animals; Chronic Disease / veterinary; Dog Diseases / physiopathology; Dog Diseases / surgery; Dogs; Eye Enucleation / veterinary; Female; Glaucoma / complications; Glaucoma / surgery; Glaucoma / veterinary; Male; Pain / etiology; Pain / veterinary; Pain Measurement / veterinary; Pain Threshold; Physical Stimulation; Pilot Projects; Prospective Studies; Sensory Thresholds
TL;DR:
Sensitivity to mechanical stimuli decreased both locally and at remote sites in dogs following enucleation for painful chronic glaucoma and Cranial conformation is associated with differences in sensitivity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 27, 2020
2020 review
Ice therapy: cool, current and complicated
[Review of ]. JOURNAL OF SMALL ANIMAL PRACTICE, 61(5), 267–271.
MeSH headings : Animals; Cryotherapy / veterinary; Ice; Pain / veterinary; Pain Management / veterinary
TL;DR:
The physiological effects of cold therapy on tissues, receptors and ion channels are discussed; as well as indications, recommendations for, and limitations of use.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 27, 2020
2020 journal article
Impact of radiation dose and pre-treatment pain levels on survival in dogs undergoing radiotherapy with or without chemotherapy for presumed extremity osteosarcoma
VETERINARY AND COMPARATIVE ONCOLOGY, 18(4), 538–547.
author keywords: analgesia; appendicular bone tumour; malignant osteolysis; palliative; primary bone tumour; radiosurgery
MeSH headings : Animals; Antineoplastic Agents / therapeutic use; Bone Neoplasms / drug therapy; Bone Neoplasms / mortality; Bone Neoplasms / radiotherapy; Bone Neoplasms / veterinary; Dog Diseases / drug therapy; Dog Diseases / mortality; Dog Diseases / radiotherapy; Dogs; Female; Fractures, Bone / complications; Fractures, Bone / veterinary; Lung Neoplasms / radiotherapy; Lung Neoplasms / secondary; Male; North Carolina / epidemiology; Osteosarcoma / drug therapy; Osteosarcoma / mortality; Osteosarcoma / radiotherapy; Osteosarcoma / veterinary; Pain / veterinary; Radiation Dosage; Radiotherapy / methods; Radiotherapy / veterinary; Retrospective Studies; Survival
TL;DR:
In a univariate analysis, dogs with pulmonary metastases and high pain at the time of irradiation had short overall survival times; use of high radiation doses and chemotherapy were associated with improved survival.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 10, 2020
2020 journal article
Local Administration of Carboplatin in Poloxamer 407 After an Ulnar Osteosarcoma Removal in a Dog
JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 56(6), 325–330.
MeSH headings : Amputation, Surgical / veterinary; Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / therapeutic use; Bone Neoplasms / therapy; Bone Neoplasms / veterinary; Carboplatin / administration & dosage; Carboplatin / therapeutic use; Dog Diseases / drug therapy; Dogs; Forelimb / pathology; Forelimb / surgery; Male; Neoplasm Recurrence, Local / surgery; Neoplasm Recurrence, Local / veterinary; Osteosarcoma / therapy; Osteosarcoma / veterinary; Poloxamer / chemistry
TL;DR:
This is the first report in the veterinary literature of using poloxamer 407 as a carrier for local delivery of chemotherapeutic drugs in a clinical patient.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 22, 2021
2020 journal article
Protease activated receptor 2 and matriptase expression in the joints of cats with and without osteoarthritis
JOURNAL OF FELINE MEDICINE AND SURGERY, 23(8), 794–803.
author keywords: PAR2; matriptase; osteoarthritis; cartilage; synovium
MeSH headings : Animals; Cartilage, Articular; Cat Diseases; Cats; Chondrocytes; Osteoarthritis / veterinary; Receptor, PAR-2; Serine Endopeptidases
TL;DR:
D detection of PAR2 and matriptase proteins and gene expression in feline articular tissues is a novel and important finding, and supports the hypothesis that serine proteases are involved in the pathogenesis of feline OA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 19, 2021
2020 article
The effectiveness of marine based fatty acid compound (PCSO-524) and firocoxib in the treatment of canine osteoarthritis (vol 15, 349, 2019)
Vijarnsorn, M., Kwananocha, I., Kashemsant, N., Jarudecha, T., Lekcharoensuk, C., Beale, B., … Lascelles, B. D. X. (2020, December 16). BMC VETERINARY RESEARCH, Vol. 16.
TL;DR:
An amendment to this paper has been published and can be accessed via the original article.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 4, 2021
2019 journal article
Clinical measurements performed during alfaxalone total intravenous anaesthesia for radiography and neurophysiological investigations in dogs
VETERINARY ANAESTHESIA AND ANALGESIA, 46(4), 483–487.
author keywords: alfaxalone; dog; total intravenous anaesthesia
MeSH headings : Anesthesia, Intravenous / veterinary; Anesthetics / administration & dosage; Anesthetics / adverse effects; Anesthetics / pharmacology; Animals; Apnea / chemically induced; Apnea / veterinary; Blood Glucose; Blood Pressure / drug effects; Carbon Dioxide / blood; Case-Control Studies; Dog Diseases / diagnostic imaging; Dogs; Female; Heart Rate / drug effects; Male; Osteoarthritis / diagnostic imaging; Osteoarthritis / veterinary; Oxygen / blood; Pregnanediones / administration & dosage; Pregnanediones / adverse effects; Pregnanediones / pharmacology; Radiography / veterinary; Respiration / drug effects
TL;DR:
Alfaxalone infusion provided effective anaesthesia in this population of middle-aged or older dogs and in a minority of cases, respiratory and haemodynamic support of the patient was required.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: July 15, 2019
2019 journal article
Evaluation and comparison of pain questionnaires for clinical screening of osteoarthritis in cats
VETERINARY RECORD, 185(24).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: February 17, 2020
2019 review
Intraperitoneal and incisional analgesia in small animals: simple, cost-effective techniques
[Review of ]. JOURNAL OF SMALL ANIMAL PRACTICE, 61(1), 19–23.
MeSH headings : Analgesia / veterinary; Animals; Cost-Benefit Analysis; Pain / veterinary; Pain Management / veterinary
TL;DR:
The World Small Animal Veterinary Association Global Pain Council (WSAVA-GPC) has recently published its first "capsule review" by Monteiro et al, where the use of intraperitoneal and incisional analgesia in small animal practice is discussed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: December 2, 2019
2019 journal article
Itch-associated Neuropeptides and Their Receptor Expression in Dog Dorsal Root Ganglia and Spinal Cord
ACTA DERMATO-VENEREOLOGICA, 99(12), 1131–1135.
Contributors: J. Wheeler*, B. Lascelles n, T. Olivry n & S. Mishra*
author keywords: dog; canine atopic dermatitis; somatostatin; NPPB; NMB; GRP
MeSH headings : Animals; Calcium Signaling; Cells, Cultured; Dogs; Female; Ganglia, Spinal / metabolism; Ganglia, Spinal / physiopathology; Gene Expression Regulation; Male; Neuropeptides / genetics; Neuropeptides / metabolism; Pruritus / genetics; Pruritus / metabolism; Pruritus / physiopathology; Receptors, Neuropeptide / genetics; Receptors, Neuropeptide / metabolism; Spinal Cord / metabolism; Spinal Cord / physiopathology
TL;DR:
The results provide the first evidence that dogs use similar pruritogenic pathways to those characterized in mice and thus identify multiple targets for the future treatment of itch in dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: December 2, 2019
2019 review
Long-term use of non-steroidal anti-inflammatory drugs in cats with chronic kidney disease: from controversy to optimism
[Review of ]. JOURNAL OF SMALL ANIMAL PRACTICE, 60(8), 459–462.
