Elisa Crisci
Also known as: Eli
virology, immunology, virus-host interactions, pig
I think about myself as a "viro-immunologist". I have a veterinary background and I'm working in veterinary virology, immunology, and vaccinology, mainly in pigs. I also worked in human viral infections (influenza, HIV, HSV2). I was always interested in innate immunity and cellular responses against viral infections. I have worked with complement system, virus-like particles, different RNA and DNA viruses. I promote the use of pig as large biomedical model for human research.
Works (64)
Updated: December 18th, 2024 13:00
2024 article
Defining Cellular Diversity at the Swine Maternal-Fetal Interface Using Spatial Transcriptomics and Organoids
McCutcheon, C. R., Caldwell, A., Yang, L., Crisci, E., Pasternak, J. A., & Coyne, C. B. (2024, October 22).
open access via doi.org (repository)
Source: ORCID
Added: October 22, 2024
2024 article
Human long noncoding RNA,VILMIR, is induced by major respiratory viral infections and modulates the host interferon response
John, K., Huntress, I., Smith, E., Chou, H., Tollison, T. S., Covarrubias, S., … Peng, X. (2024, March 29).
TL;DR:
The results show that VILMIR is a novel interferon-stimulated gene (ISG) that regulates the host interferon response and may be a potential therapeutic target for human respiratory viral infections upon further mechanistic investigation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: April 1, 2024
2024 article
Prolonged airway explant culture enables study of health, disease, and viral pathogenesis
Lee-Ferris, R., Okuda, K., Galiger, J. R., Schworer, S. A., Rogers, T. D., Dang, H., … Randell, S. H. (2024, February 5).
TL;DR:
Methods to culture human large airway explants, small airway explants, and precision-cut lung slices for at least 14 days and their use as translational intermediates between in vitro and in vivo studies are described.
(via Semantic Scholar)
Source: ORCID
Added: March 8, 2024
2023 journal article
A rapid, high-throughput, viral infectivity assay using automated brightfield microscopy with machine learning
SLAS Technology, 28(5), 324–333.
author keywords: Viral infectivity assay; Antiviral screening; Brightfield microscopy; Label-free assays; Cell-based assays; Machine learning; Convolutional neural networks
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries, Web Of Science
Added: July 13, 2023
2023 journal article
Testable Candidate Immune Correlates of Protection for Porcine Reproductive and Respiratory Syndrome Virus Vaccination
Vaccines, 11(3), 594.
author keywords: vaccination; PRRSV; correlates of protection; humoral immunity; IgG; neutralizing antibodies; T cell; IFN-gamma
TL;DR:
Applying the breadth of work on human diseases and CoP to PRRSV research, four hypotheses are advocated for peer review and evaluation as appropriate testable CoP and can direct future vaccine design and improve vaccine candidate evaluation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: March 7, 2023
2022 content posted
A Rapid, High Throughput, Viral Infectivity Assay using Automated Brightfield Microscopy with Machine Learning
TL;DR:
An automated assay (AVIA™), using machine learning (ML) and high-throughput brightfield microscopy on 96 well plates that can quantify infection phenotypes within hours, before they are manually visible, and without sample preparation is described.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: March 30, 2022
2022 journal article
Effect of BIO-PLYTM, a Platelet-Rich Plasma Derived Biologic on PRRSV-2-Infected Macrophages
Viruses, 14(12), 2666.
author keywords: antivirals; biologic; porcine macrophages; PRRSV
MeSH headings : Humans; Swine; Animals; Horses; Porcine respiratory and reproductive syndrome virus; Porcine Reproductive and Respiratory Syndrome / prevention & control; Macrophages; Biological Products
TL;DR:
The results show that BIO-PLYTM significantly reduces the amount of PRRSV viral load determined by RT-qPCR and the number of infectious viral particles measured by TCID50 in infected porcine alveolar and parenchymal macrophages.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: November 29, 2022
2022 journal article
From Open Access to Circular Health: Ilaria Capua’s Journey through Science and Politics
Viruses, 14(6), 1296.
author keywords: Ilaria Capua; open access; circular health; one health; influenza virus
MeSH headings : Access to Information; Animals; Awards and Prizes; Female; Humans; Information Dissemination; Politics
TL;DR:
This paper highlights the career of an exceptional woman virologist, Dr. Ilaria Capua, and describes how she became the long-term champion of “Open Access” and “Data Sharing” for virus genetic sequences and introduces her new concept of ”Circular Health”, where health becomes a circular system that represents a central and vital connection hub between humans and nature.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: June 15, 2022
2022 journal article
Heterologous vaccine immunogenicity, efficacy, and immune correlates of protection of a modified-live virus porcine reproductive and respiratory syndrome virus vaccine
Frontiers in Microbiology, 13.
author keywords: porcine reproductive and respiratory syndrome virus (PRRSV); correlates of protection (CoP); vaccination; swine; immunity; pig
TL;DR:
Overall, the Prevacent elicited various degrees of efficacy and immunogenicity against four heterologous and phylogenetically distant strains of PRRSV-2, and correlation analyses revealed that the (non-PRRSV strain-specific) serum IgG levels and the PRRSv strain- specific CD4 T-cell response were the best immune correlates of protection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: September 25, 2022
2022 journal article
The health benefits of selenium in food animals: a review
Journal of Animal Science and Biotechnology, 13(1), 58.
author keywords: Antimicrobial; Antioxidant; Food animals; Immunomodulation; Pig; Selenium
TL;DR:
The review demonstrates the gaps in knowledge pertaining to the use of selenium as an antiviral, underscoring the need for further in vivo and in vitro studies, particularly in pigs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: May 13, 2022
2022 journal article
Use of Crystal Violet to Improve Visual Cytopathic Effect-based Reading for Viral Titration using TCID50 Assays
Journal of Visualized Experiments, 2(180).
