Works (56)

Updated: April 3rd, 2024 17:33

2023 article

Editorial: Women in psychiatry 2022: Addictive disorders

Lynch, W. J., Towers, E. B., & Rissman, E. F. (2023, April 11). FRONTIERS IN PSYCHIATRY, Vol. 14.

By: W. Lynch*, E. Towers* & E. Rissman n

author keywords: substance use disorder; women; opioids; editorial; gender bias
TL;DR: This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). (via Semantic Scholar)
Source: Web Of Science
Added: May 15, 2023

2023 article

Role of hormones in substance use disorders

Rissman, E. F., & Lynch, W. J. (2023, August 10). NEUROENDOCRINOLOGY.

By: E. Rissman* & W. Lynch*

TL;DR: A group of primary-literature papers solicited from many of the leading addiction laboratories in the world are assembled, highlighting different drug classes, hormones, levels of analysis, and animal models in the hope that this “ wide angle ” approach provides some overarching conclusions on common mechanisms. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: September 5, 2023

2023 article

Sex chromosome complement and estradiol modify cocaine self-administration behaviors in male mice

Le, A. L., Lynch, W. J., & Rissman, E. (2023, June 22). NEUROENDOCRINOLOGY.

By: A. Le*, W. Lynch* & E. Rissman*

TL;DR: The results suggest that in gonadal male mice, SCC and estradiol can modulate the reinforcing effects of cocaine which may influence the likelihood of cocaine use. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: July 24, 2023

2022 journal article

Fentanyl-induced acute and conditioned behaviors in two inbred mouse lines: Potential role for Glyoxalase

PHYSIOLOGY & BEHAVIOR, 243.

By: S. Harp n, M. Martini n, W. Rosenow*, L. Mesner*, H. Johnson n, C. Farber*, E. Rissman n

author keywords: RNA-sequencing; Opioids; Metabolism; Fentanyl; Conditioned place preference; Acute activity; Conditioned activity
MeSH headings : Animals; COVID-19; Fentanyl / pharmacology; Humans; Mice; Mice, Inbred C57BL; Pandemics; SARS-CoV-2
TL;DR: Interestingly, few differentially expressed genes were noted using treatment as the main factor, however many genes differed between strains, and it is suggested that future studies assess the ability of Glo1 and related metabolites to modify opioid intake. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: November 29, 2021

2020 journal article

Bisphenol A Exposure in utero Disrupts Hypothalamic Gene Expression Particularly Genes Suspected in Autism Spectrum Disorders and Neuron and Hormone Signaling

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(9).

By: A. Henriksen*, A. Andrade*, E. Harris n, E. Rissman n & J. Wolstenholme*

author keywords: endocrine disruptor; bisphenol A; neurodevelopment; genomics; syntaxin 1a
MeSH headings : Air Pollutants, Occupational / adverse effects; Animals; Autism Spectrum Disorder / etiology; Autism Spectrum Disorder / metabolism; Benzhydryl Compounds / adverse effects; Computational Biology / methods; Databases, Genetic; Disease Models, Animal; Disease Susceptibility; Female; Gene Expression Profiling; Gene Expression Regulation / drug effects; Hormones / metabolism; Hypothalamus / drug effects; Hypothalamus / metabolism; Maternal Exposure / adverse effects; Mice; Neurons / drug effects; Neurons / metabolism; Phenols / adverse effects; Signal Transduction; Transcriptome
TL;DR: Gene ontology analysis indicated that those DEGs were overrepresented in categories relating to mating, cell–cell signaling, behavior, neurodevelopment, neurogenesis, synapse formation, cognition, learning behaviors, hormone activity, and signaling receptor activity, among others. (via Semantic Scholar)
Source: Web Of Science
Added: June 15, 2020

2020 review

Mini-review: Epigenetic mechanisms that promote transgenerational actions of endocrine disrupting chemicals: Applications to behavioral neuroendocrinology

[Review of ]. HORMONES AND BEHAVIOR, 119.

By: M. Martini n, V. Corces* & E. Rissman n

author keywords: Chromatin; Transcription factors; CTCF; Transgenerational; Endocrine disrupting chemicals; Methylation; Bisphenol; PCB; Vinclozolin; Phthalates; Estrogen; Androgen
MeSH headings : Animals; Behavior / drug effects; Behavioral Research / methods; Behavioral Research / trends; Cohort Effect; DNA Methylation / drug effects; Endocrine Disruptors / pharmacology; Environmental Exposure / analysis; Environmental Exposure / statistics & numerical data; Epigenesis, Genetic / drug effects; Epigenesis, Genetic / physiology; Female; Humans; Male; Nervous System / drug effects; Nervous System / embryology; Nervous System / growth & development; Neuroendocrinology / methods; Neuroendocrinology / trends; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / genetics; Prenatal Exposure Delayed Effects / physiopathology; Reproduction / drug effects; Sex Differentiation / drug effects
TL;DR: The literature on transgenerational actions of endocrine disrupting chemicals (EDCs) on brain and behavior and their underlying epigenetic mechanisms including: DNA methylation, histone modifications, and non-coding RNAs are examined. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: April 6, 2020

2020 journal article

Sex chromosome complement influences vulnerability to cocaine in mice

HORMONES AND BEHAVIOR, 125.

By: M. Martini n, J. Irvin n, C. Lee n, W. Lynch* & E. Rissman n

author keywords: Mice; Cocaine; Self-administration; Sex chromosomes; Locomotor activity; Sex differences; Addiction
MeSH headings : Animals; Behavior, Animal / drug effects; Cocaine / pharmacology; Cocaine-Related Disorders / genetics; Estradiol / physiology; Female; Genetic Predisposition to Disease; Genotype; Gonads / physiology; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Sex Characteristics; Sex Chromosomes / physiology
TL;DR: The data demonstrate that sex chromosome complement alone and/or interacting with gonadal status can modify cocaine's reinforcing and locomotor-activating effects and inform current studies of sex differences in drug use. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: November 9, 2020

2020 review

Sexual Differentiation and Substance Use: A Mini-Review

[Review of ]. ENDOCRINOLOGY, 161(9).

