Works (71)

Updated: August 22nd, 2023 21:22

2021 article

The evaluation of a multiphasic 3D-bioplotted scaffold seeded with adipose derived stem cells to repair osteochondral defects in a porcine model

Nordberg, R. C., Huebner, P., Schuchard, K. G., Mellor, L. F., Shirwaiker, R. A., Loboa, E. G., & Spang, J. T. (2021, June 10). JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, Vol. 6.

By: R. Nordberg n, P. Huebner n, K. Schuchard n, L. Mellor n, R. Shirwaiker n, E. Loboa*, J. Spang*

author keywords: in vivo; osteochondral; stem cells; tissue engineering; 3D-printing
MeSH headings : Animals; Cartilage, Articular / injuries; Stem Cells; Swine; Swine, Miniature; Tissue Engineering / methods; Tissue Scaffolds / chemistry
Sources: Web Of Science, ORCID
Added: June 21, 2021

2020 journal article

Developing Implantable Scaffolds to Enhance Neural Stem Cell Therapy for Post-Operative Glioblastoma

MOLECULAR THERAPY, 28(4), 1056–1067.

By: K. Sheets*, M. Ewend*, M. Mohiti-Asli n, S. Tuin n, E. Loboa*, K. Aboody*, S. Hingtgen*

MeSH headings : Animals; Brain Neoplasms / pathology; Brain Neoplasms / surgery; Brain Neoplasms / therapy; Cell Line, Tumor; Combined Modality Therapy; Ganciclovir / administration & dosage; Ganciclovir / pharmacology; Glioblastoma / pathology; Glioblastoma / surgery; Glioblastoma / therapy; Humans; Luminescent Measurements; Mice; Neural Stem Cells / metabolism; Neural Stem Cells / transplantation; Polyesters / chemistry; Prodrugs / administration & dosage; Prodrugs / pharmacology; Thymidine Kinase / metabolism; Tissue Scaffolds / chemistry; Treatment Outcome; Xenograft Model Antitumor Assays
Source: Web Of Science
Added: April 27, 2020

2020 journal article

Investigation of multiphasic 3D-bioplotted scaffolds for site-specific chondrogenic and osteogenic differentiation of human adipose-derived stem cells for osteochondral tissue engineering applications

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 108(5), 2017–2030.

By: L. Mellor n, R. Nordberg n, P. Huebner n, M. Mohiti-Asli n, M. Taylor n, W. Efird*, J. Oxford*, J. Spang*, R. Shirwaiker n, E. Loboa*

author keywords: 3D-printing; chondrogenic differentiation; human adipose derived stem cells; osteochondral; osteogenic differentiation
MeSH headings : Adipose Tissue / metabolism; Biocompatible Materials / chemistry; Bone and Bones; Calcium Phosphates / chemistry; Calcium Phosphates / metabolism; Cartilage, Articular / metabolism; Cell Differentiation; Cells, Cultured; Chondrogenesis / physiology; Collagen Type I / genetics; Collagen Type I / metabolism; Extracellular Matrix / chemistry; Extracellular Matrix / metabolism; Humans; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; Osteogenesis / physiology; Polyesters / chemistry; Polyesters / metabolism; Printing, Three-Dimensional; Tissue Engineering; Tissue Scaffolds / chemistry
Sources: Web Of Science, ORCID
Added: January 6, 2020

2019 journal article

Evidence for Aryl hydrocarbon Receptor-Mediated Inhibition of Osteoblast Differentiation in Human Mesenchymal Stem Cells

TOXICOLOGICAL SCIENCES, 167(1), 145–156.

By: A. Watson n, R. Nordberg n, E. Loboa n & S. Kullman n

author keywords: aryl hydrocarbon receptor; 2,3,7,8-tetrachlorodibenzo-p-dioxin; TCDD; mesenchymal stem cell; osteoblast differentiation; skeletal toxicity; bone toxicity
MeSH headings : Basic Helix-Loop-Helix Transcription Factors / agonists; Cell Differentiation / drug effects; Fibroblast Growth Factor 9 / genetics; Fibroblast Growth Factors / genetics; Humans; Ligands; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / drug effects; Mesenchymal Stem Cells / metabolism; Osteoblasts / cytology; Osteoblasts / drug effects; Osteoblasts / metabolism; Osteogenesis / drug effects; Osteogenesis / genetics; Polychlorinated Dibenzodioxins / toxicity; Receptors, Aryl Hydrocarbon / agonists; Up-Regulation
Sources: Web Of Science, ORCID
Added: April 15, 2019

2019 journal article

Industrial-scale fabrication of an osteogenic and antibacterial PLA/silver-loaded calcium phosphate composite with significantly reduced cytotoxicity

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 107(4), 900–910.

By: S. Cai n, B. Pourdeyhimi n & E. Loboa*

author keywords: industrial-scale fabrication; multifunctional scaffold; osteogenic; antibacterial; reduced cytotoxicity
MeSH headings : Adipose Tissue / cytology; Adipose Tissue / metabolism; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Calcium Phosphates / chemistry; Calcium Phosphates / pharmacology; Cell Differentiation / drug effects; Escherichia coli / growth & development; Humans; Osteogenesis / drug effects; Polyesters / chemical synthesis; Polyesters / chemistry; Polyesters / pharmacology; Silver / chemistry; Silver / pharmacology; Staphylococcus aureus / growth & development; Stem Cells / cytology; Stem Cells / metabolism; Tissue Scaffolds / chemistry
Sources: Web Of Science, ORCID
Added: April 22, 2019

2019 journal article

Primary Cilia Exhibit Mechanosensitivity to Cyclic Tensile Strain and Lineage-Dependent Expression in Adipose-Derived Stem Cells

SCIENTIFIC REPORTS, 9.

By: J. Bodle n, M. Hamouda n, S. Cai n, R. Williams n, S. Bernacki n & E. Loboa n

MeSH headings : Adipocytes / cytology; Adipocytes / metabolism; Adipogenesis / genetics; Cell Differentiation / genetics; Cell Lineage / genetics; Cells, Cultured; Cilia / genetics; Core Binding Factor Alpha 1 Subunit / genetics; Gene Expression Regulation, Developmental / genetics; Humans; Mechanotransduction, Cellular / genetics; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; Osteogenesis / genetics; Tensile Strength; Tissue Engineering
Source: Web Of Science
Added: June 17, 2019

2018 article

Mechanical Stimulation of Adipose-Derived Stem Cells for Functional Tissue Engineering of the Musculoskeletal System via Cyclic Hydrostatic Pressure, Simulated Microgravity, and Cyclic Tensile Strain

ADIPOSE-DERIVED STEM CELLS: METHODS AND PROTOCOLS, 2ND EDITION, Vol. 1773, pp. 215–230.

