Works (56)

Updated: July 9th, 2024 05:02

2024 journal article

Inhalation of ACE2-expressing lung exosomes provides prophylactic protection against SARS-CoV-2

NATURE COMMUNICATIONS, 15(1).

By: Z. Wang*, S. Hu*, K. Popowski n, S. Liu*, D. Zhu*, X. Mei n, J. Li*, Y. Hu* ...

Sources: Web Of Science, NC State University Libraries
Added: April 8, 2024

2024 journal article

Optimizing cell therapy by sorting cells with high extracellular vesicle secretion

NATURE COMMUNICATIONS, 15(1).

By: D. Koo*, X. Cheng n, S. Udani*, S. Baghdasarian*, D. Zhu*, J. Li*, B. Hall, N. Tsubamoto* ...

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: July 8, 2024

2023 journal article

A SARS-CoV-2 and influenza double hit vaccine based on RBD-conjugated inactivated influenza A virus

SCIENCE ADVANCES, 9(25).

By: Z. Wang n, Z. Li n, W. Shi n, D. Zhu n, S. Hu n, P. Dinh n, K. Cheng n

MeSH headings : Cricetinae; Animals; Humans; Mice; Influenza Vaccines; SARS-CoV-2; Influenza, Human; Influenza A Virus, H1N1 Subtype; Pandemics; COVID-19 / prevention & control; COVID-19 Vaccines; Influenza A virus
TL;DR: The Flu-RBD VLP vaccine is a promising candidate for combating COVID-19, influenza A, and coinfection and elicited a strong neutralization activity against both SARS-CoV-2 Delta pseudovirus and wild-type influenza A H1N1 inactivated virus in mice. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 24, 2023

2023 journal article

An inhaled bioadhesive hydrogel to shield non-human primates from SARS-CoV-2 infection

Nature Materials, 2.

By: X. Mei n, J. Li n, Z. Wang n, D. Zhu n, K. Huang n, S. Hu n, K. Popowski n, K. Cheng n

TL;DR: A physical barrier against SARS-CoV-2 infection based on an inhalable bioadhesive hydrogel, named spherical hydrogels inhalation for enhanced lung defence (SHIELD), which is conveniently delivered via a dry powder inhaler and made with food-grade materials and does not affect normal respiratory functions. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: March 6, 2023

2023 journal article

Comparison of extruded cell nanovesicles and exosomes in their molecular cargos and regenerative potentials

NANO RESEARCH, 16(5), 7248–7259.

By: X. Wang*, S. Hu n, D. Zhu n, J. Li n, K. Cheng n & G. Liu

author keywords: nanovesicles (NVs); exosomes; cardiac repair; mesenchymal stem cells (MSCs); extracellular vesicles (EVs); myocardial infarction (Ml)
TL;DR: Proteomics and RNA sequencing data revealed that NVs resemble MSCs more closely than EVs, and microRNAs in NVs are related to cardiac repair, fibrosis repression, and angiogenesis. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 28, 2023

2023 journal article

Intrapericardial long non-coding RNA–<i>Tcf21</i> antisense RNA inducing demethylation administration promotes cardiac repair

European Heart Journal, 44(19), 1748–1760.

By: D. Zhu n, S. Liu n, K. Huang n, J. Li n, X. Mei n, Z. Li n, K. Cheng n

author keywords: Myocardial infarction; Adverse remodelling; Mesenchymal stem cell; EVs; lncRNA; Tcf21
MeSH headings : Mice; Animals; Swine; RNA, Long Noncoding / genetics; RNA, Long Noncoding / metabolism; RNA, Antisense / genetics; RNA, Antisense / metabolism; Ventricular Remodeling; Myocardial Infarction / genetics; Myocardial Infarction / therapy; Myocardial Infarction / metabolism; Fibrosis; Demethylation
TL;DR: Novel mechanisms underlying EV therapy for improving adverse remodelling are established and a lncRNA therapy for cardiac fibrosis is proposed, which could be a promising way to treat myocardial fibrosis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: April 4, 2023

2023 article

Pericardial Delivery of SDF-1 α Puerarin Hydrogel Promotes Heart Repair and Electrical Coupling

Luo, L., Li, Y., Bao, Z., Zhu, D., Chen, G., Li, W., … Li, Z. (2023, September 15). ADVANCED MATERIALS, Vol. 9.

By: L. Luo*, Y. Li*, Z. Bao*, D. Zhu n, G. Chen*, W. Li*, Y. Xiao*, Z. Wang n ...

author keywords: cardiac arrhythmias; electrical coupling; endogenous repair; inflammation regulation; myocardial infarction; SDF-1
TL;DR: SDF‐1α‐encapsulated Puerarin (PUE) hydrogel (SDF‐1α@PUE) is capable of enhancing endogenous stem cell homing and simultaneously polarizing the recruited monocyte/macrophages into a repairing phenotype, demonstrating a promising therapeutic platform for MI that not only facilitates heart regeneration but also reduces the risk of cardiac arrhythmias. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 23, 2023

2022 journal article

Corrigendum to ‘A collagen hydrogel loaded with HDAC7-derived peptide promotes the regeneration of infarcted myocardium with functional improvement in a rodent model’ [Acta Biomaterialia 2019, 86, 223-234] (Acta Biomaterialia (2019) 86 (223–234), (S174270611930042X), (10.1016/j.actbio.2019.01.022))

Acta Biomaterialia.

Contributors: Y. Zhang*, D. Zhu*, Y. Wei*, Y. Wu*, W. Cui*, L. Liuqin*, G. Fan*, Q. Yang* ...

Source: ORCID
Added: April 19, 2023

2022 article

Decoy Exosomes Offer Protection Against Chemotherapy-Induced Toxicity

Fan, M., Li, H., Shen, D., Wang, Z., Liu, H., Zhu, D., … Li, Z. (2022, September 4). ADVANCED SCIENCE, Vol. 9.

By: M. Fan*, H. Li*, D. Shen*, Z. Wang*, H. Liu*, D. Zhu n, Z. Wang n, L. Li* ...

author keywords: cardio-oncology; cardiotoxicity; chemotherapy; exosome; tetrahedral DNA nanostructure
MeSH headings : Humans; Exosomes / genetics; Exosomes / metabolism; Cardiotoxicity / etiology; Cardiotoxicity / prevention & control; Cardiotoxicity / metabolism; Quality of Life; Neoplasms; Antineoplastic Agents / toxicity; Antineoplastic Agents / metabolism; Chemical and Drug Induced Liver Injury / metabolism
TL;DR: This decoy exosome strategy serves as a promising therapy to reduce chemo‐induced toxicity and can also promote macrophage polarization into the M2 type for tissue repair. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 12, 2022

2022 article

Detachable Microneedle Patches Deliver Mesenchymal Stromal Cell Factor-Loaded Nanoparticles for Cardiac Repair

Hu, S., Zhu, D., Li, Z., & Cheng, K. (2022, September 23). ACS NANO, Vol. 9.