By: S. Harp n, M. Martini n, W. Lynch* & E. Rissman n

author keywords: cocaine; sexual differentiation; mice; sex chromosomes; dopamine; estrogen
MeSH headings : Aging / drug effects; Aging / physiology; Animals; Brain / drug effects; Brain / physiology; Gonadal Steroid Hormones / pharmacology; Humans; Reward; Risk Factors; Sex Characteristics; Sex Differentiation / physiology; Sex Factors; Substance-Related Disorders / epidemiology; Substance-Related Disorders / etiology
TL;DR: It is proposed that sex chromosome complement also plays a role in determining sex-specific drug-taking behavior and the four core genotypes mouse model is proposed as an effective tool for answering these questions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: September 28, 2020

2019 journal article

Bisphenol F has different effects on preadipocytes differentiation and weight gain in adult mice as compared with Bisphenol A and S

TOXICOLOGY, 420, 66–72.

author keywords: Bisphenol; Metabolism; Fat; BPF; Alternatives to BPA; Diabetes
MeSH headings : 3T3-L1 Cells; Adipocytes / drug effects; Adipocytes / metabolism; Adipogenesis / drug effects; Adipogenesis / genetics; Animals; Benzhydryl Compounds / toxicity; Dose-Response Relationship, Drug; Endocrine Disruptors / toxicity; Gene Expression Regulation; Male; Mice; Mice, Inbred ICR; Phenols / toxicity; Sulfones / toxicity; Time Factors; Weight Gain / drug effects
TL;DR: The results suggest that BPS has a strong potential to be obesogenic while effects of BPF are subtler and potentially in the opposite direction. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: June 17, 2019

2019 journal article

Transgenerational Bisphenol A Causes Deficits in Social Recognition and Alters Postsynaptic Density Genes in Mice

ENDOCRINOLOGY, 160(8), 1854–1867.

By: J. Wolstenholme*, Z. Drobna n, A. Henriksen*, J. Goldsby*, R. Stevenson*, J. Irvin n, J. Flaws*, E. Rissman n

MeSH headings : Animals; Benzhydryl Compounds / toxicity; Brain / drug effects; Brain / metabolism; Female; Fetus / drug effects; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins / physiology; Phenols / toxicity; Post-Synaptic Density / drug effects; Social Behavior
TL;DR: Transgenerational BPA exposure disrupted social interactions in mice and dysregulated normal expression of PSD genes during neural development, suggesting that BPA may contribute, in a transgenerational manner, to neurodevelopmental diseases. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 19, 2019

2018 journal article

Effects of maternal or paternal bisphenol A exposure on offspring behavior

HORMONES AND BEHAVIOR, 101, 68–76.

By: E. Harris n, H. Allardice n, A. Schenk* & E. Rissman n

MeSH headings : Animals; Anxiety / chemically induced; Anxiety / physiopathology; Behavior, Animal / drug effects; Benzhydryl Compounds / pharmacology; Endocrine Disruptors / pharmacology; Female; Male; Maternal Exposure / adverse effects; Mice; Mice, Inbred C57BL; Paternal Exposure / adverse effects; Phenols / pharmacology; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / physiopathology; Sexual Behavior, Animal / drug effects
TL;DR: These are among the first studies conducted to ask if BPA exposure via the sire affects offspring behavior and the first study to report effects of gestational BPA Exposure on pup USVs and adult operant responding. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Direct and transgenerational effects of low doses of perinatal di-(2-ethylhexyl) phthalate (DEHP) on social behaviors in mice

PLOS ONE, 12(2).

By: K. Quinnies*, E. Harris*, R. Snyder*, S. Sumner n & E. Rissman n

MeSH headings : Animals; Behavior, Animal / drug effects; Body Weight / drug effects; Chromatography, High Pressure Liquid; Diethylhexyl Phthalate / blood; Diethylhexyl Phthalate / metabolism; Diethylhexyl Phthalate / toxicity; Female; Male; Maternal Exposure; Maze Learning; Mice; Mice, Inbred C57BL; Models, Animal; Pregnancy; Prenatal Exposure Delayed Effects; Social Behavior
TL;DR: The generation-dependent effects on behavior and AGI suggest complex mechanisms by which DEHP directly impacts reproductive and neurobehavioral development and influences germline-inherited traits. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Multi- and transgenerational consequences of Bisphenol A on sexually dimorphic cell populations in mouse brain

Endocrinology, 158(1), 21–30.

By: J. Goldsby, J. Wolstenholme & E. Rissman

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Transgenerational Effects of Bisphenol A on Gene Expression and DNA Methylation of Imprinted Genes in Brain

ENDOCRINOLOGY, 159(1), 132–144.

By: Z. Drobna n, A. Henriksen*, J. Wolstenholme*, C. Montiel n, P. Lambeth*, S. Shang*, E. Harris*, C. Zhou* ...

MeSH headings : Animals; Benzhydryl Compounds / toxicity; Brain / drug effects; Brain / metabolism; Crosses, Genetic; DNA Methylation / drug effects; Endocrine Disruptors / toxicity; Epigenesis, Genetic / drug effects; Female; Fetal Development / drug effects; Gene Expression Regulation, Developmental / drug effects; Hypothalamus, Anterior / drug effects; Hypothalamus, Anterior / metabolism; Lactation; Male; Maternal Exposure / adverse effects; Mice, Inbred Strains; Neurons / drug effects; Neurons / metabolism; Phenols / toxicity; Pregnancy; Preoptic Area / drug effects; Preoptic Area / metabolism; RNA, Long Noncoding / agonists; RNA, Long Noncoding / genetics; RNA, Long Noncoding / metabolism; Random Allocation; Septal Nuclei / drug effects; Septal Nuclei / metabolism; Sex Characteristics
TL;DR: This gene, maternally expressed gene 3 (Meg3), has been associated with EDCs and neurobehavioral phenotypes and may be a biomarker indicative of early life environmental perturbation. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Inheritance of steroid-independent male sexual behavior in male offspring of B6D2F1 mice

HORMONES AND BEHAVIOR, 80, 132–138.