MeSH headings : Animals; Cell Line; Cytopathogenic Effect, Viral; Gentian Violet; Influenza A virus; Reading; Swine
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
4. Quality Education
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: June 13, 2022
2021 journal article
A Liquid Metal Mediated Metallic Coating for Antimicrobial and Antiviral Fabrics
Advanced Materials, 33(45), 2104298.
author keywords: antimicrobial; antiviral; galvanic replacement; liquid metal fabric coating
MeSH headings : Alloys / chemistry; Anti-Infective Agents / chemistry; Anti-Infective Agents / pharmacology; Antiviral Agents / chemistry; Antiviral Agents / pharmacology; Bacteria / drug effects; Coated Materials, Biocompatible / chemistry; Coated Materials, Biocompatible / pharmacology; Copper / chemistry; Fungi / drug effects; Gallium / chemistry; Textiles / analysis; Viruses / drug effects
TL;DR:
The presence of the LMCu particles can eradicate over 99% of pathogens within 5 min, which is significantly more effective than control samples coated with only Cu, and is promising for generating robust antibacterial, antifungal, and antiviral fabrics and surfaces.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: September 28, 2021
2021 journal article
Complement-Opsonized HIV Modulates Pathways Involved in Infection of Cervical Mucosal Tissues: A Transcriptomic and Proteomic Study
Frontiers in Immunology, 12.
author keywords: HIV; human immunodeficiency virus; innate immunity; complement opsonized HIV-1; transcriptomics; proteomics; cervical tissue; primary infection
MeSH headings : Cervix Uteri / immunology; Cervix Uteri / metabolism; Cervix Uteri / virology; Complement System Proteins / immunology; Dendritic Cells / immunology; Dendritic Cells / metabolism; Dendritic Cells / virology; Female; Gene Expression Profiling; Gene Expression Regulation; HIV Infections / genetics; HIV Infections / immunology; HIV Infections / metabolism; HIV Infections / virology; HIV-1 / growth & development; HIV-1 / immunology; HIV-1 / pathogenicity; Host-Pathogen Interactions; Humans; Immunity, Innate; Mucous Membrane / immunology; Mucous Membrane / metabolism; Mucous Membrane / virology; Proteome; Proteomics; Signal Transduction; T-Lymphocytes / immunology; T-Lymphocytes / metabolism; T-Lymphocytes / virology; Time Factors; Tissue Culture Techniques; Transcriptome; Virus Internalization; Virus Replication
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: July 1, 2021
2021 journal article
Corrigendum: Complement-Opsonized HIV Modulates Pathways Involved in Infection of Cervical Mucosal Tissues: A Transcriptomic and Proteomic Study.
Frontiers in Immunology.
author keywords: cervical tissue; complement opsonized HIV-1; innate immunity; primary infection; proteomics; transcriptomics; HIV-human immunodeficiency virus
TL;DR:
This research presents a novel probabilistic approach to estimating the response of the immune system to laser-spot assisted, 3D image analysis of the central nervous system.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 27, 2021
2021 journal article
Maternal Autogenous Inactivated Virus Vaccination Boosts Immunity to PRRSV in Piglets
VACCINES, 9(2).
author keywords: maternal vaccination; autogenous inactivated vaccine; transfer of immunity; humoral immune response; cell-mediated immune response; T cells; PRRSV; swine; IFN-gamma producing B cells; CD4 T-EMRA cells
TL;DR:
It is demonstrated that maternal AIV vaccination can improve protection of pre-weaning piglets against PRRSV-2 and shows the importance of transferring neutralizing antibodies to piglets, and it introduces two novel immune cell subsets in pigs—IFN-γ producing CD21α+ B cells and CD8α−CCR7− CD4 T cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 1, 2021
2021 journal article
The Local and Systemic Humoral Immune Response Against Homologous and Heterologous Strains of the Type 2 Porcine Reproductive and Respiratory Syndrome Virus
Frontiers in Immunology, 12.
author keywords: adaptive immunity; humoral immunity; neutralizing antibodies; IgA; IgG; porcine reproductive and respiratory syndrome virus
MeSH headings : Animals; Antibodies, Neutralizing / blood; Flow Cytometry / methods; Immunity, Humoral / immunology; Immunoglobulin A / analysis; Immunoglobulin A / immunology; Immunoglobulin G / blood; Nasal Mucosa / immunology; Nasal Mucosa / virology; Porcine Reproductive and Respiratory Syndrome / immunology; Porcine respiratory and reproductive syndrome virus / immunology; Swine; Vaccination; Viral Vaccines / immunology; Viremia / immunology; Viremia / virology
TL;DR:
This study improves the understanding of the relationship between local and systemic infections and the humoral immune response induced by PRRSV-2 infection or MLV vaccination and provides novel insights into the timeline of the development of homologous and heterologous NA levels – by bothMLV vaccination or infection with two strains from the currently prevalent PRRSv-2 lineage 1.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: March 29, 2021
2021 journal article
The Local and Systemic Humoral Immune Response Against Homologous and Heterologous Strains of the Type 2 Porcine Reproductive and Respiratory Syndrome Virus
Frontiers in Immunology, 1. http://europepmc.org/abstract/PMC/PMC7985350
Source: ORCID
Added: March 27, 2021
2021 journal article
Whole Genome or Single Genes? A Phylodynamic and Bibliometric Analysis of PRRSV
Frontiers in Veterinary Science, 8.
author keywords: bibliometrics; phylodynamics; pig; PRRSV; ORF5; whole genome
TL;DR:
This study provides an exploration of the two main phylogenetic research lines applied for PRRSV evolution, as well as an example of the differences found when both methods are applied to the same database.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: July 19, 2021
2020 journal article
A Century of Swine Influenza: Is It Really Just about the Pigs?
Veterinary Sciences, 7(4), 189.
author keywords: bibliometrics; swine influenza virus; influenza variants; GenBank; global health
TL;DR:
It is observed that the 2009 H1N1 human pandemic created an important bias in SwIV research driven by an increase in human publications on the IV of swine origin and will serve as a guidance for future search strategies in Sw IV research.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: ORCID
Added: December 1, 2020
2020 journal article
Distinctive Cellular and Metabolic Reprogramming in Porcine Lung Mononuclear Phagocytes Infected With Type 1 PRRSV Strains
Frontiers in Immunology, 11.