MeSH headings : Analgesics / therapeutic use; Animals; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Cat Diseases; Cats; Pain / veterinary; Renal Insufficiency, Chronic / veterinary
TL;DR:
The scientific evidence available on the long-term use of non-steroidal anti-inflammatory drugs in cats with concomitant chronic pain and chronic kidney disease is discussed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 12, 2019
2019 review
Measurement of chronic pain in companion animals: Discussions from the Pain in Animals Workshop (PAW) 2017
[Review of ]. VETERINARY JOURNAL, 250, 71–78.
author keywords: Cat; Chronic; Dog; Measurement; Pain
MeSH headings : Animals; Cat Diseases / pathology; Cats; Chronic Pain / pathology; Chronic Pain / veterinary; Dog Diseases / pathology; Dogs; Pain Measurement / veterinary
TL;DR:
There is a considerable interest in improving the assessment of chronic pain, as evidenced by the multiple disciplines across industry, academia, and clinical practice from the veterinary and human medical fields that participated in the Pain in Animals Workshop held at the National Institutes of Health in 2017.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: September 16, 2019
2019 review
Measurement of chronic pain in companion animals: Priorities for future research and development based on discussions from the Pain in Animals Workshop (PAW) 2017
[Review of ]. VETERINARY JOURNAL, 252.
author keywords: Cat; Chronic; Dog; Measurement; Pain; Research priorities
MeSH headings : Animals; Cats; Chronic Pain / diagnosis; Chronic Pain / veterinary; Dogs; Pain Management / veterinary; Research Design / trends; Veterinary Medicine / trends
TL;DR:
The estimation of long-standing pain in companion animals through the measurement of different dimensions impacted by pain is a fundamental requirement if pain management, and pain therapeutic development, are to advance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 15, 2020
2019 journal article
The effectiveness of marine based fatty acid compound (PCSO-524) and firocoxib in the treatment of canine osteoarthritis
BMC VETERINARY RESEARCH, 15(1).
author keywords: Osteoarthritis; Treatment; PCSO-524; NSAIDs; Firocoxib; Gait analysis; Dog
MeSH headings : 4-Butyrolactone / analogs & derivatives; 4-Butyrolactone / therapeutic use; Animals; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Dinoprostone / blood; Dog Diseases / drug therapy; Dogs; Double-Blind Method; Drug Therapy, Combination; Fatty Acids, Unsaturated / therapeutic use; Female; Gait / drug effects; Male; Osteoarthritis / complications; Osteoarthritis / drug therapy; Osteoarthritis / veterinary; Pain / drug therapy; Pain / etiology; Pain / veterinary; Pain Measurement / veterinary; Prospective Studies; Sulfones / therapeutic use
TL;DR:
Combined use of both PCSO-524 and firocoxib is suggested to be more effective in alleviation of inflammation and improvement of weight bearing ability when compared to the uses of either PCso-524 or firo Coxib alone.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 4, 2019
2018 journal article
Anti-nerve growth factor monoclonal antibodies for the control of pain in dogs and cats
Vet Rec, 184(1), 14.
MeSH headings : Animals; Antibodies, Monoclonal / therapeutic use; Cat Diseases / therapy; Cats; Dog Diseases / therapy; Dogs; Nerve Growth Factors / antagonists & inhibitors; Osteoarthritis / complications; Osteoarthritis / therapy; Osteoarthritis / veterinary; Pain / etiology; Pain / veterinary; Pain Management / veterinary; Randomized Controlled Trials as Topic
TL;DR:
The mechanism of action of NGF, the role of N GF in osteoarthritis, research in rodent OA models and the current status of the development of anti-NGF mAbs in humans are outlined.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 25, 2019
2018 journal article
Assessment of a novel nanoparticle hyperthermia therapy in a murine model of osteosarcoma
Vet Surg, 47(8), 1021–1030.
MeSH headings : Animals; Bone Neoplasms / therapy; Bone Neoplasms / veterinary; Disease Models, Animal; Dog Diseases / blood; Dog Diseases / therapy; Dogs; Female; Hyperthermia, Induced / veterinary; Mice; Mice, Inbred C3H; Monocytes / physiology; Nanoparticles; Osteosarcoma / therapy; Osteosarcoma / veterinary; Phenotype; Receptors, CXCR4 / genetics
TL;DR:
Enhancing monocyte/macrophage function in dogs with OS may enhance antitumor immunity and Nanoparticle hyperthermia therapy increased in vitro monocyte chemotaxis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 25, 2019
2018 journal article
Characterization of gene expression in naturally occurring feline degenerative joint disease-associated pain
The Veterinary Journal, 243, 42–47.
author keywords: Cat; Degenerative joint disease; Neurobiological signature; Osteoarthritis; Pain
MeSH headings : Animals; Cat Diseases / genetics; Cats; Female; Ganglia, Spinal / metabolism; Ganglia, Spinal / physiopathology; Gene Expression; Gene Expression Profiling; Lumbosacral Region / physiopathology; Male; Osteoarthritis, Spine / veterinary; Pain / genetics; Pain / veterinary; Spinal Cord Dorsal Horn / metabolism; Spinal Cord Dorsal Horn / physiopathology
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: February 11, 2019
2018 journal article
Clinical safety of robenacoxib (Onsior (TM)) in cats with chronic musculo-skeletal disorder or osteoarthritis
Journal of Veterinary Pharmacology and Therapeutics, 41, 159–160.
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
Content validation of a critical appraisal tool for reviewing analgesia studies (CATRAS) involving subjects incapable of self-reporting pain
Pain Rep, 3(4).
author keywords: Critical appraisal tool; Analgesia; Pain
TL;DR:
This 67-item critical appraisal tool may enable critical and quantitative assessment of the quality of individual analgesia trials involving subjects incapable of self-reporting pain for use in systematic reviews and meta-analysis studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 25, 2019
2018 journal article
Effect of sucralfate on gastric permeability in an ex vivo model of stress-related mucosal disease in dogs
Journal of Veterinary Internal Medicine, 32(2), 670–678.
author keywords: barrier function; stress ulcer; transepithelial electrical resistance; Ussing chamber
MeSH headings : Animals; Anti-Ulcer Agents / administration & dosage; Anti-Ulcer Agents / pharmacology; Dog Diseases / chemically induced; Dog Diseases / drug therapy; Dog Diseases / prevention & control; Dogs; Gastric Mucosa / drug effects; Gastric Mucosa / pathology; Hydrogen-Ion Concentration; In Vitro Techniques; Isotonic Solutions; Ringer's Solution; Stomach Ulcer / chemically induced; Stomach Ulcer / drug therapy; Stomach Ulcer / prevention & control; Stomach Ulcer / veterinary; Sucralfate / administration & dosage; Sucralfate / pharmacology
TL;DR:
Sorbitfate appeared effective at restoring defects in gastric barrier function induced by acid and accelerating repair of tissues subjected to acid in this model, suggesting that sucralfate could have utility for the treatment and prevention of SRMD in dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2018 journal article
Electrophysiological characterisation of central sensitisation in canine spontaneous osteoarthritis
PAIN, 159(11), 2318–2330.
author keywords: Central sensitisation; Diffuse noxious inhibitory controls; Dog; Nociceptive withdrawal reflex; Osteoarthritis
MeSH headings : Acepromazine / pharmacology; Animals; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Case-Control Studies; Central Nervous System Sensitization / drug effects; Central Nervous System Sensitization / physiology; Dogs; Dopamine Antagonists / pharmacology; Electromyography; Electrophysiological Phenomena / physiology; Evoked Potentials, Motor / drug effects; Evoked Potentials, Motor / physiology; Musculoskeletal Abnormalities / diagnosis; Musculoskeletal Abnormalities / etiology; Osteoarthritis / drug therapy; Osteoarthritis / physiopathology; Osteoarthritis / veterinary; Pain Threshold / drug effects; Pain Threshold / physiology; Reflex / drug effects; X-Rays
TL;DR:
Evidence of neurophysiological changes consistent with CS is provided in dogs with spontaneous OA and it is demonstrated that canine OA is associated with reduced DNIC.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 10, 2018
2018 journal article
Enrichment Preferences of FIV-Infected and Uninfected Laboratory-Housed Cats
Viruses, 10(7), 353.
author keywords: FIV; enrichment; welfare; feline; laboratory animal
MeSH headings : Animals; Animals, Laboratory; Cats; Feline Acquired Immunodeficiency Syndrome / virology; Immunodeficiency Virus, Feline / physiology
TL;DR:
Cats used in a longitudinal study of the effects of chronic feline immunodeficiency virus (FIV) infection were used and it was found that cats elected to be brushed, preferred social interaction and play with the laser to the ball, and preferred to scratch on an inclined-box toenail conditioning object compared to a horizontal, circular toenails conditioning object.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: October 16, 2018
2018 journal article
Evaluation of the effect of signalment and owner-reported impairment level on accelerometer-measured changes in activity in osteoarthritic dogs receiving a non-steroidal anti-inflammatory
VETERINARY JOURNAL, 242, 48–52.