By: R. Nordberg, J. Bodle & E. Loboa*

author keywords: Adipose-derived stem cells; Tissue engineering; Mechanical stimulation; Tensile strain; Hydrostatic pressure; Microgravity; Differentiation; Osteogenesis; Chondrogenesis; Adipogenesis; Protocols; Methods
MeSH headings : Adipose Tissue / cytology; Cell Differentiation; Chondrogenesis; Humans; Hydrostatic Pressure; Mesenchymal Stem Cells / cytology; Musculoskeletal System; Osteogenesis; Primary Cell Culture; Stress, Mechanical; Tensile Strength; Tissue Engineering / methods; Weightlessness Simulation
Source: Web Of Science
Added: October 16, 2018

2017 journal article

Creation and Evaluation of New Porcine Model for Investigation of Treatments of Surgical Site Infection

TISSUE ENGINEERING PART C-METHODS, 23(11), 795–803.

By: M. Mohiti-Asli n, M. Risselada n, M. Jacob n, B. Pourdeyhimi n & E. Loboa n

author keywords: surgical site infection; porcine model; antimicrobial scaffold; silver; electrospinning; MRSA
MeSH headings : Animals; Anti-Infective Agents / pharmacology; Anti-Infective Agents / therapeutic use; Disease Models, Animal; Female; Methicillin-Resistant Staphylococcus aureus / drug effects; Nanofibers / chemistry; Nanofibers / ultrastructure; Polyesters / chemistry; Porosity; Surgical Wound Infection / drug therapy; Surgical Wound Infection / microbiology; Surgical Wound Infection / pathology; Sus scrofa; Tissue Scaffolds / chemistry
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Effects of 3D-bioplotted polycaprolactone scaffold geometry on human adipose-derived stem cell viability and proliferation

RAPID PROTOTYPING JOURNAL, 23(3), 534–542.

By: S. Mehendale n, L. Mellor n, M. Taylor n, E. Loboa n & R. Shirwaiker n

author keywords: 3D-Bioplotting; Human adipose-derived stem cells; Polycaprolactone; Tissue engineering scaffolds
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2017 journal article

Electrical Cell-Substrate Impedance Spectroscopy Can Monitor Age-Grouped Human Adipose Stem Cell Variability During Osteogenic Differentiation

STEM CELLS TRANSLATIONAL MEDICINE, 6(2), 502–511.

By: R. Nordberg n, J. Zhang n, E. Griffith n, M. Frank n, B. Starly n & E. Loboa n

author keywords: Electrical cell-substrate impedance spectroscopy; Adipose stem cells; Osteogenesis; Bioimpedance
MeSH headings : Adipose Tissue / cytology; Adult; Age Factors; Aged; Aged, 80 and over; Bone and Bones / cytology; Cell Differentiation; Cell Proliferation; Cells, Cultured; Dielectric Spectroscopy / methods; Electric Impedance; Humans; Middle Aged; Osteogenesis; Phenotype; Stem Cells / metabolism; Stem Cells / physiology; Time Factors; Young Adult
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Ibuprofen loaded PLA nanofibrous scaffolds increase proliferation of human skin cells in vitro and promote healing of full thickness incision wounds in vivo

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 105(2), 327–339.

By: M. Mohiti-Asli n, S. Saha n, S. Murphy*, H. Gracz n, B. Pourdeyhimi n, A. Atala*, E. Loboa n

author keywords: controlled release; drug delivery/release; inflammation; PLLA; wound healing
MeSH headings : Animals; Dermis / injuries; Dermis / metabolism; Dermis / pathology; Drug Carriers / chemistry; Drug Carriers / pharmacokinetics; Drug Carriers / pharmacology; Fibroblasts / metabolism; Fibroblasts / pathology; Humans; Ibuprofen / chemistry; Ibuprofen / pharmacokinetics; Ibuprofen / pharmacology; Keratinocytes / metabolism; Keratinocytes / pathology; Mice, Nude; Nanofibers / chemistry; Nanofibers / therapeutic use; Polyesters / chemistry; Polyesters / pharmacokinetics; Polyesters / pharmacology; Wound Healing / drug effects
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

A Novel Ultrasound Technique for Non-Invasive Assessment of Cell Differentiation

IEEE SENSORS JOURNAL, 16(1), 61–68.

By: W. Huang*, J. Kim n, K. Kim n, S. Bakshi n, J. Williams n, P. Matthieu n, E. Loboa n, K. Shung*, Q. Zhou*, X. Jiang n

author keywords: Lead magnesium niobate-lead titanate piezoelectric resonator; in-situ cell differentiation monitoring; electrical impedance measurement; osteogenic differentiation
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Cell signaling in tenocytes: Response to load and ligands in health and disease

Metabolic Influences on Risk for Tendon Disorders, 920, 79–95.

By: M. Wall, N. Dyment, J. Bodle, J. Volmer, E. Loboa, A. Cederlund, A. Fox, A. Banes

Source: NC State University Libraries
Added: August 6, 2018

2016 review

Concise Review: Primary Cilia: Control Centers for Stem Cell Lineage Specification and Potential Targets for Cell-Based Therapies

[Review of ]. STEM CELLS, 34(6), 1445–1454.

By: J. Bodle n & E. Loboa n

author keywords: Primary cilia; Tissue regeneration; Adipose stem cells; Bone marrow stromal cells; Cell biology; Stem cell-microenvironment interactions; Cellular therapy; Progenitor cells
MeSH headings : Animals; Cell Lineage; Cilia / metabolism; Disease Models, Animal; Humans; Mechanotransduction, Cellular; Stem Cell Transplantation; Stem Cells / cytology; Stem Cells / metabolism
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Creating tissues from textiles: scalable nonwoven manufacturing techniques for fabrication of tissue engineering scaffolds

BIOMEDICAL MATERIALS, 11(1).

By: S. Tuin n, B. Pourdeyhimi n & E. Loboa n

author keywords: human adipose derived stem cells; nonwoven tissue engineering scaffolds; scalable tissue engineering
MeSH headings : Adipogenesis / physiology; Biocompatible Materials / chemical synthesis; Cell Differentiation / physiology; Cell Survival / physiology; Cells, Cultured; Equipment Design; Equipment Failure Analysis; Humans; Lactic Acid / chemistry; Materials Testing; Osteogenesis / physiology; Polyesters; Polymers / chemistry; Stem Cells / cytology; Stem Cells / physiology; Textiles; Tissue Engineering / instrumentation; Tissue Engineering / methods; Tissue Scaffolds
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

Electrospun nanofibrous scaffolds increase the efficacy of stem cell-mediated therapy of surgically resected glioblastoma

BIOMATERIALS, 90, 116–125.

By: J. Bago*, G. Pegna*, O. Okolie*, M. Mohiti-Asli n, E. Loboa n & S. Hingtgen*

author keywords: Cytotoxic stem cell; Electrospun nanofibrous scaffolds; Surgical resection; Cancer; Molecular imaging
MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / therapeutic use; Brain / pathology; Brain / surgery; Brain Neoplasms / pathology; Brain Neoplasms / surgery; Brain Neoplasms / therapy; Cell Line; Cell Line, Tumor; Drug Delivery Systems / methods; Glioblastoma / pathology; Glioblastoma / surgery; Glioblastoma / therapy; Humans; Mice, Nude; Nanofibers / chemistry; Nanofibers / ultrastructure; Polyesters / chemistry; Stem Cell Transplantation / methods; Stem Cells / cytology; Tissue Scaffolds / chemistry
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Evaluation of Silver Ion-Releasing Scaffolds in a 3D Coculture System of MRSA and Human Adipose-Derived Stem Cells for Their Potential Use in Treatment or Prevention of Osteomyelitis

TISSUE ENGINEERING PART A, 22(21-22), 1258–1263.