MeSH headings : Animals; Female; Lung / cytology; Monocytes / immunology; Monocytes / virology; Porcine Reproductive and Respiratory Syndrome / genetics; Porcine Reproductive and Respiratory Syndrome / immunology; Porcine respiratory and reproductive syndrome virus; Swine; Transcriptome
TL;DR:
Data indicates that cellular reprogramming differs upon Lena and FL13 infection and that the latter might keep antiviral and inflammatory macrophage/DC functions silent, and suggest distinct mechanisms of interaction of the two viruses with the innate immune system during early infection.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: January 10, 2021
2020 article
Maternal Autogenous Inactivated Virus Vaccination Boosts the Piglet Humoral and Cell-Mediated Immunity to PRRSV via Transfer of Neutralizing Antibodies and Interferon-Gamma Producing B Cells
Kick, A. R., Wolfe, Z. C., Amaral, A. F., Cortes, L. M., Almond, G. W., Crisci, E., … Käser, T. (2020, December 3). (Vol. 12). Vol. 12.
TL;DR:
It is demonstrated that maternal AIV vaccination can improve protection of pre-weaning piglets against PRRSV-2 and shows the importance of transferring neutralizing antibodies to piglets; and it introduces two novel immune cell subsets in pigs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: December 3, 2020
2020 journal article
Priming for welfare: gut microbiota is associated with equitation conditions and behavior in horse athletes
Scientific Reports, 10(1).
MeSH headings : Animals; Behavior, Animal; Biodiversity; Cohort Studies; Environment; Feces / microbiology; Female; Gastrointestinal Microbiome / physiology; Health Status; Horses / microbiology; Horses / physiology; Male; Phenotype; Physical Conditioning, Animal; Sports
TL;DR:
Among a suite of variables examined, equitation factors were highly associated with the gut microbiota variability, evoking a relationship between gut microbiota and high levels of physical and mental stressors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: July 6, 2020
2019 journal article
Cellular Innate Immunity against PRRSV and Swine Influenza Viruses
Veterinary Sciences, 6(1), 26.
author keywords: pig; innate immunity; PRRSV; swine influenza virus
TL;DR:
This review focuses on the interactions of two enveloped RNA viruses—porcine reproductive and respiratory syndrome virus (PRRSV) and swine influenza virus (SwIV)—as major etiological agents that contribute to PRDC within the porcine cellular innate immunity during infection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: March 16, 2019
2019 journal article
HSV-2 Cellular Programming Enables Productive HIV Infection in Dendritic Cells
Frontiers in Immunology, 10.
author keywords: HSV-2; HIV-1; HSV-2 and HIV-1 coinfection; dendritic cells; immune responses; DNA sensors
MeSH headings : Coinfection; Cytokines / metabolism; Dendritic Cells / immunology; Dendritic Cells / metabolism; Disease Susceptibility; HIV Infections / immunology; HIV Infections / metabolism; HIV Infections / virology; HIV-1 / physiology; Herpes Genitalis / immunology; Herpes Genitalis / metabolism; Herpes Genitalis / virology; Herpesvirus 2, Human / physiology; Host-Pathogen Interactions / immunology; Humans; Inflammation Mediators / metabolism; Membrane Proteins / metabolism; Nucleotidyltransferases / metabolism; Signal Transduction; Symbiosis
TL;DR:
It is shown that HSV-2 reprogramming of cellular signaling pathways and protein expression levels in the DCs provided a setting where HIV-1 can establish a higher productive infection in theDCs and creates a microenvironment favoring HIV- 1 transmission.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 12, 2019
2019 journal article
Macrophage-B Cell Interactions in the Inverted Porcine Lymph Node and Their Response to Porcine Reproductive and Respiratory Syndrome Virus
Frontiers in Immunology, 10.
author keywords: swine; lymph node; PRRSV; macrophage; B cell; centrocyte; BCL6
MeSH headings : Animals; B-Lymphocytes / immunology; Lymph Nodes / immunology; Macrophages / immunology; Porcine Reproductive and Respiratory Syndrome / immunology; Porcine respiratory and reproductive syndrome virus; Swine
TL;DR:
The different intra and extrafollicular stages of LN B cells maturation were identified and the interaction of MΦ, drained antigen and follicular B cells was explored and led to new hypothesis on PRRSV inhibition of B cell maturation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: May 28, 2019
2019 journal article
Multi-species annotation of transcriptome and chromatin structure in domesticated animals
BMC Biology, 17(1).
author keywords: Functional annotation; Livestock; RNA-seq; ATAC-seq; Hi-C
MeSH headings : Animals; Animals, Domestic / genetics; Cattle; Chickens; Chromatin / genetics; Goats; Molecular Sequence Annotation; Phylogeny; Sus scrofa; Transcriptome
TL;DR:
The first multi-species and multi-assay genome annotation results obtained by a FAANG project are reported, showing that conserved TAD boundaries had stronger insulation properties than species-specific ones and that the genomic distribution of orthologous genes in A/B compartments was significantly conserved across species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: January 4, 2020
2019 journal article
The T-Cell Response to Type 2 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV)
Viruses, 11(9), 796.
author keywords: PRRSV; T cells; adaptive immunity; treg; thelper; Cytotoxic proliferation; TCR-gamma delta; IFN-gamma
MeSH headings : Adaptive Immunity; Animals; Kinetics; Lung / immunology; Lung / virology; Lymph Nodes / immunology; Lymph Nodes / virology; Porcine Reproductive and Respiratory Syndrome / immunology; Porcine Reproductive and Respiratory Syndrome / pathology; Porcine Reproductive and Respiratory Syndrome / virology; Porcine respiratory and reproductive syndrome virus / growth & development; Porcine respiratory and reproductive syndrome virus / immunology; Porcine respiratory and reproductive syndrome virus / pathogenicity; Receptors, Antigen, T-Cell, gamma-delta / metabolism; Receptors, Lymphocyte Homing / metabolism; Swine; T-Lymphocyte Subsets / immunology; T-Lymphocyte Subsets / virology; T-Lymphocytes / immunology; T-Lymphocytes / virology; Vaccines, Attenuated; Viral Vaccines / immunology; Viremia / immunology; Viremia / virology
TL;DR:
The results demonstrate an important role for T cells in this homo- and heterologous response to type-2 PRRSV, and the T-helper cells were the main responders during viremia, while the cytotoxic T lymphocyte response was the strongest at the site of infection—the lung and bronchoalveolar lavage.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: August 30, 2019
2019 journal article
The miRNA-targeted transcriptome of porcine alveolar macrophages upon infection with Porcine Reproductive and Respiratory Syndrome Virus
Scientific Reports, 9(1).