author keywords: Steroid-independent male sexual behavior; B6D2F1 mouse; Behavioral genetics; APP; Tau; Synaptophysin
MeSH headings : Amyloid beta-Protein Precursor / genetics; Animals; Female; Gene Expression / genetics; Gonadal Steroid Hormones / physiology; Humans; Male; Mice; Mice, Inbred Strains; Phenotype; Preoptic Area / physiology; Sexual Behavior; Sexual Behavior, Animal / physiology; Steroids; Synaptophysin / genetics; tau Proteins / genetics
TL;DR: The specific goals of this study were to determine whether steroid-independent male sexual behavior was a heritable trait by determining if it was dependent upon the behavioral phenotype of the B6D2F1 sire, and whether the differential expression of APP, tau, and synaptophysin in the medial preoptic area was similar to those found in their male offspring. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2016 article

The Endocrine Society Centennial: No Longer a Surprise: Estrogenic Chemicals in a Multitude of Places

Rissman, E. F. (2016, August). ENDOCRINOLOGY, Vol. 157, pp. 2969–2971.

By: E. Rissman n

MeSH headings : Animals; Endocrine Disruptors / isolation & purification; Endocrine Disruptors / pharmacology; Endocrinology / organization & administration; Endocrinology / trends; Environmental Exposure / analysis; Environmental Pollutants / isolation & purification; Environmental Pollutants / pharmacology; Estrogens / isolation & purification; Estrogens / pharmacology; History, 20th Century; History, 21st Century; Humans; MCF-7 Cells; Societies, Medical / history; Societies, Medical / organization & administration; Societies, Medical / trends
TL;DR: The scientific study of endocrine-disrupting chemicals is relatively new: a recent PubMed search found a total of 6184 hits for the term, 739 articles in 2015 as compared with 4, 20 years ago in 1995. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Immune Deficiency Influences Juvenile Social Behavior and Maternal Behavior

BEHAVIORAL NEUROSCIENCE, 129(3), 331–338.

By: K. Quinnies*, K. Cox* & E. Rissman*

author keywords: immunodeficiency; social recognition; maternal behavior; SCID; sex differences
MeSH headings : Animals; Animals, Newborn; Behavior, Animal / physiology; Disease Models, Animal; Female; Gene-Environment Interaction; Habituation, Psychophysiologic / physiology; Immunologic Deficiency Syndromes / psychology; Immunologic Deficiency Syndromes / therapy; Male; Maternal Behavior / physiology; Mice, Inbred C57BL; Mice, SCID; Ovariectomy; Perception / physiology; Psychological Tests; Random Allocation; Recognition, Psychology / physiology; Social Behavior; Spleen / cytology; Spleen / transplantation
TL;DR: The data indicate that Gene × Environment interactions influence social interactions in immune deficient mice and that partial immune restoration could normalize behaviors. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Neural growth hormone: regional regulation by estradiol and/or sex chromosome complement in male and female mice

BIOLOGY OF SEX DIFFERENCES, 6.

By: K. Quinnies*, P. Bonthuis*, E. Harris*, S. Shetty* & E. Rissman n

author keywords: Growth hormone; Sex differences; Estradiol; Sex chromosomes; Hypothalamus; Cerebellum; Growth hormone-releasing hormone; Obesity
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Loss of estrogen-mediated immunoprotection underlies female gender bias in experimental Crohn’s-like ileitis

Mucosal Immunology, 7(5), 1255–1265.

By: W. Goodman*, R. Garg*, B. Reuter*, B. Mattioli*, E. Rissman* & T. Pizarro*

MeSH headings : Animals; Crohn Disease / drug therapy; Crohn Disease / immunology; Crohn Disease / physiopathology; Disease Models, Animal; Estrogens / pharmacology; Female; Flow Cytometry; Ileitis / drug therapy; Ileitis / physiopathology; Male; Mice; Sex Factors; T-Lymphocytes, Regulatory / drug effects
TL;DR: Hormone signaling influences the expansion and function of GALT Tregs in an ER-dependent manner and contributes to gender-based differences in experimental CD. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2014 journal article

Mouse model systems to study sex chromosome genes and behavior: Relevance to humans

Frontiers in Neuroendocrinology, 35(4), 405–419.

By: K. Cox*, P. Bonthuis* & E. Rissman*

author keywords: Klinefelter syndrome; Turner syndrome; Four core genotypes; Sex differences; Behavior; Sexual differentiation
MeSH headings : Animals; Behavior, Animal / physiology; Disease Models, Animal; Genes, sry / genetics; Humans; Mice; Sex Characteristics; Sex Chromosomes / genetics; Y Chromosome / genetics
TL;DR: It is concluded that many social and cognitive behaviors are modified by sex chromosome complement, and the implications for human research are discussed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: August 28, 2020

2014 journal article

Number of X-chromosome genes influences social behavior and vasopressin gene expression in mice

Psychoneuroendocrinology, 51, 271–281.

By: K. Cox*, K. Quinnies*, A. Eschendroeder*, P. Didrick*, E. Eugster* & E. Rissman*

author keywords: Turner syndrome; Klinefelter syndrome; Sexual differentiation; Sex differences; Social behavior; Anxiety; Social anxiety
MeSH headings : Amygdala / metabolism; Animals; Behavior, Animal / physiology; Child; Female; Gene Dosage; Gene Expression Regulation / genetics; Genes, X-Linked; Humans; Male; Mice; Social Behavior; Turner Syndrome / blood; Turner Syndrome / genetics; Vasopressins / genetics; Vasopressins / metabolism; X Chromosome / genetics
TL;DR: Novel findings link sex chromosome genes with social behavior via concentrations of AVP in brain, adding to the understanding of sex differences in neurobehavioral disorders. (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

2014 journal article

Reprint of: Policy decisions on endocrine disruptors should be based on science across disciplines: A response to Dietrich, et al.

Frontiers in Neuroendocrinology, 35(1), 2–5.

Source: Crossref
Added: August 28, 2020

2013 journal article

Aromatase Deletion Accelerates Female Experimental Abdominal Aortic Aneurysm Formation

Journal of Vascular Surgery, 58(4), 1146–1147.