By: M. Mohiti-Asli n, C. Molina n, T. Diteepeng*, B. Pourdeyhimi n & E. Loboa n

author keywords: nanofiber; antimicrobial; coculture; osteomyelitis
MeSH headings : Adipose Tissue / metabolism; Cell Differentiation / drug effects; Coculture Techniques; Humans; Methicillin-Resistant Staphylococcus aureus / growth & development; Osteogenesis / drug effects; Osteomyelitis / prevention & control; Silver / chemistry; Silver / pharmacokinetics; Silver / pharmacology; Stem Cells / metabolism; Tissue Scaffolds / chemistry
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

Fabrication of novel high surface area mushroom gilled fibers and their effects on human adipose derived stem cells under pulsatile fluid flow for tissue engineering. applications

ACTA BIOMATERIALIA, 36, 220–230.

By: S. Tuin n, B. Pourdeyhimi n & E. Loboa n

author keywords: Gilled high surface area fibers; Human adipose derived stem cells; Pulsatile fluid slow; Shear stress; Scalable tissue engineering scaffolds
MeSH headings : Adipose Tissue / cytology; Adipose Tissue / metabolism; Agaricales; Cells, Cultured; Humans; Pulsatile Flow; Stem Cells / cytology; Stem Cells / metabolism; Tissue Engineering / instrumentation; Tissue Engineering / methods; Tissue Scaffolds / chemistry
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

Facilitating Teamwork in Adolescent and Young Adult Oncology

JOURNAL OF ONCOLOGY PRACTICE, 12(11), 1067-+.

MeSH headings : Adolescent; Adult; Communication; Cooperative Behavior; Humans; Interprofessional Relations; Male; Patient Care Team / organization & administration; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / drug therapy; Trust; Young Adult
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

Mechanical and Vascular Cues Synergistically Enhance Osteogenesis in Human Mesenchymal Stem Cells

TISSUE ENGINEERING PART A, 22(15-16), 997–1005.

By: A. Steward n, J. Cole n, F. Ligler n & E. Loboa n

MeSH headings : Adolescent; Adult; Antigens, Differentiation / biosynthesis; Coculture Techniques; Endothelial Cells / cytology; Endothelial Cells / metabolism; Female; Humans; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; Neovascularization, Physiologic; Osteogenesis
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Continuous-wave stimulated emission depletion microscope for imaging actin cytoskeleton in fixed and live cells

Sensors (Basel, Switzerland), 15(9), 24178–24190.

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Extracellular Calcium Modulates Chondrogenic and Osteogenic Differentiation of Human Adipose-Derived Stem Cells: A Novel Approach for Osteochondral Tissue Engineering Using a Single Stem Cell Source

TISSUE ENGINEERING PART A, 21(17-18), 2323–2333.

By: L. Mellor n, M. Mohiti-Asli n, J. Williams n, A. Kannan n, M. Dent n, F. Guilak*, E. Loboa n

MeSH headings : Adipose Tissue / cytology; Adult; Calcification, Physiologic / drug effects; Calcium / pharmacology; Calcium Phosphates / pharmacology; Cell Differentiation / drug effects; Cells, Cultured; Chondrogenesis / drug effects; Extracellular Space / chemistry; Gene Expression Regulation / drug effects; Glycosaminoglycans / metabolism; Humans; Immunohistochemistry; Lactic Acid / pharmacology; Osteogenesis / drug effects; Polyesters; Polymers / pharmacology; Stem Cells / cytology; Stem Cells / drug effects; Stem Cells / ultrastructure; Tissue Engineering / methods; Tissue Scaffolds; Young Adult
Source: Web Of Science
Added: August 6, 2018

2015 review

Naturally derived and synthetic scaffolds for skeletal muscle reconstruction

[Review of ]. ADVANCED DRUG DELIVERY REVIEWS, 84, 208–221.

By: M. Wolf*, C. Dearth*, S. Sonnenberg n, E. Loboa n & S. Badylak*

author keywords: Extracellular matrix (ECM); Electrospinning; Hybrid materials; Hydrogel; Mesh; Volumetric muscle loss (VML)
MeSH headings : Biocompatible Materials / administration & dosage; Humans; Muscle, Skeletal / physiology; Polymers / administration & dosage; Regeneration / physiology; Tissue Engineering / methods; Tissue Scaffolds
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Our Fat Future: Translating Adipose Stem Cell Therapy

STEM CELLS TRANSLATIONAL MEDICINE, 4(9), 974–979.

By: R. Nordberg n & E. Loboa n

MeSH headings : Adipocytes / cytology; Adipocytes / physiology; Adipose Tissue / cytology; Adipose Tissue / physiology; Automation, Laboratory / instrumentation; Biomimetic Materials / chemistry; Biosensing Techniques / instrumentation; Cell Differentiation; Cell- and Tissue-Based Therapy / methods; Clinical Trials as Topic; Humans; Stem Cell Transplantation / methods; Stem Cells / cytology; Stem Cells / physiology; Translational Research, Biomedical / legislation & jurisprudence; Translational Research, Biomedical / trends; United States; United States Food and Drug Administration / legislation & jurisprudence; Workforce
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Translating textiles to tissue engineering: Creation and evaluation of microporous, biocompatible, degradable scaffolds using industry relevant manufacturing approaches and human adipose derived stem cells

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 103(5), 1050–1058.

By: C. Haslauer n, M. Avery n, B. Pourdeyhimi n & E. Loboa n

author keywords: porous scaffolds; bone tissue engineering; Islands-In-The-Sea; human adipose-derived stem cells
MeSH headings : Absorbable Implants; Adipose Tissue / cytology; Adipose Tissue / metabolism; Cell Differentiation; Cells, Cultured; Humans; Materials Testing; Osteogenesis; Porosity; Stem Cells / cytology; Stem Cells / metabolism; Textiles; Tissue Engineering; Tissue Scaffolds / chemistry
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Age-Related Effects on the Potency of Human Adipose-Derived Stem Cells: Creation and Evaluation of Superlots and Implications for Musculoskeletal Tissue Engineering Applications

Tissue Engineering Part C: Methods, 20(12), 972–983.