By: S. Hu n, D. Zhu n, Z. Li n & K. Cheng n

author keywords: mesenchymal stromal cell; secreted factors; microneedle patch; elastin-like peptide gel; hyaluronic acid gel; myocardial infarction; cardiac repair
MeSH headings : Animals; Rats; Elastin; Polylactic Acid-Polyglycolic Acid Copolymer; Hyaluronic Acid; Mesenchymal Stem Cells; Myocytes, Cardiac; Myocardium; Nanoparticles; Peptides
TL;DR: A detachable therapeutic microneedle patch, which is comprised of mesenchymal stromal cell-secreted factors (MSCF)-loaded poly(lactic-co-glycolic acid) nanoparticles (NP) in MN tips made of elastin-like polypeptide gel, provides a promising treatment approach for cardiac diseases. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 11, 2022

2022 article

Exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain as an inhalable COVID-19 vaccine

Wang, Z., Popowski, K. D., Zhu, D., Abad, B. L. de J., Wang, X., Liu, M., … Cheng, K. (2022, July 4). NATURE BIOMEDICAL ENGINEERING, Vol. 7.

By: Z. Wang n, K. Popowski n, D. Zhu n, B. Abad n, X. Wang n, M. Liu n, H. Lutz n, N. De Naeyer* ...

MeSH headings : Animals; Antibodies, Neutralizing; CD8-Positive T-Lymphocytes; COVID-19 / prevention & control; COVID-19 Vaccines; Exosomes; Humans; Mice; Mice, Inbred BALB C; SARS-CoV-2; Viral Vaccines
TL;DR: The design and preclinical testing of an inhalable virus-like-particle as a COVID-19 vaccine that, after lyophilisation, is stable at room temperature for over three months and elicits systemic and mucosal immune responses in small animals is reported. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 11, 2022

2022 journal article

Inhalable dry powder mRNA vaccines based on extracellular vesicles

Matter, 5(9), 2960–2974.

By: K. Popowski n, A. Moatti n, G. Scull n, D. Silkstone n, H. Lutz n, B. López de Juan Abad n, A. George n, E. Belcher n ...

TL;DR: The results suggest that extracellular vesicles can serve as an inhaled mRNA drug-delivery system that is superior to synthetic liposomes. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: October 17, 2022

2022 journal article

Intrapericardial Exosome Therapy Dampens Cardiac Injury via Activating Foxo3

CIRCULATION RESEARCH, 131(10), E135–E150.

By: D. Zhu n, S. Liu n, K. Huang n, Z. Wang n, S. Hu n, J. Li n, Z. Li n, K. Cheng n

author keywords: exosomes; immunomodulation; mesesnchymal stem cell; myocardial infarction; regulatory T cell
MeSH headings : Humans; Exosomes / metabolism; Forkhead Box Protein O3 / genetics; Forkhead Box Protein O3 / metabolism; Mesenchymal Stem Cells / metabolism; Myocardial Infarction / pathology; Proto-Oncogene Proteins c-akt / metabolism; Signal Transduction; Heart Injuries / metabolism
TL;DR: A novel mechanism underlying the immunomodulation effects of MSC exosomes is revealed and provides a promising candidate (PP2A/p-Akt/Foxo3 signaling pathway) with a favorable delivery route (intrapericardial injection) for cardiac repair. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 14, 2022

2022 journal article

Intrapericardial hydrogel injection generates high cell retention and augments therapeutic effects of mesenchymal stem cells in myocardial infarction

CHEMICAL ENGINEERING JOURNAL, 427.

By: J. Li n, Y. Lv*, D. Zhu n, X. Mei n, K. Huang n, X. Wang n, Z. Li n, S. Zhang n ...

Contributors: J. Li n, Y. Lv*, D. Zhu n, X. Mei n, K. Huang n, X. Wang n, Z. Li n, S. Zhang n ...

author keywords: Mesenchymal stem cells; Hydrogel; Myocardial infarction; Intrapericardial; Intramyocardial
TL;DR: Intrapericardial cavity injection gave a promising solution for the low retention issue of MSCs in the infarcted heart and the feasibility and safety of IPC injection were demonstrated in a porcine model with minimally invasive procedure. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 3, 2022

2022 journal article

Minimally invasive delivery of a hydrogel-based exosome patch to prevent heart failure

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 169, 113–121.

By: G. Cheng n, D. Zhu n, K. Huang n & T. Caranasos*

MeSH headings : Animals; Exosomes; Heart Failure; Hydrogels / therapeutic use; Myocardial Infarction / drug therapy; Myocardium; Rats; Swine
TL;DR: An injectable ExoGel was created and tested by embedding mesenchymal stem cell (MSC) -derived exosomes into hyaluronic acid (HA) hydrogel and injected into the pericardial cavity of rats with transverse aortic constriction induced heart failure, which reduced LV chamber size and preserved wall thickness. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 31, 2022

2022 journal article

Nanoparticles functionalized with stem cell secretome and CXCR4-overexpressing endothelial membrane for targeted osteoporosis therapy

JOURNAL OF NANOBIOTECHNOLOGY, 20(1).

By: C. Zhang*, W. Zhang*, D. Zhu n, Z. Li n, Z. Wang n, J. Li n, X. Mei n, W. Xu*, K. Cheng n, B. Zhong*

Contributors: C. Zhang*, W. Zhang*, D. Zhu n, Z. Li n, Z. Wang n, J. Li n, X. Mei n, W. Xu*, K. Cheng n, B. Zhong*

author keywords: Osteoporosis; CXCR4; Secretome; Mesenchymal stem cells; Bone targeting; Nanoparticles
MeSH headings : Animals; Cell Membrane / chemistry; Cell Membrane / metabolism; Disease Models, Animal; Endothelial Cells / chemistry; Endothelial Cells / metabolism; Mesenchymal Stem Cells / chemistry; Mesenchymal Stem Cells / metabolism; Nanoparticle Drug Delivery System; Nanoparticles; Osteoporosis / metabolism; Rats; Receptors, CXCR4 / metabolism; Secretome / metabolism
TL;DR: In a rat model of osteoporosis, MSC-Sec/CXCR4 NP were found to accumulate in bone, and such treatment inhibited osteoclast differentiation while promoting osteogenic proliferation. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 24, 2022

2021 journal article

A Minimally Invasive Exosome Spray Repairs Heart after Myocardial Infarction

ACS NANO, 15(7), 11099–11111.

By: J. Yao*, K. Huang n, D. Zhu n, T. Chen*, Y. Jiang*, J. Zhang*, L. Mi*, H. Xuan* ...