Source: Crossref
Added: August 28, 2020

2013 journal article

Dietary phytoestrogens inhibit experimental aneurysm formation in male mice

Journal of Surgical Research, 188(1), 326–338.

author keywords: Phytoestrogen; Aortic aneurysm; Mouse AAA model; Aneurysm phenotype; Inflammatory cytokine; MMP
MeSH headings : Animals; Aorta, Abdominal / metabolism; Aorta, Abdominal / pathology; Aortic Aneurysm, Abdominal / pathology; Aortic Aneurysm, Abdominal / prevention & control; Cytokines / metabolism; Dietary Supplements; Female; Inflammation / diet therapy; Male; Matrix Metalloproteinase 9 / metabolism; Mice; Mice, Inbred C57BL; Phytoestrogens / blood; Phytoestrogens / therapeutic use
TL;DR: The results suggest that dietary phytoestrogens inhibit experimental aortic aneurysm formation in male mice via a reduction of the inflammatory response in the aorta wall. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2013 journal article

Reprint of: Policy decisions on endocrine disruptors should be based on science across disciplines: A response to Dietrich et al.

Hormones and Behavior, 65(2), 190–193.

MeSH headings : Animals; Endocrine Disruptors / toxicity; Humans
Source: Crossref
Added: August 28, 2020

2013 journal article

Transgenerational effects of prenatal bisphenol A on social recognition

Hormones and Behavior, 64(5), 833–839.

By: J. Wolstenholme*, J. Goldsby* & E. Rissman*

author keywords: Endocrine disrupting chemicals; Social recognition; Transgenerational inheritance; Attention deficit hyperactivity disorder; Autism; Epigenetics
MeSH headings : Animals; Benzhydryl Compounds / pharmacology; Endocrine Disruptors / pharmacology; Female; Male; Maternal Exposure; Mice; Mice, Inbred C57BL; Motor Activity / drug effects; Phenols / pharmacology; Pregnancy; Prenatal Exposure Delayed Effects / psychology; Recognition, Psychology / drug effects; Social Behavior
TL;DR: The results demonstrate that BPA exposure during gestation has long lasting, transgenerational effects on social recognition and activity in mice and show that B PA exposure has transGenerational actions on behavior and have implications for human neurodevelopmental behavioral disorders. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2012 journal article

Experience-facilitated improvements in pup retrieval; evidence for an epigenetic effect

Hormones and Behavior, 62(2), 128–135.

By: D. Stolzenberg*, J. Stevens* & E. Rissman*

author keywords: Maternal experience; Epigenetics; Sodium butyrate; HDAC inhibition; Oxytocin; CBP
MeSH headings : Animals; Animals, Newborn; Behavior, Animal / drug effects; Behavior, Animal / physiology; Butyrates / pharmacology; Epigenesis, Genetic / drug effects; Epigenesis, Genetic / physiology; Exploratory Behavior / drug effects; Exploratory Behavior / physiology; Female; Gene Expression Regulation / drug effects; Gene Expression Regulation / physiology; Histone Deacetylase Inhibitors / pharmacology; Learning / drug effects; Learning / physiology; Maternal Behavior / drug effects; Maternal Behavior / physiology; Mice; Mice, Inbred C57BL; Pregnancy
TL;DR: Experiences with infants suggest that experience induces high levels of maternal care via epigenetic modifications, which in turn change expression of genes that promote maternal care. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: August 28, 2020

2012 journal article

Running-induced epigenetic and gene expression changes in the adolescent brain

International Journal of Developmental Neuroscience, 31(6), 382–390.

By: J. Abel* & E. Rissman*

author keywords: Epigenetic; Exercise; Puberty; Adolescent; Cerebellum; BDNF
MeSH headings : Animals; Animals, Newborn; Brain / physiology; Epigenesis, Genetic / physiology; Epigenomics; Gene Expression / physiology; Histones; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins / metabolism; Neuronal Plasticity / physiology; Physical Conditioning, Animal; Signal Transduction / physiology
TL;DR: After 1 week of exercise, global acetylation of histone 3 was increased in both brain regions, Interestingly this was correlated with increased brain derived neural growth factor in the hippocampus, as noted in many other studies, but only a trend was found in cerebellum. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: August 28, 2020

2012 journal article

X-chromosome dosage affects male sexual behavior

Hormones and Behavior, 61(4), 565–572.

By: P. Bonthuis*, K. Cox* & E. Rissman*

author keywords: Klinefelter's Syndrome; Sex Chromosomes; Sexual differentiation; Masculine behavior; Aneuploid
MeSH headings : Aggression / physiology; Animals; Aromatase / biosynthesis; Copulation / physiology; Ejaculation / physiology; Estrogen Receptor alpha / biosynthesis; Female; Gene Dosage; Genitalia, Male / anatomy & histology; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Orchiectomy; Radioimmunoassay; Real-Time Polymerase Chain Reaction; Receptors, Androgen / biosynthesis; Septum of Brain / metabolism; Sex Characteristics; Sexual Behavior, Animal / physiology; Vasopressins / blood; X Chromosome / physiology
TL;DR: It is speculated that expression levels of a yet to be discovered gene(s) on the X-chromosome may affect sexual behavior in mice and perhaps in other mammals. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2011 journal article

Behavioral epigenetics: A new frontier in the study of hormones and behavior

Hormones and Behavior, 59(3), 277–278.

By: F. Champagne & E. Rissman*

MeSH headings : Animals; Behavior, Animal / physiology; Epigenesis, Genetic; Epigenomics / methods; Hormones / genetics
TL;DR: In this special issue of Hormones & Behavior, the diverse and innovative approaches to addressing this challenge of establishing the link between epigenetic effects, the experience of environmental variation, and the variety of phenotypic outcomes that emerge are highlighted. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2011 journal article

Location, location, location: Genetic regulation of neural sex differences

Reviews in Endocrine and Metabolic Disorders, 13(3), 151–161.

