@article{simon_russell_mondino_yang_case_anderson_whitley_griffith_gruen_olby_2024, title={A randomized, controlled clinical trial demonstrates improved owner-assessed cognitive function in senior dogs receiving a senolytic and NAD plus precursor combination}, volume={14}, ISSN={["2045-2322"]}, DOI={10.1038/s41598-024-63031-w}, abstractNote={Abstract Age-related decline in mobility and cognition are associated with cellular senescence and NAD + depletion in dogs and people. A combination of a novel NAD + precursor and senolytic, LY-D6/2, was examined in this randomized controlled trial. Seventy dogs with mild to moderate cognitive impairment were enrolled and allocated into placebo, low or full dose groups. Primary outcomes were change in cognitive impairment measured with the owner-reported Canine Cognitive Dysfunction Rating (CCDR) scale and change in activity measured with physical activity monitors. Fifty-nine dogs completed evaluations at the 3-month primary endpoint, and 51 reached the 6-month secondary endpoint. There was a significant difference in CCDR score across treatment groups from baseline to the primary endpoint (p = 0.02) with the largest decrease in the full dose group. No difference was detected between groups using in house cognitive testing. There were no significant differences between groups in changes in measured activity. The proportion of dogs that improved in frailty and owner-reported activity levels and happiness was higher in the full dose group than other groups, however this difference was not significant. Adverse events occurred equally across groups. All groups showed improvement in cognition, frailty, and activity suggesting placebo effect and benefits of trial participation. We conclude that LY-D6/2 improves owner-assessed cognitive function over a 3-month period and may have broader, but more subtle effects on frailty, activity and happiness as reported by owners.}, number={1}, journal={SCIENTIFIC REPORTS}, author={Simon, Katherine E. and Russell, Katharine and Mondino, Alejandra and Yang, Chin-Chieh and Case, Beth C. and Anderson, Zachary and Whitley, Christine and Griffith, Emily and Gruen, Margaret E. and Olby, Natasha J.}, year={2024}, month={May} }
 @article{munoz amezcua_jones_griffith_gruen_2024, title={Pilot Study on the Efficacy and Safety of Long-Term Oral Imepitoin Treatment for Control of (Thunder)Storm-Associated Noise Phobia/Noise Aversion in Dogs Using an Individualized-Dose Titration Approach}, volume={14}, ISSN={["2076-2615"]}, DOI={10.3390/ani14040545}, abstractNote={Imepitoin is a low-affinity partial agonist for benzodiazepine binding sites of gamma-aminobutyric acid receptors with anxiolytic effects. It has been shown to reduce anxiety during noise-related events in dogs when given at 30 mg/kg PO BID, although this dose was associated with ataxia and increased appetite in some cases. The objective of this study was to assess its safety and efficacy for storm anxiety when started at 10 mg/kg PO BID and titrated to effect up to 30 mg/kg PO BID during storm season. Significant decreases in anxiety scores were seen in weekly surveys and storm logs (SLs) at 10, 20 and 30 mg/kg PO BID. Serious adverse events (AEs) were not reported in any subject. Ataxia was the most commonly reported non-serious AE (14/33), followed by increased hunger (13/33). The frequency of AEs was higher in the 20 mg/kg PO BID group than in the 10 mg/kg group PO BID. No clinically significant changes were seen in lab work pre- and post-study. In conclusion, Imepitoin given during storm season at doses ranging from 10 to 30 mg/kg PO BID reduced clinical signs of fear and anxiety during storms for the dogs in this study. These findings support the use of an individually titrated dose.}, number={4}, journal={ANIMALS}, author={Munoz Amezcua, Ana C. and Jones, Jennifer M. and Griffith, Emily H. and Gruen, Margaret E.}, year={2024}, month={Feb} }
 @article{blake_griffith_pierce_levy_parker_huebner_2024, title={Tell your story: Metrics of success for academic data science collaboration and consulting programs}, volume={13}, ISSN={["2049-1573"]}, DOI={10.1002/sta4.686}, abstractNote={Measuring success plays a central role in justifying and advocating for a statistical or data science consulting or collaboration program (SDSP) within an academic institution. We present several specific metrics to report to targeted audiences to tell the story for success of a robust and sustainable program. While gathering such metrics includes challenges, we discuss potential data sources and possible practices for SDSPs to inform their own approaches. Emphasizing essential metrics for reporting, we also share the metric gathering and reporting practices of two programs in greater detail. New or existing SDSPs should evaluate their local environments and tailor their practice to gathering, analysing and reporting success metrics accordingly. This approach provides a strong foundation to use success metrics to tell compelling stories about the SDSP and enhance program sustainability. The area of success metrics provides ample opportunity for future research projects that leverage qualitative methods and consider mechanisms for adapting to the changing landscape of data science.}, number={2}, journal={STAT}, author={Blake, Mara Rojeski and Griffith, Emily and Pierce, Steven J. and Levy, Rachel and Parker, Micaela and Huebner, Marianne}, year={2024}, month={Jun} }
 @article{mondino_ludwig_menchaca_russell_simon_griffith_kis_lascelles_gruen_olby_2023, title={Development and validation of a sleep questionnaire, SNoRE 3.0, to evaluate sleep in companion dogs}, volume={13}, ISSN={["2045-2322"]}, DOI={10.1038/s41598-023-40048-1}, abstractNote={Abstract}, number={1}, journal={SCIENTIFIC REPORTS}, author={Mondino, A. and Ludwig, C. and Menchaca, C. and Russell, K. and Simon, K. E. and Griffith, E. and Kis, A. and Lascelles, B. D. X. and Gruen, M. E. and Olby, N. J.}, year={2023}, month={Aug} }
 @article{collins_mccallum_nordby_aggarwal_griffith_thomas_dunn_2023, title={Enrollment, Engagement, and Effectiveness of a Large-Scale Diabetes Prevention Program Using Synchronous Distance Technology}, volume={4}, ISSN={["2673-4540"]}, DOI={10.3390/diabetology4040051}, abstractNote={The Centers for Disease Control and Prevention (CDC) indicates that individuals with prediabetes are significantly less likely to develop type 2 diabetes if they participate in a lifestyle change program that results in at least 5% weight loss and 150 min of physical activity per week. The CDC recognizes distance learning as an effective delivery mode for lifestyle change programs to prevent type 2 diabetes. The purpose of this study was to assess enrollment, engagement, and effectiveness of a type 2 diabetes prevention program (DPP) using synchronous distance technology. Eat Smart, Move More, Prevent Diabetes (ESMMPD) is an intensive 12-month DPP delivered using synchronous distance technology. Throughout 26 lessons, participants focused on healthy eating, physical activity, and mindfulness behaviors. Study findings showed a significant decrease in A1C (−0.24 p < 0.0001). Weight loss averaged 5.66% for those who completed the program. Based on the Wilcoxon signed-rank test, participants demonstrated statistically significant changes in self-reported confidence in their ability to perform all 18 health-promoting behaviors assessed (p < 0.0001). Participation in the program also resulted in the adoption of health promoting behaviors. A DPP using synchronous distance technology is an effective delivery mode to help participants adopt healthy behaviors, increase physical activity, and achieve the weight loss necessary to prevent or delay the onset of type 2 diabetes.}, number={4}, journal={DIABETOLOGY}, author={Collins, Casey and McCallum, Erin and Nordby, Kelly and Aggarwal, Surabhi and Griffith, Emily and Thomas, Cathy and Dunn, Carolyn}, year={2023}, month={Dec}, pages={574–585} }
 @article{newsome_poore_harmon_shaeffer_talbott_fellner_griffith_2023, title={The Effects of Varying Levels of Cotton Gin Byproduct and Wet brewers' Grains on Growth Performance of Growing and Finishing Steers}, volume={101}, ISSN={["1525-3163"]}, DOI={10.1093/jas/skad281.345}, abstractNote={Abstract}, journal={JOURNAL OF ANIMAL SCIENCE}, author={Newsome, Madeline and Poore, Matt H. and Harmon, Deidre D. and Shaeffer, April D. and Talbott, Charlotte L. and Fellner, Vivek and Griffith, Emily H.}, year={2023}, month={Nov}, pages={289–290} }
 @article{enders_weed_griffith_muddiman_2022, title={Development and validation of a high resolving power absolute quantitative per- and polyfluoroalkyl substances method incorporating Skyline data processing}, volume={36}, ISSN={["1097-0231"]}, url={https://doi.org/10.1002/rcm.9295}, DOI={10.1002/rcm.9295}, abstractNote={RationaleThe ability to perform absolute quantitation and non‐targeted analysis on a single mass spectrometry instrument would be advantageous to many researchers studying per‐ and polyfluoroalkyl substances (PFAS). High‐resolution accurate mass (HRAM) instrumentation (typically deployed for non‐targeted work) carries several advantages over traditional triple quadrupole workflows when performing absolute quantitation. Processing this data using a vendor‐neutral software would promote collaboration for these environmental studies.}, number={11}, journal={RAPID COMMUNICATIONS IN MASS SPECTROMETRY}, author={Enders, Jeffrey R. and Weed, Rebecca A. and Griffith, Emily H. and Muddiman, David C.}, year={2022}, month={Jun} }
 @article{gates_cai_hu_han_griffith_burgener_hyland_zanno_2022, title={Estimating ancient biogeographic patterns with statistical model discrimination}, volume={9}, ISSN={["1932-8494"]}, url={https://doi.org/10.1002/ar.25067}, DOI={10.1002/ar.25067}, abstractNote={Abstract}, journal={ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY}, author={Gates, Terry A. and Cai, Hengrui and Hu, Yifei and Han, Xu and Griffith, Emily and Burgener, Landon and Hyland, Ethan and Zanno, Lindsay E.}, year={2022}, month={Sep} }
 @article{zurlinden_spano_griffith_bennett_2022, title={Impact of Classical Counterconditioning (Quiet Kennel Exercise) on Barking in Kenneled Dogs-A Pilot Study}, volume={12}, ISSN={["2076-2615"]}, DOI={10.3390/ani12020171}, abstractNote={Excessive barking is a major source of noise pollution in dog kennels and negatively impacts welfare. Because resources are often limited, minimizing barking in the simplest and most easily implementable way is imperative. This pilot study implemented a Quiet Kennel Exercise (QKE) that utilized classical counterconditioning to change the dogs’ negative emotional state (which can lead to barking) to a more positive emotional state. Therefore, barking motivation is reduced, so barking should decrease. This study aims to show proof of concept that decreasing barking through classical counterconditioning is effective. It was conducted in one ward of day-time boarding kennels at North Carolina State University College of Veterinary Medicine. Data was collected three times per day and included decibel readings, number of dogs present, and number of dogs barking during a 5-day initial baseline and 10-day intervention period. During baseline, people passing through the ward acted as they normally would. During intervention, passersby were asked to simply toss each dog a treat regardless of the dogs’ behaviors in the kennel. Descriptive results show improvement in maximum level of barking after QKE, fewer dogs barking over time, dogs barking less each time, and the most improvement noted in the afternoon.}, number={2}, journal={ANIMALS}, author={Zurlinden, Samantha and Spano, Stephany and Griffith, Emily and Bennett, Sara}, year={2022}, month={Jan} }