Contributors: J. Yao*, K. Huang n, D. Zhu n, T. Chen*, Y. Jiang*, J. Zhang*, L. Mi*, H. Xuan* ...

author keywords: MSC; exosome; spray; myocardial infarction; heart repair
MeSH headings : Mice; Swine; Animals; Exosomes; Myocardial Infarction / therapy; Mesenchymal Stem Cells; Heart; Disease Models, Animal
TL;DR: In a mouse model of acute myocardial infarction, EXOS improved cardiac function and reduced fibrosis, and promoted endogenous angiomyogenesis in the post-injury heart, indicating that EXOS is a promising strategy to deliver therapeutic exosomes for heart repair. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 23, 2021

2021 journal article

A fluid-powered refillable origami heart pouch for minimally invasive delivery of cell therapies in rats and pigs

MED, 2(11), 1253-+.

By: X. Mei n, D. Zhu n, J. Li n, K. Huang n, S. Hu n, Z. Li n, B. Abad n, K. Cheng n

Contributors: X. Mei n, D. Zhu n, J. Li n, K. Huang n, S. Hu n, Z. Li n, B. Juan Abad n, K. Cheng n

MeSH headings : Animals; Cell- and Tissue-Based Therapy; Heart; Mesenchymal Stem Cell Transplantation / methods; Mesenchymal Stem Cells; Myocardial Infarction / surgery; Rats; Swine
TL;DR: A fluid-driven heart pouch with a memory-shaped microfabricated lattice structure inspired by origami allowed minimally invasive delivery of the pouch to the heart with two small incisions and can be refilled multiple times with the therapeutic of choice. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 3, 2021

2021 journal article

A stem cell-derived ovarian regenerative patch restores ovarian function and rescues fertility in rats with primary ovarian insufficiency

THERANOSTICS, 11(18), 8894–8908.

By: S. Zhang n, D. Zhu n, Z. Li n, K. Huang n, S. Hu n, H. Lutz n, M. Xie n, X. Mei n ...

Contributors: S. Zhang n, D. Zhu n, Z. Li n, K. Huang n, S. Hu n, H. Lutz n, M. Xie n, X. Mei n ...

author keywords: primary ovarian insufficiency; ovarian regenerative patch; regenerative medicine; mesenchymal stem cells; acellular therapy; fertility
MeSH headings : Animals; Apoptosis; Cell-Derived Microparticles / metabolism; Disease Models, Animal; Female; Hydrogels / pharmacology; Infertility, Female / therapy; Mesenchymal Stem Cell Transplantation / methods; Mesenchymal Stem Cells / metabolism; Ovary / pathology; Primary Ovarian Insufficiency / therapy; Rats; Rats, Sprague-Dawley; Regenerative Medicine / methods; Secretome; Stem Cells / metabolism; Tissue Scaffolds
TL;DR: In a rat model of POI, implantation of ORP rescued fertility by restoring sexual hormone secretion, estrus cycle duration, and follicle development and represents a cell-free, off-the-shelf, and clinically feasible treatment for POI. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 12, 2021

2021 journal article

A trifunctional contraceptive gel enhances the safety and quality of sexual intercourse

BIOACTIVE MATERIALS, 6(6), 1777–1788.

By: M. Xie n, J. Li n, S. Zhang n, D. Zhu n, X. Mei n, Z. Wang n, X. Cheng n, Z. Li n, S. Wang*, K. Cheng n

Contributors: M. Xie n, J. Li n, S. Zhang n, D. Zhu n, X. Mei n, Z. Wang n, X. Cheng n, Z. Li n, S. Wang*, K. Cheng n

author keywords: Contraceptive; Hydrogel; Anti-viral; Libido; Erectile function
TL;DR: A novel TGN contraceptive gel consisting of three agents: tenofovir, gossypol acetate, and nitroglycerin (TGN) yielded a higher contraceptive success rate than that of the commercial contraceptive gel (Contragel®), and has the added benefits to prevent sexually transmitted diseases and improve male libido and erection function during sexual intercourse. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 6, 2021

2021 review

Advances in biomaterials and regenerative medicine for primary ovarian insufficiency therapy

[Review of ]. BIOACTIVE MATERIALS, 6(7), 1957–1972.

By: S. Zhang n, D. Zhu n, X. Mei n, Z. Li n, J. Li n, M. Xie n, H. Xie, S. Wang*, K. Cheng n

Contributors: S. Zhang n, D. Zhu n, X. Mei n, Z. Li n, J. Li n, M. Xie n, H. Xie, S. Wang*, K. Cheng n

author keywords: Stem cells; Primary ovarian insufficiency; Cell therapy; Biomaterials
TL;DR: A thorough understanding of the work already done can aid in the development of guidelines for future translational applications and clinical trials that aim to cure POI by using regenerative medicine and biomedical engineering strategies. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 6, 2021

2021 review

All Roads Lead to Rome (the Heart): Cell Retention and Outcomes From Various Delivery Routes of Cell Therapy Products to the Heart

[Review of ]. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 10(8).

By: J. Li n, S. Hu n, D. Zhu n, K. Huang n, X. Mei n, B. Abad n, K. Cheng n

Contributors: J. Li n, S. Hu n, D. Zhu n, K. Huang n, X. Mei n, B. Abad n, K. Cheng n

author keywords: cardiac repair; cell delivery; intracoronary; intramyocardial; intrapericardial; intravenous; retention rate
MeSH headings : Animals; Cell- and Tissue-Based Therapy / methods; Heart Diseases / therapy; Humans; Injections
TL;DR: An in‐depth study of primary theories of cell loss, including low efficiency in cell injection, “washout” effects, and cell death, is undertaken and the literature from the past decade that focuses on cell transplantation to the heart using various cell delivery routes is organized. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 10, 2021

2021 journal article

Bioengineering Technologies for Cardiac Regenerative Medicine

Frontiers in Bioengineering and Biotechnology, 9.

By: M. Chingale n, D. Zhu n, K. Cheng n & K. Huang

Contributors: M. Chingale n, D. Zhu n, K. Cheng n & K. Huang

author keywords: bioengineering; cardiac repair; cell reprogramming; exosome; cardiac patch; targeting
TL;DR: Recent advancements in bioengineering and biotechnologies for cardiac regenerative medicine are discussed, including protein decoration, antibody modification, and platelet membranes have been used for targeting and precision medicine. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: June 28, 2021

2021 journal article

Bispecific Antibody Inhalation Therapy for Redirecting Stem Cells from the Lungs to Repair Heart Injury

Advanced Science, 8(1).

TL;DR: This work demonstrates that this novel inhalable antibody therapy, which harnesses platelets derived from the lungs, contributes to potent stem cell redirection and heart repair. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: ORCID
Added: April 19, 2023

2021 review

Cardiac Cell Therapy for Heart Repair: Should the Cells Be Left Out?

[Review of ]. CELLS, 10(3).