By: J. Abel* & E. Rissman*

author keywords: Sex chromosomes; Estrogen receptors; Calbindin-D28k; Tyrosine hydroxylase; Dopamine; Vasopressin; Sexually dimorphic; Cerebellum; Frontal cortex; Epigenetic
MeSH headings : Animals; Arginine Vasopressin / physiology; Calbindin 1; Calbindins; Epigenesis, Genetic; Estrogen Receptor alpha / physiology; Female; Humans; Male; Mice; Midline Thalamic Nuclei / physiology; Preoptic Area / physiology; Rats; Receptors, Steroid / genetics; S100 Calcium Binding Protein G / genetics; Septal Nuclei / physiology; Sex Characteristics; Sex Chromosomes / physiology; Sexual Behavior, Animal / physiology; Tyrosine 3-Monooxygenase / genetics; Vasopressins / genetics
TL;DR: The thrust is to examine genetic bases of sex differences and how the use of genetically modified models has advanced understanding of this topic, focusing on three proteins that have well described sexual dimorphisms; calbindin-D28k, a calcium binding protein, tyrosine hydroxylase, the rate limiting enzyme involved in dopamine synthesis and vasopressin, a neuropeptide with central and peripheral sites of action. (via Semantic Scholar)
Source: Crossref
Added: October 29, 2020

2011 journal article

NTP-CERHR expert panel report on the developmental toxicity of soy infant formula

Birth Defects Research Part B: Developmental and Reproductive Toxicology, 92(5), 421–468.

By: G. McCarver*, J. Bhatia, C. Chambers*, R. Clarke*, R. Etzel*, W. Foster*, P. Hoyer*, J. Leeder* ...

author keywords: endocrine disrupters; nutrition; safety assessment
MeSH headings : Animals; Female; Humans; Infant; Infant Formula / chemistry; Infant, Newborn; Isoflavones / adverse effects; Isoflavones / pharmacokinetics; Isoflavones / toxicity; Male; Mice; Phytoestrogens / adverse effects; Phytoestrogens / pharmacokinetics; Phytoestrogens / toxicity; Rats; Soy Foods / adverse effects; Soybean Proteins / chemistry; Soybean Proteins / pharmacology; Soybean Proteins / toxicity
TL;DR: This updated evaluation of soy infant formula does not include an assessment on the potential reproductive toxicity of genistein following exposures during adulthood as was carried out in the 2006 evaluation, and focuses only on Soy infant formula and the potential developmental toxicity of its major isoflavone components. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2010 journal article

Critical periods of susceptibility to short-term energy challenge during pregnancy: Impact on fertility and offspring development

Physiology & Behavior, 99(1), 100–108.

By: A. Kauffman*, K. Bojkowska* & E. Rissman*

author keywords: Reproduction; Pregnancy; Fertility; Gestation; Delayed implantation; Energy balance; Food restriction; Sexual behavior; Development
MeSH headings : Analysis of Variance; Animals; Body Weight; Disease Susceptibility; Eating / physiology; Fasting / physiology; Female; Fertility / physiology; Fetal Development / physiology; Litter Size; Male; Nutritional Status; Pregnancy / physiology; Pregnancy Outcome; Pregnancy, Animal; Sexual Behavior, Animal; Shrews; Time Factors
TL;DR: There are critical periods of pregnancy, particularly after implantation, when short-term, mild energetic challenges have significant impacts on fertility and offspring postnatal development, and delayed implantation may have evolved, in part, as a buffering mechanism to prevent pregnancy failure during impaired energy balance in early gestation. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2010 journal article

Gestational exposure to bisphenol A and cross-fostering affect behaviors in juvenile mice

Hormones and Behavior, 58(5), 754–761.

By: K. Cox*, J. Gatewood*, C. Howeth* & E. Rissman*

author keywords: Endocrine disruptive compounds; Estrogens; Epigenetic; Environment; Methylation; Sex differences; Bisphenol A
MeSH headings : Air Pollutants / toxicity; Animal Husbandry; Animals; Animals, Newborn; Anxiety / chemically induced; Behavior, Animal / drug effects; Behavior, Animal / physiology; Benzhydryl Compounds; Exploratory Behavior / drug effects; Exploratory Behavior / physiology; Female; Male; Maternal Deprivation; Maternal Exposure / adverse effects; Maze Learning / drug effects; Maze Learning / physiology; Mice; Mice, Inbred C57BL; Phenols / toxicity; Pregnancy; Prenatal Exposure Delayed Effects / physiopathology; Prenatal Exposure Delayed Effects / psychology
TL;DR: The results show that prenatal BPA exposure affects social behavior and anxiety in the EPM, and some facet(s) of the infant-maternal interaction may modify these effects. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2010 journal article

Of mice and rats: Key species variations in the sexual differentiation of brain and behavior

Frontiers in Neuroendocrinology, 31(3), 341–358.

By: P. Bonthuis*, K. Cox*, B. Searcy*, P. Kumar*, S. Tobet* & E. Rissman*

author keywords: Hypothalamus; Calbindin D28k; Progestin receptor; Estrogen receptor; Nitric oxide; Sexual dimorphism
MeSH headings : Animals; Behavior, Animal / physiology; Brain / growth & development; Brain / physiology; Humans; Mice; Models, Animal; Rats; Sex Differentiation / physiology; Sexual Behavior, Animal / physiology; Species Specificity
TL;DR: Neural and behavioral sexual dimorphisms in rats and mice are reviewed, which highlight species differences and experimental gaps in the literature, that are needed for direct species comparisons. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2010 journal article

The role of Bisphenol A in shaping the brain, epigenome and behavior

Hormones and Behavior, 59(3), 296–305.

author keywords: Bisphenol A; Epigenetics; Social behavior; DNA methylation; Endocrine disrupting compound
MeSH headings : Animals; Behavior, Animal / drug effects; Benzhydryl Compounds; Brain / drug effects; Epigenesis, Genetic / drug effects; Estrogens, Non-Steroidal / pharmacology; Female; Humans; Learning / drug effects; Maternal Behavior / drug effects; Phenols / pharmacology; Pregnancy; Prenatal Exposure Delayed Effects; Sex Characteristics
TL;DR: An updated review of BPA's action on the brain and behavior is presented, discussing its role as both an endocrine active compound and an agent that alters DNA methylation. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2009 journal article

Androgen- and estrogen-independent regulation of copulatory behavior following castration in male B6D2F1 mice

Hormones and Behavior, 56(2), 254–263.