 @article{williams_gallardo-williams_griffith_bretz_2022, title={Investigating Meaningful Learning in Virtual Reality Organic Chemistry Laboratories}, volume={99}, ISSN={["1938-1328"]}, DOI={10.1021/acs.jchemed.1c00476}, abstractNote={Virtual reality (VR) lab experiences for organic chemistry were developed at NC State University as an accessibility tool for students who are unable to attend in-person laboratories due to disabilities, attendance challenges such as pregnancy or military deployment, or safety concerns. The resulting first-person VR experiences are immersive and realistic, with a virtual teaching assistant guiding the user along the steps required to complete the experiment, including feedback as needed. During the COVID pandemic, these laboratories replaced traditional face-to-face laboratories at NC State and several other universities. During the summer of 2020, we used the Meaningful Learning in the Laboratory Instrument (MLLI) to measure both the cognitive and affective dimensions of students' expectations of the virtual lab before the course and their experiences with virtual reality after completing the course. Students who completed virtual reality laboratories reported more positive affective experiences than they anticipated, including little frustration or confusion in the laboratory. © 2021 American Chemical Society and Division of Chemical Education, Inc.}, number={2}, journal={JOURNAL OF CHEMICAL EDUCATION}, author={Williams, Nicholas D. and Gallardo-Williams, Maria T. and Griffith, Emily H. and Bretz, Stacey Lowery}, year={2022}, month={Feb}, pages={1100–1105} }
 @article{mondino_wagner_russell_lobaton_griffith_gruen_lascelles_olby_2022, title={Static posturography as a novel measure of the effects of aging on postural control in dogs}, volume={17}, ISSN={["1932-6203"]}, url={http://dx.doi.org/10.1371/journal.pone.0268390}, DOI={10.1371/journal.pone.0268390}, abstractNote={Aging is associated with impairment in postural control in humans. While dogs are a powerful model for the study of aging, the associations between age and postural control in this species have not yet been elucidated. The aims of this work were to establish a reliable protocol to measure center of pressure excursions in standing dogs and to determine age-related changes in postural sway. Data were obtained from 40 healthy adult dogs (Group A) and 28 senior dogs (Group B) during seven trials (within one session of data collection) of quiet standing on a pressure sensitive walkway system. Velocity, acceleration, root mean square, 95% ellipse area, range and frequency revolve were recorded as measures of postural sway. In Group A, reliability was assessed with intraclass correlation, and the effect of morphometric variables was evaluated using linear regression. By means of stepwise linear regression we determined that root mean square overall and acceleration in the craniocaudal direction were the best variables able to discriminate between Group A and Group B. The relationship between these two center-of-pressure (COP) measures and the dogs’ fractional lifespan was examined in both groups and the role of pain and proprioceptive deficits was evaluated in Group B. All measures except for frequency revolve showed good to excellent reliability. Weight, height and length were correlated with most of the measures. Fractional lifespan impacted postural control in Group B but not Group A. Joint pain and its interaction with proprioceptive deficits influence postural sway especially in the acceleration in the craniocaudal direction, while fractional lifespan was most important in the overall COP displacement. In conclusion, our study found that pressure sensitive walkway systems are a reliable tool to evaluate postural sway in dogs; and that postural sway is affected by morphometric parameters and increases with age and joint pain.}, number={7}, journal={PLOS ONE}, publisher={Public Library of Science (PLoS)}, author={Mondino, Alejandra and Wagner, Grant and Russell, Katharine and Lobaton, Edgar and Griffith, Emily and Gruen, Margaret and Lascelles, B. Duncan X. and Olby, Natasha Jane}, editor={Evans, RichardEditor}, year={2022}, month={Jul} }
 @article{griffith_sharp_bridges_craig_hanford_stevens_2022, title={The academic collaborative statistician: Research, training and evaluation}, volume={11}, ISSN={["2049-1573"]}, DOI={10.1002/sta4.483}, abstractNote={Abstract}, number={1}, journal={STAT}, author={Griffith, Emily H. H. and Sharp, Julia L. L. and Bridges, William C. C. and Craig, Bruce A. A. and Hanford, Kathryn J. J. and Stevens, John R. R.}, year={2022}, month={Dec} }
 @article{harlow_griesgraber_seman_shuping_sommer_griffith_hileman_nestor_2022, title={The impact of undernutrition on KNDy (kisspeptin/neurokinin B/dynorphin) neurons in female lambs}, volume={34}, ISSN={["1365-2826"]}, url={https://doi.org/10.1111/jne.13135}, DOI={10.1111/jne.13135}, abstractNote={Abstract}, number={6}, journal={JOURNAL OF NEUROENDOCRINOLOGY}, publisher={Wiley}, author={Harlow, KaLynn and Griesgraber, Max J. and Seman, Andrew D. and Shuping, Sydney L. and Sommer, Jeffrey R. and Griffith, Emily H. and Hileman, Stanley M. and Nestor, Casey C.}, year={2022}, month={May} }
 @article{li_yamamoto_belikoff_berger_griffith_scott_2021, title={A conditional female lethal system for genetic suppression of the global fruit crop pest <scp><i>Drosophila suzukii}, volume={77}, ISSN={1526-498X 1526-4998}, url={http://dx.doi.org/10.1002/ps.6530}, DOI={10.1002/ps.6530}, abstractNote={Abstract}, number={11}, journal={Pest Management Science}, publisher={Wiley}, author={Li, Fang and Yamamoto, Akihiko and Belikoff, Esther J and Berger, Amy and Griffith, Emily H and Scott, Maxwell J}, year={2021}, month={Jul}, pages={4915–4922} }
 @article{burgener_hyland_griffith_mitasova_zanno_gates_2021, title={An extreme climate gradient-induced ecological regionalization in the Upper Cretaceous Western Interior Basin of North America}, volume={133}, ISSN={["1943-2674"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-85111073513&partnerID=MN8TOARS}, DOI={10.1130/B35904.1}, abstractNote={Abstract}, number={9-10}, journal={GEOLOGICAL SOCIETY OF AMERICA BULLETIN}, author={Burgener, Landon and Hyland, Ethan and Griffith, Emily and Mitasova, Helena and Zanno, Lindsay E. and Gates, Terry A.}, year={2021}, pages={2125–2136} }
 @article{dorman_kudenov_lytle_griffith_huseth_2021, title={Computer vision for detecting field‐evolved lepidopteran resistance to
            <i>Bt
            maize}, volume={77}, ISSN={1526-498X 1526-4998}, url={http://dx.doi.org/10.1002/ps.6566}, DOI={10.1002/ps.6566}, abstractNote={Abstract}, number={11}, journal={Pest Management Science}, publisher={Wiley}, author={Dorman, Seth J and Kudenov, Michael W and Lytle, Amanda J and Griffith, Emily H and Huseth, Anders S}, year={2021}, month={Aug}, pages={5236–5245} }
 @article{perdew_emke_johnson_dixit_song_griffith_watson_gruen_2021, title={Evaluation of Pexion(R) (imepitoin) for treatment of storm anxiety in dogs: A randomised, double-blind, placebo-controlled trial}, volume={188}, ISSN={["2042-7670"]}, url={https://doi.org/10.1002/vetr.18}, DOI={10.1002/vetr.18}, abstractNote={Abstract}, number={9}, journal={VETERINARY RECORD}, publisher={Wiley}, author={Perdew, Irina and Emke, Carrie and Johnson, Brianna and Dixit, Vaidehi and Song, Yukun and Griffith, Emily H. and Watson, Philip and Gruen, Margaret E.}, year={2021}, month={May} }
 @article{lynch_ruterbories_griffith_hanel_stablein_brooks_2021, title={Evaluation of point-of-care coagulation tests as alternatives to anti-Xa activity for monitoring the anticoagulant effects of rivaroxaban in healthy dogs}, volume={31}, ISSN={["1476-4431"]}, url={https://doi.org/10.1111/vec.13011}, DOI={10.1111/vec.13011}, abstractNote={Abstract}, number={1}, journal={JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE}, author={Lynch, Alex M. and Ruterbories, Laura K. and Griffith, Emily H. and Hanel, Rita M. and Stablein, Alyssa P. and Brooks, Marjory B.}, year={2021}, month={Jan}, pages={18–24} }
 @article{kielb basile_lynch_ruterbories_castaneda_griffith_ueda_2021, title={Influence of long-stay jugular catheters on hemostatic variables in healthy dogs}, volume={7}, ISSN={["1476-4431"]}, url={https://doi.org/10.1111/vec.13085}, DOI={10.1111/vec.13085}, abstractNote={Abstract}, journal={JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE}, author={Kielb Basile, Jessica L. and Lynch, Alex M. and Ruterbories, Laura and Castaneda, Kady and Griffith, Emily and Ueda, Yu}, year={2021}, month={Jul} }
 @article{pankratz_korman_emke_johnson_griffith_gruen_2021, title={Randomized, Placebo-Controlled Prospective Clinical Trial Evaluating the Efficacy of the Assisi Anti-anxiety Device (Calmer Canine) for the Treatment of Canine Separation Anxiety}, volume={8}, ISSN={["2297-1769"]}, DOI={10.3389/fvets.2021.775092}, abstractNote={Introduction: Separation anxiety (SA) is among the most common canine behavior disorders and affects quality-of-life for dogs and their owners. Dogs with SA show signs of anxiety during absence or perceived absence of their owners. While psychoactive medications are often helpful for treating SA, dog and human factors may limit their utility. This study explored the efficacy of a pulsed electromagnetic field (PEMF) device for treatment of canine SA.}, journal={FRONTIERS IN VETERINARY SCIENCE}, author={Pankratz, Katherine and Korman, Judy and Emke, Carrie and Johnson, Brianna and Griffith, Emily H. and Gruen, Margaret E.}, year={2021}, month={Dec} }
 @article{sharp_griffith_higgs_2021, title={Setting the Stage: Statistical Collaboration Videos for Training the Next Generation of Applied Statisticians}, ISSN={["2693-9169"]}, DOI={10.1080/26939169.2021.1934202}, abstractNote={Abstract Collaborative work is inherent to being a statistician or data scientist, yet opportunities for training and exposure to real-world scenarios are often only a small part of a student’s academic program. Resources to facilitate effective and meaningful instruction in communication and collaboration are limited, particularly when compared to the abundant resources available to support traditional statistical training in theory and methods. Our work helps fill the need for resources by providing ten modern, freely-available videos of mock collaborative interactions, with supporting discussion questions, scripts, and other resources. Videos are particularly helpful for teaching communication dynamics. These videos are set in the context of academic research discussions, though the scenarios are broad enough to facilitate discussions for other collaborative contexts as well. The videos and associated resources are designed to be incorporated into existing curricula related to collaboration. The materials have been piloted with positive feedback from students and instructors. Supplemental files for this article are available online.}, journal={JOURNAL OF STATISTICS AND DATA SCIENCE EDUCATION}, author={Sharp, Julia L. and Griffith, Emily H. and Higgs, Megan D.}, year={2021}, month={Jul} }
 @article{howe_cone_piedrahita_collins_fordham_griffith_spang_fisher_2021, title={Sex-specific biomechanics and morphology of the anterior cruciate ligament during skeletal growth in a porcine model}, volume={11}, ISSN={["1554-527X"]}, DOI={10.1002/jor.25207}, abstractNote={Abstract}, journal={JOURNAL OF ORTHOPAEDIC RESEARCH}, author={Howe, Danielle and Cone, Stephanie G. and Piedrahita, Jorge A. and Collins, Bruce and Fordham, Lynn A. and Griffith, Emily H. and Spang, Jeffrey T. and Fisher, Matthew B.}, year={2021}, month={Nov} }
 @article{lynch_ruterbories_griffith_hanel_stablein_brooks_2021, title={The influence of feeding and gastroprotectant medications on the Factor Xa inhibitory activity of orally administered rivaroxaban in normal dogs}, volume={31}, ISSN={["1476-4431"]}, url={https://doi.org/10.1111/vec.13019}, DOI={10.1111/vec.13019}, abstractNote={Abstract}, number={1}, journal={JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE}, author={Lynch, Alex M. and Ruterbories, Laura K. and Griffith, Emily and Hanel, Rita M. and Stablein, Alyssa P. and Brooks, Marjory B.}, year={2021}, month={Jan}, pages={59–65} }