By: D. Zhu n & K. Cheng n

Contributors: D. Zhu n & K. Cheng n

author keywords: stem cell; myocardial infarction; cardiovascular diseases; acellular therapy; exosomes; paracrine effects; biomedical engineering; biomaterials
MeSH headings : Cell- and Tissue-Based Therapy / methods; Heart Failure / pathology; Heart Failure / therapy; Humans; Myocardium / pathology; Myocytes, Cardiac / metabolism; Tissue Engineering / methods
TL;DR: Current therapeutic approaches for cardiac repair are summarized and discussed and a perspective on novel strategies that holding potential opportunities for future research and clinical translation are provided. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 15, 2021

2021 journal article

Cell-mimicking nanodecoys neutralize SARS-CoV-2 and mitigate lung injury in a non-human primate model of COVID-19

Nature Nanotechnology, 6(8), 942–951.

By: Z. Li n, Z. Wang n, P. Dinh n, D. Zhu n, K. Popowski n, H. Lutz n, S. Hu n, M. Lewis* ...

Contributors: Z. Li n, Z. Wang n, P. Dinh n, D. Zhu n, K. Popowski n, H. Lutz n, S. Hu n, M. Lewis* ...

MeSH headings : Administration, Inhalation; Angiotensin-Converting Enzyme 2 / metabolism; Animals; COVID-19 / virology; Cell-Derived Microparticles / metabolism; Cell-Derived Microparticles / transplantation; Disease Models, Animal; Humans; Lung Injury / prevention & control; Lung Injury / virology; Macaca fascicularis; Mice; Nanostructures / administration & dosage; Protein Binding; SARS-CoV-2 / drug effects; SARS-CoV-2 / metabolism; Spheroids, Cellular / metabolism; Spike Glycoprotein, Coronavirus / metabolism; Viral Load / drug effects; COVID-19 Drug Treatment
TL;DR: It is shown that nanovesicles coated with lung spheroid cell membranes expressing angiotensin-converting enzyme 2 can bind the spike protein of SARS-CoV-2, neutralizing the virus and preventing lung cell infections in murine and non-human primate models. (via Semantic Scholar)
Source: ORCID
Added: June 18, 2021

2021 journal article

Exosome-eluting stents for vascular healing after ischaemic injury

NATURE BIOMEDICAL ENGINEERING, 5(10), 1174–1188.

By: S. Hu n, Z. Li n, D. Shen n, D. Zhu n, K. Huang n, T. Su n, P. Dinh n, J. Cores n, K. Cheng n

Contributors: S. Hu n, Z. Li n, D. Shen n, D. Zhu n, K. Huang n, T. Su n, P. Dinh n, J. Cores n, K. Cheng n

MeSH headings : Animals; Drug-Eluting Stents; Endothelial Cells; Endothelium, Vascular; Exosomes; Ischemia; Rats; Stents
TL;DR: It is shown that stents releasing exosomes derived from mesenchymal stem cells in the presence of reactive oxygen species enhance vascular healing in rats with renal ischaemia-reperfusion injury, promoting endothelial cell tube formation and proliferation, and impairing the migration of smooth muscle cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: April 6, 2021

2021 journal article

Extruded Mesenchymal Stem Cell Nanovesicles Are Equally Potent to Natural Extracellular Vesicles in Cardiac Repair

ACS APPLIED MATERIALS & INTERFACES, 13(47), 55767–55779.

By: X. Wang n, S. Hu n, J. Li n, D. Zhu n, Z. Wang n, J. Cores n, K. Cheng n, G. Liu*, K. Huang n

Contributors: X. Wang n, S. Hu n, J. Li n, D. Zhu n, Z. Wang n, J. Cores n, K. Cheng n, G. Liu*, K. Huang n

author keywords: extrusion; nanovesicles; extracellular vesicles; mesenchymal stem cell; ischemia reperfusion injury
MeSH headings : Animals; Disease Models, Animal; Endothelial Cells / drug effects; Endothelial Cells / pathology; Extracellular Vesicles / chemistry; Fibroblasts / drug effects; Fibroblasts / pathology; Mesenchymal Stem Cells / chemistry; Mesenchymal Stem Cells / cytology; Mice; Myocardial Infarction / drug therapy; Myocardial Infarction / pathology; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / pathology; Nanoparticles / chemistry; Particle Size; Surface Properties
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 21, 2022

2021 journal article

Injection of ROS-Responsive Hydrogel Loaded with Basic Fibroblast Growth Factor into the Pericardial Cavity for Heart Repair

ADVANCED FUNCTIONAL MATERIALS, 31(15).

By: Z. Li n, D. Zhu n, Q. Hui*, J. Bi*, B. Yu*, Z. Huang*, S. Hu n, Z. Wang n ...

Contributors: Z. Li n, D. Zhu n, Q. Hui*, J. Bi*, B. Yu*, Z. Huang*, S. Hu n, Z. Wang n ...

author keywords: bFGF; heart repair; intrapericardial delivery; pericardial cavity; ROS responsive hydrogels
TL;DR: A ROS‐sensitive cross‐linked poly(vinyl alcohol) (PVA) hydrogel is synthesized to deliver basic fibroblast growth factor (bFGF) for myocardial repair and protects cardiac function and reduces fibrosis in the post‐I/R heart, with enhanced angiomyogenesis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 22, 2021

2021 journal article

Minimally invasive delivery of therapeutic agents by hydrogel injection into the pericardial cavity for cardiac repair

NATURE COMMUNICATIONS, 12(1).

By: D. Zhu n, Z. Li n, K. Huang n, T. Caranasos*, J. Rossi* & K. Cheng n

Contributors: D. Zhu n, Z. Li n, K. Huang n, T. Caranasos*, J. Rossi* & K. Cheng n

MeSH headings : Animals; Cardiac Surgical Procedures; Cardiovascular Agents / administration & dosage; Cell Differentiation / physiology; Drug Delivery Systems / methods; Exosomes / metabolism; Extracellular Matrix / chemistry; Hydrogels / administration & dosage; Hydrogels / chemistry; Induced Pluripotent Stem Cells / transplantation; Male; Materials Testing; Mesenchymal Stem Cells / cytology; Mice; Minimally Invasive Surgical Procedures / methods; Myocardial Infarction / drug therapy; Myocardial Infarction / pathology; Myocardial Infarction / therapy; Myocytes, Cardiac / cytology; Myocytes, Cardiac / physiology; Pericardium; Rats; Swine
TL;DR: In rodent models of myocardial infarction, it is demonstrated that intrapericardial injection is an effective and safe method to deliver hydrogels containing induced pluripotent stem cells-derived cardiac progenitor cells or mesenchymal stem Cells-derived exosomes. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 6, 2021

2021 journal article

Nitrate-functionalized patch confers cardioprotection and improves heart repair after myocardial infarction via local nitric oxide delivery

Nature Communications, 12(1).

Contributors: D. Zhu*, J. Hou*, M. Qian*, D. Jin*, T. Hao*, Y. Pan*, H. Wang*, S. Wu* ...

