Works (5)
Updated: July 5th, 2023 15:45
2017 journal article
A Cytoplasmic RNA Virus Alters the Function of the Cell Splicing Protein SRSF2
JOURNAL OF VIROLOGY, 91(7).
author keywords: RNA processing; SRSF; reovirus; splicing
MeSH headings : Active Transport, Cell Nucleus; Amino Acid Sequence; Animals; Cell Nucleus / virology; Cytoplasm / virology; HEK293 Cells; Humans; Mice; Microtubules / metabolism; Orthoreovirus, Mammalian / physiology; Protein Binding; Protein Multimerization; RNA Splicing; RNA, Messenger / genetics; RNA, Messenger / metabolism; Serine-Arginine Splicing Factors / physiology; Viral Proteins / metabolism; Virus Replication
TL;DR:
It is demonstrated here that some mammalian reoviruses, RNA viruses that replicate strictly in the cytoplasm, express a protein variant that localizes to nuclear speckles, where it targets a cell mRNA splicing factor.
(via Semantic Scholar)
open access via jvi.asm.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Spontaneous activation of a MAVS-dependent antiviral signaling pathway determines high basal interferon-beta expression in cardiac myocytes
Journal of Molecular and Cellular Cardiology, 111, 102–113.
MeSH headings : Adaptor Proteins, Signal Transducing / metabolism; Aging / metabolism; Animals; Antiviral Agents / metabolism; Female; Fibroblasts / metabolism; Fibroblasts / virology; Interferon-Induced Helicase, IFIH1 / metabolism; Interferon-beta / metabolism; Mammalian orthoreovirus 3 / physiology; Mice, Inbred C57BL; Mitochondria / metabolism; Mitochondrial Proteins / metabolism; Muscle Fibers, Skeletal / metabolism; Myocardium / metabolism; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / virology; Peroxisomes / metabolism; Protein Serine-Threonine Kinases / metabolism; Repressor Proteins / metabolism; Signal Transduction
TL;DR:
It is demonstrated here that the mitochondrial antiviral signaling (MAVS) pathway is spontaneously activated in unstimulated cardiac myocytes but not cardiac fibroblasts or skeletal muscle cells, and results provide the first mechanism for spontaneous high expression of the antiviral cytokine IFN-β in a poorly replenished and essential cell type.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
NF-kappa B activation is cell type-specific in the heart
VIROLOGY, 502, 133–143.
author keywords: NF-kappa B; Myocarditis; Cardiac myocyte; Cardiac fibroblast; Cardiomyocyte; Golgi; Reovirus; Heart
MeSH headings : Animals; Cell Line; Cells, Cultured; Fibroblasts / metabolism; Fibroblasts / virology; Golgi Apparatus / metabolism; Golgi Apparatus / virology; Heart / virology; Humans; Mammalian orthoreovirus 3 / physiology; Mice; Mice, Inbred C57BL; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / virology; NF-kappa B / genetics; NF-kappa B / metabolism; Organ Specificity; Reoviridae Infections / genetics; Reoviridae Infections / metabolism; Reoviridae Infections / virology; Signal Transduction
TL;DR:
Results indicate that NF-κB-dependent signaling in the heart is cardiac cell type-specific, likely reflecting mechanisms that have evolved to balance responses that can be either protective or damaging to the heart.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
An ITAM in a Nonenveloped Virus Regulates Activation of NF- B, Induction of Beta Interferon, and Viral Spread
Journal of Virology, 88(5), 2572–2583.
MeSH headings : Amino Acid Sequence; Animals; Cell Line; Enzyme Activation; Humans; Immunoreceptor Tyrosine-Based Activation Motif; Interferon-beta / metabolism; Intracellular Signaling Peptides and Proteins / metabolism; Mice; Molecular Sequence Data; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / virology; NF-kappa B / metabolism; Phosphorylation; Protein Binding; Protein-Tyrosine Kinases / metabolism; Reoviridae / pathogenicity; Reoviridae / physiology; Sequence Alignment; Syk Kinase; Tyrosine / metabolism; Viral Proteins / chemistry; Viral Proteins / metabolism; Viral Tropism
TL;DR:
It is demonstrated for the first time that μ2 is phosphorylated, contains a functional ITAM, and activates NF-κB, and the results suggest that the cell type-specific effect of the μ2 ITAM on viral spread reflects the celltype-specific effects of NF-β and IFN-β.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2012 journal article
A Small Molecule Inhibitor Partitions Two Distinct Pathways for Trafficking of Tonoplast Intrinsic Proteins in Arabidopsis
PLOS ONE, 7(9).
Contributors: n, M. Rodriguez-Welsh n, G. Hicks * & M. Rojas-Pierce n
Ed(s): E. Damme
MeSH headings : Acyltransferases / genetics; Acyltransferases / physiology; Aquaporins / genetics; Aquaporins / physiology; Arabidopsis / drug effects; Arabidopsis / metabolism; Arabidopsis Proteins / genetics; Arabidopsis Proteins / metabolism; Arabidopsis Proteins / physiology; Brefeldin A / pharmacology; Cell Membrane / metabolism; Golgi Apparatus / metabolism; Green Fluorescent Proteins / metabolism; Hypocotyl / metabolism; Microscopy, Confocal / methods; Models, Biological; Promoter Regions, Genetic; Protein Transport; Seedlings; Vacuoles / metabolism
TL;DR:
It is shown that members of the TIP family are targeted to the vacuole via at least two distinct pathways, and the bioactivity of a novel inhibitor that can differentiate between them is characterized and mediated in part by common mechanisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
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