By: J. Bodle n, S. Teeter n, B. Hluck n, J. Hardin n, S. Bernacki n & E. Loboa n

MeSH headings : Adipogenesis; Adipose Tissue / cytology; Adult; Aged; Aged, 80 and over; Aging / physiology; Cell Line; Cell Proliferation; Cell Separation; DNA / metabolism; Female; Humans; Middle Aged; Musculoskeletal System / metabolism; Osteogenesis; Postmenopause; Premenopause; Proteins / metabolism; Reproducibility of Results; Stem Cells / cytology; Tissue Engineering / methods; Young Adult
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2014 journal article

Cyclic Tensile Strain Enhances Osteogenesis and Angiogenesis in Mesenchymal Stem Cells from Osteoporotic Donors

TISSUE ENGINEERING PART A, 20(1-2), 67–78.

By: A. Charoenpanich n, M. Wall n, C. Tucker*, D. Andrews*, D. Lalush n, D. Dirschl*, E. Loboa n

MeSH headings : Aged, 80 and over; Calcium / metabolism; Cell Differentiation; Cell Proliferation; Cell Separation; Female; Gene Expression Regulation; Gene Regulatory Networks; Humans; Mesenchymal Stem Cells / metabolism; Mesenchymal Stem Cells / pathology; Neovascularization, Physiologic / genetics; Oligonucleotide Array Sequence Analysis; Osteogenesis / genetics; Osteoporosis, Postmenopausal / genetics; Osteoporosis, Postmenopausal / pathology; Proto-Oncogene Mas; Real-Time Polymerase Chain Reaction; Signal Transduction / genetics; Stress, Mechanical; Tensile Strength; Tissue Donors; White People
Source: Web Of Science
Added: August 6, 2018

2014 review

Interconnected, microporous hollow fibers for tissue engineering: Commercially relevant, industry standard scale-up manufacturing

[Review of ]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 102(9), 3311–3323.

By: S. Tuin n, B. Pourdeyhimi n & E. Loboa n

author keywords: spunbond process; hollow porous fibers; industry standard scale-up manufacturing; tissue engineering; stem cells
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Novel, silver-ion-releasing nanofibrous scaffolds exhibit excellent antibacterial efficacy without the use of silver nanoparticles

ACTA BIOMATERIALIA, 10(5), 2096–2104.

By: M. Mohiti-Asli n, B. Pourdeyhimi n & E. Loboa n

author keywords: Antimicrobial; Silver; Biocompatibility; Wound dressing; Nanofibers
MeSH headings : Adult; Anti-Bacterial Agents / pharmacology; Biocompatible Materials / pharmacology; Cell Proliferation / drug effects; Cell Shape / drug effects; Cell Survival / drug effects; Dermis / cytology; Epidermal Cells; Escherichia coli / drug effects; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / ultrastructure; Humans; Ions; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / ultrastructure; Lactic Acid / chemistry; Mass Spectrometry; Metal Nanoparticles / chemistry; Microbial Sensitivity Tests; Nanofibers / chemistry; Nanofibers / ultrastructure; Photoelectron Spectroscopy; Polyesters; Polymers / chemistry; Silver / pharmacology; Staphylococcus aureus / drug effects; Tissue Scaffolds / chemistry
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Primary cilium mechanotransduction of tensile strain in 3D culture: Finite element analyses of strain amplification caused by tensile strain applied to a primary cilium embedded in a collagen matrix

JOURNAL OF BIOMECHANICS, 47(9), 2211–2217.

By: P. Mathieu n, J. Bodle n & E. Loboa n

author keywords: Primary cilia; Finite element analysis; Mechanotransduction; Tensile strain; Ciliary membrane; Mechanobiology; Ciliary pocket; Adipose derived stem cells
MeSH headings : Adipose Tissue / cytology; Cells, Cultured; Cilia / physiology; Collagen; Finite Element Analysis; Humans; Mechanotransduction, Cellular; Models, Biological; Osteogenesis / physiology; Stem Cells / cytology; Stress, Mechanical
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Skin Tissue Engineering for the Infected Wound Site: Biodegradable PLA Nanofibers and a Novel Approach for Silver Ion Release Evaluated in a 3D Coculture System of Keratinocytes and Staphylococcus aureus

TISSUE ENGINEERING PART C-METHODS, 20(10), 790–797.

By: M. Mohiti-Asli n, B. Pourdeyhimi n & E. Loboa n

MeSH headings : Biocompatible Materials / chemistry; Cell Proliferation / drug effects; Cell Survival / drug effects; Coculture Techniques; DNA / metabolism; Epidermal Cells; Humans; Ions; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / ultrastructure; Lactic Acid / chemistry; Nanofibers / chemistry; Nanofibers / ultrastructure; Polyesters; Polymers / chemistry; Porosity; Silver / analysis; Skin / pathology; Staphylococcus aureus / cytology; Staphylococcus aureus / drug effects; Staphylococcus aureus / growth & development; Tissue Engineering / methods; Tissue Scaffolds / chemistry; Wound Infection / microbiology; Wound Infection / pathology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2013 journal article

Alternating Current Electric Fields of Varying Frequencies: Effects on Proliferation and Differentiation of Porcine Neural Progenitor Cells

Cellular Reprogramming, 15(5), 405–412.

By: J. Lim n, S. McCullen n, J. Piedrahita n, E. Loboa n & N. Olby n

MeSH headings : Animals; Cell Differentiation; Cell Proliferation; Cells, Cultured; Electricity; Electrodes; Fluorescence; Glial Fibrillary Acidic Protein / metabolism; Neural Stem Cells / cytology; Swine; Swine, Miniature; Tubulin / metabolism
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2013 journal article

In vitro testicular toxicity models: Opportunities for advancement via biomedical engineering techniques

Altex-Alternatives to Animal Experimentation, 30(3), 353–377.

By: L. Saldutti, B. Beyer, W. Breslin, T. Brown, R. Chapin, S. Campion, B. Enright, E. Faustman ...

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Primary Cilia: The Chemical Antenna Regulating Human Adipose-Derived Stem Cell Osteogenesis

PLOS ONE, 8(5).

By: J. Bodle n, C. Rubenstein n, M. Phillips n, S. Bernacki n, J. Qi*, A. Banes n, E. Loboa n

MeSH headings : Adipose Tissue / cytology; Analysis of Variance; Cell Differentiation / physiology; Cilia / physiology; Cilia / ultrastructure; Gene Knockdown Techniques; Genetic Engineering / methods; Humans; Microscopy, Fluorescence; Multipotent Stem Cells / physiology; Osteogenesis / physiology; RNA Interference; RNA, Small Interfering / genetics; Real-Time Polymerase Chain Reaction; TRPP Cation Channels / genetics; TRPP Cation Channels / metabolism; Tumor Suppressor Proteins / genetics; Tumor Suppressor Proteins / metabolism
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Sensitization of Transforming Growth Factor-beta Signaling by Multiple Peptides Patterned on DNA Nanostructures

BIOMACROMOLECULES, 14(12), 4157–4160.