MeSH headings : Animals; Cardiotonic Agents / metabolism; Cardiotonic Agents / pharmacology; Disease Models, Animal; Drug Implants / metabolism; Drug Implants / pharmacology; Heart / drug effects; Heart / physiopathology; Macrophage Activation / drug effects; Male; Mice; Myocardial Infarction / metabolism; Myocardial Infarction / mortality; Myocardial Infarction / prevention & control; Myocardial Ischemia / metabolism; Myocardial Ischemia / prevention & control; Myocardial Reperfusion Injury / metabolism; Myocardial Reperfusion Injury / prevention & control; Nitrates / metabolism; Nitrogen Oxides / metabolism; RAW 264.7 Cells; Rats, Sprague-Dawley; Survival Rate; Swine
TL;DR: A cardiac patch with NO releasing function that favors heart repair after myocardial infarction is developed, which supports the translational potential of this functional patch for treating ischemic heart disease by therapeutic mechanisms different from conventional organic nitrate drugs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: July 24, 2021

2021 journal article

Platelet membrane and stem cell exosome hybrids enhance cellular uptake and targeting to heart injury

NANO TODAY, 39.

By: S. Hu n, X. Wang n, Z. Li n, D. Zhu n, J. Cores n, Z. Wang n, J. Li n, X. Mei n ...

Contributors: S. Hu n, X. Wang n, Z. Li n, D. Zhu n, J. Cores n, Z. Wang n, J. Li n, X. Mei n ...

author keywords: Exosomes; Targeting; Myocardial infarction; Platelet membrane; Stem cells
TL;DR: It is found that encapsulation by the platelet membranes induces macropinocytosis, enhancing the cellular uptake of exosomes by endothelial cells and cardiomyocytes strikingly and boosting the cardiac targeting ability of hybrid exosome in a mice model with myocardial infarction injury. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 7, 2021

2021 journal article

Publisher Correction: Exosome-eluting stents for vascular healing after ischaemic injury

Nature Biomedical Engineering, 5(10), 1239.

Contributors: S. Hu n, Z. Li n, D. Shen n, D. Zhu n, K. Huang n, T. Su n, P. Dinh n, J. Cores n, K. Cheng n

Source: ORCID
Added: April 21, 2021

2020 journal article

Anti-neuroinflammatory effects of dimethylaminomylide (DMAMCL, i.e., ACT001) are associated with attenuating the NLRP3 inflammasome in MPTP-induced Parkinson disease in mice

Behavioural Brain Research, 383.

By: Q. Liu*, X. Guo*, Z. Huang*, Q. He*, D. Zhu*, S. Zhang*, Z. Peng*, Y. Che*, X. Feng

Contributors: Q. Liu*, X. Guo*, Z. Huang*, Q. He*, D. Zhu*, S. Zhang*, Z. Peng*, Y. Che*, X. Feng

MeSH headings : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Behavior, Animal / drug effects; Catalase / drug effects; Catalase / metabolism; Circadian Rhythm / drug effects; Corpus Striatum / drug effects; Corpus Striatum / metabolism; Corpus Striatum / pathology; Cytokines / drug effects; Cytokines / metabolism; Dopaminergic Neurons / drug effects; Dopaminergic Neurons / metabolism; Dopaminergic Neurons / pathology; Inflammasomes / drug effects; Inflammasomes / metabolism; Inflammation / metabolism; Inflammation / physiopathology; Malondialdehyde / metabolism; Mice; NLR Family, Pyrin Domain-Containing 3 Protein / drug effects; NLR Family, Pyrin Domain-Containing 3 Protein / metabolism; Oxidative Stress / drug effects; Parkinsonian Disorders / metabolism; Parkinsonian Disorders / physiopathology; Sesquiterpenes, Guaiane / pharmacology; Substantia Nigra / drug effects; Substantia Nigra / metabolism; Substantia Nigra / pathology; Superoxide Dismutase / drug effects; Superoxide Dismutase / metabolism; Tyrosine 3-Monooxygenase / metabolism
TL;DR: The study showed that ACT001 alleviates NLRP3-mediated neuroinflammation in PD mice induced by MPTP, and attenuates microglial activation in the nigrostriatal pathway. (via Semantic Scholar)
Source: ORCID
Added: April 19, 2023

2020 journal article

Delivery of mscs with a hybrid β-sheet peptide hydrogel consisting igf-1c domain and d-form peptide for acute kidney injury therapy

International Journal of Nanomedicine, 15, 4311–4324.

By: H. Wang*, Y. Shang*, X. Chen*, Z. Wang*, D. Zhu*, Y. Liu*, C. Zhang*, P. Chen* ...

Contributors: H. Wang*, Y. Shang*, X. Chen*, Z. Wang*, D. Zhu*, Y. Liu*, C. Zhang*, P. Chen* ...

MeSH headings : Acute Kidney Injury / drug therapy; Acute Kidney Injury / physiopathology; Animals; Biocompatible Materials / chemistry; Cell Survival; Female; Fibrosis; Human Umbilical Vein Endothelial Cells / metabolism; Humans; Hydrogels / chemical synthesis; Hydrogels / chemistry; Insulin-Like Growth Factor I / chemistry; Kidney / pathology; Kidney / physiopathology; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells / cytology; Mice, Transgenic; Neovascularization, Physiologic; Peptides / chemistry; Placenta / cytology; Pregnancy; Protein Conformation, beta-Strand; Protein Domains
TL;DR: By covalently linking the desired functional groups to D-form peptides to create functional hydrogels, self-assembling β-sheet peptidehydrogels may serve as a promising platform for tissue-engineering and stem cell therapy. (via Semantic Scholar)
Source: ORCID
Added: April 19, 2023

2020 journal article

Effects of 17β-trenbolone exposure on sex hormone synthesis and social behaviours in adolescent mice

Chemosphere, 245.

By: S. Zhang*, S. Zhang*, D. Zhu*, Z. Jiao*, X. Zhao*, M. Sun*, Y. Che*, X. Feng*

Contributors: S. Zhang*, S. Zhang*, D. Zhu*, Z. Jiao*, X. Zhao*, M. Sun*, Y. Che*, X. Feng*

MeSH headings : Animals; Anxiety / chemically induced; Avoidance Learning / drug effects; Endocrine Disruptors / pharmacology; Gonadal Steroid Hormones / biosynthesis; Male; Mice; Myelin Sheath / drug effects; Oligodendroglia / drug effects; Social Behavior; Trenbolone Acetate / pharmacology
TL;DR: Exposure to 17β-TBOH during puberty increased anxiety-like behaviours and affected testicular development and endogenous androgen synthesis in male mice, and the inhibition of the secretion of endogenous hormones and decrease in the formation of the myelin sheath in mPFC may be associated with the 17 β-T BOH-induced behavioural changes in mice. (via Semantic Scholar)
Source: ORCID
Added: April 19, 2023

2020 journal article

Light-triggered NO-releasing nanoparticles for treating mice with liver fibrosis

NANO RESEARCH, 13(8), 2197–2202.

By: H. Liang*, Z. Li n, Z. Ren*, Q. Jia*, L. Guo*, S. Li*, H. Zhang*, S. Hu n ...