author keywords: Accelerometer; Activity; Osteoarthritis; Non-steroidal anti-inflammatory; Pain
MeSH headings : Accelerometry / veterinary; Animals; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Chronic Pain / drug therapy; Chronic Pain / veterinary; Dog Diseases / drug therapy; Dog Diseases / physiopathology; Dogs; Female; Humans; Male; Osteoarthritis, Hip / drug therapy; Osteoarthritis, Hip / physiopathology; Osteoarthritis, Hip / veterinary; Pain Measurement / veterinary; Prospective Studies
TL;DR:
Evaluated the effect of signalment and initial impairment level on accelerometer-measured changes in activity in osteoarthritic dogs after receiving a non-steroidal anti-inflammatory (NSAID) treatment and found greater initial impairment was associated with larger positive changes inActivity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 31, 2018
2018 article
Face validity of a proposed tool for staging canine osteoarthritis: Canine OsteoArthritis Staging Tool (COAST)
Cachon, T., Frykman, O., Innes, J. F., Lascelles, B. D. X., Okumura, M., Sousa, P., … Van Ryssen, B. (2018, May). VETERINARY JOURNAL, Vol. 235, pp. 1–8.
MeSH headings : Animals; Behavior, Animal / physiology; Dog Diseases / diagnosis; Dog Diseases / pathology; Dog Diseases / physiopathology; Dogs; Genetic Predisposition to Disease; Orthopedics / methods; Orthopedics / veterinary; Osteoarthritis / pathology; Osteoarthritis / physiopathology; Osteoarthritis / veterinary; Pain / diagnosis; Pain / veterinary; Reproducibility of Results
TL;DR:
This paper presents a meta-analyses of the immune system’s response to chronic pain and its role in the development of central nervous system disorders.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2018 journal article
Face validity of a proposed tool for staging canine osteoarthritis: Canine OsteoArthritis Staging Tool (COAST)
Veterinary Journal (London, England: 1997), 235, 1–8.
Source: ORCID
Added: January 22, 2019
2018 journal article
Influence of gait on bone strength in turkeys with leg defects
Poult Sci, 97(8), 2621–2637.
author keywords: gait parameter; bone strength; turkey; leg defect; welfare; locomotion; BMD
MeSH headings : Animals; Biomechanical Phenomena; Bone Density; Gait; Hindlimb / abnormalities; Kinetics; Male; Tarsus, Animal; Turkeys / abnormalities; Turkeys / growth & development; Turkeys / physiology
TL;DR:
Only crooked toes caused consistent differences in gait patterns, bone properties and bone strength, but in general, gait kinetics was correlated with bone biomechanics in turkeys.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: January 25, 2019
2018 journal article
Initial evaluation of PetPace activity monitor
Vet J, 237, 63–68.
author keywords: Activity; Accelerometer; Dog; Monitor; Osteoarthritis
MeSH headings : Accelerometry / instrumentation; Accelerometry / methods; Accelerometry / standards; Accelerometry / veterinary; Actigraphy / instrumentation; Actigraphy / methods; Actigraphy / standards; Actigraphy / veterinary; Animals; Back; Dogs / physiology; Humans; Monitoring, Physiologic / methods; Monitoring, Physiologic / veterinary; Motor Activity / physiology; Quality of Life; Veterinarians
TL;DR:
PetPace has a moderate correlation with the most validated activity monitor that has been used in veterinary medicine, and its real-time data acquisition, user friendly interface for owners and cost make this device an attractive tool for monitoring activity in dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 25, 2019
2018 conference paper
Investigation of Sensory Thresholds in Cavalier King Charles Spaniels with and without Chiari-like Malformations and Syringomyelia
Pain in Animals Workshop 2017: Abstracts. Presented at the Pain in Animals Workshop 2017: Abstracts.
Event: Pain in Animals Workshop 2017: Abstracts
Sources: Crossref, NC State University Libraries
Added: January 25, 2020
2018 journal article
Investigation of sensory thresholds in Cavalier King Charles Spaniels with and without Chiari-like malformations and syringomyelia
Journal of Veterinary Internal Medicine, 32(6), 2021–2028.
author keywords: neuropathic pain; paresthesia; phantom scratch; syrinx
MeSH headings : Animals; Brain / diagnostic imaging; Brain / physiopathology; Budd-Chiari Syndrome / diagnostic imaging; Budd-Chiari Syndrome / physiopathology; Budd-Chiari Syndrome / veterinary; Case-Control Studies; Dog Diseases / diagnostic imaging; Dog Diseases / physiopathology; Dogs; Female; Hypesthesia / physiopathology; Hypesthesia / veterinary; Magnetic Resonance Imaging / veterinary; Male; Neuroimaging / veterinary; Sensory Thresholds / physiology; Syringomyelia / diagnostic imaging; Syringomyelia / physiopathology; Syringomyelia / veterinary
TL;DR:
Mechanical and thermal sensitivity does not appear to be related to the presence of SM, but mechanical sensitivity appears to berelated to the existence of pain and clinical signs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: December 31, 2018
2018 journal article
Measuring Distance Traveled with an Activity Monitor in Normal Dogs Participating in a 5K Race
Veterinary and Comparative Orthopaedics and Traumatology, 31(S 02), A1–A25.
Sources: Crossref, NC State University Libraries
Added: January 25, 2020
2018 chapter
Oral tumours
In J. Dobson & B. D. X. Lascelles (Eds.), BSAVA Manual of Oncology (3rd ed., pp. 191–201).
Ed(s): J. Dobson & B. Lascelles
Sources: NC State University Libraries, NC State University Libraries
Added: January 25, 2019
2018 conference paper
Pilot Evaluation of The Effect of Anti-nerve Growth Factor Antibody on Sensory System Function in Dogs with Degenerative Joint Disease-Associated Pain
Pain in Animals Workshop 2017: Abstracts. Presented at the Pain in Animals Workshop 2017: Abstracts.
Event: Pain in Animals Workshop 2017: Abstracts
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 25, 2020
2018 journal article
Pilot study evaluating the effect of feeding method on overall activity of neutered indoor pet cats
Journal of Veterinary Behavior, 25, 9–13.
author keywords: cat behavior; obesity; feeding method; activity; indoor
TL;DR:
Although the type of feeding method in this pilot study did not affect overall activity, providing meals to cats using food toys may provide other benefits related to satiety, stress reduction, and overall well‐being.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 29, 2019
2018 journal article
Prescribing Practices of Veterinarians in the Treatment of Chronic Musculoskeletal Pain in Cats
J Feline Med Surg, 7(6), 495–506.
author keywords: Musculoskeletal pain; analgesics; surveys; questionnaires
MeSH headings : Animals; Cat Diseases / drug therapy; Cats; Cross-Sectional Studies; Musculoskeletal Pain / drug therapy; Musculoskeletal Pain / veterinary; Practice Patterns, Physicians' / statistics & numerical data; Surveys and Questionnaires; Veterinarians / statistics & numerical data
TL;DR:
The results show a contrast between therapies prescribed by practitioners and what is supported by evidenced-based literature, and future research evaluating the safety and efficacy of gabapentin should be prioritised.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 25, 2019
2018 chapter
Principles of oncological surgery
In J. Dobson & B. D. X. Lascelles (Eds.), BSAVA Manual of Oncology (3rd ed., pp. 44–59).
Ed(s): J. Dobson & B. Lascelles
Sources: NC State University Libraries, NC State University Libraries
Added: January 25, 2019
2018 journal article
Quantitative sensory testing in dogs with painful disease: A window to pain mechanisms?
VETERINARY JOURNAL, 243, 33–41.
author keywords: Algoplasticity; Dog; Quantitative sensory testing
MeSH headings : Animals; Dog Diseases / diagnosis; Dog Diseases / etiology; Dogs; Pain / diagnosis; Pain / etiology; Pain / veterinary; Pain Measurement / instrumentation; Pain Measurement / methods; Pain Measurement / veterinary; Pain Threshold
TL;DR:
A narrative review describes the investigations into QST in clinical populations of dogs to date, and discusses the potential benefits and limitations of such testing.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 11, 2019
2018 journal article
Randomized Pilot Trial of the Effects of an Egg-Shell Membrane-Based Supplement (Movoflextm) on Mobility and Serum Biomarkers of Inflammation in Dogs with Osteoarthritis
Veterinary and Comparative Orthopaedics and Traumatology, 31(S 02), A1–A25.