MeSH headings : Animals; Gene Expression Regulation / genetics; Macrophages, Alveolar / metabolism; Macrophages, Alveolar / pathology; MicroRNAs / genetics; MicroRNAs / isolation & purification; Oligonucleotide Array Sequence Analysis; Porcine Reproductive and Respiratory Syndrome / genetics; Porcine Reproductive and Respiratory Syndrome / pathology; Porcine Reproductive and Respiratory Syndrome / virology; Porcine respiratory and reproductive syndrome virus / genetics; Porcine respiratory and reproductive syndrome virus / pathogenicity; Signal Transduction / genetics; Swine; Transcriptome / genetics
TL;DR:
It is indicated that the miRNome expressed by steady-state PAMs reacts promptly to counterbalance PRRSV infection by a pervasive modulation of host functions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: March 11, 2019
2018 journal article
Livestock genome annotation: transcriptome and chromatin structure profiling in cattle, goat, chicken and pig.
TL;DR:
Multi-species comparisons showed that conserved TAD boundaries had stronger insulation properties than species-specific ones and that the genomic distribution of orthologous genes in A/B compartments was significantly conserved across species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: ORCID
Added: February 11, 2019
2018 journal article
Porcine Alveolar Macrophage-like cells are pro-inflammatory Pulmonary Intravascular Macrophages that produce large titers of Porcine Reproductive and Respiratory Syndrome Virus
Scientific Reports, 8(1).
MeSH headings : Animals; Cells, Cultured; Female; Lung / cytology; Lung / immunology; Lung / virology; Macrophages, Alveolar / immunology; Macrophages, Alveolar / virology; Phagocytosis; Porcine Reproductive and Respiratory Syndrome / immunology; Porcine Reproductive and Respiratory Syndrome / virology; Porcine respiratory and reproductive syndrome virus / immunology; Porcine respiratory and reproductive syndrome virus / pathogenicity; Primary Cell Culture; Specific Pathogen-Free Organisms; Sus scrofa; Swine; Swine, Miniature; Viremia / immunology; Viremia / virology
TL;DR:
It is shown that AM-like cells are macrophages phagocytosing blood-borne particles, in agreement with a pulmonary intravascular macrophage (PIM) identity, which raised the interesting possibility that AM and PIM originate from the same lung precursor.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Crossref, NC State University Libraries
Added: February 11, 2019
2018 journal article
Porcine Reproductive and Respiratory Syndrome Virus Type 1.3 Lena Triggers Conventional Dendritic Cells 1 Activation and T Helper 1 Immune Response Without Infecting Dendritic Cells
Frontiers in Immunology, 9.
author keywords: PRRSV; Lena; lung; dendritic cells; cDc1; Th1 response; cellular response
MeSH headings : Animals; Biomarkers; Cytokines / metabolism; Dendritic Cells / immunology; Dendritic Cells / metabolism; Lymphocyte Activation / immunology; Lymphocyte Culture Test, Mixed; Porcine Reproductive and Respiratory Syndrome / immunology; Porcine Reproductive and Respiratory Syndrome / metabolism; Porcine Reproductive and Respiratory Syndrome / virology; Porcine respiratory and reproductive syndrome virus / immunology; Swine; T-Lymphocyte Subsets / immunology; T-Lymphocyte Subsets / metabolism; T-Lymphocytes, Helper-Inducer / immunology; T-Lymphocytes, Helper-Inducer / metabolism
TL;DR:
In vitro investigation of T helper polarization and cytokines production demonstrate that Lena induces a higher Th1 polarization and IFNγ secretion than FL13 and LV, which suggests an activation of cDC1 by Lena associated with a Th1 immune response polarization.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: October 16, 2018
2017 journal article
HIV/Human herpesvirus co-infections: Impact on tryptophan-kynurenine pathway and immune reconstitution
PLOS ONE, 12(10), e0186000.
Ed(s): O. Sued
MeSH headings : Adult; Antibodies, Viral / blood; Antiretroviral Therapy, Highly Active; CD4-Positive T-Lymphocytes / immunology; Coinfection / blood; Coinfection / epidemiology; Coinfection / immunology; Coinfection / virology; Female; HIV Infections / blood; HIV Infections / epidemiology; HIV Infections / immunology; HIV Infections / virology; Herpes Simplex / blood; Herpes Simplex / epidemiology; Herpes Simplex / immunology; Herpes Simplex / virology; Herpesvirus 1, Human / isolation & purification; Herpesvirus 1, Human / pathogenicity; Humans; Immune Reconstitution Inflammatory Syndrome / blood; Immune Reconstitution Inflammatory Syndrome / immunology; Immune Reconstitution Inflammatory Syndrome / metabolism; Immune Reconstitution Inflammatory Syndrome / virology; Inflammation / blood; Inflammation / epidemiology; Inflammation / immunology; Inflammation / virology; Kynurenine / metabolism; Male; Metabolic Networks and Pathways; Seroepidemiologic Studies; Tryptophan / metabolism
TL;DR:
Multiple HHV co-infections are common among ART-treated HIV-infected participants in the developing country setting and associated with persistent immune activation and poorer CD4 T-cell recovery.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: February 11, 2019
2017 conference paper
Integrative and differential analysis of transcriptomes and chromatin accessibility regions reveals regulatory mechanisms involved in pig immune and metabolic functions
36th International Society for Animal Genetics Conference, np.
Source: ORCID
Added: February 11, 2019
2017 journal article
Pig as a biomedical model: Putting the porcine lung dendritic cells/macrophages network into light
Revue Des Maladies Respiratoires, 34, A328.
Source: ORCID
Added: February 11, 2019
2016 journal article
Complement Opsonization Promotes Herpes Simplex Virus 2 Infection of Human Dendritic Cells
Journal of Virology, 90(10), 4939–4950.