By: R. Pedersen*, E. Loboa n & T. LaBean n

MeSH headings : Animals; Biotin / chemistry; Cell Line; DNA / chemistry; Drug Carriers / chemistry; Drug Carriers / pharmacology; Genes, Reporter; Mice; Nanostructures / chemistry; Nanostructures / ultrastructure; Peptide Fragments / chemistry; Peptide Fragments / pharmacology; Receptors, Transforming Growth Factor beta / metabolism; Signal Transduction; Streptavidin / chemistry; Transforming Growth Factor beta / pharmacology; Transforming Growth Factor beta / physiology
Source: Web Of Science
Added: August 6, 2018

2013 journal article

The Effects of Cyclic Hydrostatic Pressure on Chondrogenesis and Viability of Human Adipose- and Bone Marrow-Derived Mesenchymal Stem Cells in Three-Dimensional Agarose Constructs

TISSUE ENGINEERING PART A, 19(1-2), 299–306.

By: J. Puetzer n, J. Williams n, A. Gillies n, S. Bernacki n & E. Loboa n

MeSH headings : Adipocytes / cytology; Adipocytes / physiology; Cell Differentiation; Cell Proliferation; Cell Survival; Cells, Cultured; Chondrogenesis / physiology; Equipment Design; Humans; Hydrostatic Pressure; Mechanotransduction, Cellular / physiology; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / physiology; Sepharose / chemistry; Tissue Scaffolds
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Cytoskeletal and Focal Adhesion Influences on Mesenchymal Stem Cell Shape, Mechanical Properties, and Differentiation Down Osteogenic, Adipogenic, and Chondrogenic Pathways

TISSUE ENGINEERING PART B-REVIEWS, 18(6), 436–444.

By: P. Mathieu n & E. Loboa*

MeSH headings : Adipogenesis / physiology; Animals; Cell Differentiation; Cell Shape; Chondrogenesis / physiology; Cytoskeleton; Focal Adhesions; Humans; Mechanotransduction, Cellular; Mesenchymal Stem Cells / cytology; Osteogenesis / physiology
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Release Profiles of Tricalcium Phosphate Nanoparticles from Poly(L-lactic acid) Electrospun Scaffolds with Single Component, Core-Sheath, or Porous Fiber Morphologies: Effects on hASC Viability and Osteogenic Differentiation

MACROMOLECULAR BIOSCIENCE, 12(7), 893–900.

By: M. Asli n, B. Pourdeyhimi n & E. Loboa n

author keywords: biomaterials; controlled release scaffolds; human adipose derived stem cells; nanoparticles; osteogenesis
MeSH headings : Adipose Tissue / cytology; Adipose Tissue / drug effects; Adult; Biocompatible Materials / chemical synthesis; Biocompatible Materials / pharmacology; Bone and Bones / cytology; Bone and Bones / physiology; Calcium Phosphates / chemistry; Cell Differentiation / drug effects; Cell Proliferation / drug effects; Cell Survival / drug effects; Cells, Cultured; Female; Humans; Kinetics; Lactic Acid / chemistry; Microscopy, Electron, Scanning; Nanoparticles / chemistry; Nanoparticles / ultrastructure; Polyesters; Polymers / chemistry; Porosity; Stem Cells / cytology; Stem Cells / drug effects; Surface Properties; Tissue Engineering; Tissue Scaffolds
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Silver nanoparticles do not influence stem cell differentiation but cause minimal toxicity

NANOMEDICINE, 7(8), 1197–1209.

By: M. Samberg n, E. Loboa n, S. Oldenburg* & N. Monteiro-Riviere n

author keywords: in vitro; nanoparticles; nanotechnology; nanotoxicology; scaffolds; silver; stem cells
MeSH headings : Adipose Tissue / cytology; Adult; Cell Differentiation / drug effects; Cell Survival / drug effects; Cells, Cultured; Female; Humans; Metal Nanoparticles / toxicity; Metal Nanoparticles / ultrastructure; Silver / toxicity; Stem Cells / cytology; Stem Cells / drug effects; Young Adult
Sources: Web Of Science, ORCID
Added: August 6, 2018

2011 journal article

Adipose-Derived Stem Cells in Functional Bone Tissue Engineering: Lessons from Bone Mechanobiology

TISSUE ENGINEERING PART B-REVIEWS, 17(3), 195–211.

By: J. Bodle n, A. Hanson n & E. Loboa n

MeSH headings : Adipose Tissue / cytology; Adipose Tissue / physiology; Adipose Tissue / transplantation; Animals; Humans; Mechanotransduction, Cellular / physiology; Osteogenesis / physiology; Stem Cell Transplantation / trends; Stem Cells / cytology; Stem Cells / physiology; Tissue Engineering / trends
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Collagen-PCL Sheath-Core Bicomponent Electrospun Scaffolds Increase Osteogenic Differentiation and Calcium Accretion of Human Adipose-Derived Stem Cells

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 22(13), 1695–1712.

By: C. Haslauer n, A. Moghe n, J. Osborne n, B. Gupta n & E. Loboa n

author keywords: Biomedical applications; tissue engineering; fibers; nanostructures; human adipose-derived stem cells; electrospinning
MeSH headings : Adipose Tissue / cytology; Adipose Tissue / metabolism; Bone and Bones; Calcium / metabolism; Cell Differentiation; Cell Proliferation; Collagen / chemistry; Humans; Microscopy, Electron, Scanning; Nanofibers / chemistry; Osteogenesis; Polyesters / chemistry; Polymers; Stem Cells / cytology; Stem Cells / metabolism; Tissue Engineering; Tissue Scaffolds
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Dietary Calcium Restriction Affects Mesenchymal Stem Cell Activity and Bone Development in Neonatal Pigs

JOURNAL OF NUTRITION, 141(3), 373–379.

By: A. Mahajan n, L. Alexander n, B. Seabolt n, D. Catrambone*, J. McClung*, J. Odle n, T. Pfeiler n, E. Loboa n, C. Stahl n

MeSH headings : 25-Hydroxyvitamin D3 1-alpha-Hydroxylase / genetics; 25-Hydroxyvitamin D3 1-alpha-Hydroxylase / metabolism; Animals; Animals, Newborn; Bone Density; Bone Development; Bone and Bones / chemistry; Calcitriol / blood; Calcium / blood; Calcium / deficiency; Calcium, Dietary / administration & dosage; Cell Differentiation; Cell Proliferation; Cells, Cultured; Female; Gene Expression Regulation; Male; Mechanical Phenomena; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; Nutritional Status; Parathyroid Hormone / blood; RNA, Messenger / metabolism; Receptors, Calcium-Sensing / genetics; Receptors, Calcium-Sensing / metabolism; Sus scrofa
Sources: Web Of Science, ORCID
Added: August 6, 2018

2011 journal article

Laser Ablation Imparts Controlled Micro-Scale Pores in Electrospun Scaffolds for Tissue Engineering Applications

Annals of Biomedical Engineering, 39(12), 3021–3030.