By: J. Park*, P. Bonthuis*, A. Ding*, S. Rais* & E. Rissman*

author keywords: Male copulatory behavior; Sexual behavior; Partner preference; B6D2F1 hybrid mice; Libido; Androgen receptors; Aromatase; Estrogen receptors
MeSH headings : Androgen Antagonists / pharmacology; Androgen Receptor Antagonists; Androgens / metabolism; Animals; Aromatase / metabolism; Aromatase Inhibitors / pharmacology; Copulation / drug effects; Copulation / physiology; Estradiol / analogs & derivatives; Estradiol / pharmacology; Estrogen Antagonists / pharmacology; Estrogen Receptor alpha / antagonists & inhibitors; Estrogen Receptor alpha / metabolism; Estrogens / metabolism; Female; Flutamide / pharmacology; Fulvestrant; Letrozole; Male; Mating Preference, Animal / drug effects; Mating Preference, Animal / physiology; Mice; Nitriles / pharmacology; Orchiectomy; Preoptic Area / drug effects; Preoptic Area / physiology; RNA, Messenger / metabolism; Receptors, Androgen / metabolism; Septal Nuclei / drug effects; Septal Nuclei / physiology; Triazoles / pharmacology
TL;DR: It is suggested that non-gonadal androgens and estrogens do not maintainCopulatory behavior in B6D2F1 mice which display copulatory behavior after castration, and this preference persisted after long-term castration in persistent copulators. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2009 journal article

Regulation of progestin receptors in medial amygdala: Estradiol, phytoestrogens and sex

Physiology & Behavior, 97(2), 146–150.

By: A. Kudwa*, N. Harada*, S. Honda* & E. Rissman*

author keywords: Phytoestrogens; Environmental estrogens; Endocrine disrupting compounds; Progestin receptor; Medial amygdala; Sex differences; Sexual differentiation; Soy
MeSH headings : Amygdala / cytology; Amygdala / metabolism; Analysis of Variance; Animals; Aromatase / deficiency; Castration / methods; Cell Count / methods; Estradiol / pharmacology; Estrogens / pharmacology; Female; Gene Expression Regulation / drug effects; Gene Expression Regulation / genetics; Gene Expression Regulation / physiology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons / drug effects; Neurons / metabolism; Phytoestrogens / pharmacology; Receptors, Progesterone / genetics; Receptors, Progesterone / metabolism
TL;DR: It is hypothesized that both aromatization of androgens to estrogens and dietary sources of additional estrogens are part of the normal requirement for sex differences in the rodent brain. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2008 journal article

Aggressive behaviors in adult SF-1 knockout mice that are not exposed to gonadal steroids during development.

Behavioral Neuroscience, 122(4), 876–884.

By: N. Grgurevic*, T. Büdefeld, E. Rissman*, S. Tobet & G. Majdic

author keywords: sexual differentiation; VMH; steroidogenic factor 1; sex steroids; aggression
MeSH headings : Adrenal Cortex Hormones / pharmacology; Adrenal Glands / transplantation; Age Factors; Aggression / drug effects; Aggression / physiology; Aging; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal / drug effects; Behavior, Animal / physiology; Castration / methods; Female; Male; Mice; Mice, Knockout; Sex Differentiation / drug effects; Sex Differentiation / physiology; Steroidogenic Factor 1 / deficiency
TL;DR: In the absence of sex steroid replacement, adult SF-1 KO mice were significantly more aggressive than control mice in tests with stimulus females, and after testosterone treatment, control males displayed significantly more aggression towards male intruders than control female mice. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: August 28, 2020

2008 journal article

Regulation of food intake by gonadotropin releasing hormone II in an animal model of binge eating disorder

Appetite, 51(2), 398.

By: J. Schneider* & E. Rissman*

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Crossref
Added: August 28, 2020

2008 journal article

Sex chromosome complement affects social interactions in mice

Hormones and Behavior, 54(4), 565–570.

By: A. Mcphielalmansingh*, L. Tejada*, J. Weaver* & E. Rissman*

author keywords: affective disorders; autism; depression; anxiety; sexual differentiation; X inactivation; cognition; pain
MeSH headings : Animals; Anxiety / genetics; Anxiety / physiopathology; Behavior, Animal / physiology; Disorders of Sex Development / genetics; Disorders of Sex Development / physiopathology; Disorders of Sex Development / veterinary; Feeding Behavior / physiology; Female; Genes, sry / physiology; Male; Mice; Mice, Inbred C57BL; Motor Activity / genetics; Motor Activity / physiology; Psychomotor Performance / physiology; Sex Chromosome Aberrations; Social Behavior; Y Chromosome
TL;DR: Data show that sex chromosome complement affects social interaction style in mice, and differences in circulating levels of gonadal steroids cannot account for these effects. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2007 journal article

Dietary phytoestrogens dampen female sexual behavior in mice with a disrupted aromatase enzyme gene.

Behavioral Neuroscience, 121(2), 356–361.

By: A. Kudwa*, W. Boon*, E. Simpson*, R. Handa* & E. Rissman*

author keywords: phytoestrogen; isoflavones; hypothalamus; sex differences; cyp19
MeSH headings : Animals; Aromatase / genetics; Aromatase / physiology; Diet; Estradiol / physiology; Female; Hypothalamus / physiology; Mice; Mice, Knockout; Orchiectomy; Ovariectomy; Phytoestrogens / pharmacology; Posture / physiology; Sexual Behavior, Animal / drug effects
TL;DR: The authors' findings suggest that dietary phytoestrogen consumption may partially defeminize adult female sexual behavior in the mouse. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2007 journal article

Diversity of actions of GnRHs mediated by ligand-induced selective signaling

Frontiers in Neuroendocrinology, 29(1), 17–35.