 @article{lombardo_buckel_hain_griffith_white_2020, title={Evidence for temperature-dependent shifts in spawning times of anadromous alewife (Alosa pseudoharengus) and blueback herring (Alosa aestivalis)}, volume={77}, ISSN={["1205-7533"]}, DOI={10.1139/cjfas-2019-0140}, abstractNote={ We analyzed four decades of presence–absence data from a fishery-independent survey to characterize the long-term phenology of river herring (alewife, Alosa pseudoharengus; and blueback herring, Alosa aestivalis) spawning migrations in their southern distribution. We used logistic generalized additive models to characterize the average ingress, peak, and egress timing of spawning. In the 2010s, alewife arrived to spawning habitat 16 days earlier and egressed 27 days earlier (peak 12 days earlier) relative to the 1970s. Blueback herring arrived 5 days earlier and egressed 23 days earlier (peak 13 days earlier) in the 2010s relative to the 1980s. The changes in ingress and egress timing have shortened the occurrence in spawning systems by 11 days for alewife over four decades and 18 days for blueback herring over three decades. We found that the rate of vernal warming was faster during 2001–2016 relative to 1973–1988 and is the most parsimonious explanation for changes in spawning phenology. The influence of a shortened spawning season on river herring population dynamics warrants further investigation. }, number={4}, journal={CANADIAN JOURNAL OF FISHERIES AND AQUATIC SCIENCES}, author={Lombardo, Steven M. and Buckel, Jeffrey A. and Hain, Ernie F. and Griffith, Emily H. and White, Holly}, year={2020}, month={Apr}, pages={741–751} }
 @article{drake_peterson_griffith_olfenbuttel_deperno_moorman_2020, title={How Urban Identity, Affect, and Knowledge Predict Perceptions About Coyotes and Their Management}, volume={33}, ISSN={["1753-0377"]}, DOI={10.1080/08927936.2020.1694302}, abstractNote={ABSTRACT Globally, the number of humans and wildlife species sharing urban spaces continues to grow. As these populations grow, so too does the frequency of human–wildlife interactions in urban areas. Carnivores in particular pose urban wildlife conservation challenges owing to the strong emotions they elicit and the potential threats they can present to humans. These challenges can be better addressed with an understanding of the different factors that influence public perceptions of carnivores and their management. We conducted mail surveys in four cities in North Carolina (n =721) to explore how (a) city of residence, (b) affectual connections to coyotes (Canis latrans), and (c) biological knowledge predicted perceptions of the danger posed by coyotes, the support for wild coyotes living nearby, and the support for lethal coyote removal methods. Our results provide the first assessment of how public perceptions of carnivores and their management vary between cities of different types. Residents from a tourism-driven city were more supportive of coyotes than residents from an industrial city and less concerned about risk than residents from a commercial city. We found affectual connection to coyotes and city of residence were consistent predictors of coyote perceptions. Respondents’ knowledge of coyote biology was not a significant predictor of any perceptions of coyotes despite the relatively high statistical power of the tests. Affectual connection to coyotes had the greatest effect on predicting coyote perceptions, suggesting efforts to promote positive emotional connections to wildlife may be a better way to increase acceptance of carnivores in urban areas than focusing on biological knowledge.}, number={1}, journal={ANTHROZOOS}, author={Drake, Michael D. and Peterson, M. Nils and Griffith, Emily H. and Olfenbuttel, Colleen and DePerno, Cristopher S. and Moorman, Christopher E.}, year={2020}, month={Jan}, pages={5–19} }
 @article{mellinger_griffith_bereman_2020, title={Peptide variability and signatures associated with disease progression in CSF collected longitudinally from ALS patients}, volume={412}, ISSN={["1618-2650"]}, DOI={10.1007/s00216-020-02765-8}, abstractNote={We employ shotgun proteomics and data-independent acquisition (DIA) mass spectrometry to analyze cerebrospinal fluid longitudinally collected from 14 amyotrophic lateral sclerosis (ALS) patients (8 males and 6 females). We perform three main analyses of these data: (1) examine the intra- and inter-patient protein variability in CSF; (2) explore the association of inflammation with rate of disease progression; and (3) develop a mixed-effects model to best explain the decrease in ALS-Functional Rating Scale (ALS-FRS) score. Overall, the CSF protein abundances are tightly regulated with the intra-individual variability contributing just 4% to the overall variance. In four patients, a moderately significant correlation (p < 0.1) was observed between inflammation and rate of disease progression. Using a least absolute shrinkage and selection operator (LASSO) variable selection, we selected 55 viable peptides for mathematical modeling via a linear mixed-effects regression. We then employed forward selection to generate a final model by minimizing Akaike's information criterion (AIC). The final model utilized changes in abundance from 28 peptides as fixed effects to model progression of the disease in these patients. These peptides were from proteins involved in stress response and innate immunity. Graphical abstract.}, number={22}, journal={ANALYTICAL AND BIOANALYTICAL CHEMISTRY}, author={Mellinger, Allyson L. and Griffith, Emily H. and Bereman, Michael S.}, year={2020}, month={Sep}, pages={5465–5475} }
 @article{durodoye_gumpertz_wilson_griffith_ahmad_2020, title={Tenure and Promotion Outcomes at Four Large Land Grant Universities: Examining the Role of Gender, Race, and Academic Discipline}, volume={61}, ISSN={["1573-188X"]}, DOI={10.1007/s11162-019-09573-9}, number={5}, journal={RESEARCH IN HIGHER EDUCATION}, author={Durodoye, Raifu, Jr. and Gumpertz, Marcia and Wilson, Alyson and Griffith, Emily and Ahmad, Seher}, year={2020}, month={Aug}, pages={628–651} }
 @article{krasner_hancock-ronemus_christian_griffith_lewbart_law_2019, title={Histological evaluation of five suture materials in the telson ligament of the American horseshoe crab (Limulus polyphemus)}, volume={7}, ISSN={["2167-8359"]}, DOI={10.7717/peerj.7061}, abstractNote={An ideal suture material supports healing, minimizes inflammation, and decreases the likelihood of secondary infection. While there are published recommendations for suture materials in some invertebrates, there are no published recommendations forLimulus polyphemusor any chelicerate. This study evaluates the histological reaction of horseshoe crabs to five commonly used suture materials: monofilament nylon, silk, poliglecaprone, polydioxanone, and polyglycolic acid. None of the materials were superior with regards to holding nor was there any dehiscence. Nylon evoked the least amount of tissue reaction. This work also provides a histopathological description of the soft membrane at the hinge area between the opisthosoma and telson (telson ligament) and comments on euthanasia with intracardiac eugenol.}, journal={PEERJ}, author={Krasner, Ami E. and Hancock-Ronemus, Amy and Christian, Larry S. and Griffith, Emily H. and Lewbart, Gregory A. and Law, Jerry M.}, year={2019}, month={Aug} }
 @article{drake_peterson_griffith_olfenbuttel_moorman_deperno_2019, title={Hunting interacts with socio-demographic predictors of human perceptions of urban coyotes}, volume={43}, ISSN={["1938-5463"]}, DOI={10.1002/wsb.993}, abstractNote={ABSTRACT}, number={3}, journal={WILDLIFE SOCIETY BULLETIN}, author={Drake, Michael D. and Peterson, M. Nils and Griffith, Emily H. and Olfenbuttel, Colleen and Moorman, Christopher E. and Deperno, Christopher S.}, year={2019}, month={Sep}, pages={447–454} }
 @article{gingold_killos_griffith_posner_2019, title={Measurement of peripheral muscle oxygen saturation in conscious healthy horses using a near-infrared spectroscopy device}, volume={46}, ISSN={["1467-2995"]}, DOI={10.1016/j.vaa.2019.07.001}, abstractNote={Objective Maintaining adequate muscle tissue oxygenation is of paramount importance during equine general anesthesia. The objectives of this study were to assess the feasibility, reliability and repeatability of near-infrared spectroscopy (NIRS) muscle oximetry using the Inspectra m650 in conscious healthy adult horses. Study design Prospective, observational study. Animals A group of 30 healthy client-owned adult horses admitted to the equine hospital between July 2017 and July 2018. Methods The probe of an Inspectra m650 NIRS tissue oximeter was placed on the hairless surface of five muscle sites (omotransversarius, triceps long head, extensor carpi ulnaris, vastus lateralis and lateral digital extensor) on the left side of the body of each standing, unsedated horse. Each site had muscle oxygenation (StO2) recordings measured in triplicate and statistical modeling used to assess the reading reliability and repeatability within and between muscle sites. Results The readings acquired at the vastus lateralis and extensor carpi ulnaris muscle sites had highly repeatable values [mean (90% confidence interval): StO2, 95% (93.8%, 96.5%) and 93% (91.6%, 93.9%), respectively; intraclass correlation coefficients, 0.92 and 0.80, respectively]. These two sites also had high reliability (represented by the percentage of successful readings; 70% and 86%, respectively). Conclusions and clinical relevance The use of NIRS muscle oxygenation technology is a clinically feasible means to assess tissue oxygenation in horses. The vastus lateralis and extensor carpi ulnaris muscle sites provided the most reliable and repeatable readings when using the Inspectra m650 machine in horses.}, number={6}, journal={VETERINARY ANAESTHESIA AND ANALGESIA}, author={Gingold, Benjamin M. C. and Killos, Maria B. and Griffith, Emily and Posner, Lysa}, year={2019}, month={Nov}, pages={789–795} }
 @article{zidan_sims_fenn_williams_griffith_early_mariani_munana_guevar_olby_et al._2018, title={A randomized, blinded, prospective clinical trial of postoperative rehabilitation in dogs after surgical decompression of acute thoracolumbar intervertebral disc herniation}, volume={32}, ISSN={0891-6640}, url={http://dx.doi.org/10.1111/jvim.15086}, DOI={10.1111/jvim.15086}, abstractNote={BackgroundExperimental evidence shows benefit of rehabilitation after spinal cord injury (SCI) but there are limited objective data on the effect of rehabilitation on recovery of dogs after surgery for acute thoracolumbar intervertebral disc herniations (TL‐IVDH).}, number={3}, journal={Journal of Veterinary Internal Medicine}, publisher={Wiley}, author={Zidan, Natalia and Sims, Cory and Fenn, Joe and Williams, Kim and Griffith, Emily and Early, Peter J. and Mariani, Chris L. and Munana, Karen and Guevar, Julien and Olby, Natasha J. and et al.}, year={2018}, month={Apr}, pages={1133–1144} }
 @article{risselada_winter_lewis_griffith_pozzi_2018, title={Comparison of three imaging modalities used to evaluate bone healing after tibial tuberosity advancement in cranial cruciate ligament-deficient dogs and comparison of the effect of a gelatinous matrix and a demineralized bone matrix mix on bone healing - a pilot study}, volume={14}, journal={BMC Veterinary Research}, author={Risselada, M. and Winter, M. D. and Lewis, D. D. and Griffith, E. and Pozzi, A.}, year={2018} }
 @article{kennedy_thomson_griffith_fogle_lascelles_meeker_sherman_gruen_2018, title={Enrichment Preferences of FIV-Infected and Uninfected Laboratory-Housed Cats}, volume={10}, ISSN={1999-4915}, url={http://dx.doi.org/10.3390/v10070353}, DOI={10.3390/v10070353}, abstractNote={Environmental enrichment is critical for alleviating stress in laboratory felines. However, there is a paucity of information about suitable enrichment for cats. This study aimed to determine preferred enrichment options of individually-housed, castrated male domestic short hair cats (Felis catus) used in a longitudinal study of the effects of chronic feline immunodeficiency virus (FIV) infection, and to determine if the FIV status of the cats affected enrichment preferences. Preference testing was performed with two types of grooming brushes, three different interactive play options, including a laser, ball, and petting interaction with a familiar investigator, and two types of toenail conditioning objects. We found that cats elected to be brushed, preferred social interaction and play with the laser to the ball, and preferred to scratch on an inclined-box toenail conditioning object compared to a horizontal, circular toenail conditioning object. There were individual preferences for enrichment opportunities. There were no differences in preferences between FIV-infected and sham-infected cats. These enrichment preferences may be used to advise laboratory animal facilities and researchers about how to best accommodate the behavioral needs of laboratory cats.}, number={7}, journal={Viruses}, publisher={MDPI AG}, author={Kennedy, Claudia and Thomson, Andrea and Griffith, Emily and Fogle, Jonathan and Lascelles, B. and Meeker, Rick and Sherman, Barbara and Gruen, Margaret}, year={2018}, month={Jul}, pages={353} }