Contributors: H. Liang*, Z. Li n, Z. Ren*, Q. Jia*, L. Guo*, S. Li*, H. Zhang*, S. Hu n ...

author keywords: liver fibrosis; nitric oxide (NO); hepatic stellate cells (HSC); nanoparticles; near infrared light (NIR)-controlled release
TL;DR: A targeted and controlled release method that triggers HSC apoptosis and reverses the liver fibrosis is provided the theoretical and experimental basis for novel therapeutic approaches to treat hepatic fibrosis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 29, 2020

2020 journal article

Multifunctional natural polymer nanoparticles as antifibrotic gene carriers for CKD therapy

Journal of the American Society of Nephrology, 31(10), 2292–2311.

Contributors: A. Midgley*, Y. Wei*, D. Zhu*, F. Gao*, H. Yan*, A. Khalique*, W. Luo*, H. Jiang* ...

MeSH headings : Animals; Antifibrinolytic Agents / administration & dosage; Bone Morphogenetic Protein 7 / genetics; Cell Culture Techniques; Chitosan; Disease Models, Animal; Gene Transfer Techniques; Hepatocyte Growth Factor / genetics; Hyaluronic Acid; Mice; Multifunctional Nanoparticles; Polymers; Renal Insufficiency, Chronic / therapy
TL;DR: Nanoparticle delivery of HGF/NK1 conveyed potent antifibrotic and proregenerative effects in vivo and provided the proof of concept on which to base future investigations for enhanced targeting and transfection of therapeutic genes to kidney tissues, and an avenue toward treatment of CKD. (via Semantic Scholar)
Source: ORCID
Added: April 19, 2023

2020 journal article

Particle-based artificial three-dimensional stem cell spheroids for revascularization of ischemic diseases

Science Advances, 6(19).

TL;DR: A particle-based artificial stem cell spheroid (ASSP) technology is introduced that recapitulates paracrine functions of three-dimensional (3D) SSPs for vasculature regeneration and addresses issues faced by the bottlenecked development in the delivery of stem cell therapies. (via Semantic Scholar)
Source: ORCID
Added: March 6, 2021

2020 journal article

Supramolecular Nanofibers Containing Arginine-Glycine-Aspartate (RGD) Peptides Boost Therapeutic Efficacy of Extracellular Vesicles in Kidney Repair

ACS Nano, 14(9), 12133–12147.

MeSH headings : Animals; Arginine; Aspartic Acid; Extracellular Vesicles; Glycine; Kidney; Mice; Nanofibers; Oligopeptides
TL;DR: An RGD-scaffold was developed to increase the EV integrin-mediated loading and in-turn improved therapeutic efficacy in renal repair, therefore this strategy shed light on MSC-EVs application as cell-free treatment for potentiated efficiency. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: April 19, 2023

2020 journal article

Targeted Repair of Vascular Injury by Adipose-Derived Stem Cells Modified with P-Selectin Binding Peptide

Advanced Science, 7(11).

By: H. Yan*, X. Mi*, A. Midgley*, X. Du*, Z. Huang*, T. Wei*, R. Liu*, T. Ma* ...

Contributors: H. Yan*, X. Mi*, A. Midgley*, X. Du*, Z. Huang*, T. Wei*, R. Liu*, T. Ma* ...

TL;DR: Overall, DPP‐ADSCs promote vascular repair, inhibit neointimal hyperplasia, increase endothelium functionality, and maintain normal VSMCs alignment, supporting preclinical noninvasive utilization of D PP‐AD SCs for vascular injury. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: April 19, 2023

2020 journal article

The parthenolide derivative ACT001 synergizes with low doses of L-DOPA to improve MPTP-induced Parkinson's disease in mice

Behavioural Brain Research, 379.

By: Q. Liu*, S. Zhang*, D. Zhu*, X. Tang*, Y. Che* & X. Feng

Contributors: Q. Liu*, S. Zhang*, D. Zhu*, X. Tang*, Y. Che* & X. Feng

MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Antiparkinson Agents / administration & dosage; Antiparkinson Agents / pharmacology; Apoptosis / drug effects; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Female; Inflammation / drug therapy; Levodopa; Male; Mice; Mice, Inbred BALB C; Nerve Degeneration / drug therapy; Parkinson Disease / drug therapy; Parkinsonian Disorders / drug therapy; Sesquiterpenes / administration & dosage; Sesquiterpenes / analysis; Sesquiterpenes / pharmacology
TL;DR: The effects of the co-administration of ACT001 and l-DOPA were equivalent to those of the administration of 8 mg/kg l-dOPA in MPTP-induced Parkinson's disease in mice, suggesting that l- DOPA + ACT001 may be used for the treatment of PD. (via Semantic Scholar)
Source: ORCID
Added: April 19, 2023

2019 journal article

A collagen hydrogel loaded with HDAC7-derived peptide promotes the regeneration of infarcted myocardium with functional improvement in a rodent model

Acta Biomaterialia, 86, 223–234.

Contributors: Y. Zhang*, D. Zhu*, Y. Wei*, Y. Wu*, W. Cui*, L. Liuqin*, G. Fan*, Q. Yang* ...

MeSH headings : Animals; Apoptosis / drug effects; Cell Differentiation / drug effects; Cell Survival / drug effects; Collagen / pharmacology; Culture Media, Serum-Free; Disease Models, Animal; Female; Histone Deacetylases / chemistry; Hydrogels / pharmacology; Mice, Inbred C57BL; Myocardial Infarction / physiopathology; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / pathology; Neovascularization, Physiologic / drug effects; Peptides / pharmacology; Rats; Recovery of Function / drug effects; Regeneration / drug effects; Stem Cells / cytology; Stem Cells / drug effects; Ventricular Function / drug effects
TL;DR: In vivo investigations in a mouse MI model demonstrated that intra-myocardial delivery of 7Ap-loaded collagen hydrogel promoted neovascularization, stimulated Sca-l+ stem cell recruitment and differentiation, reduced cardiomyocyte apoptosis and promoted cell cycle progression, and 7Ap was shown to improve H9C2 cell survival, in vitro. (via Semantic Scholar)
Source: ORCID
Added: April 19, 2023

2019 article

Delivery of MSCs with a Hybrid β-Sheet Peptide Hydrogel Consisting IGF-1C Domain and D-Form Peptide for Acute Kidney Injury Therapy

SSRN.

By: H. Wang*, Y. Shang*, X. Chen*, Z. Wang*, D. Zhu*, Y. Liu*, C. Zhang*, P. Chen* ...

Contributors: H. Wang*, Y. Shang*, X. Chen*, Z. Wang*, D. Zhu*, Y. Liu*, C. Zhang*, P. Chen* ...

Source: ORCID
Added: April 19, 2023

2019 journal article

Lactobacillus maintains healthy gut mucosa by producing L-Ornithine

Communications Biology, 2(1).

By: H. Qi*, Y. Li*, H. Yun*, T. Zhang*, Y. Huang*, J. Zhou*, H. Yan*, J. Wei* ...