By: S. McCullen n, S. Gittard n, P. Miller n, B. Pourdeyhimi n, R. Narayan n & E. Loboa n

author keywords: Human adipose-derived stem cells; Laser ablation; Electrospun; Scaffold; Micro-machining
MeSH headings : Adipocytes; Cell Adhesion; Cell Survival; Cells, Cultured; Female; Humans; Lactic Acid / chemistry; Laser Therapy; Mesenchymal Stem Cells; Middle Aged; Polyesters; Polymers / chemistry; Tissue Engineering / methods; Tissue Scaffolds
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2011 journal article

Microarray Analysis of Human Adipose-Derived Stem Cells in Three-Dimensional Collagen Culture: Osteogenesis Inhibits Bone Morphogenic Protein and Wnt Signaling Pathways, and Cyclic Tensile Strain Causes Upregulation of Proinflammatory Cytokine Regulators and Angiogenic Factors

TISSUE ENGINEERING PART A, 17(21-22), 2615–2627.

By: A. Charoenpanich n, M. Wall n, C. Tucker*, D. Andrews*, D. Lalush n & E. Loboa n

MeSH headings : Adipose Tissue / cytology; Adult; Angiogenesis Inducing Agents / metabolism; Bone Morphogenetic Proteins / genetics; Bone Morphogenetic Proteins / metabolism; Cells, Cultured; Collagen / metabolism; Cytokines / genetics; Cytokines / metabolism; Humans; Insulin-Like Growth Factor I / genetics; Middle Aged; Oligonucleotide Array Sequence Analysis / methods; Osteogenesis / genetics; Osteogenesis / physiology; Platelet-Derived Growth Factor / genetics; Signal Transduction / genetics; Signal Transduction / physiology; Stem Cells / cytology; Stem Cells / metabolism; Wnt Signaling Pathway / genetics; Wnt Signaling Pathway / physiology
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Application of Low-Frequency Alternating Current Electric Fields Via Interdigitated Electrodes: Effects on Cellular Viability, Cytoplasmic Calcium, and Osteogenic Differentiation of Human Adipose-Derived Stem Cells

TISSUE ENGINEERING PART C-METHODS, 16(6), 1377–1386.

By: S. McCullen n, J. McQuilling n, R. Grossfeld n, J. Lubischer n, L. Clarke n & E. Loboa n

MeSH headings : Adipose Tissue / cytology; Adult Stem Cells / cytology; Adult Stem Cells / metabolism; Adult Stem Cells / physiology; Calcium / metabolism; Cell Differentiation / physiology; Cell Proliferation; Cell Survival / physiology; Cells, Cultured; Cytoplasm / metabolism; Electric Stimulation / methods; Electricity; Electrodes; Humans; Osteoblasts / metabolism; Osteoblasts / physiology; Osteogenesis / physiology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2010 journal article

Effect of Varied Ionic Calcium on Human Adipose-Derived Stem Cell Mineralization

TISSUE ENGINEERING PART A, 16(6), 1971–1981.

By: S. McCullen n, J. Zhan*, M. Onorato n, S. Bernacki n & E. Loboa n

MeSH headings : Adipocytes / cytology; Calcium / pharmacology; Cell Differentiation / drug effects; Cell Proliferation / drug effects; Humans; Osteogenesis / drug effects; Spectroscopy, Fourier Transform Infrared; Stem Cells / cytology; Stem Cells / drug effects; Stem Cells / metabolism; Tissue Engineering / methods; X-Ray Diffraction
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Fiber-reinforced scaffolds for tissue engineering and regenerative medicine: use of traditional textile substrates to nanofibrous arrays

JOURNAL OF MATERIALS CHEMISTRY, 20(40), 8776–8788.

By: S. McCullen n, C. Haslauer n & E. Loboa n

Source: Web Of Science
Added: August 6, 2018

2010 journal article

In Situ Monitoring of Adipogenesis with Human-Adipose-Derived Stem Cells Using Surface-Enhanced Raman Spectroscopy

APPLIED SPECTROSCOPY, 64(11), 1227–1233.

By: B. Moody n, C. Haslauer n, E. Kirk n, A. Kannan n, E. Loboa n & G. McCarty n

author keywords: Raman spectroscopy; Adipogenesis; Stem cells; Surface-enhanced Raman spectroscopy; SERS
MeSH headings : Adipogenesis / physiology; Adipose Tissue / cytology; Adipose Tissue / metabolism; Adult; Cells, Cultured; Endocytosis; Female; Gold Colloid / chemistry; Gold Colloid / pharmacokinetics; Humans; Metal Nanoparticles / chemistry; Microscopy, Electron, Transmission; Spectrum Analysis, Raman / methods; Stem Cells / cytology; Stem Cells / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018

2010 journal article

In situ collagen polymerization of layered cell-seeded electrospun scaffolds for bone tissue engineering applications

Tissue Engineering. Part C, Methods, 16(5), 1095–1105.

By: S. McCullen, P. Miller, S. Gittard, R. Gorga*, B. Pourdeyhimi*, R. Narayan, E. Loboa*

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2010 journal article

Musculoskeletal mechanobiology: Interpretation by external force and engineered substratum

JOURNAL OF BIOMECHANICS, 43(1), 119–127.

By: S. McCullen n, C. Haslauer n & E. Loboa n

author keywords: Mechanobiology; Musculoskeletal; External forces; Cell-substrate interactions
MeSH headings : Adenosine Triphosphate / metabolism; Animals; Biomechanical Phenomena; Cytoskeleton / physiology; Humans; Mechanotransduction, Cellular; Muscle, Skeletal / physiology; Nitric Oxide / metabolism; Stress, Mechanical; Tensile Strength
Source: Web Of Science
Added: August 6, 2018

2010 journal article

The Development and Validation of a LIPUS System With Preliminary Observations of Ultrasonic Effects on Human Adult Stem Cells

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 57(9), 1977–1984.

By: S. Marvel*, S. Okrasinski*, S. Bernacki*, E. Loboa* & P. Dayton*

MeSH headings : Adipose Tissue / cytology; Adult; Adult Stem Cells / cytology; Adult Stem Cells / diagnostic imaging; Bone Marrow Cells / cytology; Calcium / analysis; Calcium / metabolism; Cell Growth Processes / physiology; Cells, Cultured; DNA / chemistry; Humans; Reproducibility of Results; Ultrasonics / instrumentation; Ultrasonics / methods; Ultrasonography
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Composite Tissue Engineering on Polycaprolactone Nanofiber Scaffolds

Annals of Plastic Surgery, 62(5), 505–512.

By: C. Reed*, L. Han, A. Andrady*, M. Caballero, M. Jack, J. Collins, S. Saba, E. Loboa n, B. Cairns, J. van Aalst

author keywords: nanofiber scaffolds; nanotechnology; composite tissue engineering; keratinocytes; fibroblasts; osteoinduction; fat-derived stem cells; periosteum; periosteal cells
MeSH headings : Adult Stem Cells / cytology; Animals; Biocompatible Materials; Cell Survival; Female; Fibroblasts / cytology; Foreskin / cytology; Humans; Keratinocytes / cytology; Male; Mice; Mice, Inbred C57BL; Nanostructures; Osteogenesis; Periosteum / cytology; Periosteum / growth & development; Polyesters; Plastic Surgery Procedures / methods; Tissue Culture Techniques; Tissue Engineering / methods; Tissue Scaffolds
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2009 chapter

Development and application of naturally renewable scaffold materials for bone tissue engineering

In L. A. Lucia & O. J. Rojas (Eds.), Nanotechnology of renewable materials.