Sources: Crossref, NC State University Libraries, ORCID
Added: December 3, 2019
2018 journal article
Replicate effects and test-retest reliability of quantitative sensory threshold testing in dogs with and without chronic pain
Veterinary Anaesthesia and Analgesia, 44(3), 615–624.
Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: August 6, 2018
2018 conference paper
Reverse Translation to Discover Relevant Targets for Chronic Pain: GFRA3/Artemin
Pain in Animals Workshop 2017: Abstracts. Presented at the Pain in Animals Workshop 2017: Abstracts.
Event: Pain in Animals Workshop 2017: Abstracts
Sources: Crossref, NC State University Libraries
Added: January 25, 2020
2018 journal article
Spontaneous painful disease in companion animals can facilitate the development of chronic pain therapies for humans
Osteoarthritis and Cartilage, 26(2), 175–183.
Source: ORCID
Added: January 22, 2019
2018 journal article
The Effectiveness of Marine-Based Fatty Acid Compound (PCSO-524) Alone and Combined with Previcox in the Treatment of Canine Osteoarthritis
Veterinary and Comparative Orthopaedics and Traumatology, 31(S 02), A1–A25.
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 25, 2020
2018 journal article
The pharmacokinetics and analgesic effects of extended-release buprenorphine administered subcutaneously in healthy dogs
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 41(4), 502–512.
author keywords: buprenorphine; dog; extended-release; pharmacodynamics; pharmacokinetics
MeSH headings : Analgesia / methods; Analgesia / veterinary; Analgesics, Opioid / administration & dosage; Analgesics, Opioid / blood; Analgesics, Opioid / pharmacokinetics; Analgesics, Opioid / pharmacology; Animals; Buprenorphine / administration & dosage; Buprenorphine / blood; Buprenorphine / pharmacokinetics; Buprenorphine / pharmacology; Delayed-Action Preparations; Dogs; Female; Injections, Subcutaneous / veterinary; Male
TL;DR:
Results showed that ER-buprenorphine administered at a dose of 0.2 mg/kg resulted in prolonged and sustained plasma concentrations and antinociceptive effects up to 72 hr after drug administration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2018 journal article
The pharmacokinetics of gabapentin in cats
JOURNAL OF VETERINARY INTERNAL MEDICINE, 32(6), 1996–2002.
author keywords: compounded; feline; pain; transdermal
MeSH headings : Analgesics / administration & dosage; Analgesics / blood; Analgesics / pharmacokinetics; Animals; Cats / metabolism; Female; Gabapentin / administration & dosage; Gabapentin / blood; Gabapentin / pharmacokinetics; Half-Life; Injections, Intravenous / veterinary; Male
TL;DR:
Repeated oral dosing of gabapentin did not alter the drug's pharmacokinetics, making dose adjustments unnecessary with long‐term treatment, and the transdermal route is an inappropriate choice for drug administration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 31, 2018
2018 conference paper
Translation of Activity Monitoring in Normal Dogs Towards Distance Travelled
Pain in Animals Workshop 2017: Abstracts. Presented at the Pain in Animals Workshop 2017: Abstracts.
Event: Pain in Animals Workshop 2017: Abstracts
Sources: Crossref, NC State University Libraries
Added: January 25, 2020
2018 chapter
Tumours of the respiratory system and thoracic cavity
In J. Dobson & B. D. X. Lascelles (Eds.), BSAVA Manual of Canine and Feline Oncology (3rd ed., pp. 265–284).
Ed(s): J. Dobson & B. Lascelles
TL;DR:
This chapter looks at tumours of the nasal planum, which are known to cause cancer of the nose and nasal cavity, and mesothelioma, which is a type of tumour found in the chest wall of the heart.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: January 25, 2019
2018 chapter
Tumours of the small intestines
In J. Dobson & B. D. X. Lascelles (Eds.), BSAVA Manual of Oncology (3rd ed., pp. 212–215).
Ed(s): J. Dobson & B. Lascelles
TL;DR:
This chapter covers presentation and clinical signs; clinical approach; management; prognosis of intestinal tumours in small animals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: January 25, 2019
2017 journal article
Assessment and Recognition of Chronic (Maladaptive) Pain
Feline Anesthesia and Pain Management, 241–256.
Source: ORCID
Added: January 22, 2019
2017 journal article
Caregiver placebo effect in analgesic clinical trials for cats with naturally occurring degenerative joint disease-associated pain
Veterinary Record, 180(19), 473–473.
MeSH headings : Analgesics / therapeutic use; Animals; Caregivers / psychology; Cat Diseases / drug therapy; Cats; Female; Humans; Joint Diseases / complications; Joint Diseases / veterinary; Male; Optimism; Osteoarthritis / complications; Osteoarthritis / veterinary; Pain / drug therapy; Pain / etiology; Pain / veterinary; Placebo Effect; Treatment Outcome
TL;DR:
The caregiver placebo effect across these clinical trials was remarkably high, making demonstration of efficacy for an analgesic above a placebo difficult, and further work is needed to determine whether a potential placebo-by-proxy effect could benefit cats in clinical settings.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2017 journal article
Chronic maladaptive pain in cats: A review of current and future drug treatment options
The Veterinary Journal, 230, 52–61.
author keywords: Maladaptive pain; Cats; Analgesia; Central plasticity; Chronic pain
MeSH headings : Analgesics / therapeutic use; Animals; Cat Diseases / diagnosis; Cat Diseases / drug therapy; Cats; Chronic Pain / diagnosis; Chronic Pain / drug therapy; Chronic Pain / veterinary; Forecasting; Pain Management / trends; Pain Management / veterinary; Pain Measurement / veterinary
TL;DR:
The current understanding of chronic or maladaptive pain, techniques for the detection and measurement of the condition and the associated central nervous changes, as well as an overview of the data evaluating potential therapeutics in cats are detailed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: January 22, 2019
2017 journal article
Defining local nerve blocks for feline distal pelvic limb surgery: a cadaveric study
JOURNAL OF FELINE MEDICINE AND SURGERY, 19(12), 1215–1223.
MeSH headings : Anesthetics, Local / administration & dosage; Animals; Cadaver; Cats / anatomy & histology; Female; Hindlimb / innervation; Hindlimb / surgery; Male; Methylene Blue / analogs & derivatives; Nerve Block / methods; Nerve Block / veterinary; Peroneal Nerve / anatomy & histology
TL;DR:
These two, three-point injection methods may be an effective perioperative analgesia technique for feline distal pelvic limb procedures.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2017 journal article
Development and preliminary validity and reliability of the montreal instrument for cat arthritis testing, for use by caretaker/owner, MI-CAT(C), via a randomised clinical trial
Applied Animal Behaviour Science, 200, 96–105.
author keywords: Behaviour; Degenerative joint disease/osteoarthritis; Pain measurement; Quality of life; Cats; NSAID
TL;DR:
A randomised, double-blinded, placebo-controlled, crossover clinical trial was conducted, and meloxicam efficacy in 54 OA-affected cats was evaluated using the MI-CAT(C)-v2 and locomotor activity monitoring (AM).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2017 journal article
Distinct neuronal populations in the basolateral and central amygdala are activated with acute pain, conditioned fear, and fear-conditioned analgesia
NEUROSCIENCE LETTERS, 661, 11–17.
author keywords: Nociception; Contextual fear; Fear-conditioned analgesia; Amygdala; cFos; Neural circuits
MeSH headings : Acute Pain / physiopathology; Amygdala / physiopathology; Analgesia / methods; Animals; Central Amygdaloid Nucleus / metabolism; Conditioning, Psychological / physiology; Fear / physiology; Male; Mice, Inbred C57BL; Neurons / metabolism; Pain Management; Periaqueductal Gray / metabolism; Periaqueductal Gray / physiopathology
TL;DR:
The results show that amygdala processing of conditioned contextual aversive, nociceptive, and FCA behaviors involve different neuronal phenotypes and neural circuits between, within, and from various amygdala nuclei.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2017 journal article
Evaluation of interobserver agreement for postoperative pain and sedation assessment in cats
Journal of the American Veterinary Medical Association, 251(5), 544–551.