Contributors: H. Qi*, Y. Li*, H. Yun*, T. Zhang*, Y. Huang*, J. Zhou*, H. Yan*, J. Wei* ...

MeSH headings : Animals; Basic Helix-Loop-Helix Transcription Factors / metabolism; Epithelial Cells / immunology; Epithelial Cells / metabolism; Epithelial Cells / microbiology; Female; Gastrointestinal Microbiome / immunology; Gastrointestinal Microbiome / physiology; Germ-Free Life; Homeostasis; Humans; Intestinal Mucosa / immunology; Intestinal Mucosa / metabolism; Intestinal Mucosa / microbiology; Lactobacillus / immunology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Mucus / metabolism; Nuclear Receptor Subfamily 1, Group F, Member 3 / metabolism; Ornithine / biosynthesis; Pancreatitis-Associated Proteins / genetics; Pancreatitis-Associated Proteins / metabolism; Receptors, Aryl Hydrocarbon / metabolism
TL;DR: It is shown that lactobacilli promote the generation of gut mucosa by facilitating the conversion of arginine to L-Ornithine, and implicates the importance of a crosstalk betweenArginine metabolism in LactOBacilli and tryptophan metabolism in gut epithelial cells in maintaining a healthy gut barrier. (via Semantic Scholar)
Source: ORCID
Added: April 19, 2023

2019 journal article

Preparation of levodopa-loaded crystalsomes through thermally induced crystallization reverses functional deficits in Parkinsonian mice

Biomaterials Science, 7(4), 1623–1631.

By: X. Li*, Q. Liu*, D. Zhu*, Y. Che* & X. Feng

Contributors: X. Li*, Q. Liu*, D. Zhu*, Y. Che* & X. Feng

MeSH headings : Animals; Antiparkinson Agents / chemical synthesis; Antiparkinson Agents / chemistry; Antiparkinson Agents / therapeutic use; Crystallization; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Carriers / chemistry; Emulsions / chemical synthesis; Emulsions / chemistry; Emulsions / therapeutic use; Female; Levodopa / chemical synthesis; Levodopa / chemistry; Levodopa / therapeutic use; Mice; Mice, Inbred BALB C; Molecular Structure; Nanoparticles / chemistry; Parkinson Disease / drug therapy; Structure-Activity Relationship; Temperature
TL;DR: Levodopa-loaded crystallization nanoparticles (LD crystalsomes) were prepared by a mini-emulsion crystallization method and exhibited a positive zeta potential, nanoscale range and longer releasing time for levodopa (LD). (via Semantic Scholar)
Source: ORCID
Added: April 19, 2023

2019 journal article

Resveratrol synergizes with low doses of L-DOPA to improve MPTP-induced Parkinson disease in mice

Behavioural Brain Research, 367, 10–18.

By: Q. Liu*, D. Zhu*, P. Jiang*, X. Tang*, Q. Lang*, Q. Yu*, S. Zhang*, Y. Che*, X. Feng*

Contributors: Q. Liu*, D. Zhu*, P. Jiang*, X. Tang*, Q. Lang*, Q. Yu*, S. Zhang*, Y. Che*, X. Feng*

MeSH headings : Animals; Antioxidants / administration & dosage; Antioxidants / pharmacology; Antiparkinson Agents / administration & dosage; Antiparkinson Agents / pharmacology; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Female; Levodopa / administration & dosage; Levodopa / pharmacology; MPTP Poisoning / drug therapy; Mice; Mice, Inbred BALB C; Resveratrol / administration & dosage; Resveratrol / pharmacology
TL;DR: RV significantly reduced motor dysfunction in MPTP‐treated mice, and the RV‐treated group showed less IL‐1&bgr; and an enhanced pAkt/Akt ratio, which promoted dopamine neuron survival in the striatum. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: April 19, 2023

2019 journal article

Targeted delivery of nitric oxide via a ‘bump-and-hole’-based enzyme–prodrug pair

Nature Chemical Biology, 15(2), 151–160.

Contributors: J. Hou*, Y. Pan*, D. Zhu*, Y. Fan*, G. Feng*, Y. Wei*, H. Wang*, K. Qin* ...

MeSH headings : Animals; Azo Compounds; Drug Delivery Systems / methods; Galactosidases; Male; Mice; Mice, Inbred C57BL; Mice, Nude; Nitric Oxide / administration & dosage; Nitric Oxide / metabolism; Nitric Oxide / physiology; Prodrugs; Rats; Rats, Sprague-Dawley; beta-Galactosidase / metabolism; beta-Galactosidase / physiology
TL;DR: A novel NO delivery system that depends on the hydrolysis of an alkyl-galactose-conjugated NO prodrug by an engineered galactosidase developed using a ‘bump-and-hole’ strategy enabled targeted delivery of NO to specific tissues. (via Semantic Scholar)
Source: ORCID
Added: April 19, 2023

2018 journal article

Expression and clinical significance of CXC-chemokine ligand 5 in renal cell carcinoma

Chinese Journal of Clinical Oncology, 45(16), 838–843.

By: G. Feng*, H. Li*, D. Zhu*, Y. Zhang*, G. Song*, Z. Zhang*, M. Chen*, J. Du*, X. Yao

Contributors: G. Feng*, H. Li*, D. Zhu*, Y. Zhang*, G. Song*, Z. Zhang*, M. Chen*, J. Du*, X. Yao

Source: ORCID
Added: April 19, 2023

2018 journal article

In situ cardiac regeneration by using neuropeptide substance P and IGF-1C peptide eluting heart patches

Regenerative Biomaterials, 5(5), 303–316.

TL;DR: Data suggest that SP and IGF-1C peptides may act synergistically for in situ tissue repair in cardiac patches developed to develop cardiac patches capable of simultaneously eluting substance P (SP) and insulin-like growth factor- 1C (IGF-1 C) peptide. (via Semantic Scholar)
Source: ORCID
Added: April 19, 2023

2018 journal article

Prostaglandin E<sub>2</sub> hydrogel improves cutaneous wound healing via M2 macrophages polarization

Theranostics, 8(19), 5348–5361.

By: S. Zhang*, Y. Liu*, X. Zhang*, D. Zhu*, X. Qi*, X. Cao*, Y. Fang*, Y. Che* ...

Contributors: S. Zhang*, Y. Liu*, X. Zhang*, D. Zhu*, X. Qi*, X. Cao*, Y. Fang*, Y. Che* ...