author keywords: GnRH; GnRH receptor; ligand-induced selective-signaling; reproduction; antiproliferation; GPCR; signal trafficking; cancer
MeSH headings : Amino Acid Sequence; Animals; Apoptosis / drug effects; Cell Proliferation / drug effects; Gene Silencing; Gonadotropin-Releasing Hormone / analogs & derivatives; Gonadotropin-Releasing Hormone / chemistry; Gonadotropin-Releasing Hormone / pharmacology; Gonadotropin-Releasing Hormone / physiology; Humans; Ligands; Models, Biological; Models, Molecular; Molecular Sequence Data; Neoplasms / pathology; Protein Isoforms / chemistry; Protein Isoforms / physiology; Receptors, LHRH / agonists; Receptors, LHRH / physiology; Reproductive Behavior / drug effects; Reproductive Behavior / physiology; Sequence Homology, Amino Acid; Sexual Behavior, Animal / drug effects; Sexual Behavior, Animal / physiology; Signal Transduction / drug effects; Signal Transduction / physiology; Structure-Activity Relationship; Substrate Specificity
TL;DR: It is proposed that the GnRH receptor can assume different conformations which have different selectivity for GnRH analogs and intracellular signaling proteins complexes and this ligand-induced selective-signaling recruits certain pathways while by-passing others and has implications in developing more selective Gn RH analogs for highly specific therapeutic intervention. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: August 28, 2020

2007 journal article

Neuronal nitric oxide synthase and calbindin delineate sex differences in the developing hypothalamus and preoptic area

Developmental Neurobiology, 67(10), 1371–1381.

By: M. Edelmann*, C. Wolfe, E. Scordalakes, E. Rissman* & S. Tobet

author keywords: sex differences; hypothalamus; preoptic area; nitric oxide; calbindin
MeSH headings : Animals; Biomarkers / analysis; Biomarkers / metabolism; Calbindins; Calcium-Binding Proteins / metabolism; Female; Hypothalamus / growth & development; Hypothalamus / metabolism; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins / metabolism; Neurons / metabolism; Nitric Oxide / biosynthesis; Nitric Oxide Synthase Type I / metabolism; Preoptic Area / growth & development; Preoptic Area / metabolism; Receptors, Androgen / metabolism; S100 Calcium Binding Protein G; Sex Characteristics; Sex Differentiation / physiology; Sexual Maturation / physiology
TL;DR: It is suggested that NO as an effector molecule and calbindin as a molecular biomarker illuminate key aspects of sexual differentiation in the developing mouse brain. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2007 journal article

Neuropeptide Y influences acute food intake and energy status affects NPY immunoreactivity in the female musk shrew (Suncus murinus)

Hormones and Behavior, 53(2), 342–350.

By: K. Bojkowska*, M. Hamczyk*, H. Tsai*, A. Riggan* & E. Rissman*

author keywords: obesity; anorexia; orexins; energy; feeding disorder; mating behavior; reproduction; gonadotropin releasing hormone; GnRH II
MeSH headings : Animals; Appetite Regulation / physiology; Brain / metabolism; Dose-Response Relationship, Drug; Energy Metabolism / physiology; Feeding Behavior / physiology; Female; Food Deprivation / physiology; Gonadotropin-Releasing Hormone / analogs & derivatives; Gonadotropin-Releasing Hormone / metabolism; Immunohistochemistry; Injections, Intraventricular; Neuropeptide Y / administration & dosage; Neuropeptide Y / physiology; Sexual Behavior, Animal / physiology; Shrews / metabolism; Tissue Distribution
TL;DR: It is hypothesize that interactions between NPY and GnRH II maintain energy homeostasis and reproduction in the musk shrew. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2006 journal article

A model for hormone independent development of sex differences in brain and behavior

Frontiers in Neuroendocrinology, 27(1), 96–97.

By: G. Majdic*, T. Budefeld*, N. Grgurevic*, E. Rissman* & S. Tobet*

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: August 28, 2020

2006 journal article

Impairment of spatial learning by estradiol treatment in female mice is attenuated by estradiol exposure during development

Hormones and Behavior, 50(5), 693–698.

By: D. Imwalle*, H. Bateman, A. Wills, S. Honda, N. Harada & E. Rissman*

author keywords: hippocampus; sex differences; phytoestrogens; aromatase; estrogen receptors; Morris water maze; sexual differentiation
MeSH headings : Animals; Animals, Newborn; Aromatase / genetics; Diet; Estradiol / analogs & derivatives; Estradiol / pharmacology; Female; Male; Maze Learning / drug effects; Mice; Mice, Inbred C57BL; Mice, Knockout; Phytoestrogens / pharmacology; Spatial Behavior / drug effects
TL;DR: Exposure to estradiol during neonatal development can counteract the deleterious effects of EB on adult spatial learning, and female but not male ArKO mice showed impaired learning compared to WT littermates. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2006 journal article

New roles for estrogen receptor β in behavior and neuroendocrinology☆

Frontiers in Neuroendocrinology, 27(2), 217–232.

By: C. Bodo* & E. Rissman*

author keywords: sex differences; hypothalamic pituitary-gonadal axis; hypothalamic-pituitary-adrenal axis; sexual differentiation; serotonin; depression; anxiety; reproduction
MeSH headings : Aggression; Animals; Anxiety / physiopathology; Arousal / physiology; Behavior, Animal / physiology; Discrimination Learning / physiology; Estradiol / metabolism; Estrogen Receptor beta / physiology; Female; Hypothalamo-Hypophyseal System / physiology; Male; Mice; Mice, Knockout; Models, Animal; Pituitary-Adrenal System / physiology; Sex Differentiation / physiology
TL;DR: The data on functions of the estrogen receptor beta (ERbeta) in both behavior and neuroendocrinology are reviewed to suggest a unique function for ERbeta in sexual differentiation; its activation in male neonates may promote defeminization of sexual behavior. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2005 journal article

A previously uncharacterized role for estrogen receptor  : Defeminization of male brain and behavior

Proceedings of the National Academy of Sciences, 102(12), 4608–4612.