 @article{risselada_griffith_kapler_mcdonald-lynch_2018, title={Evaluation of various gastrojejunostomy tube constructs for enteral support of small animal patients}, volume={252}, ISSN={["1943-569X"]}, DOI={10.2460/javma.252.10.1239}, abstractNote={Abstract}, number={10}, journal={JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION}, author={Risselada, Marije and Griffith, Emily and Kapler, Meredith and McDonald-Lynch, Mischa}, year={2018}, month={May}, pages={1239–1246} }
 @article{curto_griffith_posner_walsh_balko_gilger_2018, title={Factors associated with postoperative complications in healthy horses after general anesthesia for ophthalmic versus non-ophthalmic procedures: 556 cases (2012–2014)}, volume={252}, ISSN={["1943-569X"]}, DOI={10.2460/javma.252.9.1113}, abstractNote={Abstract}, number={9}, journal={Journal of the American Veterinary Medical Association}, publisher={In press}, author={Curto, E.M. and Griffith, E.H. and Posner, L.P. and Walsh, K.T. and Balko, J.A. and Gilger, B.C.}, year={2018}, month={May}, pages={1113–1119} }
 @article{sylvester_griffith_jacob_foster_2018, title={Factors associated with strongyle infection in goats at the individual and farm level}, volume={253}, ISSN={["1943-569X"]}, url={https://doi.org/10.2460/javma.253.7.907}, DOI={10.2460/javma.253.7.907}, abstractNote={Abstract}, number={7}, journal={JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION}, author={Sylvester, Hannah J. and Griffith, Emily H. and Jacob, Megan E. and Foster, Derek M.}, year={2018}, month={Oct}, pages={907–917} }
 @article{balko_gatson_cohen_griffith_harms_bailey_2018, title={INHALANT ANESTHETIC RECOVERY FOLLOWING INTRAMUSCULAR EPINEPHRINE IN THE LOGGERHEAD SEA TURTLE (CARETTA CARETTA)}, volume={49}, ISSN={["1937-2825"]}, url={https://doi.org/10.1638/2017-0182.1}, DOI={10.1638/2017-0182.1}, abstractNote={Abstract Prolonged anesthetic recovery time is a common complication of chelonian inhalant anesthesia and may be exacerbated by right-to-left intracardiac shunting of blood. Epinephrine may decrease intracardiac shunting, which may shorten anesthetic recovery time. The study objective was to assess inhalant anesthetic recovery time following intramuscular epinephrine compared with saline in the loggerhead sea turtle (Caretta caretta). With the use of a prospective, randomized, blinded, crossover design with a 1-wk washout period, six turtles were anesthetized with intravenous (IV) alfaxalone 3 mg/kg, orotracheally intubated, manually ventilated with 3.5% isoflurane inhalant in 100% oxygen for 90 min, and administered either intramuscular (IM) epinephrine 0.1 mg/kg or IM saline 0.1 ml/kg. Isoflurane administration was immediately discontinued and turtles were manually ventilated with room air until extubation. Physiologic variables, sedation scores, end-tidal carbon dioxide (ETCO2) and isoflurane (ETISO) concentrations, time to first movement, and time to extubation were recorded and two-time-point venous blood gas analyses performed. Data were compared with the use of paired t-tests and repeated-measures analyses of variance (ANOVA) (P < 0.05). No morbidity, mortality, or adverse events occurred. ETCO2 and ETISO did not significantly change over time during the isoflurane delivery period (P = 0.990). Mean time to first movement was significantly faster following epinephrine (69.24 ± 12.28 min) compared with saline (87.71 ± 27.05 min, P = 0.047). Although differences were not statistically significant (P = 0.133), time to extubation was at least 30 min faster (31–123 min) in 4/6 turtles following epinephrine compared with saline. Intramuscular epinephrine significantly reduces time to first movement during isoflurane anesthetic recovery in loggerhead sea turtles.}, number={3}, journal={JOURNAL OF ZOO AND WILDLIFE MEDICINE}, author={Balko, Julie A. and Gatson, Bonnie J. and Cohen, Eli B. and Griffith, Emily H. and Harms, Craig A. and Bailey, Kate M.}, year={2018}, month={Sep}, pages={680–688} }
 @article{sparks_gorney_williams_griffith_cerda-gonzalez_lascelles_olby_2018, title={Investigation of sensory thresholds in Cavalier King Charles Spaniels with and without Chiari-like malformations and syringomyelia}, volume={32}, ISSN={0891-6640}, url={http://dx.doi.org/10.1111/jvim.15297}, DOI={10.1111/jvim.15297}, abstractNote={BackgroundCavalier King Charles Spaniels (CKCS) suffer pain associated with Chiari‐like malformation and syringomyelia (CMSM). People suffer from a similar condition and describe numerous sensory abnormalities. Sensory changes have not been quantified in affected CKCS.}, number={6}, journal={Journal of Veterinary Internal Medicine}, publisher={Wiley}, author={Sparks, Courtney R. and Gorney, Angela and Williams, Kim and Griffith, Emily H. and Cerda-Gonzalez, Sofia and Lascelles, B. Duncan X. and Olby, Natasha J.}, year={2018}, month={Oct}, pages={2021–2028} }
 @article{zidan_fenn_griffith_early_mariani_muñana_guevar_olby_2018, title={The Effect of Electromagnetic Fields on Post-Operative Pain and Locomotor Recovery in Dogs with Acute, Severe Thoracolumbar Intervertebral Disc Extrusion: A Randomized Placebo-Controlled, Prospective Clinical Trial}, volume={35}, ISSN={0897-7151 1557-9042}, url={http://dx.doi.org/10.1089/neu.2017.5485}, DOI={10.1089/neu.2017.5485}, abstractNote={Spinal cord injury (SCI) attributed to acute intervertebral disc extrusions (IVDEs) is common in dogs and is treated by surgical decompression. Dogs with sensorimotor complete injuries have an incomplete recovery. Pulsed electromagnetic fields (PEMFs) reduce post-operative pain through anti-inflammatory effects and there is growing evidence for neuroprotective effects. This randomized, controlled clinical trial evaluated the effect of PEMF on post-operative pain and neurological recovery in dogs with surgically treated sensorimotor complete SCI attributed to acute IVDE. Sixteen dogs with surgically treated complete thoracolumbar SCI were randomized to receive PEMF (15 min every 2 h for 2 weeks then twice-daily for 4 weeks) or placebo starting immediately after diagnosis. The primary outcome was gait score at 2 weeks. Secondary measures of gait, pain perception, and proprioceptive function were evaluated at 2 and 6 weeks. Plasma glial fibrillary acidic protein (GFAP) concentration was measured as an SCI biomarker. Post-operative pain was quantified by measuring mechanical sensory thresholds (MSTs) at control and surgical sites. There was no significant difference in demographics or GFAP concentration between the two groups at trial entry. There was no difference in primary outcome or in secondary measures of gait, but proprioceptive placing was significantly better at 6 weeks and GFAP concentrations were significantly lower at 2 weeks in the PEMF group. MSTs were significantly higher in the PEMF-treated group. We conclude that PEMF reduced incision-associated pain in dogs post-surgery for IVDE and may reduce extent of SCI and enhance proprioceptive placing. Larger clinical trials are warranted.}, number={15}, journal={Journal of Neurotrauma}, publisher={Mary Ann Liebert Inc}, author={Zidan, Natalia and Fenn, Joe and Griffith, Emily and Early, Peter J. and Mariani, Chris L. and Muñana, Karen R. and Guevar, Julien and Olby, Natasha J.}, year={2018}, month={Aug}, pages={1726–1736} }
 @article{pankratz_ferris_griffith_sherman_2018, title={Use of single-dose oral gabapentin to attenuate fear responses in cage-trap confined community cats: a double-blind, placebo-controlled field trial}, volume={20}, ISSN={["1532-2750"]}, DOI={10.1177/1098612x17719399}, abstractNote={Objectives This double-blind, placebo-controlled study evaluated the safety and efficacy of single-dose oral gabapentin administered for the attenuation of fear responses in cage-trap confined community cats. }, number={6}, journal={JOURNAL OF FELINE MEDICINE AND SURGERY}, author={Pankratz, Katherine E. and Ferris, Kelli K. and Griffith, Emily H. and Sherman, Barbara L.}, year={2018}, month={Jun}, pages={535–543} }
 @article{cone_martin_marcellin-little_harrysson_griffith_2017, title={Accuracy and repeatability of long-bone replicas of small animals fabricated by use of low-end and high-end commercial three-dimensional printers}, volume={78}, DOI={10.2460/ajvr.78.8.900}, abstractNote={Abstract}, number={8}, journal={American Journal of Veterinary Research}, author={Cone, J. A. and Martin, T. M. and Marcellin-Little, D. J. and Harrysson, O. L. A. and Griffith, E. H.}, year={2017}, pages={900–905} }
 @article{mutz_boudreaux_royal_merchant_pucheu-haston_griffith_gieger_2017, title={Cytologic comparison of the percentage of mast cells in lymph node aspirate samples from clinically normal dogs versus dogs with allergic dermatologic disease and dogs with cutaneous mast cell tumors}, volume={251}, ISSN={["1943-569X"]}, DOI={10.2460/javma.251.4.421}, abstractNote={Abstract}, number={4}, journal={JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION}, author={Mutz, Melanie L. and Boudreaux, Bonnie B. and Royal, Angela and Merchant, Sandra and Pucheu-Haston, Cherie and Griffith, Emily H. and Gieger, Tracy L.}, year={2017}, month={Aug}, pages={421–428} }
 @article{parr_griffith_grossman_2017, title={Drivers of promiscuous soybean associated rhizobia diversity in un-inoculated soil in Malawi}, volume={71}, ISSN={["1878-7665"]}, DOI={10.1007/s13199-016-0420-0}, number={2}, journal={SYMBIOSIS}, author={Parr, Mary and Griffith, Emily and Grossman, Julie}, year={2017}, month={Feb}, pages={129–141} }
 @article{swift_foster_rogers_sylvester_griffith_jacob_2017, title={Efficacy of an Escherichia coli O157:H7 SRP Vaccine in Orally Challenged Goats and Strain Persistence Over Time}, volume={14}, ISSN={["1556-7125"]}, url={https://doi.org/10.1089/fpd.2016.2213}, DOI={10.1089/fpd.2016.2213}, abstractNote={Small ruminants have been implicated in outbreaks of Escherichia coli O157:H7 at livestock exhibitions throughout the United States. Additionally, goat meat or milk may serve as a reservoir for foodborne transmission of the organism. These associations highlight the public health importance of an effective strategy to reduce E. coli O157:H7 shedding in goats. We examined the efficacy of the SRP® vaccine in goats orally challenged with E. coli O157:H7. Mixed-breed goats (n = 14) were randomly allocated into vaccinated and unvaccinated treatments (n = 7 per treatment). Goats were housed with a vaccinated and unvaccinated animal in each pen. Feces were collected for 3 weeks, then at necropsy, gastrointestinal contents were collected to determine the concentration of E. coli O157:H7. Three isolates per positive sample were saved and evaluated by pulsed-field gel electrophoresis (PFGE) to assess strain persistence over time. The mean concentration of E. coli O157:H7 in the feces of goats was numerically reduced in the vaccinated treatment; however, it was not statistically significant. In addition, the total number of days goats were fecal positive for E. coli O157:H7 were not different between vaccinated and unvaccinated treatments. Pulsotypes of isolates revealed that goats initially shed two of the four challenge strains of E. coli O157:H7, after which there was a distinct shift to two different strains. Further work is needed to evaluate cost-effective intervention strategies that reliably reduce E. coli O157:H7 shedding in goats, particularly those that may reduce the risk of transmission at public events, including petting zoos and fairs.}, number={3}, journal={FOODBORNE PATHOGENS AND DISEASE}, author={Swift, Jacob M. and Foster, Derek M. and Rogers, Anna T. and Sylvester, Hannah J. and Griffith, Emily H. and Jacob, Megan E.}, year={2017}, month={Mar}, pages={160–166} }