MeSH headings : Analgesia; Animals; Bupivacaine; Buprenorphine; Cats / surgery; Female; Hysterectomy / veterinary; Observer Variation; Ovariectomy / veterinary; Pain Measurement / veterinary; Pain, Postoperative / diagnosis; Pathologists / psychology; Reproducibility of Results
TL;DR:
Interobserver differences in assessing pain can lead to different conclusions regarding treatment effectiveness, and interobserver agreements for pain scores were good, and that for sedation scores was fair.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: January 22, 2019
2017 journal article
Gait parameters in four strains of turkeys and correlations with bone strength
Poultry Science, 96(7), 1989–2005.
Source: ORCID
Added: January 22, 2019
2017 journal article
Generation of a stable transgenic swine model expressing a porcine histone 2b-egfp fusion protein for cell tracking and chromosome dynamics studies
PLoS One, 12(1).
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
Nocifensive Behaviors in Mice with Radiation-Induced Oral Mucositis
RADIATION RESEARCH, 187(3), 397–403.
MeSH headings : Animals; Behavior, Animal / radiation effects; Mice; Neurons / pathology; Neurons / radiation effects; Nociception / radiation effects; Radiation Injuries, Experimental / pathology; Radiation Injuries, Experimental / physiopathology; Stomatitis / pathology; Stomatitis / physiopathology; Trigeminal Ganglion / pathology
TL;DR:
Data validate an appropriate model for cancer treatment related discomfort in humans and quantify resultant discomfort, and characterize peripheral sensitization following radiation-induced glossitis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2017 journal article
Pharmacokinetics and pharmacodynamics of an extended-release buprenorphine formulation in dogs
Veterinary Anaesthesia and Analgesia, 44(1), 195.e6.
Sources: Crossref, ORCID
Added: January 22, 2019
2017 journal article
Pharmacokinetics of liposomal encapsulated buprenorphine suspension following subcutaneous administration to cats
Journal of Veterinary Pharmacology and Therapeutics, 40(3), 256–269.
Source: ORCID
Added: January 22, 2019
2017 journal article
Pilot evaluation of a novel unilateral onychectomy model and efficacy of an extended release buprenorphine product
BMC Veterinary Research, 13.
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
Quality assurance and best research practices for non-regulated veterinary clinical studies
BMC VETERINARY RESEARCH, 13.
MeSH headings : Animals; Clinical Trials as Topic / veterinary; Practice Guidelines as Topic / standards; Quality Control; Reproducibility of Results; Research Design / standards
TL;DR:
The purpose of this first of a series of statement papers is to outline and reference specific quality control and quality assurance procedures that should, at least in part, be incorporated into all veterinary clinical studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2017 journal article
Questionnaire-based Analysis of Owner-reported Scratching and Pain Signs in Cavalier King Charles Spaniels Screened for Chiari-like Malformation and Syringomyelia
Journal of Veterinary Internal Medicine, 32(1), 331–339.
author keywords: Neuropathic pain; Paresthesia; Phantom scratch; Syrinx
MeSH headings : Animals; Arnold-Chiari Malformation / diagnostic imaging; Arnold-Chiari Malformation / pathology; Arnold-Chiari Malformation / veterinary; Dog Diseases / diagnosis; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Dogs; Female; Magnetic Resonance Imaging / veterinary; Male; Neuroimaging / veterinary; Pain / pathology; Pain / veterinary; Pruritus / pathology; Pruritus / veterinary; Surveys and Questionnaires; Syringomyelia / diagnostic imaging; Syringomyelia / pathology; Syringomyelia / veterinary
TL;DR:
Lack of association of owner‐reported signs with SM highlights the lack of understanding of the pathophysiology of pain in this disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2017 journal article
Repeatability and accuracy testing of a weight distribution platform and comparison to a pressure sensitive walkway to assess static weight distribution
VETERINARY AND COMPARATIVE ORTHOPAEDICS AND TRAUMATOLOGY, 30(2), 160–164.
author keywords: Pressure sensitive walkway; static weight distribution; weight distribution platform; repeatability
MeSH headings : Animals; Body Weight; Dogs / physiology; Posture; Pressure; Reproducibility of Results; Veterinary Medicine / instrumentation; Walking / physiology
TL;DR:
The weight distribution platform is a repeatable and accessible device to measure static weight distribution, and if proven the same in a clinical setting, it will be a valuable addition to current objective measures of limb use.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2017 journal article
Replicate effects and test–retest reliability of quantitative sensory threshold testing in dogs with and without chronic pain
Veterinary Anaesthesia and Analgesia, 44(3), 615–624.
author keywords: central sensitization; chronic pain; dogs; quantitative sensory testing; replicate effect
MeSH headings : Animals; Chronic Pain / physiopathology; Chronic Pain / veterinary; Cold Temperature; Dog Diseases / physiopathology; Dogs; Hot Temperature; Osteoarthritis / physiopathology; Osteoarthritis / veterinary; Pain Measurement; Pain Threshold / physiology; Pressure; Prospective Studies; Reproducibility of Results; Sensory Thresholds / physiology
TL;DR:
Evaluated replicate effects and test-retest reliability of mechanical and thermal quantitative sensory testing (QST) in normal dogs and dogs with osteoarthritis-associated pain showed variability over time, particularly for EVF and hot thermal stimuli.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: June 30, 2019
2017 review
Spontaneous painful disease in companion animals can facilitate the development of chronic pain therapies for humans
[Review of ]. OSTEOARTHRITIS AND CARTILAGE, 26(2), 175–183.
author keywords: Osteoarthritis; Pain; Model; Spontaneous disease; Dog; Cat
MeSH headings : Animals; Arthritis, Experimental / drug therapy; Chronic Pain / drug therapy; Chronic Pain / veterinary; Drug Development / methods; Humans; Osteoarthritis / drug therapy; Osteoarthritis / veterinary; Pain Management / methods; Pets; Translational Research, Biomedical / methods
TL;DR:
The role that spontaneous osteoarthritis in companion animals can play in translational research and therapeutic pharmacological development is outlined and the opportunity for target discovery exists but is, as yet, unproven.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2017 journal article
The use of functional data analysis to evaluate activity in a spontaneous model of degenerative joint disease associated pain in cats
PloS One, 12(1), e0169576.
Source: ORCID
Added: January 22, 2019
2017 review
Translational pain assessment: could natural animal models be the missing link?
[Review of ]. PAIN, 158(9), 1633–1646.
author keywords: Preclinical animal models; Natural; Experimental; Validity; Applicability; Translation
MeSH headings : Analgesics / therapeutic use; Animals; Dogs; Gray Matter / diagnostic imaging; Humans; Magnetic Resonance Imaging; Male; Models, Animal; Osteoarthritis / complications; Osteoarthritis / diagnosis; Osteoarthritis / veterinary; Pain / diagnosis; Pain / drug therapy; Pain / etiology; Pain / veterinary; Pain Measurement / methods; Translational Research, Biomedical / methods
TL;DR:
This review describes numerous conditions similarly applicable to pain research, with potential mutual benefits for human and veterinary clinicians, and their respective patients.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2017 journal article
Translational pain assessment: could natural animal models be the missing link?
Pain, 158(9), 1633–1646.
Source: ORCID
Added: January 22, 2019
2017 journal article
Validated Outcomes Measures for Canine Osteoarthritis
Vet Surg, 46(3), 341–342.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: January 22, 2019
2016 journal article
A Feline-Specific Anti-Nerve Growth Factor Antibody Improves Mobility in Cats with Degenerative Joint Disease-Associated Pain: A Pilot Proof of Concept Study
Journal of Veterinary Internal Medicine, 30(4), 1138–1148.
author keywords: Client-specific outcome measures; Feline musculoskeletal pain index; Osteoarthritis
MeSH headings : Analgesics, Non-Narcotic / therapeutic use; Animals; Antibodies, Monoclonal / therapeutic use; Cat Diseases / therapy; Cats; Double-Blind Method; Female; Injections, Subcutaneous / veterinary; Lameness, Animal / therapy; Male; Nerve Growth Factor / immunology; Osteoporosis / therapy; Osteoporosis / veterinary; Pain, Intractable / therapy; Pain, Intractable / veterinary; Pilot Projects; Species Specificity; Treatment Outcome
TL;DR:
A 6‐week duration positive analgesic effect of this fully felinized anti‐NGF antibody in cats suffering from DJD‐associated pain is demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2016 journal article
A comparison of serum and plasma cytokine values using a multiplexed assay in cats
Veterinary Immunology and Immunopathology, 182, 69–73.
author keywords: Biomarker; Immunoassay; Feline
MeSH headings : Animals; Biomarkers / blood; Blood Chemical Analysis / methods; Cats / blood; Cats / immunology; Cytokines / blood; Immunoassay / methods; Plasma / immunology
TL;DR:
While serum and plasma agreement was generally good, detection was improved using serum samples, and alterations of cytokine concentrations have been associated with joint deterioration and pain in humans, similar changes have not been investigated in cats.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2016 journal article
A data-driven weighting scheme for multivariate phenotypic endpoints recapitulates zebrafish developmental cascades
TOXICOLOGY AND APPLIED PHARMACOLOGY, 314, 109–117.