Ed(s): J. Jung
MeSH headings : Antibodies, Viral / immunology; Complement System Proteins / immunology; Complement System Proteins / metabolism; Cytokines / immunology; Dendritic Cells / immunology; Dendritic Cells / virology; Herpes Simplex / immunology; Herpesvirus 2, Human / immunology; Herpesvirus 2, Human / physiology; Humans; Opsonin Proteins / immunology; Virion / metabolism
TL;DR:
The results demonstrate that the presence of antibodies and complement in the genital environment can influence HSV-2 infection under in vitro conditions that reflect the in vivo situation.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: February 11, 2019
2016 journal article
Rabbit hemorrhagic disease virus capsid, a versatile platform for foreign B-cell epitope display inducing protective humoral immune responses.
Scientific Reports, 6, 31844, http://europepmc.org/abstract/med/27549017
Source: ORCID
Added: February 11, 2019
2015 journal article
Impaired NK Cell Activation and Chemotaxis toward Dendritic Cells Exposed to Complement-Opsonized HIV-1
The Journal of Immunology, 195(4), 1698–1704.
MeSH headings : Cell Line; Chemokines / biosynthesis; Chemotaxis / immunology; Complement System Proteins / immunology; Cytotoxicity, Immunologic; Dendritic Cells / immunology; Dendritic Cells / metabolism; HIV Infections / immunology; HIV-1 / immunology; Humans; Killer Cells, Natural / immunology; Killer Cells, Natural / metabolism; Lymphocyte Activation / immunology
TL;DR:
The impairment of NK cell recruitment by DCs exposed to complement-opsonized HIV and the lack of NK activation may contribute to the failure of innate immune responses to control HIV at the site of initial mucosa infection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: February 11, 2019
2015 journal article
The respiratory DC/macrophage network at steady-state and upon influenza infection in the swine biomedical model
Mucosal Immunology, 9(4), 835–849.
MeSH headings : Animals; Antigens, CD / metabolism; Cells, Cultured; Dendritic Cells / immunology; Dendritic Cells / virology; Disease Models, Animal; Humans; Influenza, Human / immunology; Lectins, C-Type / metabolism; Lymphocyte Activation; Macrophages / immunology; Macrophages / virology; Macrophages, Alveolar / immunology; Macrophages, Alveolar / virology; Mannose-Binding Lectins / metabolism; Mice; Orthomyxoviridae / immunology; Orthomyxoviridae Infections / immunology; Receptors, IgE / metabolism; Respiratory System / immunology; Swine; Th1 Cells / immunology; Th2 Cells / immunology
TL;DR:
By unraveling the extended similarities of the porcine and human lung dendritic cells/macrophages networks, this work highlights the relevance of pig, both as an exploratory model of DC/Mθ functions and as a model for human inflammatory lung pathologies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: February 11, 2019
2014 journal article
Complement Opsonization of HIV-1 Results in Decreased Antiviral and Inflammatory Responses in Immature Dendritic Cells via CR3.
Journal of Immunology, 193(9), 4590–4601.
MeSH headings : Complement System Proteins / immunology; Dendritic Cells / immunology; Dendritic Cells / metabolism; Dendritic Cells / virology; Extracellular Signal-Regulated MAP Kinases / metabolism; Gene Expression Profiling; HIV Infections / genetics; HIV Infections / immunology; HIV Infections / metabolism; HIV-1 / immunology; Humans; Immunity, Innate / genetics; Inflammation / genetics; Inflammation / immunology; Inflammation / metabolism; Interferon Regulatory Factor-1 / metabolism; Interferon Regulatory Factor-3 / metabolism; Macrophage-1 Antigen / metabolism; Models, Biological; NF-kappa B / metabolism; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Transport; RNA, Messenger / genetics; RNA, Messenger / metabolism; Signal Transduction; Toll-Like Receptor 8 / metabolism; p38 Mitogen-Activated Protein Kinases / metabolism; src-Family Kinases / metabolism
TL;DR:
The impact that viral hijacking of the complement system has on iDC function could be an important immune evasion mechanism used by HIV-1 to establish infection in the host.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: February 11, 2019
2014 journal article
In vivo tracking and immunological properties of pulsed porcine monocyte-derived dendritic cells
Molecular Immunology, 63(2), 343–354.
author keywords: Pig; DC tracking; MRI; Virus-like particles; Immunotherapy
MeSH headings : Animals; Cell Shape; Cell Survival; Cell Tracking / methods; Dendritic Cells / cytology; Dendritic Cells / immunology; Dextrans / metabolism; Enzyme-Linked Immunospot Assay; Humans; Immunization; Immunohistochemistry; Interferon-gamma / metabolism; Lymph Nodes / pathology; Magnetic Resonance Imaging; Magnetite Nanoparticles; Monocytes / cytology; Phenotype; Staining and Labeling; Sus scrofa
TL;DR:
The results showed that after one single subcutaneous dose of pulsed MoDCs, pigs were able to elicit specific local and systemic immune responses and the dynamic imaging of MRI-based DC tracking was shown using SPIO particles.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: February 11, 2019
2013 journal article
Immune characterization of long pentraxin 3 in pigs infected with influenza virus.
Veterinary Microbiology, 168(1), 185–192.
author keywords: PTX3; Pigs; DC; Influenza virus
MeSH headings : Amino Acid Sequence; Animals; Antibodies, Viral / metabolism; C-Reactive Protein / genetics; C-Reactive Protein / immunology; Cross Reactions / immunology; Dendritic Cells / virology; Gene Expression Regulation / immunology; Immunity, Innate; Orthomyxoviridae / immunology; Orthomyxoviridae Infections / immunology; Orthomyxoviridae Infections / pathology; Orthomyxoviridae Infections / veterinary; Orthomyxoviridae Infections / virology; Sequence Alignment; Serum Amyloid P-Component / genetics; Serum Amyloid P-Component / immunology; Swine; Swine Diseases / immunology; Swine Diseases / pathology; Swine Diseases / virology
TL;DR:
The initial characterization of SwPTX3 in influenza virus infected pigs contributes to understand the role of PTX proteins in the immune response.
(via Semantic Scholar)
Source: ORCID
Added: February 11, 2019
2013 journal article
Review: influenza virus in pigs.