By: S. McCullen*, A. Hanson*, L. Lucia* & E. Loboa*

Ed(s): . L. A. Lucia & O. Rojas

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2009 journal article

Electrospun composite poly(L-lactic acid)/tricalcium phosphate scaffolds induce proliferation and osteogenic differentiation of human adipose-derived stem cells

BIOMEDICAL MATERIALS, 4(3).

By: S. McCullen n, Y. Zhu*, S. Bernacki n, R. Narayan n, B. Pourdeyhimi n, R. Gorga n, E. Loboa n

MeSH headings : Adipocytes / cytology; Adipocytes / physiology; Biocompatible Materials / chemistry; Calcium Phosphates / chemistry; Cell Culture Techniques / methods; Cell Differentiation; Cell Proliferation; Cells, Cultured; Electrochemistry / methods; Humans; Lactic Acid / chemistry; Materials Testing; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / physiology; Osteoblasts / cytology; Osteoblasts / physiology; Osteogenesis / physiology; Polyesters; Polymers / chemistry; Rotation; Tissue Engineering / methods
Sources: Web Of Science, ORCID
Added: August 6, 2018

2009 journal article

Expression of Proinflammatory Cytokines by Human Mesenchymal Stem Cells in Response to Cyclic Tensile Strain

JOURNAL OF CELLULAR PHYSIOLOGY, 219(1), 77–83.

By: R. Sumanasinghe n, T. Pfeiler n, N. Monteiro-Riviere n & E. Loboa n

MeSH headings : Animals; Bone Marrow Cells / cytology; Bone Marrow Cells / physiology; Cells, Cultured; Cytokines / metabolism; Humans; Interleukin-1beta / metabolism; Interleukin-6 / metabolism; Interleukin-8 / metabolism; Male; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; Stress, Mechanical; Stress, Physiological; Tensile Strength; Tumor Necrosis Factor-alpha / metabolism; Young Adult
Sources: Web Of Science, ORCID
Added: August 6, 2018

2009 journal article

Mesenchymal stem cell-seeded collagen matrices for bone repair: Effects of cyclic tensile strain, cell density, and media conditions on matrix contraction in vitro

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 88A(3), 778–786.

By: R. Sumanasinghe n, J. Osborne n & E. Loboa n

author keywords: bone tissue engineering; mechanical stimulation; osteogenic differentiation; collagen contraction; mesenchymal stem cells
MeSH headings : Adult; Bone and Bones / cytology; Cell Culture Techniques / methods; Cell Differentiation; Cell Survival; Collagen; Culture Media, Conditioned; Humans; Male; Mesenchymal Stem Cells / cytology; Tensile Strength
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Osteogenic Effects of Rest Inserted and Continuous Cyclic Tensile Strain on hASC Lines with Disparate Osteodifferentiation Capabilities

ANNALS OF BIOMEDICAL ENGINEERING, 37(5), 955–965.

By: A. Hanson n, S. Marvel n, S. Bernacki n, A. Banes n, J. Aalst* & E. Loboa n

author keywords: Adipose derived stem cells; Mesenchymal stem cells; Osteogenesis; Mechanical effects on cells and tissues; Tissue engineering
MeSH headings : Adipose Tissue / cytology; Adult Stem Cells; Calcium / metabolism; Cell Differentiation; Cell Proliferation; Cells, Cultured; Humans; Mesenchymal Stem Cells; Models, Biological; Osteogenesis / physiology; Stress, Mechanical; Tensile Strength; Tissue Engineering / methods
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Cellular Incorporation Into Electrospun Nanofibers

Annals of Plastic Surgery, 60(5), 577–583.

By: J. van Aalst, C. Reed, L. Han, T. Andrady, M. Hromadka, S. Bernacki*, K. Kolappa, J. Collins, E. Loboa*

author keywords: nanofibers; fibroblasts; adipose-derived adult stem cells; electrospinning; nanotechnology
MeSH headings : Cell Proliferation; Cell Survival; Fibroblasts / physiology; Humans; Nanostructures / chemistry; Polymers; Tissue Engineering; Tissue Scaffolds
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2008 journal article

Cyclic tensile strain increases interactions between human epidermal keratinocytes and quantum dot nanoparticles

TOXICOLOGY IN VITRO, 22(2), 491–497.

By: J. Rouse n, C. Haslauer n, E. Loboa n & N. Monteiro-Riviere n

author keywords: quantum dot nanoparticles; keratinocytes; skin; tensile strain; cellular uptake
MeSH headings : Borates / toxicity; Cell Membrane Permeability / drug effects; Cell Survival / drug effects; Cells, Cultured; Cytokines / analysis; Cytokines / biosynthesis; Epidermal Cells; Epidermis / drug effects; Ethidium; Fluoresceins; Fluorescent Dyes; Humans; Keratinocytes / drug effects; Keratinocytes / physiology; Microscopy, Fluorescence; Pharmaceutical Vehicles / chemistry; Polyethylene Glycols / chemistry; Quantum Dots; Tensile Strength
Sources: Web Of Science, ORCID
Added: August 6, 2018

2008 journal article

Finite element modeling of 3D human mesenchymal stem cell-seeded collagen matrices exposed to tensile strain

JOURNAL OF BIOMECHANICS, 41(10), 2289–2296.

By: T. Pfeiler n, R. Sumanasinghe n & E. Loboa n

author keywords: uniaxial tensile strain; HMSCs; collagen; bioreactor; finite element modeling
MeSH headings : Biomechanical Phenomena / methods; Bioreactors; Cell Lineage; Cells, Cultured; Collagen / chemistry; Cytoskeleton / metabolism; Finite Element Analysis; Humans; Mesenchymal Stem Cells / cytology; Models, Theoretical; Pressure; Stress, Mechanical; Tensile Strength; Tissue Engineering / methods
Source: Web Of Science
Added: August 6, 2018

2008 review

Isolation of human mesenchymal stem cells from bone and adipose tissue

[Review of ]. Stem cell culture, 86, 257–278.

By: S. Bernacki, M. Wall & E. Loboa

Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

Characterization of electrospun nanocomposite scaffolds and biocompatibility with adipose-derived human mesenchymal stem cells

International Journal of Nanomedicine, 2(2), 253–263.

Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

Differential effects on messenger ribonucleic acid expression by bone marrow-derived human mesenchymal stem cells seeded in agarose constructs due to ramped and steady applications of cyclic hydrostatic pressure

TISSUE ENGINEERING, 13(6), 1151–1158.

