@article{nguyen_blackledge_lindsey_minrovic_ackart_jeon_obregon-henao_melander_basaraba_melander_2017, title={The Discovery of 2-Aminobenzimidazoles That Sensitize Mycobacterium smegmatis and M. tuberculosis to beta-Lactam Antibiotics in a Pattern Distinct from beta-Lactamase Inhibitors}, volume={56}, ISSN={["1521-3773"]}, DOI={10.1002/anie.201612006}, abstractNote={Abstract}, number={14}, journal={ANGEWANDTE CHEMIE-INTERNATIONAL EDITION}, author={Nguyen, T. Vu and Blackledge, Meghan S. and Lindsey, Erick A. and Minrovic, Bradley M. and Ackart, David F. and Jeon, Albert B. and Obregon-Henao, Andres and Melander, Roberta J. and Basaraba, Randall J. and Melander, Christian}, year={2017}, month={Mar}, pages={3940–3944} }
 @article{garrido_simpson_dahl_bresee_whitehead_lindsey_harris_smith_carter_feldheim_et al._2015, title={Gold nanoparticles to improve HIV drug delivery}, volume={7}, ISSN={["1756-8927"]}, DOI={10.4155/fmc.15.57}, abstractNote={ Background: Antiretroviral therapy (ART) has improved lifespan and quality of life of patients infected with the HIV-1. However, ART has several potential limitations, including the development of drug resistance and suboptimal penetration to selected anatomic compartments. Improving the delivery of antiretroviral molecules could overcome several of the limitations of current ART. Results & Conclusion: Two to ten nanometer diameter inorganic gold crystals serve as a base scaffold to combine molecules with an array of properties in its surface. We show entry into different cell types, antiviral activity of an HIV integrase inhibitor conjugated in a gold nanoparticle and penetration into the brain in vivo without toxicity. Herein, gold nanoparticles prove to be a promising tool to use in HIV therapy. }, number={9}, journal={FUTURE MEDICINAL CHEMISTRY}, author={Garrido, Carolina and Simpson, Carrie A. and Dahl, Noelle P. and Bresee, Jamee and Whitehead, Daniel C. and Lindsey, Erick A. and Harris, Tyler L. and Smith, Candice A. and Carter, Carly J. and Feldheim, Daniel L. and et al.}, year={2015}, pages={1097–1107} }
 @article{ackart_lindsey_podell_melander_basaraba_melander_2014, title={Reversal of Mycobacterium tuberculosis phenotypic drug resistance by 2-aminoimidazole- based small molecules}, volume={70}, ISSN={["2049-632X"]}, DOI={10.1111/2049-632x.12143}, abstractNote={The expression of phenotypic drug resistance or drug tolerance serves as a strategy for Mycobacterium tuberculosis to survive in vivo antimicrobial drug treatment; however, the mechanisms are poorly understood. Progress toward a more in depth understanding of in vivo drug tolerance and the discovery of new therapeutic strategies designed specifically to treat drug-tolerant M. tuberculosis are hampered by the lack of appropriate in vitro assays. A library of 2-aminoimidazole-based small molecules combined with the antituberculosis drug isoniazid was screened against M. tuberculosis expressing in vitro drug tolerance as microbial communities attached to an extracellular matrix derived from lysed leukocytes. Based on the ability of nine of ten 2-aminoimidazole compounds to inhibit Mycobacterium smegmatis biofilm formation and three of ten molecules capable of dispersing established biofilms, two active candidates and one inactive control were tested against drug-tolerant M. tuberculosis. The two active compounds restored isoniazid susceptibility as well as reduced the in vitro minimum inhibitory concentrations of isoniazid in a dose-dependent manner. The dispersion of drug-tolerant M. tuberculosis with 2-aminoimidazole-based small molecules as an adjunct to antimicrobial treatment has the potential to be an effective antituberculosis treatment strategy designed specifically to eradicate drug-tolerant M. tuberculosis.}, number={3}, journal={PATHOGENS AND DISEASE}, author={Ackart, David F. and Lindsey, Erick A. and Podell, Brendan K. and Melander, Roberta J. and Basaraba, Randall J. and Melander, Christian}, year={2014}, month={Apr}, pages={370–378} }
 @article{lindsey_worthington_alcaraz_melander_2012, title={2-Aminopyrimidine as a novel scaffold for biofilm modulation}, volume={10}, number={13}, journal={Organic & Biomolecular Chemistry}, author={Lindsey, E. A. and Worthington, R. J. and Alcaraz, C. and Melander, C.}, year={2012}, pages={2552–2561} }
 @article{rogers_lindsey_whitehead_mullikin_melander_2011, title={Synthesis and biological evaluation of 2-aminoimidazole/carbamate hybrid anti-biofilm and anti-microbial agents}, volume={21}, ISSN={["1464-3405"]}, DOI={10.1016/j.bmcl.2010.12.057}, abstractNote={The successful marriage of structural features from our 2-aminoimidazole and menthyl carbamate classes of anti-biofilm agents has resulted in the development of a novel hybrid scaffold of biofilm modulators. The compounds were evaluated against a panel of four bacterial strains for anti-biofilm and anti-microbial activity.}, number={4}, journal={BIOORGANIC & MEDICINAL CHEMISTRY LETTERS}, author={Rogers, Steven A. and Lindsey, Erick A. and Whitehead, Daniel C. and Mullikin, Trey and Melander, Christian}, year={2011}, month={Feb}, pages={1257–1260} }