Contributors: G. Zhang n, K. Roell n, L. Truong *, R. Tanguay * & D. Reif n
author keywords: Zebrafish; High-dimensional; Bayesian; Developmental cascade; ToxRefDB; Risk assessment; Multiple endpoints; Multivariate; Scoring
MeSH headings : Animals; Models, Theoretical; Multivariate Analysis; Phenotype; Zebrafish / embryology
TL;DR:
The results suggest that developmental cascade effects triggered by chemical exposure can be recapitulated by analyzing the relationships among endpoints, and wAggE offers a powerful approach for analysis of multivariate phenotypes that can reveal underlying etiological processes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 review
Aging in cats: Common physical and functional changes
[Review of ]. JOURNAL OF FELINE MEDICINE AND SURGERY, 18(7), 533–550.
MeSH headings : Aging; Animals; Cats / physiology; Physical Examination / veterinary
TL;DR:
A thorough, systems-based overview of common health-related changes observed in cats as they age is provided, drawing on expert opinion and available data in both the cat and other species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
Aging in cats: Common physical and functional changes
Journal of Feline Medicine and Surgery, 18(7), 533–550.
Source: ORCID
Added: January 22, 2019
2016 journal article
Alfaxalone Anaesthesia Facilitates Electrophysiological Recordings of Nociceptive Withdrawal Reflexes in Dogs (Canis familiaris)
PLOS ONE, 11(7).
MeSH headings : Anesthesia / methods; Anesthetics / administration & dosage; Animals; Consciousness / drug effects; Dogs; Electrophysiological Phenomena; Male; Osteoarthritis / diagnosis; Osteoarthritis / physiopathology; Osteoarthritis / veterinary; Pain / diagnosis; Pain / drug therapy; Pain / veterinary; Pregnanediones / administration & dosage; Reflex / drug effects
TL;DR:
Development of a suitable anaesthetic protocol in experimental dogs, which facilitated electrophysiological nociceptive withdrawal reflex assessment, may increase the acceptability of using the technique in owned dogs with naturally occurring osteoarthritis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 review
An extended release local anaesthetic: potential for future use in veterinary surgical patients?
[Review of ]. VETERINARY MEDICINE AND SCIENCE, 2(4), 229–238.
author keywords: bupivacaine liposome injectable suspension; pain; perioperative; dog
TL;DR:
There is a clear unmet need for a long‐acting local anaesthetic that can be added to the multimodal analgesic protocol to provide pain relief to patients in the home environment or during extended hospitalization.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
Association of Canine Osteosarcoma and Monocyte Phenotype and Chemotactic Function
Journal of Veterinary Internal Medicine, 30(4), 1167–1178.
author keywords: Bone tumor; Chemoreceptors; Chemotaxis; Immunoregulation
MeSH headings : Animals; Bone Neoplasms / blood; Bone Neoplasms / veterinary; Case-Control Studies; Chemotaxis; Cytokines / metabolism; Disease-Free Survival; Dog Diseases / blood; Dogs; Female; Flow Cytometry / veterinary; Gene Expression Regulation; Male; Monocytes / metabolism; Monocytes / physiology; Osteosarcoma / blood; Osteosarcoma / veterinary; RNA, Messenger / analysis
TL;DR:
Dogs with OSA have decreased monocyte chemokine receptor expression and monocytes chemotaxis, potential mechanisms by which OSA might evade the immune response, and reversal of monocyte dysfunction using immunotherapy could improve survival in dogs with Osa.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2016 journal article
Attitudes of small animal practitioners toward participation in veterinary clinical trials
Journal of the American Veterinary Medical Association, 250(1), 86–97.
MeSH headings : Animals; Attitude of Health Personnel; Clinical Trials as Topic / veterinary; Cross-Sectional Studies; Data Collection; Humans; Pets; Research / organization & administration; Veterinarians; Veterinary Medicine / methods
TL;DR:
Attitudes of small animal practitioners toward veterinary clinical trials and variables influencing their likelihood of participating in such trials were determined and efforts should be increased to raise practitioner awareness of clinical trials for which patients might qualify.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018
2016 journal article
Clinical metrology instrument administration: evaluation of baseline variability and the effect of independent versus dependent interviewing on pain and mobility scores in dogs with osteoarthritis.
Journal of Veterinary Internal Medicine, 30(3), 836–846.
Source: NC State University Libraries
Added: September 8, 2019
2016 journal article
Clinical safety of robenacoxib in feline osteoarthritis: results of a randomized, blinded, placebo-controlled clinical trial
Journal of Feline Medicine and Surgery, 18(8), 632–642.
Source: ORCID
Added: January 22, 2019
2016 journal article
Comparison of thermal and mechanical quantitative sensory testing in client-owned dogs with chronic naturally occurring pain and normal dogs
The Veterinary Journal, 210, 95–97.
Contributors: M. Freire n, D. Knazovicky n , B. Case n, A. Thomson n & B. Lascelles n
author keywords: Canine; Central Sensitization; Chronic pain; Mechanical sensory threshold; Thermal sensory threshold
MeSH headings : Animals; Central Nervous System Sensitization; Dog Diseases / physiopathology; Dogs; Osteoarthritis / physiopathology; Osteoarthritis / veterinary; Pain / physiopathology; Pain / veterinary; Sensory Thresholds
TL;DR:
Whether QST is different between dogs with chronic pain and normal dogs needs further investigation using a larger group of animals and age, weight and sex matched groups.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, ORCID
Added: January 22, 2019
2016 journal article
Do cats with a cranial cruciate ligament injury and osteoarthritis demonstrate a different gait pattern and behavior compared to sound cats?
Acta Vet Scand, 58(Suppl 1).
author keywords: Feline; Cranial cruciate ligament; Pain questionnaire; Owner assessment; Pressure mat technique
MeSH headings : Animals; Anterior Cruciate Ligament Injuries / complications; Anterior Cruciate Ligament Injuries / veterinary; Behavior, Animal / physiology; Cat Diseases / etiology; Cat Diseases / pathology; Cats; Female; Gait / physiology; Humans; Lameness, Animal / etiology; Male; Osteoarthritis / complications; Osteoarthritis / veterinary; Surveys and Questionnaires
TL;DR:
It is indicated that cats with a previous CCL injury put less weight, on the affected hindlimb but for a longer time, and improved assessment tools for chronic pain caused by OA in cats are needed, both to facilitate diagnosis and to evaluate pain-relieving treatment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2016 journal article
Dolor articular en perros y gatos domésticos
Source: ORCID
Added: January 22, 2019
2016 journal article
Douleur articulaire chez les chiens et chats
Source: ORCID
Added: January 22, 2019
2016 review
Evaluating aging in cats: How to determine what is healthy and what is disease
[Review of ]. JOURNAL OF FELINE MEDICINE AND SURGERY, 18(7), 551–570.
MeSH headings : Aging; Animals; Cat Diseases / diagnosis; Cat Diseases / physiopathology; Cats / physiology; Physical Examination / veterinary; Quality of Life
TL;DR:
This second review proposes criteria for assessing ‘healthy aged cats’ and draws on expert opinion and available data in both the cat and other species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
Evaluating aging in cats: How to determine what is healthy and what is disease
Journal of Feline Medicine and Surgery, 18(7), 551–570.