By: A. Finger n, C. Sargent n, K. Dulaney n, S. Bernacki n & E. Loboa n

MeSH headings : Adolescent; Adult; Biocompatible Materials / chemistry; Bone Marrow Cells / cytology; Bone Marrow Cells / drug effects; Bone Marrow Cells / metabolism; Cell Culture Techniques / methods; Cells, Cultured; Chondrocytes / cytology; Chondrocytes / drug effects; Chondrocytes / metabolism; Chondrogenesis / drug effects; Chondrogenesis / physiology; Cytoskeletal Proteins / genetics; Cytoskeletal Proteins / metabolism; Gene Expression Regulation, Developmental / drug effects; Gene Expression Regulation, Developmental / physiology; Humans; Male; Mechanotransduction, Cellular / drug effects; Mechanotransduction, Cellular / physiology; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / drug effects; Mesenchymal Stem Cells / metabolism; Pressure; RNA, Messenger / metabolism; Sepharose / chemistry; Tissue Engineering / methods; Transforming Growth Factor beta / administration & dosage
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Effects of oxygen plasma treatment on adipose-derived human mesenchymal stem cell adherence to poly(L-lactic acid) scaffolds

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 18(11), 1387–1400.

By: A. Hanson n, M. Wall n, B. Pourdeyhimi n & E. Loboa n

author keywords: hydrophilicity; non-woven PLLA scaffold; cell morphology; cell viability; melt-blown PLLA scaffold
MeSH headings : Adipocytes / cytology; Cell Adhesion / drug effects; Cell Survival; Cells, Cultured; Humans; Lactic Acid / chemistry; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / drug effects; Microscopy, Electron, Scanning; Oxygen / chemistry; Oxygen / pharmacology; Polyesters; Polymers / chemistry; Tissue Scaffolds / chemistry
Sources: Web Of Science, ORCID
Added: August 6, 2018

2007 journal article

Effects of serial passaging on the adipogenic and osteogenic differentiation potential of adipose-derived human mesenchymal stem cells

TISSUE ENGINEERING, 13(6), 1291–1298.

By: M. Wall n, S. Bernacki n & E. Loboa n

MeSH headings : Adipocytes / cytology; Adipocytes / physiology; Adipogenesis / physiology; Adult; Cell Culture Techniques / methods; Cell Differentiation; Cells, Cultured; Female; Humans; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / physiology; Middle Aged; Osteocytes / cytology; Osteocytes / physiology; Osteogenesis / physiology; Tissue Engineering / methods
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Genetic background influences fluoride's effects on osteoclastogenesis

BONE, 41(6), 1036–1044.

By: D. Yan*, A. Gurumurth*, M. Wright n, T. Pfeiler n, E. Loboa n & E. Everett*

author keywords: F; osteoclastogenesis; hematopoietic colony-forming cell (CFC) assays; bone resorption markers; inbred mouse strains
MeSH headings : Alkaline Phosphatase / metabolism; Animals; Biomarkers / blood; Bone Density; Bone and Bones / cytology; Bone and Bones / metabolism; Colony-Forming Units Assay; Female; Fluorides / metabolism; Fluorides / pharmacology; Mice; Osteoclasts / drug effects; Osteoclasts / metabolism; Osteogenesis / drug effects; Osteogenesis / genetics; Stress, Mechanical
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Human adipose-derived adult stem cells upregulate palladin during osteogenesis and in response to cyclic tensile strain

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 293(5), C1532–C1538.

By: M. Wall n, A. Rachlin, C. Otey* & E. Loboa*

author keywords: adipose-derived adult stem cells; mechanobiology; Eps8; actin cytoskeleton; mesenchymal stem cells
MeSH headings : Actins / metabolism; Adaptor Proteins, Signal Transducing; Adipose Tissue / cytology; Adipose Tissue / metabolism; Adult; Adult Stem Cells / metabolism; Cell Lineage / genetics; Cell Shape; Cells, Cultured; Cytoskeletal Proteins / genetics; Cytoskeletal Proteins / metabolism; Female; Humans; Intracellular Signaling Peptides and Proteins / metabolism; Mechanotransduction, Cellular / genetics; Middle Aged; Osteogenesis / genetics; Phosphoproteins / genetics; Phosphoproteins / metabolism; Protein Isoforms / metabolism; RNA Interference; RNA, Messenger / metabolism; RNA, Small Interfering / metabolism; Stress Fibers / metabolism; Stress, Mechanical; Up-Regulation
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Semiautomated finite element mesh generation methods for a long bone

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE, 85(3), 196–202.

By: T. Pfeiler n, D. Lalush n & E. Loboa n

author keywords: canine radius; CT to FEA; four-point bending; strain gage
MeSH headings : Animals; Bone and Bones / diagnostic imaging; Cadaver; Computer Simulation; Dogs; Finite Element Analysis; North Carolina; Tomography, X-Ray Computed
Source: Web Of Science
Added: August 6, 2018

2006 article

Osteogenic differentiation of human mesenchymal stem cells in collagen matrices: Effect of uniaxial cyclic tensile strain on bone morphogenetic protein (BMP-2) mRNA expression

Sumanasinghe, R. D., Bernacki, S. H., & Loboa, E. G. (2006, December). TISSUE ENGINEERING, Vol. 12, pp. 3459–3465.

By: R. Sumanasinghe n, S. Bernacki n & E. Loboa n

MeSH headings : Adult; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins / biosynthesis; Bone Morphogenetic Proteins / genetics; Bone and Bones / cytology; Bone and Bones / metabolism; Cell Differentiation / physiology; Cell Survival / physiology; Cells, Cultured; Collagen Type I; Gene Expression Regulation, Developmental / physiology; Humans; Male; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; RNA, Messenger / biosynthesis; Tensile Strength; Transforming Growth Factor beta / biosynthesis; Transforming Growth Factor beta / genetics
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Mechanobiology of mandibular distraction osteogenesis: finite element analyses with a rat model

JOURNAL OF ORTHOPAEDIC RESEARCH, 23(3), 663–670.

By: E. Loboa*, T. Fang*, D. Parker*, S. Warren*, K. Fong*, M. Longaker*, D. Carter*

author keywords: mechanobiology; mandibular distraction osteogenesis; finite element analysis; computed tomography; mesenchymal tissue differentiation
MeSH headings : Animals; Finite Element Analysis; Hydrostatic Pressure; Male; Mandible / physiology; Mandible / surgery; Osteogenesis, Distraction; Rats; Rats, Sprague-Dawley; Tensile Strength
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Mechanobiology of mandibular distraction osteogenesis: experimental analyses with a rat model

BONE, 34(2), 336–343.

By: E. Loboa*, T. Fang*, S. Warren*, D. Lindsey*, K. Fong*, M. Longaker*, D. Carter*

author keywords: mandibular distraction osteogenesis; mechanobiology; rat model; mechanical testing; mesenchymal tissue
MeSH headings : Animals; Biomechanical Phenomena; Male; Mandible / pathology; Mandible / surgery; Osteogenesis / physiology; Osteogenesis, Distraction / methods; Rats; Rats, Sprague-Dawley; Stress, Mechanical; Tensile Strength
Source: Web Of Science
Added: August 6, 2018