 @article{nordberg_zhang_griffith_frank_starly_loboa_2017, title={Electrical Cell-Substrate Impedance Spectroscopy Can Monitor Age-Grouped Human Adipose Stem Cell Variability During Osteogenic Differentiation}, volume={6}, ISSN={["2157-6580"]}, DOI={10.5966/sctm.2015-0404}, abstractNote={Abstract}, number={2}, journal={STEM CELLS TRANSLATIONAL MEDICINE}, author={Nordberg, Rachel C. and Zhang, Jianlei and Griffith, Emily H. and Frank, Matthew W. and Starly, Binil and Loboa, Elizabeth G.}, year={2017}, month={Feb}, pages={502–511} }
 @article{gruen_messenger_thomson_griffith_aldrich_vaden_lascelles_2017, title={Evaluation of serum cytokines in cats with and without degenerative joint disease and associated pain}, volume={183}, ISSN={0165-2427}, url={http://dx.doi.org/10.1016/J.VETIMM.2016.12.007}, DOI={10.1016/J.VETIMM.2016.12.007}, abstractNote={Degenerative joint disease is common in cats, with signs of pain frequently found on orthopedic examination and radiographs often showing evidence of disease. However, understanding of the pathophysiology of degenerative joint disease and associated pain remains limited. Several cytokines have been identified as having a role in pain in humans, but this has not been investigated in cats. The present study was performed to use a multiplex platform to evaluate the concentration of 19 cytokines and chemokines in serum samples obtained from cats with and without degenerative joint disease and associated pain. Samples from a total of 186 cats were analyzed, with cats representing a range of severity on radiographic and orthopedic evaluations and categorized by degenerative joint disease scores and pain scores. Results showed that cats with higher radiographic degenerative joint disease scores have higher serum concentrations of IL-4 and IL-8, while cats with higher orthopedic exam pain scores have higher concentrations of IL-8, IL-2, and TNF-α; increased concentration of IL-8 in degenerative joint disease and pain may be confounded by the association with age. Discriminant analysis was unable to identify one or more cytokines that distinguish between groups of cats classified based on degenerative joint disease score category or pain score category. Finally, cluster analysis driven by analyte concentrations shows separation of groups of cats, but features defining the groups remain unknown. Further studies are warranted to investigate any changes in cytokine concentrations in response to analgesic therapies, and further evaluate the elevations in cytokine concentrations found here, particularly focused on studies of local cytokines present in synovial fluid.}, journal={Veterinary Immunology and Immunopathology}, publisher={Elsevier BV}, author={Gruen, Margaret E. and Messenger, Kristen M. and Thomson, Andrea E. and Griffith, Emily H. and Aldrich, Lauren A. and Vaden, Shelly and Lascelles, B.Duncan X.}, year={2017}, month={Jan}, pages={49–59} }
 @article{nettifee_munana_griffith_2017, title={Evaluation of the Impacts of Epilepsy in Dogs on Their Caregivers}, volume={53}, ISSN={["1547-3317"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-85019011505&partnerID=MN8TOARS}, DOI={10.5326/jaaha-ms-6537}, abstractNote={ABSTRACT}, number={3}, journal={JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION}, author={Nettifee, Julie A. and Munana, Karen R. and Griffith, Emily H.}, year={2017}, pages={143–149} }
 @article{sper_koh_zhang_simpson_collins_sommer_petters_caballero_platt_piedrahita_2017, title={Generation of a stable transgenic swine model expressing a porcine histone 2b-egfp fusion protein for cell tracking and chromosome dynamics studies}, volume={12}, number={1}, journal={PLoS One}, author={Sper, R. B. and Koh, S. and Zhang, X. and Simpson, S. and Collins, B. and Sommer, J. and Petters, R. M. and Caballero, I. and Platt, J. L. and Piedrahita, J. A.}, year={2017} }
 @article{hilton_taylor_hussain_dandley_griffith_garantziotis_parsons_bonner_bereman_2017, title={Mapping differential cellular protein response of mouse alveolar epithelial cells to multi-walled carbon nanotubes as a function of atomic layer deposition coating}, volume={11}, ISSN={["1743-5404"]}, DOI={10.1080/17435390.2017.1299888}, abstractNote={Abstract Carbon nanotubes (CNTs), a prototypical engineered nanomaterial, have been increasingly manufactured for a variety of novel applications over the past two decades. However, since CNTs possess fiber-like shape and cause pulmonary fibrosis in rodents, there is concern that mass production of CNTs will lead to occupational exposure and associated pulmonary diseases. The aim of this study was to use contemporary proteomics to investigate the mechanisms of cellular response in E10 mouse alveolar epithelial cells in vitro after exposure to multi-walled CNTs (MWCNTs) that were functionalized by atomic layer deposition (ALD). ALD is a method used to generate highly uniform and conformal nanoscale thin-film coatings of metals to enhance novel conductive properties of CNTs. We hypothesized that specific types of metal oxide coatings applied to the surface of MWCNTs by ALD would determine distinct proteomic profiles in mouse alveolar epithelial cells in vitro that could be used to predict oxidative stress and pulmonary inflammation. Uncoated (U)-MWCNTs were functionalized by ALD with zinc oxide (ZnO) to yield Z-MWCNTs or aluminum oxide (Al2O3) to yield A-MWCNTs. Significant differential protein expression was found in the following critical pathways: mTOR/eIF4/p70S6K signaling and Nrf-2 mediated oxidative stress response increased following exposure to Z-MWCNTs, interleukin-1 signaling increased following U-MWCNT exposure, and inhibition of angiogenesis by thrombospondin-1, oxidative phosphorylation, and mitochondrial dysfunction increased following A-MWCNT exposure. This study demonstrates that specific types of metal oxide thin film coatings applied by ALD produce distinct cellular and biochemical responses related to lung inflammation and fibrosis compared to uncoated MWCNT exposure in vitro.}, number={3}, journal={NANOTOXICOLOGY}, author={Hilton, Gina M. and Taylor, Alexia J. and Hussain, Salik and Dandley, Erinn C. and Griffith, Emily H. and Garantziotis, Stavros and Parsons, Gregory N. and Bonner, James C. and Bereman, Michael S.}, year={2017}, month={Apr}, pages={313–326} }
 @article{williams_long_durrant_mckeon_shive_griffith_messenger_fish_2017, title={Oral transmucosal detomidine gel in New Zealand white rabbits (Oryctolagus cuniculus)}, volume={56}, number={4}, journal={Journal of the American Association for Laboratory Animal Science}, author={Williams, M. D. and Long, C. T. and Durrant, J. R. and McKeon, G. P. and Shive, H. R. and Griffith, E. H. and Messenger, K. M. and Fish, R. E.}, year={2017}, pages={436–442} }
 @article{risselada_linder_griffith_roberts_davidson_zamboni_messenger_2017, title={Pharmacokinetics and toxicity of subcutaneous administration of carboplatin in poloxamer 407 in a rodent model pilot study}, volume={12}, number={10}, journal={PLoS One}, author={Risselada, M. and Linder, K. E. and Griffith, E. and Roberts, B. V. and Davidson, G. and Zamboni, W. C. and Messenger, K. M.}, year={2017} }
 @article{nolan_arkans_lavine_defrancesco_myers_griffith_posner_keene_tou_gieger_et al._2017, title={Pilot study to determine the feasibility of radiation therapy for dogs with right atrial masses and hemorrhagic pericardial effusion}, volume={19}, ISSN={1760-2734}, url={http://dx.doi.org/10.1016/j.jvc.2016.12.001}, DOI={10.1016/j.jvc.2016.12.001}, abstractNote={To determine the short-term safety and biologic activity of radiation therapy (RT) for presumptive cardiac hemangiosarcoma in pet dogs.Six dogs with echocardiographic evidence of a right atrial/auricular mass, and hemorrhagic pericardial effusion, were enrolled in a prospective, single-arm clinical trial.A single fraction of 12 Gy was delivered using conformal external beam irradiation. Serum cardiac troponin I and plasma concentrations of vascular endothelial growth factor were quantified before, 4 and 24 h after RT. The frequency of required pericardiocenteses (quantified as the number of pericardiocenteses per week) before RT was compared to that after treatment. Overall survival time was determined.No treatment-related complications were observed. Pericardiocentesis was performed an average of 0.91 times per week before RT, and an average of 0.21 times per week after RT; this difference was statistically significant (p=0.03, as compared using a Wilcoxon signed-rank test of paired data). Pre- and post-treatment plasma vascular endothelial growth factor concentrations were not significantly different at any time point; there was a statistically significant (p=0.04; Friedman's test for non-parametric repeated measures) increase in cardiac troponin concentrations 4 h after irradiation. Median overall survival time was 79 days.In this population of dogs, RT was delivered without complication, and appears to have reduced the frequency of periacardial tamponade that necessitated pericardiocentesis. Serum cardiac troponin levels are altered after RT. RT alone, or in combination with chemotherapy, may provide clinical benefit to dogs with presumptive diagnoses of cardiac hemangiosarcoma.}, number={2}, journal={Journal of Veterinary Cardiology}, publisher={Elsevier BV}, author={Nolan, M.W. and Arkans, M.M. and LaVine, D. and DeFrancesco, Teresa and Myers, J.A. and Griffith, E.H. and Posner, L.P. and Keene, B.W. and Tou, S.P. and Gieger, Tracy and et al.}, year={2017}, month={Apr}, pages={132–143} }
 @article{sparks_cerda-gonzalez_griffith_lascelles_olby_2017, title={Questionnaire-based Analysis of Owner-reported Scratching and Pain Signs in Cavalier King Charles Spaniels Screened for Chiari-like Malformation and Syringomyelia}, volume={32}, ISSN={0891-6640}, url={http://dx.doi.org/10.1111/jvim.14856}, DOI={10.1111/jvim.14856}, abstractNote={BackgroundChiari‐like malformation (CM) and syringomyelia (SM) cause a pain syndrome in Cavalier King Charles spaniels (CKCS). Clinical signs are not consistently apparent on neurologic examination, and owner reporting of signs provides vital clinical history. However, owner questionnaires for this disease are not well developed.}, number={1}, journal={Journal of Veterinary Internal Medicine}, publisher={Wiley}, author={Sparks, C.R. and Cerda-Gonzalez, S. and Griffith, E.H. and Lascelles, B.D.X. and Olby, N.J.}, year={2017}, month={Nov}, pages={331–339} }
 @article{harris_parnell_griffith_saker_2017, title={Retrospective evaluation of the impact of early enteral nutrition on clinical outcomes in dogs with pancreatitis: 34 cases (2010-2013)}, volume={27}, ISSN={["1476-4431"]}, DOI={10.1111/vec.12612}, abstractNote={Abstract}, number={4}, journal={JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE}, author={Harris, Jessica P. and Parnell, Nolie K. and Griffith, Emily H. and Saker, Korinn E.}, year={2017}, pages={425–433} }