Source: ORCID
Added: January 22, 2019
2016 journal article
Evaluation of Clinical Metrology Instrument in Dogs with Osteoarthritis
Journal of Veterinary Internal Medicine, 30(3), 836–846.
author keywords: Analgesia; Client metrology instrument; Degenerative joint disease; Questionnaire
MeSH headings : Animals; Antibodies / immunology; Antibodies / therapeutic use; Dog Diseases / immunology; Dog Diseases / physiopathology; Dog Diseases / therapy; Dogs; Double-Blind Method; Immunotherapy / veterinary; Nerve Growth Factor / immunology; Osteoarthritis / physiopathology; Osteoarthritis / therapy; Osteoarthritis / veterinary; Pain / drug therapy; Pain / veterinary; Pain Measurement / veterinary; Pilot Projects; Proof of Concept Study
TL;DR:
There is little difference between independent and dependent interviewing, however, dependent interviewing resulted in increased treatment effect sizes and investigators could increase clinical trial power through minimal change to study design.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2016 journal article
Evaluation of serum cytokines in cats with and without degenerative joint disease and associated pain
Veterinary Immunology and Immunopathology, 183, 49–59.
author keywords: Biomarker; Immunoassay; Multiplex; Arthritis
MeSH headings : Animals; Cat Diseases / blood; Cat Diseases / physiopathology; Cats; Cytokines / blood; Female; Male; Osteoarthritis / blood; Osteoarthritis / diagnostic imaging; Osteoarthritis / physiopathology; Osteoarthritis / veterinary; Pain / veterinary; Radiography / veterinary
TL;DR:
Evaluating the concentration of cytokines and chemokines in serum samples obtained from cats with and without degenerative joint disease and associated pain showed that cats with higher radiographic degenerative joints disease scores have higher serum concentrations of IL-4 and IL-8, while Cats with higher orthopedic exam pain scores haveHigher concentrations ofIL-8.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: January 22, 2019
2016 journal article
Functional outcome measures in a surgical model of hip osteoarthritis in dogs
Journal of Experimental Orthopaedics, 3(1), 17.
Source: ORCID
Added: January 22, 2019
2016 journal article
In Vitro and In Vivo Characterization of a Fully Felinized Therapeutic Anti-Nerve Growth Factor Monoclonal Antibody for the Treatment of Pain in Cats
JOURNAL OF VETERINARY INTERNAL MEDICINE, 30(4), 1129–1137.
author keywords: Cat pain; Companion animals; Feline analgesia; PETization; Pharmacokinetics
MeSH headings : Analgesics, Non-Narcotic / pharmacokinetics; Analgesics, Non-Narcotic / therapeutic use; Animals; Antibodies, Monoclonal / pharmacokinetics; Antibodies, Monoclonal / therapeutic use; Cat Diseases / therapy; Cats; Female; Lameness, Animal / therapy; Male; Nerve Growth Factor / immunology; Osteoarthritis / therapy; Osteoarthritis / veterinary; Pain Management / veterinary; Pain, Intractable / therapy; Pain, Intractable / veterinary; Species Specificity; Treatment Outcome
TL;DR:
The high affinity, long plasma half‐life, safety, and analgesic efficacy of felinized anti‐NGF mAb (NV‐02) support further investigation of the analgesic potential of this antibody in the cat.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
In vitro and in vivo characterization of a fully felinized therapeutic anti-nerve growth factor monoclonal antibody for the treatment of pain in cats
Journal of Veterinary Internal Medicine, 30(4), 1129–1137.
Source: ORCID
Added: January 22, 2019
2016 journal article
Joint Pain in Pet Dogs and Cats
Source: ORCID
Added: January 22, 2019
2016 journal article
Mechanical and Thermal Sensory Testing in Normal Chondrodystrophoid Dogs and Dogs with Spinal Cord Injury caused by Thoracolumbar Intervertebral Disc Herniations
Journal of Veterinary Internal Medicine, 30(2), 627–635.
Contributors: A. Gorney n, S. Blau n, C. Dohse n, E. Griffith n, K. Williams n, J. Lim n, D. Knazovicky n , B. Lascelles n, N. Olby n
author keywords: Allodynia; Mechanical threshold; Nociception; Quantitative sensory testing; Thermal threshold
MeSH headings : Animals; Cold Temperature; Dog Diseases / diagnosis; Dogs; Female; Hot Temperature; Intervertebral Disc Displacement / diagnosis; Intervertebral Disc Displacement / veterinary; Male; Pressure; Sensory Thresholds / physiology; Spinal Cord Injuries / diagnosis; Spinal Cord Injuries / veterinary
TL;DR:
The differences in sensation among neurologic grades indicate that these techniques can be used to further characterize recovery of SCI dogs and can be measured reliably in chondrodystrophoid dogs and are altered by SCI.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2016 journal article
Pharmacokinetics of bupivacaine after intraperitoneal administration to cats undergoing ovariohysterectomy
AMERICAN JOURNAL OF VETERINARY RESEARCH, 77(6), 641–645.
MeSH headings : Anesthesia / veterinary; Anesthetics, Local / administration & dosage; Anesthetics, Local / blood; Anesthetics, Local / pharmacokinetics; Anesthetics, Local / pharmacology; Animals; Biological Availability; Bupivacaine / administration & dosage; Bupivacaine / blood; Bupivacaine / pharmacokinetics; Bupivacaine / pharmacology; Buprenorphine / administration & dosage; Cats / blood; Female; Half-Life; Hysterectomy / veterinary; Isoflurane; Meloxicam; Ovariectomy / veterinary; Propofol; Thiazines; Thiazoles
TL;DR:
Intraperitoneal administration of bupivacaine resulted in concentrations that did not cause observable toxicosis and studies to investigate analgesic effects for this technique in cats are warranted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
Pilot evaluation of a novel unilateral onychectomy model and efficacy of an extended release buprenorphine product
BMC Veterinary Research, 13(1), 32.
Source: ORCID
Added: January 22, 2019
2016 journal article
Pilot, randomized, placebo-controlled clinical field study to evaluate the effectiveness of bupivacaine liposome injectable suspension for the provision of post-surgical analgesia in dogs undergoing stifle surgery
BMC Veterinary Research, 12(1).
author keywords: Bupivacaine liposome injectable suspension; Dog; Pain; Cruciate surgery
MeSH headings : Analgesia / veterinary; Anesthetics, Local / administration & dosage; Anesthetics, Local / pharmacology; Animals; Bupivacaine / administration & dosage; Bupivacaine / pharmacology; Dog Diseases / surgery; Dogs; Female; Liposomes; Male; Pain, Postoperative / prevention & control; Pain, Postoperative / veterinary; Pilot Projects; Stifle / surgery
TL;DR:
AT-003 (bupivacaine liposome injectable suspension) provided measurable local analgesia over a 72-h period following post-stifle surgery surgical site tissue infiltration.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2016 journal article
Severity of Nasal Inflammatory Disease Questionnaire for Canine Idiopathic Rhinitis Control: Instrument Development and Initial Validity Evidence
JOURNAL OF VETERINARY INTERNAL MEDICINE, 31(1), 134–141.
author keywords: Lymphoplasmacytic; Psychometrics; Survey
MeSH headings : Animals; Case-Control Studies; Dog Diseases / prevention & control; Dogs; Female; Humans; Male; Ownership; Pain, Intractable / prevention & control; Pain, Intractable / veterinary; Quality of Life; Reproducibility of Results; Rhinitis / prevention & control; Rhinitis / veterinary; Severity of Illness Index; Surveys and Questionnaires; Symptom Assessment
TL;DR:
The SNIFLD questionnaire provides a mechanism for repeated assessments of disease severity in dogs with chronic rhinitis and strong psychometric evidence was available to support the substantive, generalizability, content, and structural aspects of construct validity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
Widespread somatosensory sensitivity in naturally occurring canine model of osteoarthritis
PAIN, 157(6), 1325–1332.
Contributors: D. Knazovicky n , E. Helgeson n, B. Case n, M. Gruen n , W. Maixner n & B. Lascelles n
author keywords: Animal model; Osteoarthritis; Spontaneous osteoarthritis model; Quantitative sensory testing
MeSH headings : Animals; Arthralgia / physiopathology; Arthralgia / veterinary; Central Nervous System Sensitization / physiology; Dogs; Osteoarthritis / physiopathology; Osteoarthritis / veterinary; Pain Measurement; Pain Threshold / physiology; Physical Stimulation; Sensory Thresholds / physiology
TL;DR:
The canine spontaneous OA model is associated with somatosensory sensitivity, likely indicative of central sensitization in human patients' chronic pain, and is validated as an appropriate model of the human OA pain condition.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2016 journal article
ペット (イヌ, ネコ) の関節痛
Source: ORCID
Added: January 22, 2019
2015 journal article
A canine-specific anti-nerve growth factor antibody alleviates pain and improves mobility and function in dogs with degenerative joint disease-associated pain
BMC VETERINARY RESEARCH, 11(1).