By: A. Kudwa*, C. Bodo*, J. Gustafsson* & E. Rissman*

author keywords: developmental neurobiology; neuroendocrinology; sexual differentiation
MeSH headings : Animals; Brain / physiology; Estrogen Receptor beta / deficiency; Estrogen Receptor beta / genetics; Estrogen Receptor beta / physiology; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Neurological; Orchiectomy; Sex Characteristics; Sexual Behavior, Animal / physiology; Smell / physiology; Testis / physiology
TL;DR: It is hypothesized that ERbeta is involved in defeminization of brain and behavior, and this aspect of ERbeta function may lead to developments in the understanding of neural-based sexually dimorphic human behaviors. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2005 journal article

Dopamine D5 receptor modulates male and female sexual behavior in mice

Psychopharmacology, 180(2), 206–214.

By: A. Kudwa*, E. Dominguez-Salazar*, D. Cabrera*, D. Sibley* & E. Rissman*

author keywords: sexual behavior; dopamine; conditioned place preference; drugs; motivation; knockout mice; reward; attention deficit hyperactivity disorder
MeSH headings : Animals; Apomorphine / pharmacology; Conditioning, Psychological; Estradiol / pharmacology; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Progesterone / pharmacology; Reward; Sexual Behavior, Animal
TL;DR: The work suggests that the D5 receptor mediates dopamine’s action on sexual behavior in both sexes, perhaps via a reward pathway. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (OpenAlex)
Source: Crossref
Added: August 28, 2020

2005 journal article

Effects of galanin-like peptide (GALP) on locomotion, reproduction, and body weight in female and male mice

Hormones and Behavior, 48(2), 141–151.

By: A. Kauffman*, J. Buenzle*, G. Fraley* & E. Rissman*

author keywords: sexual behavior; energy balance; motor control; coordination; exploration; luteinizing hormone; gonadotropin-releasing hormone
MeSH headings : Animals; Body Weight / drug effects; Energy Metabolism / drug effects; Female; Galanin-Like Peptide / pharmacology; Gonadotropin-Releasing Hormone / physiology; Injections, Intraventricular; Luteinizing Hormone / blood; Male; Mice; Mice, Inbred C57BL; Motor Activity / drug effects; Ovariectomy; Postural Balance / drug effects; Reproduction / drug effects; Sexual Behavior, Animal / drug effects; Stereotaxic Techniques
TL;DR: Data indicate that in female mice, GALP stimulates LH release via GnRH, and decreases body weight, motor control, and locomotor activity via Gn RH-independent pathways, and species-specific differences in the mechanism and/or location of GALp action in the brains of rats and mice are suggested. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2005 journal article

Roles of estrogen receptors α and β in differentiation of mouse sexual behavior

Neuroscience, 138(3), 921–928.

By: A. Kudwa*, V. Michopoulos*, J. Gatewood* & E. Rissman*

author keywords: sex differences; gender identity; estrogen receptor; lordosis; sexual orientation; development
MeSH headings : Animals; Estradiol / physiology; Estrogen Receptor alpha / physiology; Estrogen Receptor beta / physiology; Female; Gender Identity; Male; Mice; Sex Characteristics; Sexual Behavior, Animal / physiology; Testosterone / physiology
TL;DR: In sum, estradiol can have selective effects on distinct behavioral processes via selective interactions with its two receptors, estrogen receptor alpha and estrogen receptor beta. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2004 journal article

Background matters: the effects of estrogen receptor α gene disruption on male sexual behavior are modified by background strain

Hormones and Behavior, 46(4), 482–490.

By: E. Dominguez-Salazar*, H. Bateman* & E. Rissman*

author keywords: sexual behavior; estrogen receptor; inbred strains; knockout mice; testosterone; aggression; lordosis; olfaction; DBA; BALB/c; C57BL/6J
MeSH headings : Analysis of Variance; Animals; Copulation / physiology; Ejaculation / physiology; Estrogen Receptor alpha / genetics; Estrogen Receptor alpha / physiology; Female; Fertility / genetics; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains / genetics; Mice, Inbred Strains / physiology; Mice, Knockout / genetics; Mice, Knockout / physiology; Sex Factors; Sexual Behavior, Animal / physiology; Species Specificity; Testosterone / physiology
TL;DR: The data suggest that genetic background has dramatic effects on male sexual behavior and its dependence on the ERα gene. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2004 journal article

Lack of functional estrogen receptor β influences anxiety behavior and serotonin content in female mice

Physiology & Behavior, 84(1), 157–163.

By: D. Imwalle*, J. Gustafsson* & E. Rissman*

author keywords: SSRI; menopause; estrogen receptor; depression; anxiety; serotonin
MeSH headings : Analysis of Variance; Animals; Anxiety / genetics; Anxiety / metabolism; Anxiety / physiopathology; Behavior, Animal; Biogenic Monoamines / metabolism; Brain Chemistry / drug effects; Brain Chemistry / genetics; Chromatography, High Pressure Liquid / methods; Estradiol / pharmacology; Estrogen Receptor beta / deficiency; Estrogen Receptor beta / genetics; Exploratory Behavior / drug effects; Female; Genotype; Maze Learning / drug effects; Mice; Mice, Knockout; Ovariectomy / methods; Serotonin / metabolism; Time Factors
TL;DR: It is hypothesized that ERbeta is required during development to modulate the effects of estrogen on anxiety and catecholamine concentrations in female mouse brains in the absence of functional ERbeta. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: August 28, 2020

2004 journal article

Of mice and missing data: what we know (and need to learn) about male sexual behavior

Physiology & Behavior, 83(2), 217–232.

By: M. Burns-Cusato*, E. Scordalakes* & E. Rissman*

author keywords: androgen receptor; estrogen receptor; inbred strain; knockout; mice; medial preoptic area; masculinization
MeSH headings : Animals; Gonadal Steroid Hormones / physiology; Male; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Models, Animal; Rats; Receptors, Steroid / physiology; Sex Characteristics; Sexual Behavior, Animal / physiology; Species Specificity
TL;DR: The current knowledge about the sexual behavior of male mice, with an emphasis on hormonal bases of these behaviors, is summarized and suggestions are made for the standardization of experimental protocols used in investigations of the sexual physiology and behavior ofmale mice. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2004 journal article

Of mice and missing data: what we know (and need to learn) about male sexual behavior

Physiology & Behavior, 83(2), 217–232.

By: M. Burnscusato*, E. Scordalakes* & E. Rissman*

Source: Crossref
Added: August 28, 2020

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