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Ethan Hicks

Works (1)

Updated: July 5th, 2023 15:36

2017 journal article

Investigation of interfacial properties of pure and mixed poloxamers for surfactant-mediated shear protection of mammalian cells

COLLOIDS AND SURFACES B-BIOINTERFACES, 156, 358–365.

By: D. Chang n, R. Fox  n, E. Hicks n, R. Ferguson*, K. Chang *, D. Osborne *, W. Hu*, O. Velev n 

author keywords: Poloxamer; Mammalian cells; Shear sensitivity; Interfacial tension; Foam stability; Bioreactors
MeSH headings : Animals; CHO Cells; Cell Survival / drug effects; Cells, Cultured; Cricetulus; Poloxamer / chemistry; Poloxamer / pharmacology; Surface Tension; Surface-Active Agents / chemistry; Surface-Active Agents / pharmacology
topics (OpenAlex): Fluid Dynamics and Mixing; Electrohydrodynamics and Fluid Dynamics; Pickering emulsions and particle stabilization
TL;DR: The mechanism of disruption by P407 was determined to be independent of cell-to-bubble attachment, suggesting that poloxamer adsorption to and subsequent reinforcement of the cell membrane may play a key role in protecting cells in high shear environments. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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