Molecular Immunology, 55(3-4), 200–211.
author keywords: Pig; Influenza virus; Immune responses
MeSH headings : Animals; Disease Models, Animal; Host-Pathogen Interactions / immunology; Humans; Influenza A Virus, H1N1 Subtype / immunology; Influenza, Human / immunology; Influenza, Human / pathology; Orthomyxoviridae Infections / immunology; Orthomyxoviridae Infections / veterinary; Orthomyxoviridae Infections / virology; Sus scrofa; Swine; Swine Diseases / immunology; Swine Diseases / virology
TL;DR:
The increased acceptance of pigs as suitable and valuable models in the scientific community may stimulate the development of new tools to assess porcine immune responses, paving the way for their consideration as the future "gold standard" large-animal model in immunology.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: February 11, 2019
2013 journal article
Seudopart́ıculas virales como vacunas v́ıricas en veterinaria
Inmunoloǵıa (1987), 102–106.
Source: ORCID
Added: February 11, 2019
2012 journal article
Chimeric calicivirus-like particles elicit specific immune responses in pigs
Vaccine, 30(14), 2427–2439.
author keywords: RHDV-VLPs; Vaccine vector; 3A; FMDV; Pigs
MeSH headings : Acute-Phase Proteins / metabolism; Amino Acid Sequence; Animals; Antibodies, Viral / immunology; Antibody Specificity; Cytokines / metabolism; Dendritic Cells / immunology; Dendritic Cells / metabolism; Epitopes, T-Lymphocyte / chemistry; Epitopes, T-Lymphocyte / immunology; Hemorrhagic Disease Virus, Rabbit / immunology; Humans; Immunity; Immunity, Cellular; Male; Molecular Sequence Data; Swine / immunology; Vaccines, Virus-Like Particle / immunology; Viral Proteins / chemistry; Viral Proteins / immunology
TL;DR:
This is the first immunological report on the potential use of chimeric R HDV-VLPs as antigen carriers in pigs and the adjuvanted group exhibited the highest IFN-γ-secreting cell numbers and lymphoproliferative specific T cell responses against 3A epitope and RHDV-VLP.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: February 11, 2019
2012 journal article
Immunogenic properties of calicivirus-like particles as vaccine vectors
Source: ORCID
Added: February 11, 2019
2012 journal article
Immunomodulatory properties of beta-sitosterol in pig immune responses.
International Immunopharmacology, 13(3), 316–321.
author keywords: Phytosterols; Immunomodulator; PRRSV; Swine
MeSH headings : Animal Feed; Animals; Apolipoprotein A-I / blood; Dendritic Cells / drug effects; Dendritic Cells / immunology; Female; Immunologic Factors / administration & dosage; Immunologic Factors / pharmacology; In Vitro Techniques; Leukocyte Count; Lymphocyte Activation / drug effects; Male; Porcine respiratory and reproductive syndrome virus / immunology; Sitosterols / administration & dosage; Sitosterols / pharmacology; Spain; Sus scrofa / blood; Sus scrofa / immunology; Viral Vaccines / administration & dosage
TL;DR:
The data in this report show that BSS can be considered an immunomodulator in pigs after vaccination with porcine reproductive and respiratory syndrome virus (PRRSV) modified life vaccine (MLV).
(via Semantic Scholar)
Source: ORCID
Added: February 11, 2019
2012 journal article
Virus-like particle-based vaccines for animal viral infections
Inmunología, 32(3), 102–116.
TL;DR:
The current status of VLPs as a vaccine strategy in the veterinary field is reviewed and the potential advantages and challenges of this technology are discussed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: February 11, 2019
2012 journal article
Virus-like particles: the new frontier of vaccines for animal viral infections.
Veterinary Immunology and Immunopathology, 148(3-4), 211–225.
author keywords: Virus-like particles (VLPs); Animal vaccines; Vaccine vectors
MeSH headings : Animals; Chickens / immunology; Chickens / virology; Poultry Diseases / prevention & control; Poultry Diseases / virology; Swine / immunology; Swine / virology; Swine Diseases / prevention & control; Swine Diseases / virology; Vaccines, Virus-Like Particle / immunology; Vaccines, Virus-Like Particle / therapeutic use; Virus Diseases / immunology; Virus Diseases / prevention & control; Virus Diseases / veterinary
TL;DR:
The current status of VLPs as a vaccine technology in the veterinary field is reviewed, and the potential advantages and challenges of this technology are discussed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: February 11, 2019
2012 journal article
phenoypical characterization and isolation of a subpopulation of myeloid cells from swine peripheral blood: new method to isolate plasmacytoid dendritic cells: p0920
Immunology, 137, 482.
Source: ORCID
Added: February 11, 2019
2011 journal article
DC2010: Forum on Vaccine Science
Inmunología, 30(3), 100–104.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: ORCID
Added: February 11, 2019
2011 journal article
Interaction of porcine conventional dendritic cells with swine influenza virus
Virology, 420(2), 125–134.
author keywords: Influenza virus; Replication; Swine; Dendritic cells
MeSH headings : Animals; Antibodies, Viral / analysis; Bone Marrow Cells / virology; Cell Communication; Cells, Cultured; Cytopathogenic Effect, Viral; Cytoplasm / virology; Dendritic Cells / cytology; Dendritic Cells / immunology; Dendritic Cells / virology; Influenza A Virus, H3N2 Subtype / immunology; Influenza A Virus, H3N2 Subtype / pathogenicity; Swine
TL;DR:
The data generated in these studies reveal the particular interaction of H3N2 SwIV with conventional DCs and viral particles from infected-poBMDCs were able to induce cytopathic effect in susceptible cells only when cell-to-cell interaction was favoured.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: February 11, 2019
2010 journal article
Corrigendum to “A proposal on porcine circovirus type 2 (PCV2) genotype definition and their relation with postweaning multisystemic wasting syndrome (PMWS) occurrence”[Vet. Microbiol. 128 (2008) 23--25]
Veterinary Microbiology, 141(1), 194.
Source: ORCID
Added: February 11, 2019
2010 journal article
Estudien el paper de la citoquina IL-10 en el desenvolupament de la circovirosi porcina
UAB Divulga, 0001–0002.
Source: ORCID
Added: February 11, 2019
2010 journal article
Experimental infection with H1N1 European swine influenza virus protects pigs from an infection with the 2009 pandemic H1N1 human influenza virus.