 @article{gruen_roe_griffith_sherman_2017, title={The use of trazodone to facilitate calm behavior after elective orthopedic surgery in dogs: Results and lessons learned from a clinical trial}, volume={22}, ISSN={1558-7878}, url={http://dx.doi.org/10.1016/J.JVEB.2017.09.008}, DOI={10.1016/J.JVEB.2017.09.008}, abstractNote={Trazodone hydrochloride is an atypical antidepressant that has entered clinical use for dogs and cats for a variety of indications. These include management of anxiety disorders, facilitation of travel and veterinary examinations, and facilitation of calm behavior in hospitalized and postoperative patients. Despite the increasingly common use of trazodone in dogs, very little literature exists evaluating trazodone's efficacy against a placebo control. The aim of the study reported here was to evaluate trazodone in a randomized placebo-controlled clinical trial for use in facilitating calmness and ease of confinement in postoperative dogs. The study enrolled 29 dogs (14 in the trazodone group and 15 in the placebo group) and followed them during 4 postoperative weeks. Trazodone was well tolerated by dogs in the trazodone group. Although dogs in both groups were rated as improved on some behavioral measures, no difference was found between the trazodone and placebo groups in efficacy, with more than 70% of owners in both groups rating the test article (trazodone or placebo) as moderately or extremely helpful for facilitating both calming and crating of their dog. This observed lack of efficacy, over placebo, may be attributed to one or more of several factors that include features about the trial itself and the trial population, a caregiver or placebo-by-proxy effect, a lack of sensitive outcome measures for assessment, or a lack of true efficacy for the medication. It is concluded that future work will be needed to address these factors, and this report aims to provide not only results but lessons learned from the conduct of the described trial.}, journal={Journal of Veterinary Behavior}, publisher={Elsevier BV}, author={Gruen, Margaret E. and Roe, Simon C. and Griffith, Emily H. and Sherman, Barbara L.}, year={2017}, month={Nov}, pages={41–45} }
 @article{smith_marcellin-little_harrysson_griffith_2017, title={Three-dimensional assessment of curvature, torsion, and canal flare index of the humerus of skeletally mature nonchondrodystrophic dogs}, volume={78}, DOI={10.2460/ajvr.78.10.1140}, abstractNote={Abstract}, number={10}, journal={American Journal of Veterinary Research}, author={Smith, E. J. and Marcellin-Little, D. J. and Harrysson, Ola and Griffith, E. H.}, year={2017}, pages={1140–1149} }
 @article{bullen_evola_griffith_seiler_saker_2017, title={Validation of ultrasonographic muscle thickness measurements as compared to the gold standard of computed tomography in dogs}, volume={5}, journal={PeerJ}, author={Bullen, L. E. and Evola, M. G. and Griffith, E. H. and Seiler, G. S. and Saker, K. E.}, year={2017} }
 @article{gruen_thomson_griffith_paradise_gearing_lascelles_2016, title={A Feline-Specific Anti-Nerve Growth Factor Antibody Improves Mobility in Cats with Degenerative Joint Disease-Associated Pain: A Pilot Proof of Concept Study}, volume={30}, ISSN={0891-6640}, url={http://dx.doi.org/10.1111/jvim.13972}, DOI={10.1111/jvim.13972}, abstractNote={BackgroundNeutralizing antibodies against nerve growth factor (NGF) are analgesic in rodent models, naturally occurring degenerative joint disease (DJD) pain in dogs, and chronic pain in humans.}, number={4}, journal={Journal of Veterinary Internal Medicine}, publisher={Wiley}, author={Gruen, M.E. and Thomson, A.E. and Griffith, E.H. and Paradise, H. and Gearing, D.P. and Lascelles, B.D.X.}, year={2016}, month={Jun}, pages={1138–1148} }
 @article{gruen_messenger_thomson_griffith_paradise_vaden_lascelles_2016, title={A comparison of serum and plasma cytokine values using a multiplexed assay in cats}, volume={182}, ISSN={0165-2427}, url={http://dx.doi.org/10.1016/j.vetimm.2016.10.003}, DOI={10.1016/j.vetimm.2016.10.003}, abstractNote={Degenerative joint disease (DJD) is highly prevalent in cats, and pain contributes to morbidity. In humans, alterations of cytokine concentrations have been associated with joint deterioration and pain. Similar changes have not been investigated in cats. Cytokine concentrations can be measured using multiplex technology with small samples of serum or plasma, however, serum and plasma are not interchangeable for most bioassays. Correlations for cytokine concentrations between serum and plasma have not been evaluated in cats.To evaluate the levels of detection and agreement between serum and plasma samples in cats.Paired serum and plasma samples obtained from 38 cats.Blood was collected into anti-coagulant free and EDTA Vacutainer® tubes, serum or plasma extracted, and samples frozen at -80°C until testing. Duplicate samples were tested using a 19-plex feline cytokine/chemokine magnetic bead panel.Agreement between serum and plasma for many analytes was high, however correlation coefficients ranged from -0.01 to 0.97. Results from >50% of samples were below the lower limit of quantification for both serum and plasma for nine analytes, and for an additional three analytes for plasma only.While serum and plasma agreement was generally good, detection was improved using serum samples.}, journal={Veterinary Immunology and Immunopathology}, publisher={Elsevier BV}, author={Gruen, Margaret E. and Messenger, Kristen M. and Thomson, Andrea E. and Griffith, Emily H. and Paradise, Hayley and Vaden, Shelly and Lascelles, B.D.X.}, year={2016}, month={Dec}, pages={69–73} }
 @article{risselada_marcellin-little_messenger_griffith_davidson_papich_2016, title={Assessment of in vitro release of carboplatin from six carrier media}, volume={77}, ISSN={["1943-5681"]}, DOI={10.2460/ajvr.77.12.1381}, abstractNote={Abstract}, number={12}, journal={AMERICAN JOURNAL OF VETERINARY RESEARCH}, author={Risselada, Marije and Marcellin-Little, Denis J. and Messenger, Kristen M. and Griffith, Emily and Davidson, Gigi S. and Papich, Mark G.}, year={2016}, month={Dec}, pages={1381–1386} }
 @article{tuohy_lascelles_griffith_fogle_2016, title={Association of Canine Osteosarcoma and Monocyte Phenotype and Chemotactic Function}, volume={30}, ISSN={0891-6640}, url={http://dx.doi.org/10.1111/jvim.13983}, DOI={10.1111/jvim.13983}, abstractNote={BackgroundMonocytes/macrophages are likely key cells in immune modulation in dogs with osteosarcoma (OSA). Increased peripheral monocyte counts are negatively correlated with shorter disease‐free intervals in dogs with OSA. Understanding the monocyte/macrophage's modulatory role in dogs with OSA can direct further studies in immunotherapy development for OSA.}, number={4}, journal={Journal of Veterinary Internal Medicine}, publisher={Wiley}, author={Tuohy, J.L. and Lascelles, B.D.X. and Griffith, E.H. and Fogle, J.E.}, year={2016}, month={Jun}, pages={1167–1178} }
 @article{lewis_olby_early_mariani_muñana_seiler_griffith_2016, title={Clinical and Diagnostic Imaging Features of Brain Herniation in Dogs and Cats}, volume={30}, ISSN={0891-6640}, url={http://dx.doi.org/10.1111/jvim.14526}, DOI={10.1111/jvim.14526}, abstractNote={BackgroundQuantification of brain herniation on MRI and its immediate clinical implications are poorly described.}, number={5}, journal={Journal of Veterinary Internal Medicine}, publisher={Wiley}, author={Lewis, M.J. and Olby, N.J. and Early, P.J. and Mariani, C.L. and Muñana, K.R. and Seiler, G.S. and Griffith, E.H.}, year={2016}, month={Sep}, pages={1672–1680} }
 @article{jacob_crowell_fauls_griffith_ferris_2016, title={Diagnostic accuracy of a rapid immunoassay for point-of-care detection of urinary tract infection in dogs}, volume={77}, ISSN={["1943-5681"]}, DOI={10.2460/ajvr.77.2.162}, abstractNote={Abstract}, number={2}, journal={AMERICAN JOURNAL OF VETERINARY RESEARCH}, author={Jacob, Megan E. and Crowell, M. Denise and Fauls, Megan B. and Griffith, Emily H. and Ferris, Kelli K.}, year={2016}, month={Feb}, pages={162–166} }
 @article{olby_vaden_williams_griffith_harris_mariani_muñana_early_platt_boozer_et al._2016, title={Effect of Cranberry Extract on the Frequency of Bacteriuria in Dogs with Acute Thoracolumbar Disk Herniation: A Randomized Controlled Clinical Trial}, volume={31}, ISSN={0891-6640}, url={http://dx.doi.org/10.1111/jvim.14613}, DOI={10.1111/jvim.14613}, abstractNote={BackgroundDogs with spinal cord injury are at increased risk of developing bacteriuria due to increased residual urine volume. Cranberry extract inhibits binding of E. coli to uroepithelial cells, potentially reducing risk of bacteriuria.}, number={1}, journal={Journal of Veterinary Internal Medicine}, publisher={Wiley}, author={Olby, N.J. and Vaden, S.L. and Williams, K. and Griffith, E.H. and Harris, T. and Mariani, C.L. and Muñana, K.R. and Early, P.J. and Platt, S.R. and Boozer, L. and et al.}, year={2016}, month={Dec}, pages={60–68} }
 @article{risselada_mathews_griffith_2016, title={Effect of feline skin specimen preparation on postexcision and postfixation tissue shrinkage}, volume={18}, ISSN={["1532-2750"]}, DOI={10.1177/1098612x15602951}, abstractNote={Objectives This study was performed to assess skin–muscle–fascia specimen shrinkage and donor site changes, and to compare three techniques of specimen preparation for their effect on specimen shrinkage postexcision and after formalin fixation in feline cadaveric specimens. }, number={12}, journal={JOURNAL OF FELINE MEDICINE AND SURGERY}, author={Risselada, Marije and Mathews, Kyle G. and Griffith, Emily}, year={2016}, month={Dec}, pages={970–975} }
 @article{stevens_frantz_orlando_griffith_harden_gruen_sherman_2016, title={Efficacy of a single dose of trazodone hydrochloride given to cats prior to veterinary visits to reduce signs of transport- and examination-related anxiety}, volume={249}, ISSN={0003-1488}, url={http://dx.doi.org/10.2460/javma.249.2.202}, DOI={10.2460/javma.249.2.202}, abstractNote={Abstract}, number={2}, journal={Journal of the American Veterinary Medical Association}, publisher={American Veterinary Medical Association (AVMA)}, author={Stevens, Brenda J. and Frantz, Eva and Orlando, Jillian M. and Griffith, Emily and Harden, Lyndy and Gruen, Margaret E. and Sherman, Barbara L.}, year={2016}, month={Jul}, pages={202–207} }
 @article{nordberg_charoenpanich_vaughn_griffith_fisher_cole_spang_loboa_2016, title={Enhanced cellular infiltration of human adipose-derived stem cells in allograft menisci using a needle-punch method}, volume={11}, journal={Journal of Orthopaedic Surgery and Research}, author={Nordberg, R. C. and Charoenpanich, A. and Vaughn, C. E. and Griffith, E. H. and Fisher, M. B. and Cole, J. H. and Spang, J. T. and Loboa, E. G.}, year={2016} }
 @article{smith_marcellin-little_harrysson_griffith_2016, title={Influence of chondrodystrophy and brachycephaly on geometry of the humerus in dogs}, volume={29}, ISSN={["2567-6911"]}, DOI={10.3415/vcot-15-11-0181}, abstractNote={Summary}, number={3}, journal={VETERINARY AND COMPARATIVE ORTHOPAEDICS AND TRAUMATOLOGY}, author={Smith, Emily J. and Marcellin-Little, Denis J. and Harrysson, Ola L. A. and Griffith, Emily H.}, year={2016}, pages={220–226} }
 @article{cerda-gonzalez_olby_griffith_2016, title={Longitudinal Study of the Relationship among Craniocervical Morphology, Clinical Progression, and Syringomyelia in a Cohort of Cavalier King Charles Spaniels}, volume={30}, ISSN={0891-6640}, url={http://dx.doi.org/10.1111/jvim.14362}, DOI={10.1111/jvim.14362}, abstractNote={BackgroundCraniocervical junction (CCJ) anomalies and secondary syringomyelia are commonly diagnosed in Cavalier King Charles spaniel (CKCS). Familiarity with the natural history of these abnormalities is vital to understanding the disease syndrome.}, number={4}, journal={Journal of Veterinary Internal Medicine}, publisher={Wiley}, author={Cerda-Gonzalez, S. and Olby, N.J. and Griffith, E.H.}, year={2016}, month={Jun}, pages={1090–1098} }
 @article{gorney_blau_dohse_griffith_williams_lim_knazovicky_lascelles_olby_2016, title={Mechanical and Thermal Sensory Testing in Normal Chondrodystrophoid Dogs and Dogs with Spinal Cord Injury caused by Thoracolumbar Intervertebral Disc Herniations}, volume={30}, ISSN={0891-6640}, url={http://dx.doi.org/10.1111/jvim.13913}, DOI={10.1111/jvim.13913}, abstractNote={BackgroundIntervertebral disc herniation is a common cause of spinal cord injury (SCI) causing paralysis and sensory loss. Little quantitative information is available on the loss and recovery of sensation in dogs with SCI.}, number={2}, journal={Journal of Veterinary Internal Medicine}, publisher={Wiley}, author={Gorney, A.M. and Blau, S.R. and Dohse, C.S. and Griffith, E.H. and Williams, K.D. and Lim, J.-H. and Knazovicky, D. and Lascelles, B.D.X. and Olby, N.J.}, year={2016}, month={Mar}, pages={627–635} }