MeSH headings : Animals; Cells, Cultured; Chitosan / administration & dosage; Dinoprostone / administration & dosage; Disease Models, Animal; Drug Carriers / administration & dosage; Hydrogel, Polyethylene Glycol Dimethacrylate / administration & dosage; Immunologic Factors / administration & dosage; Inflammation / pathology; Luminescent Measurements; Macrophage Activation / drug effects; Macrophages, Peritoneal / drug effects; Macrophages, Peritoneal / immunology; Mice; Molecular Imaging; Neovascularization, Physiologic / drug effects; Treatment Outcome; Wound Healing / drug effects; Wounds and Injuries / therapy
TL;DR: Molecular imaging results showed that the prolonged release of PGE2 could ameliorate inflammation by promoting the M2 phenotypic transformation of macrophages and highlighted the potential of CS+PGE2 hydrogel as a novel therapeutic strategy for promoting tissue regeneration via M2 macrophage polarization. (via Semantic Scholar)
Source: ORCID
Added: April 19, 2023

2017 journal article

Herbal formula Xian-Fang-Huo-Ming-Yin regulates differentiation of lymphocytes and production of pro-inflammatory cytokines in collagen-induced arthritis mice

BMC Complementary and Alternative Medicine, 17(1).

By: J. Li*, Y. Wei*, X. Li*, D. Zhu*, B. Nie*, J. Zhou*, L. Lou*, B. Dong* ...

Contributors: J. Li*, Y. Wei*, X. Li*, D. Zhu*, B. Nie*, J. Zhou*, L. Lou*, B. Dong* ...

MeSH headings : Animals; Arthritis / drug therapy; Arthritis / genetics; Arthritis / immunology; Arthritis / physiopathology; Cell Differentiation; Collagen / adverse effects; Cytokines / genetics; Cytokines / immunology; Disease Models, Animal; Drugs, Chinese Herbal / administration & dosage; Humans; Janus Kinases / genetics; Janus Kinases / immunology; Lymphocytes / cytology; Lymphocytes / immunology; Male; Mice; Mice, Inbred DBA; NF-kappa B / genetics; NF-kappa B / immunology
TL;DR: XFHM can regulate and maintain the immunologic balance of lymphocytic immunity and inhibit the production of pro-inflammatory cytokines, thus suppressing the pathological changes of RA, and may be used as an application of traditional medicine against RA in modern complementary and alternative therapeutics. (via Semantic Scholar)
Source: ORCID
Added: April 19, 2023

2017 journal article

PEGylation corannulene enhances response of stress through promoting neurogenesis

Biomaterials Science, 5(4), 849–859.

By: X. Li*, D. Sun*, X. Li*, D. Zhu*, Z. Jia*, J. Jiao*, K. Wang*, D. Kong* ...

Contributors: X. Li*, D. Sun*, X. Li*, D. Zhu*, Z. Jia*, J. Jiao*, K. Wang*, D. Kong* ...

MeSH headings : Animals; Doublecortin Protein; Female; Locomotion / drug effects; Mice; Mice, Inbred BALB C; Nanoparticles / chemistry; Nanoparticles / ultrastructure; Neurogenesis / drug effects; Polycyclic Aromatic Hydrocarbons / chemistry; Polycyclic Aromatic Hydrocarbons / pharmacology; Polyethylene Glycols / chemistry; Polyethylene Glycols / pharmacology; Stress, Physiological / drug effects
TL;DR: It is found that PEGylation CoNps administration enhanced TH, DCX and MAP-2 expression in the hippocampus, indicating that P EGylation coNps enhanced the neurogenesis of mice. (via Semantic Scholar)
Source: ORCID
Added: April 19, 2023

2017 journal article

Puerarin and Amlodipine Improvement of d-Galactose-Induced Impairments of Behaviour and Neurogenesis in Mouse Dentate Gyrus: Correlation with Glucocorticoid Receptor Expression

Neurochemical Research, 42(11), 3268–3278.

By: X. Li*, J. Ma*, J. Xu*, D. Zhu*, A. Li*, Y. Che*, D. Chen*, X. Feng*

Contributors: X. Li*, J. Ma*, J. Xu*, D. Zhu*, A. Li*, Y. Che*, D. Chen*, X. Feng*

MeSH headings : Aging / drug effects; Aging / metabolism; Aging / pathology; Amlodipine / administration & dosage; Animals; Dentate Gyrus / drug effects; Dentate Gyrus / metabolism; Dentate Gyrus / pathology; Doublecortin Protein; Drug Therapy, Combination; Female; Galactose / toxicity; Gene Expression; Isoflavones / administration & dosage; Maze Learning / drug effects; Maze Learning / physiology; Mice; Mice, Inbred BALB C; Neurogenesis / drug effects; Neurogenesis / physiology; Receptors, Glucocorticoid / biosynthesis; Receptors, Glucocorticoid / genetics; Vasodilator Agents / administration & dosage
TL;DR: Results suggest that AM and PU could improve d-gal-induced behavioural deficits in correlation with GR gene expression, and suggest that hypotensors, which have effects on improving vascular dysfunction, may be able to ameliorate GR gene Expression decline in ageing mice and improve ageing-mediated memory deficits. (via Semantic Scholar)
Source: ORCID
Added: April 19, 2023

2017 journal article

Rhein and polydimethylsiloxane functionalized carbon/carbon composites as prosthetic implants for bone repair applications

Biomedical Materials (Bristol), 12(4).

By: Z. Jia*, C. Yang*, J. Jiao*, X. Li*, D. Zhu*, Y. Yang*, J. Yang*, Y. Che*, Y. Lu*, X. Feng

Contributors: Z. Jia*, C. Yang*, J. Jiao*, X. Li*, D. Zhu*, Y. Yang*, J. Yang*, Y. Che*, Y. Lu*, X. Feng

MeSH headings : Anthraquinones / chemistry; Anthraquinones / metabolism; Biocompatible Materials / chemistry; Bone and Bones / chemistry; Bone and Bones / physiology; Cell Adhesion; Dimethylpolysiloxanes / chemistry; Nanotubes, Carbon / chemistry; Prostheses and Implants; Tissue Engineering / methods
TL;DR: In vivo, x-ray and micro-CT evaluation three, six and nine weeks after surgery revealed that rhein–PDMS–C/C was more effective than PDMS–B/C and C/C composite in terms of antibacterial activity, cell adhesion and tissue growth. (via Semantic Scholar)
Source: ORCID
Added: April 19, 2023

2016 journal article

IGF-1 C domain-modified hydrogel enhances cell therapy for AKI

Journal of the American Society of Nephrology, 27(8), 2357–2369.

By: G. Feng*, J. Zhang*, Y. Li, Y. Nie, D. Zhu*, R. Wang, J. Liu*, J. Gao* ...

Contributors: G. Feng*, J. Zhang*, Y. Li, Y. Nie, D. Zhu*, R. Wang, J. Liu*, J. Gao* ...

MeSH headings : Acute Kidney Injury / therapy; Adipose Tissue / cytology; Animals; Chitosan; Combined Modality Therapy; Hydrogel, Polyethylene Glycol Dimethacrylate; Insulin-Like Growth Factor I / administration & dosage; Mesenchymal Stem Cell Transplantation; Mice
TL;DR: In conclusion, IGF-1C immobilized on a chitosan hydrogel provides an artificial microenvironment for ADSCs and may be a promising therapeutic approach for AKI. (via Semantic Scholar)
Source: ORCID
Added: April 19, 2023

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