Veterinary Research, 41(5), 74.
author keywords: influenza virus; swine H1N1; human A(H1N1) 2009; cross-protection
MeSH headings : Animals; Humans; Influenza A Virus, H1N1 Subtype / immunology; Lung / pathology; Orthomyxoviridae Infections / immunology; Orthomyxoviridae Infections / pathology; Orthomyxoviridae Infections / veterinary; Orthomyxoviridae Infections / virology; Pandemics; RNA, Viral; Swine
TL;DR:
Assessment of the risk posed by the A(H1N1) 2009 in the actual situation of swine farms sought to analyze whether a previous infection with a circulating European avian-like swine A/Swine/Spain/53207/2004 generated or not cross-protective immunity against a subsequent infection with the new human pandemic A/Catalonia/63/2009 (H1n1) influenza virus (hereafter referred to as pH1N 1).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: February 11, 2019
2010 journal article
Increased numbers of myeloid and lymphoid IL-10 producing cells in spleen of pigs with naturally occurring postweaning multisystemic wasting syndrome
Veterinary Immunology and Immunopathology, 136(3-4), 305–310.
Source: ORCID
Added: February 11, 2019
2010 journal article
Increased numbers of myeloid and lymphoid IL-10 producing cells in spleen of pigs with naturally occurring postweaning multisystemic wasting syndrome.
Veterinary Immunology and Immunopathology, 136(3-4), 305–310.
author keywords: Postweaning multisystemic wasting syndrome; Porcine circovirus type 2; Immunofluorescence assay; Interleukin-10; Spleen
MeSH headings : Animals; Circoviridae Infections / immunology; Circoviridae Infections / veterinary; Circoviridae Infections / virology; Circovirus / genetics; Circovirus / immunology; Fluorescent Antibody Technique, Indirect / veterinary; Immunophenotyping / methods; Immunophenotyping / veterinary; Interleukin-10 / immunology; Microscopy, Fluorescence; Porcine Postweaning Multisystemic Wasting Syndrome / immunology; Porcine Postweaning Multisystemic Wasting Syndrome / virology; RNA, Viral / blood; Reverse Transcriptase Polymerase Chain Reaction; Spleen / cytology; Spleen / immunology; Spleen / virology; Swine; Viral Load / immunology; Viral Load / veterinary
TL;DR:
This is the first immunophenotyping study on IL-10 producing cells in cases of PMWS, further extending the studies on the role of IL- 10 in disease pathogenesis.
(via Semantic Scholar)
Source: ORCID
Added: February 11, 2019
2009 journal article
A genetically engineered chimeric vaccine against porcine circovirus type 2 (PCV2) improves clinical, pathological and virological outcomes in postweaning multisystemic wasting syndrome affected farms
Vaccine, 27(52), 7313–7321.
author keywords: Porcine circovirus type 2 (PCV2); Postweaning multisystemic wasting syndrome (PMWS); Vaccine
MeSH headings : Animals; Antibodies, Viral / blood; Circoviridae Infections / immunology; Circoviridae Infections / prevention & control; Circoviridae Infections / virology; DNA, Viral / isolation & purification; Female; Genetic Engineering; Male; Porcine Postweaning Multisystemic Wasting Syndrome / immunology; Porcine Postweaning Multisystemic Wasting Syndrome / prevention & control; Porcine Postweaning Multisystemic Wasting Syndrome / virology; Swine; Viral Load; Viral Vaccines / immunology; Viral Vaccines / therapeutic use
TL;DR:
This is the first time in which it is shown that a PCV2 vaccine is able to decrease specifically PMWS-associated mortality.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: February 11, 2019
2009 journal article
Chimeric calicivirus-like particles elicit protective anti-viral cytotoxic responses without adjuvant
Virology, 387(2), 303–312.
author keywords: RHDV virus-like particles; Dendritic cells; Vaccinia virus infection; Vaccine vector
MeSH headings : Adjuvants, Immunologic; Amino Acid Sequence; Animals; CD8-Positive T-Lymphocytes / immunology; Caliciviridae Infections / immunology; Chickens; Cytotoxicity Tests, Immunologic; Epitopes, T-Lymphocyte / genetics; Epitopes, T-Lymphocyte / metabolism; Female; Hemorrhagic Disease Virus, Rabbit / genetics; Hemorrhagic Disease Virus, Rabbit / immunology; Immunologic Memory; Injections, Intraperitoneal; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Ovalbumin / genetics; Ovalbumin / immunology; Reassortant Viruses / immunology; Reassortant Viruses / metabolism; T-Lymphocytes / immunology; T-Lymphocytes, Cytotoxic / immunology; Vaccination; Vaccinia / prevention & control; Vaccinia / virology; Vaccinia virus / genetics; Vaccinia virus / isolation & purification; Viral Vaccines / immunology; Virion / immunology; Virion / metabolism
TL;DR:
In vivo, mice immunized with the chimeric VLPs without adjuvant were able to induce specific cellular responses mediated by cytotoxic and memory T cells and immunization with chimeric RHDV-VLPs was able to resolve an infection by a recombinant vaccinia virus expressing OVA protein.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: February 11, 2019
2009 article
Effect of treatment with phytosterols in three herds with porcine respiratory disease complex.
LorenzoJ, F., Elisa, C., Joan, W., Montse, A., Lorenzo, M., Lara, R., … María, M. (2009, January). Journal of Swine Health and Production, Vol. 17, pp. 32–41, http://europepmc.org/abstract/AGR/IND44168201
Source: ORCID
Added: February 11, 2019
2009 journal article
Interferon-gamma induction correlates with protection by DNA vaccine expressing E2 glycoprotein against classical swine fever virus infection in domestic pigs.
Veterinary Microbiology, 142(1-2), 51–58.
author keywords: Classical swine fever virus; DNA vaccines; Interferon-gamma; Protection
MeSH headings : Animals; Antibodies, Viral / blood; Cell Line; Classical Swine Fever / immunology; Classical Swine Fever / prevention & control; Classical Swine Fever Virus / immunology; Interferon-gamma / immunology; Swine; Time Factors; Vaccines, DNA / immunology; Viral Envelope Proteins / immunology; Viral Vaccines / immunology
TL;DR:
P pigs vaccinated with the DNA vaccine induced a strong cellular immune response, characterized by the specific induction IFN-gamma expressing T cells after vaccination without any detectable levels of CSFV neutralizing antibodies, which supports the relevance of the induction of a strong T cellular response to confer a solid protection upon DNA vaccination against CSfV.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: February 11, 2019
2008 conference paper
IMMUNOMODULATION IN PRRS MLV VACCINATION
20th INTERNATIONAL PIG VETERINARY SOCIETY CONGRESS, 21.