 @article{ward_defrancesco_tou_atkins_griffith_keene_2016, title={Outcome and survival in canine sick sinus syndrome and sinus node dysfunction: 93 cases (2002-2014)}, volume={18}, ISSN={["1875-0834"]}, DOI={10.1016/j.jvc.2016.04.004}, abstractNote={To evaluate the clinical presentation, diagnosis, treatment, and outcomes of a group of dogs with sinoatrial node abnormalities.Ninety-three client-owned dogs at a referral institution.Medical records were reviewed for clinical history, diagnostic testing, and medical or permanent artificial pacemaker (PAP) treatment. Owners or veterinarians were contacted for long-term follow-up.Sixty-one dogs were symptomatic for their bradyarrhythmia and were diagnosed with sick sinus syndrome (SSS). Thirty-two dogs were asymptomatic for their bradyarrhythmia and were diagnosed with sinus node dysfunction (SND). Miniature Schnauzers, West Highland White terriers, Cocker spaniels, and female dogs were overrepresented. Medical management with positive chronotropic drugs successfully controlled syncope long-term in 54% of SSS dogs, and acted as a bridge to PAP in 20%. Positive atropine response predicted medical treatment success. Forty-six percent of SSS dogs eventually underwent PAP implantation. Median survival time was approximately 18 months in SND and SSS dogs regardless of treatment strategy. Congestive heart failure (CHF) associated with progressive valvular heart disease occurred commonly in all groups, particularly in dogs with bradycardia-tachycardia syndrome.Sinus node dysfunction and SSS represent a spectrum of sinoatrial node disease, which for some dogs may also involve a component of autonomic dysfunction. Dogs with SND do not require treatment. Dogs with SSS often require treatment to reduce the frequency of syncope; medical management is often useful, particularly in atropine responsive dogs. Prognosis of SSS with treatment is good, though development of CHF does not appear to be mitigated by treatment.}, number={3}, journal={JOURNAL OF VETERINARY CARDIOLOGY}, author={Ward, J. L. and DeFrancesco, T. C. and Tou, S. P. and Atkins, C. E. and Griffith, E. H. and Keene, B. W.}, year={2016}, month={Sep}, pages={199–212} }
 @article{schreeg_marr_griffith_tarigo_bird_reichard_cohn_levy_birkenheuer_2016, title={PCR amplification of a multi-copy mitochondrial gene (cox3) improves detection of Cytauxzoon felis infection as compared to a ribosomal gene (18S)}, volume={225}, ISSN={["1873-2550"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-84975504702&partnerID=MN8TOARS}, DOI={10.1016/j.vetpar.2016.06.013}, abstractNote={Cytauxzoon felis is a tick-transmitted protozoan parasite that infects felids. Clinical disease caused by acute C. felis infection rapidly progresses in domestic cats, leading to high morbidity and mortality. Accurately diagnosing cytauxzoonosis as soon as possible during acute infection would allow for earlier initiation of antiprotozoal therapy which could lead to higher survival rates. Molecular detection of parasite rRNA genes (18S) by PCR has previously been shown to be a sensitive method of diagnosing C. felis infections. Based on evidence from related apicomplexan species, we hypothesized that C. felis mitochondrial genes would exist at higher copy numbers than 18S and would be a more sensitive diagnostic target. In this study we have designed a PCR assay targeting the C. felis mitochondrial gene cytochrome c oxidase subunit III (cox3). Herein we demonstrate that (1) the cox3 PCR can detect as low as 1 copy of DNA target and can detect C. felis in samples with known mitochondrial sequence heterogeneity, (2) cox3 copy number is increased relative to 18S in blood and tissue samples from acutely infected cats, and (3) the cox3 PCR is more sensitive than 18S PCR for detection of C. felis during early infections.}, journal={VETERINARY PARASITOLOGY}, author={Schreeg, Megan E. and Marr, Henry S. and Griffith, Emily H. and Tarigo, Jaime L. and Bird, David M. and Reichard, Mason V. and Cohn, Leah A. and Levy, Michael G. and Birkenheuer, Adam J.}, year={2016}, month={Jul}, pages={123–130} }
 @article{rousse_olby_williams_harris_griffith_mariani_muñana_early_2016, title={Recovery of stepping and coordination in dogs following acute thoracolumbar intervertebral disc herniations}, volume={213}, ISSN={1090-0233}, url={http://dx.doi.org/10.1016/J.TVJL.2016.04.002}, DOI={10.1016/J.TVJL.2016.04.002}, abstractNote={Prospective data on the recovery of coordination in dogs suffering acute thoracolumbar intervertebral disc herniations (TL-IVDH) are limited. The purpose of this study was to use treadmill based and open field scores (OFS) to quantify recovery of stepping ability and forelimb, hindlimb coordination in the 6 weeks following surgical decompression of dogs with TL-IVDH. Sixty-three dogs were grouped at presentation as grades 3 (non-ambulatory paraparetic), 4 (paraplegic) or 5 (paraplegic without pain sensation) and were evaluated 2, 4, and 6 weeks post-operatively. Stepping scores and Regularity Index (RI), a measure of coordination, were calculated from treadmill walking, and an OFS incorporating supported and unsupported walking was assigned. Outcomes for the three measures were compared between groups and correlation between scoring methods was assessed. Grade 3 and 4 dogs recovered ambulation by 2 weeks, reaching median stepping scores of 96 and 90% by 6 weeks, respectively. Recovery of coordination differed between groups 3 and 4 with median RI scores of 93.9% and 63%, respectively, by 6 weeks. Eight grade 5 dogs failed to recover independent ambulation by 6 weeks. Nine dogs recovered with scores that were significantly worse than the grade 3 and 4 dogs at 6 weeks for stepping score (P < 0.001) and RI (P < 0.001). OFS correlated closely with stepping and RI scores and each group was significantly different using this ordinal scale. In conclusion, recovery of coordination was incomplete in dogs that showed good recovery of stepping. The data generated could be used for clinical trial design.}, journal={The Veterinary Journal}, publisher={Elsevier BV}, author={Rousse, C.A. and Olby, N.J. and Williams, K. and Harris, T.L. and Griffith, E.H. and Mariani, C.L. and Muñana, K.R. and Early, P.J.}, year={2016}, month={Jul}, pages={59–63} }
 @article{risselada_mathews_griffith_2016, title={The effect of specimen preparation on post-excision and post-fixation dimensions, translation, and distortion of canine cadaver skin-muscle-fascia specimens}, volume={45}, DOI={10.1111/vsu.12481}, abstractNote={ObjectiveTo assess the effect of various tissue apposition techniques on specimens after formalin fixation, and to assess canine cadaveric composite skin‐muscle‐fascia specimen changes after excision without and with addition of a tumor model.}, number={5}, journal={Veterinary Surgery}, author={Risselada, M. and Mathews, K. G. and Griffith, E.}, year={2016}, pages={563–570} }
 @article{orlando_case_thomson_griffith_sherman_2016, title={Use of oral trazodone for sedation in cats: a pilot study}, volume={18}, ISSN={["1532-2750"]}, DOI={10.1177/1098612x15587956}, abstractNote={ObjectivesResistance to transportation and stressful veterinary visits are major causes for a decrease in feline veterinary care. Few options exist for oral sedatives to reduce cats’ anxiety prior to veterinary visits. The purpose of this study was to evaluate the safety and efficacy of oral trazodone for use as a single dose agent for sedation in cats.}, number={6}, journal={JOURNAL OF FELINE MEDICINE AND SURGERY}, author={Orlando, Jillian M. and Case, Beth C. and Thomson, Andrea E. and Griffith, Emily and Sherman, Barbara L.}, year={2016}, month={Jun}, pages={476–482} }
 @article{mcdonald-lynch_marcellin-little_roe_lascelles_trumpatori_griffith_2015, title={Assessment of an implant-skin interface scoring system for external skeletal fixation of dogs}, volume={76}, url={https://dx.doi.org/10.2460/ajvr.76.11.931}, DOI={10.2460/ajvr.76.11.931}, abstractNote={Abstract}, number={11}, journal={American Journal of Veterinary Research}, author={McDonald-Lynch, M. B. and Marcellin-Little, D. J. and Roe, Simon and Lascelles, B. Duncan X. and Trumpatori, B. J. and Griffith, E. H.}, year={2015}, pages={931–938} }
 @article{ward_defrancesco_tou_atkins_griffith_keene_2015, title={Complication Rates Associated with Transvenous Pacemaker Implantation in Dogs with High-Grade Atrioventricular Block Performed During versus After Normal Business Hours}, volume={29}, ISSN={["1939-1676"]}, DOI={10.1111/jvim.12512}, abstractNote={BackgroundTransvenous pacemaker implantation in dogs is associated with a relatively high complication rate. At our institution, pacemaker implantation in dogs with high‐grade atrioventricular block (HG‐AVB) frequently is performed as an after‐hours emergency.}, number={1}, journal={JOURNAL OF VETERINARY INTERNAL MEDICINE}, author={Ward, J. L. and DeFrancesco, T. C. and Tou, S. P. and Atkins, C. E. and Griffith, E. H. and Keene, B. W.}, year={2015}, pages={157–163} }
 @article{gruen_griffith_thomson_simpson_lascelles_2015, title={Criterion validation testing of clinical metrology instruments for measuring degenerative joint disease associated mobility impairment in cats}, volume={10}, number={7}, journal={PLoS One}, author={Gruen, M. E. and Griffith, E. H. and Thomson, A. E. and Simpson, W. and Lascelles, B. D. X.}, year={2015} }
 @article{cerda-gonzalez_olby_griffith_2015, title={Dorsal Compressive Atlantoaxial Bands and the Craniocervical Junction Syndrome: Association with Clinical Signs and Syringomyelia in Mature Cavalier King Charles Spaniels}, volume={29}, ISSN={0891-6640}, url={http://dx.doi.org/10.1111/jvim.12604}, DOI={10.1111/jvim.12604}, abstractNote={BackgroundDorsal compressive lesions at the atlantoaxial junction (ie, AA bands) occur in dogs with Chiari‐like malformations (CMs), but their clinical relevance is unclear.}, number={3}, journal={Journal of Veterinary Internal Medicine}, publisher={Wiley}, author={Cerda-Gonzalez, S. and Olby, N. J. and Griffith, E. H.}, year={2015}, month={May}, pages={887–892} }
 @article{risselada_ellison_winter_giglio_shih_hernandez_griffith_2015, title={In vitro evaluation of bursting pressure and intestinal luminal area of three jejunostomy tube placement techniques in dogs}, volume={76}, ISSN={["1943-5681"]}, DOI={10.2460/ajvr.76.5.467}, abstractNote={Abstract}, number={5}, journal={AMERICAN JOURNAL OF VETERINARY RESEARCH}, author={Risselada, Marije and Ellison, Gary W. and Winter, Matthew D. and Giglio, Robson F. and Shih, Andre and Hernandez, Jorge A. and Griffith, Emily}, year={2015}, month={May}, pages={467–474} }
 @article{cerda-gonzalez_olby_griffith_2015, title={Medullary Position at the Craniocervical Junction in Mature Cavalier King Charles Spaniels: Relationship with Neurologic Signs and Syringomyelia}, volume={29}, ISSN={0891-6640}, url={http://dx.doi.org/10.1111/jvim.12605}, DOI={10.1111/jvim.12605}, abstractNote={BackgroundMedullary elevation (ie, medullary kinking) at the craniocervical junction (CCJ) is reported in dogs with Chiari‐like malformations (CM), but its diagnostic criteria and clinical relevance are unclear.}, number={3}, journal={Journal of Veterinary Internal Medicine}, publisher={Wiley}, author={Cerda-Gonzalez, S. and Olby, N.J. and Griffith, E.H.}, year={2015}, month={Apr}, pages={882–886} }
 @article{risselada_mathews_griffith_2015, title={Surgically planned versus histologically measured lateral tumor margins for resection of cutaneous and subcutaneous mast cell tumors in dogs: 46 cases (2010-2013)}, volume={247}, ISSN={["1943-569X"]}, DOI={10.2460/javma.247.2.184}, abstractNote={Abstract}, number={2}, journal={JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION}, author={Risselada, Marije and Mathews, Kyle G. and Griffith, Emily}, year={2015}, month={Jul}, pages={184–189} }