Contributors: B. Lascelles n, D. Knazovicky n , B. Case n, M. Freire *, J. Innes, A. Drew*, D. Gearing*
author keywords: Nerve growth factor; Dog; Antibody; Pain; Model; Osteoarthritis; Accelerometry; Actimetry
MeSH headings : Animals; Antibodies / immunology; Antibodies / therapeutic use; Dog Diseases / therapy; Dogs; Double-Blind Method; Female; Immunotherapy / veterinary; Male; Nerve Growth Factor / immunology; Osteoarthritis / therapy; Osteoarthritis / veterinary; Pain / drug therapy; Pain / veterinary
TL;DR:
These pilot data demonstrate a positive analgesic effect of anti-NGF antibody in dogs suffering from chronic pain, similar to that expected with an NSAID.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
Analgesic efficacy of intraperitoneal administration of bupivacaine in cats
JOURNAL OF FELINE MEDICINE AND SURGERY, 18(11), 906–912.
MeSH headings : Analgesics, Opioid / administration & dosage; Anesthesia / veterinary; Anesthetics, Local / administration & dosage; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Buprenorphine / administration & dosage; Cats / physiology; Cats / surgery; Female; Hysterectomy / veterinary; Injections, Intraperitoneal / veterinary; Meloxicam; Ovariectomy / veterinary; Pain Measurement / veterinary; Pain, Postoperative / prevention & control; Pain, Postoperative / veterinary; Prospective Studies; Thiazines / administration & dosage; Thiazoles / administration & dosage; Treatment Outcome
TL;DR:
Based on rescue analgesia, IP administration of bupivacaine provides analgesia in cats after OVH and the DIVAS, MCPS and MNT were significantly different when compared with baseline values at different time points; however, data were not significantly different among groups.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
Assessment of an implant-skin interface scoring system for external skeletal fixation of dogs
American Journal of Veterinary Research, 76(11), 931–938.
MeSH headings : Animals; Dogs; External Fixators / veterinary; Fracture Fixation; Inflammation; Observer Variation; Orthopedics / methods; Orthopedics / standards; Photography; Reproducibility of Results; Skin / pathology; Veterinary Medicine / methods; Veterinary Medicine / standards
TL;DR:
An ISI scoring system used in this study had high repeatability and agreement and may therefore be considered for use in clinical situations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
Clinical safety of robenacoxib in feline osteoarthritis: results of a randomized, blinded, placebo-controlled clinical trial
JOURNAL OF FELINE MEDICINE AND SURGERY, 18(8), 632–642.
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / adverse effects; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Cat Diseases / drug therapy; Cats; Diphenylamine / adverse effects; Diphenylamine / analogs & derivatives; Diphenylamine / therapeutic use; Osteoarthritis / drug therapy; Osteoarthritis / veterinary; Phenylacetates / adverse effects; Phenylacetates / therapeutic use
TL;DR:
Robenacoxib was well tolerated when administered daily for 1 month in cats with osteoarthritis, including cats with evidence of concurrent CKD, and there was no clinical indication of damage to the gastrointestinal tract, kidney or liver.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
Criterion validation testing of clinical metrology instruments for measuring degenerative joint disease associated mobility impairment in cats
PLoS One, 10(7), e0131839.
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
2015 journal article
Defining the local nerve blocks for feline distal thoracic limb surgery: a cadaveric study
JOURNAL OF FELINE MEDICINE AND SURGERY, 18(10), 838–845.
MeSH headings : Animals; Cadaver; Cats / anatomy & histology; Female; Forelimb / innervation; Forelimb / surgery; Male; Median Nerve / anatomy & histology; Nerve Block / veterinary; Radial Nerve / anatomy & histology; Ulnar Nerve / anatomy & histology
TL;DR:
A four-point injection method based on cadaveric dissections and tested using dye injections may be an effective perioperative analgesia technique for feline distal thoracic limb procedures.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
Guidelines for recognition, assessment and treatment of pain
The Veterinary Nurse, 6(3), 164–173.
Source: ORCID
Added: January 22, 2019
2015 journal article
Initial evaluation of a canine stifle arthrotomy post-operative pain model
VETERINARY JOURNAL, 204(3), 293–298.
author keywords: Arthrotomy; Ground reaction force; Pain model; Percentage bodyweight distribution; Symmetry index; Extended-release buprenorphine
MeSH headings : Analgesics, Opioid / administration & dosage; Analgesics, Opioid / pharmacology; Animals; Buprenorphine / administration & dosage; Buprenorphine / pharmacology; Cross-Over Studies; Delayed-Action Preparations; Dogs; Male; Orthopedic Procedures / adverse effects; Orthopedic Procedures / veterinary; Pain Measurement / veterinary; Pain, Postoperative / drug therapy; Pain, Postoperative / pathology; Pain, Postoperative / veterinary; Stifle / surgery
TL;DR:
Subjective assessments did not detect the pain-inducing effects of arthrotomy or pain-alleviating effects of treatment, and subjective measures of procedural pain in research dogs need to be developed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
Initial evaluation of nighttime restlessness in a naturally occurring canine model of osteoarthritis pain
PeerJ, 3(2), e772.
Contributors: D. Knazovicky n , A. Tomas n, A. Motsinger-Reif n & B. Lascelles n
author keywords: Accelerometry; Dog; Pain; Model; Spontaneous; Accelerometry
TL;DR:
Although accelerometry does not appear to be useful, this model has potential to model the human pain-related nighttime sleep disturbance, and other outcome measures should be explored in this model.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2015 journal article
Prescription of perioperative analgesics by UK small animal veterinary surgeons in 2013
VETERINARY RECORD, 176(19).
author keywords: Analgesia; Cats; Dogs; Welfare
MeSH headings : Analgesia / veterinary; Analgesics / therapeutic use; Animals; Attitude of Health Personnel; Cats; Cross-Sectional Studies; Dogs; Drug Prescriptions / statistics & numerical data; Drug Prescriptions / veterinary; Female; Health Care Surveys; Humans; Male; Practice Patterns, Physicians' / statistics & numerical data; United Kingdom; Veterinarians / psychology; Veterinarians / statistics & numerical data
TL;DR:
A cross-sectional survey of UK practising small animal veterinary surgeons was undertaken in spring 2013, finding that analgesic prescription has increased since previous surveys, which should translate to improved animal welfare.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
the analgesic efficacy of intraperitoneal administration of bupivacaine in cats: 16.1.
Journal of Veterinary Pharmacology and Therapeutics, 38, 163.
Source: ORCID
Added: January 22, 2019
2014 journal article
Acute pain in cats: Treatment with NSAIDs
Today’s Veterinary Practice, May/June.
Source: NC State University Libraries
Added: January 25, 2019
2014 journal article
CLINICAL TRIALS INVOLVING CATS What factors affect owner participation?
JOURNAL OF FELINE MEDICINE AND SURGERY, 16(9), 727–735.
MeSH headings : Animals; Cat Diseases / therapy; Cats; Clinical Trials as Topic / veterinary; Pilot Projects; Research Design; Veterinarians / psychology
TL;DR:
The most influential factors were trust in the organization, benefit to the cat and veterinarian recommendation, which were not significantly different across groups, with ‘Free Services’ ranked highest.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2014 report
Challenges in evaluation of pain and a pre-incisional line block
PeerJ PrePrints.
Source: ORCID
Added: January 22, 2019
2014 personal communication
Chronic kidney disease in cats
Source: NC State University Libraries
Added: August 6, 2018
2014 journal article
Chronic kidney disease in cats.
Journal of the American Veterinary Medical Association, 244(7), 775.
Source: ORCID
Added: January 22, 2019
2014 journal article
Detection of Clinically Relevant Pain Relief in Cats with Degenerative Joint Disease Associated Pain
JOURNAL OF VETERINARY INTERNAL MEDICINE, 28(2), 346–350.