Source: ORCID
Added: February 11, 2019
2008 conference paper
Suvaxyn® Circo ameliorates PCV2-associated lymphoid lesions and PMWS-associated mortality
20th INTERNATIONAL PIG VETERINARY SOCIETY CONGRESS, 18.
Source: ORCID
Added: February 11, 2019
2007 journal article
A proposal on porcine circovirus type 2 (PCV2) genotype definition and their relation with postweaning multisystemic wasting syndrome (PMWS) occurrence.
Veterinary Microbiology, 128(1-2), 23–35.
author keywords: porcine circovirus type 2 (PCV2); postweaning multisystemic wasting syndrome (PMWS); genotype; phylogeny; epidemiology; pathogenicity
MeSH headings : Amino Acid Sequence; Animal Husbandry; Animals; Base Sequence; Circoviridae Infections / veterinary; Circoviridae Infections / virology; Circovirus / classification; Circovirus / genetics; Circovirus / pathogenicity; DNA, Viral / genetics; Genotype; Molecular Sequence Data; Phylogeny; Porcine Postweaning Multisystemic Wasting Syndrome / virology; Sequence Alignment; Sequence Homology, Nucleic Acid; Swine
TL;DR:
Results suggest that PCV2 genotype 1 may potentially be more pathogenic than PCV 2 genotype 2 and infection of single pigs from PMWS affected farms harbouring both genotypes is described.
(via Semantic Scholar)
Source: ORCID
Added: February 11, 2019
Employment
Updated: October 15th, 2019 16:01
2018 - present
North Carolina State University Raleigh, NC, US
Assistant Professor
Population Health and Pathobiology
2017 - 2018
INRA Centre de Jouy-en-Josas Jouy-en-Josas, Île-de-France, FR
Post doc
GABI, VIM
2015 - 2016
Linköpings Universitet Institutionen för klinisk och experimentell medicin Linkoping, Region Östergötland, SE
Postdoctoral scientist
Molecular Virology
2015 - 2015
Universitetssjukhuset i Linköping Linkoping, Region Östergötland, SE
Technician
Clinical immunology and transfusion medicine
2013 - 2015
Linköpings Universitet Institutionen för klinisk och experimentell medicin Linköping, SE
Post Doc
Molecular Virology
2012 - 2012
CRESA Bellaterra, Catalunya, ES
Post Doc
2007 - 2011
CRESA Bellaterra, Catalunya, ES
PhD
2011 - 2011
Walter and Eliza Hall Institute of Medical Research Melbourne, VIC, AU
Visiting PhD student
Inflammation division
2010 - 2010
CISA-INIA Madrid, ES
Visiting PhD student
CISA
2009 - 2009
Universiteit Gent Gent, BE
Visiting PhD student
Faculty of Veterinary Medicine, Virology lab.
2008 - 2008
University of Aberdeen Aberdeen, Aberdeen, GB
Visiting PhD student
Institute of Medical Science
2007 - 2007
CRESA Bellaterra, Catalunya, ES
Master Student
Education
Updated: February 8th, 2023 15:46
2023 - 2026
USDA Veterinary Services Washington, DC, US
National Veterinary Accreditation (US)
2020 - 2021
North Carolina State University Raleigh, North Carolina, US
Inclusive Excellence program Certificate
2019 - 2019
North Carolina State University Raleigh, North Carolina, US
Reflective Educational Design (RED) Core Teaching Certification (CTC)
2007 - 2011
Universitat Autònoma de Barcelona Bellaterra, Catalunya, ES
PhD in Animal Health and Medicine with Special Award
CRESA
2006 - 2007
Universitat Autònoma de Barcelona Bellaterra, Catalunya, ES
Master of Science in Veterinary research
Veterinary faculty
1997 - 2005
Facolta di Medicina Veterinaria Bologna, Emilia-Romagna, IT
DVM with honors degree
Funding History
Funding history based on the linked ORCID record. Updated: September 19th, 2024 14:56
grant
July 1, 2022 - June 1, 2026
Predict and Protect against PRRSV: Combine PRRSV forecasting technology with vaccine efficacy prediction to prevent PRRSV outbreaks
National Institute of Food and Agriculture (USDA)
grant
November 1, 2020 - November 1, 2025
Maternal Influenza Vaccination for Generation of HA-Specific Neutralizing sIgA Antibodies in Breast Milk
Bill and Melinda Gates Foundation
grant
August 18, 2020 - September 30, 2021
Potential of PRP as antiviral therapeutics in pigs
National Institute of Food and Agriculture
grant
November 19, 2019 - June 30, 2021
IMMUNOGENOMICS OF PORCINE LUNG CELLS DURING PRRSV-2 INFECTION
National Institute of Food and Agriculture
grant
June 1, 2019 - June 1, 2021
Define Long Non-coding RNA Regulatory Mechanisms of Host Response to Influenza Infection
NIAID Bioinformatics Research Center
contract
January 1, 2019 - January 1, 2021
Heterologous Cross-Lineage Immunogenicity and Efficacy of Prevacent
Elanco Animal Health
grant
January 1, 2019 - January 1, 2020
Understanding Porcine Respiratory Disease Complex and How to Prevent It
North Carolina Pork Council
salary-award
September 1, 2017 - January 1, 2018
P.I.G. Pig Immunity Genomics
European Commission
award
April 1 - July 1, 2011
Dendritic cells techniques
Ministerio de Ciencia e Innovación
award
February 1 - May 1, 2010
Virus like particle production
Ministerio de Ciencia e Innovación
award
March 1 - July 1, 2009
Influenza virus techniques
Ministerio de Ciencia e Innovación
award
June 1 - August 1, 2008
Laser microdissection tecnique
Secretaría Nacional de Ciencia, Tecnología e Innovación
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