 @article{bailey_minter_lewbart_harms_griffith_posner_2014, title={ALFAXALONE AS AN INTRAMUSCULAR INJECTABLE ANESTHETIC IN KOI CARP (CYPRINUS CARPIO)}, volume={45}, ISSN={1042-7260 1937-2825}, url={http://dx.doi.org/10.1638/2014-0056.1}, DOI={10.1638/2014-0056.1}, abstractNote={Abstract:  Fish are commonly anesthetized with MS-222 (tricaine methanesulfonate), a sodium-channel-blocker used as an immersion anesthetic, but its mechanism of action as a general anesthetic is uncertain. Alfaxalone is a neurosteroid that acts at the GABAA receptors. Alfaxalone has been evaluated and was deemed successful as an immersion agent in koi carp. Alfaxalone is an effective intramuscular anesthetic in multiple species. A reliable intramuscular anesthetic in fish would be useful in multiple settings. The purpose of this study was to investigate alfaxalone as an intramuscular injectable anesthetic agent in koi carp (Cyprinus carpio). Eight koi carp were utilized in a crossover design. In each trial, six fish received 1 mg/kg, 5 mg/kg, or 10 mg/kg of alfaxalone intramuscularly. They were assessed every 15 min for opercular rate and sedation score. The sedation score was based on a visual scale from 0 to 5, 0 indicating no response and 5 indicating absent righting reflex and anesthesia. Anesthetized koi were placed on a fish anesthesia delivery system (FADS). Time to anesthesia/recovery was recorded and heart rate was recorded every 15 min. Anesthesia was achieved in 0/6, 1/6, and 5/6 fish at 1, 5, and 10 mg/kg, respectively. Duration of anesthesia for one fish at 5 mg/kg was 2 hr. At 10 mg/kg, median anesthesia duration was 6.5 (3–10) hr. At 10 mg/kg, prolonged apnea (2–3 hr) was observed in 3/6 fish, 2/3 died under anesthesia, and 1/3 recovered 10 hr post-injection. Median peak sedation scores were 1.5, 2.5, and 5, at 1, 5, and 10 mg/kg, respectively. A dosage of 10 mg/kg alfaxalone resulted in 33% mortality. The duration of anesthesia and opercular rate were unpredictable. Due to variation in response despite consistent conditions, as well as risk of mortality, intramuscular alfaxalone cannot be recommended for anesthesia in koi carp.}, number={4}, journal={Journal of Zoo and Wildlife Medicine}, publisher={American Association of Zoo Veterinarians}, author={Bailey, Kate M. and Minter, Larry J. and Lewbart, Gregory A. and Harms, Craig A. and Griffith, Emily H. and Posner, Lysa P.}, year={2014}, month={Dec}, pages={852–858} }
 @article{gruen_griffith_thomson_simpson_lascelles_2014, title={Detection of Clinically Relevant Pain Relief in Cats with Degenerative Joint Disease Associated Pain}, volume={28}, ISSN={["1939-1676"]}, url={https://dx.doi.org/10.1111/jvim.12312}, DOI={10.1111/jvim.12312}, abstractNote={BackgroundDetection of clinically relevant pain relief in cats with degenerative joint disease (DJD) is complicated by a lack of validated outcome measures and a placebo effect.}, number={2}, journal={JOURNAL OF VETERINARY INTERNAL MEDICINE}, author={Gruen, M. E. and Griffith, E. and Thomson, A. and Simpson, W. and Lascelles, B. D. X.}, year={2014}, month={Mar}, pages={346–350} }
 @article{tuohy_marcellin-little_griffith_2014, title={Durations of Bone Consolidation and External Fixation After Distraction Osteogenesis in Dogs}, volume={43}, ISSN={["1532-950X"]}, DOI={10.1111/j.1532-950x.2014.12189.x}, abstractNote={ObjectiveTo evaluate the influence of epidemiologic, surgical, and mechanical factors on the durations of bone consolidation and external fixation after distraction osteogenesis in dogs.}, number={8}, journal={VETERINARY SURGERY}, author={Tuohy, Joanne L. and Marcellin-Little, Denis J. and Griffith, Emily H.}, year={2014}, month={Nov}, pages={903–911} }
 @article{briley_williams_freire_griffith_lascelles_2014, title={Feasibility and repeatability of cold and mechanical quantitative sensory testing in normal dogs}, volume={199}, ISSN={["1532-2971"]}, url={https://dx.doi.org/10.1016/j.tvjl.2013.10.025}, DOI={10.1016/j.tvjl.2013.10.025}, abstractNote={Feasibility and inter-session repeatability of cold and mechanical quantitative sensory testing (QST) were assessed in 24 normal dogs. Cold thermal latencies were evaluated using a thermal probe (0°C) applied to three pelvic limb sites. Mechanical thresholds were measured using an electronic von Frey anesthesiometer (EVF) and a blunt-probed pressure algometer (PA) applied to the dorsal aspect of the metatarsus. All QST trials were performed with dogs in lateral recumbency. Collection of cold QST data was easy (feasible) in 19/24 (79%) dogs. However, only 18.4%, 18.9% and 13.2% of cold QST trials elicited a response at the medial tibia, third digital pad and plantar metatarsal regions, respectively. Collection of mechanical QST data was easy (feasible) in 20/24 (83%) dogs for both EVF and PA. At consecutive sampling times, approximately 2 weeks apart, the average EVF sensory thresholds were 414 ± 186 g and 379 ± 166 g, respectively, and the average PA sensory thresholds were 1089 ± 414 g and 1028 ± 331 g, respectively. There was no significant difference in inter-session or inter-limb threshold values for either mechanical QST device. The cold QST protocol in this study was achievable, but did not provide consistently quantifiable results. Both mechanical QST devices tested provided repeatable, reliable sensory threshold measurements in normal, client-owned dogs. These findings contribute to the validation of the EVF and PA as tools to obtain repeated QST data over time in dogs to assess somatosensory processing changes.}, number={2}, journal={VETERINARY JOURNAL}, author={Briley, Jessica D. and Williams, Morika D. and Freire, Mila and Griffith, Emily H. and Lascelles, B. Duncan X.}, year={2014}, month={Feb}, pages={245–250} }
 @article{williams_kirkpatrick_griffith_benito_hash_lascelles_2014, title={Feasibility and repeatability of thermal quantitative sensory testing in normal dogs and dogs with hind limb osteoarthritis-associated pain}, volume={199}, ISSN={["1532-2971"]}, url={https://dx.doi.org/10.1016/j.tvjl.2013.11.003}, DOI={10.1016/j.tvjl.2013.11.003}, abstractNote={The objectives of this study were to determine whether thermal quantitative sensory testing (QST) can be performed in client-owned dogs, is repeatable and whether QST differs between normal dogs and dogs with hind limb osteoarthritis (OA). This clinical, prospective, observational study used clinically normal dogs (n = 23) and dogs with OA-associated hind limb pain (n = 9). Thermal QST was performed in standing dogs using a high-powered light source delivered by a previously validated system. Dogs were tested on two occasions, 2 weeks apart. Five tests were performed on each hind limb at each time point. Repeated measures analysis of variance was used to evaluate the effects of leg, time point and OA/normal status on thermal threshold latencies (TTL). Additionally, paired t tests were used to compare the TTL of left and right limbs within groups and between time points. Thermal thresholds were successfully measured in 32 client-owned dogs without prior training. TTL were significantly different between normal and OA dogs (P = 0.012). There was no difference between limbs (P = 0.744) or time periods (P = 0.572), when analyzed by repeated measures analysis of variance, and no interactions between group and limb, visit and limb, or visit and group. In conclusion, thermal thresholds can be measured in client owned dogs with no prior training and are repeatable from week to week. Further data are required to determine if OA results in thermal hypoalgesia as measured at the distal hind limb and whether this is an indication of central sensitization.}, number={1}, journal={VETERINARY JOURNAL}, author={Williams, Morika D. and Kirkpatrick, Amy E. and Griffith, Emily and Benito, Javier and Hash, Jon and Lascelles, B. D. X.}, year={2014}, month={Jan}, pages={63–67} }
 @article{oda_bailey_lewbart_griffith_posner_2014, title={Physiologic and biochemical assessments of koi (Cyprinus carpio) following immersion in propofol}, volume={245}, ISSN={["1943-569X"]}, DOI={10.2460/javma.245.11.1286}, abstractNote={Abstract}, number={11}, journal={JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION}, author={Oda, Ayako and Bailey, Kate M. and Lewbart, Gregory A. and Griffith, Emily H. and Posner, Lysa P.}, year={2014}, month={Dec}, pages={1286–1291} }
 @article{gruen_roe_griffith_hamilton_sherman_2014, title={Use of trazodone to facilitate postsurgical confinement in dogs}, volume={245}, ISSN={["1943-569X"]}, DOI={10.2460/javma.245.3.296}, abstractNote={Abstract}, number={3}, journal={JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION}, author={Gruen, Margaret E. and Roe, Simon C. and Griffith, Emily and Hamilton, Alexandra and Sherman, Barbara L.}, year={2014}, month={Aug}, pages={296–301} }
 @misc{roe_sherman_gruen_hamilton_griffith_2014, title={Use of trazodone to facilitate postsurgical confinement in dogs Response}, volume={245}, number={6}, journal={Journal of the American Veterinary Medical Association}, author={Roe, S. C. and Sherman, B. L. and Gruen, M. E. and Hamilton, A. and Griffith, E.}, year={2014}, pages={629–630} }
 @article{fonseca_kenworth_griffith_hall_finkbeiner_bell_2008, title={Factors influencing landscape pattern of the seagrass Halophila decipiens in an oceanic setting}, volume={76}, ISSN={["1096-0015"]}, DOI={10.1016/j.ecss.2007.06.014}, abstractNote={The scale of landscape pattern formation of an ecological community may provide clues as to the processes influencing its spatial and temporal dynamics. We conducted an examination of the spatial organization of an annual seagrass (Halophila decipiens) in an open ocean setting at two spatial scales and growing seasons to identify the relative influence of external (hurricanes) versus internal (clonal growth) factors. Visual surveys of seagrass cover were conducted over 2 years within three replicate 1 km2 study areas each separated by ∼25 km in an inshore–offshore transect along the southwest coast of Florida at depths between ∼10 and 30 m. A towed video sled allowed observations of seagrass cover of 1 m2 areas approximately every 6 m over thousands of meters of evenly spaced transects within the study areas (coarse scale). The towed video revealed that 17.5% of the seafloor was disturbed irrespective of location or sample time. Randomly selected 10 × 10 m quadrats within the larger, 1 km2 study areas were completely surveyed for seagrass cover by divers at 0.625 m2 resolution (fine scale). The coarse-scale observations were tested using both conventional geostatistics and an application of a time-series technique (Runs test) for scale of seagrass cover contiguity. Fine-scale observations were examined using conventional geostatistics and a least squares approach (cumulative logistic). The coarse-scale observations revealed little scale dependency and indicated that the structure was organized at spatial extents finer than our sample spacing; the cumulative logistic technique revealed potential fine-scale patterns not otherwise discerned. In contrast, surveys of the 10 × 10 m quadrats detected strong scale dependency with multiple small gaps, indicating scale-dependent patterns arising from processes operating at extents generally <14 m. Between June and October 1999, a Category I hurricane passed over the study area, rearranging large areas of sand that uncovered some rocky hard bottom areas, while covering others; by the next growing season the newly covered areas were vegetated with Halophila decipiens that likely arose from transported seeds. Spatial analysis revealed that the storm led to a shift to greater frequency of H. decipiens, but lower density coverage. Seagrass density remained substantially depressed in all areas a full year following the storm. The short life history of H. decipiens and the apparent existence of a moveable seed bank means that spatial organization of this community is dictated first by large-scale dispersal of plant propagules (hundreds of meters) and then within a growing season, by clonal organization of the seagrass operating over very small distances (m). The two techniques (semivariance and Runs test) led to similar conclusions regarding the organizational scales of seagrass landscape pattern. As with terrestrial examples, this study demonstrates the importance of selecting the appropriate scale for detection of landscape pattern and processes influencing population ecology of a seagrass ecosystem.}, number={1}, journal={ESTUARINE COASTAL AND SHELF SCIENCE}, author={Fonseca, Mark S. and Kenworth, W. Judson and Griffith, Emily and Hall, Margaret O. and Finkbeiner, Mark and Bell, Susan S.}, year={2008}, month={Jan}, pages={163–174} }